SIMILAR PATTERNS OF AMINO ACIDS FOR 3IV6_C_SAMC301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct5 PROTEIN (YEAST
HYPOTHETICAL
PROTEIN, SELENOMET)

(Saccharomyces
cerevisiae) 		PF01168
(Ala_racemase_N) 		5 ARG A 127
PRO A 136
SER A 116
ILE A 164
LEU A 177
 None
 1.21A 3iv6C-1ct5A:
undetectable		 3iv6C-1ct5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		5 PRO A 267
SER A 239
ASP A 248
ILE A 376
LEU A 286
 None
 1.26A 3iv6C-1e8tA:
undetectable		 3iv6C-1e8tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		5 GLY A 253
ASP A 274
ILE A 273
ARG A 262
LEU A 257
 None
 1.16A 3iv6C-1fp3A:
undetectable		 3iv6C-1fp3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		5 PHE A 151
GLY A 207
SER A 204
ILE A 244
ARG A 175
 None
 1.28A 3iv6C-1gq8A:
undetectable		 3iv6C-1gq8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy5 CALSEPRRP

(Calystegia
sepium) 		PF00445
(Ribonuclease_T2) 		5 PRO A  80
GLY A  39
THR A  41
ILE A 206
ARG A  33
 None
 1.18A 3iv6C-1jy5A:
undetectable		 3iv6C-1jy5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy5 CALSEPRRP

(Calystegia
sepium) 		PF00445
(Ribonuclease_T2) 		5 PRO A  80
GLY A  39
THR A  41
SER A 137
ILE A 206
 None
 1.20A 3iv6C-1jy5A:
undetectable		 3iv6C-1jy5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc0 BILIVERDIN REDUCTASE
A

(Rattus
norvegicus) 		PF01408
(GFO_IDH_MocA)
PF09166
(Biliv-reduc_cat) 		5 ARG A 150
GLY A 147
PHE A 232
SER A 236
LEU A 212
 None
 1.35A 3iv6C-1lc0A:
3.6		 3iv6C-1lc0A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuj ODORANT BINDING
PROTEIN ASP2

(Apis mellifera) 		PF01395
(PBP_GOBP) 		5 GLY A  63
ASP A 105
ILE A 109
ARG A  57
LEU A  61
 None
 1.33A 3iv6C-1tujA:
undetectable		 3iv6C-1tujA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Pyrobaculum
aerophilum) 		PF01791
(DeoC) 		5 ARG A 126
SER A 148
ILE A 137
ARG A  95
LEU A 133
 None
 1.37A 3iv6C-1vcvA:
undetectable		 3iv6C-1vcvA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		5 PRO A 373
GLY A 178
THR A 355
PHE A 218
ARG A 183
 None
None
PO4  A 500 (-4.1A)
None
None
 1.34A 3iv6C-1vlpA:
undetectable		 3iv6C-1vlpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 GLY B 324
THR B 364
SER B 282
ILE B 292
ARG B  34
 None
 1.31A 3iv6C-1wa5B:
undetectable		 3iv6C-1wa5B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyo MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF00307
(CH) 		5 PHE A  70
GLY A  48
PHE A 118
ILE A  98
LEU A  85
 None
 1.25A 3iv6C-1wyoA:
undetectable		 3iv6C-1wyoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		5 GLY A 362
THR A 489
SER A 371
ILE A 418
LEU A 334
 None
 0.84A 3iv6C-1xfuA:
undetectable		 3iv6C-1xfuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		5 GLY A  49
PHE A 302
SER A 303
ILE A 281
LEU A  48
 None
 1.10A 3iv6C-1yp4A:
undetectable		 3iv6C-1yp4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		5 PRO A   6
GLY A 297
SER A 301
ILE A 312
LEU A 330
 None
 1.11A 3iv6C-1ypxA:
undetectable		 3iv6C-1ypxA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ziq GAMMA CRYSTALLIN E

(Rattus
norvegicus) 		PF00030
(Crystall) 		5 ARG A1139
GLY A1164
ILE A1091
ARG A1167
LEU A1166
 None
 1.19A 3iv6C-1ziqA:
undetectable		 3iv6C-1ziqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB

(Thermococcus
litoralis) 		PF11495
(Regulator_TrmB) 		5 PHE X 216
GLY X 193
ASP X 150
ILE X 147
LEU X 191
 None
 1.20A 3iv6C-2f5tX:
2.6		 3iv6C-2f5tX:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB

(Thermococcus
litoralis) 		PF11495
(Regulator_TrmB) 		5 PHE X 216
SER X 127
ASP X 150
ILE X 147
LEU X 191
 None
 1.26A 3iv6C-2f5tX:
2.6		 3iv6C-2f5tX:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ARG A 255
GLY A 281
THR A 287
PHE A 353
ILE A 273
 None
 1.35A 3iv6C-2g3nA:
undetectable		 3iv6C-2g3nA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		5 PRO A  84
GLY A  39
ILE A  74
ARG A  46
LEU A  44
 None
 1.15A 3iv6C-2hi1A:
undetectable		 3iv6C-2hi1A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 PRO A 202
THR A 196
SER A 288
ILE A 266
LEU A 191
 GOL  A 505 ( 4.6A)
NDP  A 400 (-3.2A)
None
None
None
 1.23A 3iv6C-2hxvA:
undetectable		 3iv6C-2hxvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		5 PHE A 181
THR A 184
ILE A 159
ARG A 143
LEU A 145
 None
 1.30A 3iv6C-2jakA:
undetectable		 3iv6C-2jakA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jli YOP PROTEINS
TRANSLOCATION
PROTEIN

