SIMILAR PATTERNS OF AMINO ACIDS FOR 3IV6_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9o PROTEIN
(ALPHA-LACTALBUMIN)

(Homo sapiens) 		PF00062
(Lys) 		5 THR A   4
ASP A  84
ILE A  85
THR A  86
LEU A  11
 None
 1.29A 3iv6A-1b9oA:
undetectable		 3iv6A-1b9oA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		5 ASN A 267
PHE A  11
ILE A 232
THR A 229
LEU A 275
 None
 1.29A 3iv6A-1bhwA:
undetectable		 3iv6A-1bhwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		5 PRO A 475
THR A 462
SER A 446
ILE A 432
LEU A 465
 None
 1.27A 3iv6A-1c7jA:
2.4		 3iv6A-1c7jA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		5 ASN A 119
PHE A 149
PRO A 174
GLY A  83
ILE A 112
 None
None
None
SAH  A 699 (-3.2A)
SAH  A 699 ( 4.5A)
 1.08A 3iv6A-1dl5A:
7.8		 3iv6A-1dl5A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		5 PRO A 267
SER A 239
ASP A 248
ILE A 376
LEU A 286
 None
 1.25A 3iv6A-1e8tA:
undetectable		 3iv6A-1e8tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ASN A 198
PRO A 111
GLY A  77
ASP A 196
ILE A 165
 MG  A1001 ( 2.7A)
None
None
None
None
 1.28A 3iv6A-1itzA:
2.7		 3iv6A-1itzA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 GLY A2798
PHE A2796
ASP A2847
ILE A2848
THR A2849
 None
 1.19A 3iv6A-1js8A:
undetectable		 3iv6A-1js8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy5 CALSEPRRP

(Calystegia
sepium) 		PF00445
(Ribonuclease_T2) 		5 PRO A  80
GLY A  39
THR A  41
SER A 137
ILE A 206
 None
 1.19A 3iv6A-1jy5A:
undetectable		 3iv6A-1jy5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 GLY A 277
SER A 235
ILE A 268
THR A 264
LEU A 308
 None
 1.28A 3iv6A-1mqqA:
undetectable		 3iv6A-1mqqA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohz ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00404
(Dockerin_1) 		5 ASN B  40
GLY B   1
ASP B  38
THR B  46
LEU B  17
 CA  B1058 (-3.0A)
None
CA  B1058 (-2.9A)
None
None
 1.14A 3iv6A-1ohzB:
undetectable		 3iv6A-1ohzB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE

(Enterococcus
faecium) 		PF01427
(Peptidase_M15) 		5 PHE A 197
GLY A  42
ASP A 123
ILE A 122
LEU A  46
 None
None
ZN  A 203 (-2.5A)
None
None
 1.30A 3iv6A-1r44A:
undetectable		 3iv6A-1r44A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASN A 198
GLY A 173
SER A 188
ILE A 192
LEU A 160
 None
 1.17A 3iv6A-1y6jA:
3.5		 3iv6A-1y6jA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybm UNKNOWN PROTEIN
AT5G02240

(Arabidopsis
thaliana) 		PF13460
(NAD_binding_10) 		5 GLY A  11
SER A  39
ASP A  56
ILE A  57
THR A  58
 NAP  A 400 ( 3.8A)
NAP  A 400 ( 4.4A)
NAP  A 400 (-3.5A)
NAP  A 400 (-3.7A)
NAP  A 400 ( 4.5A)
 0.72A 3iv6A-1ybmA:
6.1		 3iv6A-1ybmA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C2

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B)
PF04896
(AmoC) 		5 TRP A 136
GLY A  95
THR C 162
PHE A  98
ILE A  99
 None
 1.31A 3iv6A-1yewA:
undetectable		 3iv6A-1yewA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		5 PRO A   6
GLY A 297
SER A 301
ILE A 312
LEU A 330
 None
 1.27A 3iv6A-1ypxA:
undetectable		 3iv6A-1ypxA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB

(Thermococcus
litoralis) 		PF11495
(Regulator_TrmB) 		5 PHE X 216
GLY X 193
ASP X 150
ILE X 147
LEU X 191
 None
 1.26A 3iv6A-2f5tX:
undetectable		 3iv6A-2f5tX:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB

(Thermococcus
litoralis) 		PF11495
(Regulator_TrmB) 		5 PHE X 216
GLY X 193
ILE X 147
THR X 146
LEU X 191
 None
 1.11A 3iv6A-2f5tX:
undetectable		 3iv6A-2f5tX:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 PHE A 173
GLY A 195
PHE A 148
THR A 262
LEU A 196
 None
 1.25A 3iv6A-2fj0A:
undetectable		 3iv6A-2fj0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens;
Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
no annotation 		5 PHE A  65
GLY I 138
SER I 143
ILE I 161
THR I 159
 None
 1.31A 3iv6A-2gk1A:
undetectable		 3iv6A-2gk1A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu1 ZINC PEPTIDASE

(Vibrio cholerae) 		PF01551
(Peptidase_M23)
PF04225
(OapA) 		5 PHE A 103
GLY A 105
PHE A 172
SER A 171
ILE A 107
 None
 1.23A 3iv6A-2gu1A:
undetectable		 3iv6A-2gu1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvo PUTATIVE LIPOPROTEIN

(Microbispora
sp. ATCC
PTA-5024) 		PF10709
(DUF2511) 		5 SER A  54
ASP A  61
ILE A  80
THR A  79
LEU A 137
 None
 1.27A 3iv6A-2mvoA:
undetectable		 3iv6A-2mvoA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nm0 PROBABLE
3-OXACYL-(ACYL-CARRI
ER-PROTEIN)
REDUCTASE

