SIMILAR PATTERNS OF AMINO ACIDS FOR 3IK6_B_HCZB262_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus)
PF00026
(Asp)
5 ILE A  18
SER A  88
GLY A  19
SER A  61
LEU A  38
None
1.42A 3ik6B-1b5fA:
0.0
3ik6E-1b5fA:
0.0
3ik6B-1b5fA:
21.35
3ik6E-1b5fA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis)
PF03212
(Pertactin)
5 ILE A 401
SER A 421
SER A 447
GLY A 423
LEU A 417
None
1.27A 3ik6B-1dabA:
0.0
3ik6E-1dabA:
0.0
3ik6B-1dabA:
17.26
3ik6E-1dabA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF)
PF13091
(PLDc_2)
5 ILE A  78
SER A 109
GLY A  79
LEU A 174
SER A 180
None
1.28A 3ik6B-1f0iA:
0.0
3ik6E-1f0iA:
0.0
3ik6B-1f0iA:
20.47
3ik6E-1f0iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4


(Rattus
norvegicus)
PF00106
(adh_short)
5 ILE A 155
SER A 165
LYS A 168
GLY A 154
LEU A 236
None
None
NAI  A1306 (-2.9A)
None
None
1.43A 3ik6B-1gz6A:
0.0
3ik6E-1gz6A:
0.0
3ik6B-1gz6A:
21.97
3ik6E-1gz6A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 190
SER A 273
GLY A 288
LEU A 198
SER A 317
None
1.20A 3ik6B-1ldnA:
0.0
3ik6E-1ldnA:
0.0
3ik6B-1ldnA:
20.92
3ik6E-1ldnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE


(Pseudomonas
putida)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A 188
SER A 198
GLY A 187
LYS A 192
LEU A 225
None
1.27A 3ik6B-1lvlA:
0.0
3ik6E-1lvlA:
0.0
3ik6B-1lvlA:
20.71
3ik6E-1lvlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE


(Escherichia
coli)
PF04055
(Radical_SAM)
PF06969
(HemN_C)
5 ILE A 423
GLY A 422
SER A 386
LEU A 377
SER A 376
None
1.25A 3ik6B-1oltA:
0.0
3ik6E-1oltA:
0.0
3ik6B-1oltA:
21.36
3ik6E-1oltA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))


(Sulfolobus
solfataricus)
PF00117
(GATase)
5 ILE B 187
PRO B 176
LYS B 186
GLY B 184
LEU B 122
None
1.37A 3ik6B-1qdlB:
0.5
3ik6E-1qdlB:
0.5
3ik6B-1qdlB:
21.69
3ik6E-1qdlB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr4 PROTEIN (TENASCIN)

(Gallus gallus)
PF00041
(fn3)
5 ILE A  66
SER A  85
LYS A  83
GLY A  84
LEU A   6
None
1.24A 3ik6B-1qr4A:
0.0
3ik6E-1qr4A:
0.0
3ik6B-1qr4A:
22.69
3ik6E-1qr4A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rki HYPOTHETICAL PROTEIN

(Pyrobaculum
aerophilum)
PF11424
(DUF3195)
5 ILE A  37
SER A  40
LYS A  41
GLY A  38
LYS A  35
None
1.29A 3ik6B-1rkiA:
undetectable
3ik6E-1rkiA:
undetectable
3ik6B-1rkiA:
18.03
3ik6E-1rkiA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE


(Staphylococcus
aureus)
PF01487
(DHquinase_I)
5 ILE A 226
SER A 195
GLY A 224
SER A 193
LEU A 231
None
1.35A 3ik6B-1sfjA:
undetectable
3ik6E-1sfjA:
undetectable
3ik6B-1sfjA:
23.55
3ik6E-1sfjA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus)
PF00026
(Asp)
5 ILE A  18
SER A  88
GLY A  19
SER A  61
LEU A  38
None
1.41A 3ik6B-1smrA:
undetectable
3ik6E-1smrA:
undetectable
3ik6B-1smrA:
20.00
3ik6E-1smrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Pyrococcus
furiosus)
PF00290
(Trp_syntA)
5 ILE A 227
PRO A  16
LYS A 230
GLY A 231
LEU A 238
None
1.23A 3ik6B-1wdwA:
undetectable
3ik6E-1wdwA:
undetectable
3ik6B-1wdwA:
22.43
3ik6E-1wdwA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO


(Schizosaccharomyces
pombe)
no annotation 5 ILE A 204
PRO A 201
GLY A 232
SER A 257
LEU A 223
None
1.30A 3ik6B-1yrgA:
undetectable
3ik6E-1yrgA:
undetectable
3ik6B-1yrgA:
21.26
3ik6E-1yrgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 ILE A 121
SER A  36
GLY A 118
SER A 353
LEU A 125
None
FAD  A1002 (-3.7A)
None
FAD  A1002 (-2.6A)
None
1.38A 3ik6B-2e5vA:
undetectable
3ik6E-2e5vA:
undetectable
3ik6B-2e5vA:
20.67
3ik6E-2e5vA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE


(Plasmodium
falciparum)
PF00574
(CLP_protease)
5 ILE A 243
SER A 236
GLY A 240
LEU A 199
SER A 232
None
1.29A 3ik6B-2f6iA:
undetectable
3ik6E-2f6iA:
undetectable
3ik6B-2f6iA:
22.18
3ik6E-2f6iA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN


(Bordetella
bronchiseptica)
PF03212
(Pertactin)
5 ILE G 434
SER G 454
SER G 480
GLY G 456
LEU G 450
None
1.30A 3ik6B-2iouG:
undetectable
3ik6E-2iouG:
undetectable
3ik6B-2iouG:
15.91
3ik6E-2iouG:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00156
(Pribosyltran)
5 ILE A  64
SER A 101
GLY A  65
SER A  93
LEU A 138
None
1.42A 3ik6B-2jbhA:
undetectable
3ik6E-2jbhA:
undetectable
3ik6B-2jbhA:
22.81
3ik6E-2jbhA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii)
PF01095
(Pectinesterase)
5 ILE A 117
SER A 162
SER A 183
GLY A 163
LEU A 157
None
1.24A 3ik6B-2ntbA:
undetectable
3ik6E-2ntbA:
undetectable
3ik6B-2ntbA:
22.66
3ik6E-2ntbA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN


(Desulfotalea
psychrophila)
PF02634
(FdhD-NarQ)
5 ILE A 214
PRO A 215
GLY A 213
LEU A 158
SER A 190
None
1.34A 3ik6B-2pw9A:
undetectable
3ik6E-2pw9A:
undetectable
3ik6B-2pw9A:
21.83
3ik6E-2pw9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE


(Shewanella
frigidimarina)
PF04820
(Trp_halogenase)
5 ILE A 356
PRO A 335
SER A 245
GLY A 336
LEU A 407
None
1.19A 3ik6B-2pyxA:
undetectable
3ik6E-2pyxA:
undetectable
3ik6B-2pyxA:
19.88
3ik6E-2pyxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE


(Shewanella
frigidimarina)
PF04820
(Trp_halogenase)
5 ILE A 356
PRO A 335
SER A 245
GLY A 336
SER A 248
None
1.35A 3ik6B-2pyxA:
undetectable
3ik6E-2pyxA:
undetectable
3ik6B-2pyxA:
19.88
3ik6E-2pyxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens)
no annotation 5 ILE A 136
SER A  90
LYS A 126
GLY A 125
LEU A 196
None
1.15A 3ik6B-2quaA:
undetectable
3ik6E-2quaA:
undetectable
3ik6B-2quaA:
17.91
3ik6E-2quaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus)
PF00067
(p450)
5 ILE A 122
PRO A 123
SER A 165
GLY A 121
LEU A 157
None
1.38A 3ik6B-2rfbA:
undetectable
3ik6E-2rfbA:
undetectable
3ik6B-2rfbA:
22.78
3ik6E-2rfbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE


(Clostridium
perfringens)
PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C)
5 ILE A 219
LYS A 242
GLY A 243
SER A 251
LEU A 196
None
1.30A 3ik6B-2vcaA:
undetectable
3ik6E-2vcaA:
undetectable
3ik6B-2vcaA:
14.40
3ik6E-2vcaA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
5 ILE A1685
SER A1675
GLY A1676
SER A1723
LEU A1715
None
NAP  A3001 (-3.5A)
None
NAP  A3001 (-2.9A)
None
1.37A 3ik6B-2vz9A:
undetectable
3ik6E-2vz9A:
undetectable
3ik6B-2vz9A:
7.05
3ik6E-2vz9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 SER A 341
LYS A 340
GLY A 344
SER A  41
LEU A 353
None
NA  A1426 ( 4.9A)
None
None
None
1.40A 3ik6B-2wgeA:
undetectable
3ik6E-2wgeA:
undetectable
3ik6B-2wgeA:
21.88
3ik6E-2wgeA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE


(Candida
albicans)
PF01704
(UDPGP)
5 ILE A 388
GLY A 387
SER A 371
LEU A 390
SER A 223
None
1.39A 3ik6B-2yqhA:
undetectable
3ik6E-2yqhA:
undetectable
3ik6B-2yqhA:
17.78
3ik6E-2yqhA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN


(Thermus
thermophilus)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
5 ILE A 285
PRO A 682
SER A 277
GLY A 281
LEU A 305
None
1.21A 3ik6B-3aqpA:
undetectable
3ik6E-3aqpA:
undetectable
3ik6B-3aqpA:
16.42
3ik6E-3aqpA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN


(Thermus
thermophilus)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
5 SER A 634
GLY A 704
SER A 711
LEU A 680
SER A 676
None
1.30A 3ik6B-3aqpA:
undetectable
3ik6E-3aqpA:
undetectable
3ik6B-3aqpA:
16.42
3ik6E-3aqpA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE


(Escherichia
coli)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
5 ILE A 556
SER A 465
GLY A 486
SER A 460
LEU A 350
None
1.12A 3ik6B-3cdiA:
undetectable
3ik6E-3cdiA:
undetectable
3ik6B-3cdiA:
16.67
3ik6E-3cdiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis)
PF01274
(Malate_synthase)
5 ILE A 422
SER A 450
GLY A 421
LYS A 480
LEU A 484
None
1.41A 3ik6B-3cuxA:
undetectable
3ik6E-3cuxA:
undetectable
3ik6B-3cuxA:
18.71
3ik6E-3cuxA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfy MUCONATE
CYCLOISOMERASE


(Thermotoga
maritima)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A  37
LYS A  44
GLY A  45
SER A 111
SER A  41
None
1.11A 3ik6B-3dfyA:
undetectable
3ik6E-3dfyA:
undetectable
3ik6B-3dfyA:
25.58
3ik6E-3dfyA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqj CELL INHIBITING
FACTOR (CIF)


(Photorhabdus
laumondii)
PF16374
(CIF)
5 ILE A 276
SER A 235
GLY A 154
LEU A 278
SER A 160
None
1.25A 3ik6B-3gqjA:
undetectable
3ik6E-3gqjA:
undetectable
3ik6B-3gqjA:
21.00
3ik6E-3gqjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1


(Staphylococcus
aureus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 176
SER A 258
GLY A 273
LEU A 184
SER A 302
None
1.36A 3ik6B-3h3jA:
undetectable
3ik6E-3h3jA:
undetectable
3ik6B-3h3jA:
22.35
3ik6E-3h3jA:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
6 ILE A  92
PRO A 105
SER A 108
SER A 217
LYS A 218
GLY A 219
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
GOL  A 270 ( 3.0A)
None
None
0.34A 3ik6B-3h6tA:
43.4
3ik6E-3h6tA:
43.5
3ik6B-3h6tA:
100.00
3ik6E-3h6tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 ILE A 439
SER A 291
GLY A 433
SER A 295
LEU A 407
None
1.31A 3ik6B-3i8bA:
undetectable
3ik6E-3i8bA:
undetectable
3ik6B-3i8bA:
20.66
3ik6E-3i8bA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori)
PF01256
(Carb_kinase)
PF03853
(YjeF_N)
5 ILE A 420
SER A 252
GLY A 418
LEU A 424
SER A 425
None
1.28A 3ik6B-3k5wA:
undetectable
3ik6E-3k5wA:
undetectable
3ik6B-3k5wA:
20.09
3ik6E-3k5wA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kba PROGESTERONE
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 ILE A 804
PRO A 805
SER A 767
GLY A 764
LEU A 883
None
1.40A 3ik6B-3kbaA:
undetectable
3ik6E-3kbaA:
undetectable
3ik6B-3kbaA:
22.26
3ik6E-3kbaA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE


(Babesia bovis)
PF00274
(Glycolytic)
5 ILE A  70
SER A 296
LYS A  25
GLY A  26
LEU A  66
None
1.42A 3ik6B-3kx6A:
undetectable
3ik6E-3kx6A:
undetectable
3ik6B-3kx6A:
23.70
3ik6E-3kx6A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzd DPH2

(Pyrococcus
horikoshii)
PF01866
(Diphthamide_syn)
5 ILE A 178
PRO A 201
SER A 180
GLY A 179
LEU A 176
None
1.39A 3ik6B-3lzdA:
undetectable
3ik6E-3lzdA:
undetectable
3ik6B-3lzdA:
22.42
3ik6E-3lzdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ILE A 248
SER A  43
SER A  40
GLY A 245
LEU A 262
None
TPP  A 700 ( 4.3A)
TPP  A 700 (-2.5A)
None
None
1.43A 3ik6B-3mosA:
undetectable
3ik6E-3mosA:
undetectable
3ik6B-3mosA:
20.36
3ik6E-3mosA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803)
PF00654
(Voltage_CLC)
5 ILE A 293
GLY A 291
SER A 134
LEU A 297
SER A 298
None
1.32A 3ik6B-3nd0A:
undetectable
3ik6E-3nd0A:
undetectable
3ik6B-3nd0A:
17.20
3ik6E-3nd0A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njx RHAMNOGALACTURONASE
B


(Aspergillus
aculeatus)
PF09284
(RhgB_N)
PF14683
(CBM-like)
PF14686
(fn3_3)
5 ILE A  51
SER A  57
GLY A  54
SER A  26
LEU A  78
None
1.38A 3ik6B-3njxA:
undetectable
3ik6E-3njxA:
undetectable
3ik6B-3njxA:
16.93
3ik6E-3njxA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM


(Rhodopseudomonas
palustris)
no annotation 5 ILE B 147
PRO B 249
LYS B 149
GLY B 148
LYS B 212
None
0.82A 3ik6B-3nndB:
undetectable
3ik6E-3nndB:
undetectable
3ik6B-3nndB:
20.42
3ik6E-3nndB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE


(Staphylococcus
aureus)
PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C)
5 ILE A 337
SER A 341
LYS A 340
GLY A 339
LEU A 320
None
None
POP  A 377 (-2.9A)
None
None
1.13A 3ik6B-3orqA:
undetectable
3ik6E-3orqA:
undetectable
3ik6B-3orqA:
21.17
3ik6E-3orqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE


(Bacillus
subtilis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 175
SER A 258
GLY A 273
LEU A 183
SER A 302
None
1.16A 3ik6B-3pqdA:
undetectable
3ik6E-3pqdA:
undetectable
3ik6B-3pqdA:
22.85
3ik6E-3pqdA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py9 PROTEIN KINASE

(Staphylococcus
aureus)
PF03793
(PASTA)
5 ILE A  13
SER A  16
LYS A  15
GLY A  14
LYS A  49
None
1.15A 3ik6B-3py9A:
undetectable
3ik6E-3py9A:
undetectable
3ik6B-3py9A:
25.08
3ik6E-3py9A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyf CRISPR-ASSOCIATED
PROTEIN


(Sulfolobus
solfataricus)
PF09651
(Cas_APE2256)
5 ILE A 109
SER A  96
GLY A 106
LEU A 113
SER A 120
None
1.38A 3ik6B-3qyfA:
undetectable
3ik6E-3qyfA:
undetectable
3ik6B-3qyfA:
20.43
3ik6E-3qyfA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaj ENVELOPE PROTEIN

(Dengue virus)
no annotation 5 ILE B  61
SER B 122
GLY B 123
SER B  64
LEU B 218
None
0.97A 3ik6B-3uajB:
undetectable
3ik6E-3uajB:
undetectable
3ik6B-3uajB:
19.26
3ik6E-3uajB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes)
PF01515
(PTA_PTB)
5 ILE A 208
SER A 222
GLY A 224
SER A 199
LEU A 204
None
1.11A 3ik6B-3uf6A:
undetectable
3ik6E-3uf6A:
undetectable
3ik6B-3uf6A:
21.22
3ik6E-3uf6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235


