SIMILAR PATTERNS OF AMINO ACIDS FOR 3IK3_B_0LIB2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
VAL A  64
HIS A 124
LEU A 133
ALA A 143
 None
 0.47A 3ik3B-1h4lA:
22.9		 3ik3B-1h4lA:
24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
MET A 240
LEU A 248
HIS A 312
LEU A 321
 None
 0.63A 3ik3B-1k9aA:
30.5		 3ik3B-1k9aA:
30.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLU A 236
MET A 240
LEU A 248
VAL A 249
HIS A 312
LEU A 321
 None
 0.84A 3ik3B-1k9aA:
30.5		 3ik3B-1k9aA:
30.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ALA A 288
GLU A 305
MET A 309
ILE A 312
LEU A 317
HIS A 380
LEU A 389
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.57A 3ik3B-1opkA:
34.6		 3ik3B-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLU A 305
MET A 309
LEU A 317
VAL A 318
HIS A 380
LEU A 389
 P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
None
P16  A   2 (-4.4A)
 0.67A 3ik3B-1opkA:
34.6		 3ik3B-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 621
GLU A 640
HIS A 790
LEU A 799
ASP A 810
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.84A 3ik3B-1t46A:
29.2		 3ik3B-1t46A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 621
GLU A 640
VAL A 654
HIS A 790
LEU A 799
ASP A 810
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.48A 3ik3B-1t46A:
29.2		 3ik3B-1t46A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 367
GLU A 386
MET A 390
HIS A 459
LEU A 468
 STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-4.5A)
 0.58A 3ik3B-1u59A:
31.3		 3ik3B-1u59A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA X  37
GLU X  54
MET X  58
LEU X  66
LEU X 137
ALA X 147
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.67A 3ik3B-2dq7X:
32.1		 3ik3B-2dq7X:
44.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA X  37
MET X  58
LEU X  66
HIS X 128
LEU X 137
ALA X 147
 STU  X 902 (-3.1A)
None
None
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.55A 3ik3B-2dq7X:
32.1		 3ik3B-2dq7X:
44.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU X  54
MET X  58
LEU X  66
VAL X  67
LEU X 137
ALA X 147
 STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.81A 3ik3B-2dq7X:
32.1		 3ik3B-2dq7X:
44.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET X  58
LEU X  66
VAL X  67
HIS X 128
LEU X 137
ALA X 147
 None
None
None
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.74A 3ik3B-2dq7X:
32.1		 3ik3B-2dq7X:
44.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 184
GLU A 201
ILE A 208
VAL A 220
HIS A 281
LEU A 290
ALA A 319
 None
 0.69A 3ik3B-2eu9A:
21.3		 3ik3B-2eu9A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 H8H  A 534 (-3.2A)
None
None
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.83A 3ik3B-2h8hA:
30.2		 3ik3B-2h8hA:
27.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.64A 3ik3B-2hckA:
29.8		 3ik3B-2hckA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
MET A 292
LEU A 300
VAL A 301
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.80A 3ik3B-2hk5A:
26.9		 3ik3B-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 269
GLU A 286
MET A 290
ILE A 293
LEU A 298
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.39A 3ik3B-2hz0A:
33.9		 3ik3B-2hz0A:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 269
MET A 290
ILE A 293
LEU A 298
HIS A 361
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.62A 3ik3B-2hz0A:
33.9		 3ik3B-2hz0A:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLU A 286
MET A 290
ILE A 293
LEU A 298
VAL A 299
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.81A 3ik3B-2hz0A:
33.9		 3ik3B-2hz0A:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 MET A 290
ILE A 293
LEU A 298
VAL A 299
HIS A 361
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.75A 3ik3B-2hz0A:
33.9		 3ik3B-2hz0A:
98.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 ALA A 452
GLU A 471
MET A 475
HIS A 544
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
 0.58A 3ik3B-2j0jA:
32.5		 3ik3B-2j0jA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
GLU A  51
VAL A  64
LEU A 134
ALA A 144
 None
 0.55A 3ik3B-2jgzA:
23.0		 3ik3B-2jgzA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
VAL A  64
HIS A 125
LEU A 134
ALA A 144
 None
 0.39A 3ik3B-2jgzA:
23.0		 3ik3B-2jgzA:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 271
GLU A 288
MET A 292
LEU A 300
VAL A 301
HIS A 362
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.9A)
None
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.62A 3ik3B-2og8A:
32.0		 3ik3B-2og8A:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
ILE A 902
HIS A 962
LEU A 971
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.5A)
MR9  A 301 (-4.1A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.54A 3ik3B-2p4iA:
23.3		 3ik3B-2p4iA:
38.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
GLU A 534
MET A 538
ILE A 541
HIS A 624
LEU A 633
ALA A 643
 None
 0.70A 3ik3B-2psqA:
31.8		 3ik3B-2psqA:
33.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 215
LEU A 244
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.4A)
None
 0.50A 3ik3B-2qluA:
24.4		 3ik3B-2qluA:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 749
LEU A 780
VAL A 781
HIS A 841
LEU A 850
 GW7  A   1 (-3.3A)
None
GW7  A   1 ( 4.7A)
None
GW7  A   1 (-4.2A)
 0.71A 3ik3B-2r4bA:
29.0		 3ik3B-2r4bA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 273
LEU A 302
HIS A 365
LEU A 374
ALA A 384
 None
 0.44A 3ik3B-2zv7A:
25.6		 3ik3B-2zv7A:
45.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 515
MET A 538
HIS A 624
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.55A 3ik3B-3b2tA:
25.6		 3ik3B-3b2tA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 512
GLU A 531
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.49A 3ik3B-3c4fA:
25.2		 3ik3B-3c4fA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 512
MET A 535
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.49A 3ik3B-3c4fA:
25.2		 3ik3B-3c4fA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
MET A 240
LEU A 248
HIS A 312
LEU A 321
 None
 0.63A 3ik3B-3d7uA:
31.2		 3ik3B-3d7uA:
44.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A 236
MET A 240
LEU A 248
VAL A 249
HIS A 312
LEU A 321
 None
 0.84A 3ik3B-3d7uA:
31.2		 3ik3B-3d7uA:
