SIMILAR PATTERNS OF AMINO ACIDS FOR 3IK3_B_0LIB2_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  31
VAL A  64
HIS A 124
LEU A 133
ALA A 143
None
0.47A 3ik3B-1h4lA:
22.9
3ik3B-1h4lA:
24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 ALA A 220
GLU A 236
MET A 240
LEU A 248
HIS A 312
LEU A 321
None
0.63A 3ik3B-1k9aA:
30.5
3ik3B-1k9aA:
30.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 GLU A 236
MET A 240
LEU A 248
VAL A 249
HIS A 312
LEU A 321
None
0.84A 3ik3B-1k9aA:
30.5
3ik3B-1k9aA:
30.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 ALA A 288
GLU A 305
MET A 309
ILE A 312
LEU A 317
HIS A 380
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.57A 3ik3B-1opkA:
34.6
3ik3B-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 GLU A 305
MET A 309
LEU A 317
VAL A 318
HIS A 380
LEU A 389
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
None
P16  A   2 (-4.4A)
0.67A 3ik3B-1opkA:
34.6
3ik3B-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 621
GLU A 640
HIS A 790
LEU A 799
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.84A 3ik3B-1t46A:
29.2
3ik3B-1t46A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 621
GLU A 640
VAL A 654
HIS A 790
LEU A 799
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.48A 3ik3B-1t46A:
29.2
3ik3B-1t46A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 367
GLU A 386
MET A 390
HIS A 459
LEU A 468
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-4.5A)
0.58A 3ik3B-1u59A:
31.3
3ik3B-1u59A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA X  37
GLU X  54
MET X  58
LEU X  66
LEU X 137
ALA X 147
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
0.67A 3ik3B-2dq7X:
32.1
3ik3B-2dq7X:
44.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA X  37
MET X  58
LEU X  66
HIS X 128
LEU X 137
ALA X 147
STU  X 902 (-3.1A)
None
None
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
0.55A 3ik3B-2dq7X:
32.1
3ik3B-2dq7X:
44.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 GLU X  54
MET X  58
LEU X  66
VAL X  67
LEU X 137
ALA X 147
STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
0.81A 3ik3B-2dq7X:
32.1
3ik3B-2dq7X:
44.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 MET X  58
LEU X  66
VAL X  67
HIS X 128
LEU X 137
ALA X 147
None
None
None
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
0.74A 3ik3B-2dq7X:
32.1
3ik3B-2dq7X:
44.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A 184
GLU A 201
ILE A 208
VAL A 220
HIS A 281
LEU A 290
ALA A 319
None
0.69A 3ik3B-2eu9A:
21.3
3ik3B-2eu9A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
H8H  A 534 (-3.2A)
None
None
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
0.83A 3ik3B-2h8hA:
30.2
3ik3B-2h8hA:
27.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
0.64A 3ik3B-2hckA:
29.8
3ik3B-2hckA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 271
MET A 292
LEU A 300
VAL A 301
HIS A 362
LEU A 371
ALA A 381
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
0.80A 3ik3B-2hk5A:
26.9
3ik3B-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 269
GLU A 286
MET A 290
ILE A 293
LEU A 298
LEU A 370
ALA A 380
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
0.39A 3ik3B-2hz0A:
33.9
3ik3B-2hz0A:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 269
MET A 290
ILE A 293
LEU A 298
HIS A 361
LEU A 370
ALA A 380
GIN  A 600 (-3.1A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
0.62A 3ik3B-2hz0A:
33.9
3ik3B-2hz0A:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 GLU A 286
MET A 290
ILE A 293
LEU A 298
VAL A 299
LEU A 370
ALA A 380
ASP A 381
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
0.81A 3ik3B-2hz0A:
33.9
3ik3B-2hz0A:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 MET A 290
ILE A 293
LEU A 298
VAL A 299
HIS A 361
LEU A 370
ALA A 380
ASP A 381
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
0.75A 3ik3B-2hz0A:
33.9
3ik3B-2hz0A:
98.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF00373
(FERM_M)
PF07714
(Pkinase_Tyr)
5 ALA A 452
GLU A 471
MET A 475
HIS A 544
LEU A 553
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
0.58A 3ik3B-2j0jA:
32.5
3ik3B-2j0jA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  31
GLU A  51
VAL A  64
LEU A 134
ALA A 144
None
0.55A 3ik3B-2jgzA:
23.0
3ik3B-2jgzA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  31
VAL A  64
HIS A 125
LEU A 134
ALA A 144
None
0.39A 3ik3B-2jgzA:
23.0
3ik3B-2jgzA:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
10 ALA A 271
GLU A 288
MET A 292
LEU A 300
VAL A 301
HIS A 362
LEU A 371
ALA A 381
ASP A 382
PHE A 383
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.9A)
None
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
0.62A 3ik3B-2og8A:
32.0
3ik3B-2og8A:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 853
ILE A 902
HIS A 962
LEU A 971
ALA A 981
ASP A 982
PHE A 983
MR9  A 301 (-3.5A)
MR9  A 301 (-4.1A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
0.54A 3ik3B-2p4iA:
23.3
3ik3B-2p4iA:
38.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 515
GLU A 534
MET A 538
ILE A 541
HIS A 624
LEU A 633
ALA A 643
None
0.70A 3ik3B-2psqA:
31.8
3ik3B-2psqA:
33.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 215
LEU A 244
HIS A 319
LEU A 328
ALA A 338
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.4A)
None
0.50A 3ik3B-2qluA:
24.4
3ik3B-2qluA:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 749
LEU A 780
VAL A 781
HIS A 841
LEU A 850
GW7  A   1 (-3.3A)
None
GW7  A   1 ( 4.7A)
None
GW7  A   1 (-4.2A)
0.71A 3ik3B-2r4bA:
29.0
3ik3B-2r4bA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
5 ALA A 273
LEU A 302
HIS A 365
LEU A 374
ALA A 384
None
0.44A 3ik3B-2zv7A:
25.6
3ik3B-2zv7A:
45.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 515
MET A 538
HIS A 624
LEU A 633
ALA A 643
M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
0.55A 3ik3B-3b2tA:
25.6
3ik3B-3b2tA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 512
GLU A 531
HIS A 621
LEU A 630
ALA A 640
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
0.49A 3ik3B-3c4fA:
25.2
3ik3B-3c4fA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 512
MET A 535
HIS A 621
LEU A 630
ALA A 640
C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
0.49A 3ik3B-3c4fA:
25.2
3ik3B-3c4fA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 220
GLU A 236
MET A 240
LEU A 248
HIS A 312
LEU A 321
None
0.63A 3ik3B-3d7uA:
31.2
3ik3B-3d7uA:
44.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 GLU A 236
MET A 240
LEU A 248
VAL A 249
HIS A 312
LEU A 321
None
0.84A 3ik3B-3d7uA:
31.2
3ik3B-3d7uA:
44.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 ALA A 663
GLU A 682
MET A 686
VAL A 695
HIS A 756
ASP A 776
PHE A 777
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
0.76A 3ik3B-3dkoA:
30.9
3ik3B-3dkoA:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 ALA A 663
VAL A 695
ILE A 711
HIS A 756
LEU A 765
ASP A 776
PHE A 777
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
0.86A 3ik3B-3dkoA:
30.9
3ik3B-3dkoA:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 859
GLU A 878
HIS A1020
LEU A1029
ASP A1040
PHE A1041
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.8A)
None
None
8ST  A2001 ( 3.7A)
0.93A 3ik3B-3hngA:
33.0
3ik3B-3hngA:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
5 ALA A 665
GLU A 684
MET A 688
HIS A 758
LEU A 767
None
0.54A 3ik3B-3kulA:
25.8
3ik3B-3kulA:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  46
GLU A  66
VAL A  79
LEU A 156
ALA A 166
None
0.56A 3ik3B-3mi9A:
22.7
3ik3B-3mi9A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  46
VAL A  79
HIS A 147
LEU A 156
ALA A 166
None
0.50A 3ik3B-3mi9A:
22.7
3ik3B-3mi9A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN


(Cryptosporidium
parvum)
PF00069
(Pkinase)
5 ALA A  49
VAL A  82
HIS A 142
LEU A 151
ALA A 161
ADP  A 314 (-3.5A)
None
None
ADP  A 314 (-4.6A)
None
0.57A 3ik3B-3nizA:
22.6
3ik3B-3nizA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 109
GLU A 130
MET A 134
HIS A 203
LEU A 212
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
0.57A 3ik3B-3nuuA:
22.8
3ik3B-3nuuA:
26.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
5 ALA A 576
GLU A 596
MET A 600
HIS A 674
LEU A 683
STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
0.53A 3ik3B-3ppzA:
28.4
3ik3B-3ppzA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
5 ALA A 576
MET A 600
VAL A 609
HIS A 674
LEU A 683
STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
0.71A 3ik3B-3ppzA:
28.4
3ik3B-3ppzA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 443
MET A 464
LEU A 472
VAL A 473
HIS A 534
LEU A 543
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
None
None
PP2  A   1 (-4.6A)
0.68A 3ik3B-3sxsA:
31.3
3ik3B-3sxsA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 512
GLU A 531
MET A 535
HIS A 621
LEU A 630
ALA A 640
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
0.57A 3ik3B-3tt0A:
30.6
3ik3B-3tt0A:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 570
VAL A 601
HIS A 677
LEU A 686
ASP A 697
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
0.68A 3ik3B-3v5qA:
28.8
3ik3B-3v5qA:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 866
GLU A 885
HIS A1026
LEU A1035
ASP A1046
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
None
0.62A 3ik3B-3vidA:
30.4
3ik3B-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 866
GLU A 885
ILE A 892
HIS A1026
ASP A1046
4TT  A2001 (-3.5A)
None
None
None
None
0.64A 3ik3B-3vidA:
30.4
3ik3B-3vidA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  31
LEU A  62
VAL A  63
HIS A 123
LEU A 132
38R  A 350 (-3.4A)
None
38R  A 350 ( 4.9A)
None
38R  A 350 (-4.3A)
0.64A 3ik3B-3zduA:
22.0
3ik3B-3zduA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  31
GLU A  51
LEU A  63
VAL A  64
HIS A 124
LEU A 133
D15  A 500 (-3.4A)
None
None
None
None
D15  A 500 (-4.5A)
0.62A 3ik3B-4aguA:
22.5
3ik3B-4aguA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  63
GLU A  81
VAL A  94
ILE A 110
LEU A 164
ALA A 174
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-3.3A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
0.73A 3ik3B-4bc6A:
21.5
3ik3B-4bc6A:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  63
VAL A  94
ILE A 110
HIS A 155
LEU A 164
ALA A 174
XZN  A1317 (-3.5A)
XZN  A1317 (-4.4A)
XZN  A1317 (-3.3A)
None
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
0.72A 3ik3B-4bc6A:
21.5
3ik3B-4bc6A:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 653
GLU A 672
MET A 676
HIS A 764
LEU A 773
ALA A 783
ASP A 784
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
0.68A 3ik3B-4ckrA:
32.4
3ik3B-4ckrA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 MET A 676
HIS A 764
LEU A 773
ALA A 783
ASP A 784
PHE A 785
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
0.75A 3ik3B-4ckrA:
32.4
3ik3B-4ckrA:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 ALA A 684
GLU A 705
LEU A 720
LEU A 789
ALA A 799
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
0.61A 3ik3B-4crsA:
20.6
3ik3B-4crsA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 853
GLU A 871
HIS A 947
LEU A 956
ALA A 966
19S  A1201 (-3.3A)
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
0.48A 3ik3B-4hviA:
24.7
3ik3B-4hviA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 ALA A 293
LEU A 322
HIS A 384
LEU A 393
ALA A 403
0J9  A 601 (-3.3A)
None
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
0.27A 3ik3B-4k11A:
30.1
3ik3B-4k11A:
34.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 ALA A 293
LEU A 322
VAL A 323
HIS A 384
ALA A 403
0J9  A 601 (-3.3A)
None
None
None
0J9  A 601 (-3.5A)
0.70A 3ik3B-4k11A:
30.1
3ik3B-4k11A:
34.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 506
GLU A 525
MET A 529
ILE A 532
LEU A 624
ALA A 634
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.4A)
None
0.75A 3ik3B-4k33A:
25.7
3ik3B-4k33A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 506
ILE A 532
HIS A 615
LEU A 624
ALA A 634
ACP  A 801 (-3.3A)
None
None
ACP  A 801 (-4.4A)
None
0.59A 3ik3B-4k33A:
25.7
3ik3B-4k33A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
6 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 4.8A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
0.69A 3ik3B-4lggA:
29.6
3ik3B-4lggA:
46.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE


(Leishmania
donovani)
PF00069
(Pkinase)
5 GLU A  94
MET A  98
LEU A 106
HIS A 173
ASP A 193
046  A 401 (-3.7A)
046  A 401 (-3.5A)
046  A 401 ( 4.6A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
0.63A 3ik3B-4o2zA:
21.6
3ik3B-4o2zA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5)
5 ALA B 390
LEU B 417
HIS B 483
LEU B 492
ALA B 502
ACP  B 801 (-3.2A)
None
None
ACP  B 801 (-4.5A)
None
0.57A 3ik3B-4oavB:
16.6
3ik3B-4oavB:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5)
5 LEU B 417
VAL B 418
HIS B 483
LEU B 492
ALA B 502
None
None
None
ACP  B 801 (-4.5A)
None
0.70A 3ik3B-4oavB:
16.6
3ik3B-4oavB:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
0.42A 3ik3B-4rt7A:
35.0
3ik3B-4rt7A:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
0.44A 3ik3B-4tptA:
21.8
3ik3B-4tptA:
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
6 ALA A  35
LEU A  64
VAL A  65
HIS A 127
LEU A 136
ALA A 146
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.8A)
None
0.52A 3ik3B-4ueuA:
31.9
3ik3B-4ueuA:
63.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  61
VAL A  92
HIS A 153
LEU A 162
ALA A 172
ASP A 173
6UI  A 700 (-3.3A)
None
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
0.73A 3ik3B-4usfA:
24.4
3ik3B-4usfA:
29.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 501
GLU A 520
MET A 524
HIS A 610
LEU A 619
ALA A 629
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
0.54A 3ik3B-4xcuA:
25.7
3ik3B-4xcuA:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
no annotation 7 ALA B 288
MET B 309
ILE B 312
LEU B 317
HIS B 380
LEU B 389
ALA B 399
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
None
None
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
0.59A 3ik3B-4xeyB:
30.1
3ik3B-4xeyB:
92.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
0.48A 3ik3B-4xufA:
33.2
3ik3B-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLU A 661
HIS A 809
LEU A 818
ASP A 829
PHE A 830
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
0.65A 3ik3B-4xufA:
33.2
3ik3B-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLU A 661
VAL A 675
HIS A 809
LEU A 818
ASP A 829
P30  A1001 (-3.1A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
0.57A 3ik3B-4xufA:
33.2
3ik3B-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 512
GLU A 531
MET A 535
HIS A 621
LEU A 630
ALA A 640
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
0.52A 3ik3B-5a46A:
25.0
3ik3B-5a46A:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 625
GLU A 644
MET A 648
HIS A 816
LEU A 825
ASP A 836
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
0.51A 3ik3B-5grnA:
34.6
3ik3B-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 GLU A 644
MET A 648
VAL A 658
HIS A 816
LEU A 825
ASP A 836
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
0.70A 3ik3B-5grnA:
34.6
3ik3B-5grnA:
33.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN


(Drosophila
melanogaster)
PF00069
(Pkinase)
5 ALA A  41
GLU A  61
VAL A  74
LEU A 143
ALA A 156
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
0.59A 3ik3B-5hu3A:
12.5
3ik3B-5hu3A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN


(Drosophila
melanogaster)
PF00069
(Pkinase)
5 ALA A  41
VAL A  74
HIS A 134
LEU A 143
ALA A 156
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
0.42A 3ik3B-5hu3A:
12.5
3ik3B-5hu3A:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A  76
HIS A 136
LEU A 145
ALA A 155
ASP A 156
65U  A 301 (-4.7A)
65U  A 301 (-3.3A)
None
65U  A 301 ( 3.9A)
65U  A 301 (-4.7A)
0.70A 3ik3B-5hx6A:
21.6
3ik3B-5hx6A:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  43
GLU A  61
MET A  65
HIS A 134
LEU A 143
ALA A 153
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
0.70A 3ik3B-5j5tA:
21.5
3ik3B-5j5tA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 297
GLU A 315
MET A 319
HIS A 387
LEU A 396
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
0.69A 3ik3B-5kbrA:
21.5
3ik3B-5kbrA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
5 ALA A 909
GLU A 927
LEU A 939
VAL A 940
LEU A1016
ATP  A1200 (-3.5A)
None
None
None
ATP  A1200 (-4.6A)
0.71A 3ik3B-5lpyA:
22.2
3ik3B-5lpyA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
5 ALA A 909
LEU A 939
VAL A 940
HIS A1007
LEU A1016
ATP  A1200 (-3.5A)
None
None
None
ATP  A1200 (-4.6A)
0.57A 3ik3B-5lpyA:
22.2
3ik3B-5lpyA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
5 ALA A 909
LEU A 939
VAL A 940
HIS A1007
LEU A1016
ADP  A1200 (-3.5A)
None
None
None
ADP  A1200 (-4.7A)
0.58A 3ik3B-5lpzA:
22.2
3ik3B-5lpzA:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 119
GLU A 136
VAL A 157
HIS A 223
ALA A 540
W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
None
DMS  A 717 ( 4.5A)
0.67A 3ik3B-5myvA:
19.8
3ik3B-5myvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 GLU A 136
VAL A 157
HIS A 223
LEU A 232
ALA A 540
DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
None
None
DMS  A 717 ( 4.5A)
0.53A 3ik3B-5myvA:
19.8
3ik3B-5myvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7s FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE


(Acinetobacter
baumannii)
PF01116
(F_bP_aldolase)
6 ALA A  22
ILE A 192
LEU A 229
VAL A 230
LEU A  10
ALA A 189
None
1.32A 3ik3B-5u7sA:
undetectable
3ik3B-5u7sA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1


(Homo sapiens)
no annotation 5 ALA A 107
GLU A 124
VAL A 145
HIS A 211
ALA A 496
EMH  A 705 (-3.6A)
None
EMH  A 705 ( 4.9A)
None
EMH  A 705 ( 4.0A)
0.52A 3ik3B-5xv7A:
20.5
3ik3B-5xv7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1


(Homo sapiens)
no annotation 5 GLU A 124
VAL A 145
HIS A 211
LEU A 220
ALA A 496
None
EMH  A 705 ( 4.9A)
None
None
EMH  A 705 ( 4.0A)
0.62A 3ik3B-5xv7A:
20.5
3ik3B-5xv7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
no annotation 5 ALA A  54
VAL A  83
HIS A 144
LEU A 153
ALA A 163
ANP  A 501 ( 3.7A)
None
None
ANP  A 501 (-4.6A)
None
0.72A 3ik3B-6ao5A:
21.9
3ik3B-6ao5A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12


(Homo sapiens)
no annotation 6 ALA A 754
GLU A 774
VAL A 787
HIS A 857
LEU A 866
ALA A 876
CJM  A1102 (-3.1A)
None
None
None
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
0.56A 3ik3B-6b3eA:
23.3
3ik3B-6b3eA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 5 ALA A 192
VAL A 249
HIS A 310
LEU A 319
ALA A 329
BI9  A 501 (-3.3A)
None
None
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
0.53A 3ik3B-6bqlA:
21.6
3ik3B-6bqlA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1


(Homo sapiens)
no annotation 5 ALA A 155
VAL A 212
HIS A 273
LEU A 282
ALA A 292
H1N  A 501 (-3.4A)
H1N  A 501 (-4.9A)
None
H1N  A 501 (-4.8A)
H1N  A 501 ( 3.9A)
0.50A 3ik3B-6ccfA:
21.9
3ik3B-6ccfA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 5 ALA A 192
VAL A 249
HIS A 310
LEU A 319
ALA A 329
F6J  A 501 (-3.4A)
None
None
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
0.48A 3ik3B-6cmjA:
22.0
3ik3B-6cmjA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG


(Homo sapiens)
no annotation 5 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
0.49A 3ik3B-6cnhA:
21.2
3ik3B-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG


(Homo sapiens)
no annotation 5 GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
0.42A 3ik3B-6cnhA:
21.2
3ik3B-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4


(Homo sapiens)
no annotation 5 ALA A 211
LEU A 245
VAL A 246
HIS A 309
LEU A 318
CJT  A 502 (-3.4A)
None
None
None
CJT  A 502 (-4.7A)
0.62A 3ik3B-6f3dA:
23.0
3ik3B-6f3dA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-)
no annotation 5 ALA U  42
VAL U  75
HIS U 135
LEU U 144
ALA U 156
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
None
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
0.67A 3ik3B-6fdyU:
21.6
3ik3B-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2


(Homo sapiens)
no annotation 6 ALA A 191
GLU A 208
ILE A 215
VAL A 227
HIS A 288
LEU A 297
3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
None
None
0.79A 3ik3B-6fylA:
21.5
3ik3B-6fylA:
undetectable