SIMILAR PATTERNS OF AMINO ACIDS FOR 3ILU_H_HFZH800_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fgg GLUCURONYLTRANSFERAS
E I

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 PRO A 250
SER A 246
LEU A 285
SER A 286
 None
 1.46A 3iluH-1fggA:
undetectable		 3iluH-1fggA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 PRO A 197
SER A 200
LEU A1017
SER A 219
 None
 0.95A 3iluH-1hwwA:
undetectable		 3iluH-1hwwA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		4 PRO A 370
SER A 386
LEU A 424
SER A 423
 None
 1.48A 3iluH-1hzvA:
undetectable		 3iluH-1hzvA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iz6 INITIATION FACTOR 5A

(Pyrococcus
horikoshii) 		PF01287
(eIF-5a)
PF08207
(EFP_N) 		4 LYS A  60
PRO A  61
SER A  40
SER A  10
 None
 1.15A 3iluH-1iz6A:
0.0		 3iluH-1iz6A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 PRO A1296
SER A1278
LEU A1319
SER A1318
 None
 1.19A 3iluH-1jl5A:
0.0		 3iluH-1jl5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm7 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN

(Homo sapiens) 		PF00097
(zf-C3HC4) 		4 LYS A  45
SER A  80
LEU A  73
SER A  36
 None
 1.37A 3iluH-1jm7A:
undetectable		 3iluH-1jm7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PRO A 169
SER A 166
LEU A 173
SER A 172
 None
 1.41A 3iluH-1k4qA:
0.0		 3iluH-1k4qA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwi PROTEGRIN-3
PRECURSOR

(Sus scrofa) 		PF00666
(Cathelicidins) 		4 LYS A  74
PRO A  75
SER A  77
LEU A 113
 None
 1.29A 3iluH-1kwiA:
0.0		 3iluH-1kwiA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 LYS A 839
SER A 644
LEU A 824
SER A 826
 None
 1.29A 3iluH-1n7rA:
undetectable		 3iluH-1n7rA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		4 PRO A 727
SER A 623
LEU A 630
SER A 563
 None
 1.42A 3iluH-1nphA:
undetectable		 3iluH-1nphA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 LYS A 505
SER A 541
LEU A 507
SER A 481
 None
 1.24A 3iluH-1nugA:
undetectable		 3iluH-1nugA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanopyrus
kandleri) 		PF02289
(MCH) 		4 PRO A 111
SER A 109
LEU A  60
SER A  88
 None
 1.39A 3iluH-1qlmA:
undetectable		 3iluH-1qlmA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		4 PRO A  28
SER A  25
LEU A 156
SER A  84
 None
 1.46A 3iluH-1qvbA:
undetectable		 3iluH-1qvbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus A) 		PF00073
(Rhv) 		4 PRO 2 226
SER 2  75
LEU 2 180
SER 2 171
 None
 1.46A 3iluH-1r1a2:
undetectable		 3iluH-1r1a2:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 PRO A 756
SER A 793
LEU A 802
SER A 803
 None
 1.24A 3iluH-1sojA:
undetectable		 3iluH-1sojA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 PRO A 342
SER A  86
LEU A 304
SER A 303
 None
 1.27A 3iluH-1ygpA:
undetectable		 3iluH-1ygpA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2doc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3) 		4 PRO A 112
SER A 114
LEU A  29
SER A  30
 None
 1.48A 3iluH-2docA:
undetectable		 3iluH-2docA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd6 H CHAIN OF FAB OF
ATN-615 ANTI-UPAR
ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS H  13
PRO H  14
SER H  84
SER H  82
 None
 1.48A 3iluH-2fd6H:
undetectable		 3iluH-2fd6H:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LYS A 331
SER A 334
LEU A 388
SER A 357
 None
 1.38A 3iluH-2gqdA:
undetectable		 3iluH-2gqdA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzx PUTATIVE TATD
RELATED DNASE