(Streptomyces
coelicolor) 		PF13561
(adh_short_C2) 		5 GLY A   9
SER A  35
ASP A  48
ILE A  49
THR A  50
 None
 0.89A 3iv6A-2nm0A:
5.8		 3iv6A-2nm0A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		5 ASN A 231
GLY A  81
THR A   4
ILE A 134
LEU A 125
 None
 1.14A 3iv6A-2nwqA:
5.5		 3iv6A-2nwqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pid TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		5 ASN A 259
GLY A 268
THR A 270
ASP A 265
THR A  57
 None
 1.23A 3iv6A-2pidA:
2.1		 3iv6A-2pidA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pso STAR-RELATED LIPID
TRANSFER PROTEIN 13

(Homo sapiens) 		PF01852
(START) 		5 PRO A 963
SER A1031
ASP A1051
ILE A1069
LEU A1055
 None
 1.26A 3iv6A-2psoA:
undetectable		 3iv6A-2psoA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 PRO A 162
GLY A 224
SER A 260
ILE A 242
LEU A 247
 None
 1.30A 3iv6A-2q1yA:
2.9		 3iv6A-2q1yA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		5 GLY A  32
THR A 185
SER A  56
ILE A  62
THR A  63
 None
ADP  A2001 (-3.3A)
None
None
None
 1.19A 3iv6A-2q2rA:
undetectable		 3iv6A-2q2rA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 PHE A  58
PRO A 132
ILE A  90
THR A  89
LEU A 102
 None
 1.07A 3iv6A-2rgwA:
undetectable		 3iv6A-2rgwA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhe BENCE-JONES PROTEIN
RHE (LIGHT CHAIN)

(Homo sapiens) 		PF07686
(V-set) 		5 GLY A 100
SER A  95
ILE A  29
THR A  70
LEU A   4
 None
 1.11A 3iv6A-2rheA:
undetectable		 3iv6A-2rheA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhq NTPASE P4

(Pseudomonas
phage phi12) 		PF11602
(NTPase_P4) 		5 ASN A 166
PHE A 158
SER A 190
ILE A 176
LEU A 214
 None
 1.18A 3iv6A-2vhqA:
undetectable		 3iv6A-2vhqA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 THR A  69
PHE A 130
SER A  59
ILE A 153
LEU A 116
 None
 1.20A 3iv6A-2z0mA:
3.6		 3iv6A-2z0mA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 ASN A  92
THR A 105
ASP A 338
ILE A 349
LEU A 381
 None
 1.30A 3iv6A-2z5xA:
2.9		 3iv6A-2z5xA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcx TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 ASN A 125
GLY A  36
ILE A  74
THR A  75
LEU A 114
 None
 1.15A 3iv6A-2zcxA:
undetectable		 3iv6A-2zcxA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 TRP A 151
PHE A 160
GLY A 132
ASP A 137
THR A  48
 None
 1.13A 3iv6A-3bitA:
undetectable		 3iv6A-3bitA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Cytophaga
hutchinsonii) 		PF03009
(GDPD) 		5 PHE A 268
PRO A   5
ASP A 219
THR A 221
LEU A 252
 None
None
EDO  A 275 ( 2.7A)
EDO  A 274 (-3.0A)
None
 1.22A 3iv6A-3ch0A:
undetectable		 3iv6A-3ch0A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		5 ASN A  54
THR A  24
ILE A  79
THR A  81
LEU A  94
 GTP  A 263 (-3.7A)
None
None
None
None
 1.11A 3iv6A-3cnnA:
undetectable		 3iv6A-3cnnA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE

(Salmonella
enterica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 PRO A 387
GLY A  13
THR A  15
ASP A  88
THR A  86
 None
 1.11A 3iv6A-3dqqA:
undetectable		 3iv6A-3dqqA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbh NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Staphylococcus
epidermidis) 		PF00881
(Nitroreductase) 		5 PHE A  23
THR A 160
ASP A  35
ILE A  38
LEU A  85
 None
 1.25A 3iv6A-3gbhA:
undetectable		 3iv6A-3gbhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		5 PHE A 254
GLY A 279
SER A 247
ILE A 285
THR A 123
 None
LLP  A 277 ( 4.4A)
LLP  A 277 ( 4.6A)
None
None
 1.24A 3iv6A-3hbxA:
undetectable		 3iv6A-3hbxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn0 NITRATE TRANSPORT
PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 ASN A 190
THR A 252
ASP A 188
ILE A 185
LEU A 173
 None
 1.27A 3iv6A-3hn0A:
undetectable		 3iv6A-3hn0A:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 12 ASN A   5
TRP A  11
PHE A  18
PRO A  28
GLY A  50
THR A  53
PHE A  72
SER A  73
ASP A  95
ILE A  96
THR A  97
LEU A 116
 SAM  A 301 ( 4.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.3A)
SAM  A 301 ( 4.7A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-4.2A)
 0.00A 3iv6A-3iv6A:
48.2		 3iv6A-3iv6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 5 GLY A  50
PHE A  70
ASP A  92
ILE A  91
THR A  90
 SAM  A 301 (-3.4A)
None
None
None
None
 1.18A 3iv6A-3iv6A:
48.2		 3iv6A-3iv6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 5 PRO A  28
GLY A  50
ASP A  92
ILE A  91
THR A  90
 SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
None
None
None
 1.19A 3iv6A-3iv6A:
48.2		 3iv6A-3iv6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 5 TRP A  11
PHE A  72
SER A  73
ILE A  49
LEU A 116
 SAM  A 301 (-3.7A)
SAM  A 301 (-3.3A)
SAM  A 301 ( 4.7A)
None
SAM  A 301 (-4.2A)
 1.28A 3iv6A-3iv6A:
48.2		 3iv6A-3iv6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		5 GLY A   9
SER A  37
ASP A  58
ILE A  59
THR A  60
 GOL  A 255 (-3.3A)
GOL  A 255 (-4.6A)
None
None
None
 1.05A 3iv6A-3kzvA:
3.5		 3iv6A-3kzvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		5 PRO A 178
GLY A  87
ASP A  58
ILE A  59
THR A  60
 None
GOL  A 255 ( 4.7A)
None
None
None
 1.28A 3iv6A-3kzvA:
3.5		 3iv6A-3kzvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 ASN A 395
GLY A 273
PHE A 391
SER A 388
THR A 251
 None
 1.09A 3iv6A-3m1cA:
undetectable		 3iv6A-3m1cA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpi GLUTARYL-COA
DEHYDROGENASE

