SIMILAR PATTERNS OF AMINO ACIDS FOR 3ILT_H_TRUH800_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a40 | PHOSPHATE-BINDINGPERIPLASMIC PROTEINPRECURSOR (Escherichiacoli) |
PF12849(PBP_like_2) | 3 | ILE A 45SER A 55SER A 39 | None | 0.54A | 3iltH-1a40A:5.2 | 3iltH-1a40A:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bud | PROTEIN (ACUTOLYSINA) (Deinagkistrodonacutus) |
PF01421(Reprolysin) | 3 | ILE A 138SER A 171SER A 169 | None | 0.54A | 3iltH-1budA:undetectable | 3iltH-1budA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d4v | TNF-RELATEDAPOPTOSIS INDUCINGLIGAND (Homo sapiens) |
PF00229(TNF) | 3 | ILE B 126SER B 186SER B 273 | None | 0.50A | 3iltH-1d4vB:undetectable | 3iltH-1d4vB:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dg6 | APO2L/TNF-RELATEDAPOPOTIS INDUCINGLIGAND (TRAIL) (Homo sapiens) |
PF00229(TNF) | 3 | ILE A 126SER A 186SER A 273 | None | 0.53A | 3iltH-1dg6A:undetectable | 3iltH-1dg6A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dvf | FV E5.2 (Mus musculus) |
PF07686(V-set) | 3 | ILE C 83SER C 12SER C 14 | None | 0.59A | 3iltH-1dvfC:undetectable | 3iltH-1dvfC:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gco | GLUCOSEDEHYDROGENASE (Bacillusmegaterium) |
PF13561(adh_short_C2) | 3 | ILE A 25SER A 47SER A 16 | NoneNoneNAD A 601 ( 3.9A) | 0.60A | 3iltH-1gcoA:undetectable | 3iltH-1gcoA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gqj | ALPHA-D-GLUCURONIDASE (Cellvibriojaponicus) |
PF03648(Glyco_hydro_67N)PF07477(Glyco_hydro_67C)PF07488(Glyco_hydro_67M) | 3 | ILE A 115SER A 145SER A 147 | None | 0.49A | 3iltH-1gqjA:1.1 | 3iltH-1gqjA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mor | GLUCOSAMINE6-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF01380(SIS) | 3 | ILE A 574SER A 306SER A 310 | None | 0.62A | 3iltH-1morA:undetectable | 3iltH-1morA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wey | CALCIPRESSIN 1 (Mus musculus) |
PF04847(Calcipressin) | 3 | ILE A 51SER A 58SER A 54 | None | 0.49A | 3iltH-1weyA:undetectable | 3iltH-1weyA:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wtl | BENCE-JONES PROTEINMCG (LIGHT CHAIN) (Homo sapiens) |
PF07686(V-set) | 3 | ILE A 83SER A 12SER A 14 | None | 0.43A | 3iltH-1wtlA:undetectable | 3iltH-1wtlA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xks | NUCLEAR PORE COMPLEXPROTEIN NUP133 (Homo sapiens) |
no annotation | 3 | ILE A 221SER A 288SER A 227 | None | 0.61A | 3iltH-1xksA:undetectable | 3iltH-1xksA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yb5 | QUINONEOXIDOREDUCTASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | ILE A 221SER A 235SER A 231 | None | 0.60A | 3iltH-1yb5A:undetectable | 3iltH-1yb5A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e27 | ANTI-CIGUATOXINANTIBODY, LIGHTCHAIN (Mus musculus) |
PF07686(V-set) | 3 | ILE L 48SER L 74SER L 72 | NoneGOL L5001 (-2.7A)GOL L5001 ( 4.4A) | 0.56A | 3iltH-2e27L:undetectable | 3iltH-2e27L:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j9i | GLUTAMATE-AMMONIALIGASEDOMAIN-CONTAININGPROTEIN 1 (Mus musculus) |
PF00120(Gln-synt_C) | 3 | ILE A 88SER A 28SER A 30 | None | 0.57A | 3iltH-2j9iA:undetectable | 3iltH-2j9iA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kzw | UNCHARACTERIZEDPROTEIN (Methanosarcinamazei) |
