SIMILAR PATTERNS OF AMINO ACIDS FOR 3IJX_H_HCZH800_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fgg GLUCURONYLTRANSFERAS
E I

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 PRO A 250
SER A 246
LEU A 285
SER A 286
 None
 1.49A 3ijxH-1fggA:
undetectable		 3ijxH-1fggA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 PRO A 297
SER A 222
LEU A 158
SER A 300
 None
 1.15A 3ijxH-1flcA:
undetectable		 3ijxH-1flcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iz6 INITIATION FACTOR 5A

(Pyrococcus
horikoshii) 		PF01287
(eIF-5a)
PF08207
(EFP_N) 		4 LYS A  60
PRO A  61
SER A  40
SER A  10
 None
 1.08A 3ijxH-1iz6A:
undetectable		 3ijxH-1iz6A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 PRO A1296
SER A1278
LEU A1319
SER A1318
 None
 1.27A 3ijxH-1jl5A:
0.0		 3ijxH-1jl5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm7 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN

(Homo sapiens) 		PF00097
(zf-C3HC4) 		4 LYS A  45
SER A  80
LEU A  73
SER A  36
 None
 1.43A 3ijxH-1jm7A:
undetectable		 3ijxH-1jm7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PRO A 169
SER A 166
LEU A 173
SER A 172
 None
 1.38A 3ijxH-1k4qA:
0.0		 3ijxH-1k4qA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwi PROTEGRIN-3
PRECURSOR

(Sus scrofa) 		PF00666
(Cathelicidins) 		4 LYS A  74
PRO A  75
SER A  77
LEU A 113
 None
 1.23A 3ijxH-1kwiA:
undetectable		 3ijxH-1kwiA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 LYS A 839
SER A 644
LEU A 824
SER A 826
 None
 1.24A 3ijxH-1n7rA:
undetectable		 3ijxH-1n7rA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		4 PRO A 727
SER A 623
LEU A 630
SER A 563
 None
 1.34A 3ijxH-1nphA:
0.0		 3ijxH-1nphA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 LYS A 505
SER A 541
LEU A 507
SER A 481
 None
 1.19A 3ijxH-1nugA:
undetectable		 3ijxH-1nugA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanopyrus
kandleri) 		PF02289
(MCH) 		4 PRO A 111
SER A 109
LEU A  60
SER A  88
 None
 1.29A 3ijxH-1qlmA:
undetectable		 3ijxH-1qlmA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus A) 		PF00073
(Rhv) 		4 PRO 2 226
SER 2  75
LEU 2 180
SER 2 171
 None
 1.41A 3ijxH-1r1a2:
undetectable		 3ijxH-1r1a2:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 PRO A 756
SER A 793
LEU A 802
SER A 803
 None
 1.29A 3ijxH-1sojA:
undetectable		 3ijxH-1sojA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00180
(Iso_dh) 		4 PRO A 106
SER A 261
LEU A 130
SER A 249
 None
 1.44A 3ijxH-1vlcA:
undetectable		 3ijxH-1vlcA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 PRO A 490
SER A 502
LEU A 335
SER A 337
 GDP  A1002 (-3.9A)
None
None
None
 1.29A 3ijxH-1xjeA:
undetectable		 3ijxH-1xjeA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		4 PRO A 232
SER A 230
LEU A 263
SER A 262
 None
B12  A   0 (-3.2A)
None
None
 1.35A 3ijxH-2bb6A:
undetectable		 3ijxH-2bb6A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2doc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3) 		4 PRO A 112
SER A 114
LEU A  29
SER A  30
 None
 1.41A 3ijxH-2docA:
undetectable		 3ijxH-2docA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd6 H CHAIN OF FAB OF
ATN-615 ANTI-UPAR
ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS H  13
PRO H  14
SER H  84
SER H  82
 None
 1.34A 3ijxH-2fd6H:
undetectable		 3ijxH-2fd6H:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzx PUTATIVE TATD
RELATED DNASE

