SIMILAR PATTERNS OF AMINO ACIDS FOR 3IJD_A_C2FA314_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus) 		PF01177
(Asp_Glu_race) 		5 TYR A  30
LEU A 220
VAL A 245
LEU A 239
ILE A 238
 None
 1.11A 3ijdA-1b74A:
undetectable		 3ijdA-1b74A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A   5
GLY A  67
ILE A  50
LEU A  13
GLU A  77
 None
 1.07A 3ijdA-1bucA:
undetectable		 3ijdA-1bucA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		5 TYR A 189
VAL A 206
GLY A 205
ILE A 227
ILE A 343
 None
 1.10A 3ijdA-1dcuA:
undetectable		 3ijdA-1dcuA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)

(Agrobacterium
tumefaciens) 		PF00561
(Abhydrolase_1) 		5 VAL A 104
GLY A 105
LEU A 113
ILE A 241
ILE A 284
 None
 1.07A 3ijdA-1ehyA:
undetectable		 3ijdA-1ehyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 LEU A 268
VAL A 275
GLY A 282
ILE A 192
LEU A 252
 None
 1.01A 3ijdA-1fp2A:
undetectable		 3ijdA-1fp2A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqi SHORT CHAIN ACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 THR A 304
LEU A 256
GLY A  84
LEU A  29
ILE A 209
 None
 1.11A 3ijdA-1jqiA:
undetectable		 3ijdA-1jqiA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE

(Mus musculus) 		PF00709
(Adenylsucc_synt) 		5 LEU A 109
VAL A 102
GLY A  65
LEU A  85
ILE A  89
 None
 1.11A 3ijdA-1mf1A:
undetectable		 3ijdA-1mf1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG

(Clostridium
acetobutylicum) 		PF04321
(RmlD_sub_bind) 		5 LEU A  85
VAL A  92
GLY A  93
LEU A   4
ILE A  28
 None
 0.75A 3ijdA-1vl0A:
undetectable		 3ijdA-1vl0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 VAL A 243
GLY A 245
ILE A 178
LEU A 215
ILE A 212
 None
 1.02A 3ijdA-1w27A:
undetectable		 3ijdA-1w27A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn9 THE HYPOTHETICAL
PROTEIN (TT1805)

(Thermus
thermophilus) 		PF11432
(DUF3197) 		5 THR A  52
LEU A  50
VAL A   4
GLY A   5
LEU A  21
 None
 1.13A 3ijdA-1wn9A:
undetectable		 3ijdA-1wn9A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xbz 3-KETO-L-GULONATE
6-PHOSPHATE
DECARBOXYLASE

(Escherichia
coli) 		PF00215
(OMPdecase) 		5 THR A  22
TYR A  19
LEU A  10
GLY A  41
LEU A  50
 None
 1.11A 3ijdA-1xbzA:
7.0		 3ijdA-1xbzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 THR A 284
LEU A  27
VAL A  11
GLY A  12
ILE A 110
 None
 0.98A 3ijdA-1ys4A:
undetectable		 3ijdA-1ys4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4r MOLYBDOPTERIN
BIOSYNTHESIS MOG
PROTEIN

(Mycobacterium
tuberculosis) 		PF00994
(MoCF_biosynth) 		5 THR A  68
LEU A  55
VAL A  63
GLY A  62
ILE A 153
 None
 0.85A 3ijdA-2g4rA:
undetectable		 3ijdA-2g4rA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		5 THR A 356
LEU A 360
LEU A 375
ILE A  63
ILE A  75
 None
 1.01A 3ijdA-2g85A:
undetectable		 3ijdA-2g85A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		5 THR A   6
LEU A 191
VAL A 317
LEU A 187
ILE A 309
 None
 1.11A 3ijdA-2gjnA:
8.2		 3ijdA-2gjnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 THR A  14
LEU A  25
VAL A  65
GLY A  64
ILE A  69
 None
 1.09A 3ijdA-2hpiA:
3.8		 3ijdA-2hpiA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		5 THR A 163
LEU A  45
VAL A  54
GLY A  53
ILE A  81
 SAH  A4001 (-4.1A)
None
None
None
None
 1.09A 3ijdA-2iipA:
undetectable		 3ijdA-2iipA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis) 		PF00696
(AA_kinase) 		6 LEU A  16
VAL A  89
GLY A  88
ILE A 127
LEU A  11
ILE A   9
 None
 1.20A 3ijdA-2jjxA:
undetectable		 3ijdA-2jjxA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4h HIV-2 MYRISTOYLATED
MATRIX PROTEIN