(Desulfococcus
multivorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ASN A  35
PRO A 131
GLY A 213
THR A 158
SER A 210
 None
 1.19A 3iv6A-3mpiA:
undetectable		 3iv6A-3mpiA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nc3 CYTOCHROME P450 CYPX

(Bacillus
subtilis) 		PF00067
(p450) 		5 PHE A  15
SER A  37
ASP A  39
ILE A 303
THR A 302
 None
 1.18A 3iv6A-3nc3A:
undetectable		 3iv6A-3nc3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyw PUTATIVE
OXIDOREDUCTASE

(Bacteroides
thetaiotaomicron) 		PF00106
(adh_short) 		5 ASN A 221
PRO A  59
GLY A  24
ILE A 216
LEU A  25
 None
 1.26A 3iv6A-3nywA:
6.7		 3iv6A-3nywA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyw PUTATIVE
OXIDOREDUCTASE

(Bacteroides
thetaiotaomicron) 		PF00106
(adh_short) 		5 GLY A  12
SER A  38
ASP A  65
ILE A  66
THR A  67
 None
 0.79A 3iv6A-3nywA:
6.7		 3iv6A-3nywA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oag RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 GLY A  22
THR A  13
SER A   9
ILE A  24
THR A  98
 None
 1.09A 3iv6A-3oagA:
undetectable		 3iv6A-3oagA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A 512
PRO A  84
THR A  86
ILE A  50
LEU A  59
 FAY  A 600 (-3.6A)
None
FAY  A 600 (-4.4A)
None
None
 1.15A 3iv6A-3q9tA:
2.0		 3iv6A-3q9tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		5 PHE A 216
GLY A 193
ASP A 150
ILE A 147
LEU A 191
 None
None
ACT  A 402 (-4.0A)
None
None
 1.25A 3iv6A-3qphA:
undetectable		 3iv6A-3qphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		5 PHE A 216
GLY A 193
ILE A 147
THR A 146
LEU A 191
 None
 1.19A 3iv6A-3qphA:
undetectable		 3iv6A-3qphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rap PROTEIN (G PROTEIN
RAP2A)

(Homo sapiens) 		PF00071
(Ras) 		5 GLY R 115
THR R 145
PHE R  90
ILE R  93
LEU R 113
 None
 1.17A 3iv6A-3rapR:
undetectable		 3iv6A-3rapR:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ASN A 207
PRO A 117
GLY A  84
ASP A 205
ILE A 174
 MG  A1001 ( 2.6A)
None
None
None
None
 1.30A 3iv6A-3rimA:
2.5		 3iv6A-3rimA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 ASN A  95
TRP A  65
ASP A  96
THR A 482
LEU A 138
 None
 1.24A 3iv6A-3sghA:
undetectable		 3iv6A-3sghA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 PHE A 476
THR A 449
ASP A 504
ILE A 508
LEU A 540
 None
 1.21A 3iv6A-4d5gA:
2.7		 3iv6A-4d5gA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		6 GLY A 551
PHE A 706
SER A 707
ASP A 545
ILE A 549
LEU A 552
 None
 1.49A 3iv6A-4fm9A:
undetectable		 3iv6A-4fm9A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		5 ASN A 496
GLY A  29
SER A 291
ILE A 494
THR A 515
 None
 0.88A 3iv6A-4ia5A:
2.2		 3iv6A-4ia5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		5 TRP A   7
PHE A  15
SER A   8
ILE A 165
LEU A  31
 None
 1.09A 3iv6A-4issA:
undetectable		 3iv6A-4issA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 TRP A  14
GLY A  59
PHE A  81
ASP A 105
LEU A 124
 SAH  A 502 (-3.8A)
SAH  A 502 (-3.6A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
None
 0.85A 3iv6A-4krgA:
17.0		 3iv6A-4krgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llo POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Mus musculus) 		PF13426
(PAS_9) 		5 THR B  79
PHE B 109
ASP B 132
ILE B 133
THR B 134
 None
 1.29A 3iv6A-4lloB:
undetectable		 3iv6A-4lloB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1q L-LACTATE
DEHYDROGENASE

([Bacillus]
selenitireducens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 171
THR A 151
SER A 186
ILE A 190
LEU A 158
 None
 1.30A 3iv6A-4m1qA:
4.1		 3iv6A-4m1qA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjk CRISPR PROTEIN