(Staphylococcus
aureus) 		PF01026
(TatD_DNase) 		4 LYS A 188
PRO A 187
SER A 154
LEU A 233
 None
 1.28A 3ijxH-2gzxA:
undetectable		 3ijxH-2gzxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzx PUTATIVE TATD
RELATED DNASE

(Staphylococcus
aureus) 		PF01026
(TatD_DNase) 		4 LYS A 188
PRO A 187
SER A 156
LEU A 233
 None
 1.28A 3ijxH-2gzxA:
undetectable		 3ijxH-2gzxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m72 UNCHARACTERIZED
THIOREDOXIN-LIKE
PROTEIN

(Porphyromonas
gingivalis) 		PF00578
(AhpC-TSA) 		4 LYS A  83
PRO A  84
LEU A  97
SER A  72
 None
 1.43A 3ijxH-2m72A:
undetectable		 3ijxH-2m72A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpm EOTAXIN

(Homo sapiens) 		PF00048
(IL8) 		4 LYS A  73
PRO A  72
SER A  69
SER A  25
 None
 1.49A 3ijxH-2mpmA:
undetectable		 3ijxH-2mpmA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6s VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF11921
(DUF3439)
PF12799
(LRR_4)
PF13855
(LRR_8) 		4 LYS A 223
PRO A 224
SER A 215
SER A 194
 None
 1.42A 3ijxH-2o6sA:
undetectable		 3ijxH-2o6sA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		4 LYS A  75
SER A  72
LEU A  61
SER A  58
 None
 1.09A 3ijxH-2ojhA:
undetectable		 3ijxH-2ojhA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		no annotation 4 PRO G  29
SER G  31
LEU G 161
SER G 159
 None
 1.23A 3ijxH-2ooxG:
undetectable		 3ijxH-2ooxG:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acf BETA-1,4-ENDOGLUCANA
SE

([Clostridium]
josui) 		PF03424
(CBM_17_28) 		4 PRO A  82
SER A  80
LEU A  52
SER A  50
 None
 1.39A 3ijxH-3acfA:
undetectable		 3ijxH-3acfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22

(Homo sapiens) 		PF00225
(Kinesin) 		4 LYS A 213
PRO A 214
SER A 216
LEU A 188
 None
 1.38A 3ijxH-3bfnA:
undetectable		 3ijxH-3bfnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjz PHOSPHOHEPTOSE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13580
(SIS_2) 		4 LYS A  45
PRO A  77
SER A  75
SER A  62
 None
 1.35A 3ijxH-3bjzA:
undetectable		 3ijxH-3bjzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		4 LYS A 151
PRO A 150
SER A 128
LEU A  88
 None
 1.40A 3ijxH-3clhA:
undetectable		 3ijxH-3clhA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxa SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 PRO A  25
SER A  22
LEU A  33
SER A 165
 None
 1.43A 3ijxH-3fxaA:
undetectable		 3ijxH-3fxaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LYS A 223
PRO A 224
LEU A 229
SER A 250
 None
 1.43A 3ijxH-3gg4A:
undetectable		 3ijxH-3gg4A:
18.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 LYS A 104
PRO A 105
LEU A 239
SER A 242
 None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
 0.59A 3ijxH-3h6tA:
42.6		 3ijxH-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 LYS A 104
PRO A 105
SER A 108
LEU A 239
 None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
 0.83A 3ijxH-3h6tA:
42.6		 3ijxH-3h6tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei) 		PF00348
(polyprenyl_synt) 		4 LYS A 246
SER A 243
LEU A 250
SER A 253
 None
 1.49A 3ijxH-3ipiA:
undetectable		 3ijxH-3ipiA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		4 PRO B 608
SER B 612
LEU B 658
SER B 663
 None
 1.43A 3ijxH-3jb9B:
undetectable		 3ijxH-3jb9B:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu OXYGEN-EVOLVING
ENHANCER PROTEIN 3,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF05757
(PsbQ) 		4 LYS Q  96
PRO Q  97
LEU Q 104
SER Q 103
 None
 1.25A 3ijxH-3jcuQ:
undetectable		 3ijxH-3jcuQ:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz2 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		4 LYS A 156
SER A  39
LEU A 316
SER A 314
 None
 1.38A 3ijxH-3mz2A:
undetectable		 3ijxH-3mz2A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		4 PRO A  19
SER A 220
LEU A  39
SER A  22
 None
 1.27A 3ijxH-3n2xA:
undetectable		 3ijxH-3n2xA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE

(Enterobacter
cloacae) 		PF00328
(His_Phos_2) 		4 PRO A 200
SER A 198
LEU A 207
SER A 206
 None
 1.44A 3ijxH-3ntlA:
undetectable		 3ijxH-3ntlA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		4 PRO A 241
SER A  91
LEU A 185
SER A 187
 None
 1.41A 3ijxH-3nx3A:
undetectable		 3ijxH-3nx3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9c CAFFEIC ACID
O-METHYLTRANSFERASE

(Lolium perenne) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 PRO A  55
SER A 100
LEU A  45
SER A  52
 None
 1.43A 3ijxH-3p9cA:
undetectable		 3ijxH-3p9cA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzv ANTI-DENGUE MAB 4E11

(Mus musculus) 		PF07686
(V-set) 		4 LYS B  14
PRO B  15
SER B  89
SER B  86
 None
 1.45A 3ijxH-3uzvB:
undetectable		 3ijxH-3uzvB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 PRO A 358
SER A 400
LEU A 363
SER A 395
 None
 1.21A 3ijxH-3v4pA:
undetectable		 3ijxH-3v4pA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w8h SERINE/THREONINE-PRO
TEIN KINASE 25

(Homo sapiens) 		PF06840
(DUF1241) 		4 LYS B  -2
PRO B 398
SER B 396
SER B 401
 None
 1.13A 3ijxH-3w8hB:
undetectable		 3ijxH-3w8hB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		4 LYS A  71
PRO A  72
SER A  74
SER A 135
 None
None
SO4  A1332 (-4.8A)
None
 1.32A 3ijxH-4aa9A:
undetectable		 3ijxH-4aa9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 PRO A 700
SER A 702
LEU A 655
SER A 741
 None
 1.35A 3ijxH-4b56A:
undetectable		 3ijxH-4b56A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dw2 FAB FRAGMENT OF
PRO-UPA ANTIBODY
MAB-112

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS H  13
PRO H  14
SER H  84
SER H  82
 None
 1.38A 3ijxH-4dw2H:
undetectable		 3ijxH-4dw2H:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LYS A1016
SER A1149
LEU A1177
SER A1174
 None
 1.16A 3ijxH-4e9xA:
undetectable		 3ijxH-4e9xA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebz CHITIN ELICITOR
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF01476
(LysM) 		4 LYS A  25
SER A 159
LEU A  99
SER A 154
 None
 1.25A 3ijxH-4ebzA:
undetectable		 3ijxH-4ebzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg2 CYTIDINE DEAMINASE

(Vibrio cholerae) 		PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2) 		4 PRO A 239
SER A 237
LEU A 263
SER A 212
 None
 1.15A 3ijxH-4eg2A:
undetectable		 3ijxH-4eg2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyc CATHELICIDIN
ANTIMICROBIAL
PEPTIDE

(Homo sapiens) 		PF00666
(Cathelicidins) 		4 LYS A  75
PRO A  76
SER A  78
LEU A 114
 None
 1.06A 3ijxH-4eycA:
undetectable		 3ijxH-4eycA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		4 PRO A 213
SER A 192
LEU A 239
SER A 238
 None
 1.16A 3ijxH-4fs7A:
undetectable		 3ijxH-4fs7A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		4 LYS A 245
PRO A 247
SER A 249
SER A 552
 None
 1.37A 3ijxH-4issA:
2.4		 3ijxH-4issA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		4 PRO A  19
SER A 220
LEU A  39
SER A  22
 None
 1.27A 3ijxH-4oe7A:
undetectable		 3ijxH-4oe7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roq MALYL-COA
LYASE/BETA-METHYLMAL
YL-COA LYASE

