SIMILAR PATTERNS OF AMINO ACIDS FOR 3ILT_H_TRUH800_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR


(Escherichia
coli)
PF12849
(PBP_like_2)
3 ILE A  45
SER A  55
SER A  39
None
0.54A 3iltH-1a40A:
5.2
3iltH-1a40A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)


(Deinagkistrodon
acutus)
PF01421
(Reprolysin)
3 ILE A 138
SER A 171
SER A 169
None
0.54A 3iltH-1budA:
undetectable
3iltH-1budA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4v TNF-RELATED
APOPTOSIS INDUCING
LIGAND


(Homo sapiens)
PF00229
(TNF)
3 ILE B 126
SER B 186
SER B 273
None
0.50A 3iltH-1d4vB:
undetectable
3iltH-1d4vB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dg6 APO2L/TNF-RELATED
APOPOTIS INDUCING
LIGAND (TRAIL)


(Homo sapiens)
PF00229
(TNF)
3 ILE A 126
SER A 186
SER A 273
None
0.53A 3iltH-1dg6A:
undetectable
3iltH-1dg6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvf FV E5.2

(Mus musculus)
PF07686
(V-set)
3 ILE C  83
SER C  12
SER C  14
None
0.59A 3iltH-1dvfC:
undetectable
3iltH-1dvfC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gco GLUCOSE
DEHYDROGENASE


(Bacillus
megaterium)
PF13561
(adh_short_C2)
3 ILE A  25
SER A  47
SER A  16
None
None
NAD  A 601 ( 3.9A)
0.60A 3iltH-1gcoA:
undetectable
3iltH-1gcoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E


(Cellvibrio
japonicus)
PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M)
3 ILE A 115
SER A 145
SER A 147
None
0.49A 3iltH-1gqjA:
1.1
3iltH-1gqjA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE


(Escherichia
coli)
PF01380
(SIS)
3 ILE A 574
SER A 306
SER A 310
None
0.62A 3iltH-1morA:
undetectable
3iltH-1morA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wey CALCIPRESSIN 1

(Mus musculus)
PF04847
(Calcipressin)
3 ILE A  51
SER A  58
SER A  54
None
0.49A 3iltH-1weyA:
undetectable
3iltH-1weyA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wtl BENCE-JONES PROTEIN
MCG (LIGHT CHAIN)


(Homo sapiens)
PF07686
(V-set)
3 ILE A  83
SER A  12
SER A  14
None
0.43A 3iltH-1wtlA:
undetectable
3iltH-1wtlA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133


(Homo sapiens)
no annotation 3 ILE A 221
SER A 288
SER A 227
None
0.61A 3iltH-1xksA:
undetectable
3iltH-1xksA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 ILE A 221
SER A 235
SER A 231
None
0.60A 3iltH-1yb5A:
undetectable
3iltH-1yb5A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN


(Mus musculus)
PF07686
(V-set)
3 ILE L  48
SER L  74
SER L  72
None
GOL  L5001 (-2.7A)
GOL  L5001 ( 4.4A)
0.56A 3iltH-2e27L:
undetectable
3iltH-2e27L:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1


(Mus musculus)
PF00120
(Gln-synt_C)
3 ILE A  88
SER A  28
SER A  30
None
0.57A 3iltH-2j9iA:
undetectable
3iltH-2j9iA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzw UNCHARACTERIZED
PROTEIN


(Methanosarcina
mazei)
PF00801
(PKD)
PF05048
(NosD)
3 ILE A 121
SER A 101
SER A  90
None
0.65A 3iltH-2kzwA:
undetectable
3iltH-2kzwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE


(Shewanella
frigidimarina)
PF04820
(Trp_halogenase)
3 ILE A 286
SER A  91
SER A 275
None
0.54A 3iltH-2pyxA:
undetectable
3iltH-2pyxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg3 UPF0130 PROTEIN
AF_2059


(Archaeoglobus
fulgidus)
PF02676
(TYW3)
3 ILE A 136
SER A  45
SER A  47
None
0.57A 3iltH-2qg3A:
undetectable
3iltH-2qg3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xnq NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3


(Saccharomyces
cerevisiae)
PF00076
(RRM_1)
3 ILE A 369
SER A 376
SER A 330
None
0.46A 3iltH-2xnqA:
undetectable
3iltH-2xnqA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN


(Yersinia pestis)
no annotation 3 ILE X  45
SER X  55
SER X  39
None
0.57A 3iltH-2z22X:
9.0
3iltH-2z22X:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl3 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT


(Helicobacter
pylori)
PF00574
(CLP_protease)
3 ILE A  78
SER A  44
SER A  40
None
0.59A 3iltH-2zl3A:
undetectable
3iltH-2zl3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
3 ILE A 379
SER A 370
SER A  36
None
0.54A 3iltH-2zyjA:
undetectable
3iltH-2zyjA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN


(Escherichia
coli)
PF05985
(EutC)
3 ILE B 174
SER B 239
SER B 237
None
0.61A 3iltH-3absB:
undetectable
3iltH-3absB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN


(Escherichia
coli)
PF05985
(EutC)
3 ILE B 174
SER B 239
SER B 237
None
B12  B 601 ( 4.6A)
None
0.58A 3iltH-3anyB:
undetectable
3iltH-3anyB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayq LYSOZYME

(Meretrix
lusoria)
PF05497
(Destabilase)
3 ILE A  40
SER A  61
SER A  57
NAG  A 125 (-4.4A)
None
None
0.52A 3iltH-3ayqA:
undetectable
3iltH-3ayqA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bnk FLAVOREDOXIN

(Methanosarcina
acetivorans)
PF01613
(Flavin_Reduct)
3 ILE A 138
SER A  66
SER A  68
None
0.50A 3iltH-3bnkA:
undetectable
3iltH-3bnkA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ILE A 757
SER A 597
SER A 762
None
0.51A 3iltH-3c4fA:
undetectable
3iltH-3c4fA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdf IMMUNOGLOBULIN LIGHT
CHAIN


(Homo sapiens)
PF07686
(V-set)
3 ILE A  83
SER A  12
SER A  14
None
0.56A 3iltH-3cdfA:
undetectable
3iltH-3cdfA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY


(Enterococcus
faecalis)
PF01408
(GFO_IDH_MocA)
3 ILE A 248
SER A 151
SER A 235
None
0.63A 3iltH-3e9mA:
undetectable
3iltH-3e9mA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg4 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E


(Brucella suis)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2)
3 ILE A 171
SER A 195
SER A 166
None
0.58A 3iltH-3eg4A:
undetectable
3iltH-3eg4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE


(Porphyromonas
gingivalis)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
3 ILE A 357
SER A 324
SER A 329
None
0.61A 3iltH-3eh7A:
undetectable
3iltH-3eh7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqk PRENECK APPENDAGE
PROTEIN


(Bacillus virus
phi29)
PF11962
(Peptidase_G2)
3 ILE A 787
SER A 790
SER A 743
ATP  A   1 (-3.6A)
None
None
0.65A 3iltH-3gqkA:
undetectable
3iltH-3gqkA:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
3 ILE A  92
SER A 108
SER A 217
None
CYZ  A 265 (-2.8A)
GOL  A 270 ( 3.0A)
0.42A 3iltH-3h6tA:
36.8
3iltH-3h6tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus)
PF01766
(Birna_VP2)
3 ILE A  64
SER A  86
SER A  40
None
0.58A 3iltH-3ideA:
undetectable
3iltH-3ideA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksu 3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE


(Oenococcus oeni)
PF13561
(adh_short_C2)
3 ILE A 128
SER A 174
SER A 183
None
0.60A 3iltH-3ksuA:
undetectable
3iltH-3ksuA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntc FAB LIGHT CHAIN

(Homo sapiens;
Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 ILE L  83
SER L  12
SER L  14
None
0.48A 3iltH-3ntcL:
undetectable
3iltH-3ntcL:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1


(Anopheles
gambiae)
PF00560
(LRR_1)
3 ILE A 123
SER A 139
SER A 137
None
0.61A 3iltH-3ojaA:
undetectable
3iltH-3ojaA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE


(Thermotoga
maritima)
PF00793
(DAHP_synth_1)
3 ILE A 181
SER A 199
SER A 195
None
AZI  A   6 (-2.8A)
None
0.61A 3iltH-3pg8A:
undetectable
3iltH-3pg8A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE


(Aliivibrio
fischeri)
PF02719
(Polysacc_synt_2)
3 ILE A  52
SER A  33
SER A  31
None
0.58A 3iltH-3pvzA:
undetectable
3iltH-3pvzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE


(Tenebrio
molitor)
PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29)
3 ILE A 174
SER A 154
SER A 169
None
0.65A 3iltH-3qt4A:
undetectable
3iltH-3qt4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE


(Campylobacter
jejuni)
PF00709
(Adenylsucc_synt)
3 ILE A 415
SER A 324
SER A 405
None
0.56A 3iltH-3r7tA:
undetectable
3iltH-3r7tA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA


(Mycobacterium
tuberculosis)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
3 ILE A 171
SER A 196
SER A 194
None
0.54A 3iltH-3rb9A:
undetectable
3iltH-3rb9A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE


(Proteus
mirabilis)
PF02126
(PTE)
3 ILE A 105
SER A 123
SER A  98
None
0.56A 3iltH-3rhgA:
undetectable
3iltH-3rhgA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E


(Burkholderia
pseudomallei)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2)
3 ILE A 203
SER A 227
SER A 198
None
0.64A 3iltH-3tk8A:
undetectable
3iltH-3tk8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ILE A 757
SER A 597
SER A 762
None
0.50A 3iltH-3tt0A:
undetectable
3iltH-3tt0A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C)
3 ILE B 932
SER B1007
SER B 918
None
0.63A 3iltH-3v0aB:
undetectable
3iltH-3v0aB:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0w WN1 222-5 FAB
(IGG2A) LIGHT CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 ILE L  83
SER L  12
SER L  14
None
0.53A 3iltH-3v0wL:
undetectable
3iltH-3v0wL:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311


(Methanocaldococcus
jannaschii)
PF01261
(AP_endonuc_2)
3 ILE A 264
SER A  34
SER A  23
None
0.49A 3iltH-3wqoA:
undetectable
3iltH-3wqoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1


(Toxoplasma
gondii)
PF01150
(GDA1_CD39)
3 ILE A  95
SER A  62
SER A  87
None
0.59A 3iltH-4a5aA:
undetectable
3iltH-4a5aA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auo INTERSTITIAL
COLLAGENASE


(Homo sapiens)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
3 ILE A 234
SER A 244
SER A 123
None
0.61A 3iltH-4auoA:
undetectable
3iltH-4auoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli)
PF00350
(Dynamin_N)
3 ILE A 314
SER A 389
SER A 393
None
0.65A 3iltH-4aurA:
undetectable
3iltH-4aurA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A


(Oryza sativa)
PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3)
3 ILE A 439
SER A 394
SER A 398
None
0.64A 3iltH-4b8jA:
undetectable
3iltH-4b8jA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2


(Saccharomyces
cerevisiae)
PF04153
(NOT2_3_5)
3 ILE B  43
SER B  40
SER B  36
None
0.59A 3iltH-4by6B:
undetectable
3iltH-4by6B:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dry 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Sinorhizobium
meliloti)
PF00106
(adh_short)
3 ILE A  39
SER A  31
SER A  36
None
0.57A 3iltH-4dryA:
undetectable
3iltH-4dryA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN


(Clostridium
perfringens)
PF12849
(PBP_like_2)
3 ILE A  75
SER A  41
SER A 159
None
PO4  A 301 (-2.5A)
PO4  A 301 (-2.7A)
0.48A 3iltH-4gd5A:
12.0
3iltH-4gd5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE


(Pasteurella
multocida)
PF00701
(DHDPS)
3 ILE A 126
SER A 102
SER A 104
None
0.63A 3iltH-4imdA:
undetectable
3iltH-4imdA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq6 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE


([Candida]
glabrata)
PF00885
(DMRL_synthase)
3 ILE A 110
SER A  61
SER A 103
None
0.57A 3iltH-4kq6A:
2.5
3iltH-4kq6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC


(Solanum
lycopersicum)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
3 ILE A 241
SER A 200
SER A 196
None
0.55A 3iltH-4ksiA:
undetectable
3iltH-4ksiA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlz PERIPLASMIC BINDING
PROTEIN


(Jonesia
denitrificans)
PF01497
(Peripla_BP_2)
3 ILE A 198
SER A 213
SER A 209
None
0.63A 3iltH-4mlzA:
undetectable
3iltH-4mlzA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nef AQUAPORIN-2

(Homo sapiens)
PF00230
(MIP)
3 ILE A  52
SER A 167
SER A 163
None
None
CD  A 301 ( 4.4A)
0.57A 3iltH-4nefA:
undetectable
3iltH-4nefA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6


