SIMILAR PATTERNS OF AMINO ACIDS FOR 3IK3_B_0LIB2_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4l | CELL DIVISIONPROTEIN KINASE 5 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 31VAL A 64HIS A 124LEU A 133ALA A 143 | None | 0.47A | 3ik3B-1h4lA:22.9 | 3ik3B-1h4lA:24.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | ALA A 220GLU A 236MET A 240LEU A 248HIS A 312LEU A 321 | None | 0.63A | 3ik3B-1k9aA:30.5 | 3ik3B-1k9aA:30.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | GLU A 236MET A 240LEU A 248VAL A 249HIS A 312LEU A 321 | None | 0.84A | 3ik3B-1k9aA:30.5 | 3ik3B-1k9aA:30.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | ALA A 288GLU A 305MET A 309ILE A 312LEU A 317HIS A 380LEU A 389ALA A 399 | P16 A 2 (-3.4A)P16 A 2 (-4.2A)P16 A 2 (-3.3A)NoneNoneNoneP16 A 2 (-4.4A)P16 A 2 (-3.5A) | 0.57A | 3ik3B-1opkA:34.6 | 3ik3B-1opkA:57.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | GLU A 305MET A 309LEU A 317VAL A 318HIS A 380LEU A 389 | P16 A 2 (-4.2A)P16 A 2 (-3.3A)NoneP16 A 2 ( 4.7A)NoneP16 A 2 (-4.4A) | 0.67A | 3ik3B-1opkA:34.6 | 3ik3B-1opkA:57.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 621GLU A 640HIS A 790LEU A 799ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.84A | 3ik3B-1t46A:29.2 | 3ik3B-1t46A:35.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 621GLU A 640VAL A 654HIS A 790LEU A 799ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.48A | 3ik3B-1t46A:29.2 | 3ik3B-1t46A:35.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u59 | TYROSINE-PROTEINKINASE ZAP-70 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 367GLU A 386MET A 390HIS A 459LEU A 468 | STU A 100 (-3.2A)NoneNoneNoneSTU A 100 (-4.5A) | 0.58A | 3ik3B-1u59A:31.3 | 3ik3B-1u59A:38.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA X 37GLU X 54MET X 58LEU X 66LEU X 137ALA X 147 | STU X 902 (-3.1A)STU X 902 ( 4.4A)NoneNoneSTU X 902 (-4.4A)STU X 902 ( 4.1A) | 0.67A | 3ik3B-2dq7X:32.1 | 3ik3B-2dq7X:44.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA X 37MET X 58LEU X 66HIS X 128LEU X 137ALA X 147 | STU X 902 (-3.1A)NoneNoneNoneSTU X 902 (-4.4A)STU X 902 ( 4.1A) | 0.55A | 3ik3B-2dq7X:32.1 | 3ik3B-2dq7X:44.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | GLU X 54MET X 58LEU X 66VAL X 67LEU X 137ALA X 147 | STU X 902 ( 4.4A)NoneNoneNoneSTU X 902 (-4.4A)STU X 902 ( 4.1A) | 0.81A | 3ik3B-2dq7X:32.1 | 3ik3B-2dq7X:44.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | MET X 58LEU X 66VAL X 67HIS X 128LEU X 137ALA X 147 | NoneNoneNoneNoneSTU X 902 (-4.4A)STU X 902 ( 4.1A) | 0.74A | 3ik3B-2dq7X:32.1 | 3ik3B-2dq7X:44.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eu9 | DUAL SPECIFICITYPROTEIN KINASE CLK3 (Homo sapiens) |
PF00069(Pkinase) | 7 | ALA A 184GLU A 201ILE A 208VAL A 220HIS A 281LEU A 290ALA A 319 | None | 0.69A | 3ik3B-2eu9A:21.3 | 3ik3B-2eu9A:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8h | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | ALA A 293LEU A 322VAL A 323HIS A 384LEU A 393ALA A 403 | H8H A 534 (-3.2A)NoneNoneNoneH8H A 534 (-4.5A)H8H A 534 ( 4.0A) | 0.83A | 3ik3B-2h8hA:30.2 | 3ik3B-2h8hA:27.