(Yersinia pestis) 		PF01312
(Bac_export_2) 		5 PRO A 264
SER A 257
ILE A 326
ARG A 314
LEU A 316
 None
 1.27A 3iv6C-2jliA:
undetectable		 3iv6C-2jliA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpu RBP1

(Hordeum vulgare) 		PF00076
(RRM_1) 		5 GLY A  24
THR A  20
PHE A  29
ARG A  78
LEU A  75
 None
 1.36A 3iv6C-2mpuA:
undetectable		 3iv6C-2mpuA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ncl BOLA-LIKE PROTEIN 3

(Homo sapiens) 		PF01722
(BolA) 		5 ARG A  76
THR A  77
PHE A  44
SER A  69
ILE A  65
 None
 1.37A 3iv6C-2nclA:
undetectable		 3iv6C-2nclA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgc UNCHARACTERIZED
PROTEIN

(uncultured
marine organism) 		no annotation 5 PHE A  61
PRO A 112
GLY A 166
ILE A 134
LEU A 149
 None
 1.35A 3iv6C-2pgcA:
undetectable		 3iv6C-2pgcA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pso STAR-RELATED LIPID
TRANSFER PROTEIN 13

(Homo sapiens) 		PF01852
(START) 		5 PRO A 963
SER A1031
ASP A1051
ILE A1069
LEU A1055
 None
 1.28A 3iv6C-2psoA:
undetectable		 3iv6C-2psoA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00149
(Metallophos) 		5 ARG A 207
GLY A 220
ILE A 241
ARG A 224
LEU A 210
 None
 1.25A 3iv6C-2qjcA:
undetectable		 3iv6C-2qjcA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  33
THR A  97
ASP A  65
ILE A  66
LEU A  51
 None
 1.37A 3iv6C-2v6bA:
5.2		 3iv6C-2v6bA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		5 PRO A  50
GLY A 111
ILE A  62
ARG A 276
LEU A 110
 None
 1.27A 3iv6C-2vg2A:
undetectable		 3iv6C-2vg2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 PRO D 204
GLY D 178
SER D 390
ILE D  46
LEU D 177
 None
None
None
PMR  C1414 ( 4.7A)
GOL  D1530 ( 4.6A)
 1.31A 3iv6C-2ynmD:
undetectable		 3iv6C-2ynmD:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ARG A  70
THR A  69
PHE A 130
ILE A 153
LEU A 116
 None
 1.18A 3iv6C-2z0mA:
3.0		 3iv6C-2z0mA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 THR A  69
PHE A 130
SER A  59
ILE A 153
LEU A 116
 None
 1.25A 3iv6C-2z0mA:
3.0		 3iv6C-2z0mA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		5 GLY A  98
THR A 104
PHE A 237
ARG A 101
LEU A  99
 None
 1.19A 3iv6C-2zq5A:
undetectable		 3iv6C-2zq5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0v SENSOR PROTEIN

(Thermotoga
maritima) 		PF00989
(PAS) 		5 GLY A 469
SER A 474
ILE A 514
ARG A 435
LEU A 430
 None
None
None
None
EOH  A 101 ( 4.4A)
 1.37A 3iv6C-3a0vA:
undetectable		 3iv6C-3a0vA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 195
ASP A 162
ILE A 163
ARG A 176
LEU A 177
 None
None
None
SO4  A2003 (-3.1A)
None
 1.35A 3iv6C-3aczA:
2.3		 3iv6C-3aczA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 PRO B 191
GLY B 165
SER B 374
ILE B  46
LEU B 164
 None
 1.30A 3iv6C-3aeqB:
3.1		 3iv6C-3aeqB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbh NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Staphylococcus
epidermidis) 		PF00881
(Nitroreductase) 		5 PHE A  23
THR A 160
ASP A  35
ILE A  38
LEU A  85
 None
 1.25A 3iv6C-3gbhA:
undetectable		 3iv6C-3gbhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF01194
(RNA_pol_N) 		5 PRO J  64
THR C  54
ASP C 121
ILE C 117
LEU C 148
 None
 1.36A 3iv6C-3h0gJ:
undetectable		 3iv6C-3h0gJ:
14.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 12 TRP A  11
PHE A  18
ARG A  27
PRO A  28
GLY A  50
THR A  53
PHE A  72
SER A  73
ASP A  95
ILE A  96
ARG A 115
LEU A 116
 SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
None
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.3A)
SAM  A 301 ( 4.7A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.5A)
None
SAM  A 301 (-4.2A)
 0.26A 3iv6C-3iv6A:
44.6		 3iv6C-3iv6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 5 TRP A 204
PHE A  18
ARG A  27
PRO A  28
ARG A 115
 None
SAM  A 301 (-3.7A)
None
SAM  A 301 ( 4.8A)
None
 1.21A 3iv6C-3iv6A:
44.6		 3iv6C-3iv6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 GLY A 401
PHE A 380
SER A 397
ILE A 359
LEU A 402
 None
 1.35A 3iv6C-3k28A:
undetectable		 3iv6C-3k28A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1g PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Corynebacterium
glutamicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 GLY A 285
THR A 289
ILE A 238
ARG A  77
LEU A  79
 None
 1.29A 3iv6C-3m1gA:
undetectable		 3iv6C-3m1gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A 512
PRO A  84
THR A  86
ILE A  50
LEU A  59
 FAY  A 600 (-3.6A)
None
FAY  A 600 (-4.4A)
None
None
 1.17A 3iv6C-3q9tA:
2.0		 3iv6C-3q9tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		5 PHE A 216
GLY A 193
ASP A 150
ILE A 147
LEU A 191
 None
None
ACT  A 402 (-4.0A)
None
None
 1.17A 3iv6C-3qphA:
undetectable		 3iv6C-3qphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		5 ARG A 340
GLY A 107
ASP A 323
ILE A 300
LEU A  61
 None
 1.28A 3iv6C-3t7vA:
undetectable		 3iv6C-3t7vA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 GLY A 309
THR A 350
SER A 267
ILE A 277
ARG A  27
 None
 1.34A 3iv6C-4b8jA:
undetectable		 3iv6C-4b8jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		5 ARG A   8
THR A  43
ASP A  56
ILE A  73
LEU A 114
 None
 1.36A 3iv6C-4dpyA:
undetectable		 3iv6C-4dpyA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 THR A 362
SER A 342
ASP A 470
ILE A 517
LEU A 367
 None
 1.31A 3iv6C-4fffA:
undetectable		 3iv6C-4fffA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		5 TRP A   7
PHE A  15
SER A   8
ILE A 165
LEU A  31
 None
 1.01A 3iv6C-4issA:
undetectable		 3iv6C-4issA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		6 TRP A  14
GLY A  59
PHE A  81
ASP A 105
ARG A 153
LEU A 124
 SAH  A 502 (-3.8A)
SAH  A 502 (-3.6A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
None
None
 0.90A 3iv6C-4krgA:
16.9		 3iv6C-4krgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 TRP A  14
GLY A  61
PHE A  81
ASP A 105
ARG A 153
 SAH  A 502 (-3.8A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
None
 1.24A 3iv6C-4krgA:
16.9		 3iv6C-4krgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1q L-LACTATE
DEHYDROGENASE

