SIMILAR PATTERNS OF AMINO ACIDS FOR 3IJD_B_C2FB314

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus) 		PF01177
(Asp_Glu_race) 		5 TYR A  30
LEU A 220
VAL A 245
LEU A 239
ILE A 238
 None
 1.10A 3ijdB-1b74A:
0.0		 3ijdB-1b74A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		5 TYR A 189
VAL A 206
GLY A 205
ILE A 227
ILE A 343
 None
 1.11A 3ijdB-1dcuA:
undetectable		 3ijdB-1dcuA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)

(Agrobacterium
tumefaciens) 		PF00561
(Abhydrolase_1) 		5 VAL A 104
GLY A 105
LEU A 113
ILE A 241
ILE A 284
 None
 1.07A 3ijdB-1ehyA:
1.2		 3ijdB-1ehyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 LEU A 268
VAL A 275
GLY A 282
ILE A 192
LEU A 252
 None
 0.95A 3ijdB-1fp2A:
undetectable		 3ijdB-1fp2A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Leishmania
mexicana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A 309
GLY A 290
LEU A 289
ARG A 342
ILE A 302
 None
 1.16A 3ijdB-1gyqA:
0.0		 3ijdB-1gyqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		5 LEU A 123
GLY A 243
ILE A  89
ARG A  87
LEU A  53
 None
 1.13A 3ijdB-1hylA:
undetectable		 3ijdB-1hylA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n31 L-CYSTEINE/CYSTINE
LYASE C-DES

(Synechocystis
sp. PCC 6714) 		PF00266
(Aminotran_5) 		5 LEU A 286
VAL A 231
GLY A 232
LEU A  63
ILE A  60
 None
 1.05A 3ijdB-1n31A:
0.1		 3ijdB-1n31A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8g HYPOTHETICAL PROTEIN
YBDK

(Escherichia
coli) 		PF04107
(GCS2) 		5 VAL A 139
GLY A 140
ILE A 325
ARG A  67
LEU A 264
 None
 1.15A 3ijdB-1r8gA:
0.0		 3ijdB-1r8gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5j HYPOTHETICAL PROTEIN
MJ1187

(Methanocaldococcus
jannaschii) 		PF03747
(ADP_ribosyl_GH) 		5 VAL A 117
GLY A 116
ARG A 127
LEU A 103
ILE A  98
 None
 1.15A 3ijdB-1t5jA:
undetectable		 3ijdB-1t5jA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 TYR A 182
LEU A 209
VAL A 152
GLY A 153
ILE A 132
 None
None
None
SO4  A 610 (-3.0A)
None
 1.10A 3ijdB-1vcnA:
undetectable		 3ijdB-1vcnA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG

(Clostridium
acetobutylicum) 		PF04321
(RmlD_sub_bind) 		5 LEU A  85
VAL A  92
GLY A  93
LEU A   4
ILE A  28
 None
 0.70A 3ijdB-1vl0A:
undetectable		 3ijdB-1vl0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 VAL A 243
GLY A 245
ILE A 178
LEU A 215
ILE A 212
 None
 1.00A 3ijdB-1w27A:
undetectable		 3ijdB-1w27A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv2 HYPOTHETICAL
PROTEIN, SIMILAR TO
ALPHA-ACETOLACTATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF03306
(AAL_decarboxy) 		5 TYR A  54
VAL A 156
GLY A 157
ILE A  76
ILE A  25
 None
 1.14A 3ijdB-1xv2A:
undetectable		 3ijdB-1xv2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4w HYPOTHETICAL
PROTEIN, CONSERVED

(Leishmania
major) 		PF08950
(DUF1861) 		5 LEU A 231
CYH A 205
VAL A 192
GLY A 207
LEU A 181
 None
 0.99A 3ijdB-2b4wA:
undetectable		 3ijdB-2b4wA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ex5 DNA ENDONUCLEASE
I-CEUI

(Chlamydomonas
moewusii) 		PF00961
(LAGLIDADG_1) 		5 VAL A  95
GLY A  97
ILE A 113
LEU A  43
ILE A  23
 None
 1.16A 3ijdB-2ex5A:
undetectable		 3ijdB-2ex5A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z CHEMOTAXIS PROTEIN
CHEC

(Thermotoga
maritima) 		PF04509
(CheC) 		5 LEU A 102
GLY A  93
ILE A  30
LEU A 110
ILE A 113
 None
 1.12A 3ijdB-2f9zA:
undetectable		 3ijdB-2f9zA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis) 		PF00696
(AA_kinase) 		5 LEU A  16
VAL A  89
GLY A  88
ILE A 127
ILE A   9
 None
 1.05A 3ijdB-2jjxA:
undetectable		 3ijdB-2jjxA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4h HIV-2 MYRISTOYLATED
MATRIX PROTEIN

(Human
immunodeficiency
virus 2) 		PF00540
(Gag_p17) 		5 LEU A  75
LEU A  21
ILE A  85
LEU A  64
ILE A  60
 None
None
MYR  A   1 ( 3.4A)
None
None
 1.11A 3ijdB-2k4hA:
undetectable		 3ijdB-2k4hA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwv DNA POLYMERASE IOTA

(Mus musculus) 		no annotation 5 LEU A 517
VAL A 500
GLY A 499
GLN A 502
LEU A 491
 None
 1.12A 3ijdB-2kwvA:
undetectable		 3ijdB-2kwvA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omd MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2

(Aquifex
aeolicus) 		PF02391
(MoaE) 		5 LEU A  36
CYH A 115
VAL A 119
LEU A  38
ILE A  40
 None
None
None
NA  A 701 ( 4.9A)
None
 1.15A 3ijdB-2omdA:
undetectable		 3ijdB-2omdA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B

(Bos taurus) 		PF00400
(WD40) 		5 LEU C 228
VAL C 220
GLY C 207
ILE C 332
ILE C 253
 None
 1.02A 3ijdB-2p9nC:
undetectable		 3ijdB-2p9nC:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyo O-METHYLTRANSFERASE