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hck | HEMATOPOETIC CELLKINASE HCK (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | ALA A 293LEU A 322VAL A 323HIS A 384LEU A 393ALA A 403 | QUE A 1 (-3.5A)NoneNoneNoneQUE A 1 (-4.4A)QUE A 1 ( 4.5A) | 0.64A | 3ik3B-2hckA:29.8 | 3ik3B-2hckA:31.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 271MET A 292LEU A 300VAL A 301HIS A 362LEU A 371ALA A 381 | 1BM A 499 (-3.6A)1BM A 499 ( 3.8A)NoneNoneNone1BM A 499 (-4.4A)1BM A 499 ( 3.7A) | 0.80A | 3ik3B-2hk5A:26.9 | 3ik3B-2hk5A:46.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 269GLU A 286MET A 290ILE A 293LEU A 298LEU A 370ALA A 380 | GIN A 600 (-3.1A)GIN A 600 (-3.6A)GIN A 600 (-3.2A)GIN A 600 (-4.5A)GIN A 600 (-4.2A)GIN A 600 (-4.7A)GIN A 600 (-3.1A) | 0.39A | 3ik3B-2hz0A:33.9 | 3ik3B-2hz0A:98.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 269MET A 290ILE A 293LEU A 298HIS A 361LEU A 370ALA A 380 | GIN A 600 (-3.1A)GIN A 600 (-3.2A)GIN A 600 (-4.5A)GIN A 600 (-4.2A)GIN A 600 (-4.3A)GIN A 600 (-4.7A)GIN A 600 (-3.1A) | 0.62A | 3ik3B-2hz0A:33.9 | 3ik3B-2hz0A:98.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | GLU A 286MET A 290ILE A 293LEU A 298VAL A 299LEU A 370ALA A 380ASP A 381 | GIN A 600 (-3.6A)GIN A 600 (-3.2A)GIN A 600 (-4.5A)GIN A 600 (-4.2A)GIN A 600 (-4.6A)GIN A 600 (-4.7A)GIN A 600 (-3.1A)GIN A 600 (-4.9A) | 0.81A | 3ik3B-2hz0A:33.9 | 3ik3B-2hz0A:98.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | MET A 290ILE A 293LEU A 298VAL A 299HIS A 361LEU A 370ALA A 380ASP A 381 | GIN A 600 (-3.2A)GIN A 600 (-4.5A)GIN A 600 (-4.2A)GIN A 600 (-4.6A)GIN A 600 (-4.3A)GIN A 600 (-4.7A)GIN A 600 (-3.1A)GIN A 600 (-4.9A) | 0.75A | 3ik3B-2hz0A:33.9 | 3ik3B-2hz0A:98.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0j | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF00373(FERM_M)PF07714(Pkinase_Tyr) | 5 | ALA A 452GLU A 471MET A 475HIS A 544LEU A 553 | 4ST A1687 (-3.3A)4ST A1687 ( 4.6A)NoneNone4ST A1687 (-4.4A) | 0.58A | 3ik3B-2j0jA:32.5 | 3ik3B-2j0jA:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgz | CELL DIVISIONPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 31GLU A 51VAL A 64LEU A 134ALA A 144 | None | 0.55A | 3ik3B-2jgzA:23.0 | 3ik3B-2jgzA:27.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgz | CELL DIVISIONPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 31VAL A 64HIS A 125LEU A 134ALA A 144 | None | 0.39A | 3ik3B-2jgzA:23.0 | 3ik3B-2jgzA:27.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | ALA A 271GLU A 288MET A 292LEU A 300VAL A 301HIS A 362LEU A 371ALA A 381ASP A 382PHE A 383 | 1N8 A 501 ( 3.4A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.9A)NoneNone1N8 A 501 ( 4.3A)1N8 A 501 ( 3.3A)1N8 A 501 ( 3.3A)1N8 A 501 ( 4.3A) | 0.62A | 3ik3B-2og8A:32.0 | 3ik3B-2og8A:44.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p4i | ANGIOPOIETIN-1RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 853ILE A 902HIS A 962LEU A 971ALA A 981ASP A 982PHE A 983 | MR9 A 301 (-3.5A)MR9 A 301 (-4.1A)MR9 A 301 (-4.5A)MR9 A 301 (-4.5A)MR9 A 301 (-3.2A)MR9 A 301 (-4.2A)MR9 A 301 (-4.4A) | 0.54A | 3ik3B-2p4iA:23.3 | 3ik3B-2p4iA:38.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 515GLU A 534MET A 538ILE A 541HIS A 624LEU A 633ALA A 643 | None | 0.70A | 3ik3B-2psqA:31.8 | 3ik3B-2psqA:33.