(Staphylococcus
aureus) 		PF01026
(TatD_DNase) 		4 LYS A 188
PRO A 187
SER A 154
LEU A 233
 None
 1.31A 3iluH-2gzxA:
undetectable		 3iluH-2gzxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzx PUTATIVE TATD
RELATED DNASE

(Staphylococcus
aureus) 		PF01026
(TatD_DNase) 		4 LYS A 188
PRO A 187
SER A 156
LEU A 233
 None
 1.37A 3iluH-2gzxA:
undetectable		 3iluH-2gzxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		no annotation 4 PRO G  29
SER G  31
LEU G 161
SER G 159
 None
 1.33A 3iluH-2ooxG:
undetectable		 3iluH-2ooxG:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		4 LYS A  35
PRO A  36
SER A  51
SER A 122
 None
None
IPA  A 141 ( 3.7A)
None
 1.08A 3iluH-2qo4A:
undetectable		 3iluH-2qo4A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsm HEMAGGLUTININ-NEURAM
INIDASE

(Nipah
henipavirus) 		PF00423
(HN) 		4 LYS A 391
PRO A 392
SER A 380
LEU A 397
 None
 1.16A 3iluH-2vsmA:
undetectable		 3iluH-2vsmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		4 PRO A 221
SER A 174
LEU A 226
SER A 224
 None
None
None
ZZU  A1359 (-3.2A)
 1.36A 3iluH-2wbpA:
undetectable		 3iluH-2wbpA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 PRO A 486
SER A 563
LEU A 353
SER A 376
 None
 1.45A 3iluH-2wpgA:
undetectable		 3iluH-2wpgA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA

(Escherichia
coli) 		PF13580
(SIS_2) 		4 LYS A  43
PRO A  75
SER A  73
LEU A  45
 None
 1.15A 3iluH-2yvaA:
undetectable		 3iluH-2yvaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22

(Homo sapiens) 		PF00225
(Kinesin) 		4 LYS A 213
PRO A 214
SER A 216
LEU A 188
 None
 1.48A 3iluH-3bfnA:
undetectable		 3iluH-3bfnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjz PHOSPHOHEPTOSE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13580
(SIS_2) 		4 LYS A  45
PRO A  77
SER A  75
LEU A  47
 None
 1.13A 3iluH-3bjzA:
undetectable		 3iluH-3bjzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjz PHOSPHOHEPTOSE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13580
(SIS_2) 		4 LYS A  45
PRO A  77
SER A  75
SER A  62
 None
 1.36A 3iluH-3bjzA:
undetectable		 3iluH-3bjzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxa SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 PRO A  25
SER A  22
LEU A  33
SER A 165
 None
 1.45A 3iluH-3fxaA:
undetectable		 3iluH-3fxaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfo COBALT IMPORT
ATP-BINDING PROTEIN
CBIO 1

(Clostridium
perfringens) 		PF00005
(ABC_tran) 		4 LYS A 137
PRO A 138
SER A  97
LEU A 134
 None
 1.22A 3iluH-3gfoA:
undetectable		 3iluH-3gfoA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LYS A 223
PRO A 224
LEU A 229
SER A 250
 None
 1.44A 3iluH-3gg4A:
undetectable		 3iluH-3gg4A:
18.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 LYS A 104
PRO A 105
LEU A 239
SER A 242
 None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
 0.35A 3iluH-3h6tA:
43.1		 3iluH-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 LYS A 104
PRO A 105
SER A 108
LEU A 239
 None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
 0.79A 3iluH-3h6tA:
43.1		 3iluH-3h6tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		4 PRO B 608
SER B 612
LEU B 658
SER B 663
 None
 1.49A 3iluH-3jb9B:
undetectable		 3iluH-3jb9B:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz2 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		4 LYS A 156
SER A  39
LEU A 316
SER A 314
 None
 1.41A 3iluH-3mz2A:
undetectable		 3iluH-3mz2A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE

(Enterobacter
cloacae) 		PF00328
(His_Phos_2) 		4 PRO A 200
SER A 198
LEU A 207
SER A 206
 None
 1.41A 3iluH-3ntlA:
undetectable		 3iluH-3ntlA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		4 PRO A 241
SER A  91
LEU A 185
SER A 187
 None
 1.40A 3iluH-3nx3A:
undetectable		 3iluH-3nx3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0x CENTRIOLE PROTEIN