(Archaeoglobus
fulgidus) 		PF09704
(Cas_Cas5d) 		5 PRO A  78
GLY A 114
THR A 116
SER A 110
ILE A  18
 None
 1.13A 3iv6A-4mjkA:
undetectable		 3iv6A-4mjkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF17205
(PSI_integrin) 		5 ASN B 518
GLY B 486
THR A 709
ASP B 515
ILE B 507
 None
 1.24A 3iv6A-4nenB:
undetectable		 3iv6A-4nenB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 353
THR A 355
ASP A  64
ILE A  58
THR A  60
 None
 1.02A 3iv6A-4nzsA:
undetectable		 3iv6A-4nzsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omb PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		5 ASN A  53
GLY A  47
THR A  80
ILE A  73
THR A  56
 None
 1.25A 3iv6A-4ombA:
undetectable		 3iv6A-4ombA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		5 PHE A 163
GLY A  12
SER A  36
ASP A 118
ILE A 116
 None
FDA  A 501 (-3.1A)
FDA  A 501 (-3.1A)
None
None
 1.22A 3iv6A-4opuA:
2.5		 3iv6A-4opuA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqj PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		5 ASN A  53
GLY A  47
THR A  80
ILE A  73
THR A  56
 None
 1.29A 3iv6A-4pqjA:
undetectable		 3iv6A-4pqjA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP2
COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C;
Enterovirus C) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 PHE 3 208
GLY 2 120
SER 3 122
ILE 2 246
LEU 2 236
 None
 1.25A 3iv6A-4q4y3:
undetectable		 3iv6A-4q4y3:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		5 PHE A 140
GLY A 136
ILE A 125
THR A 121
LEU A 156
 None
 0.90A 3iv6A-4s3kA:
undetectable		 3iv6A-4s3kA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u LINKER L3

(Glossoscolex
paulistus) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		5 GLY O 199
ASP O 112
ILE O 201
THR O 115
LEU O 185
 None
 1.11A 3iv6A-4u8uO:
undetectable		 3iv6A-4u8uO:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww3 RHODOPSIN

(Todarodes
pacificus) 		PF00001
(7tm_1) 		5 GLY A  88
THR A  93
PHE A  83
ASP A  80
ILE A 309
 None
 1.30A 3iv6A-4ww3A:
undetectable		 3iv6A-4ww3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frd CARBOXYLESTERASE
(EST-2)

(Archaeoglobus
fulgidus) 		PF12697
(Abhydrolase_6) 		5 ASN A  53
PHE A 175
GLY A  91
SER A  30
ILE A  49
 None
None
None
CL  A1258 (-2.9A)
None
 1.24A 3iv6A-5frdA:
2.8		 3iv6A-5frdA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 PRO A 218
GLY A 355
PHE A 360
SER A 240
ASP A 361
 None
None
None
None
SGN  A1522 (-2.8A)
 1.31A 3iv6A-5g2vA:
undetectable		 3iv6A-5g2vA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gru DIABODY PROTEIN
DIABODY PROTEIN

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		5 TRP L  48
GLY H 225
THR H 227
PHE L 103
ILE L 101
 TRP  L  48 ( 0.5A)
GLY  H 225 ( 0.0A)
THR  H 227 ( 0.8A)
PHE  L 103 ( 1.3A)
ILE  L 101 ( 0.7A)
 1.22A 3iv6A-5gruL:
undetectable		 3iv6A-5gruL:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 5 ASN B 105
TRP B 109
GLY B 350
THR B 273
LEU B 353
 None
 1.23A 3iv6A-5hdfB:
2.6		 3iv6A-5hdfB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 ASN A1968
TRP A1965
PRO A2031
GLY A1963
ILE A1940
 None
 1.30A 3iv6A-5i6gA:
undetectable		 3iv6A-5i6gA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 ASN A1968
TRP A1965
PRO A2031
GLY A1963
ILE A1940
 None
 1.28A 3iv6A-5i6hA:
undetectable		 3iv6A-5i6hA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 ASN A1968
TRP A1965
PRO A2031
GLY A1963
ILE A1940
 None
 1.26A 3iv6A-5i6iA:
undetectable		 3iv6A-5i6iA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 TRP A   7
PHE A  15
SER A   8
ILE A 165
LEU A  31
 None
 1.09A 3iv6A-5i8iA:
undetectable		 3iv6A-5i8iA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iao BIFUNCTIONAL PROTEIN
PYRR

(Mycobacterium
tuberculosis) 		PF00156
(Pribosyltran) 		5 GLY A  54
SER A 104
ASP A  84
ILE A  85
THR A  86
 None
 1.12A 3iv6A-5iaoA:
2.2		 3iv6A-5iaoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibz UNCHARACTERIZED
PROTEIN

(uncultured
organism) 		PF04199
(Cyclase) 		5 GLY A 298
ASP A 266
ILE A 220
THR A 222
LEU A 270
 None
 1.26A 3iv6A-5ibzA:
undetectable		 3iv6A-5ibzA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imw INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 ASN A 178
PHE A 272
PHE A 129
ILE A 128
LEU A 134
 None
 1.25A 3iv6A-5imwA:
undetectable		 3iv6A-5imwA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 204
THR A 123
SER A 298
ILE A 233
LEU A 208
 None
 1.28A 3iv6A-5iq0A:
undetectable		 3iv6A-5iq0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		5 GLY A 376
THR A 378
SER A 175
ILE A 335
LEU A 367
 None
 1.31A 3iv6A-5jkjA:
2.6		 3iv6A-5jkjA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE B 388
PRO B 373
GLY B 767
PHE B 320
LEU B 766
 None
 1.31A 3iv6A-5kyuB:
undetectable		 3iv6A-5kyuB:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA

(Klebsiella
pneumoniae;
Homo sapiens) 		PF01475
(FUR)
PF02198
(SAM_PNT) 		5 TRP A 119
PHE A 137
GLY A 141
ILE A 109
LEU A 145
 None
 1.11A 3iv6A-5l0pA:
undetectable		 3iv6A-5l0pA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 TRP A 279
PRO A 385
GLY A 308
ILE A 153
LEU A 312
 None
 1.26A 3iv6A-5tufA:
2.8		 3iv6A-5tufA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE
FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF10418
(DHODB_Fe-S_bind) 		5 PRO B 221
GLY B 226
ILE A 226
THR A 230
LEU B  90
 FAD  B 301 (-4.8A)
FES  B 302 (-3.5A)
None
None
None
 1.23A 3iv6A-5vj7B:
4.9		 3iv6A-5vj7B:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE

(Brucella
melitensis) 		PF00551
(Formyl_trans_N) 		5 TRP A 213
PHE A 221
PRO A 232
SER A 214
LEU A 235
 None
 1.04A 3iv6A-5vysA:
4.3		 3iv6A-5vysA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 5 GLY A 213
THR A 157
SER A 282
ILE A 363
LEU A 287
 None
 1.29A 3iv6A-5wkaA:
undetectable		 3iv6A-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 6 TRP A  16
GLY A  61
PHE A  83
ASP A 107
THR A 109
LEU A 128
 SAH  A 701 (-3.8A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.2A)
SAH  A 701 ( 4.6A)
None
 0.78A 3iv6A-5wp4A:
17.8		 3iv6A-5wp4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 6 TRP A  16
GLY A  61
PHE A  83
ASP A 107
THR A 109
LEU A 128
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.2A)
SAH  A 502 ( 4.8A)
None
 0.82A 3iv6A-5wp5A:
17.7		 3iv6A-5wp5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgw ISOASPARTYL
DIPEPTIDASE

(Colwellia
psychrerythraea) 		no annotation 5 ASN A 367
PRO A 261
GLY A 319
ILE A 372
THR A 373
 None
 1.26A 3iv6A-5xgwA:
undetectable		 3iv6A-5xgwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbt LYTIC MUREIN
TRANSGLYCOSYLASE

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 518
ASP A 548
ILE A 551
THR A 481
LEU A 519
 None
 1.27A 3iv6A-6fbtA:
undetectable		 3iv6A-6fbtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 5 GLY A 137
SER A 162
ASP A 187
THR A 189
LEU A 205
 SAH  A 501 (-3.5A)
None
SAH  A 501 (-4.2A)
None
SAH  A 501 (-4.3A)
 0.62A 3iv6A-6gkvA:
14.1		 3iv6A-6gkvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 5 SER A 162
ASP A 187
ILE A 188
THR A 189
LEU A 205
 None
SAH  A 501 (-4.2A)
SAH  A 501 (-3.9A)
None
SAH  A 501 (-4.3A)
 0.75A 3iv6A-6gkvA:
14.1		 3iv6A-6gkvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8o ICE INHIBITOR

(Cowpox virus) 		PF00079
(Serpin) 		3 SER A 274
ASP A 276
ASP A 264
 None
 0.82A 3iv6A-1c8oA:
undetectable		 3iv6A-1c8oA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		3 SER A 182
ASP A   8
ASP A 127
 None
 0.80A 3iv6A-1ct9A:
2.4		 3iv6A-1ct9A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus) 		PF00581
(Rhodanese) 		3 SER A  76
ASP A  65
ASP A  82
 None
 0.78A 3iv6A-1dp2A:
undetectable		 3iv6A-1dp2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN

(Clostridium
botulinum;
Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF01742
(Peptidase_M27) 		3 SER B 294
ASP B 291
ASP A 123
 None
 0.82A 3iv6A-1e1hB:
undetectable		 3iv6A-1e1hB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g33 PARVALBUMIN ALPHA

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		3 SER A  65
ASP A  76
ASP A  61
 None
 0.63A 3iv6A-1g33A:
undetectable		 3iv6A-1g33A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 SER A  96
ASP A  75
ASP A  67
 None
 0.89A 3iv6A-1khoA:
undetectable		 3iv6A-1khoA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		3 SER A 199
ASP A 169
ASP A 251
 None
 0.81A 3iv6A-1nhcA:
undetectable		 3iv6A-1nhcA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no5 HYPOTHETICAL PROTEIN
HI0073

(Haemophilus
influenzae) 		PF01909
(NTP_transf_2) 		3 SER A  35
ASP A  48
ASP A   8
 ZN  A 501 ( 4.2A)
ZN  A 501 ( 2.6A)
None
 0.70A 3iv6A-1no5A:
undetectable		 3iv6A-1no5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii) 		PF00331
(Glyco_hydro_10) 		3 SER A 121
ASP A 123
ASP A 230
 None
 0.80A 3iv6A-1nq6A:
0.7		 3iv6A-1nq6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		3 SER A 386
ASP A 390
ASP A 251
 None
 0.85A 3iv6A-1obhA:
undetectable		 3iv6A-1obhA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		3 SER A 245
ASP A 312
ASP A 251
 None
 0.88A 3iv6A-1oywA:
3.0		 3iv6A-1oywA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		3 SER A 120
ASP A  93
ASP A  98
 None
 0.79A 3iv6A-1pxzA:
undetectable		 3iv6A-1pxzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdn GLUTAMINE BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		3 SER A 193
ASP A  80
ASP A  63
 None
 0.76A 3iv6A-1wdnA:
undetectable		 3iv6A-1wdnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		3 SER A 294
ASP A 135
ASP A 298
 None
 0.69A 3iv6A-1xe4A:
undetectable		 3iv6A-1xe4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjm POLYNUCLEOTIDE
5'-HYDROXYL-KINASE

(Mus musculus) 		no annotation 3 SER A  86
ASP A  91
ASP A  56
 None
 0.78A 3iv6A-1yjmA:
undetectable		 3iv6A-1yjmA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zeq CATION EFFLUX SYSTEM
PROTEIN CUSF