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlu | ACTIVIN RECEPTORTYPE IIB (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 215LEU A 244HIS A 319LEU A 328ALA A 338 | ADE A 488 (-3.2A)NoneNoneADE A 488 (-4.4A)None | 0.50A | 3ik3B-2qluA:24.4 | 3ik3B-2qluA:23.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r4b | RECEPTORTYROSINE-PROTEINKINASE ERBB-4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 749LEU A 780VAL A 781HIS A 841LEU A 850 | GW7 A 1 (-3.3A)NoneGW7 A 1 ( 4.7A)NoneGW7 A 1 (-4.2A) | 0.71A | 3ik3B-2r4bA:29.0 | 3ik3B-2r4bA:35.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 5 | ALA A 273LEU A 302HIS A 365LEU A 374ALA A 384 | None | 0.44A | 3ik3B-2zv7A:25.6 | 3ik3B-2zv7A:45.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 515MET A 538HIS A 624LEU A 633ALA A 643 | M33 A1996 (-3.3A)NoneNoneM33 A1996 (-4.5A)None | 0.55A | 3ik3B-3b2tA:25.6 | 3ik3B-3b2tA:39.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 512GLU A 531HIS A 621LEU A 630ALA A 640 | C4F A 1 (-3.3A)NoneNoneC4F A 1 (-4.6A)C4F A 1 (-3.6A) | 0.49A | 3ik3B-3c4fA:25.2 | 3ik3B-3c4fA:40.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 512MET A 535HIS A 621LEU A 630ALA A 640 | C4F A 1 (-3.3A)C4F A 1 ( 3.7A)NoneC4F A 1 (-4.6A)C4F A 1 (-3.6A) | 0.49A | 3ik3B-3c4fA:25.2 | 3ik3B-3c4fA:40.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 220GLU A 236MET A 240LEU A 248HIS A 312LEU A 321 | None | 0.63A | 3ik3B-3d7uA:31.2 | 3ik3B-3d7uA:44.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | GLU A 236MET A 240LEU A 248VAL A 249HIS A 312LEU A 321 | None | 0.84A | 3ik3B-3d7uA:31.2 | 3ik3B-3d7uA:44.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dko | EPHRIN TYPE-ARECEPTOR 7 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 7 | ALA A 663GLU A 682MET A 686VAL A 695HIS A 756ASP A 776PHE A 777 | IHZ A1001 (-3.3A)IHZ A1001 (-3.8A)IHZ A1001 (-3.5A)IHZ A1001 ( 4.9A)IHZ A1001 ( 4.9A)IHZ A1001 (-4.8A)IHZ A1001 (-4.7A) | 0.76A | 3ik3B-3dkoA:30.9 | 3ik3B-3dkoA:36.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dko | EPHRIN TYPE-ARECEPTOR 7 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 7 | ALA A 663VAL A 695ILE A 711HIS A 756LEU A 765ASP A 776PHE A 777 | IHZ A1001 (-3.3A)IHZ A1001 ( 4.9A)IHZ A1001 (-3.8A)IHZ A1001 ( 4.9A)IHZ A1001 (-4.6A)IHZ A1001 (-4.8A)IHZ A1001 (-4.7A) | 0.86A | 3ik3B-3dkoA:30.9 | 3ik3B-3dkoA:36.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 859GLU A 878HIS A1020LEU A1029ASP A1040PHE A1041 | 8ST A2001 ( 3.8A)8ST A2001 (-3.7A)8ST A2001 ( 4.8A)NoneNone8ST A2001 ( 3.7A) | 0.93A | 3ik3B-3hngA:33.0 | 3ik3B-3hngA:33.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kul | EPHRIN TYPE-ARECEPTOR 8 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 5 | ALA A 665GLU A 684MET A 688HIS A 758LEU A 767 | None | 0.54A | 3ik3B-3kulA:25.8 | 3ik3B-3kulA:34.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mi9 | CELL DIVISIONPROTEIN KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 46GLU A 66VAL A 79LEU A 156ALA A 166 | None | 0.56A | 3ik3B-3mi9A:22.7 | 3ik3B-3mi9A:26.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mi9 | CELL DIVISIONPROTEIN KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 46VAL A 79HIS A 147LEU A 156ALA A 166 | None | 0.50A | 3ik3B-3mi9A:22.7 | 3ik3B-3mi9A:26.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3niz | RHODANESE FAMILYPROTEIN (Cryptosporidiumparvum) |
