SIMILAR PATTERNS OF AMINO ACIDS FOR 3IT4_C_BEZC503_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		4 ARG A 177
GLN A 184
LEU A  58
HIS A 181
 None
None
None
MN3  A 268 ( 3.2A)
 1.28A 3it4C-1o9iA:
0.0		 3it4C-1o9iA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c37 PEPTIDASE, M48
FAMILY

(Geobacter
sulfurreducens) 		PF01435
(Peptidase_M48) 		4 ARG A 118
GLN A 164
LEU A 168
HIS A 115
 None
 1.49A 3it4C-3c37A:
0.6		 3it4C-3c37A:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		4 ARG A   9
GLN A  14
LEU A 154
HIS A 177
 None
 0.37A 3it4C-3it4A:
38.0		 3it4C-3it4A:
100.00