PF00801(PKD)PF05048(NosD) | 3 | ILE A 121SER A 101SER A 90 | None | 0.65A | 3iltH-2kzwA:undetectable | 3iltH-2kzwA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyx | TRYPTOPHANHALOGENASE (Shewanellafrigidimarina) |
PF04820(Trp_halogenase) | 3 | ILE A 286SER A 91SER A 275 | None | 0.54A | 3iltH-2pyxA:undetectable | 3iltH-2pyxA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qg3 | UPF0130 PROTEINAF_2059 (Archaeoglobusfulgidus) |
PF02676(TYW3) | 3 | ILE A 136SER A 45SER A 47 | None | 0.57A | 3iltH-2qg3A:undetectable | 3iltH-2qg3A:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xnq | NUCLEARPOLYADENYLATEDRNA-BINDING PROTEIN3 (Saccharomycescerevisiae) |
PF00076(RRM_1) | 3 | ILE A 369SER A 376SER A 330 | None | 0.46A | 3iltH-2xnqA:undetectable | 3iltH-2xnqA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z22 | PERIPLASMICPHOSPHATE-BINDINGPROTEIN (Yersinia pestis) |
no annotation | 3 | ILE X 45SER X 55SER X 39 | None | 0.57A | 3iltH-2z22X:9.0 | 3iltH-2z22X:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zl3 | ATP-DEPENDENT CLPPROTEASE PROTEOLYTICSUBUNIT (Helicobacterpylori) |
PF00574(CLP_protease) | 3 | ILE A 78SER A 44SER A 40 | None | 0.59A | 3iltH-2zl3A:undetectable | 3iltH-2zl3A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zyj | ALPHA-AMINODIPATEAMINOTRANSFERASE (Thermusthermophilus) |
PF00155(Aminotran_1_2) | 3 | ILE A 379SER A 370SER A 36 | None | 0.54A | 3iltH-2zyjA:undetectable | 3iltH-2zyjA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abs | ETHANOLAMINEAMMONIA-LYASE LIGHTCHAIN (Escherichiacoli) |
PF05985(EutC) | 3 | ILE B 174SER B 239SER B 237 | None | 0.61A | 3iltH-3absB:undetectable | 3iltH-3absB:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3any | ETHANOLAMINEAMMONIA-LYASE LIGHTCHAIN (Escherichiacoli) |
PF05985(EutC) | 3 | ILE B 174SER B 239SER B 237 | NoneB12 B 601 ( 4.6A)None | 0.58A | 3iltH-3anyB:undetectable | 3iltH-3anyB:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayq | LYSOZYME (Meretrixlusoria) |
PF05497(Destabilase) | 3 | ILE A 40SER A 61SER A 57 | NAG A 125 (-4.4A)NoneNone | 0.52A | 3iltH-3ayqA:undetectable | 3iltH-3ayqA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bnk | FLAVOREDOXIN (Methanosarcinaacetivorans) |
PF01613(Flavin_Reduct) | 3 | ILE A 138SER A 66SER A 68 | None | 0.50A | 3iltH-3bnkA:undetectable | 3iltH-3bnkA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | ILE A 757SER A 597SER A 762 | None | 0.51A | 3iltH-3c4fA:undetectable | 3iltH-3c4fA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdf | IMMUNOGLOBULIN LIGHTCHAIN (Homo sapiens) |
PF07686(V-set) | 3 | ILE A 83SER A 12SER A 14 | None | 0.56A | 3iltH-3cdfA:undetectable | 3iltH-3cdfA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e9m | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Enterococcusfaecalis) |
PF01408(GFO_IDH_MocA) | 3 | ILE A 248SER A 151SER A 235 | None | 0.63A | 3iltH-3e9mA:undetectable | 3iltH-3e9mA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eg4 | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-SUCCINYLTRANSFERASE (Brucella suis) |