PF00069(Pkinase) | 5 | ALA A 49VAL A 82HIS A 142LEU A 151ALA A 161 | ADP A 314 (-3.5A)NoneNoneADP A 314 (-4.6A)None | 0.57A | 3ik3B-3nizA:22.6 | 3ik3B-3nizA:27.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 109GLU A 130MET A 134HIS A 203LEU A 212 | JOZ A 361 (-3.4A)SO4 A 5 (-3.1A)NoneNoneNone | 0.57A | 3ik3B-3nuuA:22.8 | 3ik3B-3nuuA:26.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 5 | ALA A 576GLU A 596MET A 600HIS A 674LEU A 683 | STU A 1 (-3.3A)NoneNoneNoneSTU A 1 (-4.3A) | 0.53A | 3ik3B-3ppzA:28.4 | 3ik3B-3ppzA:32.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 5 | ALA A 576MET A 600VAL A 609HIS A 674LEU A 683 | STU A 1 (-3.3A)NoneNoneNoneSTU A 1 (-4.3A) | 0.71A | 3ik3B-3ppzA:28.4 | 3ik3B-3ppzA:32.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3sxs | CYTOPLASMICTYROSINE-PROTEINKINASE BMX (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 443MET A 464LEU A 472VAL A 473HIS A 534LEU A 543 | PP2 A 1 (-3.2A)PP2 A 1 ( 4.3A)NoneNoneNonePP2 A 1 (-4.6A) | 0.68A | 3ik3B-3sxsA:31.3 | 3ik3B-3sxsA:41.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 512GLU A 531MET A 535HIS A 621LEU A 630ALA A 640 | 07J A 1 (-3.5A)07J A 1 (-3.8A)07J A 1 (-3.8A)None07J A 1 ( 4.4A)07J A 1 (-3.2A) | 0.57A | 3ik3B-3tt0A:30.6 | 3ik3B-3tt0A:34.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v5q | NT-3 GROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 570VAL A 601HIS A 677LEU A 686ASP A 697 | 0F4 A 902 (-3.2A)None0F4 A 902 (-4.1A)0F4 A 902 (-4.5A)None | 0.68A | 3ik3B-3v5qA:28.8 | 3ik3B-3v5qA:36.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vid | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 866GLU A 885HIS A1026LEU A1035ASP A1046 | 4TT A2001 (-3.5A)NoneNone4TT A2001 (-4.8A)None | 0.62A | 3ik3B-3vidA:30.4 | 3ik3B-3vidA:33.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vid | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 866GLU A 885ILE A 892HIS A1026ASP A1046 | 4TT A2001 (-3.5A)NoneNoneNoneNone | 0.64A | 3ik3B-3vidA:30.4 | 3ik3B-3vidA:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdu | CYCLIN-DEPENDENTKINASE-LIKE 3 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 31LEU A 62VAL A 63HIS A 123LEU A 132 | 38R A 350 (-3.4A)None38R A 350 ( 4.9A)None38R A 350 (-4.3A) | 0.64A | 3ik3B-3zduA:22.0 | 3ik3B-3zduA:28.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4agu | CYCLIN-DEPENDENTKINASE-LIKE 1 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 31GLU A 51LEU A 63VAL A 64HIS A 124LEU A 133 | D15 A 500 (-3.4A)NoneNoneNoneNoneD15 A 500 (-4.5A) | 0.62A | 3ik3B-4aguA:22.5 | 3ik3B-4aguA:28.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc6 | SERINE/THREONINE-PROTEIN KINASE 10 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 63GLU A 81VAL A 94ILE A 110LEU A 164ALA A 174 | XZN A1317 (-3.5A)XZN A1317 (-3.9A)XZN A1317 (-4.4A)XZN A1317 (-3.3A)XZN A1317 (-4.7A)XZN A1317 ( 4.3A) | 0.73A | 3ik3B-4bc6A:21.5 | 3ik3B-4bc6A:29.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc6 | SERINE/THREONINE-PROTEIN KINASE 10 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 63VAL A 94ILE A 110HIS A 155LEU A 164ALA A 174 | XZN A1317 (-3.5A)XZN A1317 (-4.4A)XZN A1317 (-3.3A)NoneXZN A1317 (-4.7A)XZN A1317 ( 4.3A) | 0.72A | 3ik3B-4bc6A:21.5 | 3ik3B-4bc6A:29.