SIMILAR PATTERNS OF AMINO ACIDS FOR 3IK6_B_HCZB262_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b5f | PROTEIN (CARDOSIN A) (Cynaracardunculus) |
PF00026(Asp) | 5 | ILE A 18SER A 88GLY A 19SER A 61LEU A 38 | None | 1.42A | 3ik6B-1b5fA:0.03ik6E-1b5fA:0.0 | 3ik6B-1b5fA:21.353ik6E-1b5fA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dab | P.69 PERTACTIN (Bordetellapertussis) |
PF03212(Pertactin) | 5 | ILE A 401SER A 421SER A 447GLY A 423LEU A 417 | None | 1.27A | 3ik6B-1dabA:0.03ik6E-1dabA:0.0 | 3ik6B-1dabA:17.263ik6E-1dabA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f0i | PHOSPHOLIPASE D (Streptomycessp. PMF) |
PF13091(PLDc_2) | 5 | ILE A 78SER A 109GLY A 79LEU A 174SER A 180 | None | 1.28A | 3ik6B-1f0iA:0.03ik6E-1f0iA:0.0 | 3ik6B-1f0iA:20.473ik6E-1f0iA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz6 | ESTRADIOL 17BETA-DEHYDROGENASE 4 (Rattusnorvegicus) |
PF00106(adh_short) | 5 | ILE A 155SER A 165LYS A 168GLY A 154LEU A 236 | NoneNoneNAI A1306 (-2.9A)NoneNone | 1.43A | 3ik6B-1gz6A:0.03ik6E-1gz6A:0.0 | 3ik6B-1gz6A:21.973ik6E-1gz6A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ldn | L-LACTATEDEHYDROGENASE (Geobacillusstearothermophilus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 190SER A 273GLY A 288LEU A 198SER A 317 | None | 1.20A | 3ik6B-1ldnA:0.03ik6E-1ldnA:0.0 | 3ik6B-1ldnA:20.923ik6E-1ldnA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lvl | DIHYDROLIPOAMIDEDEHYDROGENASE (Pseudomonasputida) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 188SER A 198GLY A 187LYS A 192LEU A 225 | None | 1.27A | 3ik6B-1lvlA:0.03ik6E-1lvlA:0.0 | 3ik6B-1lvlA:20.713ik6E-1lvlA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1olt | OXYGEN-INDEPENDENTCOPROPORPHYRINOGENIII OXIDASE (Escherichiacoli) |
PF04055(Radical_SAM)PF06969(HemN_C) | 5 | ILE A 423GLY A 422SER A 386LEU A 377SER A 376 | None | 1.25A | 3ik6B-1oltA:0.03ik6E-1oltA:0.0 | 3ik6B-1oltA:21.363ik6E-1oltA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdl | PROTEIN(ANTHRANILATESYNTHASE(TRPG-SUBUNIT)) (Sulfolobussolfataricus) |
PF00117(GATase) | 5 | ILE B 187PRO B 176LYS B 186GLY B 184LEU B 122 | None | 1.37A | 3ik6B-1qdlB:0.53ik6E-1qdlB:0.5 | 3ik6B-1qdlB:21.693ik6E-1qdlB:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qr4 | PROTEIN (TENASCIN) (Gallus gallus) |
PF00041(fn3) | 5 | ILE A 66SER A 85LYS A 83GLY A 84LEU A 6 | None | 1.24A | 3ik6B-1qr4A:0.03ik6E-1qr4A:0.0 | 3ik6B-1qr4A:22.693ik6E-1qr4A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rki | HYPOTHETICAL PROTEIN (Pyrobaculumaerophilum) |
PF11424(DUF3195) | 5 | ILE A 37SER A 40LYS A 41GLY A 38LYS A 35 | None | 1.29A | 3ik6B-1rkiA:undetectable3ik6E-1rkiA:undetectable | 3ik6B-1rkiA:18.033ik6E-1rkiA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sfj | 3-DEHYDROQUINATEDEHYDRATASE (Staphylococcusaureus) |
PF01487(DHquinase_I) | 5 | ILE A 226SER A 195GLY A 224SER A 193LEU A 231 | None | 1.35A | 3ik6B-1sfjA:undetectable3ik6E-1sfjA:undetectable | 3ik6B-1sfjA:23.553ik6E-1sfjA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1smr | RENIN (Mus musculus) |
PF00026(Asp) | 5 | ILE A 18SER A 88GLY A 19SER A 61LEU A 38 | None | 1.41A | 3ik6B-1smrA:undetectable3ik6E-1smrA:undetectable | 3ik6B-1smrA:20.003ik6E-1smrA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdw | TRYPTOPHAN SYNTHASEALPHA CHAIN (Pyrococcusfuriosus) |
PF00290(Trp_syntA) | 5 | ILE A 227PRO A 16LYS A 230GLY A 231LEU A 238 | None | 1.23A | 3ik6B-1wdwA:undetectable3ik6E-1wdwA:undetectable | 3ik6B-1wdwA:22.433ik6E-1wdwA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yrg | GTPASE-ACTIVATINGPROTEIN RNA1_SCHPO (Schizosaccharomycespombe) |