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 LEU A 273
VAL A 280
GLY A 287
ILE A 197
LEU A 257
 None
 0.98A 3ijdB-2qyoA:
undetectable		 3ijdB-2qyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 154
GLY A 220
ARG A 394
LEU A  15
ILE A  17
 LEU  A 154 ( 0.6A)
GLY  A 220 ( 0.0A)
ARG  A 394 ( 0.6A)
LEU  A  15 ( 0.6A)
ILE  A  17 ( 0.7A)
 1.14A 3ijdB-2vbfA:
undetectable		 3ijdB-2vbfA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm8 MAGNESIUM-DEPENDENT
PHOSPHATASE 1

(Homo sapiens) 		PF12689
(Acid_PPase) 		5 LEU A   8
VAL A 137
GLY A 136
ILE A 102
LEU A 108
 None
 0.86A 3ijdB-2wm8A:
undetectable		 3ijdB-2wm8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		5 VAL J 302
GLY J 303
LEU J 307
ILE J 332
ILE J 379
 None
None
GOL  J2002 ( 4.1A)
None
None
 0.97A 3ijdB-2wp8J:
undetectable		 3ijdB-2wp8J:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		5 LEU A 208
VAL A 216
LEU A 232
ILE A 130
LEU A 179
 None
 1.16A 3ijdB-3c3kA:
undetectable		 3ijdB-3c3kA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 352
VAL A 370
GLY A 369
ILE A 122
LEU A 316
 None
 1.06A 3ijdB-3ddmA:
7.5		 3ijdB-3ddmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di4 UNCHARACTERIZED
PROTEIN DUF1989

(Ruegeria
pomeroyi) 		PF09347
(DUF1989) 		5 CYH A 237
VAL A  78
GLY A  79
LEU A 256
ILE A 146
 ZN  A 286 (-2.3A)
None
None
None
None
 1.05A 3ijdB-3di4A:
undetectable		 3ijdB-3di4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 LEU A 358
VAL A  12
GLY A  13
ARG A 186
LEU A 225
 None
FAD  A 500 ( 4.5A)
FAD  A 500 (-3.5A)
FAD  A 500 ( 4.4A)
None
 1.01A 3ijdB-3djdA:
undetectable		 3ijdB-3djdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 269
GLY A 270
LEU A  99
ARG A 277
ILE A 311
 None
 1.02A 3ijdB-3eezA:
7.4		 3ijdB-3eezA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE

(Bacillus
subtilis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 LEU A 106
VAL A 111
GLY A 112
ILE A  88
ILE A   6
 None
 1.12A 3ijdB-3egoA:
undetectable		 3ijdB-3egoA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3els PRE-MRNA LEAKAGE
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		5 CYH A 141
VAL A 106
GLY A 107
ILE A  82
ILE A 200
 None
 1.04A 3ijdB-3elsA:
undetectable		 3ijdB-3elsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		5 LEU A 186
VAL A 181
LEU A 146
ILE A 174
ILE A 216
 None
 1.16A 3ijdB-3ffhA:
undetectable		 3ijdB-3ffhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv0 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Agrobacterium
fabrum) 		PF13377
(Peripla_BP_3) 		5 LEU A 230
GLY A 237
LEU A 240
ILE A 272
ILE A 290
 None
 1.15A 3ijdB-3gv0A:
undetectable		 3ijdB-3gv0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 LEU A  98
CYH A  74
GLY A   7
ILE A  27
LEU A  70
 None
None
NDP  A 300 (-3.0A)
None
None
 1.04A 3ijdB-3hwrA:
undetectable		 3ijdB-3hwrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 LEU A  58
GLY A 420
LEU A 421
ILE A  91
LEU A  86
 None
None
NA  A 576 (-4.9A)
None
None
 1.12A 3ijdB-3hwwA:
undetectable		 3ijdB-3hwwA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		5 LEU A 297
VAL A 438
GLY A 437
LEU A 427
ILE A 424
 None
 1.16A 3ijdB-3i6dA:
undetectable		 3ijdB-3i6dA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ijd UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF02219
(MTHFR) 		12 TYR A  52
LEU A  54
CYH A  95
VAL A 121
GLY A 122
LEU A 134
ILE A 155
ARG A 158
ARG A 168
GLN A 183
LEU A 231
ILE A 233
 C2F  A 314 (-3.6A)
None
C2F  A 314 ( 4.1A)
C2F  A 314 (-4.0A)
C2F  A 314 (-3.5A)
C2F  A 314 ( 4.4A)
None
C2F  A 314 (-3.5A)
None
C2F  A 314 (-3.4A)
C2F  A 314 (-3.9A)
None
 0.29A 3ijdB-3ijdA:
50.0		 3ijdB-3ijdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io5 RECOMBINATION AND
REPAIR PROTEIN

(Escherichia
virus T4) 		PF00154
(RecA) 		5 LEU A 145
VAL A 115
ILE A 123
LEU A 175
ILE A 178
 None
 1.13A 3ijdB-3io5A:
undetectable		 3ijdB-3io5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 LEU A 165
VAL A  27
GLY A  26
ILE A  21
LEU A 248
 None
 1.11A 3ijdB-3j4sA:
1.9		 3ijdB-3j4sA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 LEU A1010
GLY A1017
LEU A1020
GLN A1199
ILE A1204
 None
 1.15A 3ijdB-3kg9A:
undetectable		 3ijdB-3kg9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 VAL A 301
GLY A 300
LEU A 225
ILE A 404
ILE A 382
 None
 1.09A 3ijdB-3lkdA:
undetectable		 3ijdB-3lkdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00287
(Na_K-ATPase) 		5 TYR B 112
LEU B 153
GLY B 231
ILE B 178
ILE B  80
 None
 1.07A 3ijdB-3n23B:
undetectable		 3ijdB-3n23B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oum TOXOFLAVIN-DEGRADING
ENZYME