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ckr | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 653GLU A 672MET A 676HIS A 764LEU A 773ALA A 783ASP A 784 | DI1 A1000 (-3.6A)DI1 A1000 (-3.8A)DI1 A1000 (-3.6A)DI1 A1000 (-3.8A)DI1 A1000 (-4.5A)DI1 A1000 (-3.7A)DI1 A1000 (-4.1A) | 0.68A | 3ik3B-4ckrA:32.4 | 3ik3B-4ckrA:36.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ckr | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | MET A 676HIS A 764LEU A 773ALA A 783ASP A 784PHE A 785 | DI1 A1000 (-3.6A)DI1 A1000 (-3.8A)DI1 A1000 (-4.5A)DI1 A1000 (-3.7A)DI1 A1000 (-4.1A)DI1 A1000 (-4.5A) | 0.75A | 3ik3B-4ckrA:32.4 | 3ik3B-4ckrA:36.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 5 | ALA A 684GLU A 705LEU A 720LEU A 789ALA A 799 | AGS A1985 (-3.5A)NoneNoneAGS A1985 (-4.8A)AGS A1985 ( 4.5A) | 0.61A | 3ik3B-4crsA:20.6 | 3ik3B-4crsA:26.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 853GLU A 871HIS A 947LEU A 956ALA A 966 | 19S A1201 (-3.3A)NoneNone19S A1201 (-4.5A)19S A1201 ( 4.1A) | 0.48A | 3ik3B-4hviA:24.7 | 3ik3B-4hviA:35.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 5 | ALA A 293LEU A 322HIS A 384LEU A 393ALA A 403 | 0J9 A 601 (-3.3A)NoneNone0J9 A 601 (-4.5A)0J9 A 601 (-3.5A) | 0.27A | 3ik3B-4k11A:30.1 | 3ik3B-4k11A:34.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 5 | ALA A 293LEU A 322VAL A 323HIS A 384ALA A 403 | 0J9 A 601 (-3.3A)NoneNoneNone0J9 A 601 (-3.5A) | 0.70A | 3ik3B-4k11A:30.1 | 3ik3B-4k11A:34.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 506GLU A 525MET A 529ILE A 532LEU A 624ALA A 634 | ACP A 801 (-3.3A)ACP A 801 ( 4.8A)NoneNoneACP A 801 (-4.4A)None | 0.75A | 3ik3B-4k33A:25.7 | 3ik3B-4k33A:37.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 506ILE A 532HIS A 615LEU A 624ALA A 634 | ACP A 801 (-3.3A)NoneNoneACP A 801 (-4.4A)None | 0.59A | 3ik3B-4k33A:25.7 | 3ik3B-4k33A:37.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lgg | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Gallus gallus) |
PF07714(Pkinase_Tyr) | 6 | ALA A 293LEU A 322VAL A 323HIS A 384LEU A 393ALA A 403 | VGG A 601 (-3.5A)NoneVGG A 601 ( 4.8A)NoneVGG A 601 (-4.5A)VGG A 601 ( 4.2A) | 0.69A | 3ik3B-4lggA:29.6 | 3ik3B-4lggA:46.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o2z | MITOGEN-ACTIVATEDPROTEIN KINASE 3,PUTATIVE (Leishmaniadonovani) |
PF00069(Pkinase) | 5 | GLU A 94MET A 98LEU A 106HIS A 173ASP A 193 | 046 A 401 (-3.7A)046 A 401 (-3.5A)046 A 401 ( 4.6A)046 A 401 (-4.1A)046 A 401 (-4.3A) | 0.63A | 3ik3B-4o2zA:21.6 | 3ik3B-4o2zA:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oav | PROTEIN (RNASE L) (Homo sapiens) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A)PF12796(Ank_2)PF13857(Ank_5) | 5 | ALA B 390LEU B 417HIS B 483LEU B 492ALA B 502 | ACP B 801 (-3.2A)NoneNoneACP B 801 (-4.5A)None | 0.57A | 3ik3B-4oavB:16.6 | 3ik3B-4oavB:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oav | PROTEIN (RNASE L) (Homo sapiens) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A)PF12796(Ank_2)PF13857(Ank_5) | 5 | LEU B 417VAL B 418HIS B 483LEU B 492ALA B 502 | NoneNoneNoneACP B 801 (-4.5A)None | 0.70A | 3ik3B-4oavB:16.6 | 3ik3B-4oavB:17.