([Bacillus]
selenitireducens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 171
THR A 151
SER A 186
ILE A 190
LEU A 158
 None
 1.26A 3iv6C-4m1qA:
4.3		 3iv6C-4m1qA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdc PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Sinorhizobium
meliloti) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		5 ARG A 215
GLY A 185
ILE A 145
ARG A  14
LEU A 181
 None
 1.32A 3iv6C-4mdcA:
undetectable		 3iv6C-4mdcA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PRO A 236
GLY A 185
PHE A 199
ILE A 206
LEU A 220
 None
 1.17A 3iv6C-4mewA:
undetectable		 3iv6C-4mewA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjk CRISPR PROTEIN

(Archaeoglobus
fulgidus) 		PF09704
(Cas_Cas5d) 		5 PRO A  78
GLY A 114
THR A 116
SER A 110
ILE A  18
 None
 1.29A 3iv6C-4mjkA:
undetectable		 3iv6C-4mjkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  33
THR A  97
ASP A  65
ILE A  66
LEU A  51
 None
 1.36A 3iv6C-4nd4A:
4.8		 3iv6C-4nd4A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		5 ARG A  37
PRO A  36
THR A  58
ILE A  84
LEU A  98
 None
 1.36A 3iv6C-4nzjA:
undetectable		 3iv6C-4nzjA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		5 PHE A 163
GLY A  12
SER A  36
ASP A 118
ILE A 116
 None
FDA  A 501 (-3.1A)
FDA  A 501 (-3.1A)
None
None
 1.19A 3iv6C-4opuA:
2.5		 3iv6C-4opuA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		5 PHE A 280
ARG A 283
GLY A 342
ASP A 335
LEU A 344
 None
 1.34A 3iv6C-4p3zA:
undetectable		 3iv6C-4p3zA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE

(Lactobacillus
jensenii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 THR A 212
PHE A 221
ILE A 202
ARG A 235
LEU A 204
 None
 0.92A 3iv6C-4prkA:
5.1		 3iv6C-4prkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pts GLUTATHIONE
S-TRANSFERASE

(Gordonia
bronchialis) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 GLY A 274
THR A 278
ILE A 227
ARG A  66
LEU A  68
 None
 1.33A 3iv6C-4ptsA:
undetectable		 3iv6C-4ptsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP2
COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C;
Enterovirus C) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 PHE 3 208
GLY 2 120
SER 3 122
ILE 2 246
LEU 2 236
 None
 1.20A 3iv6C-4q4y3:
undetectable		 3iv6C-4q4y3:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 TRP A 323
GLY A 340
THR A 338
ILE A 212
ARG A 346
 None
None
None
LLP  A  34 ( 3.9A)
None
 1.27A 3iv6C-4qhrA:
undetectable		 3iv6C-4qhrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG

(Homo sapiens) 		PF00515
(TPR_1)
PF12895
(ANAPC3)
PF13181
(TPR_8) 		5 TRP A 149
ARG A 473
THR A 167
SER A 150
ILE A 158
 None
 1.33A 3iv6C-4rg6A:
undetectable		 3iv6C-4rg6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk2 ALDO/KETO REDUCTASE

(Polaromonas sp.
JS666) 		PF00248
(Aldo_ket_red) 		5 THR A  86
PHE A  18
ILE A  45
ARG A 116
LEU A  71
 None
 1.22A 3iv6C-4xk2A:
undetectable		 3iv6C-4xk2A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 GLY A  94
THR A 118
ASP A  49
ILE A  48
LEU A  98
 NAG  A 701 ( 3.7A)
NAG  A 701 (-4.4A)
None
None
None
 1.29A 3iv6C-4z61A:
undetectable		 3iv6C-4z61A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT
HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis;
Candidatus
Kuenenia
stuttgartiensis) 		no annotation
PF02239
(Cytochrom_D1) 		5 ARG B 336
PRO B 279
GLY A 593
ILE A 299
LEU B 283
 BET  B 403 (-4.3A)
None
None
None
None
 1.09A 3iv6C-5c2vB:
undetectable		 3iv6C-5c2vB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Brucella ovis) 		PF13420
(Acetyltransf_4) 		5 PHE A  52
PRO A 177
SER A  85
ARG A  79
LEU A  81
 None
 1.32A 3iv6C-5dwmA:
undetectable		 3iv6C-5dwmA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2c XAA-PRO DIPEPTIDASE