(Human
immunodeficiency
virus 2) 		PF00540
(Gag_p17) 		5 LEU A  75
LEU A  21
ILE A  85
LEU A  64
ILE A  60
 None
None
MYR  A   1 ( 3.4A)
None
None
 1.12A 3ijdA-2k4hA:
undetectable		 3ijdA-2k4hA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwv DNA POLYMERASE IOTA

(Mus musculus) 		no annotation 5 LEU A 517
VAL A 500
GLY A 499
GLN A 502
LEU A 491
 None
 1.03A 3ijdA-2kwvA:
undetectable		 3ijdA-2kwvA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		5 LEU A  72
GLY A 114
LEU A 115
LEU A  85
ILE A  86
 None
 1.13A 3ijdA-2p0oA:
9.0		 3ijdA-2p0oA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		5 THR A   9
LEU A  63
VAL A  98
GLY A  97
LEU A  86
 None
 1.01A 3ijdA-2pn1A:
undetectable		 3ijdA-2pn1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q66 POLY(A) POLYMERASE

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		5 LEU A  92
VAL A 201
ILE A 255
LEU A 211
ILE A 214
 None
 1.13A 3ijdA-2q66A:
undetectable		 3ijdA-2q66A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyo O-METHYLTRANSFERASE

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 LEU A 273
VAL A 280
GLY A 287
ILE A 197
LEU A 257
 None
 1.04A 3ijdA-2qyoA:
undetectable		 3ijdA-2qyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		5 LEU A 648
GLY A 623
ILE A 655
LEU A 652
ILE A 318
 None
 0.87A 3ijdA-2rdyA:
undetectable		 3ijdA-2rdyA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 THR A  32
LEU A 343
GLY A 348
ILE A 178
LEU A 357
 None
 1.02A 3ijdA-2wgeA:
undetectable		 3ijdA-2wgeA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm8 MAGNESIUM-DEPENDENT
PHOSPHATASE 1

(Homo sapiens) 		PF12689
(Acid_PPase) 		5 LEU A   8
VAL A 137
GLY A 136
ILE A 102
LEU A 108
 None
 0.85A 3ijdA-2wm8A:
undetectable		 3ijdA-2wm8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		5 TYR A 543
GLY A 557
LEU A 558
GLN A 554
ILE A 241
 None
 1.10A 3ijdA-2wokA:
undetectable		 3ijdA-2wokA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		5 VAL J 302
GLY J 303
LEU J 307
ILE J 332
ILE J 379
 None
None
GOL  J2002 ( 4.1A)
None
None
 1.05A 3ijdA-2wp8J:
undetectable		 3ijdA-2wp8J:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 LEU A 165
VAL A  27
GLY A  26
ILE A  21
LEU A 248
 None
 1.10A 3ijdA-2xkaA:
2.1		 3ijdA-2xkaA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
fragi) 		PF13561
(adh_short_C2) 		5 THR A  10
VAL A 162
GLY A 161
LEU A 113
ILE A  93
 None
None
None
NAD  A 300 (-4.6A)
None
 0.99A 3ijdA-2ztuA:
2.4		 3ijdA-2ztuA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 THR A 262
LEU A 361
VAL A 348
GLY A 347
LEU A 318
 None
 1.00A 3ijdA-3aupA:
undetectable		 3ijdA-3aupA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8j NATURAL KILLER CELL
RECEPTOR LY49C

(Mus musculus) 		PF00059
(Lectin_C)
PF08391
(Ly49) 		5 TYR A 151
VAL A 172
GLY A 171
ILE A 211
ILE A 197
 None
 0.91A 3ijdA-3c8jA:
undetectable		 3ijdA-3c8jA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 352
VAL A 370
GLY A 369
ILE A 122
LEU A 316
 None
 1.10A 3ijdA-3ddmA:
6.3		 3ijdA-3ddmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 THR A 111
LEU A 118
VAL A 229
LEU A 123
ILE A 127
 None
 1.08A 3ijdA-3dj4A:
undetectable		 3ijdA-3dj4A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 LEU A 134
VAL A 142
GLY A 141
LEU A 449
LEU A 176
 None
 1.05A 3ijdA-3e74A:
4.7		 3ijdA-3e74A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE

(Bacillus
subtilis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 LEU A 106
VAL A 111
GLY A 112
ILE A  88
ILE A   6
 None
 1.12A 3ijdA-3egoA:
undetectable		 3ijdA-3egoA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evn OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
agalactiae) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 140
VAL A 223
GLY A 222
ILE A 195
LEU A 190
 None
 1.06A 3ijdA-3evnA:
undetectable		 3ijdA-3evnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f84 CFA/I FIMBRIAL
SUBUNIT B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 THR A  34
LEU A  12
VAL A  16
ILE A  67
LEU A 128
 None
 1.10A 3ijdA-3f84A:
undetectable		 3ijdA-3f84A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f84 CFA/I FIMBRIAL
SUBUNIT B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 THR A 185
LEU A 163
VAL A 167
ILE A 218
LEU A 279
 None
 1.01A 3ijdA-3f84A:
undetectable		 3ijdA-3f84A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 THR A  34
LEU A  12
VAL A  16
ILE A  67
LEU A 128
 None
 1.03A 3ijdA-3f85A:
undetectable		 3ijdA-3f85A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		5 LEU A 186
VAL A 181
LEU A 146
ILE A 174
ILE A 216
 None
 1.09A 3ijdA-3ffhA:
undetectable		 3ijdA-3ffhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffl ANAPHASE-PROMOTING
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF14559
(TPR_19) 		5 THR A 133
LEU A 164
GLY A 147
ILE A 122
GLU A 130
 None
 1.12A 3ijdA-3fflA:
undetectable		 3ijdA-3fflA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffl ANAPHASE-PROMOTING
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF14559
(TPR_19) 		5 THR A 133
LEU A 164
GLY A 147
ILE A 122
LEU A 160
 None
 1.02A 3ijdA-3fflA:
undetectable		 3ijdA-3fflA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv0 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Agrobacterium
fabrum) 		PF13377
(Peripla_BP_3) 		5 LEU A 230
GLY A 237
LEU A 240
ILE A 272
ILE A 290
 None
 1.10A 3ijdA-3gv0A:
undetectable		 3ijdA-3gv0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE

(Deinococcus
radiodurans) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 THR A 360
LEU A 387
GLY A  52
ILE A 235
LEU A  44
 None
 0.98A 3ijdA-3hdyA:
undetectable		 3ijdA-3hdyA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ijd UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF02219
(MTHFR) 		12 THR A  19
TYR A  52
LEU A  54
VAL A 121
GLY A 122
LEU A 134
ILE A 155
ARG A 158
GLN A 183
LEU A 231
ILE A 233
GLU A 280
 C2F  A 314 ( 3.8A)
C2F  A 314 (-3.6A)
None
C2F  A 314 (-4.0A)
C2F  A 314 (-3.5A)
C2F  A 314 ( 4.4A)
None
C2F  A 314 (-3.5A)
C2F  A 314 (-3.4A)
C2F  A 314 (-3.9A)
None
C2F  A 314 (-3.3A)
 0.01A 3ijdA-3ijdA:
52.9		 3ijdA-3ijdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixw HEMOCYANIN AA6 CHAIN