PF00132(Hexapep)PF14602(Hexapep_2)PF14805(THDPS_N_2) | 3 | ILE A 171SER A 195SER A 166 | None | 0.58A | 3iltH-3eg4A:undetectable | 3iltH-3eg4A:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eh7 | 4-HYDROXYBUTYRATECOA-TRANSFERASE (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 3 | ILE A 357SER A 324SER A 329 | None | 0.61A | 3iltH-3eh7A:undetectable | 3iltH-3eh7A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gqk | PRENECK APPENDAGEPROTEIN (Bacillus virusphi29) |
PF11962(Peptidase_G2) | 3 | ILE A 787SER A 790SER A 743 | ATP A 1 (-3.6A)NoneNone | 0.65A | 3iltH-3gqkA:undetectable | 3iltH-3gqkA:22.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h6t | GLUTAMATE RECEPTOR 2 (Rattusnorvegicus) |
PF10613(Lig_chan-Glu_bd) | 3 | ILE A 92SER A 108SER A 217 | NoneCYZ A 265 (-2.8A)GOL A 270 ( 3.0A) | 0.42A | 3iltH-3h6tA:36.8 | 3iltH-3h6tA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ide | CAPSID PROTEIN VP2 (Infectiouspancreaticnecrosis virus) |
PF01766(Birna_VP2) | 3 | ILE A 64SER A 86SER A 40 | None | 0.58A | 3iltH-3ideA:undetectable | 3iltH-3ideA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksu | 3-OXOACYL-ACYLCARRIER PROTEINREDUCTASE (Oenococcus oeni) |
PF13561(adh_short_C2) | 3 | ILE A 128SER A 174SER A 183 | None | 0.60A | 3iltH-3ksuA:undetectable | 3iltH-3ksuA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntc | FAB LIGHT CHAIN (Homo sapiens;Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | ILE L 83SER L 12SER L 14 | None | 0.48A | 3iltH-3ntcL:undetectable | 3iltH-3ntcL:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oja | LEUCINE-RICH IMMUNEMOLECULE 1 (Anophelesgambiae) |
PF00560(LRR_1) | 3 | ILE A 123SER A 139SER A 137 | None | 0.61A | 3iltH-3ojaA:undetectable | 3iltH-3ojaA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pg8 | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Thermotogamaritima) |
PF00793(DAHP_synth_1) | 3 | ILE A 181SER A 199SER A 195 | NoneAZI A 6 (-2.8A)None | 0.61A | 3iltH-3pg8A:undetectable | 3iltH-3pg8A:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvz | UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE (Aliivibriofischeri) |
PF02719(Polysacc_synt_2) | 3 | ILE A 52SER A 33SER A 31 | None | 0.58A | 3iltH-3pvzA:undetectable | 3iltH-3pvzA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qt4 | CATHEPSIN-L-LIKEMIDGUT CYSTEINEPROTEINASE (Tenebriomolitor) |
PF00112(Peptidase_C1)PF08246(Inhibitor_I29) | 3 | ILE A 174SER A 154SER A 169 | None | 0.65A | 3iltH-3qt4A:undetectable | 3iltH-3qt4A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r7t | ADENYLOSUCCINATESYNTHETASE (Campylobacterjejuni) |
PF00709(Adenylsucc_synt) | 3 | ILE A 415SER A 324SER A 405 | None | 0.56A | 3iltH-3r7tA:undetectable | 3iltH-3r7tA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rb9 | DNA POLYMERASE IIISUBUNIT BETA (Mycobacteriumtuberculosis) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 3 | ILE A 171SER A 196SER A 194 | None | 0.54A | 3iltH-3rb9A:undetectable | 3iltH-3rb9A:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rhg | PUTATIVEPHOPHOTRIESTERASE (Proteusmirabilis) |
PF02126(PTE) | 3 | ILE A 105SER A 123SER A 98 | None | 0.56A | 3iltH-3rhgA:undetectable | 3iltH-3rhgA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tk8 | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-SUCCINYLTRANSFERASE (Burkholderiapseudomallei) |