(Paenibacillus
polymyxa) 		PF00903
(Glyoxalase) 		5 LEU A  25
GLY A  73
ILE A 115
LEU A  41
ILE A 136
 None
 1.00A 3ijdB-3oumA:
undetectable		 3ijdB-3oumA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU B  21
VAL B  32
GLY B  34
LEU B   8
ILE B 172
 None
 1.16A 3ijdB-3pcoB:
undetectable		 3ijdB-3pcoB:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 505
CYH A 508
VAL A 311
GLY A 310
ILE A 461
 None
 1.11A 3ijdB-3q9tA:
undetectable		 3ijdB-3q9tA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r31 BETAINE ALDEHYDE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF00171
(Aldedh) 		5 LEU A 451
GLY A 422
LEU A 439
ARG A 297
LEU A 282
 None
 1.05A 3ijdB-3r31A:
undetectable		 3ijdB-3r31A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT

(Mycobacterium
marinum) 		PF00202
(Aminotran_3) 		5 LEU A 432
VAL A 407
GLY A 406
ILE A 442
LEU A 436
 None
 1.14A 3ijdB-3r4tA:
undetectable		 3ijdB-3r4tA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7w EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
nitratireducens) 		PF02335
(Cytochrom_C552) 		5 GLY A 285
LEU A 286
ILE A 193
ARG A 282
GLN A 190
 None
None
HEC  A1002 ( 4.2A)
HEC  A1002 (-3.1A)
None
 1.11A 3ijdB-3s7wA:
undetectable		 3ijdB-3s7wA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 LEU A 384
GLY A 373
ILE A 367
LEU A 389
ILE A 393
 None
 1.05A 3ijdB-3sqgA:
undetectable		 3ijdB-3sqgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		5 GLY A 285
LEU A 286
ILE A 193
ARG A 282
GLN A 190
 None
None
HEC  A1002 (-4.1A)
HEC  A1002 (-3.0A)
None
 1.11A 3ijdB-3ttbA:
undetectable		 3ijdB-3ttbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 CYH A 232
VAL A  88
GLY A  89
ILE A 165
ILE A 141
 None
 1.05A 3ijdB-3vueA:
undetectable		 3ijdB-3vueA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 CYH A 232
VAL A  88
GLY A  89
ILE A 165
LEU A 206
 None
 1.17A 3ijdB-3vueA:
undetectable		 3ijdB-3vueA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 CYH A 232
VAL A  88
LEU A 105
ILE A 165
ILE A 141
 None
 1.13A 3ijdB-3vueA:
undetectable		 3ijdB-3vueA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi) 		PF09522
(RE_R_Pab1) 		5 LEU A  78
VAL A 164
GLY A 148
ILE A 206
LEU A 201
 None
ADE  A 301 (-3.8A)
None
None
None
 1.13A 3ijdB-3wazA:
undetectable		 3ijdB-3wazA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi) 		PF09522
(RE_R_Pab1) 		5 TYR A  68
VAL A 164
GLY A 148
ILE A 206
LEU A 201
 ADE  A 301 (-4.2A)
ADE  A 301 (-3.8A)
None
None
None
 0.83A 3ijdB-3wazA:
undetectable		 3ijdB-3wazA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		5 LEU A 218
VAL A 227
GLY A 226
LEU A 307
LEU A 275
 None
 1.14A 3ijdB-4a1fA:
undetectable		 3ijdB-4a1fA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cz1 KYNURENINE
FORMAMIDASE

(Bacillus
anthracis) 		PF04199
(Cyclase) 		5 LEU A 142
VAL A 104
ILE A 209
LEU A 187
ILE A 206
 None
 1.14A 3ijdB-4cz1A:
undetectable		 3ijdB-4cz1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 122
GLY A 342
ILE A  33
LEU A 351
ILE A 357
 None
 1.11A 3ijdB-4dpkA:
undetectable		 3ijdB-4dpkA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ea1 DEHYDROSQUALENE
SYNTHASE

(Staphylococcus
aureus) 		PF00494
(SQS_PSY) 		5 LEU A 126
VAL A 133
LEU A 107
LEU A 166
ILE A 167
 None
3RX  A 301 (-4.2A)
3RX  A 301 ( 4.9A)
None
None
 1.16A 3ijdB-4ea1A:
undetectable		 3ijdB-4ea1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE

(Coffea
canephora) 		PF02458
(Transferase) 		5 TYR A 432
CYH A 265
LEU A 367
ILE A 403
ILE A 236
 None
 1.10A 3ijdB-4g0bA:
undetectable		 3ijdB-4g0bA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A  80
VAL A 240
GLY A 241
LEU A 287
ILE A 308
 None
 1.08A 3ijdB-4h1sA:
undetectable		 3ijdB-4h1sA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		6 LEU A 197
VAL A 177
GLY A 178
LEU A 235
ILE A 250
LEU A 353
 None
 1.49A 3ijdB-4hjhA:
undetectable		 3ijdB-4hjhA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		5 TYR A  37
LEU A  38
ILE A 356
LEU A 277
ILE A 281
 None
 1.10A 3ijdB-4iw7A:
undetectable		 3ijdB-4iw7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnf GLUTAMINE SYNTHETASE

(Bacillus
subtilis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 VAL A  78
ILE A  93
GLN A  24
LEU A 216
ILE A  32
 None
 1.12A 3ijdB-4lnfA:
undetectable		 3ijdB-4lnfA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnd CTP
L-MYO-INOSITOL-1-PHO
SPHATE
CYTIDYLYLTRANSFERASE
/CDP-L-MYO-INOSITOL
MYO-INOSITOLPHOSPHOT
RANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf)
PF12804
(NTP_transf_3) 		5 VAL A 385
ILE A 447
ARG A 446
LEU A 356
ILE A 355
 None
 1.12A 3ijdB-4mndA:
undetectable		 3ijdB-4mndA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4f INOSITOL
HEXAKISPHOSPHATE
KINASE