(Bacillus
licheniformis)
PF13535
(ATP-grasp_4)
5 ILE A 307
SER A 304
LYS A 302
GLY A 306
LEU A 312
None
1.36A 3ik6B-3votA:
undetectable
3ik6E-3votA:
undetectable
3ik6B-3votA:
20.41
3ik6E-3votA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235


(Bacillus
licheniformis)
PF13535
(ATP-grasp_4)
5 SER A 304
LYS A 302
GLY A 306
SER A 221
LEU A 312
None
1.15A 3ik6B-3votA:
undetectable
3ik6E-3votA:
undetectable
3ik6B-3votA:
20.41
3ik6E-3votA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta)
PF04261
(Dyp_perox)
5 ILE A  11
GLY A  13
SER A 330
LEU A 198
SER A 216
None
1.23A 3ik6B-3vxiA:
undetectable
3ik6E-3vxiA:
undetectable
3ik6B-3vxiA:
19.73
3ik6E-3vxiA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I


(Anas
platyrhynchos)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2)
5 ILE A 137
PRO A 118
LYS A 152
GLY A 149
LEU A 129
None
1.41A 3ik6B-4a2qA:
undetectable
3ik6E-4a2qA:
undetectable
3ik6B-4a2qA:
15.65
3ik6E-4a2qA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am6 ACTIN-LIKE PROTEIN
ARP8


(Saccharomyces
cerevisiae)
PF00022
(Actin)
5 ILE A 278
PRO A 273
GLY A 274
SER A 407
LEU A 428
None
None
SO4  A1882 (-3.1A)
None
None
1.21A 3ik6B-4am6A:
undetectable
3ik6E-4am6A:
undetectable
3ik6B-4am6A:
17.25
3ik6E-4am6A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asl EPA1P

([Candida]
glabrata)
PF10528
(GLEYA)
5 ILE A 219
SER A 254
SER A  62
GLY A 147
LEU A 221
None
1.18A 3ik6B-4aslA:
undetectable
3ik6E-4aslA:
undetectable
3ik6B-4aslA:
22.80
3ik6E-4aslA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR BETA
SUBUNIT
ACETYLCHOLINE
RECEPTOR DELTA
SUBUNIT
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA


(Torpedo
marmorata)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
5 ILE A 247
SER B 250
SER B 254
SER C 258
LEU A 251
None
1.44A 3ik6B-4booA:
undetectable
3ik6E-4booA:
undetectable
3ik6B-4booA:
19.31
3ik6E-4booA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE


(Leishmania
major)
PF01233
(NMT)
PF02799
(NMT_C)
5 ILE A 235
PRO A 236
SER A 233
GLY A 234
SER A 221
None
1.44A 3ik6B-4cgnA:
undetectable
3ik6E-4cgnA:
undetectable
3ik6B-4cgnA:
20.40
3ik6E-4cgnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA


(Escherichia
coli)
PF02811
(PHP)
5 ILE A 107
PRO A 109
GLY A 102
LEU A  33
SER A  31
None
1.31A 3ik6B-4gx8A:
undetectable
3ik6E-4gx8A:
undetectable
3ik6B-4gx8A:
21.98
3ik6E-4gx8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica)
PF00291
(PALP)
5 ILE A 285
SER A 280
GLY A 282
SER A 308
LEU A  29
None
LLP  A  58 ( 2.5A)
None
LLP  A  58 ( 3.3A)
None
1.38A 3ik6B-4il5A:
undetectable
3ik6E-4il5A:
undetectable
3ik6B-4il5A:
22.81
3ik6E-4il5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itc LYS-GINGIPAIN W83

(Porphyromonas
gingivalis)
PF07675
(Cleaved_Adhesin)
5 ILE A 993
PRO A 994
SER A 988
GLY A 992
LEU A1045
GAI  A1206 (-4.0A)
GOL  A1207 ( 4.9A)
None
None
None
1.38A 3ik6B-4itcA:
undetectable
3ik6E-4itcA:
undetectable
3ik6B-4itcA:
21.17
3ik6E-4itcA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA


([Haemophilus]
ducreyi)
PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
5 ILE A 782
PRO A 773
GLY A 661
LYS A 776
SER A 666
None
1.09A 3ik6B-4k3cA:
undetectable
3ik6E-4k3cA:
undetectable
3ik6B-4k3cA:
20.24
3ik6E-4k3cA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A


(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
5 ILE A 126
PRO A 139
SER A 142
SER A 144
GLY A 251
None
1.29A 3ik6B-4kcdA:
29.7
3ik6E-4kcdA:
29.7
3ik6B-4kcdA:
29.70
3ik6E-4kcdA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1


(Bacillus cereus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 175
SER A 258
GLY A 273
LEU A 183
SER A 302
None
1.20A 3ik6B-4ln1A:
undetectable
3ik6E-4ln1A:
undetectable
3ik6B-4ln1A:
23.84
3ik6E-4ln1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae)
PF08801
(Nucleoporin_N)
5 ILE A 506
PRO A 543
GLY A 505
LEU A 599
SER A 576
None
1.22A 3ik6B-4mhcA:
undetectable
3ik6E-4mhcA:
undetectable
3ik6B-4mhcA:
15.74
3ik6E-4mhcA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS


(Desulfitobacterium
hafniense)
PF00809
(Pterin_bind)
5 ILE A 130
PRO A 131
SER A 128
GLY A 129
SER A 100
None
1.11A 3ik6B-4o1eA:
undetectable
3ik6E-4o1eA:
undetectable
3ik6B-4o1eA:
21.36
3ik6E-4o1eA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER


(Agrobacterium
tumefaciens)
PF13407
(Peripla_BP_4)
5 ILE A 213
GLY A 210
LYS A 201
SER A 230
LEU A 217
None
1.42A 3ik6B-4rxtA:
3.5
3ik6E-4rxtA:
3.3
3ik6B-4rxtA:
25.39
3ik6E-4rxtA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE


(Macrobdella
decora)
PF02973
(Sialidase)
PF13088
(BNR_2)
5 ILE A 398
SER A 370
SER A 321
LYS A 320
GLY A 397
None
1.27A 3ik6B-4sliA:
undetectable
3ik6E-4sliA:
undetectable
3ik6B-4sliA:
17.60
3ik6E-4sliA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae)
PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2)
5 ILE A 350
SER A 322
SER A 273
LYS A 272
GLY A 349
None
1.29A 3ik6B-4xhbA:
undetectable
3ik6E-4xhbA:
undetectable
3ik6B-4xhbA:
17.42
3ik6E-4xhbA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE


(Acinetobacter
virus AP22)
no annotation 5 ILE A 724
PRO A 656
SER A 722
GLY A 723
LYS A 654
None
1.31A 3ik6B-4y9vA:
undetectable
3ik6E-4y9vA:
undetectable
3ik6B-4y9vA:
16.01
3ik6E-4y9vA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE


(Vesicular
stomatitis
virus)
PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap)
5 ILE A 884
PRO A 933
SER A 952
GLY A 885
SER A1093
None
1.33A 3ik6B-5a22A:
undetectable
3ik6E-5a22A:
undetectable
3ik6B-5a22A:
8.17
3ik6E-5a22A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)


(Streptococcus
suis)
no annotation 5 ILE A 287
SER A 317
SER A 189
GLY A 195
LEU A 293
None
1.40A 3ik6B-5bobA:
undetectable
3ik6E-5bobA:
undetectable
3ik6B-5bobA:
21.30
3ik6E-5bobA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 ILE A 488
SER A 414
GLY A 487
LEU A 477
SER A 481
None
1.26A 3ik6B-5bs5A:
undetectable
3ik6E-5bs5A:
undetectable
3ik6B-5bs5A:
22.19
3ik6E-5bs5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Cryptococcus
neoformans)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 ILE A  23
SER A  87
GLY A  19
SER A 351
LEU A  34
None
1.39A 3ik6B-5cefA:
undetectable
3ik6E-5cefA:
undetectable
3ik6B-5cefA:
21.32
3ik6E-5cefA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghf AMINOTRANSFERASE
CLASS-III


(Ochrobactrum
anthropi)
PF00202
(Aminotran_3)
5 ILE A 430
PRO A 428
GLY A  63
SER A  59
LEU A 347
None
1.26A 3ik6B-5ghfA:
undetectable
3ik6E-5ghfA:
undetectable
3ik6B-5ghfA:
19.21
3ik6E-5ghfA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA


(Eptatretus
burgeri;
Mus musculus)
PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8)
5 ILE A 145
PRO A 144
SER A 142
SER A 115
LEU A 130
None
1.30A 3ik6B-5ijbA:
undetectable
3ik6E-5ijbA:
undetectable
3ik6B-5ijbA:
18.29
3ik6E-5ijbA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irp ALANINE RACEMASE 2

(Bacillus
subtilis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 ILE A 289
SER A 296
GLY A 290
SER A 300
LEU A 253
None
1.29A 3ik6B-5irpA:
undetectable
3ik6E-5irpA:
undetectable
3ik6B-5irpA:
21.64
3ik6E-5irpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2


(Homo sapiens)
PF01094
(ANF_receptor)
5 ILE A  90
SER A 352
GLY A  89
SER A 354
LEU A  93
None
1.24A 3ik6B-5kc8A:
undetectable
3ik6E-5kc8A:
undetectable
3ik6B-5kc8A:
19.63
3ik6E-5kc8A:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2


(Rattus
norvegicus)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
5 ILE A 481
PRO A 494
SER A 497
LYS A 730
GLY A 731
None
0.62A 3ik6B-5l1bA:
22.4
3ik6E-5l1bA:
22.6
3ik6B-5l1bA:
70.44
3ik6E-5l1bA:
70.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2


(Rattus
norvegicus)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
5 ILE A  90
SER A 352
GLY A  89
SER A 354
LEU A  93
None
1.23A 3ik6B-5l2eA:
27.8
3ik6E-5l2eA:
27.9
3ik6B-5l2eA:
16.59
3ik6E-5l2eA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lvc VP1

(Aichivirus A)
no annotation 5 ILE a  89
PRO a  54
GLY a  88
LEU a  93
SER a  94
None
0.95A 3ik6B-5lvca:
undetectable
3ik6E-5lvca:
undetectable
3ik6B-5lvca:
22.39
3ik6E-5lvca:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE


(Mus musculus)
no annotation 5 ILE A 399
SER A 393
GLY A 398
SER A 824
LEU A 463
None
1.43A 3ik6B-5mhfA:
undetectable
3ik6E-5mhfA:
undetectable
3ik6B-5mhfA:
15.60
3ik6E-5mhfA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila)
no annotation 5 ILE A 218
SER A 243
SER A 187
LEU A 210
SER A 211
None
ACT  A 504 (-2.6A)
ACT  A 504 (-4.0A)
None
None
1.41A 3ik6B-5n72A:
undetectable
3ik6E-5n72A:
undetectable
3ik6B-5n72A:
20.05
3ik6E-5n72A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN


(Pseudomonas
aeruginosa)
no annotation 5 ILE B 194
SER B 369
SER B 237
GLY B 241
SER B 186
None
1.16A 3ik6B-5n8nB:
undetectable
3ik6E-5n8nB:
undetectable
3ik6B-5n8nB:
14.40
3ik6E-5n8nB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B


(Cynara
cardunculus)
no annotation 5 ILE A  66
SER A 137
GLY A  67
SER A 110
LEU A  86
None
1.41A 3ik6B-5nfgA:
undetectable
3ik6E-5nfgA:
undetectable
3ik6B-5nfgA:
20.41
3ik6E-5nfgA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oev GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 22
(GPA-GSS22-APO)


(Globodera
pallida)
no annotation 5 ILE A 127
SER A 458
GLY A 441
SER A 192
LEU A 125
None
1.41A 3ik6B-5oevA:
undetectable
3ik6E-5oevA:
undetectable
3ik6B-5oevA:
17.05
3ik6E-5oevA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)


(Neisseria
gonorrhoeae)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A 301
SER A 286
GLY A 308
SER A 164
LEU A 299
None
FAD  A 601 ( 3.8A)
None
FAD  A 601 ( 3.9A)
None
1.32A 3ik6B-5u25A:
undetectable
3ik6E-5u25A:
undetectable
3ik6B-5u25A:
18.96
3ik6E-5u25A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis)
no annotation 5 ILE A 141
GLY A 338
LYS A  28
LEU A  32
SER A  34
None
0.96A 3ik6B-5uj1A:
undetectable
3ik6E-5uj1A:
undetectable
3ik6B-5uj1A:
14.92
3ik6E-5uj1A:
14.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN


(Mus musculus;
Rattus
norvegicus)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd)
6 ILE A 481
PRO A 494
SER A 497
SER A 729
LYS A 730
GLY A 731
None
0.73A 3ik6B-5welA:
32.5
3ik6E-5welA:
32.9
3ik6B-5welA:
66.93
3ik6E-5welA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA


(Mus musculus;
Rattus
norvegicus)
PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
6 ILE A 481
PRO A 494
SER A 497
SER A 729
LYS A 730
GLY A 731
None
CYZ  A1302 (-4.5A)
CYZ  A1302 (-3.2A)
None
GLU  A1301 ( 3.7A)
None
0.60A 3ik6B-5weoA:
25.3
3ik6E-5weoA:
25.2
3ik6B-5weoA:
66.93
3ik6E-5weoA:
66.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wue UNCHARACTERIZED
PROTEIN


(Sulfolobus
acidocaldarius)
PF03458
(UPF0126)
5 ILE A 138
GLY A 136
SER A  23
LEU A 142
SER A 143
None
0.99A 3ik6B-5wueA:
undetectable
3ik6E-5wueA:
undetectable
3ik6B-5wueA:
21.62
3ik6E-5wueA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER


(Pseudomonas
aeruginosa)
no annotation 5 ILE B  80
LYS B 157
GLY B  79
LEU B   4
SER B  28
None
1.35A 3ik6B-5x5yB:
undetectable
3ik6E-5x5yB:
undetectable
3ik6B-5x5yB:
22.30
3ik6E-5x5yB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1


(Homo sapiens)
PF15879
(MWFE)
5 ILE s 105
PRO s  88
GLY s 101
SER s 163
LEU s 237
None
1.19A 3ik6B-5xtds:
undetectable
3ik6E-5xtds:
undetectable
3ik6B-5xtds:
20.86
3ik6E-5xtds:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxe VARIABLE LYMPHOCYTE
RECEPTOR DIVERSITY
REGION


(Petromyzon
marinus)
no annotation 5 ILE A  47
PRO A  23
SER A  42
GLY A  45
LEU A  54
None
1.32A 3ik6B-6bxeA:
undetectable
3ik6E-6bxeA:
undetectable
3ik6B-6bxeA:
14.40
3ik6E-6bxeA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0d AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY


(Paraburkholderia
phymatum)
no annotation 5 ILE A  78
PRO A 187
SER A  80
GLY A  79
LEU A  76
None
None
ZN  A 501 ( 4.8A)
None
None
1.35A 3ik6B-6c0dA:
undetectable
3ik6E-6c0dA:
undetectable
3ik6B-6c0dA:
13.77
3ik6E-6c0dA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT


(Enterococcus
faecium)
no annotation 5 ILE A  77
SER A  70
GLY A  74
LEU A  32
SER A  66
None
1.35A 3ik6B-6cfdA:
undetectable
3ik6E-6cfdA:
undetectable
3ik6B-6cfdA:
15.29
3ik6E-6cfdA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE


(Burkholderia
cenocepacia)
no annotation 5 ILE A 192
SER A 202
GLY A 191
LYS A 196
LEU A 229
None
1.20A 3ik6B-6cmzA:
undetectable
3ik6E-6cmzA:
undetectable
3ik6B-6cmzA:
18.55
3ik6E-6cmzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE


(Plasmodium
vivax)
no annotation 5 ILE E 567
PRO E 568
LYS E 576
LEU E 580
SER E 582
None
1.16A 3ik6B-6d04E:
undetectable
3ik6E-6d04E:
undetectable
3ik6B-6d04E:
22.35
3ik6E-6d04E:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A


(Mus musculus)
no annotation 5 ILE A 438
PRO A 439
SER A 436
GLY A 437
LEU A 451
None
None
EDO  A 904 (-2.9A)
EDO  A 904 ( 3.4A)
None
1.43A 3ik6B-6fnwA:
undetectable
3ik6E-6fnwA:
undetectable
3ik6B-6fnwA:
15.89
3ik6E-6fnwA:
15.89