(Androctonus
australis) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 THR A 106
LEU A 517
VAL A 113
GLY A 417
GLN A 111
 None
 1.13A 3ijdA-3ixwA:
undetectable		 3ijdA-3ixwA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 LEU A 165
VAL A  27
GLY A  26
ILE A  21
LEU A 248
 None
 1.05A 3ijdA-3j4sA:
undetectable		 3ijdA-3j4sA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 LEU A1010
GLY A1017
LEU A1020
GLN A1199
ILE A1204
 None
 1.12A 3ijdA-3kg9A:
undetectable		 3ijdA-3kg9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		5 THR C 266
LEU C 287
VAL C 299
GLY C 297
ILE C 325
 None
 1.11A 3ijdA-3mc6C:
undetectable		 3ijdA-3mc6C:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 205
VAL A 226
GLY A 225
LEU A 269
ILE A 150
 None
 1.11A 3ijdA-3mvjA:
undetectable		 3ijdA-3mvjA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00287
(Na_K-ATPase) 		5 TYR B 112
LEU B 153
GLY B 231
ILE B 178
ILE B  80
 None
 1.00A 3ijdA-3n23B:
undetectable		 3ijdA-3n23B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		5 LEU A 316
VAL A 337
GLY A 336
LEU A 380
ILE A 257
 LEU  A 316 ( 0.6A)
VAL  A 337 ( 0.6A)
GLY  A 336 ( 0.0A)
LEU  A 380 ( 0.6A)
ILE  A 257 ( 0.7A)
 1.11A 3ijdA-3o96A:
undetectable		 3ijdA-3o96A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 5 THR B 191
LEU B 252
GLY B 180
LEU B 174
ILE B 173
 None
 1.03A 3ijdA-3ozvB:
undetectable		 3ijdA-3ozvB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		5 THR A 513
ILE A 497
ARG A 446
LEU A 474
ILE A 470
 None
 1.10A 3ijdA-3ozxA:
undetectable		 3ijdA-3ozxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU B  21
VAL B  32
GLY B  34
LEU B   8
ILE B 172
 None
 1.10A 3ijdA-3pcoB:
undetectable		 3ijdA-3pcoB:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qu1 PEPTIDE DEFORMYLASE
2

(Vibrio cholerae) 		PF01327
(Pep_deformylase) 		5 THR A  41
LEU A  92
VAL A  52
GLY A  53
ILE A  58
 None
 1.06A 3ijdA-3qu1A:
undetectable		 3ijdA-3qu1A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		5 GLY A 285
LEU A 286
ILE A 193
ARG A 282
GLN A 190
 None
None
HEC  A1002 (-4.1A)
HEC  A1002 (-3.0A)
None
 1.13A 3ijdA-3ttbA:
undetectable		 3ijdA-3ttbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vba ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
SMALL SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00694
(Aconitase_C) 		5 THR A 134
VAL A  58
GLY A  59
ILE A 105
LEU A 138
 None
 0.85A 3ijdA-3vbaA:
undetectable		 3ijdA-3vbaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdr D-3-HYDROXYBUTYRATE
DEHYDROGENASE

(Alcaligenes
faecalis) 		PF00106
(adh_short) 		5 THR A  10
VAL A 162
GLY A 161
LEU A 113
ILE A  93
 None
None
None
NAI  A 304 ( 4.5A)
None
 1.01A 3ijdA-3vdrA:
2.5		 3ijdA-3vdrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi) 		PF09522
(RE_R_Pab1) 		5 LEU A  78
VAL A 164
GLY A 148
ILE A 206
LEU A 201
 None
ADE  A 301 (-3.8A)
None
None
None
 1.09A 3ijdA-3wazA:
undetectable		 3ijdA-3wazA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi) 		PF09522
(RE_R_Pab1) 		5 TYR A  68
VAL A 164
GLY A 148
ILE A 206
LEU A 201
 ADE  A 301 (-4.2A)
ADE  A 301 (-3.8A)
None
None
None
 0.85A 3ijdA-3wazA:
undetectable		 3ijdA-3wazA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		5 THR A 291
LEU A 124
VAL A 132
GLY A 131
ILE A 408
 None
 1.09A 3ijdA-4arvA:
undetectable		 3ijdA-4arvA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 306
VAL A  82
LEU A 135
LEU A 154
ILE A 153
 None
 1.12A 3ijdA-4cpdA:
undetectable		 3ijdA-4cpdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Synechococcus
elongatus) 		PF13561
(adh_short_C2) 		5 THR A  14
VAL A 165
GLY A 164
LEU A 116
ILE A  96
 None
 1.03A 3ijdA-4dmmA:
undetectable		 3ijdA-4dmmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 122
GLY A 342
ILE A  33
LEU A 351
ILE A 357
 None
 1.04A 3ijdA-4dpkA:
undetectable		 3ijdA-4dpkA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ea1 DEHYDROSQUALENE
SYNTHASE