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 642GLU A 661HIS A 809LEU A 818ASP A 829 | P30 A1001 (-3.4A)P30 A1001 (-3.6A)P30 A1001 ( 4.3A)P30 A1001 (-4.6A)None | 0.42A | 3ik3B-4rt7A:35.0 | 3ik3B-4rt7A:31.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tpt | LIM DOMAIN KINASE 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | HIS A 449LEU A 458ALA A 468ASP A 469PHE A 470 | 35H A 701 ( 4.4A)None35H A 701 (-3.5A)35H A 701 (-4.7A)35H A 701 (-4.4A) | 0.44A | 3ik3B-4tptA:21.8 | 3ik3B-4tptA:28.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 6 | ALA A 35LEU A 64VAL A 65HIS A 127LEU A 136ALA A 146 | ACP A1264 (-2.9A)NoneNoneNoneACP A1264 ( 4.8A)None | 0.52A | 3ik3B-4ueuA:31.9 | 3ik3B-4ueuA:63.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4usf | STE20-LIKESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 61VAL A 92HIS A 153LEU A 162ALA A 172ASP A 173 | 6UI A 700 (-3.3A)NoneNone6UI A 700 (-4.2A)6UI A 700 ( 4.1A)None | 0.73A | 3ik3B-4usfA:24.4 | 3ik3B-4usfA:29.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 501GLU A 520MET A 524HIS A 610LEU A 619ALA A 629 | 40M A1002 ( 4.1A)40M A1002 (-3.7A)40M A1002 (-3.8A)None40M A1002 (-4.5A)40M A1002 (-3.0A) | 0.54A | 3ik3B-4xcuA:25.7 | 3ik3B-4xcuA:39.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xey | TYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
no annotation | 7 | ALA B 288MET B 309ILE B 312LEU B 317HIS B 380LEU B 389ALA B 399 | 1N1 B 601 (-3.5A)1N1 B 601 (-3.7A)NoneNoneNone1N1 B 601 (-4.3A)1N1 B 601 (-3.5A) | 0.59A | 3ik3B-4xeyB:30.1 | 3ik3B-4xeyB:92.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 642GLU A 661HIS A 809LEU A 818ASP A 829 | P30 A1001 (-3.5A)P30 A1001 (-3.1A)P30 A1001 (-4.4A)P30 A1001 (-4.3A)None | 0.48A | 3ik3B-4xufA:33.2 | 3ik3B-4xufA:37.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | GLU A 661HIS A 809LEU A 818ASP A 829PHE A 830 | P30 A1001 (-3.1A)P30 A1001 (-4.4A)P30 A1001 (-4.3A)NoneP30 A1001 ( 4.1A) | 0.65A | 3ik3B-4xufA:33.2 | 3ik3B-4xufA:37.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | GLU A 661VAL A 675HIS A 809LEU A 818ASP A 829 | P30 A1001 (-3.1A)NoneP30 A1001 (-4.4A)P30 A1001 (-4.3A)None | 0.57A | 3ik3B-4xufA:33.2 | 3ik3B-4xufA:37.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 512GLU A 531MET A 535HIS A 621LEU A 630ALA A 640 | 38O A1769 (-3.6A)EDO A1766 (-4.1A)EDO A1766 (-3.5A)None38O A1769 (-4.6A)EDO A1766 ( 4.4A) | 0.52A | 3ik3B-5a46A:25.0 | 3ik3B-5a46A:36.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 625GLU A 644MET A 648HIS A 816LEU A 825ASP A 836 | 748 A1001 (-3.7A)748 A1001 (-3.3A)748 A1001 (-3.4A)748 A1001 (-3.8A)748 A1001 (-4.3A)748 A1001 (-4.8A) | 0.51A | 3ik3B-5grnA:34.6 | 3ik3B-5grnA:33.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | GLU A 644MET A 648VAL A 658HIS A 816LEU A 825ASP A 836 | 748 A1001 (-3.3A)748 A1001 (-3.4A)748 A1001 ( 4.8A)748 A1001 (-3.8A)748 A1001 (-4.3A)748 A1001 (-4.8A) | 0.70A | 3ik3B-5grnA:34.6 | 3ik3B-5grnA:33.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hu3 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE II ALPHACHAIN (Drosophilamelanogaster) |