no annotation | 5 | ILE A 204PRO A 201GLY A 232SER A 257LEU A 223 | None | 1.30A | 3ik6B-1yrgA:undetectable3ik6E-1yrgA:undetectable | 3ik6B-1yrgA:21.263ik6E-1yrgA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e5v | L-ASPARTATE OXIDASE (Sulfurisphaeratokodaii) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | ILE A 121SER A 36GLY A 118SER A 353LEU A 125 | NoneFAD A1002 (-3.7A)NoneFAD A1002 (-2.6A)None | 1.38A | 3ik6B-2e5vA:undetectable3ik6E-2e5vA:undetectable | 3ik6B-2e5vA:20.673ik6E-2e5vA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6i | ATP-DEPENDENT CLPPROTEASE, PUTATIVE (Plasmodiumfalciparum) |
PF00574(CLP_protease) | 5 | ILE A 243SER A 236GLY A 240LEU A 199SER A 232 | None | 1.29A | 3ik6B-2f6iA:undetectable3ik6E-2f6iA:undetectable | 3ik6B-2f6iA:22.183ik6E-2f6iA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iou | PERTACTINEXTRACELLULAR DOMAIN (Bordetellabronchiseptica) |
PF03212(Pertactin) | 5 | ILE G 434SER G 454SER G 480GLY G 456LEU G 450 | None | 1.30A | 3ik6B-2iouG:undetectable3ik6E-2iouG:undetectable | 3ik6B-2iouG:15.913ik6E-2iouG:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jbh | PHOSPHORIBOSYLTRANSFERASEDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00156(Pribosyltran) | 5 | ILE A 64SER A 101GLY A 65SER A 93LEU A 138 | None | 1.42A | 3ik6B-2jbhA:undetectable3ik6E-2jbhA:undetectable | 3ik6B-2jbhA:22.813ik6E-2jbhA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ntb | PECTINESTERASE A (Dickeyadadantii) |
PF01095(Pectinesterase) | 5 | ILE A 117SER A 162SER A 183GLY A 163LEU A 157 | None | 1.24A | 3ik6B-2ntbA:undetectable3ik6E-2ntbA:undetectable | 3ik6B-2ntbA:22.663ik6E-2ntbA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pw9 | PUTATIVE FORMATEDEHYDROGENASEACCESSORY PROTEIN (Desulfotaleapsychrophila) |
PF02634(FdhD-NarQ) | 5 | ILE A 214PRO A 215GLY A 213LEU A 158SER A 190 | None | 1.34A | 3ik6B-2pw9A:undetectable3ik6E-2pw9A:undetectable | 3ik6B-2pw9A:21.833ik6E-2pw9A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyx | TRYPTOPHANHALOGENASE (Shewanellafrigidimarina) |
PF04820(Trp_halogenase) | 5 | ILE A 356PRO A 335SER A 245GLY A 336LEU A 407 | None | 1.19A | 3ik6B-2pyxA:undetectable3ik6E-2pyxA:undetectable | 3ik6B-2pyxA:19.883ik6E-2pyxA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyx | TRYPTOPHANHALOGENASE (Shewanellafrigidimarina) |
PF04820(Trp_halogenase) | 5 | ILE A 356PRO A 335SER A 245GLY A 336SER A 248 | None | 1.35A | 3ik6B-2pyxA:undetectable3ik6E-2pyxA:undetectable | 3ik6B-2pyxA:19.883ik6E-2pyxA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qua | EXTRACELLULAR LIPASE (Serratiamarcescens) |
no annotation | 5 | ILE A 136SER A 90LYS A 126GLY A 125LEU A 196 | None | 1.15A | 3ik6B-2quaA:undetectable3ik6E-2quaA:undetectable | 3ik6B-2quaA:17.913ik6E-2quaA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rfb | CYTOCHROME P450 (Picrophilustorridus) |
PF00067(p450) | 5 | ILE A 122PRO A 123SER A 165GLY A 121LEU A 157 | None | 1.38A | 3ik6B-2rfbA:undetectable3ik6E-2rfbA:undetectable | 3ik6B-2rfbA:22.783ik6E-2rfbA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vca | ALPHA-N-ACETYLGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C)PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 5 | ILE A 219LYS A 242GLY A 243SER A 251LEU A 196 | None | 1.30A | 3ik6B-2vcaA:undetectable3ik6E-2vcaA:undetectable | 3ik6B-2vcaA:14.403ik6E-2vcaA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vz9 | FATTY ACID SYNTHASE (Sus scrofa) |