(Staphylococcus
aureus) 		PF00494
(SQS_PSY) 		6 LEU A 126
VAL A 133
GLY A 132
LEU A 107
LEU A 166
ILE A 167
 None
3RX  A 301 (-4.2A)
None
3RX  A 301 ( 4.9A)
None
None
 1.47A 3ijdA-4ea1A:
undetectable		 3ijdA-4ea1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezd UREA TRANSPORTER 1

(Bos taurus) 		PF03253
(UT) 		5 THR A 314
GLY A 294
LEU A 299
ILE A 244
ILE A 228
 None
 1.05A 3ijdA-4ezdA:
undetectable		 3ijdA-4ezdA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		6 LEU A  25
GLY A 114
LEU A  69
GLN A  56
LEU A  53
ILE A  48
 None
 1.45A 3ijdA-4issA:
undetectable		 3ijdA-4issA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 THR A 243
VAL A 266
GLY A 267
LEU A 273
ILE A 209
 None
 1.01A 3ijdA-4nsxA:
undetectable		 3ijdA-4nsxA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4f INOSITOL
HEXAKISPHOSPHATE
KINASE

(Entamoeba
histolytica) 		PF03770
(IPK) 		5 LEU A 191
VAL A 133
GLY A 132
LEU A 260
ILE A 263
 None
 1.11A 3ijdA-4o4fA:
undetectable		 3ijdA-4o4fA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF00171
(Aldedh) 		5 LEU A 183
VAL A 164
GLY A 163
LEU A 242
ILE A 221
 None
 0.98A 3ijdA-4ou2A:
undetectable		 3ijdA-4ou2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Lactococcus
lactis) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 TYR A  79
GLY A 101
LEU A  84
LEU A  13
ILE A  52
 None
 1.10A 3ijdA-4pczA:
undetectable		 3ijdA-4pczA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)

(Methylobacterium
extorquens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A  82
GLY A 158
ILE A 191
LEU A 166
ILE A 169
 None
 1.10A 3ijdA-4px1A:
undetectable		 3ijdA-4px1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		5 THR A 295
LEU A 178
GLY A 185
ILE A 389
GLU A 316
 None
 1.00A 3ijdA-4r27A:
9.2		 3ijdA-4r27A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 THR A 122
LEU A 181
VAL A 230
ILE A 244
ILE A 283
 None
 1.11A 3ijdA-4rybA:
undetectable		 3ijdA-4rybA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Synechocystis
sp. PCC 6803) 		PF13561
(adh_short_C2) 		5 THR A  12
VAL A 163
GLY A 162
LEU A 114
ILE A  94
 None
 1.03A 3ijdA-4rzhA:
2.2		 3ijdA-4rzhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		5 VAL A  35
GLY A 108
LEU A 107
ILE A  39
ILE A 191
 None
 1.04A 3ijdA-4twfA:
undetectable		 3ijdA-4twfA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7h CARBONYL REDUCTASE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		5 THR A 124
LEU A  66
GLY A  95
ILE A  19
ILE A  12
 None
 0.96A 3ijdA-4w7hA:
undetectable		 3ijdA-4w7hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		6 LEU A  80
GLY A  20
LEU A  23
ILE A  15
LEU A 159
ILE A 339
 None
None
None
FAD  A 401 (-3.9A)
None
FAD  A 401 (-3.8A)
 1.43A 3ijdA-4yshA:
undetectable		 3ijdA-4yshA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		5 THR A 241
LEU A   8
GLY A 214
ILE A 158
LEU A 245
 None
 0.98A 3ijdA-4zaaA:
undetectable		 3ijdA-4zaaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbz URACIL-DNA
GLYCOSYLASE

(Sulfurisphaera
tokodaii) 		PF03167
(UDG) 		5 VAL A  40
GLY A  41
LEU A 121
GLN A 109
ILE A   7
 None
 1.05A 3ijdA-4zbzA:
undetectable		 3ijdA-4zbzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 LEU A 218
VAL A 227
GLY A 226
LEU A 307
LEU A 275
 None
 1.02A 3ijdA-4zc0A:
undetectable		 3ijdA-4zc0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmu DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF)
PF01590
(GAF) 		6 LEU A 147
VAL A  44
GLY A  43
ILE A  63
LEU A 129
ILE A  49
 None
 1.35A 3ijdA-4zmuA:
undetectable		 3ijdA-4zmuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqq TWO PORE CALCIUM
CHANNEL PROTEIN 1