(Entamoeba
histolytica) 		PF03770
(IPK) 		5 LEU A 191
VAL A 133
GLY A 132
LEU A 260
ILE A 263
 None
 1.13A 3ijdB-4o4fA:
undetectable		 3ijdB-4o4fA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 GLY A 387
LEU A1237
ILE A 368
ARG A 384
GLN A 341
 None
 1.13A 3ijdB-4o9xA:
undetectable		 3ijdB-4o9xA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF00171
(Aldedh) 		5 LEU A 183
VAL A 164
GLY A 163
LEU A 242
ILE A 221
 None
 1.06A 3ijdB-4ou2A:
undetectable		 3ijdB-4ou2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Lactococcus
lactis) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 TYR A  79
GLY A 101
LEU A  84
LEU A  13
ILE A  52
 None
 1.08A 3ijdB-4pczA:
undetectable		 3ijdB-4pczA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 668
LEU A 494
ILE A 157
ARG A 147
ILE A 457
 None
 1.15A 3ijdB-4pd3A:
undetectable		 3ijdB-4pd3A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)

(Methylobacterium
extorquens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A  82
GLY A 158
ILE A 191
LEU A 166
ILE A 169
 None
 1.16A 3ijdB-4px1A:
undetectable		 3ijdB-4px1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 277
VAL A 329
GLY A 326
LEU A 272
ILE A 293
 None
 1.11A 3ijdB-4qdhA:
undetectable		 3ijdB-4qdhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00459
(Inositol_P) 		5 TYR A  60
VAL A 128
GLY A 127
LEU A 225
ILE A 152
 None
 1.17A 3ijdB-4qxdA:
undetectable		 3ijdB-4qxdA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 150
VAL A 204
ILE A 251
LEU A 549
ILE A 553
 None
 1.14A 3ijdB-4r1dA:
undetectable		 3ijdB-4r1dA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 LEU A 283
CYH A 252
VAL A  17
ILE A 403
ILE A 379
 None
 1.10A 3ijdB-4r7uA:
undetectable		 3ijdB-4r7uA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		6 LEU A  80
GLY A  20
LEU A  23
ILE A  15
LEU A 159
ILE A 339
 None
None
None
FAD  A 401 (-3.9A)
None
FAD  A 401 (-3.8A)
 1.44A 3ijdB-4yshA:
undetectable		 3ijdB-4yshA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbz URACIL-DNA
GLYCOSYLASE

(Sulfurisphaera
tokodaii) 		PF03167
(UDG) 		5 VAL A  40
GLY A  41
LEU A 121
GLN A 109
ILE A   7
 None
 1.07A 3ijdB-4zbzA:
undetectable		 3ijdB-4zbzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 LEU A 218
VAL A 227
GLY A 226
LEU A 307
LEU A 275
 None
 1.05A 3ijdB-4zc0A:
undetectable		 3ijdB-4zc0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmu DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF)
PF01590
(GAF) 		6 LEU A 147
VAL A  44
GLY A  43
ILE A  63
LEU A 129
ILE A  49
 None
 1.38A 3ijdB-4zmuA:
undetectable		 3ijdB-4zmuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2c XAA-PRO DIPEPTIDASE

(Mycobacterium
tuberculosis) 		PF01321
(Creatinase_N) 		5 VAL A  92
GLY A  93
ILE A  14
LEU A  23
ILE A  24
 None
 0.74A 3ijdB-5e2cA:
undetectable		 3ijdB-5e2cA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff5 PAAA

(Pantoea
agglomerans) 		PF00899
(ThiF) 		5 CYH A 147
LEU A 177
ILE A 162
LEU A 230
ILE A 247
 None
 1.13A 3ijdB-5ff5A:
undetectable		 3ijdB-5ff5A:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A

(Bacillus
subtilis;
Bacillus
subtilis;
Bacillus
subtilis) 		PF02463
(SMC_N)
PF02463
(SMC_N)
PF02616
(SMC_ScpA) 		6 VAL B1163
GLY B1162
LEU C 221
ILE B1147
LEU A   6
ILE A  44
 None
 1.21A 3ijdB-5h67B:
undetectable		 3ijdB-5h67B:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		5 VAL A  96
GLY A  97
LEU A  73
LEU A 302
ILE A 309
 None
 1.13A 3ijdB-5h7dA:
undetectable		 3ijdB-5h7dA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 5 LEU A  80
VAL A 240
GLY A 241
LEU A 287
ILE A 308
 None
 1.11A 3ijdB-5h7wA:
undetectable		 3ijdB-5h7wA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 311
LEU A 123
ILE A 157
LEU A 136
ILE A 139
 None
 1.07A 3ijdB-5idnA:
undetectable		 3ijdB-5idnA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		5 GLY A 548
LEU A 551
ILE A 531
LEU A 417
ILE A 419
 None
EDO  A 601 (-3.8A)
None
None
None
 1.17A 3ijdB-5il0A:
undetectable		 3ijdB-5il0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix1 MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3

(Mus musculus) 		PF07496
(zf-CW)
PF13589
(HATPase_c_3) 		5 LEU A 170
VAL A 127
GLY A 128
LEU A  77
ILE A 197
 None
 1.12A 3ijdB-5ix1A:
undetectable		 3ijdB-5ix1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8x TETRAHYDROMETHANOPTE
RIN
S-METHYLTRANSFERASE
SUBUNIT A

(Methanocaldococcus
jannaschii) 		PF04208
(MtrA) 		5 CYH A  52
VAL A  30
GLY A  50
ILE A  72
ILE A  67
 LMR  A 201 (-4.6A)
None
None
None
None
 1.02A 3ijdB-5l8xA:
undetectable		 3ijdB-5l8xA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lng PUTATIVE FML
FIMBRIAL ADHESIN
FMLD