PF00107(ADH_zinc_N)PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08242(Methyltransf_12)PF08659(KR)PF14765(PS-DH)PF16197(KAsynt_C_assoc) | 5 | ILE A1685SER A1675GLY A1676SER A1723LEU A1715 | NoneNAP A3001 (-3.5A)NoneNAP A3001 (-2.9A)None | 1.37A | 3ik6B-2vz9A:undetectable3ik6E-2vz9A:undetectable | 3ik6B-2vz9A:7.053ik6E-2vz9A:7.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wge | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 1 (Mycobacteriumtuberculosis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | SER A 341LYS A 340GLY A 344SER A 41LEU A 353 | None NA A1426 ( 4.9A)NoneNoneNone | 1.40A | 3ik6B-2wgeA:undetectable3ik6E-2wgeA:undetectable | 3ik6B-2wgeA:21.883ik6E-2wgeA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yqh | UDP-N-ACETYLGLUCOSAMINEPYROPHOSPHORYLASE (Candidaalbicans) |
PF01704(UDPGP) | 5 | ILE A 388GLY A 387SER A 371LEU A 390SER A 223 | None | 1.39A | 3ik6B-2yqhA:undetectable3ik6E-2yqhA:undetectable | 3ik6B-2yqhA:17.783ik6E-2yqhA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqp | PROBABLE SECDFPROTEIN-EXPORTMEMBRANE PROTEIN (Thermusthermophilus) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 5 | ILE A 285PRO A 682SER A 277GLY A 281LEU A 305 | None | 1.21A | 3ik6B-3aqpA:undetectable3ik6E-3aqpA:undetectable | 3ik6B-3aqpA:16.423ik6E-3aqpA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqp | PROBABLE SECDFPROTEIN-EXPORTMEMBRANE PROTEIN (Thermusthermophilus) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 5 | SER A 634GLY A 704SER A 711LEU A 680SER A 676 | None | 1.30A | 3ik6B-3aqpA:undetectable3ik6E-3aqpA:undetectable | 3ik6B-3aqpA:16.423ik6E-3aqpA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdi | POLYNUCLEOTIDEPHOSPHORYLASE (Escherichiacoli) |
PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 5 | ILE A 556SER A 465GLY A 486SER A 460LEU A 350 | None | 1.12A | 3ik6B-3cdiA:undetectable3ik6E-3cdiA:undetectable | 3ik6B-3cdiA:16.673ik6E-3cdiA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cux | MALATE SYNTHASE (Bacillusanthracis) |
PF01274(Malate_synthase) | 5 | ILE A 422SER A 450GLY A 421LYS A 480LEU A 484 | None | 1.41A | 3ik6B-3cuxA:undetectable3ik6E-3cuxA:undetectable | 3ik6B-3cuxA:18.713ik6E-3cuxA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfy | MUCONATECYCLOISOMERASE (Thermotogamaritima) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 37LYS A 44GLY A 45SER A 111SER A 41 | None | 1.11A | 3ik6B-3dfyA:undetectable3ik6E-3dfyA:undetectable | 3ik6B-3dfyA:25.583ik6E-3dfyA:25.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gqj | CELL INHIBITINGFACTOR (CIF) (Photorhabduslaumondii) |
PF16374(CIF) | 5 | ILE A 276SER A 235GLY A 154LEU A 278SER A 160 | None | 1.25A | 3ik6B-3gqjA:undetectable3ik6E-3gqjA:undetectable | 3ik6B-3gqjA:21.003ik6E-3gqjA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h3j | L-LACTATEDEHYDROGENASE 1 (Staphylococcusaureus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 176SER A 258GLY A 273LEU A 184SER A 302 | None | 1.36A | 3ik6B-3h3jA:undetectable3ik6E-3h3jA:undetectable | 3ik6B-3h3jA:22.353ik6E-3h3jA:22.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h6t | GLUTAMATE RECEPTOR 2 (Rattusnorvegicus) |
PF10613(Lig_chan-Glu_bd) | 6 | ILE A 92PRO A 105SER A 108SER A 217LYS A 218GLY A 219 | NoneCYZ A 265 (-3.9A)CYZ A 265 (-2.8A)GOL A 270 ( 3.0A)NoneNone | 0.34A | 3ik6B-3h6tA:43.43ik6E-3h6tA:43.5 | 3ik6B-3h6tA:100.003ik6E-3h6tA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8b | XYLULOSE KINASE (Bifidobacteriumadolescentis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ILE A 439SER A 291GLY A 433SER A 295LEU A 407 | None | 1.31A | 3ik6B-3i8bA:undetectable3ik6E-3i8bA:undetectable | 3ik6B-3i8bA:20.663ik6E-3i8bA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k5w | CARBOHYDRATE KINASE (Helicobacterpylori) |