(Arabidopsis
thaliana) 		PF00520
(Ion_trans) 		5 THR A 485
TYR A 486
GLY A 495
ARG A 543
ILE A 436
 None
 1.11A 3ijdA-5dqqA:
undetectable		 3ijdA-5dqqA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2c XAA-PRO DIPEPTIDASE

(Mycobacterium
tuberculosis) 		PF01321
(Creatinase_N) 		5 VAL A  92
GLY A  93
ILE A  14
LEU A  23
ILE A  24
 None
 0.78A 3ijdA-5e2cA:
undetectable		 3ijdA-5e2cA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd4 COMR

(Streptococcus
suis) 		PF13560
(HTH_31) 		5 LEU A 211
VAL A 169
ILE A 221
LEU A 215
ILE A 234
 None
 1.13A 3ijdA-5fd4A:
undetectable		 3ijdA-5fd4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A

(Bacillus
subtilis;
Bacillus
subtilis;
Bacillus
subtilis) 		PF02463
(SMC_N)
PF02463
(SMC_N)
PF02616
(SMC_ScpA) 		6 VAL B1163
GLY B1162
LEU C 221
ILE B1147
LEU A   6
ILE A  44
 None
 1.20A 3ijdA-5h67B:
undetectable		 3ijdA-5h67B:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LEU A  25
GLY A 114
LEU A  69
GLN A  56
LEU A  53
ILE A  48
 None
 1.45A 3ijdA-5i8iA:
undetectable		 3ijdA-5i8iA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 311
LEU A 123
ILE A 157
LEU A 136
ILE A 139
 None
 1.09A 3ijdA-5idnA:
undetectable		 3ijdA-5idnA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		5 GLY A 548
LEU A 551
ILE A 531
LEU A 417
ILE A 419
 None
EDO  A 601 (-3.8A)
None
None
None
 1.09A 3ijdA-5il0A:
undetectable		 3ijdA-5il0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lng PUTATIVE FML
FIMBRIAL ADHESIN
FMLD

(Escherichia
coli) 		PF09160
(FimH_man-bind) 		5 VAL A 117
GLY A 116
ILE A  26
LEU A  67
ILE A 108
 None
 1.09A 3ijdA-5lngA:
undetectable		 3ijdA-5lngA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lox PEPTIDASE

(Pseudomonas
aeruginosa) 		no annotation 5 THR A  89
LEU A  85
VAL A 113
GLY A 114
LEU A 124
 None
 0.99A 3ijdA-5loxA:
undetectable		 3ijdA-5loxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 5 LEU A 301
GLY A 415
LEU A 463
ILE A 455
LEU A 317
 None
 1.02A 3ijdA-5oatA:
undetectable		 3ijdA-5oatA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te9 RESPONSE REGULATOR
RECEIVER PROTEIN

(Paraburkholderia
phymatum) 		PF00072
(Response_reg) 		5 THR A  25
LEU A  14
GLY A  64
ILE A 135
ILE A 119
 None
 0.87A 3ijdA-5te9A:
undetectable		 3ijdA-5te9A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A 209
VAL A  55
GLY A  54
LEU A 229
ILE A 153
 None
 1.09A 3ijdA-5u24A:
undetectable		 3ijdA-5u24A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 5 LEU A 298
VAL A 314
GLY A 294
LEU A 289
ILE A 323
 None
 1.08A 3ijdA-5wypA:
undetectable		 3ijdA-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF02463
(SMC_N)
no annotation 		6 VAL A1143
GLY A1142
LEU C 188
ILE A1127
LEU A   7
ILE A  46
 None
 1.40A 3ijdA-5xnsA:
undetectable		 3ijdA-5xnsA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 5 THR A  46
VAL A 135
GLY A 134
LEU A 103
ILE A  69
 None
 0.92A 3ijdA-6bk1A:
2.6		 3ijdA-6bk1A:
undetectable