PF00069(Pkinase) | 5 | ALA A 41GLU A 61VAL A 74LEU A 143ALA A 156 | ADP A 301 (-3.5A)NoneNoneADP A 301 (-4.7A)ADP A 301 ( 4.8A) | 0.59A | 3ik3B-5hu3A:12.5 | 3ik3B-5hu3A:26.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hu3 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE II ALPHACHAIN (Drosophilamelanogaster) |
PF00069(Pkinase) | 5 | ALA A 41VAL A 74HIS A 134LEU A 143ALA A 156 | ADP A 301 (-3.5A)NoneNoneADP A 301 (-4.7A)ADP A 301 ( 4.8A) | 0.42A | 3ik3B-5hu3A:12.5 | 3ik3B-5hu3A:26.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hx6 | RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 76HIS A 136LEU A 145ALA A 155ASP A 156 | 65U A 301 (-4.7A)65U A 301 (-3.3A)None65U A 301 ( 3.9A)65U A 301 (-4.7A) | 0.70A | 3ik3B-5hx6A:21.6 | 3ik3B-5hx6A:30.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5t | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE KINASE3 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 43GLU A 61MET A 65HIS A 134LEU A 143ALA A 153 | 6G2 A 901 (-3.2A)NoneNoneNone6G2 A 901 (-4.7A)6G2 A 901 ( 4.2A) | 0.70A | 3ik3B-5j5tA:21.5 | 3ik3B-5j5tA:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kbr | SERINE/THREONINE-PROTEIN KINASE PAK 1 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 297GLU A 315MET A 319HIS A 387LEU A 396 | IPW A 601 (-3.5A)IPW A 601 (-3.9A)IPW A 601 (-4.1A)NoneIPW A 601 (-4.5A) | 0.69A | 3ik3B-5kbrA:21.5 | 3ik3B-5kbrA:24.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lpy | PROTEINBRASSINOSTEROIDINSENSITIVE 1 (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | ALA A 909GLU A 927LEU A 939VAL A 940LEU A1016 | ATP A1200 (-3.5A)NoneNoneNoneATP A1200 (-4.6A) | 0.71A | 3ik3B-5lpyA:22.2 | 3ik3B-5lpyA:29.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lpy | PROTEINBRASSINOSTEROIDINSENSITIVE 1 (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | ALA A 909LEU A 939VAL A 940HIS A1007LEU A1016 | ATP A1200 (-3.5A)NoneNoneNoneATP A1200 (-4.6A) | 0.57A | 3ik3B-5lpyA:22.2 | 3ik3B-5lpyA:29.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lpz | PROTEINBRASSINOSTEROIDINSENSITIVE 1 (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | ALA A 909LEU A 939VAL A 940HIS A1007LEU A1016 | ADP A1200 (-3.5A)NoneNoneNoneADP A1200 (-4.7A) | 0.58A | 3ik3B-5lpzA:22.2 | 3ik3B-5lpzA:29.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5myv | SRSF PROTEIN KINASE2,SRSF PROTEINKINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 119GLU A 136VAL A 157HIS A 223ALA A 540 | W4A A 716 ( 3.9A)DMS A 717 (-4.0A)DMS A 717 (-4.3A)NoneDMS A 717 ( 4.5A) | 0.67A | 3ik3B-5myvA:19.8 | 3ik3B-5myvA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5myv | SRSF PROTEIN KINASE2,SRSF PROTEINKINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 5 | GLU A 136VAL A 157HIS A 223LEU A 232ALA A 540 | DMS A 717 (-4.0A)DMS A 717 (-4.3A)NoneNoneDMS A 717 ( 4.5A) | 0.53A | 3ik3B-5myvA:19.8 | 3ik3B-5myvA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7s | FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE (Acinetobacterbaumannii) |
PF01116(F_bP_aldolase) | 6 | ALA A 22ILE A 192LEU A 229VAL A 230LEU A 10ALA A 189 | None | 1.32A | 3ik3B-5u7sA:undetectable | 3ik3B-5u7sA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xv7 | SERINE-ARGININE (SR)PROTEIN KINASE 1 (Homo sapiens) |