PF01256(Carb_kinase)PF03853(YjeF_N) | 5 | ILE A 420SER A 252GLY A 418LEU A 424SER A 425 | None | 1.28A | 3ik6B-3k5wA:undetectable3ik6E-3k5wA:undetectable | 3ik6B-3k5wA:20.093ik6E-3k5wA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kba | PROGESTERONERECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ILE A 804PRO A 805SER A 767GLY A 764LEU A 883 | None | 1.40A | 3ik6B-3kbaA:undetectable3ik6E-3kbaA:undetectable | 3ik6B-3kbaA:22.263ik6E-3kbaA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kx6 | FRUCTOSE-BISPHOSPHATE ALDOLASE (Babesia bovis) |
PF00274(Glycolytic) | 5 | ILE A 70SER A 296LYS A 25GLY A 26LEU A 66 | None | 1.42A | 3ik6B-3kx6A:undetectable3ik6E-3kx6A:undetectable | 3ik6B-3kx6A:23.703ik6E-3kx6A:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lzd | DPH2 (Pyrococcushorikoshii) |
PF01866(Diphthamide_syn) | 5 | ILE A 178PRO A 201SER A 180GLY A 179LEU A 176 | None | 1.39A | 3ik6B-3lzdA:undetectable3ik6E-3lzdA:undetectable | 3ik6B-3lzdA:22.423ik6E-3lzdA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mos | TRANSKETOLASE (Homo sapiens) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ILE A 248SER A 43SER A 40GLY A 245LEU A 262 | NoneTPP A 700 ( 4.3A)TPP A 700 (-2.5A)NoneNone | 1.43A | 3ik6B-3mosA:undetectable3ik6E-3mosA:undetectable | 3ik6B-3mosA:20.363ik6E-3mosA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nd0 | SLL0855 PROTEIN (Synechocystissp. PCC 6803) |
PF00654(Voltage_CLC) | 5 | ILE A 293GLY A 291SER A 134LEU A 297SER A 298 | None | 1.32A | 3ik6B-3nd0A:undetectable3ik6E-3nd0A:undetectable | 3ik6B-3nd0A:17.203ik6E-3nd0A:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3njx | RHAMNOGALACTURONASEB (Aspergillusaculeatus) |
PF09284(RhgB_N)PF14683(CBM-like)PF14686(fn3_3) | 5 | ILE A 51SER A 57GLY A 54SER A 26LEU A 78 | None | 1.38A | 3ik6B-3njxA:undetectable3ik6E-3njxA:undetectable | 3ik6B-3njxA:16.933ik6E-3njxA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nnd | POSSIBLE SUBSTRATEBINDING PROTEIN OFABC TRANSPORTERSYSTEM (Rhodopseudomonaspalustris) |
no annotation | 5 | ILE B 147PRO B 249LYS B 149GLY B 148LYS B 212 | None | 0.82A | 3ik6B-3nndB:undetectable3ik6E-3nndB:undetectable | 3ik6B-3nndB:20.423ik6E-3nndB:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3orq | N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDESYNTHETASE (Staphylococcusaureus) |
PF02222(ATP-grasp)PF02826(2-Hacid_dh_C) | 5 | ILE A 337SER A 341LYS A 340GLY A 339LEU A 320 | NoneNonePOP A 377 (-2.9A)NoneNone | 1.13A | 3ik6B-3orqA:undetectable3ik6E-3orqA:undetectable | 3ik6B-3orqA:21.173ik6E-3orqA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pqd | L-LACTATEDEHYDROGENASE (Bacillussubtilis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 175SER A 258GLY A 273LEU A 183SER A 302 | None | 1.16A | 3ik6B-3pqdA:undetectable3ik6E-3pqdA:undetectable | 3ik6B-3pqdA:22.853ik6E-3pqdA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3py9 | PROTEIN KINASE (Staphylococcusaureus) |
PF03793(PASTA) | 5 | ILE A 13SER A 16LYS A 15GLY A 14LYS A 49 | None | 1.15A | 3ik6B-3py9A:undetectable3ik6E-3py9A:undetectable | 3ik6B-3py9A:25.083ik6E-3py9A:25.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qyf | CRISPR-ASSOCIATEDPROTEIN (Sulfolobussolfataricus) |
PF09651(Cas_APE2256) | 5 | ILE A 109SER A 96GLY A 106LEU A 113SER A 120 | None | 1.38A | 3ik6B-3qyfA:undetectable3ik6E-3qyfA:undetectable | 3ik6B-3qyfA:20.433ik6E-3qyfA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uaj | ENVELOPE PROTEIN (Dengue virus) |
no annotation | 5 | ILE B 61SER B 122GLY B 123SER B 64LEU B 218 | None | 0.97A | 3ik6B-3uajB:undetectable3ik6E-3uajB:undetectable | 3ik6B-3uajB:19.263ik6E-3uajB:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uf6 | LMO1369 PROTEIN (Listeriamonocytogenes) |