(Escherichia
coli) 		PF09160
(FimH_man-bind) 		5 VAL A 117
GLY A 116
ILE A  26
LEU A  67
ILE A 108
 None
 1.14A 3ijdB-5lngA:
undetectable		 3ijdB-5lngA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 TYR A 318
LEU A 293
VAL A 310
GLY A 309
ILE A 126
 None
 1.16A 3ijdB-5mscA:
undetectable		 3ijdB-5mscA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878

(Staphylococcus
aureus) 		no annotation 5 LEU A 222
CYH A 199
VAL A 163
GLY A 164
ILE A 128
 None
None
None
None
FAD  A1001 ( 4.8A)
 1.08A 3ijdB-5na4A:
undetectable		 3ijdB-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		5 LEU A 271
VAL A  20
ILE A 236
ARG A 233
LEU A  12
 None
 0.96A 3ijdB-5ncwA:
undetectable		 3ijdB-5ncwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 5 LEU A 301
GLY A 415
LEU A 463
ILE A 455
LEU A 317
 None
 1.06A 3ijdB-5oatA:
undetectable		 3ijdB-5oatA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te7 HIV-1 GP120 CORE

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 GLY G 451
LEU G 260
ILE G 272
ARG G 273
ILE G 359
 None
 1.08A 3ijdB-5te7G:
undetectable		 3ijdB-5te7G:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uki RNA LARIAT
DEBRANCHING ENZYME,
PUTATIVE

(Entamoeba
histolytica) 		no annotation 5 TYR A  82
CYH A  42
VAL A  12
GLY A  13
LEU A 247
 None
 1.01A 3ijdB-5ukiA:
undetectable		 3ijdB-5ukiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF02463
(SMC_N)
no annotation 		6 VAL A1143
GLY A1142
LEU C 188
ILE A1127
LEU A   7
ILE A  46
 None
 1.40A 3ijdB-5xnsA:
undetectable		 3ijdB-5xnsA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao3 GASDERMIN-D

(Mus musculus) 		no annotation 5 LEU A 384
CYH A 448
LEU A 452
GLN A 404
LEU A 392
 None
 1.12A 3ijdB-6ao3A:
undetectable		 3ijdB-6ao3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvp 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		no annotation 6 LEU A  81
CYH A 106
VAL A  41
GLY A  42
LEU A  21
LEU A  68
 None
 1.42A 3ijdB-6bvpA:
undetectable		 3ijdB-6bvpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		5 LEU M 115
VAL M 171
GLY M 172
LEU h 105
LEU M 176
 None
 0.97A 3ijdB-6g2jM:
undetectable		 3ijdB-6g2jM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 THR A 599
LYS A 359
GLU A 544
 None
 0.98A 3ijdB-1bhgA:
12.7		 3ijdB-1bhgA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0w DIPHTHERIA TOXIN
REPRESSOR

(Corynebacterium
diphtheriae) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 THR A 180
LYS A   2
GLU A 175
 None
 1.02A 3ijdB-1c0wA:
undetectable		 3ijdB-1c0wA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE

(Geobacillus
stearothermophilus) 		PF09194
(Endonuc-BsobI) 		3 THR A 310
LYS A  37
GLU A  23
 None
 1.01A 3ijdB-1dc1A:
2.4		 3ijdB-1dc1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome) 		3 THR H 179
LYS H 195
GLU H 182
 None
 0.87A 3ijdB-1j2qH:
undetectable		 3ijdB-1j2qH:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeo HYPOTHETICAL PROTEIN
MJ1247

(Methanocaldococcus
jannaschii) 		PF01380
(SIS) 		3 THR A  77
LYS A 178
GLU A  74
 None
CME  A 177 ( 3.5A)
None
 0.96A 3ijdB-1jeoA:
undetectable		 3ijdB-1jeoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 THR A 353
LYS A  24
GLU A 354
 None
 0.83A 3ijdB-1kyiA:
2.1		 3ijdB-1kyiA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		3 THR A 380
LYS A 150
GLU A  21
 None
 0.96A 3ijdB-1phzA:
undetectable		 3ijdB-1phzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv5 HYPOTHETICAL PROTEIN
YWQG

(Bacillus
subtilis) 		PF09234
(DUF1963) 		3 THR A 164
LYS A 194
GLU A 161
 None
 0.71A 3ijdB-1pv5A:
undetectable		 3ijdB-1pv5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		3 THR A 395
LYS A 156
GLU A 384
 None
 0.91A 3ijdB-1pztA:
undetectable		 3ijdB-1pztA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Homo sapiens) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		3 THR A 244
LYS A 153
GLU A 245
 None
 0.94A 3ijdB-1q8kA:
undetectable		 3ijdB-1q8kA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4k SKELETAL MUSCLE
LIM-PROTEIN 3

(Homo sapiens) 		PF00412
(LIM) 		3 THR A  32
LYS A   1
GLU A  10
 None
None
ZN  A 201 ( 4.7A)
 0.81A 3ijdB-1x4kA:
undetectable		 3ijdB-1x4kA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avf COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 THR A  90
LYS A  16
GLU A  46
 None
 0.91A 3ijdB-2avfA:
undetectable		 3ijdB-2avfA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2g THREONINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		3 THR A 273
LYS A 437
GLU A 277
 None
 0.94A 3ijdB-2c2gA:
undetectable		 3ijdB-2c2gA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01156
(IU_nuc_hydro) 		3 THR A  59
LYS A 144
GLU A  61
 None
 0.99A 3ijdB-2c40A:
undetectable		 3ijdB-2c40A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		3 THR A 480
LYS A 175
GLU A 483
 None
 1.02A 3ijdB-2cjqA:
undetectable		 3ijdB-2cjqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi9 OUTER MEMBRANE
PROTEIN

(Bartonella
henselae) 		PF04430
(DUF498) 		3 THR A  55
LYS A  11
GLU A  57
 None
 0.75A 3ijdB-2fi9A:
undetectable		 3ijdB-2fi9A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE

(Streptomyces
virginiae) 		PF00550
(PP-binding) 		3 THR A6762
LYS A  -4
GLU A6761
 None
 0.99A 3ijdB-2mf4A:
undetectable		 3ijdB-2mf4A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob5 HYPOTHETICAL PROTEIN
ATU2016

(Agrobacterium
fabrum) 		PF05025
(RbsD_FucU) 		3 THR A  31
LYS A  -3
GLU A 132
 None
 0.90A 3ijdB-2ob5A:
undetectable		 3ijdB-2ob5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 3 THR A 170
LYS A 670
GLU A 205
 None
 1.02A 3ijdB-2po4A:
undetectable		 3ijdB-2po4A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE

(Escherichia
coli) 		PF02611
(CDH) 		3 THR A  33
LYS A 114
GLU A  41
 None
 0.78A 3ijdB-2pofA:
undetectable		 3ijdB-2pofA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcz OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		3 THR A 225
LYS A 310
GLU A 224
 None
 0.97A 3ijdB-2qczA:
undetectable		 3ijdB-2qczA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 THR A 168
LYS A 129
GLU A 174
 None
 1.00A 3ijdB-2waeA:
undetectable		 3ijdB-2waeA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		3 THR A 216
LYS A 391
GLU A 217
 None
 0.80A 3ijdB-2xa2A:
undetectable		 3ijdB-2xa2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 THR A  23
LYS A 160
GLU A  15
 None
 0.95A 3ijdB-2xr1A:
undetectable		 3ijdB-2xr1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 THR O 327
LYS O 427
GLU O 324
 None
 0.91A 3ijdB-2zf5O:
undetectable		 3ijdB-2zf5O:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 THR A  42
LYS A  15
GLU A  39
 None
 1.00A 3ijdB-2zr2A:
undetectable		 3ijdB-2zr2A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aex THREONINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		3 THR A 166
LYS A 322
GLU A 170
 None
 0.93A 3ijdB-3aexA:
undetectable		 3ijdB-3aexA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1

(Mycobacterium
tuberculosis) 		PF00296
(Bac_luciferase) 		3 THR A 204
LYS A 259
GLU A 201
 None
FLC  A 337 (-2.8A)
None
 0.81A 3ijdB-3b4yA:
14.0		 3ijdB-3b4yA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF03061
(4HBT) 		3 THR A 129
LYS A  12
GLU A  50
 None
 0.88A 3ijdB-3e8pA:
undetectable		 3ijdB-3e8pA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdj DEGV FAMILY PROTEIN

([Eubacterium]
eligens) 		PF02645
(DegV) 		3 THR A  28
LYS A  12
GLU A  31
 None
 1.00A 3ijdB-3fdjA:
undetectable		 3ijdB-3fdjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 THR A 119
LYS A   1
GLU A 178
 NAG  A 525 (-3.5A)
None
NAG  A 525 (-3.7A)
 0.90A 3ijdB-3gdnA:
undetectable		 3ijdB-3gdnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 THR A 133
LYS A 199
GLU A 131
 None
 0.99A 3ijdB-3iayA:
undetectable		 3ijdB-3iayA:
15.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ijd UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF02219
(MTHFR) 		3 THR A  19
LYS A 172
GLU A 280
 C2F  A 314 ( 3.8A)
C2F  A 314 (-2.5A)
C2F  A 314 (-3.3A)
 0.17A 3ijdB-3ijdA:
50.0		 3ijdB-3ijdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CWF5

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF02731
(SKIP_SNW)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 THR M 206
LYS A 114
GLU a  38
 None
 0.92A 3ijdB-3jb9M:
undetectable		 3ijdB-3jb9M:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jte RESPONSE REGULATOR
RECEIVER PROTEIN

(Ruminiclostridium
thermocellum) 		PF00072
(Response_reg) 		3 THR A  37
LYS A 106
GLU A  38
 None
 1.02A 3ijdB-3jteA:
undetectable		 3ijdB-3jteA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khd PYRUVATE KINASE

(Plasmodium
falciparum) 		PF00224
(PK)
PF02887
(PK_C) 		3 THR A 329
LYS A 200
GLU A 326
 None
 1.02A 3ijdB-3khdA:
9.8		 3ijdB-3khdA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khd PYRUVATE KINASE

(Plasmodium
falciparum) 		PF00224
(PK)
PF02887
(PK_C) 		3 THR A 329
LYS A 264
GLU A 326
 None
 0.97A 3ijdB-3khdA:
9.8		 3ijdB-3khdA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		3 THR A 103
LYS A  53
GLU A 105
 None
 0.97A 3ijdB-3lm5A:
undetectable		 3ijdB-3lm5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m16 TRANSALDOLASE

(Oleispira
antarctica) 		PF00923
(TAL_FSA) 		3 THR A 237
LYS A 139
GLU A 239
 None
 0.97A 3ijdB-3m16A:
7.8		 3ijdB-3m16A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 THR A 291
LYS A 401
GLU A 290
 None
 1.00A 3ijdB-3n0gA:
undetectable		 3ijdB-3n0gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o26 SALUTARIDINE
REDUCTASE

(Papaver
somniferum) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		3 THR A 141
LYS A  22
GLU A 143
 None
NDP  A 312 (-3.8A)
None
 0.99A 3ijdB-3o26A:
2.2		 3ijdB-3o26A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe5 UNCHARACTERIZED
PROTEIN

([Clostridium]
leptum) 		PF03816
(LytR_cpsA_psr) 		3 THR A 373
LYS A 276
GLU A 360
 None
 0.94A 3ijdB-3pe5A:
undetectable		 3ijdB-3pe5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 THR A 572
LYS A  19
GLU A 620
 None
 0.99A 3ijdB-3ppcA:
5.9		 3ijdB-3ppcA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 THR A 237
LYS A 189
GLU A 357
 None
None
OYP  A 664 (-3.6A)
 1.01A 3ijdB-3rdeA:
undetectable		 3ijdB-3rdeA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 THR A 119
LYS A   1
GLU A 178
 None
 0.86A 3ijdB-3redA:
undetectable		 3ijdB-3redA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		3 THR A 112
LYS A 184
GLU A 114
 None
 0.86A 3ijdB-3rhyA:
undetectable		 3ijdB-3rhyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb6 ARABINOSE METABOLISM
TRANSCRIPTIONAL
REPRESSOR