(Escherichia
coli) 		PF11604
(CusF_Ec) 		3 SER X  60
ASP X  83
ASP X  66
 None
 0.77A 3iv6A-1zeqX:
undetectable		 3iv6A-1zeqX:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		3 SER A 418
ASP A 320
ASP A 422
 PIB  A3632 (-2.5A)
None
PIB  A3632 (-3.6A)
 0.88A 3iv6A-1zsqA:
undetectable		 3iv6A-1zsqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		3 SER A  37
ASP A  41
ASP A  70
 None
 0.86A 3iv6A-2a9vA:
2.3		 3iv6A-2a9vA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		3 SER A  14
ASP A  18
ASP A 179
 None
 0.83A 3iv6A-2g5xA:
undetectable		 3iv6A-2g5xA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inr DNA TOPOISOMERASE 4
SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		3 SER A 334
ASP A  33
ASP A 348
 None
 0.87A 3iv6A-2inrA:
undetectable		 3iv6A-2inrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		3 SER G 299
ASP G 297
ASP G 250
 None
 0.83A 3iv6A-2iouG:
undetectable		 3iv6A-2iouG:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2miu FOUR AND A HALF LIM
DOMAINS PROTEIN 2

(Homo sapiens) 		PF00412
(LIM) 		3 SER A  55
ASP A  53
ASP A  77
 None
 0.75A 3iv6A-2miuA:
undetectable		 3iv6A-2miuA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mnu EDB

(Homo sapiens) 		PF00041
(fn3) 		3 SER A  21
ASP A  19
ASP A  16
 None
 0.69A 3iv6A-2mnuA:
undetectable		 3iv6A-2mnuA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7d PROTEIN DDI1 HOMOLOG
2

(Homo sapiens) 		PF00240
(ubiquitin) 		3 SER A 163
ASP A 124
ASP A 156
 None
 0.85A 3iv6A-2n7dA:
undetectable		 3iv6A-2n7dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF03009
(GDPD) 		3 SER A 172
ASP A 174
ASP A 210
 None
 0.88A 3iv6A-2p76A:
undetectable		 3iv6A-2p76A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE

(Aneurinibacillus
thermoaerophilus) 		PF05523
(FdtA) 		3 SER A  64
ASP A 103
ASP A  99
 None
 0.70A 3iv6A-2paeA:
undetectable		 3iv6A-2paeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 SER A 301
ASP A 253
ASP A 424
 None
TLA  A 528 (-4.1A)
None
 0.86A 3iv6A-2pyxA:
3.3		 3iv6A-2pyxA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		3 SER A 276
ASP A 152
ASP A 294
 None
FAD  A 500 (-4.9A)
None
 0.88A 3iv6A-2qa1A:
undetectable		 3iv6A-2qa1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		3 SER A 276
ASP A 152
ASP A 294
 None
FAD  A 500 (-4.8A)
None
 0.84A 3iv6A-2qa2A:
undetectable		 3iv6A-2qa2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		3 SER A 248
ASP A 215
ASP A 251
 None
ZN  A 400 (-3.3A)
None
 0.88A 3iv6A-2qw5A:
undetectable		 3iv6A-2qw5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT

(Bacillus phage
SPP1) 		PF17288
(Terminase_3C) 		3 SER A 300
ASP A 296
ASP A 306
 None
 0.90A 3iv6A-2wbnA:
undetectable		 3iv6A-2wbnA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7l AGGLUTININ-LIKE ALS9
PROTEIN

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		3 SER A 124
ASP A 259
ASP A 130
 None
 0.83A 3iv6A-2y7lA:
undetectable		 3iv6A-2y7lA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yf0 MYOTUBULARIN-RELATED
PROTEIN 6

(Homo sapiens) 		PF06602
(Myotub-related) 		3 SER A 337
ASP A 238
ASP A 341
 SO4  A1506 (-4.3A)
None
SO4  A1506 (-4.3A)
 0.89A 3iv6A-2yf0A:
undetectable		 3iv6A-2yf0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		3 SER A 184
ASP A 124
ASP A 187
 None
 0.73A 3iv6A-2yp1A:
undetectable		 3iv6A-2yp1A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 SER B 180
ASP B 177
ASP B 134
 None
 0.79A 3iv6A-3a79B:
undetectable		 3iv6A-3a79B:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00903
(Glyoxalase) 		3 SER A 252
ASP A 202
ASP A 207
 None
 0.65A 3iv6A-3b59A:
undetectable		 3iv6A-3b59A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bow CALPASTATIN

(Rattus
norvegicus) 		PF00748
(Calpain_inhib) 		3 SER C 657
ASP C 654
ASP C 661
 None
 0.86A 3iv6A-3bowC:
undetectable		 3iv6A-3bowC:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		3 SER A 250
ASP A  34
ASP A 254
 None
ZN  A 601 ( 4.6A)
None
 0.74A 3iv6A-3c9fA:
undetectable		 3iv6A-3c9fA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 3 SER A 166
ASP A 104
ASP A 173
 None
 0.84A 3iv6A-3cv3A:
3.4		 3iv6A-3cv3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		3 SER A  79
ASP A  59
ASP A  86
 None
EDO  A 622 (-4.6A)
None
 0.85A 3iv6A-3e2dA:
undetectable		 3iv6A-3e2dA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e58 PUTATIVE
BETA-PHOSPHOGLUCOMUT
ASE

(Streptococcus
thermophilus) 		PF13419
(HAD_2) 		3 SER A 110
ASP A   8
ASP A 115
 SO4  A 301 ( 4.6A)
None
None
 0.85A 3iv6A-3e58A:
2.9		 3iv6A-3e58A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoo METHYLISOCITRATE
LYASE