PF01515(PTA_PTB) | 5 | ILE A 208SER A 222GLY A 224SER A 199LEU A 204 | None | 1.11A | 3ik6B-3uf6A:undetectable3ik6E-3uf6A:undetectable | 3ik6B-3uf6A:21.223ik6E-3uf6A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vot | L-AMINO ACID LIGASE,BL00235 (Bacilluslicheniformis) |
PF13535(ATP-grasp_4) | 5 | ILE A 307SER A 304LYS A 302GLY A 306LEU A 312 | None | 1.36A | 3ik6B-3votA:undetectable3ik6E-3votA:undetectable | 3ik6B-3votA:20.413ik6E-3votA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vot | L-AMINO ACID LIGASE,BL00235 (Bacilluslicheniformis) |
PF13535(ATP-grasp_4) | 5 | SER A 304LYS A 302GLY A 306SER A 221LEU A 312 | None | 1.15A | 3ik6B-3votA:undetectable3ik6E-3votA:undetectable | 3ik6B-3votA:20.413ik6E-3votA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vxi | DYP (Bjerkanderaadusta) |
PF04261(Dyp_perox) | 5 | ILE A 11GLY A 13SER A 330LEU A 198SER A 216 | None | 1.23A | 3ik6B-3vxiA:undetectable3ik6E-3vxiA:undetectable | 3ik6B-3vxiA:19.733ik6E-3vxiA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2q | RETINOIC ACIDINDUCIBLE PROTEIN I (Anasplatyrhynchos) |
PF00270(DEAD)PF00271(Helicase_C)PF16739(CARD_2) | 5 | ILE A 137PRO A 118LYS A 152GLY A 149LEU A 129 | None | 1.41A | 3ik6B-4a2qA:undetectable3ik6E-4a2qA:undetectable | 3ik6B-4a2qA:15.653ik6E-4a2qA:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4am6 | ACTIN-LIKE PROTEINARP8 (Saccharomycescerevisiae) |
PF00022(Actin) | 5 | ILE A 278PRO A 273GLY A 274SER A 407LEU A 428 | NoneNoneSO4 A1882 (-3.1A)NoneNone | 1.21A | 3ik6B-4am6A:undetectable3ik6E-4am6A:undetectable | 3ik6B-4am6A:17.253ik6E-4am6A:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4asl | EPA1P ([Candida]glabrata) |
PF10528(GLEYA) | 5 | ILE A 219SER A 254SER A 62GLY A 147LEU A 221 | None | 1.18A | 3ik6B-4aslA:undetectable3ik6E-4aslA:undetectable | 3ik6B-4aslA:22.803ik6E-4aslA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4boo | ACETYLCHOLINERECEPTOR BETASUBUNITACETYLCHOLINERECEPTOR DELTASUBUNITACETYLCHOLINERECEPTOR SUBUNITALPHA (Torpedomarmorata) |
PF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 5 | ILE A 247SER B 250SER B 254SER C 258LEU A 251 | None | 1.44A | 3ik6B-4booA:undetectable3ik6E-4booA:undetectable | 3ik6B-4booA:19.313ik6E-4booA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgn | GLYCYLPEPTIDEN-TETRADECANOYLTRANSFERASE (Leishmaniamajor) |
PF01233(NMT)PF02799(NMT_C) | 5 | ILE A 235PRO A 236SER A 233GLY A 234SER A 221 | None | 1.44A | 3ik6B-4cgnA:undetectable3ik6E-4cgnA:undetectable | 3ik6B-4cgnA:20.403ik6E-4cgnA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gx8 | DNA POLYMERASE IIISUBUNIT EPSILON,DNAPOLYMERASE IIISUBUNIT ALPHA (Escherichiacoli) |
PF02811(PHP) | 5 | ILE A 107PRO A 109GLY A 102LEU A 33SER A 31 | None | 1.31A | 3ik6B-4gx8A:undetectable3ik6E-4gx8A:undetectable | 3ik6B-4gx8A:21.983ik6E-4gx8A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4il5 | CYSTEINE SYNTHASE (Entamoebahistolytica) |
PF00291(PALP) | 5 | ILE A 285SER A 280GLY A 282SER A 308LEU A 29 | NoneLLP A 58 ( 2.5A)NoneLLP A 58 ( 3.3A)None | 1.38A | 3ik6B-4il5A:undetectable3ik6E-4il5A:undetectable | 3ik6B-4il5A:22.813ik6E-4il5A:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4itc | LYS-GINGIPAIN W83 (Porphyromonasgingivalis) |
PF07675(Cleaved_Adhesin) | 5 | ILE A 993PRO A 994SER A 988GLY A 992LEU A1045 | GAI A1206 (-4.0A)GOL A1207 ( 4.9A)NoneNoneNone | 1.38A | 3ik6B-4itcA:undetectable3ik6E-4itcA:undetectable | 3ik6B-4itcA:21.173ik6E-4itcA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k3c | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMA ([Haemophilus]ducreyi) |
PF01103(Bac_surface_Ag)PF07244(POTRA) | 5 | ILE A 782PRO A 773GLY A 661LYS A 776SER A 666 | None | 1.09A | 3ik6B-4k3cA:undetectable3ik6E-4k3cA:undetectable | 3ik6B-4k3cA:20.243ik6E-4k3cA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kcd | GLUTAMATE RECEPTORIONOTROPIC, NMDA 3A (Rattusnorvegicus) |