no annotation | 5 | ALA A 107GLU A 124VAL A 145HIS A 211ALA A 496 | EMH A 705 (-3.6A)NoneEMH A 705 ( 4.9A)NoneEMH A 705 ( 4.0A) | 0.52A | 3ik3B-5xv7A:20.5 | 3ik3B-5xv7A:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xv7 | SERINE-ARGININE (SR)PROTEIN KINASE 1 (Homo sapiens) |
no annotation | 5 | GLU A 124VAL A 145HIS A 211LEU A 220ALA A 496 | NoneEMH A 705 ( 4.9A)NoneNoneEMH A 705 ( 4.0A) | 0.62A | 3ik3B-5xv7A:20.5 | 3ik3B-5xv7A:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ao5 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
no annotation | 5 | ALA A 54VAL A 83HIS A 144LEU A 153ALA A 163 | ANP A 501 ( 3.7A)NoneNoneANP A 501 (-4.6A)None | 0.72A | 3ik3B-6ao5A:21.9 | 3ik3B-6ao5A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b3e | CYCLIN-DEPENDENTKINASE 12 (Homo sapiens) |
no annotation | 6 | ALA A 754GLU A 774VAL A 787HIS A 857LEU A 866ALA A 876 | CJM A1102 (-3.1A)NoneNoneNoneCJM A1102 (-4.4A)CJM A1102 (-3.6A) | 0.56A | 3ik3B-6b3eA:23.3 | 3ik3B-6b3eA:16.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bql | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE KINASE 2 (Homo sapiens) |
no annotation | 5 | ALA A 192VAL A 249HIS A 310LEU A 319ALA A 329 | BI9 A 501 (-3.3A)NoneNoneBI9 A 501 (-4.7A)NH4 A 506 ( 3.7A) | 0.53A | 3ik3B-6bqlA:21.6 | 3ik3B-6bqlA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccf | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE KINASE 1 (Homo sapiens) |
no annotation | 5 | ALA A 155VAL A 212HIS A 273LEU A 282ALA A 292 | H1N A 501 (-3.4A)H1N A 501 (-4.9A)NoneH1N A 501 (-4.8A)H1N A 501 ( 3.9A) | 0.50A | 3ik3B-6ccfA:21.9 | 3ik3B-6ccfA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cmj | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE KINASE 2 (Homo sapiens) |
no annotation | 5 | ALA A 192VAL A 249HIS A 310LEU A 319ALA A 329 | F6J A 501 (-3.4A)NoneNoneF6J A 501 (-4.5A)F6J A 501 ( 4.0A) | 0.48A | 3ik3B-6cmjA:22.0 | 3ik3B-6cmjA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cnh | SERINE/THREONINE-PROTEIN KINASE PRP4HOMOLOG (Homo sapiens) |
no annotation | 5 | ALA A 715GLU A 732HIS A 813LEU A 822ASP A 834 | 919 A1101 (-3.5A)919 A1101 (-3.7A)919 A1101 (-4.2A)None919 A1101 (-4.5A) | 0.49A | 3ik3B-6cnhA:21.2 | 3ik3B-6cnhA:14.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cnh | SERINE/THREONINE-PROTEIN KINASE PRP4HOMOLOG (Homo sapiens) |
no annotation | 5 | GLU A 732HIS A 813LEU A 822ASP A 834PHE A 835 | 919 A1101 (-3.7A)919 A1101 (-4.2A)None919 A1101 (-4.5A)919 A1101 ( 4.1A) | 0.42A | 3ik3B-6cnhA:21.2 | 3ik3B-6cnhA:14.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3d | INTERLEUKIN-1RECEPTOR-ASSOCIATEDKINASE 4 (Homo sapiens) |
no annotation | 5 | ALA A 211LEU A 245VAL A 246HIS A 309LEU A 318 | CJT A 502 (-3.4A)NoneNoneNoneCJT A 502 (-4.7A) | 0.62A | 3ik3B-6f3dA:23.0 | 3ik3B-6f3dA:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fdy | - (-) |
no annotation | 5 | ALA U 42VAL U 75HIS U 135LEU U 144ALA U 156 | DB8 U 301 (-3.6A)DB8 U 301 (-4.8A)NoneDB8 U 301 (-4.8A)DB8 U 301 ( 4.2A) | 0.67A | 3ik3B-6fdyU:21.6 | 3ik3B-6fdyU:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fyl | DUAL SPECIFICITYPROTEIN KINASE CLK2 (Homo sapiens) |
no annotation | 6 | ALA A 191GLU A 208ILE A 215VAL A 227HIS A 288LEU A 297 | 3NG A 501 (-3.3A)3NG A 501 ( 4.9A)NoneNoneNoneNone | 0.79A | 3ik3B-6fylA:21.5 | 3ik3B-6fylA:undetectable |