(Burkholderia
pseudomallei) 		PF13714
(PEP_mutase) 		3 SER A  65
ASP A  90
ASP A  73
 None
 0.80A 3iv6A-3eooA:
undetectable		 3iv6A-3eooA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		3 SER A  11
ASP A  32
ASP A 265
 FAD  A 298 (-2.6A)
FAD  A 298 (-3.0A)
FAD  A 298 (-3.0A)
 0.70A 3iv6A-3fbsA:
undetectable		 3iv6A-3fbsA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		3 SER A 129
ASP A 174
ASP A 123
 None
 0.81A 3iv6A-3h6eA:
undetectable		 3iv6A-3h6eA:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 3 SER A  52
ASP A  71
ASP A 114
 SAM  A 301 (-2.6A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.7A)
 0.00A 3iv6A-3iv6A:
48.2		 3iv6A-3iv6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j40 GP7

(Salmonella
virus Epsilon15) 		no annotation 3 SER A  50
ASP A  48
ASP A  84
 None
 0.90A 3iv6A-3j40A:
undetectable		 3iv6A-3j40A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		3 SER A 179
ASP A 181
ASP A 156
 None
 0.76A 3iv6A-3kd8A:
undetectable		 3iv6A-3kd8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		3 SER A  45
ASP A  43
ASP A  51
 None
 0.87A 3iv6A-3lrkA:
undetectable		 3iv6A-3lrkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		3 SER A 270
ASP A 266
ASP A 214
 GOL  A 312 (-3.6A)
GOL  A 312 (-2.9A)
None
 0.66A 3iv6A-3m9uA:
undetectable		 3iv6A-3m9uA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 SER A 441
ASP A 483
ASP A 444
 None
 0.74A 3iv6A-3mcaA:
undetectable		 3iv6A-3mcaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkv PUTATIVE
AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 SER A 135
ASP A 170
ASP A 203
 None
 0.84A 3iv6A-3mkvA:
undetectable		 3iv6A-3mkvA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 140
ASP A 149
ASP A 196
 None
None
MG  A 378 ( 4.2A)
 0.61A 3iv6A-3my9A:
undetectable		 3iv6A-3my9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		3 SER A1049
ASP A1061
ASP A1099
 None
 0.87A 3iv6A-3oaiA:
undetectable		 3iv6A-3oaiA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A   9
ASP A  32
ASP A 277
 FAD  A 500 (-2.5A)
FAD  A 500 (-2.9A)
FAD  A 500 (-3.0A)
 0.71A 3iv6A-3oc4A:
2.9		 3iv6A-3oc4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 SER A 452
ASP A 395
ASP A 448
 None
FMT  A 501 (-3.8A)
None
 0.80A 3iv6A-3peiA:
undetectable		 3iv6A-3peiA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk6 RUVB-LIKE 2

(Homo sapiens) 		PF06068
(TIP49) 		3 SER A 310
ASP A 349
ASP A 305
 None
 0.89A 3iv6A-3uk6A:
undetectable		 3iv6A-3uk6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		3 SER A 283
ASP A 274
ASP A 258
 None
 0.88A 3iv6A-3vmnA:
undetectable		 3iv6A-3vmnA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 SER A 217
ASP A 164
ASP A 168
 None
 0.88A 3iv6A-3w5nA:
undetectable		 3iv6A-3w5nA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		3 SER A 486
ASP A 421
ASP A 491
 None
 0.54A 3iv6A-3zdpA:
undetectable		 3iv6A-3zdpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		3 SER A  19
ASP A  21
ASP A  88
 None
 0.62A 3iv6A-3zgxA:
undetectable		 3iv6A-3zgxA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		3 SER A 260
ASP A 256
ASP A 247
 None
 0.78A 3iv6A-3zxsA:
1.7		 3iv6A-3zxsA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyp CIP1

(Trichoderma
reesei) 		no annotation 3 SER A   8
ASP A   5
ASP A  11
 None
 0.73A 3iv6A-3zypA:
undetectable		 3iv6A-3zypA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4che POLYMERASE BASIC
PROTEIN 2

(Thogoto
thogotovirus) 		no annotation 3 SER A 332
ASP A 409
ASP A 377
 None
 0.79A 3iv6A-4cheA:
undetectable		 3iv6A-4cheA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 SER X 226
ASP X 149
ASP X 228
 None
 0.85A 3iv6A-4crmX:
undetectable		 3iv6A-4crmX:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI) 		3 SER C  55
ASP C  43
ASP C  50
 None
 0.84A 3iv6A-4d10C:
undetectable		 3iv6A-4d10C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz6 NUCLEOSIDE
DIPHOSPHATE KINASE

(Borreliella
burgdorferi) 		PF00334
(NDK) 		3 SER A 115
ASP A  15
ASP A 113
 None
 0.89A 3iv6A-4dz6A:
undetectable		 3iv6A-4dz6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER H 493
ASP H 491
ASP H 496
 None
 0.87A 3iv6A-4fxgH:
undetectable		 3iv6A-4fxgH:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		3 SER A 236
ASP A 121
ASP A 104
 ACT  A 305 ( 4.6A)
None
EDO  A 308 (-4.0A)
 0.82A 3iv6A-4h5gA:
undetectable		 3iv6A-4h5gA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8a UREIDOGLYCOLATE
DEHYDROGENASE