PF10613(Lig_chan-Glu_bd) | 5 | ILE A 126PRO A 139SER A 142SER A 144GLY A 251 | None | 1.29A | 3ik6B-4kcdA:29.73ik6E-4kcdA:29.7 | 3ik6B-4kcdA:29.703ik6E-4kcdA:29.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ln1 | L-LACTATEDEHYDROGENASE 1 (Bacillus cereus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 175SER A 258GLY A 273LEU A 183SER A 302 | None | 1.20A | 3ik6B-4ln1A:undetectable3ik6E-4ln1A:undetectable | 3ik6B-4ln1A:23.843ik6E-4ln1A:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mhc | NUCLEOPORIN NUP157 (Saccharomycescerevisiae) |
PF08801(Nucleoporin_N) | 5 | ILE A 506PRO A 543GLY A 505LEU A 599SER A 576 | None | 1.22A | 3ik6B-4mhcA:undetectable3ik6E-4mhcA:undetectable | 3ik6B-4mhcA:15.743ik6E-4mhcA:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1e | DIHYDROPTEROATESYNTHASE DHPS (Desulfitobacteriumhafniense) |
PF00809(Pterin_bind) | 5 | ILE A 130PRO A 131SER A 128GLY A 129SER A 100 | None | 1.11A | 3ik6B-4o1eA:undetectable3ik6E-4o1eA:undetectable | 3ik6B-4o1eA:21.363ik6E-4o1eA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rxt | SUGAR ABCTRANSPORTER (Agrobacteriumtumefaciens) |
PF13407(Peripla_BP_4) | 5 | ILE A 213GLY A 210LYS A 201SER A 230LEU A 217 | None | 1.42A | 3ik6B-4rxtA:3.53ik6E-4rxtA:3.3 | 3ik6B-4rxtA:25.393ik6E-4rxtA:25.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4sli | INTRAMOLECULARTRANS-SIALIDASE (Macrobdelladecora) |
PF02973(Sialidase)PF13088(BNR_2) | 5 | ILE A 398SER A 370SER A 321LYS A 320GLY A 397 | None | 1.27A | 3ik6B-4sliA:undetectable3ik6E-4sliA:undetectable | 3ik6B-4sliA:17.603ik6E-4sliA:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhb | SIALIDASE B (Streptococcuspneumoniae) |
PF02012(BNR)PF02973(Sialidase)PF13088(BNR_2) | 5 | ILE A 350SER A 322SER A 273LYS A 272GLY A 349 | None | 1.29A | 3ik6B-4xhbA:undetectable3ik6E-4xhbA:undetectable | 3ik6B-4xhbA:17.423ik6E-4xhbA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9v | PARTICLE-ASSOCIATEDLYASE (Acinetobactervirus AP22) |
no annotation | 5 | ILE A 724PRO A 656SER A 722GLY A 723LYS A 654 | None | 1.31A | 3ik6B-4y9vA:undetectable3ik6E-4y9vA:undetectable | 3ik6B-4y9vA:16.013ik6E-4y9vA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a22 | VESICULAR STOMATITISVIRUS L POLYMERASE (Vesicularstomatitisvirus) |
PF00946(Mononeg_RNA_pol)PF14314(Methyltrans_Mon)PF14318(Mononeg_mRNAcap) | 5 | ILE A 884PRO A 933SER A 952GLY A 885SER A1093 | None | 1.33A | 3ik6B-5a22A:undetectable3ik6E-5a22A:undetectable | 3ik6B-5a22A:8.173ik6E-5a22A:8.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bob | TRANSLATIONINITIATION FACTOR 2(IF-2 GTPASE) (Streptococcussuis) |
no annotation | 5 | ILE A 287SER A 317SER A 189GLY A 195LEU A 293 | None | 1.40A | 3ik6B-5bobA:undetectable3ik6E-5bobA:undetectable | 3ik6B-5bobA:21.303ik6E-5bobA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bs5 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | ILE A 488SER A 414GLY A 487LEU A 477SER A 481 | None | 1.26A | 3ik6B-5bs5A:undetectable3ik6E-5bs5A:undetectable | 3ik6B-5bs5A:22.193ik6E-5bs5A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cef | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Cryptococcusneoformans) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | ILE A 23SER A 87GLY A 19SER A 351LEU A 34 | None | 1.39A | 3ik6B-5cefA:undetectable3ik6E-5cefA:undetectable | 3ik6B-5cefA:21.323ik6E-5cefA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ghf | AMINOTRANSFERASECLASS-III (Ochrobactrumanthropi) |