(Bacillus
subtilis) 		PF13377
(Peripla_BP_3) 		3 THR A 144
LYS A 279
GLU A 142
 None
None
ARB  A 400 (-4.4A)
 0.81A 3ijdB-3tb6A:
undetectable		 3ijdB-3tb6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		3 THR A 192
LYS A  67
GLU A 163
 None
 0.98A 3ijdB-3tbhA:
undetectable		 3ijdB-3tbhA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tih HIV-1 CLADE C
ZM109F.PB4 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 THR A 232
LYS A 357
GLU A 269
 None
 0.82A 3ijdB-3tihA:
undetectable		 3ijdB-3tihA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqx 2-AMINO-3-KETOBUTYRA
TE COENZYME A LIGASE

(Coxiella
burnetii) 		PF00155
(Aminotran_1_2) 		3 THR A 375
LYS A  61
GLU A  34
 None
 0.83A 3ijdB-3tqxA:
undetectable		 3ijdB-3tqxA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0i VOLTAGE-SENSOR
CONTAINING
PHOSPHATASE

(Ciona
intestinalis) 		PF00782
(DSPc)
PF10409
(PTEN_C2) 		3 THR A 565
LYS A 437
GLU A 547
 None
 0.80A 3ijdB-3v0iA:
undetectable		 3ijdB-3v0iA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 THR A 506
LYS A 441
GLU A 485
 None
 0.96A 3ijdB-3vueA:
undetectable		 3ijdB-3vueA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Escherichia
coli;
Archaeoglobus
fulgidus) 		PF13416
(SBP_bac_8) 		3 THR A 791
LYS A 681
GLU A 814
 None
 0.90A 3ijdB-3waiA:
undetectable		 3ijdB-3waiA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		3 THR A 535
LYS A 905
GLU A 529
 None
 1.00A 3ijdB-3zusA:
undetectable		 3ijdB-3zusA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Pseudomonas
aeruginosa) 		PF00483
(NTP_transferase) 		3 THR A 200
LYS A  25
GLU A 198
 None
 0.63A 3ijdB-4asyA:
undetectable		 3ijdB-4asyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi5 TRIOSEPHOSPHATE
ISOMERASE

(Giardia
intestinalis) 		PF00121
(TIM) 		3 THR A 140
LYS A  13
GLU A 134
 None
 0.90A 3ijdB-4bi5A:
9.6		 3ijdB-4bi5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2

(Danio rerio) 		PF01459
(Porin_3) 		3 THR X  70
LYS X  12
GLU X  84
 None
 0.87A 3ijdB-4bumX:
undetectable		 3ijdB-4bumX:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		3 THR J 271
LYS J  87
GLU J 274
 None
 0.89A 3ijdB-4cr4J:
undetectable		 3ijdB-4cr4J:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7o COP9 SIGNALOSOME
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF01398
(JAB) 		3 THR A 103
LYS A 219
GLU A  76
 None
 0.92A 3ijdB-4f7oA:
undetectable		 3ijdB-4f7oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 THR A 135
LYS A 194
GLU A 143
 None
 1.00A 3ijdB-4glxA:
undetectable		 3ijdB-4glxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxr MALONYL COA
SYNTHETASE,
BENZOATE-COA LIGASE
CHIMERIC PROTEIN

(Rhodopseudomonas
palustris;
Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 THR A 380
LYS A 492
GLU A 304
 None
MLY  A 491 ( 3.0A)
MG  A 602 ( 4.2A)
 1.00A 3ijdB-4gxrA:
undetectable		 3ijdB-4gxrA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8p BILE ACID
7A-DEHYDRATASE, BAIE

([Clostridium]
hiranonis) 		PF13577
(SnoaL_4) 		3 THR A  87
LYS A  58
GLU A  89
 None
 0.84A 3ijdB-4l8pA:
undetectable		 3ijdB-4l8pA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 THR A 876
LYS A 110
GLU A 874
 None
 0.87A 3ijdB-4q73A:
2.6		 3ijdB-4q73A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 THR A 291
LYS A 725
GLU A 295
 None
 0.94A 3ijdB-4wz9A:
undetectable		 3ijdB-4wz9A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		3 THR A 491
LYS A 527
GLU A 490
 None
 0.94A 3ijdB-4xjxA:
undetectable		 3ijdB-4xjxA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF00955
(HCO3_cotransp) 		3 THR A 685
LYS A 539
GLU A 681
 None
4KU  A1000 (-1.4A)
4KU  A1000 (-4.4A)
 0.88A 3ijdB-4yzfA:
undetectable		 3ijdB-4yzfA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT BETA
UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica;
Yersinia
enterocolitica) 		PF00699
(Urease_beta)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 THR B 135
LYS C 101
GLU B 137
 None
 0.97A 3ijdB-4z42B:
undetectable		 3ijdB-4z42B:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgz ANTIZYME INHIBITOR 1

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 THR A  67
LYS A 141
GLU A 271
 None
 0.85A 3ijdB-4zgzA:
8.3		 3ijdB-4zgzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 THR A 254
LYS A 699
GLU A 336
 None
 0.91A 3ijdB-4zktA:
undetectable		 3ijdB-4zktA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		3 THR A 273
LYS A 216
GLU A 270
 None
 0.82A 3ijdB-5a2aA:
10.8		 3ijdB-5a2aA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		3 THR A 469
LYS A 310
GLU A 475
 None
 0.86A 3ijdB-5a5gA:
3.2		 3ijdB-5a5gA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an1 GLUTATHIONE
S-TRANSFERASE