(Chlamydomonas
reinhardtii) 		PF16531
(SAS-6_N) 		4 PRO A 103
SER A 101
LEU A 110
SER A 108
 None
 1.38A 3iluH-3q0xA:
undetectable		 3iluH-3q0xA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 PRO A 248
SER A 241
LEU A 282
SER A 284
 None
 1.45A 3iluH-3rreA:
undetectable		 3iluH-3rreA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 PRO A 358
SER A 400
LEU A 363
SER A 395
 None
 1.17A 3iluH-3v4pA:
undetectable		 3iluH-3v4pA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w8h SERINE/THREONINE-PRO
TEIN KINASE 25

(Homo sapiens) 		PF06840
(DUF1241) 		4 LYS B  -2
PRO B 398
SER B 396
SER B 401
 None
 1.13A 3iluH-3w8hB:
undetectable		 3iluH-3w8hB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 PRO A 575
SER A 197
LEU A 555
SER A 556
 None
 1.03A 3iluH-3wkyA:
undetectable		 3iluH-3wkyA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		4 LYS A  71
PRO A  72
SER A  74
SER A 135
 None
None
SO4  A1332 (-4.8A)
None
 1.36A 3iluH-4aa9A:
undetectable		 3iluH-4aa9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bem F1FO ATPASE C1
SUBUNIT

(Acetobacterium
woodii) 		PF00137
(ATP-synt_C) 		4 PRO J  20
SER J  16
LEU J 108
SER J 109
 None
 1.35A 3iluH-4bemJ:
undetectable		 3iluH-4bemJ:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		4 PRO A 344
SER A  89
LEU A 309
SER A 308
 None
 1.30A 3iluH-4bqiA:
undetectable		 3iluH-4bqiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL

(Homo sapiens) 		PF00753
(Lactamase_B) 		4 PRO A 137
SER A 106
LEU A 174
SER A 132
 None
 1.41A 3iluH-4chlA:
undetectable		 3iluH-4chlA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LYS A1016
SER A1149
LEU A1177
SER A1174
 None
 1.00A 3iluH-4e9xA:
undetectable		 3iluH-4e9xA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebz CHITIN ELICITOR
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF01476
(LysM) 		4 LYS A  25
SER A 159
LEU A  99
SER A 154
 None
 1.27A 3iluH-4ebzA:
undetectable		 3iluH-4ebzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyc CATHELICIDIN
ANTIMICROBIAL
PEPTIDE

(Homo sapiens) 		PF00666
(Cathelicidins) 		4 LYS A  75
PRO A  76
SER A  78
LEU A 114
 None
 1.18A 3iluH-4eycA:
undetectable		 3iluH-4eycA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		4 PRO A 213
SER A 192
LEU A 239
SER A 238
 None
 1.09A 3iluH-4fs7A:
undetectable		 3iluH-4fs7A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iej DNA
METHYLTRANSFERASE
1-ASSOCIATED PROTEIN
1

(Homo sapiens) 		PF16282
(SANT_DAMP1_like) 		4 LYS A 133
PRO A 136
LEU A 169
SER A 164
 None
 1.46A 3iluH-4iejA:
undetectable		 3iluH-4iejA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF13646
(HEAT_2) 		4 LYS A 226
SER A 261
LEU A 230
SER A 233
 None
 1.32A 3iluH-4l7mA:
undetectable		 3iluH-4l7mA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnz PROBABLE ZINC
PROTEASE