PF00132(Hexapep)PF14602(Hexapep_2)PF14805(THDPS_N_2) | 3 | ILE A 203SER A 227SER A 198 | None | 0.64A | 3iltH-3tk8A:undetectable | 3iltH-3tk8A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | ILE A 757SER A 597SER A 762 | None | 0.50A | 3iltH-3tt0A:undetectable | 3iltH-3tt0A:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0a | NTNH (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 3 | ILE B 932SER B1007SER B 918 | None | 0.63A | 3iltH-3v0aB:undetectable | 3iltH-3v0aB:12.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0w | WN1 222-5 FAB(IGG2A) LIGHT CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | ILE L 83SER L 12SER L 14 | None | 0.53A | 3iltH-3v0wL:undetectable | 3iltH-3v0wL:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wqo | UNCHARACTERIZEDPROTEIN MJ1311 (Methanocaldococcusjannaschii) |
PF01261(AP_endonuc_2) | 3 | ILE A 264SER A 34SER A 23 | None | 0.49A | 3iltH-3wqoA:undetectable | 3iltH-3wqoA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5a | NUCLEOSIDE-TRIPHOSPHATASE 1 (Toxoplasmagondii) |
PF01150(GDA1_CD39) | 3 | ILE A 95SER A 62SER A 87 | None | 0.59A | 3iltH-4a5aA:undetectable | 3iltH-4a5aA:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4auo | INTERSTITIALCOLLAGENASE (Homo sapiens) |
PF00045(Hemopexin)PF00413(Peptidase_M10) | 3 | ILE A 234SER A 244SER A 123 | None | 0.61A | 3iltH-4auoA:undetectable | 3iltH-4auoA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aur | LEOA (Escherichiacoli) |
PF00350(Dynamin_N) | 3 | ILE A 314SER A 389SER A 393 | None | 0.65A | 3iltH-4aurA:undetectable | 3iltH-4aurA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8j | IMPORTIN SUBUNITALPHA-1A (Oryza sativa) |
PF00514(Arm)PF01749(IBB)PF16186(Arm_3) | 3 | ILE A 439SER A 394SER A 398 | None | 0.64A | 3iltH-4b8jA:undetectable | 3iltH-4b8jA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4by6 | GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 2 (Saccharomycescerevisiae) |
PF04153(NOT2_3_5) | 3 | ILE B 43SER B 40SER B 36 | None | 0.59A | 3iltH-4by6B:undetectable | 3iltH-4by6B:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dry | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Sinorhizobiummeliloti) |
PF00106(adh_short) | 3 | ILE A 39SER A 31SER A 36 | None | 0.57A | 3iltH-4dryA:undetectable | 3iltH-4dryA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gd5 | PHOSPHATE ABCTRANSPORTER,PHOSPHATE-BINDINGPROTEIN (Clostridiumperfringens) |
PF12849(PBP_like_2) | 3 | ILE A 75SER A 41SER A 159 | NonePO4 A 301 (-2.5A)PO4 A 301 (-2.7A) | 0.48A | 3iltH-4gd5A:12.0 | 3iltH-4gd5A:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4imd | N-ACETYLNEURAMINATELYASE (Pasteurellamultocida) |
PF00701(DHDPS) | 3 | ILE A 126SER A 102SER A 104 | None | 0.63A | 3iltH-4imdA:undetectable | 3iltH-4imdA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kq6 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE ([Candida]glabrata) |
PF00885(DMRL_synthase) | 3 | ILE A 110SER A 61SER A 103 | None | 0.57A | 3iltH-4kq6A:2.5 | 3iltH-4kq6A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ksi | LEUCINEAMINOPEPTIDASE 1,CHLOROPLASTIC (Solanumlycopersicum) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 3 | ILE A 241SER A 200SER A 196 | None | 0.55A | 3iltH-4ksiA:undetectable | 3iltH-4ksiA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mlz | PERIPLASMIC BINDINGPROTEIN (Jonesiadenitrificans) |