44.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 663
GLU A 682
MET A 686
VAL A 695
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.76A 3ik3B-3dkoA:
30.9		 3ik3B-3dkoA:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 663
VAL A 695
ILE A 711
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.86A 3ik3B-3dkoA:
30.9		 3ik3B-3dkoA:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 859
GLU A 878
HIS A1020
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.8A)
None
None
8ST  A2001 ( 3.7A)
 0.93A 3ik3B-3hngA:
33.0		 3ik3B-3hngA:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
GLU A 684
MET A 688
HIS A 758
LEU A 767
 None
 0.54A 3ik3B-3kulA:
25.8		 3ik3B-3kulA:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  46
GLU A  66
VAL A  79
LEU A 156
ALA A 166
 None
 0.56A 3ik3B-3mi9A:
22.7		 3ik3B-3mi9A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  46
VAL A  79
HIS A 147
LEU A 156
ALA A 166
 None
 0.50A 3ik3B-3mi9A:
22.7		 3ik3B-3mi9A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ALA A  49
VAL A  82
HIS A 142
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
None
None
ADP  A 314 (-4.6A)
None
 0.57A 3ik3B-3nizA:
22.6		 3ik3B-3nizA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 109
GLU A 130
MET A 134
HIS A 203
LEU A 212
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
 0.57A 3ik3B-3nuuA:
22.8		 3ik3B-3nuuA:
26.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 ALA A 576
GLU A 596
MET A 600
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
 0.53A 3ik3B-3ppzA:
28.4		 3ik3B-3ppzA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 ALA A 576
MET A 600
VAL A 609
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
 0.71A 3ik3B-3ppzA:
28.4		 3ik3B-3ppzA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 443
MET A 464
LEU A 472
VAL A 473
HIS A 534
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
None
None
PP2  A   1 (-4.6A)
 0.68A 3ik3B-3sxsA:
31.3		 3ik3B-3sxsA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
HIS A 621
LEU A 630
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.57A 3ik3B-3tt0A:
30.6		 3ik3B-3tt0A:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 570
VAL A 601
HIS A 677
LEU A 686
ASP A 697
 0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
 0.68A 3ik3B-3v5qA:
28.8		 3ik3B-3v5qA:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
GLU A 885
HIS A1026
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
None
 0.62A 3ik3B-3vidA:
30.4		 3ik3B-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
GLU A 885
ILE A 892
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
 0.64A 3ik3B-3vidA:
30.4		 3ik3B-3vidA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
LEU A  62
VAL A  63
HIS A 123
LEU A 132
 38R  A 350 (-3.4A)
None
38R  A 350 ( 4.9A)
None
38R  A 350 (-4.3A)
 0.64A 3ik3B-3zduA:
22.0		 3ik3B-3zduA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  31
GLU A  51
LEU A  63
VAL A  64
HIS A 124
LEU A 133
 D15  A 500 (-3.4A)
None
None
None
None
D15  A 500 (-4.5A)
 0.62A 3ik3B-4aguA:
22.5		 3ik3B-4aguA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  63
GLU A  81
VAL A  94
ILE A 110
LEU A 164
ALA A 174
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-3.3A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.73A 3ik3B-4bc6A:
21.5		 3ik3B-4bc6A:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  63
VAL A  94
ILE A 110
HIS A 155
LEU A 164
ALA A 174
 XZN  A1317 (-3.5A)
XZN  A1317 (-4.4A)
XZN  A1317 (-3.3A)
None
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.72A 3ik3B-4bc6A:
21.5		 3ik3B-4bc6A:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
GLU A 672
MET A 676
HIS A 764
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.68A 3ik3B-4ckrA:
32.4		 3ik3B-4ckrA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 676
HIS A 764
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.75A 3ik3B-4ckrA:
32.4		 3ik3B-4ckrA:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 684
GLU A 705
LEU A 720
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.61A 3ik3B-4crsA:
20.6		 3ik3B-4crsA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 853
GLU A 871
HIS A 947
LEU A 956
ALA A 966
 19S  A1201 (-3.3A)
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.48A 3ik3B-4hviA:
24.7		 3ik3B-4hviA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
LEU A 322
HIS A 384
LEU A 393
ALA A 403
 0J9  A 601 (-3.3A)
None
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.27A 3ik3B-4k11A:
30.1		 3ik3B-4k11A:
34.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
LEU A 322
VAL A 323
HIS A 384
ALA A 403
 0J9  A 601 (-3.3A)
None
None
None
0J9  A 601 (-3.5A)
 0.70A 3ik3B-4k11A:
30.1		 3ik3B-4k11A:
34.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 506
GLU A 525
MET A 529
ILE A 532
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.4A)
None
 0.75A 3ik3B-4k33A:
25.7		 3ik3B-4k33A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 506
ILE A 532
HIS A 615
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
None
None
ACP  A 801 (-4.4A)
None
 0.59A 3ik3B-4k33A:
25.7		 3ik3B-4k33A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 4.8A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.69A 3ik3B-4lggA:
29.6		 3ik3B-4lggA:
46.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 GLU A  94
MET A  98
LEU A 106
HIS A 173
ASP A 193
 046  A 401 (-3.7A)
046  A 401 (-3.5A)
046  A 401 ( 4.6A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.63A 3ik3B-4o2zA:
21.6		 3ik3B-4o2zA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA B 390
LEU B 417
HIS B 483
LEU B 492
ALA B 502
 ACP  B 801 (-3.2A)
None
None
ACP  B 801 (-4.5A)
None
 0.57A 3ik3B-4oavB:
16.6		 3ik3B-4oavB:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU B 417
VAL B 418
HIS B 483
LEU B 492
ALA B 502
 None
None
None
ACP  B 801 (-4.5A)
None
 0.70A 3ik3B-4oavB:
16.6		 3ik3B-4oavB:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
 0.42A 3ik3B-4rt7A:
35.0		 3ik3B-4rt7A:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.44A 3ik3B-4tptA:
21.8		 3ik3B-4tptA:
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
LEU A  64
VAL A  65
HIS A 127
LEU A 136
ALA A 146
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.52A 3ik3B-4ueuA:
31.9		 3ik3B-4ueuA:
63.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  61
VAL A  92
HIS A 153
LEU A 162
ALA A 172
ASP A 173
 6UI  A 700 (-3.3A)
None
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
 0.73A 3ik3B-4usfA:
24.4		 3ik3B-4usfA:
29.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 501
GLU A 520
MET A 524
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.54A 3ik3B-4xcuA:
25.7		 3ik3B-4xcuA:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 ALA B 288
MET B 309
ILE B 312
LEU B 317
HIS B 380
LEU B 389
ALA B 399
 1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
None
None
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.59A 3ik3B-4xeyB:
30.1		 3ik3B-4xeyB:
92.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
 0.48A 3ik3B-4xufA:
33.2		 3ik3B-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLU A 661
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.65A 3ik3B-4xufA:
33.2		 3ik3B-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLU A 661
VAL A 675
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.1A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
 0.57A 3ik3B-4xufA:
33.2		 3ik3B-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.52A 3ik3B-5a46A:
25.0		 3ik3B-5a46A:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
GLU A 644
MET A 648
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.51A 3ik3B-5grnA:
34.6		 3ik3B-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A 644
MET A 648
VAL A 658
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.70A 3ik3B-5grnA:
34.6		 3ik3B-5grnA:
33.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 ALA A  41
GLU A  61
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.59A 3ik3B-5hu3A:
12.5		 3ik3B-5hu3A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 ALA A  41
VAL A  74
HIS A 134
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.42A 3ik3B-5hu3A:
12.5		 3ik3B-5hu3A:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A  76
HIS A 136
LEU A 145
ALA A 155
ASP A 156
 65U  A 301 (-4.7A)
65U  A 301 (-3.3A)
None
65U  A 301 ( 3.9A)
65U  A 301 (-4.7A)
 0.70A 3ik3B-5hx6A:
21.6		 3ik3B-5hx6A:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
GLU A  61
MET A  65
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.70A 3ik3B-5j5tA:
21.5		 3ik3B-5j5tA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 297
GLU A 315
MET A 319
HIS A 387
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
 0.69A 3ik3B-5kbrA:
21.5		 3ik3B-5kbrA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ALA A 909
GLU A 927
LEU A 939
VAL A 940
LEU A1016
 ATP  A1200 (-3.5A)
None
None
None
ATP  A1200 (-4.6A)
 0.71A 3ik3B-5lpyA:
22.2		 3ik3B-5lpyA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ALA A 909
LEU A 939
VAL A 940
HIS A1007
LEU A1016
 ATP  A1200 (-3.5A)
None
None
None
ATP  A1200 (-4.6A)
 0.57A 3ik3B-5lpyA:
22.2		 3ik3B-5lpyA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ALA A 909
LEU A 939
VAL A 940
HIS A1007
LEU A1016
 ADP  A1200 (-3.5A)
None
None
None
ADP  A1200 (-4.7A)
 0.58A 3ik3B-5lpzA:
22.2		 3ik3B-5lpzA:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 119
GLU A 136
VAL A 157
HIS A 223
ALA A 540
 W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
None
DMS  A 717 ( 4.5A)
 0.67A 3ik3B-5myvA:
19.8		 3ik3B-5myvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLU A 136
VAL A 157
HIS A 223
LEU A 232
ALA A 540
 DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
None
None
DMS  A 717 ( 4.5A)
 0.53A 3ik3B-5myvA:
19.8		 3ik3B-5myvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7s FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Acinetobacter
baumannii) 		PF01116
(F_bP_aldolase) 		6 ALA A  22
ILE A 192
LEU A 229
VAL A 230
LEU A  10
ALA A 189
 None
 1.32A 3ik3B-5u7sA:
undetectable		 3ik3B-5u7sA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 ALA A 107
GLU A 124
VAL A 145
HIS A 211
ALA A 496
 EMH  A 705 (-3.6A)
None
EMH  A 705 ( 4.9A)
None
EMH  A 705 ( 4.0A)
 0.52A 3ik3B-5xv7A:
20.5		 3ik3B-5xv7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 GLU A 124
VAL A 145
HIS A 211
LEU A 220
ALA A 496
 None
EMH  A 705 ( 4.9A)
None
None
EMH  A 705 ( 4.0A)
 0.62A 3ik3B-5xv7A:
20.5		 3ik3B-5xv7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 ALA A  54
VAL A  83
HIS A 144
LEU A 153
ALA A 163
 ANP  A 501 ( 3.7A)
None
None
ANP  A 501 (-4.6A)
None
 0.72A 3ik3B-6ao5A:
21.9		 3ik3B-6ao5A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 6 ALA A 754
GLU A 774
VAL A 787
HIS A 857
LEU A 866
ALA A 876
 CJM  A1102 (-3.1A)
None
None
None
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.56A 3ik3B-6b3eA:
23.3		 3ik3B-6b3eA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 ALA A 192
VAL A 249
HIS A 310
LEU A 319
ALA A 329
 BI9  A 501 (-3.3A)
None
None
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
 0.53A 3ik3B-6bqlA:
21.6		 3ik3B-6bqlA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 5 ALA A 155
VAL A 212
HIS A 273
LEU A 282
ALA A 292
 H1N  A 501 (-3.4A)
H1N  A 501 (-4.9A)
None
H1N  A 501 (-4.8A)
H1N  A 501 ( 3.9A)
 0.50A 3ik3B-6ccfA:
21.9		 3ik3B-6ccfA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 ALA A 192
VAL A 249
HIS A 310
LEU A 319
ALA A 329
 F6J  A 501 (-3.4A)
None
None
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
 0.48A 3ik3B-6cmjA:
22.0		 3ik3B-6cmjA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
 0.49A 3ik3B-6cnhA:
21.2		 3ik3B-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.42A 3ik3B-6cnhA:
21.2		 3ik3B-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 5 ALA A 211
LEU A 245
VAL A 246
HIS A 309
LEU A 318
 CJT  A 502 (-3.4A)
None
None
None
CJT  A 502 (-4.7A)
 0.62A 3ik3B-6f3dA:
23.0		 3ik3B-6f3dA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 5 ALA U  42
VAL U  75
HIS U 135
LEU U 144
ALA U 156
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
None
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.67A 3ik3B-6fdyU:
21.6		 3ik3B-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 ALA A 191
GLU A 208
ILE A 215
VAL A 227
HIS A 288
LEU A 297
 3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
None
None
 0.79A 3ik3B-6fylA:
21.5		 3ik3B-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akc ASPARTATE
AMINOTRANSFERASE