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 SER A 249
ASP A 141
ASP A 254
 None
 0.78A 3iv6A-4h8aA:
undetectable		 3iv6A-4h8aA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 SER A 196
ASP A 193
ASP A 198
 None
 0.90A 3iv6A-4jklA:
2.4		 3iv6A-4jklA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Paraburkholderia
phymatum) 		PF04166
(PdxA) 		3 SER A 327
ASP A 324
ASP A 310
 None
 0.71A 3iv6A-4jqpA:
undetectable		 3iv6A-4jqpA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l01 TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 SER A 632
ASP A 630
ASP A 660
 None
 0.82A 3iv6A-4l01A:
undetectable		 3iv6A-4l01A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		3 SER A 165
ASP A 167
ASP A 201
 None
 0.89A 3iv6A-4l22A:
undetectable		 3iv6A-4l22A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8t UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF01843
(DIL) 		3 SER A1599
ASP A1677
ASP A1596
 None
 0.74A 3iv6A-4l8tA:
undetectable		 3iv6A-4l8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leb AGGLUTININ-LIKE
PROTEIN 3

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		3 SER A 124
ASP A 260
ASP A 130
 None
 0.85A 3iv6A-4lebA:
undetectable		 3iv6A-4lebA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkq GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		3 SER B 228
ASP B 231
ASP B 257
 None
 0.90A 3iv6A-4nkqB:
undetectable		 3iv6A-4nkqB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nte DEPH

(Chromobacterium
violaceum) 		PF07992
(Pyr_redox_2) 		3 SER A  14
ASP A  35
ASP A 268
 FAD  A 301 (-2.6A)
FAD  A 301 (-3.0A)
FAD  A 301 (-2.9A)
 0.70A 3iv6A-4nteA:
3.1		 3iv6A-4nteA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 SER A 652
ASP A 656
ASP A 322
 None
 0.83A 3iv6A-4o9xA:
undetectable		 3iv6A-4o9xA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		3 SER A 444
ASP A 415
ASP A 467
 None
 0.83A 3iv6A-4qfuA:
undetectable		 3iv6A-4qfuA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 SER A1316
ASP A1318
ASP A1391
 None
 0.81A 3iv6A-4r04A:
undetectable		 3iv6A-4r04A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		3 SER A  32
ASP A  10
ASP A  13
 None
None
NAG  A 501 (-3.9A)
 0.67A 3iv6A-4u7lA:
undetectable		 3iv6A-4u7lA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 SER A 462
ASP A 275
ASP A 456
 None
 0.82A 3iv6A-4uzsA:
undetectable		 3iv6A-4uzsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		3 SER A 176
ASP A 423
ASP A 209
 None
 0.89A 3iv6A-4wj3A:
undetectable		 3iv6A-4wj3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		3 SER A 184
ASP A 217
ASP A 117
 None
 0.72A 3iv6A-4wzzA:
undetectable		 3iv6A-4wzzA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		3 SER A 545
ASP A 674
ASP A 548
 None
 0.85A 3iv6A-4xjxA:
2.4		 3iv6A-4xjxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 SER A 661
ASP A 657
ASP A 492
 None
 0.38A 3iv6A-5a3fA:
undetectable		 3iv6A-5a3fA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 SER A 860
ASP A 813
ASP A 843
 None
 0.81A 3iv6A-5a55A:
undetectable		 3iv6A-5a55A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aho 5' EXONUCLEASE
APOLLO

(Homo sapiens) 		PF07522
(DRMBL) 		3 SER A 103
ASP A  96
ASP A 120
 None
EDO  A1316 (-3.8A)
ZN  A1320 (-2.5A)
 0.80A 3iv6A-5ahoA:
undetectable		 3iv6A-5ahoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bty LPG1496

(Legionella
pneumophila) 		no annotation 3 SER A 193
ASP A 189
ASP A 241
 None
 0.65A 3iv6A-5btyA:
undetectable		 3iv6A-5btyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chh ARAC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF12625
(Arabinose_bd)
PF12833
(HTH_18) 		3 SER A 110
ASP A 116
ASP A 113
 None
 0.87A 3iv6A-5chhA:
undetectable		 3iv6A-5chhA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds8 FAB HPU98 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER A  96
ASP A 101
ASP A  98
 None
 0.89A 3iv6A-5ds8A:
undetectable		 3iv6A-5ds8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guf CDP-ARCHAEOL
SYNTHASE

(Aeropyrum
pernix) 		no annotation 3 SER A 104
ASP A 100
ASP A  41
 CTP  A 201 (-2.3A)
CTP  A 201 ( 3.4A)
None
 0.85A 3iv6A-5gufA:
undetectable		 3iv6A-5gufA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 3 SER B 622
ASP B 630
ASP B 110
 None
 0.88A 3iv6A-5iz5B:
undetectable		 3iv6A-5iz5B:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5j DESMOCOLLIN-2,DESMOG
LEIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		3 SER A 146
ASP A 165
ASP A 192
 None
None
CA  A 624 (-3.6A)
 0.85A 3iv6A-5j5jA:
undetectable		 3iv6A-5j5jA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		3 SER A 431
ASP A 234
ASP A 250
 None
 0.84A 3iv6A-5jxlA:
undetectable		 3iv6A-5jxlA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1

(Homo sapiens;
Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set)
PF13895
(Ig_2) 		3 SER D  87
ASP D  89
ASP A 196
 None
 0.79A 3iv6A-5knmD:
undetectable		 3iv6A-5knmD:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1

(Mus musculus) 		PF01825
(GPS) 		3 SER A 294
ASP A 292
ASP A 231
 None
 0.82A 3iv6A-5kvmA:
undetectable		 3iv6A-5kvmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 3 SER B 286
ASP B 282
ASP B 561
 None
 0.82A 3iv6A-5ltmB:
undetectable		 3iv6A-5ltmB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena) 		no annotation 3 SER A 122
ASP A 124
ASP A 228
 None
 0.84A 3iv6A-5m0kA:
undetectable		 3iv6A-5m0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		3 SER B 152
ASP B 185
ASP B 154
 None
None
SEP  B 162 ( 4.0A)
 0.87A 3iv6A-5mrwB:
undetectable		 3iv6A-5mrwB:
19.97