PF01497(Peripla_BP_2) | 3 | ILE A 198SER A 213SER A 209 | None | 0.63A | 3iltH-4mlzA:undetectable | 3iltH-4mlzA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nef | AQUAPORIN-2 (Homo sapiens) |
PF00230(MIP) | 3 | ILE A 52SER A 167SER A 163 | NoneNone CD A 301 ( 4.4A) | 0.57A | 3iltH-4nefA:undetectable | 3iltH-4nefA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nlb | RIBOSOMAL RNAPROCESSING PROTEIN 6 (Trypanosomabrucei) |
PF00570(HRDC)PF01612(DNA_pol_A_exo1) | 3 | ILE A 473SER A 499SER A 495 | None | 0.59A | 3iltH-4nlbA:undetectable | 3iltH-4nlbA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oe5 | DELTA-1-PYRROLINE-5-CARBOXYLATEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF00171(Aldedh) | 3 | ILE A 415SER A 454SER A 436 | None | 0.40A | 3iltH-4oe5A:undetectable | 3iltH-4oe5A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oj2 | AQUAPORIN-2 (Homo sapiens) |
PF00230(MIP) | 3 | ILE X 52SER X 167SER X 163 | None | 0.60A | 3iltH-4oj2X:undetectable | 3iltH-4oj2X:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oj5 | TAILSPIKE PROTEIN (Escherichiavirus CBA120) |
no annotation | 3 | ILE A 496SER A 471SER A 499 | None | 0.63A | 3iltH-4oj5A:undetectable | 3iltH-4oj5A:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p7y | METHIONINEGAMMA-LYASE (Citrobacterfreundii) |
PF01053(Cys_Met_Meta_PP) | 3 | ILE A 129SER A 123SER A 121 | None | 0.58A | 3iltH-4p7yA:undetectable | 3iltH-4p7yA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q8r | PHOSPHATE ABCTRANSPORTER,PHOSPHATE-BINDINGPROTEIN (Clostridiumperfringens) |
PF12849(PBP_like_2) | 3 | ILE A 45SER A 11SER A 129 | NonePO4 A 301 (-2.5A)PO4 A 301 (-2.6A) | 0.45A | 3iltH-4q8rA:12.1 | 3iltH-4q8rA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uph | SULFATASE (SULFURICESTER HYDROLASE)PROTEIN (Agrobacteriumtumefaciens) |
PF00884(Sulfatase)PF16347(DUF4976) | 3 | ILE A 290SER A 226SER A 181 | None | 0.49A | 3iltH-4uphA:undetectable | 3iltH-4uphA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w60 | LATE PROTEIN H7 (Vaccinia virus) |
PF04787(Pox_H7) | 3 | ILE A 93SER A 30SER A 98 | None | 0.60A | 3iltH-4w60A:undetectable | 3iltH-4w60A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x22 | TRIOSEPHOSPHATEISOMERASE (Leptospirainterrogans) |
PF00121(TIM) | 3 | ILE A 196SER A 209SER A 205 | None | 0.57A | 3iltH-4x22A:undetectable | 3iltH-4x22A:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zkt | BONTOXILYSIN A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 3 | ILE A 134SER A 140SER A 137 | None | 0.60A | 3iltH-4zktA:undetectable | 3iltH-4zktA:11.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | ILE A 757SER A 597SER A 762 | None | 0.63A | 3iltH-5a46A:undetectable | 3iltH-5a46A:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ah0 | LIPASE (Pelosinusfermentans) |
no annotation | 3 | ILE A 21SER A 396SER A 18 | None | 0.46A | 3iltH-5ah0A:undetectable | 3iltH-5ah0A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | PROBABLE TRANSLATIONINITIATION FACTOREIF-2B SUBUNITEPSILON (Schizosaccharomycespombe) |
PF00132(Hexapep)PF00483(NTP_transferase) | 3 | ILE I 327SER I 343SER I 324 | None | 0.64A | 3iltH-5b04I:undetectable | 3iltH-5b04I:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c5x | AQUAPORIN-5 (Homo sapiens) |