PF00202(Aminotran_3) | 5 | ILE A 430PRO A 428GLY A 63SER A 59LEU A 347 | None | 1.26A | 3ik6B-5ghfA:undetectable3ik6E-5ghfA:undetectable | 3ik6B-5ghfA:19.213ik6E-5ghfA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijb | TOLL-LIKE RECEPTOR4, VARIABLELYMPHOCYTE RECEPTORB CHIMERA (Eptatretusburgeri;Mus musculus) |
PF00560(LRR_1)PF11921(DUF3439)PF13855(LRR_8) | 5 | ILE A 145PRO A 144SER A 142SER A 115LEU A 130 | None | 1.30A | 3ik6B-5ijbA:undetectable3ik6E-5ijbA:undetectable | 3ik6B-5ijbA:18.293ik6E-5ijbA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5irp | ALANINE RACEMASE 2 (Bacillussubtilis) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | ILE A 289SER A 296GLY A 290SER A 300LEU A 253 | None | 1.29A | 3ik6B-5irpA:undetectable3ik6E-5irpA:undetectable | 3ik6B-5irpA:21.643ik6E-5irpA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kc8 | GLUTAMATE RECEPTORIONOTROPIC, DELTA-2 (Homo sapiens) |
PF01094(ANF_receptor) | 5 | ILE A 90SER A 352GLY A 89SER A 354LEU A 93 | None | 1.24A | 3ik6B-5kc8A:undetectable3ik6E-5kc8A:undetectable | 3ik6B-5kc8A:19.633ik6E-5kc8A:19.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l1b | GLUTAMATE RECEPTOR2,GLUTAMATE RECEPTOR2 (Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | ILE A 481PRO A 494SER A 497LYS A 730GLY A 731 | None | 0.62A | 3ik6B-5l1bA:22.43ik6E-5l1bA:22.6 | 3ik6B-5l1bA:70.443ik6E-5l1bA:70.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2e | GLUTAMATE RECEPTORIONOTROPIC,DELTA-2,GLUTAMATERECEPTOR IONOTROPIC,DELTA-2 (Rattusnorvegicus) |
PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | ILE A 90SER A 352GLY A 89SER A 354LEU A 93 | None | 1.23A | 3ik6B-5l2eA:27.83ik6E-5l2eA:27.9 | 3ik6B-5l2eA:16.593ik6E-5l2eA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lvc | VP1 (Aichivirus A) |
no annotation | 5 | ILE a 89PRO a 54GLY a 88LEU a 93SER a 94 | None | 0.95A | 3ik6B-5lvca:undetectable3ik6E-5lvca:undetectable | 3ik6B-5lvca:22.393ik6E-5lvca:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mhf | MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE (Mus musculus) |
no annotation | 5 | ILE A 399SER A 393GLY A 398SER A 824LEU A 463 | None | 1.43A | 3ik6B-5mhfA:undetectable3ik6E-5mhfA:undetectable | 3ik6B-5mhfA:15.603ik6E-5mhfA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n72 | WIPA (Legionellapneumophila) |
no annotation | 5 | ILE A 218SER A 243SER A 187LEU A 210SER A 211 | NoneACT A 504 (-2.6A)ACT A 504 (-4.0A)NoneNone | 1.41A | 3ik6B-5n72A:undetectable3ik6E-5n72A:undetectable | 3ik6B-5n72A:20.053ik6E-5n72A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n8n | EVPB FAMILY TYPE VISECRETION PROTEIN (Pseudomonasaeruginosa) |
no annotation | 5 | ILE B 194SER B 369SER B 237GLY B 241SER B 186 | None | 1.16A | 3ik6B-5n8nB:undetectable3ik6E-5n8nB:undetectable | 3ik6B-5n8nB:14.403ik6E-5n8nB:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfg | PROCARDOSIN-B,PROCARDOSIN-B (Cynaracardunculus) |
no annotation | 5 | ILE A 66SER A 137GLY A 67SER A 110LEU A 86 | None | 1.41A | 3ik6B-5nfgA:undetectable3ik6E-5nfgA:undetectable | 3ik6B-5nfgA:20.413ik6E-5nfgA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oev | GLUTATHIONESYNTHETASE-LIKEEFFECTOR 22(GPA-GSS22-APO) (Globoderapallida) |
no annotation | 5 | ILE A 127SER A 458GLY A 441SER A 192LEU A 125 | None | 1.41A | 3ik6B-5oevA:undetectable3ik6E-5oevA:undetectable | 3ik6B-5oevA:17.053ik6E-5oevA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u25 | DIHYDROLIPOAMIDEDEHYDROGENASE (E3COMPONENT OFPYRUVATE AND2-OXOGLUTARATEDEHYDROGENASECOMPLEXES) (Neisseriagonorrhoeae) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 301SER A 286GLY A 308SER A 164LEU A 299 | NoneFAD A 601 ( 3.8A)NoneFAD A 601 ( 3.9A)None | 1.32A | 3ik6B-5u25A:undetectable3ik6E-5u25A:undetectable | 3ik6B-5u25A:18.963ik6E-5u25A:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj1 | DNA TOPOISOMERASE 1 (Mycobacteriumtuberculosis) |