(Gallus gallus) 		PF00155
(Aminotran_1_2) 		4 LEU A 187
TYR A 220
ILE A 248
MET A 223
 None
 1.29A 3ik3B-1akcA:
undetectable		 3ik3B-1akcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akc ASPARTATE
AMINOTRANSFERASE

(Gallus gallus) 		PF00155
(Aminotran_1_2) 		4 LEU A 187
TYR A 220
MET A 223
ARG A 275
 None
 1.08A 3ik3B-1akcA:
undetectable		 3ik3B-1akcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		4 LEU A 101
VAL A  61
ILE A 167
ARG A  50
 None
 1.30A 3ik3B-1fuuA:
undetectable		 3ik3B-1fuuA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 191
TYR A 230
VAL A 265
ILE A 288
 None
 1.06A 3ik3B-1k86A:
undetectable		 3ik3B-1k86A:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 267
LYS A 290
VAL A 308
ILE A 332
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
 0.50A 3ik3B-1opkA:
34.6		 3ik3B-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 267
VAL A 308
ILE A 332
MET A 337
 P16  A   2 ( 4.2A)
None
P16  A   2 (-4.1A)
None
 0.35A 3ik3B-1opkA:
34.6		 3ik3B-1opkA:
57.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orp ENDONUCLEASE III

