SIMILAR PATTERNS OF AMINO ACIDS FOR 3IHZ_A_FK5A501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 ASP A 136
GLY A 228
SER A 197
ILE A 229
 None
 0.67A 3ihzB-1do5A:
undetectable		 3ihzB-1do5A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elp GAMMA-D CRYSTALLIN

(Bos taurus) 		PF00030
(Crystall) 		4 TYR A   6
PHE A  11
GLY A   1
SER A  19
 None
 0.85A 3ihzB-1elpA:
undetectable		 3ihzB-1elpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 TYR A 195
GLY A 147
SER A 150
ILE A 149
 None
 0.79A 3ihzB-1eovA:
undetectable		 3ihzB-1eovA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 PHE A 153
TRP A 162
TYR A 185
GLY A 191
ILE A 194
 None
 1.31A 3ihzB-1fd9A:
17.6		 3ihzB-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 PHE A 153
TRP A 162
TYR A 185
GLY A 192
ILE A 194
 None
 1.40A 3ihzB-1fd9A:
17.6		 3ihzB-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 TYR A 131
ASP A 142
TRP A 162
TYR A 185
GLY A 191
ILE A 194
 None
 0.76A 3ihzB-1fd9A:
17.6		 3ihzB-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 131
TRP A 162
TYR A 185
GLY A 192
ILE A 194
 None
 0.92A 3ihzB-1fd9A:
17.6		 3ihzB-1fd9A:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		6 TYR A  26
ASP A  37
PHE A  46
TRP A  59
TYR A  82
ILE A  91
 None
 0.55A 3ihzB-1fkkA:
19.7		 3ihzB-1fkkA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		5 PHE A 114
TRP A 123
TYR A 146
GLY A 152
ILE A 155
 None
 1.35A 3ihzB-1jvwA:
16.2		 3ihzB-1jvwA:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		5 PHE A 114
TRP A 123
TYR A 146
GLY A 153
ILE A 155
 None
 1.08A 3ihzB-1jvwA:
16.2		 3ihzB-1jvwA:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		6 TYR A  92
ASP A 103
TRP A 123
TYR A 146
GLY A 153
ILE A 155
 None
 0.47A 3ihzB-1jvwA:
16.2		 3ihzB-1jvwA:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		4 ASP A 245
GLY A 240
SER A 242
ILE A 284
 None
 0.83A 3ihzB-1ka0A:
undetectable		 3ihzB-1ka0A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		4 TYR A  57
PHE A  77
TRP A  90
ILE A 122
 None
 0.87A 3ihzB-1kt1A:
17.6		 3ihzB-1kt1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4j A6 GENE PRODUCT

(Mus musculus) 		PF00241
(Cofilin_ADF) 		4 TYR A 134
ASP A 119
GLY A 115
ILE A 117
 None
 0.88A 3ihzB-1m4jA:
undetectable		 3ihzB-1m4jA:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
TRP A  90
TYR A 113
ILE A 122
 None
 0.48A 3ihzB-1n1aA:
21.1		 3ihzB-1n1aA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A 135
TRP A 175
TYR A 198
ILE A 208
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.4A)
RAP  A 225 (-4.6A)
RAP  A 225 ( 4.9A)
 0.49A 3ihzB-1pbkA:
18.2		 3ihzB-1pbkA:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 146
ASP A 157
TRP A 177
TYR A 200
ILE A 208
 None
 0.57A 3ihzB-1q6hA:
17.1		 3ihzB-1q6hA:
26.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		6 TYR A  40
ASP A  51
PHE A  60
TRP A  73
TYR A  96
ILE A 105
 None
 0.34A 3ihzB-1r9hA:
22.9		 3ihzB-1r9hA:
47.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1)
PF13177
(DNA_pol3_delta2) 		4 TYR E 287
GLY A 624
SER A 622
ILE A 621
 None
 0.90A 3ihzB-1sxjE:
undetectable		 3ihzB-1sxjE:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twl INORGANIC
PYROPHOSPHATASE

(Pyrococcus
furiosus) 		PF00719
(Pyrophosphatase) 		4 ASP A  43
TYR A  52
GLY A  57
ILE A  23
 None
 0.73A 3ihzB-1twlA:
undetectable		 3ihzB-1twlA:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		5 TYR A  37
ASP A  48
TRP A  70
TYR A  99
ILE A 113
 None
 0.34A 3ihzB-1u79A:
19.2		 3ihzB-1u79A:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		4 TYR A  26
ASP A  37
GLY A  89
ILE A  91
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
None
None
 0.88A 3ihzB-1yatA:
21.0		 3ihzB-1yatA:
39.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		5 TYR A  26
PHE A  46
TRP A  59
TYR A  82
ILE A  91
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.6A)
FK5  A 108 ( 4.7A)
None
 0.38A 3ihzB-1yatA:
21.0		 3ihzB-1yatA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2do8 UPF0301 PROTEIN
HD_1794