(Trypanosoma
brucei)
PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1)
3 ILE A 473
SER A 499
SER A 495
None
0.59A 3iltH-4nlbA:
undetectable
3iltH-4nlbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF00171
(Aldedh)
3 ILE A 415
SER A 454
SER A 436
None
0.40A 3iltH-4oe5A:
undetectable
3iltH-4oe5A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj2 AQUAPORIN-2

(Homo sapiens)
PF00230
(MIP)
3 ILE X  52
SER X 167
SER X 163
None
0.60A 3iltH-4oj2X:
undetectable
3iltH-4oj2X:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120)
no annotation 3 ILE A 496
SER A 471
SER A 499
None
0.63A 3iltH-4oj5A:
undetectable
3iltH-4oj5A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7y METHIONINE
GAMMA-LYASE


(Citrobacter
freundii)
PF01053
(Cys_Met_Meta_PP)
3 ILE A 129
SER A 123
SER A 121
None
0.58A 3iltH-4p7yA:
undetectable
3iltH-4p7yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN


(Clostridium
perfringens)
PF12849
(PBP_like_2)
3 ILE A  45
SER A  11
SER A 129
None
PO4  A 301 (-2.5A)
PO4  A 301 (-2.6A)
0.45A 3iltH-4q8rA:
12.1
3iltH-4q8rA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN


(Agrobacterium
tumefaciens)
PF00884
(Sulfatase)
PF16347
(DUF4976)
3 ILE A 290
SER A 226
SER A 181
None
0.49A 3iltH-4uphA:
undetectable
3iltH-4uphA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w60 LATE PROTEIN H7

(Vaccinia virus)
PF04787
(Pox_H7)
3 ILE A  93
SER A  30
SER A  98
None
0.60A 3iltH-4w60A:
undetectable
3iltH-4w60A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x22 TRIOSEPHOSPHATE
ISOMERASE


(Leptospira
interrogans)
PF00121
(TIM)
3 ILE A 196
SER A 209
SER A 205
None
0.57A 3iltH-4x22A:
undetectable
3iltH-4x22A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
3 ILE A 134
SER A 140
SER A 137
None
0.60A 3iltH-4zktA:
undetectable
3iltH-4zktA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ILE A 757
SER A 597
SER A 762
None
0.63A 3iltH-5a46A:
undetectable
3iltH-5a46A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans)
no annotation 3 ILE A  21
SER A 396
SER A  18
None
0.46A 3iltH-5ah0A:
undetectable
3iltH-5ah0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON


(Schizosaccharomyces
pombe)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
3 ILE I 327
SER I 343
SER I 324
None
0.64A 3iltH-5b04I:
undetectable
3iltH-5b04I:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5x AQUAPORIN-5

(Homo sapiens)
PF00230
(MIP)
3 ILE A  53
SER A 168
SER A 164
None
0.51A 3iltH-5c5xA:
undetectable
3iltH-5c5xA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edj FRPC OPERON PROTEIN

(Neisseria
meningitidis)
PF06901
(FrpC)
3 ILE A 239
SER A 221
SER A 223
None
0.53A 3iltH-5edjA:
undetectable
3iltH-5edjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB


(Mus musculus)
PF00784
(MyTH4)
3 ILE A1262
SER A1198
SER A1218
None
0.55A 3iltH-5f3yA:
undetectable
3iltH-5f3yA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2


(Homo sapiens)
PF00012
(HSP70)
3 ILE A  67
SER A 120
SER A  40
None
0.55A 3iltH-5fpnA:
undetectable
3iltH-5fpnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN


(Lampetra
fluviatilis)
PF00079
(Serpin)
3 ILE A 241
SER A 177
SER A 238
None
0.64A 3iltH-5inwA:
undetectable
3iltH-5inwA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F


(Escherichia
coli)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
3 ILE A 872
SER A 604
SER A 606
None
0.61A 3iltH-5ja1A:
undetectable
3iltH-5ja1A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE


(Paraburkholderia
xenovorans)
PF00155
(Aminotran_1_2)
3 ILE A 305
SER A 369
SER A 371
None
0.61A 3iltH-5jayA:
undetectable
3iltH-5jayA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2)
3 ILE A 452
SER A 445
SER A 443
None
0.63A 3iltH-5jqkA:
undetectable
3iltH-5jqkA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyl SCFV TSP7