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 TYR A   9
VAL A 161
ILE A 168
ARG A 144
 None
 1.24A 3ik3B-1orpA:
undetectable		 3ik3B-1orpA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkr AZURIN-I

(Achromobacter
xylosoxidans) 		PF00127
(Copper-bind) 		4 LEU A  68
TYR A  72
VAL A  31
MET A  44
 None
 1.01A 3ik3B-1rkrA:
undetectable		 3ik3B-1rkrA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq4 GLYOXYLATE-INDUCED
PROTEIN

(Pseudomonas
aeruginosa) 		PF07883
(Cupin_2) 		4 LEU A 262
TYR A 260
VAL A  37
ILE A  57
 SCN  A 302 ( 4.5A)
None
None
None
 1.28A 3ik3B-1sq4A:
undetectable		 3ik3B-1sq4A:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
LYS A 623
VAL A 643
ARG A 791
 STI  A   3 ( 3.8A)
STI  A   3 (-3.7A)
None
None
 1.09A 3ik3B-1t46A:
29.2		 3ik3B-1t46A:
35.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi3 THIAMINE PHOSPHATE
PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF02581
(TMP-TENI) 		4 LEU A 114
VAL A  82
ILE A  91
ARG A  38
 None
 1.33A 3ik3B-1xi3A:
undetectable		 3ik3B-1xi3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 LEU A 124
TYR A 123
VAL A 226
MET A 245
 None
 1.20A 3ik3B-1xx4A:
undetectable		 3ik3B-1xx4A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10) 		4 TYR A 670
VAL A 701
ILE A 715
ARG A 655
 None
 1.26A 3ik3B-1xyzA:
undetectable		 3ik3B-1xyzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.08A 3ik3B-1ycnA:
undetectable		 3ik3B-1ycnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		4 LEU U 468
VAL U 389
ILE U 463
ARG U 351
 None
 1.14A 3ik3B-1z5xU:
undetectable		 3ik3B-1z5xU:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A  85
VAL A 398
ILE A 405
ARG A 205
 None
 1.05A 3ik3B-2bmaA:
undetectable		 3ik3B-2bmaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ciy CHLOROPEROXIDASE

(Leptoxyphium
fumago) 		PF01328
(Peroxidase_2) 		4 LEU A 196
VAL A 141
ILE A 207
ARG A 157
 None
MAN  A 751 ( 4.1A)
None
None
 1.21A 3ik3B-2ciyA:
undetectable		 3ik3B-2ciyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 LEU A 284
TYR A 279
VAL A 241
ILE A 205
 None
 1.29A 3ik3B-2dbyA:
undetectable		 3ik3B-2dbyA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
ILE X  80
MET X  85
ARG X 129
 STU  X 902 (-3.8A)
None
None
PTR  X 160 ( 3.4A)
 0.83A 3ik3B-2dq7X:
32.1		 3ik3B-2dq7X:
44.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
LYS A 186
VAL A 204
ILE A 234
 None
 0.66A 3ik3B-2eu9A:
21.3		 3ik3B-2eu9A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A  19
ILE A  91
MET A  96
ARG A 136
 ADP  A 500 (-4.3A)
None
None
None
 0.68A 3ik3B-2f9gA:
21.4		 3ik3B-2f9gA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A  19
LYS A  42
ILE A  91
ARG A 136
 ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
 0.79A 3ik3B-2f9gA:
21.4		 3ik3B-2f9gA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 LEU A 238
VAL A  34
ILE A 136
ARG A  49
 None
 1.10A 3ik3B-2fpqA:
undetectable		 3ik3B-2fpqA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.85A 3ik3B-2hckA:
29.8		 3ik3B-2hckA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
LYS A 273
VAL A 291
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
 0.58A 3ik3B-2hk5A:
26.8		 3ik3B-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.9A)
None
 0.72A 3ik3B-2hk5A:
26.8		 3ik3B-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 248
LYS A 271
VAL A 289
ILE A 313
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.8A)
 0.73A 3ik3B-2hz0A:
33.9		 3ik3B-2hz0A:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 248
VAL A 289
ILE A 313
MET A 318
 GIN  A 600 ( 4.6A)
None
GIN  A 600 (-3.8A)
None
 0.31A 3ik3B-2hz0A:
33.9		 3ik3B-2hz0A:
98.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipp CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU B 181
VAL B 246
MET B 195
ARG B 235
 None
 1.17A 3ik3B-2ippB:
undetectable		 3ik3B-2ippB:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
ILE A 314
MET A 319
ARG A 363
 None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
None
 0.81A 3ik3B-2og8A:
32.0		 3ik3B-2og8A:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
LYS A 273
ILE A 314
ARG A 363
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
None
 1.19A 3ik3B-2og8A:
32.0		 3ik3B-2og8A:
44.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 LEU A  52
TYR A  50
ILE A  11
ARG A 106
 None
 1.27A 3ik3B-2okxA:
undetectable		 3ik3B-2okxA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU X  70
LYS X  93
ILE X 136
ARG X 185
 F10  X 401 (-3.9A)
F10  X 401 (-4.3A)
None
None
 1.04A 3ik3B-2p3gX:
17.5		 3ik3B-2p3gX:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 LEU A  25
LYS A  48
MET A 106
ARG A 148
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.2A)
None
None
 1.20A 3ik3B-2phkA:
21.7		 3ik3B-2phkA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		4 LEU A 158
TYR A  67
VAL A 232
ILE A 196
 None
 1.23A 3ik3B-2qptA:
undetectable		 3ik3B-2qptA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		4 LEU A  80
VAL A 107
ILE A 146
ARG A  99
 None
 1.33A 3ik3B-2v1uA:
undetectable		 3ik3B-2v1uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		4 LEU A 237
TYR A 272
VAL A  73
ILE A  26
 None
 1.19A 3ik3B-2xsbA:
undetectable		 3ik3B-2xsbA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl5 58 KD CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 LEU A 238
VAL A 277
ILE A 442
MET A 422
 None
 1.32A 3ik3B-2zl5A:
undetectable		 3ik3B-2zl5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh2 ACETOACETATE
DECARBOXYLASE