(Pseudomonas
aeruginosa) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LYS A 224
SER A  39
LEU A 226
SER A 156
 PEG  A 501 (-3.1A)
None
None
None
 1.20A 3iluH-4nnzA:
undetectable		 3iluH-4nnzA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		4 LYS A 117
SER A 326
LEU A 121
SER A 123
 None
 1.25A 3iluH-4o8mA:
9.2		 3iluH-4o8mA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		4 PRO A 212
SER A 194
LEU A 235
SER A 234
 None
 1.42A 3iluH-4ow2A:
undetectable		 3iluH-4ow2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		4 LYS A 179
PRO A 180
SER A 200
SER A 191
 None
 1.49A 3iluH-4rp8A:
undetectable		 3iluH-4rp8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 PRO A 179
SER A 160
LEU A 206
SER A 205
 None
 1.31A 3iluH-4v2dA:
undetectable		 3iluH-4v2dA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgy GREEN FLUORESCENT
PROTEIN, MAB LCDR3,
GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vibrio
parahaemolyticus;
synthetic
construct) 		PF01353
(GFP) 		4 LYS A  41
SER A 215
LEU A 234
SER A 218
 PE5  A 301 (-2.5A)
None
PE5  A 301 (-4.1A)
CRO  A  66 ( 3.2A)
 1.48A 3iluH-4xgyA:
undetectable		 3iluH-4xgyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 LYS A 369
SER A 337
LEU A 220
SER A 217
 None
 1.39A 3iluH-4xqkA:
undetectable		 3iluH-4xqkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx8 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		4 PRO A 110
SER A  78
LEU A 181
SER A 184
 None
 1.37A 3iluH-4yx8A:
undetectable		 3iluH-4yx8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 PRO A 229
SER A 227
LEU A 260
SER A 259
 None
CNC  A 501 (-3.2A)
None
None
 1.39A 3iluH-4zrqA:
undetectable		 3iluH-4zrqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a24 DIONAIN-1

(Dionaea
muscipula) 		PF00112
(Peptidase_C1) 		4 PRO A 109
SER A 105
LEU A  49
SER A  50
 None
 1.21A 3iluH-5a24A:
undetectable		 3iluH-5a24A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 PRO A 404
SER A 406
LEU A 396
SER A 542
 None
 1.29A 3iluH-5a7mA:
undetectable		 3iluH-5a7mA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1

(Homo sapiens) 		no annotation 4 LYS A  13
PRO A  14
SER A  30
SER A  67
 None
 1.27A 3iluH-5aj1A:
undetectable		 3iluH-5aj1A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		4 LYS K 493
PRO K 494
SER K 489
LEU K 496
 None
 1.28A 3iluH-5anbK:
undetectable		 3iluH-5anbK:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		4 PRO A 414
SER A 419
LEU A 409
SER A 408
 None
None
None
NAP  A 601 ( 4.0A)
 1.28A 3iluH-5d2eA:
undetectable		 3iluH-5d2eA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 PRO A 129
SER A 189
LEU A 108
SER A 112
 None
 1.49A 3iluH-5djqA:
undetectable		 3iluH-5djqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3j ANTIBODY 2D10 SINGLE
CHAIN VARIABLE
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 LYS C 182
PRO C 183
SER C 257
SER C 254
 None
 1.39A 3iluH-5f3jC:
undetectable		 3iluH-5f3jC:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		4 PRO A 182
SER A 149
LEU A  68
SER A  71
 None
 1.16A 3iluH-5fyaA:
undetectable		 3iluH-5fyaA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gve DNA TOPOISOMERASE
3-BETA-1