(Mycobacterium
tuberculosis) 		PF01321
(Creatinase_N) 		5 ARG A  31
SER A 125
ILE A  14
ARG A   6
LEU A  10
 None
 1.08A 3iv6C-5e2cA:
undetectable		 3iv6C-5e2cA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evm FUSION GLYCOPROTEIN
F0

(Nipah
henipavirus) 		PF00523
(Fusion_gly) 		5 PHE A 282
PRO A  52
GLY A 264
SER A 232
ILE A 266
 None
 1.36A 3iv6C-5evmA:
undetectable		 3iv6C-5evmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftf TPR DOMAIN PROTEIN

(Bacteroides sp.
3_1_23) 		PF05970
(PIF1) 		5 ARG A 175
PRO A 131
GLY A 429
THR A 176
ILE A 180
 None
 1.37A 3iv6C-5ftfA:
undetectable		 3iv6C-5ftfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6

(Homo sapiens) 		PF07571
(TAF6_C) 		5 ARG J 373
PRO J 369
THR J 371
ARG J 315
LEU J 317
 None
 1.36A 3iv6C-5furJ:
undetectable		 3iv6C-5furJ:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 PRO A 218
GLY A 355
PHE A 360
SER A 240
ASP A 361
 None
None
None
None
SGN  A1522 (-2.8A)
 1.36A 3iv6C-5g2vA:
undetectable		 3iv6C-5g2vA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai) 		no annotation 5 PHE A 236
GLY A  64
PHE A 232
SER A 233
ILE A  35
 None
 1.18A 3iv6C-5gmtA:
undetectable		 3iv6C-5gmtA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gru DIABODY PROTEIN
DIABODY PROTEIN

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		5 TRP L  48
GLY H 225
THR H 227
PHE L 103
ILE L 101
 TRP  L  48 ( 0.5A)
GLY  H 225 ( 0.0A)
THR  H 227 ( 0.8A)
PHE  L 103 ( 1.3A)
ILE  L 101 ( 0.7A)
 1.28A 3iv6C-5gruL:
undetectable		 3iv6C-5gruL:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 ARG A 218
SER A 267
ASP A 301
ILE A 304
LEU A 308
 None
 1.35A 3iv6C-5hs1A:
undetectable		 3iv6C-5hs1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 TRP A   7
PHE A  15
SER A   8
ILE A 165
LEU A  31
 None
 1.01A 3iv6C-5i8iA:
3.2		 3iv6C-5i8iA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 204
THR A 123
SER A 298
ILE A 233
LEU A 208
 None
 1.28A 3iv6C-5iq0A:
2.7		 3iv6C-5iq0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		5 ARG A 267
THR A 268
ASP A 322
ILE A 362
LEU A 365
 None
 1.30A 3iv6C-5jxmA:
undetectable		 3iv6C-5jxmA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		5 ARG C  20
PHE C 389
ILE C 297
ARG C 368
LEU C 383
 None
 1.32A 3iv6C-5k1cC:
undetectable		 3iv6C-5k1cC:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE B 388
PRO B 373
GLY B 767
PHE B 320
LEU B 766
 None
 1.34A 3iv6C-5kyuB:
undetectable		 3iv6C-5kyuB:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t77 PUTATIVE LIPID II
FLIPPASE MURJ

(Thermosipho
africanus) 		PF03023
(MVIN) 		5 PHE A 184
THR A 181
PHE A 109
ILE A 106
LEU A 125
 None
 1.37A 3iv6C-5t77A:
undetectable		 3iv6C-5t77A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 TRP A 279
PRO A 385
GLY A 308
ILE A 153
LEU A 312
 None
 1.19A 3iv6C-5tufA:
2.7		 3iv6C-5tufA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 TRP A 279
PRO A 383
GLY A 308
ILE A 153
LEU A 312
 None
 1.22A 3iv6C-5tulA:
undetectable		 3iv6C-5tulA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 5 GLY A  33
SER A 181
ILE A 231
ARG A 147
LEU A  32
 None
 1.35A 3iv6C-5txfA:
undetectable		 3iv6C-5txfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlq LOC100158544 PROTEIN

(Xenopus
tropicalis) 		PF03133
(TTL) 		5 PHE A 382
PRO A 448
PHE A 514
ILE A 475
LEU A 458
 None
 1.10A 3iv6C-5vlqA:
undetectable		 3iv6C-5vlqA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ARG A 243
THR A 186
ILE A 134
ARG A 183
LEU A 150
 None
 1.28A 3iv6C-5vpuA:
4.7		 3iv6C-5vpuA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE

(Brucella
melitensis) 		PF00551
(Formyl_trans_N) 		5 TRP A 213
PHE A 221
PRO A 232
SER A 214
LEU A 235
 None
 1.04A 3iv6C-5vysA:
4.4		 3iv6C-5vysA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 5 GLY A 213
THR A 157
SER A 282
ILE A 363
LEU A 287
 None
 1.27A 3iv6C-5wkaA:
undetectable		 3iv6C-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 6 TRP A  16
GLY A  61
PHE A  83
ASP A 107
ARG A 157
LEU A 128
 SAH  A 701 (-3.8A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.2A)
None
None
 0.85A 3iv6C-5wp4A:
17.7		 3iv6C-5wp4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 6 TRP A  16
GLY A  61
PHE A  83
ASP A 107
ARG A 157
LEU A 128
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.2A)
None
None
 0.87A 3iv6C-5wp5A:
17.7		 3iv6C-5wp5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zt3 WA352