(Litopenaeus
vannamei) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 THR A 113
LYS A  50
GLU A 109
 None
GSH  A1220 (-3.6A)
None
 1.00A 3ijdB-5an1A:
undetectable		 3ijdB-5an1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq5 INSERTION SEQUENCE
IS5376 PUTATIVE
ATP-BINDING PROTEIN

(Geobacillus
stearothermophilus) 		PF01695
(IstB_IS21) 		3 THR A 112
LYS A 153
GLU A 167
 MG  A 302 ( 3.1A)
None
BEF  A 303 ( 4.9A)
 1.02A 3ijdB-5bq5A:
undetectable		 3ijdB-5bq5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		3 THR B  57
LYS B 379
GLU B  55
 None
 1.01A 3ijdB-5d9aB:
undetectable		 3ijdB-5d9aB:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		3 THR A 217
LYS A 261
GLU A 219
 None
 0.90A 3ijdB-5dtrA:
undetectable		 3ijdB-5dtrA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		3 THR A 384
LYS A 287
GLU A 116
 None
 0.96A 3ijdB-5fsaA:
undetectable		 3ijdB-5fsaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 3 THR I 280
LYS I 371
GLU I 338
 None
 1.02A 3ijdB-5furI:
undetectable		 3ijdB-5furI:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		3 THR A  71
LYS A 212
GLU A  93
 None
None
NAG  A 905 (-3.5A)
 0.56A 3ijdB-5gmhA:
undetectable		 3ijdB-5gmhA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 THR A  78
LYS A 115
GLU A  75
 None
 0.95A 3ijdB-5gz8A:
undetectable		 3ijdB-5gz8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idt GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		3 THR A 201
LYS A  26
GLU A 199
 None
THM  A 301 ( 3.8A)
None
 1.02A 3ijdB-5idtA:
undetectable		 3ijdB-5idtA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		3 THR A 200
LYS A  25
GLU A 198
 TRH  A 500 (-4.5A)
TRH  A 500 ( 4.0A)
None
 0.62A 3ijdB-5ifyA:
undetectable		 3ijdB-5ifyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		3 THR A 447
LYS A 364
GLU A 449
 None
 1.00A 3ijdB-5ihwA:
undetectable		 3ijdB-5ihwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C)
PF04390
(LptE) 		3 THR A 614
LYS B 158
GLU A 616
 None
 0.91A 3ijdB-5iv9A:
undetectable		 3ijdB-5iv9A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		3 THR A 191
LYS A 115
GLU A 188
 None
 0.95A 3ijdB-5iysA:
undetectable		 3ijdB-5iysA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j47 LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF06431
(Polyoma_lg_T_C) 		3 THR A 434
LYS A 372
GLU A 474
 None
 1.00A 3ijdB-5j47A:
undetectable		 3ijdB-5j47A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6n PROTEIN BMH1

(Saccharomyces
cerevisiae) 		no annotation 3 THR A 116
LYS A  13
GLU A 118
 None
 0.97A 3ijdB-5n6nA:
undetectable		 3ijdB-5n6nA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 3 THR A 426
LYS A  87
GLU A 368
 None
 0.81A 3ijdB-5necA:
undetectable		 3ijdB-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o98 ALCOHOL
DEHYDROGENASE 1

(Catharanthus
roseus) 		no annotation 3 THR A 128
LYS A  18
GLU A 130
 None
NAP  A 501 (-3.9A)
None
 0.80A 3ijdB-5o98A:
undetectable		 3ijdB-5o98A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9c OSMOPORIN OMP36

(Klebsiella
aerogenes) 		no annotation 3 THR C 201
LYS C 212
GLU C 203
 None
 0.96A 3ijdB-5o9cC:
undetectable		 3ijdB-5o9cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 THR A 377
LYS A 181
GLU A 368
 None
 0.93A 3ijdB-5t8tA:
undetectable		 3ijdB-5t8tA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2

(Homo sapiens;
Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 THR A 455
LYS B 277
GLU A 459
 None
 0.86A 3ijdB-5u1dA:
undetectable		 3ijdB-5u1dA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5us8 ARGININOSUCCINATE
SYNTHASE

(Bordetella
pertussis) 		PF00764
(Arginosuc_synth) 		3 THR A 201
LYS A 155
GLU A 203
 None
 0.91A 3ijdB-5us8A:
undetectable		 3ijdB-5us8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		3 THR A 197
LYS A 409
GLU A 202
 None
 0.85A 3ijdB-5xzbA:
undetectable		 3ijdB-5xzbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		3 THR A 197
LYS A 409
GLU A 371
 None
 0.97A 3ijdB-5xzbA:
undetectable		 3ijdB-5xzbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 3 THR A 319
LYS A 259
GLU A 316
 None
 0.95A 3ijdB-6b82A:
undetectable		 3ijdB-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvd LIGHT CHAIN

(Clostridium
botulinum) 		no annotation 3 THR A  80
LYS A  66
GLU A  83
 None
 0.79A 3ijdB-6bvdA:
undetectable		 3ijdB-6bvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d1q RNA
PYROPHOSPHOHYDROLASE

(Escherichia
coli) 		no annotation 3 THR B 118
LYS B   0
GLU B 120
 None
 1.01A 3ijdB-6d1qB:
undetectable		 3ijdB-6d1qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 THR A 216
LYS A 250
GLU A 213
 None
 0.92A 3ijdB-6emkA:
undetectable		 3ijdB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h25


(;
) 		no annotation
no annotation 		3 THR A  72
LYS B   6
GLU A 119
 None
 0.86A 3ijdB-6h25A:
undetectable		 3ijdB-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h7x -

(-) 		no annotation 3 THR A 388
LYS A  43
GLU A 384
 None
 1.01A 3ijdB-6h7xA:
undetectable		 3ijdB-6h7xA:
undetectable