no annotation | 5 | ILE A 141GLY A 338LYS A 28LEU A 32SER A 34 | None | 0.96A | 3ik6B-5uj1A:undetectable3ik6E-5uj1A:undetectable | 3ik6B-5uj1A:14.923ik6E-5uj1A:14.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wel | CHIMERA OF GLUTAMATERECEPTOR 2, GERMCELL-SPECIFIC GENE1-LIKE PROTEIN (Mus musculus;Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF07803(GSG-1)PF10613(Lig_chan-Glu_bd) | 6 | ILE A 481PRO A 494SER A 497SER A 729LYS A 730GLY A 731 | None | 0.73A | 3ik6B-5welA:32.53ik6E-5welA:32.9 | 3ik6B-5welA:66.933ik6E-5welA:66.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5weo | GLUTAMATE RECEPTOR2,VOLTAGE-DEPENDENTCALCIUM CHANNELGAMMA-2 SUBUNITCHIMERA (Mus musculus;Rattusnorvegicus) |
PF00060(Lig_chan)PF00822(PMP22_Claudin)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 6 | ILE A 481PRO A 494SER A 497SER A 729LYS A 730GLY A 731 | NoneCYZ A1302 (-4.5A)CYZ A1302 (-3.2A)NoneGLU A1301 ( 3.7A)None | 0.60A | 3ik6B-5weoA:25.33ik6E-5weoA:25.2 | 3ik6B-5weoA:66.933ik6E-5weoA:66.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wue | UNCHARACTERIZEDPROTEIN (Sulfolobusacidocaldarius) |
PF03458(UPF0126) | 5 | ILE A 138GLY A 136SER A 23LEU A 142SER A 143 | None | 0.99A | 3ik6B-5wueA:undetectable3ik6E-5wueA:undetectable | 3ik6B-5wueA:21.623ik6E-5wueA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x5y | PROBABLE ATP-BINDINGCOMPONENT OF ABCTRANSPORTER (Pseudomonasaeruginosa) |
no annotation | 5 | ILE B 80LYS B 157GLY B 79LEU B 4SER B 28 | None | 1.35A | 3ik6B-5x5yB:undetectable3ik6E-5x5yB:undetectable | 3ik6B-5x5yB:22.303ik6E-5x5yB:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtd | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN1 (Homo sapiens) |
PF15879(MWFE) | 5 | ILE s 105PRO s 88GLY s 101SER s 163LEU s 237 | None | 1.19A | 3ik6B-5xtds:undetectable3ik6E-5xtds:undetectable | 3ik6B-5xtds:20.863ik6E-5xtds:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bxe | VARIABLE LYMPHOCYTERECEPTOR DIVERSITYREGION (Petromyzonmarinus) |
no annotation | 5 | ILE A 47PRO A 23SER A 42GLY A 45LEU A 54 | None | 1.32A | 3ik6B-6bxeA:undetectable3ik6E-6bxeA:undetectable | 3ik6B-6bxeA:14.403ik6E-6bxeA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c0d | AMIDASE,HYDANTOINASE/CARBAMOYLASE FAMILY (Paraburkholderiaphymatum) |
no annotation | 5 | ILE A 78PRO A 187SER A 80GLY A 79LEU A 76 | NoneNone ZN A 501 ( 4.8A)NoneNone | 1.35A | 3ik6B-6c0dA:undetectable3ik6E-6c0dA:undetectable | 3ik6B-6c0dA:13.773ik6E-6c0dA:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfd | ATP-DEPENDENT CLPPROTEASE PROTEOLYTICSUBUNIT (Enterococcusfaecium) |
no annotation | 5 | ILE A 77SER A 70GLY A 74LEU A 32SER A 66 | None | 1.35A | 3ik6B-6cfdA:undetectable3ik6E-6cfdA:undetectable | 3ik6B-6cfdA:15.293ik6E-6cfdA:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cmz | DIHYDROLIPOYLDEHYDROGENASE (Burkholderiacenocepacia) |
no annotation | 5 | ILE A 192SER A 202GLY A 191LYS A 196LEU A 229 | None | 1.20A | 3ik6B-6cmzA:undetectable3ik6E-6cmzA:undetectable | 3ik6B-6cmzA:18.553ik6E-6cmzA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d04 | RETICULOCYTE BINDINGPROTEIN 2, PUTATIVE (Plasmodiumvivax) |
no annotation | 5 | ILE E 567PRO E 568LYS E 576LEU E 580SER E 582 | None | 1.16A | 3ik6B-6d04E:undetectable3ik6E-6d04E:undetectable | 3ik6B-6d04E:22.353ik6E-6d04E:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fnw | VOLUME-REGULATEDANION CHANNELSUBUNIT LRRC8A (Mus musculus) |
no annotation | 5 | ILE A 438PRO A 439SER A 436GLY A 437LEU A 451 | NoneNoneEDO A 904 (-2.9A)EDO A 904 ( 3.4A)None | 1.43A | 3ik6B-6fnwA:undetectable3ik6E-6fnwA:undetectable | 3ik6B-6fnwA:15.893ik6E-6fnwA:15.89 |