(Clostridium
acetobutylicum) 		PF06314
(ADC) 		4 LYS A 169
ILE A 184
MET A  96
ARG A  21
 None
 1.32A 3ik3B-3bh2A:
undetectable		 3ik3B-3bh2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN-TYPE

(Toxoplasma
gondii) 		PF00160
(Pro_isomerase) 		4 LEU A  64
VAL A 145
ILE A  57
ARG A  10
 SO4  A 205 (-4.3A)
None
None
None
 1.02A 3ik3B-3bo7A:
undetectable		 3ik3B-3bo7A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 LEU A 298
VAL A 335
ILE A 332
ARG A 142
 None
 1.30A 3ik3B-3cq5A:
undetectable		 3ik3B-3cq5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		4 LEU A  12
VAL A 125
ILE A 112
ARG A 152
 None
 1.31A 3ik3B-3e96A:
undetectable		 3ik3B-3e96A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD

(Escherichia
coli) 		PF03958
(Secretin_N) 		4 LEU A  60
TYR A  65
LYS A  76
ILE A  30
 None
 1.15A 3ik3B-3ezjA:
undetectable		 3ik3B-3ezjA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
ILE A 127
MET A 132
 STU  A   1 (-3.8A)
STU  A   1 ( 4.2A)
None
None
 0.54A 3ik3B-3fmeA:
17.3		 3ik3B-3fmeA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		4 LEU A 402
TYR A 190
ILE A 410
ARG A 201
 None
 1.26A 3ik3B-3hd6A:
undetectable		 3ik3B-3hd6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9m CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU A 181
VAL A 246
MET A 195
ARG A 235
 None
 1.17A 3ik3B-3k9mA:
undetectable		 3ik3B-3k9mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		4 LEU A 160
VAL A  49
ILE A   6
MET A 149
 None
None
None
AMP  A 509 (-3.0A)
 1.05A 3ik3B-3kd6A:
undetectable		 3ik3B-3kd6A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl0 GLUCURONOXYLANASE
XYNC

(Bacillus
subtilis) 		PF17189
(Glyco_hydro_30C) 		4 LEU A 362
TYR A 288
VAL A 230
ILE A 253
 None
 1.11A 3ik3B-3kl0A:
undetectable		 3ik3B-3kl0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile) 		PF00491
(Arginase) 		4 LEU A  54
VAL A 103
ILE A  70
MET A  47
 None
 1.25A 3ik3B-3lhlA:
undetectable		 3ik3B-3lhlA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 LEU A 680
LYS A 702
ILE A 743
ARG A 796
 ADP  A2101 ( 4.1A)
ADP  A2101 (-2.7A)
None
TPO  A 844 ( 3.0A)
 0.99A 3ik3B-3lj0A:
21.2		 3ik3B-3lj0A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg6 PROTEASOME COMPONENT
C11

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 LEU J 138
TYR J 124
ILE J   3
ARG J  84
 None
 1.25A 3ik3B-3mg6J:
undetectable		 3ik3B-3mg6J:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 LEU A 461
TYR A 462
VAL A 363
ARG A 476
 None
 1.18A 3ik3B-3nzuA:
2.7		 3ik3B-3nzuA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD

(Escherichia
coli) 		PF03958
(Secretin_N) 		4 LEU D  60
TYR D  65
LYS D  76
ILE D  30
 None
 1.07A 3ik3B-3ossD:
undetectable		 3ik3B-3ossD:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  50
LYS A  73
ILE A 116
ARG A 165
 I85  A 350 (-3.7A)
I85  A 350 (-2.8A)
None
None
 0.82A 3ik3B-3sheA:
18.3		 3ik3B-3sheA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 LEU X 246
VAL X 186
ILE X 236
ARG X 181
 None
 1.16A 3ik3B-3ss7X:
undetectable		 3ik3B-3ss7X:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5) 		PF00544
(Pec_lyase_C) 		4 TYR A   7
ILE A 134
MET A 218
ARG A 160
 None
None
None
SO4  A 907 (-3.3A)
 1.10A 3ik3B-3vmwA:
undetectable		 3ik3B-3vmwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
ILE A 127
MET A 132
 None
ANK  A 401 (-2.4A)
None
None
 0.76A 3ik3B-3vn9A:
21.9		 3ik3B-3vn9A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-4

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 LEU K 143
TYR K 129
ILE K   3
ARG K  84
 None
 1.25A 3ik3B-3wxrK:
undetectable		 3ik3B-3wxrK:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 TYR A 357
VAL A 450
ILE A 478
MET A 398
 GOL  A1888 (-3.9A)
None
None
None
 1.20A 3ik3B-4aioA:
undetectable		 3ik3B-4aioA:
16.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
LYS A 655
MET A 704
ARG A 765
 None
DI1  A1000 (-3.9A)
None
None
 0.94A 3ik3B-4ckrA:
32.4		 3ik3B-4ckrA:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		4 LEU A 396
VAL A 123
ILE A 117
ARG A 231
 None
 1.28A 3ik3B-4e4jA:
undetectable		 3ik3B-4e4jA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 280
VAL A 244
ILE A 336
ARG A 372
 None
 1.13A 3ik3B-4eclA:
undetectable		 3ik3B-4eclA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		4 TYR A  58
VAL A 363
ILE A 359
ARG A 565
 None
 1.20A 3ik3B-4hhrA:
undetectable		 3ik3B-4hhrA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		4 LEU A 182
TYR A 187
VAL A 250
ILE A 253
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
None
None
 1.32A 3ik3B-4ineA:
2.3		 3ik3B-4ineA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		4 LEU A1163
ILE A 989
MET A1158
ARG A 931
 None
 1.32A 3ik3B-4k6jA:
undetectable		 3ik3B-4k6jA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
VAL A 313
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
 0.81A 3ik3B-4lggA:
29.6		 3ik3B-4lggA:
46.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
VAL A 313
ILE A 336
MET A 341
 VGG  A 601 (-3.2A)
None
VGG  A 601 (-4.2A)
None
 0.90A 3ik3B-4lggA:
29.6		 3ik3B-4lggA:
46.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN

(Helicobacter
pylori) 		PF01497
(Peripla_BP_2) 		4 LEU A 324
TYR A 318
MET A  66
ARG A 183
 None
 1.30A 3ik3B-4ls3A:
undetectable		 3ik3B-4ls3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mru SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 LEU A  57
VAL A 523
ILE A 151
ARG A 459
 None
 1.00A 3ik3B-4mruA:
undetectable		 3ik3B-4mruA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 LEU A 304
VAL A 447
ILE A 429
ARG A 373
 None
 1.17A 3ik3B-4n2cA:
undetectable		 3ik3B-4n2cA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3w CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		4 LEU A1275
TYR A1204
VAL A1295
ARG A1288
 None
 1.22A 3ik3B-4n3wA:
undetectable		 3ik3B-4n3wA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		4 LEU A 197
ILE A 284
MET A 229
ARG A  20
 None
None
CSO  A 255 ( 4.0A)
None
 1.16A 3ik3B-4q2hA:
undetectable		 3ik3B-4q2hA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdk MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF07109
(Mg-por_mtran_C) 		4 LEU A 155
TYR A 128
VAL A  48
ILE A 161
 None
 1.32A 3ik3B-4qdkA:
undetectable		 3ik3B-4qdkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudarthrobacter
chlorophenolicus) 		PF01547
(SBP_bac_1) 		4 LEU A 324
ILE A 314
MET A 226
ARG A 178
 None
 1.21A 3ik3B-4r2fA:
undetectable		 3ik3B-4r2fA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		4 LEU A 262
VAL A 160
ILE A 396
ARG A 248
 None
 1.24A 3ik3B-4tvmA:
undetectable		 3ik3B-4tvmA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 LEU A 490
TYR A 487
VAL A 471
MET A 439
 None
 1.32A 3ik3B-4uplA:
undetectable		 3ik3B-4uplA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0j ACYL-[ACYL-CARRIER-P
ROTEIN] DESATURASE,
CHLOROPLASTIC