([Haemophilus]
ducreyi) 		PF02622
(DUF179) 		4 PHE A  21
GLY A 175
SER A 177
ILE A 176
 None
 0.73A 3ihzB-2do8A:
undetectable		 3ihzB-2do8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 ASP A 386
TYR A 316
GLY A 367
SER A 364
 None
 0.76A 3ihzB-2gjxA:
undetectable		 3ihzB-2gjxA:
14.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		4 TYR A  27
PHE A  47
TRP A  60
ILE A  92
 None
 0.79A 3ihzB-2lpvA:
16.6		 3ihzB-2lpvA:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr4 CONSERVED
HYPOTHETICAL PROTEIN

(Methanosarcina
mazei) 		PF04289
(DUF447) 		4 TRP A 118
GLY A  47
SER A  30
ILE A  32
 None
FMN  A 401 (-3.6A)
None
None
 0.89A 3ihzB-2nr4A:
undetectable		 3ihzB-2nr4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oc6 YDHG PROTEIN

(Bacillus
subtilis) 		PF08818
(DUF1801) 		4 ASP A  76
TYR A  85
GLY A  82
ILE A  78
 None
 0.86A 3ihzB-2oc6A:
undetectable		 3ihzB-2oc6A:
25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
ASP A  67
PHE A  76
TRP A  89
ILE A 121
 PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.7A)
None
 0.86A 3ihzB-2pbcA:
15.4		 3ihzB-2pbcA:
42.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
ASP A  67
TRP A  89
TYR A 112
ILE A 121
 PEG  A 201 (-4.4A)
None
PEG  A 201 (-3.7A)
None
None
 0.70A 3ihzB-2pbcA:
15.4		 3ihzB-2pbcA:
42.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 PHE A  77
GLY A 128
SER A 164
ILE A 163
 None
 0.77A 3ihzB-2pt6A:
undetectable		 3ihzB-2pt6A:
16.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		4 TYR A  55
TRP A  86
TYR A 109
GLY A 116
 RAP  A 138 (-2.6A)
RAP  A 138 (-2.3A)
RAP  A 138 (-3.8A)
None
 0.68A 3ihzB-2vcdA:
14.9		 3ihzB-2vcdA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		5 TYR A  44
PHE A  65
TRP A  78
TYR A 101
ILE A 110
 FK5  A 501 (-4.1A)
FK5  A 501 (-4.1A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.7A)
None
 0.40A 3ihzB-2vn1A:
24.1		 3ihzB-2vn1A:
80.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		5 TYR A  44
TRP A  78
TYR A 101
GLY A 107
ILE A 110
 FK5  A 501 (-4.1A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.7A)
None
None
 0.80A 3ihzB-2vn1A:
24.1		 3ihzB-2vn1A:
80.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 278
ASP A 218
GLY A 243
ILE A 247
 None
 0.89A 3ihzB-2x50A:
undetectable		 3ihzB-2x50A:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		6 TYR A  33
ASP A  44
PHE A  53
TRP A  66
GLY A  96
ILE A  98
 None
 0.65A 3ihzB-2y78A:
19.7		 3ihzB-2y78A:
38.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		6 TYR A  33
ASP A  44
PHE A  53
TRP A  66
TYR A  89
GLY A  96
 None
 0.59A 3ihzB-2y78A:
19.7		 3ihzB-2y78A:
38.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		4 PHE A 185
GLY A  54
SER A  50
ILE A  53
 None
 0.89A 3ihzB-2ywdA:
undetectable		 3ihzB-2ywdA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ASP A 278
GLY A 307
SER A 309
ILE A 276
 None
None
FAD  A 622 ( 4.4A)
None
 0.69A 3ihzB-3cp8A:
undetectable		 3ihzB-3cp8A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 305
ASP A 126
PHE A  18
GLY A 255
 None
 0.78A 3ihzB-3fhlA:
undetectable		 3ihzB-3fhlA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		4 TYR A  74
ASP A 473
GLY A 452
SER A 408
 None
 0.87A 3ihzB-3foaA:
undetectable		 3ihzB-3foaA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A 457
GLY A 180
SER A 322
ILE A 321
 HBX  A 530 (-4.3A)
None
None
None
 0.84A 3ihzB-3gdnA:
undetectable		 3ihzB-3gdnA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir3 3-HYDROXYACYL-THIOES
TER DEHYDRATASE 2