(Methylobacterium
extorquens) 		PF03328
(HpcH_HpaI) 		4 PRO A  25
SER A  23
LEU A  66
SER A  31
 None
 1.48A 3ijxH-4roqA:
undetectable		 3ijxH-4roqA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 PRO A 179
SER A 160
LEU A 206
SER A 205
 None
 1.45A 3ijxH-4v2dA:
undetectable		 3ijxH-4v2dA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		no annotation 4 LYS A 162
SER A 127
LEU A  98
SER A  99
 None
 1.47A 3ijxH-4yk2A:
undetectable		 3ijxH-4yk2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 PRO A 404
SER A 406
LEU A 396
SER A 542
 None
 1.24A 3ijxH-5a7mA:
undetectable		 3ijxH-5a7mA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		4 LYS K 493
PRO K 494
SER K 489
LEU K 496
 None
 1.20A 3ijxH-5anbK:
undetectable		 3ijxH-5anbK:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)

(Bdellovibrio
bacteriovorus) 		PF06963
(FPN1) 		4 PRO A 299
SER A 294
LEU A 307
SER A 311
 None
 1.05A 3ijxH-5aynA:
undetectable		 3ijxH-5aynA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT

(Streptomyces) 		PF04820
(Trp_halogenase) 		4 LYS A 207
SER A 212
LEU A  83
SER A  82
 None
 1.18A 3ijxH-5bulA:
undetectable		 3ijxH-5bulA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm4 METHYLTRANSFERASE
DOMAIN FAMILY

(Bacillus
pumilus) 		PF13489
(Methyltransf_23) 		4 LYS A 248
SER A 192
LEU A 160
SER A 188
 None
None
5DA  A 302 ( 4.5A)
5DA  A 302 (-2.8A)
 1.43A 3ijxH-5dm4A:
undetectable		 3ijxH-5dm4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 PRO A 338
SER A 442
LEU A 345
SER A 341
 None
 1.50A 3ijxH-5dqfA:
undetectable		 3ijxH-5dqfA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3j ANTIBODY 2D10 SINGLE
CHAIN VARIABLE
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 LYS C 182
PRO C 183
SER C 257
SER C 254
 None
 1.24A 3ijxH-5f3jC:
undetectable		 3ijxH-5f3jC:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		4 PRO A 182
SER A 149
LEU A  68
SER A  71
 None
 1.18A 3ijxH-5fyaA:
undetectable		 3ijxH-5fyaA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		4 PRO A 493
SER A 423
LEU A 530
SER A 409
 None
 1.20A 3ijxH-5gggA:
undetectable		 3ijxH-5gggA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gve DNA TOPOISOMERASE
3-BETA-1

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 LYS A  10
PRO A  11
SER A  37
SER A  16
 None
 0.88A 3ijxH-5gveA:
undetectable		 3ijxH-5gveA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
coronavirus
HKU1;
Human
immunodeficiency
virus 1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 LYS A 809
SER A 914
LEU A 850
SER A 806
 None
 1.43A 3ijxH-5i08A:
undetectable		 3ijxH-5i08A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LYS A 245
PRO A 247
SER A 249
SER A 552
 None
 1.39A 3ijxH-5i8iA:
undetectable		 3ijxH-5i8iA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 LYS A 169
PRO A 168
SER A 165
SER A 240
 None
 1.40A 3ijxH-5jn9A:
undetectable		 3ijxH-5jn9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 PRO A 613
SER A 418
LEU A 699
SER A 697
 None
 1.47A 3ijxH-5jp0A:
undetectable		 3ijxH-5jp0A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens) 		PF00452
(Bcl-2) 		4 PRO A 289
SER A 285
LEU A 179
SER A 183
 None
 1.16A 3ijxH-5jsbA:
undetectable		 3ijxH-5jsbA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 LYS A 493
PRO A 494
LEU A 751
SER A 754
 None
 0.54A 3ijxH-5l1bA:
22.1		 3ijxH-5l1bA:
70.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcl DNA REPAIR PROTEIN
RAD14