(Mus musculus)
PF07686
(V-set)
3 ILE B 221
SER B 150
SER B 152
None
0.40A 3iltH-5jylB:
undetectable
3iltH-5jylB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzg CAPSID PROTEIN VP0

(Rhinovirus C)
PF00073
(Rhv)
PF02226
(Pico_P1A)
3 ILE C 270
SER C  67
SER C  69
None
0.61A 3iltH-5jzgC:
undetectable
3iltH-5jzgC:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kay SPELTER

(unidentified)
PF00669
(Flagellin_N)
3 ILE A  86
SER A  29
SER A  25
None
0.61A 3iltH-5kayA:
undetectable
3iltH-5kayA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN


(Clostridium
perfringens)
no annotation 3 ILE B1000
SER B 943
SER B 941
None
0.62A 3iltH-5kdjB:
undetectable
3iltH-5kdjB:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov PL-2 SCFV CHAIN

(Mus musculus)
PF07686
(V-set)
3 ILE C1083
SER C1012
SER C1014
None
0.50A 3iltH-5kovC:
undetectable
3iltH-5kovC:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1


(Arabidopsis
thaliana)
PF00400
(WD40)
3 ILE A 373
SER A 424
SER A 376
None
0.62A 3iltH-5kwnA:
undetectable
3iltH-5kwnA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1


(Arabidopsis
thaliana)
PF00400
(WD40)
3 ILE A 395
SER A 376
SER A 424
None
0.59A 3iltH-5kwnA:
undetectable
3iltH-5kwnA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkm DNA REPAIR PROTEIN
RADA


(Streptococcus
pneumoniae)
PF13481
(AAA_25)
PF13541
(ChlI)
3 ILE A 168
SER A 122
SER A 171
None
0.47A 3iltH-5lkmA:
undetectable
3iltH-5lkmA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1


(Trypanosoma
brucei)
PF00913
(Trypan_glycop)
3 ILE A 105
SER A  22
SER A 148
None
0.63A 3iltH-5ly9A:
undetectable
3iltH-5ly9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42


(Saccharomyces
cerevisiae)
no annotation 3 ILE D 486
SER D 491
SER D 449
None
0.61A 3iltH-5uz5D:
undetectable
3iltH-5uz5D:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1


(Arabidopsis
thaliana)
no annotation 3 ILE A1275
SER A1012
SER A1010
None
0.55A 3iltH-5wblA:
undetectable
3iltH-5wblA:
14.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN


(Mus musculus;
Rattus
norvegicus)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd)
3 ILE A 481
SER A 497
SER A 729
None
0.32A 3iltH-5welA:
28.5
3iltH-5welA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA


(Mus musculus;
Rattus
norvegicus)
PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
3 ILE A 481
SER A 497
SER A 729
None
CYZ  A1302 (-3.2A)
None
0.39A 3iltH-5weoA:
21.0
3iltH-5weoA:
66.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnn PHOSPHATE-BINDING
PROTEIN PSTS


(Burkholderia
pseudomallei)
PF12849
(PBP_like_2)
3 ILE A  65
SER A  75
SER A  59
None
0.50A 3iltH-5wnnA:
5.0
3iltH-5wnnA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC


(Umbellularia
californica)
no annotation 3 ILE A 189
SER A 219
SER A 217
None
0.64A 3iltH-5x04A:
undetectable
3iltH-5x04A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD


(Deinococcus
radiodurans)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
3 ILE A 694
SER A 667
SER A 671
None
0.64A 3iltH-5xapA:
undetectable
3iltH-5xapA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S3, PUTATIVE


(Trichomonas
vaginalis)
PF00189
(Ribosomal_S3_C)
PF07650
(KH_2)
3 ILE D 183
SER D 151
SER D 149
None
0.59A 3iltH-5xyiD:
undetectable
3iltH-5xyiD:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E


(Acinetobacter
baumannii)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2)
3 ILE A 164
SER A 188
SER A 159
None
0.64A 3iltH-6amzA:
undetectable
3iltH-6amzA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E


(Legionella
pneumophila)
no annotation 3 ILE A 164
SER A 188
SER A 159
None
0.62A 3iltH-6cktA:
undetectable
3iltH-6cktA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epe PROTEASOME SUBUNIT
BETA TYPE-1


(Rattus
norvegicus)
no annotation 3 ILE 6 115
SER 6 161
SER 6 150
None
0.46A 3iltH-6epe6:
undetectable
3iltH-6epe6:
17.02