(Oryza sativa) 		no annotation 5 ARG A  88
GLY A  92
THR A  89
ILE A  30
ARG A  98
 None
 1.16A 3iv6C-5zt3A:
undetectable		 3iv6C-5zt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE

(Yersinia pestis) 		no annotation 5 PHE C 191
THR C 154
SER C 149
ILE C  91
LEU C  19
 None
 1.33A 3iv6C-6c4mC:
3.2		 3iv6C-6c4mC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		5 PRO N  24
GLY J 142
SER N 102
ASP J 126
ILE J  95
 None
 1.28A 3iv6C-6cfwN:
undetectable		 3iv6C-6cfwN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cph TCR BETA CHAIN

(Homo sapiens) 		no annotation 5 PHE E  56
ARG E  80
PRO E  81
THR E  88
ASP E  73
 None
 1.34A 3iv6C-6cphE:
undetectable		 3iv6C-6cphE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cph TCR BETA CHAIN

(Homo sapiens) 		no annotation 5 PHE E  56
ARG E  80
PRO E  81
THR E  88
ASP E  74
 None
 1.22A 3iv6C-6cphE:
undetectable		 3iv6C-6cphE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 5 ARG A 262
GLY A  51
SER A 399
ILE A 247
LEU A  47
 None
 0.98A 3iv6C-6dk2A:
undetectable		 3iv6C-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 PRO A  83
GLY A  38
ILE A  73
ARG A  45
LEU A  43
 None
 1.08A 3iv6C-6e85A:
undetectable		 3iv6C-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 GLY A 525
SER A 528
ILE A 508
ARG A 550
LEU A 523
 None
 1.15A 3iv6C-6g9oA:
undetectable		 3iv6C-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8o ICE INHIBITOR

(Cowpox virus) 		PF00079
(Serpin) 		3 SER A 274
ASP A 276
ASP A 264
 None
 0.80A 3iv6C-1c8oA:
undetectable		 3iv6C-1c8oA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus) 		PF00581
(Rhodanese) 		3 SER A  76
ASP A  65
ASP A  82
 None
 0.73A 3iv6C-1dp2A:
undetectable		 3iv6C-1dp2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN

(Clostridium
botulinum;
Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF01742
(Peptidase_M27) 		3 SER B 294
ASP B 291
ASP A 123
 None
 0.82A 3iv6C-1e1hB:
undetectable		 3iv6C-1e1hB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0i INOSITOL
MONOPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF00459
(Inositol_P) 		3 SER A 241
ASP A 188
ASP A 246
 None
 0.92A 3iv6C-1g0iA:
undetectable		 3iv6C-1g0iA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g33 PARVALBUMIN ALPHA

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		3 SER A  65
ASP A  76
ASP A  61
 None
 0.67A 3iv6C-1g33A:
undetectable		 3iv6C-1g33A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhn CALNEXIN

(Canis lupus) 		PF00262
(Calreticulin) 		3 SER A  67
ASP A 454
ASP A 444
 None
 0.94A 3iv6C-1jhnA:
undetectable		 3iv6C-1jhnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no5 HYPOTHETICAL PROTEIN
HI0073

(Haemophilus
influenzae) 		PF01909
(NTP_transf_2) 		3 SER A  35
ASP A  48
ASP A   8
 ZN  A 501 ( 4.2A)
ZN  A 501 ( 2.6A)
None
 0.74A 3iv6C-1no5A:
undetectable		 3iv6C-1no5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii) 		PF00331
(Glyco_hydro_10) 		3 SER A 121
ASP A 123
ASP A 230
 None
 0.80A 3iv6C-1nq6A:
undetectable		 3iv6C-1nq6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		3 SER A 245
ASP A 312
ASP A 251
 None
 0.91A 3iv6C-1oywA:
2.8		 3iv6C-1oywA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		3 SER A 120
ASP A  93
ASP A  98
 None
 0.80A 3iv6C-1pxzA:
undetectable		 3iv6C-1pxzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		PF00561
(Abhydrolase_1) 		3 SER D 153
ASP D  21
ASP D 157
 None
 0.88A 3iv6C-1qgeD:
undetectable		 3iv6C-1qgeD:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxy METHIONYL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00557
(Peptidase_M24) 		3 SER A  95
ASP A  93
ASP A  59
 M2C  A3001 ( 3.8A)
CO  A1002 ( 1.8A)
None
 0.86A 3iv6C-1qxyA:
undetectable		 3iv6C-1qxyA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdn GLUTAMINE BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		3 SER A 193
ASP A  80
ASP A  63
 None
 0.75A 3iv6C-1wdnA:
undetectable		 3iv6C-1wdnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		3 SER A 294
ASP A 135
ASP A 298
 None
 0.69A 3iv6C-1xe4A:
undetectable		 3iv6C-1xe4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjm POLYNUCLEOTIDE
5'-HYDROXYL-KINASE

(Mus musculus) 		no annotation 3 SER A  86
ASP A  91
ASP A  56
 None
 0.77A 3iv6C-1yjmA:
undetectable		 3iv6C-1yjmA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zeq CATION EFFLUX SYSTEM
PROTEIN CUSF