(Homo sapiens) 		PF01575
(MaoC_dehydratas) 		4 PHE A  48
GLY A 156
SER A 113
ILE A 112
 None
 0.89A 3ihzB-3ir3A:
undetectable		 3ihzB-3ir3A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 TYR U  74
ASP U 473
GLY U 452
SER U 408
 None
 0.87A 3ihzB-3j2nU:
undetectable		 3ihzB-3j2nU:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lat BIFUNCTIONAL
AUTOLYSIN

(Staphylococcus
epidermidis) 		PF01510
(Amidase_2) 		4 PHE A  84
GLY A 173
SER A 169
ILE A 168
 None
 0.92A 3ihzB-3latA:
undetectable		 3ihzB-3latA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
TRP A  90
TYR A 113
ILE A 122
 None
 0.59A 3ihzB-3o5dA:
20.9		 3ihzB-3o5dA:
29.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
PHE A  77
TRP A  90
ILE A 122
 None
 0.59A 3ihzB-3o5eA:
21.3		 3ihzB-3o5eA:
44.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
PHE A  77
TYR A 113
ILE A 122
 None
 0.41A 3ihzB-3o5eA:
21.3		 3ihzB-3o5eA:
44.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		8 TYR A  43
ASP A  55
PHE A  64
TRP A  77
TYR A 100
GLY A 106
SER A 108
ILE A 109
 None
 0.53A 3ihzB-3pa7A:
25.5		 3ihzB-3pa7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q46 TT-IPPASE

(Thermococcus
thioreducens) 		PF00719
(Pyrophosphatase) 		4 ASP A  43
TYR A  52
GLY A  57
ILE A  23
 EPE  A 309 ( 4.3A)
None
None
None
 0.78A 3ihzB-3q46A:
undetectable		 3ihzB-3q46A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6y ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1) 		4 ASP A  93
GLY A 100
SER A 102
ILE A 103
 ASP  A  93 ( 0.5A)
GLY  A 100 ( 0.0A)
SER  A 102 ( 0.0A)
ILE  A 103 ( 0.6A)
 0.69A 3ihzB-3r6yA:
undetectable		 3ihzB-3r6yA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		4 PHE A 178
TRP A 166
GLY A  57
ILE A  59
 None
 0.81A 3ihzB-3rrwA:
undetectable		 3ihzB-3rrwA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 TYR A 809
GLY A1013
SER A1060
ILE A1014
 None
 0.79A 3ihzB-3s5kA:
undetectable		 3ihzB-3s5kA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		4 ASP A  44
GLY A 138
SER A 140
ILE A 139
 None
 0.77A 3ihzB-3vvlA:
undetectable		 3ihzB-3vvlA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		4 TYR A  51
GLY A  16
SER A  14
ILE A  15
 None
 0.92A 3ihzB-3wj9A:
undetectable		 3ihzB-3wj9A:
16.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		4 TYR A 313
ASP A 324
PHE A 332
TRP A 345
 None
 0.63A 3ihzB-4bf8A:
17.4		 3ihzB-4bf8A:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TRP A  88
TYR A 111
GLY A 117
ILE A 119
 None
 0.88A 3ihzB-4dipA:
18.0		 3ihzB-4dipA:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A  52
TRP A  88
TYR A 111
ILE A 119
 None
 0.50A 3ihzB-4dipA:
18.0		 3ihzB-4dipA:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1

(Danio rerio) 		PF00079
(Serpin) 		4 TYR A 374
GLY A 138
SER A 141
ILE A 140
 None
 0.89A 3ihzB-4dteA:
undetectable		 3ihzB-4dteA:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		6 TYR A  33
PHE A  53
TRP A  66
TYR A  89
GLY A  95
ILE A  98
 FK5  A 201 ( 3.9A)
FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.7A)
None
None
 0.61A 3ihzB-4dz3A:
20.4		 3ihzB-4dz3A:
40.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9k HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF14717
(DUF4465) 		4 ASP A 145
TYR A  27
GLY A  72
ILE A  73
 None
 0.78A 3ihzB-4e9kA:
undetectable		 3ihzB-4e9kA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecp INORGANIC
PYROPHOSPHATASE

(Mycobacterium
leprae) 		PF00719
(Pyrophosphatase) 		4 ASP A  29
TYR A  38
GLY A  43
ILE A   9
 None
 0.77A 3ihzB-4ecpA:
undetectable		 3ihzB-4ecpA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 TYR A  44
PHE A  43
GLY A 162
ILE A  75
 None
 0.84A 3ihzB-4ewtA:
undetectable		 3ihzB-4ewtA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		4 ASP A 155
GLY A 180
SER A 182
ILE A 157
 None
 0.85A 3ihzB-4g09A:
undetectable		 3ihzB-4g09A:
12.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A  26
ASP A  37
PHE A  46
TYR A  82
 None
 0.51A 3ihzB-4iqcA:
19.6		 3ihzB-4iqcA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A  26
PHE A  46
TYR A  82
ILE A  91
 None
 0.66A 3ihzB-4iqcA:
19.6		 3ihzB-4iqcA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgf GAMMA-CRYSTALLIN D