PF00230(MIP) | 3 | ILE A 53SER A 168SER A 164 | None | 0.51A | 3iltH-5c5xA:undetectable | 3iltH-5c5xA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5edj | FRPC OPERON PROTEIN (Neisseriameningitidis) |
PF06901(FrpC) | 3 | ILE A 239SER A 221SER A 223 | None | 0.53A | 3iltH-5edjA:undetectable | 3iltH-5edjA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f3y | UNCONVENTIONALMYOSIN-VIIB (Mus musculus) |
PF00784(MyTH4) | 3 | ILE A1262SER A1198SER A1218 | None | 0.55A | 3iltH-5f3yA:undetectable | 3iltH-5f3yA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fpn | HEAT SHOCK-RELATED70 KDA PROTEIN 2 (Homo sapiens) |
PF00012(HSP70) | 3 | ILE A 67SER A 120SER A 40 | None | 0.55A | 3iltH-5fpnA:undetectable | 3iltH-5fpnA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5inw | PUTATIVEANGIOTENSINOGEN (Lampetrafluviatilis) |
PF00079(Serpin) | 3 | ILE A 241SER A 177SER A 238 | None | 0.64A | 3iltH-5inwA:undetectable | 3iltH-5inwA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ja1 | ENTEROBACTINSYNTHASE COMPONENT F (Escherichiacoli) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 3 | ILE A 872SER A 604SER A 606 | None | 0.61A | 3iltH-5ja1A:undetectable | 3iltH-5ja1A:11.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jay | 8-AMINO-7-OXONONANOATE SYNTHASE (Paraburkholderiaxenovorans) |
PF00155(Aminotran_1_2) | 3 | ILE A 305SER A 369SER A 371 | None | 0.61A | 3iltH-5jayA:undetectable | 3iltH-5jayA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jqk | PEPTIDASE, PUTATIVE (Plasmodiumfalciparum) |
PF00557(Peptidase_M24)PF01321(Creatinase_N)PF16188(Peptidase_M24_C)PF16189(Creatinase_N_2) | 3 | ILE A 452SER A 445SER A 443 | None | 0.63A | 3iltH-5jqkA:undetectable | 3iltH-5jqkA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jyl | SCFV TSP7 (Mus musculus) |
PF07686(V-set) | 3 | ILE B 221SER B 150SER B 152 | None | 0.40A | 3iltH-5jylB:undetectable | 3iltH-5jylB:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jzg | CAPSID PROTEIN VP0 (Rhinovirus C) |
PF00073(Rhv)PF02226(Pico_P1A) | 3 | ILE C 270SER C 67SER C 69 | None | 0.61A | 3iltH-5jzgC:undetectable | 3iltH-5jzgC:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kay | SPELTER (unidentified) |
PF00669(Flagellin_N) | 3 | ILE A 86SER A 29SER A 25 | None | 0.61A | 3iltH-5kayA:undetectable | 3iltH-5kayA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kdj | F5/8 TYPE C DOMAINPROTEIN (Clostridiumperfringens) |
no annotation | 3 | ILE B1000SER B 943SER B 941 | None | 0.62A | 3iltH-5kdjB:undetectable | 3iltH-5kdjB:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kov | PL-2 SCFV CHAIN (Mus musculus) |
PF07686(V-set) | 3 | ILE C1083SER C1012SER C1014 | None | 0.50A | 3iltH-5kovC:undetectable | 3iltH-5kovC:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kwn | E3 UBIQUITIN-PROTEINLIGASE COP1 (Arabidopsisthaliana) |
PF00400(WD40) | 3 | ILE A 373SER A 424SER A 376 | None | 0.62A | 3iltH-5kwnA:undetectable | 3iltH-5kwnA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kwn | E3 UBIQUITIN-PROTEINLIGASE COP1 (Arabidopsisthaliana) |
PF00400(WD40) | 3 | ILE A 395SER A 376SER A 424 | None | 0.59A | 3iltH-5kwnA:undetectable | 3iltH-5kwnA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lkm | DNA REPAIR PROTEINRADA (Streptococcuspneumoniae) |