(Escherichia
coli) 		PF11604
(CusF_Ec) 		3 SER X  60
ASP X  83
ASP X  66
 None
 0.72A 3iv6C-1zeqX:
undetectable		 3iv6C-1zeqX:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		3 SER A 418
ASP A 320
ASP A 422
 PIB  A3632 (-2.5A)
None
PIB  A3632 (-3.6A)
 0.92A 3iv6C-1zsqA:
undetectable		 3iv6C-1zsqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		3 SER A  37
ASP A  41
ASP A  70
 None
 0.86A 3iv6C-2a9vA:
2.2		 3iv6C-2a9vA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		3 SER A 778
ASP A 678
ASP A 781
 None
 0.95A 3iv6C-2b3xA:
undetectable		 3iv6C-2b3xA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 SER A 159
ASP A 164
ASP A 272
 None
 0.92A 3iv6C-2c5aA:
5.1		 3iv6C-2c5aA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 SER A 233
ASP A 238
ASP A 269
 None
None
MG  A 602 (-3.7A)
 0.93A 3iv6C-2f43A:
undetectable		 3iv6C-2f43A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		3 SER A  14
ASP A  18
ASP A 179
 None
 0.86A 3iv6C-2g5xA:
undetectable		 3iv6C-2g5xA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		3 SER A 348
ASP A 352
ASP A 405
 None
 0.94A 3iv6C-2h1nA:
undetectable		 3iv6C-2h1nA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mnu EDB

(Homo sapiens) 		PF00041
(fn3) 		3 SER A  21
ASP A  19
ASP A  16
 None
 0.72A 3iv6C-2mnuA:
undetectable		 3iv6C-2mnuA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7d PROTEIN DDI1 HOMOLOG
2

(Homo sapiens) 		PF00240
(ubiquitin) 		3 SER A 163
ASP A 124
ASP A 156
 None
 0.77A 3iv6C-2n7dA:
undetectable		 3iv6C-2n7dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 SER A 301
ASP A 253
ASP A 424
 None
TLA  A 528 (-4.1A)
None
 0.86A 3iv6C-2pyxA:
undetectable		 3iv6C-2pyxA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		3 SER A 276
ASP A 152
ASP A 294
 None
FAD  A 500 (-4.9A)
None
 0.86A 3iv6C-2qa1A:
2.9		 3iv6C-2qa1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		3 SER A 276
ASP A 152
ASP A 294
 None
FAD  A 500 (-4.8A)
None
 0.81A 3iv6C-2qa2A:
undetectable		 3iv6C-2qa2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcq BONE MORPHOGENETIC
PROTEIN 3

(Homo sapiens) 		PF00019
(TGF_beta) 		3 SER A  31
ASP A  33
ASP A  19
 None
 0.93A 3iv6C-2qcqA:
undetectable		 3iv6C-2qcqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 SER D 287
ASP D 239
ASP D 125
 None
 0.92A 3iv6C-2qe7D:
2.7		 3iv6C-2qe7D:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7l AGGLUTININ-LIKE ALS9
PROTEIN

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		3 SER A 124
ASP A 259
ASP A 130
 None
 0.83A 3iv6C-2y7lA:
undetectable		 3iv6C-2y7lA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yf0 MYOTUBULARIN-RELATED
PROTEIN 6

(Homo sapiens) 		PF06602
(Myotub-related) 		3 SER A 337
ASP A 238
ASP A 341
 SO4  A1506 (-4.3A)
None
SO4  A1506 (-4.3A)
 0.93A 3iv6C-2yf0A:
undetectable		 3iv6C-2yf0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 SER B 180
ASP B 177
ASP B 134
 None
 0.81A 3iv6C-3a79B:
undetectable		 3iv6C-3a79B:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00903
(Glyoxalase) 		3 SER A 252
ASP A 202
ASP A 207
 None
 0.65A 3iv6C-3b59A:
undetectable		 3iv6C-3b59A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bow CALPASTATIN

(Rattus
norvegicus) 		PF00748
(Calpain_inhib) 		3 SER C 657
ASP C 654
ASP C 661
 None
 0.85A 3iv6C-3bowC:
undetectable		 3iv6C-3bowC:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		3 SER A 250
ASP A  34
ASP A 254
 None
ZN  A 601 ( 4.6A)
None
 0.79A 3iv6C-3c9fA:
undetectable		 3iv6C-3c9fA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 3 SER A 166
ASP A 104
ASP A 173
 None
 0.84A 3iv6C-3cv3A:
3.4		 3iv6C-3cv3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		3 SER A  79
ASP A  59
ASP A  86
 None
EDO  A 622 (-4.6A)
None
 0.85A 3iv6C-3e2dA:
2.1		 3iv6C-3e2dA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e58 PUTATIVE
BETA-PHOSPHOGLUCOMUT
ASE

(Streptococcus
thermophilus) 		PF13419
(HAD_2) 		3 SER A 110
ASP A   8
ASP A 115
 SO4  A 301 ( 4.6A)
None
None
 0.90A 3iv6C-3e58A:
2.9		 3iv6C-3e58A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		3 SER A  11
ASP A  32
ASP A 265
 FAD  A 298 (-2.6A)
FAD  A 298 (-3.0A)
FAD  A 298 (-3.0A)
 0.74A 3iv6C-3fbsA:
undetectable		 3iv6C-3fbsA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		3 SER A 129
ASP A 174
ASP A 123
 None
 0.79A 3iv6C-3h6eA:
undetectable		 3iv6C-3h6eA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3g N-ACETYLTRANSFERASE