(Ricinus
communis) 		PF03405
(FA_desaturase_2) 		4 VAL A 305
ILE A 190
MET A 265
ARG A 329
 None
 0.79A 3ik3B-4v0jA:
undetectable		 3ik3B-4v0jA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 TYR A 109
VAL A 288
ILE A 428
MET A 367
 None
 1.21A 3ik3B-4v20A:
undetectable		 3ik3B-4v20A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv4 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 10
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8

(Homo sapiens) 		PF03540
(TFIID_30kDa)
PF07524
(Bromo_TP) 		4 LEU A 123
TYR A 126
VAL B  39
ILE A 130
 None
 1.31A 3ik3B-4wv4A:
undetectable		 3ik3B-4wv4A:
17.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LEU B 267
VAL B 308
ILE B 332
MET B 337
 1N1  B 601 (-3.7A)
None
1N1  B 601 (-4.1A)
None
 0.63A 3ik3B-4xeyB:
30.1		 3ik3B-4xeyB:
92.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A  33
VAL A 540
ILE A 273
ARG A 559
 None
 1.07A 3ik3B-4ynuA:
undetectable		 3ik3B-4ynuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 LEU A 736
VAL A 768
ILE A 759
ARG A 728
 None
None
None
BCO  A1103 (-3.6A)
 1.19A 3ik3B-5cjuA:
undetectable		 3ik3B-5cjuA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d76 PUTATIVE PHAGE LYSIN

(Streptococcus
phage phi7917) 		PF05257
(CHAP)
PF08460
(SH3_5) 		4 TYR A 237
VAL A 214
ILE A 206
MET A  36
 None
 1.16A 3ik3B-5d76A:
undetectable		 3ik3B-5d76A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlk TQAA

(Penicillium
aethiopicum) 		PF00668
(Condensation) 		4 LEU A 472
VAL A 274
ILE A 461
MET A 348
 EDO  A 505 ( 4.0A)
None
None
None
 1.02A 3ik3B-5dlkA:
undetectable		 3ik3B-5dlkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 LEU A 514
VAL A 457
ILE A 427
ARG A 419
 None
 1.27A 3ik3B-5dotA:
undetectable		 3ik3B-5dotA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		4 LEU A 154
VAL A 337
MET A 224
ARG A 331
 5U5  A 401 (-4.8A)
None
None
None
 1.21A 3ik3B-5eykA:
17.1		 3ik3B-5eykA:
24.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 599
LYS A 627
ILE A 672
ARG A 817
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
None
 1.05A 3ik3B-5grnA:
34.6		 3ik3B-5grnA:
33.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 275
TYR A 209
VAL A 220
ILE A 142
 None
 1.31A 3ik3B-5h12A:
undetectable		 3ik3B-5h12A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h55 MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Kluyveromyces
lactis) 		no annotation 4 LEU A 134
VAL A  16
ILE A 146
ARG A  11
 None
 1.27A 3ik3B-5h55A:
undetectable		 3ik3B-5h55A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5c MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Kluyveromyces
lactis) 		no annotation 4 LEU A 134
VAL A  16
ILE A 146
ARG A  11
 None
 1.28A 3ik3B-5h5cA:
undetectable		 3ik3B-5h5cA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		4 LEU A 247
VAL A  55
ILE A 122
ARG A  50
 None
 1.31A 3ik3B-5ijlA:
undetectable		 3ik3B-5ijlA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		4 LEU A1202
TYR A1179
ILE A1106
ARG A1126
 SAM  A1304 ( 4.7A)
SAM  A1304 (-4.1A)
None
None
 1.25A 3ik3B-5lsuA:
undetectable		 3ik3B-5lsuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  17
LYS A  40
ILE A  90
ARG A 137
 G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.8A)
None
 0.92A 3ik3B-5u94A:
18.0		 3ik3B-5u94A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 4 TYR B 183
VAL B 244
ILE B 223
ARG B 196
 None
None
None
SO4  B 304 ( 3.1A)
 1.17A 3ik3B-5uuoB:
undetectable		 3ik3B-5uuoB:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 4 LEU A 150
VAL A  83
ILE A 116
MET A 245
 None
 1.32A 3ik3B-6b5fA:
undetectable		 3ik3B-6b5fA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bc5 AAC 3-VI PROTEIN

(Enterobacter
cloacae) 		no annotation 4 TYR A 190
VAL A 254
ILE A 175
ARG A 251
 None
 1.19A 3ik3B-6bc5A:
undetectable		 3ik3B-6bc5A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdg 4-HYDROXYBENZOYL-COA
THIOESTERASE

(Staphylococcus
aureus) 		no annotation 4 LEU A  41
VAL A  74
ILE A   5
ARG A  11
 None
 1.22A 3ik3B-6fdgA:
undetectable		 3ik3B-6fdgA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 LEU A 169
LYS A 193
VAL A 211
ILE A 241
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.0A)
None
None
 0.57A 3ik3B-6fylA:
21.6		 3ik3B-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.64A 3ik3B-6fyoA:
21.2		 3ik3B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.62A 3ik3B-6fyvA:
21.5		 3ik3B-6fyvA:
undetectable