PF13481(AAA_25)PF13541(ChlI) | 3 | ILE A 168SER A 122SER A 171 | None | 0.47A | 3iltH-5lkmA:undetectable | 3iltH-5lkmA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ly9 | VARIANT SURFACEGLYCOPROTEIN MITAT1.1 (Trypanosomabrucei) |
PF00913(Trypan_glycop) | 3 | ILE A 105SER A 22SER A 148 | None | 0.63A | 3iltH-5ly9A:undetectable | 3iltH-5ly9A:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uz5 | U1 SMALL NUCLEARRIBONUCLEOPROTEINCOMPONENT PRP42 (Saccharomycescerevisiae) |
no annotation | 3 | ILE D 486SER D 491SER D 449 | None | 0.61A | 3iltH-5uz5D:undetectable | 3iltH-5uz5D:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wbl | REGULATORY-ASSOCIATED PROTEIN OF TOR 1 (Arabidopsisthaliana) |
no annotation | 3 | ILE A1275SER A1012SER A1010 | None | 0.55A | 3iltH-5wblA:undetectable | 3iltH-5wblA:14.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wel | CHIMERA OF GLUTAMATERECEPTOR 2, GERMCELL-SPECIFIC GENE1-LIKE PROTEIN (Mus musculus;Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF07803(GSG-1)PF10613(Lig_chan-Glu_bd) | 3 | ILE A 481SER A 497SER A 729 | None | 0.32A | 3iltH-5welA:28.5 | 3iltH-5welA:66.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5weo | GLUTAMATE RECEPTOR2,VOLTAGE-DEPENDENTCALCIUM CHANNELGAMMA-2 SUBUNITCHIMERA (Mus musculus;Rattusnorvegicus) |
PF00060(Lig_chan)PF00822(PMP22_Claudin)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 3 | ILE A 481SER A 497SER A 729 | NoneCYZ A1302 (-3.2A)None | 0.39A | 3iltH-5weoA:21.0 | 3iltH-5weoA:66.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wnn | PHOSPHATE-BINDINGPROTEIN PSTS (Burkholderiapseudomallei) |
PF12849(PBP_like_2) | 3 | ILE A 65SER A 75SER A 59 | None | 0.50A | 3iltH-5wnnA:5.0 | 3iltH-5wnnA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x04 | DODECANOYL-[ACYL-CARRIER-PROTEIN]HYDROLASE,CHLOROPLASTIC (Umbellulariacalifornica) |
no annotation | 3 | ILE A 189SER A 219SER A 217 | None | 0.64A | 3iltH-5x04A:undetectable | 3iltH-5x04A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xap | PROTEIN TRANSLOCASESUBUNIT SECD (Deinococcusradiodurans) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 3 | ILE A 694SER A 667SER A 671 | None | 0.64A | 3iltH-5xapA:undetectable | 3iltH-5xapA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | RIBOSOMAL PROTEINS3, PUTATIVE (Trichomonasvaginalis) |
PF00189(Ribosomal_S3_C)PF07650(KH_2) | 3 | ILE D 183SER D 151SER D 149 | None | 0.59A | 3iltH-5xyiD:undetectable | 3iltH-5xyiD:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6amz | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-SUCCINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00132(Hexapep)PF14602(Hexapep_2)PF14805(THDPS_N_2) | 3 | ILE A 164SER A 188SER A 159 | None | 0.64A | 3iltH-6amzA:undetectable | 3iltH-6amzA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ckt | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-SUCCINYLTRANSFERASE (Legionellapneumophila) |
no annotation | 3 | ILE A 164SER A 188SER A 159 | None | 0.62A | 3iltH-6cktA:undetectable | 3iltH-6cktA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6epe | PROTEASOME SUBUNITBETA TYPE-1 (Rattusnorvegicus) |
no annotation | 3 | ILE 6 115SER 6 161SER 6 150 | None | 0.46A | 3iltH-6epe6:undetectable | 3iltH-6epe6:17.02 |