(Trypanosoma
brucei) 		PF00583
(Acetyltransf_1) 		3 SER A  19
ASP A  16
ASP A  91
 None
 0.93A 3iv6C-3i3gA:
undetectable		 3iv6C-3i3gA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 3 SER A  52
ASP A  71
ASP A 114
 SAM  A 301 (-2.6A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.7A)
 0.11A 3iv6C-3iv6A:
44.6		 3iv6C-3iv6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		3 SER A 179
ASP A 181
ASP A 156
 None
 0.77A 3iv6C-3kd8A:
undetectable		 3iv6C-3kd8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		3 SER A 270
ASP A 266
ASP A 214
 GOL  A 312 (-3.6A)
GOL  A 312 (-2.9A)
None
 0.64A 3iv6C-3m9uA:
undetectable		 3iv6C-3m9uA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 SER A 441
ASP A 483
ASP A 444
 None
 0.76A 3iv6C-3mcaA:
undetectable		 3iv6C-3mcaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkv PUTATIVE
AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 SER A 135
ASP A 170
ASP A 203
 None
 0.82A 3iv6C-3mkvA:
undetectable		 3iv6C-3mkvA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvp TETR/ACRR
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
mutans) 		PF00440
(TetR_N) 		3 SER A  95
ASP A  92
ASP A 100
 None
 0.88A 3iv6C-3mvpA:
undetectable		 3iv6C-3mvpA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 140
ASP A 149
ASP A 196
 None
None
MG  A 378 ( 4.2A)
 0.61A 3iv6C-3my9A:
undetectable		 3iv6C-3my9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		3 SER A1049
ASP A1061
ASP A1099
 None
 0.87A 3iv6C-3oaiA:
undetectable		 3iv6C-3oaiA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A   9
ASP A  32
ASP A 277
 FAD  A 500 (-2.5A)
FAD  A 500 (-2.9A)
FAD  A 500 (-3.0A)
 0.75A 3iv6C-3oc4A:
undetectable		 3iv6C-3oc4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oj1 DEHALOPEROXIDASE A

(Amphitrite
ornata) 		PF00042
(Globin) 		3 SER A 119
ASP A   5
ASP A  72
 SO4  A 195 ( 4.6A)
None
None
 0.94A 3iv6C-3oj1A:
undetectable		 3iv6C-3oj1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		3 SER A  97
ASP A  66
ASP A  49
 None
 0.91A 3iv6C-3r0sA:
undetectable		 3iv6C-3r0sA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk6 RUVB-LIKE 2

(Homo sapiens) 		PF06068
(TIP49) 		3 SER A 310
ASP A 349
ASP A 305
 None
 0.91A 3iv6C-3uk6A:
undetectable		 3iv6C-3uk6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		3 SER A 283
ASP A 274
ASP A 258
 None
 0.87A 3iv6C-3vmnA:
undetectable		 3iv6C-3vmnA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 SER A 217
ASP A 164
ASP A 168
 None
 0.90A 3iv6C-3w5nA:
undetectable		 3iv6C-3w5nA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		3 SER A 486
ASP A 421
ASP A 491
 None
 0.52A 3iv6C-3zdpA:
undetectable		 3iv6C-3zdpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyp CIP1

(Trichoderma
reesei) 		no annotation 3 SER A   8
ASP A   5
ASP A  11
 None
 0.76A 3iv6C-3zypA:
undetectable		 3iv6C-3zypA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdg NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 SER C  75
ASP C  95
ASP C 122
 None
 0.93A 3iv6C-4cdgC:
undetectable		 3iv6C-4cdgC:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4che POLYMERASE BASIC
PROTEIN 2

(Thogoto
thogotovirus) 		no annotation 3 SER A 332
ASP A 409
ASP A 377
 None
 0.88A 3iv6C-4cheA:
undetectable		 3iv6C-4cheA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI) 		3 SER C  55
ASP C  43
ASP C  50
 None
 0.87A 3iv6C-4d10C:
undetectable		 3iv6C-4d10C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER H 493
ASP H 491
ASP H 496
 None
 0.93A 3iv6C-4fxgH:
undetectable		 3iv6C-4fxgH:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Paraburkholderia
phymatum) 		PF04166
(PdxA) 		3 SER A 327
ASP A 324
ASP A 310
 None
 0.67A 3iv6C-4jqpA:
2.4		 3iv6C-4jqpA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8t UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF01843
(DIL) 		3 SER A1599
ASP A1677
ASP A1596
 None
 0.71A 3iv6C-4l8tA:
undetectable		 3iv6C-4l8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leb AGGLUTININ-LIKE
PROTEIN 3

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		3 SER A 124
ASP A 260
ASP A 130
 None
 0.85A 3iv6C-4lebA:
undetectable		 3iv6C-4lebA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nte DEPH

(Chromobacterium
violaceum) 		PF07992
(Pyr_redox_2) 		3 SER A  14
ASP A  35
ASP A 268
 FAD  A 301 (-2.6A)
FAD  A 301 (-3.0A)
FAD  A 301 (-2.9A)
 0.73A 3iv6C-4nteA:
3.5		 3iv6C-4nteA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 SER A 462
ASP A 275
ASP A 456
 None
 0.87A 3iv6C-4uzsA:
undetectable		 3iv6C-4uzsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		3 SER A 176
ASP A 423
ASP A 209
 None
 0.87A 3iv6C-4wj3A:
undetectable		 3iv6C-4wj3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		3 SER A 184
ASP A 217
ASP A 117
 None
 0.76A 3iv6C-4wzzA:
2.6		 3iv6C-4wzzA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		3 SER A 545
ASP A 674
ASP A 548
 None
 0.84A 3iv6C-4xjxA:
undetectable		 3iv6C-4xjxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrp HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
cruzi) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		3 SER A 150
ASP A  88
ASP A 174
 None
None
HIS  A 501 (-2.9A)
 0.94A 3iv6C-4yrpA:
undetectable		 3iv6C-4yrpA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 SER A 661
ASP A 657
ASP A 492
 None
 0.37A 3iv6C-5a3fA:
undetectable		 3iv6C-5a3fA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 SER A 860
ASP A 813
ASP A 843
 None
 0.81A 3iv6C-5a55A:
undetectable		 3iv6C-5a55A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 SER A  38
ASP A  35
ASP A 191
 None
SF4  A 503 (-2.2A)
None
 0.93A 3iv6C-5aa5A:
undetectable		 3iv6C-5aa5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boi GERMINATION PROTEIN
YPEB