(Saccharomyces
cerevisiae) 		PF05181
(XPA_C) 		4 LYS A 254
PRO A 255
SER A 259
LEU A 267
 None
 1.44A 3ijxH-5lclA:
undetectable		 3ijxH-5lclA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcl DNA REPAIR PROTEIN
RAD14

(Saccharomyces
cerevisiae) 		PF05181
(XPA_C) 		4 LYS B 254
PRO B 255
SER B 259
LEU B 267
 None
 1.42A 3ijxH-5lclB:
undetectable		 3ijxH-5lclB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens;
Mus musculus) 		PF00452
(Bcl-2) 		4 PRO A 289
SER A 285
LEU A 179
SER A 183
 None
 1.17A 3ijxH-5mevA:
undetectable		 3ijxH-5mevA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mi0 RETICULOCYTE
BINDING-LIKE PROTEIN
5,RETICULOCYTE
BINDING PROTEIN 5

(Plasmodium
falciparum) 		no annotation 4 PRO A 177
SER A 160
LEU A 468
SER A 472
 None
 1.34A 3ijxH-5mi0A:
undetectable		 3ijxH-5mi0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 LYS A 334
PRO A 306
SER A 308
LEU A 273
 None
 1.49A 3ijxH-5nd1A:
undetectable		 3ijxH-5nd1A:
14.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 LYS A 493
PRO A 494
LEU A 751
SER A 754
 None
 0.61A 3ijxH-5welA:
32.3		 3ijxH-5welA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
PRO A 494
SER A 497
LEU A 751
SER A 754
 None
CYZ  A1302 (-4.5A)
CYZ  A1302 (-3.2A)
None
CYZ  A1302 ( 4.1A)
 0.92A 3ijxH-5weoA:
24.8		 3ijxH-5weoA:
66.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 PRO A 123
SER A 135
LEU A 120
SER A  86
 None
 1.43A 3ijxH-5x4jA:
undetectable		 3ijxH-5x4jA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y91 BETA-2-MICROGLOBULIN

(Ctenopharyngodon
idella) 		PF07654
(C1-set) 		4 LYS B  71
PRO B  72
SER B  95
SER B  75
 None
 1.43A 3ijxH-5y91B:
undetectable		 3ijxH-5y91B:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 LYS A 205
PRO A 207
SER A 217
LEU A 283
 MLY  A 204 ( 3.3A)
None
None
None
 1.38A 3ijxH-5z5cA:
undetectable		 3ijxH-5z5cA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 PRO A 219
SER A 199
LEU A 246
SER A 245
 None
 1.27A 3ijxH-5zlnA:
undetectable		 3ijxH-5zlnA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 4 LYS B 153
SER B 431
LEU B 149
SER B 435
 None
 1.30A 3ijxH-6btmB:
undetectable		 3ijxH-6btmB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 4 LYS 1 275
SER 1 151
LEU 1 271
SER 1 269
 None
 1.18A 3ijxH-6c261:
undetectable		 3ijxH-6c261:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 4 PRO A 270
SER A 266
LEU A 160
SER A 164
 None
 1.28A 3ijxH-6dm8A:
7.9		 3ijxH-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek2 SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 4 LYS H 182
PRO H 183
SER H 257
SER H 254
 None
 1.44A 3ijxH-6ek2H:
undetectable		 3ijxH-6ek2H:
18.47