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 LYS A  10
PRO A  11
SER A  37
SER A  16
 None
 1.09A 3iluH-5gveA:
undetectable		 3iluH-5gveA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		4 PRO A 212
SER A  51
LEU A 218
SER A 217
 None
SR  A 401 ( 4.2A)
TOE  A 410 (-4.1A)
None
 1.41A 3iluH-5hxsA:
undetectable		 3iluH-5hxsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
coronavirus
HKU1;
Human
immunodeficiency
virus 1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 LYS A 809
SER A 914
LEU A 850
SER A 806
 None
 1.45A 3iluH-5i08A:
undetectable		 3iluH-5i08A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LYS A 245
PRO A 247
SER A 249
SER A 552
 None
 1.49A 3iluH-5i8iA:
undetectable		 3iluH-5i8iA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 LYS A 169
PRO A 168
SER A 165
SER A 240
 None
 1.40A 3iluH-5jn9A:
undetectable		 3iluH-5jn9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 PRO A 613
SER A 418
LEU A 699
SER A 697
 None
 1.50A 3iluH-5jp0A:
undetectable		 3iluH-5jp0A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens) 		PF00452
(Bcl-2) 		4 PRO A 289
SER A 285
LEU A 179
SER A 183
 None
 1.23A 3iluH-5jsbA:
undetectable		 3iluH-5jsbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh1 INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 PRO A 118
SER A 100
LEU A 141
SER A 140
 None
 1.35A 3iluH-5kh1A:
undetectable		 3iluH-5kh1A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh1 INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 PRO A 158
SER A 140
LEU A 181
SER A 180
 None
 1.17A 3iluH-5kh1A:
undetectable		 3iluH-5kh1A:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 LYS A 493
PRO A 494
LEU A 751
SER A 754
 None
 0.44A 3iluH-5l1bA:
22.3		 3iluH-5l1bA:
70.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcl DNA REPAIR PROTEIN
RAD14

(Saccharomyces
cerevisiae) 		PF05181
(XPA_C) 		4 LYS A 254
PRO A 255
SER A 259
LEU A 267
 None
 1.43A 3iluH-5lclA:
undetectable		 3iluH-5lclA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcl DNA REPAIR PROTEIN
RAD14

(Saccharomyces
cerevisiae) 		PF05181
(XPA_C) 		4 LYS B 254
PRO B 255
SER B 259
LEU B 267
 None
 1.41A 3iluH-5lclB:
undetectable		 3iluH-5lclB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 LYS A 922
SER A 907
LEU A 926
SER A 929
 None
 1.36A 3iluH-5lewA:
undetectable		 3iluH-5lewA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo sapiens) 		no annotation 4 PRO A 319
SER A 316
LEU A 323
SER A 322
 None
None
None
SAM  A 501 (-2.7A)
 1.41A 3iluH-5nfjA:
undetectable		 3iluH-5nfjA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viy BG1 FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS G 149
SER G 177
LEU G 154
SER G 156
 None
 1.49A 3iluH-5viyG:
undetectable		 3iluH-5viyG:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LYS A 710
PRO A 711
SER A 745
LEU A 673
 None
 1.44A 3iluH-5vywA:
undetectable		 3iluH-5vywA:
13.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 LYS A 493
PRO A 494
LEU A 751
SER A 754
 None
 0.73A 3iluH-5welA:
32.4		 3iluH-5welA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
PRO A 494
SER A 497
LEU A 751
SER A 754
 None
CYZ  A1302 (-4.5A)
CYZ  A1302 (-3.2A)
None
CYZ  A1302 ( 4.1A)
 0.97A 3iluH-5weoA:
25.0		 3iluH-5weoA:
66.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 LYS A 205
PRO A 207
SER A 217
LEU A 283
 MLY  A 204 ( 3.3A)
None
None
None
 1.31A 3iluH-5z5cA:
undetectable		 3iluH-5z5cA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 PRO A 219
SER A 199
LEU A 246
SER A 245
 None
 1.25A 3iluH-5zlnA:
undetectable		 3iluH-5zlnA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 4 LYS B 153
SER B 431
LEU B 149
SER B 435
 None
 1.43A 3iluH-6btmB:
undetectable		 3iluH-6btmB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 4 LYS 1 275
SER 1 151
LEU 1 271
SER 1 269
 None
 1.12A 3iluH-6c261:
undetectable		 3iluH-6c261:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ghc -

(-) 		no annotation 4 LYS A 168
SER A 171
LEU A 148
SER A 149
 None
 1.40A 3iluH-6ghcA:
undetectable		 3iluH-6ghcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gup -

(-) 		no annotation 4 PRO A 239
SER A 241
LEU A 234
SER A 235
 None
 1.47A 3iluH-6gupA:
undetectable		 3iluH-6gupA:
undetectable