(Bacillus
megaterium) 		PF03413
(PepSY)
PF14620
(YPEB) 		3 SER A 359
ASP A 362
ASP A 270
 None
 0.92A 3iv6C-5boiA:
undetectable		 3iv6C-5boiA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bty LPG1496

(Legionella
pneumophila) 		no annotation 3 SER A 193
ASP A 189
ASP A 241
 None
 0.59A 3iv6C-5btyA:
undetectable		 3iv6C-5btyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvi INTERFERON
REGULATORY FACTOR 4

(Mus musculus) 		PF10401
(IRF-3) 		3 SER A 285
ASP A 283
ASP A 288
 CL  A 503 (-4.7A)
None
None
 0.94A 3iv6C-5bviA:
undetectable		 3iv6C-5bviA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chh ARAC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF12625
(Arabinose_bd)
PF12833
(HTH_18) 		3 SER A 110
ASP A 116
ASP A 113
 None
 0.83A 3iv6C-5chhA:
undetectable		 3iv6C-5chhA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds8 FAB HPU98 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER A  96
ASP A 101
ASP A  98
 None
 0.87A 3iv6C-5ds8A:
undetectable		 3iv6C-5ds8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guf CDP-ARCHAEOL
SYNTHASE

(Aeropyrum
pernix) 		no annotation 3 SER A 104
ASP A 100
ASP A  41
 CTP  A 201 (-2.3A)
CTP  A 201 ( 3.4A)
None
 0.85A 3iv6C-5gufA:
undetectable		 3iv6C-5gufA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 3 SER B 622
ASP B 630
ASP B 110
 None
 0.92A 3iv6C-5iz5B:
undetectable		 3iv6C-5iz5B:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1

(Homo sapiens;
Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set)
PF13895
(Ig_2) 		3 SER D  87
ASP D  89
ASP A 196
 None
 0.73A 3iv6C-5knmD:
undetectable		 3iv6C-5knmD:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena) 		no annotation 3 SER A 122
ASP A 124
ASP A 228
 None
 0.86A 3iv6C-5m0kA:
undetectable		 3iv6C-5m0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n48 FIBRONECTIN

(Homo sapiens) 		no annotation 3 SER B1282
ASP B1280
ASP B1277
 None
 0.92A 3iv6C-5n48B:
undetectable		 3iv6C-5n48B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 3 SER B 624
ASP B 626
ASP B 677
 None
 0.84A 3iv6C-5swiB:
undetectable		 3iv6C-5swiB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szr PROTEIN PCDHGB2

(Mus musculus) 		PF00028
(Cadherin) 		3 SER A 458
ASP A 480
ASP A 506
 None
None
CA  A 712 (-3.5A)
 0.88A 3iv6C-5szrA:
undetectable		 3iv6C-5szrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u64 VHH-28

(Camelus
dromedarius) 		PF07686
(V-set) 		3 SER B 101
ASP B  95
ASP B   1
 None
 0.88A 3iv6C-5u64B:
undetectable		 3iv6C-5u64B:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE

(Leishmania
donovani) 		PF00579
(tRNA-synt_1b) 		3 SER A 314
ASP A 311
ASP A 294
 None
 0.87A 3iv6C-5usfA:
1.4		 3iv6C-5usfA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 3 SER B2621
ASP B 756
ASP B 770
 None
 0.73A 3iv6C-5wfcB:
undetectable		 3iv6C-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whg PROTEIN VMS1

(Saccharomyces
cerevisiae) 		no annotation 3 SER A 318
ASP A 350
ASP A 323
 None
 0.90A 3iv6C-5whgA:
undetectable		 3iv6C-5whgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 3 SER A 300
ASP A 547
ASP A 123
 None
 0.82A 3iv6C-5x9wA:
undetectable		 3iv6C-5x9wA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1

(Zygosaccharomyces
rouxii) 		no annotation 3 SER A 280
ASP A 220
ASP A 302
 None
 0.80A 3iv6C-5yk7A:
undetectable		 3iv6C-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 3 SER A  94
ASP A 159
ASP A  91
 None
 0.93A 3iv6C-6aneA:
undetectable		 3iv6C-6aneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 3 SER A 394
ASP A 361
ASP A 399
 None
 0.76A 3iv6C-6aunA:
undetectable		 3iv6C-6aunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b20 GUANINE
NUCLEOTIDE-BINDING
PROTEIN
G(I)/G(S)/G(T)
SUBUNIT BETA-1

(Bos taurus) 		no annotation 3 SER A 265
ASP A 267
ASP A 247
 None
 0.90A 3iv6C-6b20A:
undetectable		 3iv6C-6b20A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 3 SER A 277
ASP A 137
ASP A 285
 None
 0.63A 3iv6C-6begA:
undetectable		 3iv6C-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 3 SER A 803
ASP A 798
ASP A 935
 None
 0.95A 3iv6C-6bf6A:
undetectable		 3iv6C-6bf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 SER A 194
ASP A 198
ASP A 225
 None
 0.86A 3iv6C-6eonA:
undetectable		 3iv6C-6eonA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epc PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
12

(Rattus
norvegicus) 		no annotation 3 SER P  21
ASP P  25
ASP P  59
 None
 0.81A 3iv6C-6epcP:
undetectable		 3iv6C-6epcP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		3 SER B 629
ASP B 625
ASP B 614
 None
 0.82A 3iv6C-6reqB:
undetectable		 3iv6C-6reqB:
19.50