(Homo sapiens) 		PF00030
(Crystall) 		4 TYR A   6
PHE A  11
GLY A   1
SER A  19
 None
 0.64A 3ihzB-4jgfA:
undetectable		 3ihzB-4jgfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhs BETA-2-GLYCOPROTEIN
1

(Homo sapiens) 		PF00084
(Sushi)
PF09014
(Sushi_2) 		4 TYR A 275
ASP A 294
GLY A 318
ILE A 320
 None
 0.92A 3ihzB-4jhsA:
undetectable		 3ihzB-4jhsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
TRP A  90
TYR A 113
ILE A 122
 None
None
None
DMS  A 304 ( 4.0A)
None
None
 0.46A 3ihzB-4lawA:
21.1		 3ihzB-4lawA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		4 ASP A  15
GLY A  51
SER A  59
ILE A  58
 None
 0.76A 3ihzB-4ldnA:
undetectable		 3ihzB-4ldnA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		4 ASP A 183
GLY A 143
SER A 169
ILE A 168
 None
 0.75A 3ihzB-4m0dA:
undetectable		 3ihzB-4m0dA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C)
PF13499
(EF-hand_7) 		5 TYR A  33
TRP A  69
TYR A  92
GLY A  98
ILE A 100
 None
 0.83A 3ihzB-4mspA:
17.9		 3ihzB-4mspA:
24.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
PHE A  76
TRP A  89
TYR A 112
ILE A 121
 FK5  A 201 (-4.1A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.5A)
None
 0.40A 3ihzB-4nnrA:
15.5		 3ihzB-4nnrA:
39.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ASP A 477
TYR A 521
GLY A 483
ILE A 479
 None
 0.91A 3ihzB-4pvgA:
undetectable		 3ihzB-4pvgA:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
TRP A  90
TYR A 113
ILE A 122
 None
 0.58A 3ihzB-4r0xA:
22.5		 3ihzB-4r0xA:
50.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 PHE A  77
GLY A 128
SER A 164
ILE A 163
 None
 0.78A 3ihzB-4uoeA:
undetectable		 3ihzB-4uoeA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		4 TYR A  48
ASP A 307
GLY A  87
SER A  83
 None
 0.87A 3ihzB-4yhsA:
undetectable		 3ihzB-4yhsA:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		4 TYR C  36
ASP C  56
PHE C  64
GLY C 107
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
EDO  C 204 (-3.6A)
 0.59A 3ihzB-5b8iC:
18.3		 3ihzB-5b8iC:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		5 TYR C  36
PHE C  64
TRP C  77
TYR C 100
ILE C 109
 FK5  C 201 (-4.1A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
 0.48A 3ihzB-5b8iC:
18.3		 3ihzB-5b8iC:
38.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		4 ASP A1376
TYR A1245
SER A1898
ILE A1897
 None
None
OGA  A2001 (-2.7A)
None
 0.89A 3ihzB-5deuA:
undetectable		 3ihzB-5deuA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 ASP A 477
TYR A 521
GLY A 483
ILE A 479
 None
 0.89A 3ihzB-5i6vA:
undetectable		 3ihzB-5i6vA:
14.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  26
ASP A  37
PHE A  46
TRP A  59
TYR A  82
 None
 0.41A 3ihzB-5i7pA:
18.1		 3ihzB-5i7pA:
30.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  26
ASP A  37
PHE A  46
TRP A  59
TYR A  82
 None
 0.55A 3ihzB-5i7qA:
18.3		 3ihzB-5i7qA:
31.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		4 TYR A  30
ASP A  41
PHE A  50
ILE A 105
 None
 0.88A 3ihzB-5i98A:
18.0		 3ihzB-5i98A:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		6 TYR A  30
ASP A  41
PHE A  50
TRP A  63
TYR A  97
ILE A 106
 None
 0.51A 3ihzB-5i98A:
18.0		 3ihzB-5i98A:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		6 TYR A  27
ASP A  38
PHE A  47
TRP A  60
TYR A  83
ILE A  92
 None
 0.45A 3ihzB-5j6eA:
19.8		 3ihzB-5j6eA:
42.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd7 KINESIN-LIKE PROTEIN
KIF20A

(Mus musculus) 		PF00225
(Kinesin) 		4 TYR C 158
PHE C 499
GLY C 427
ILE C 429
 None
 0.87A 3ihzB-5nd7C:
undetectable		 3ihzB-5nd7C:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 4 TYR A 217
PHE A 215
TYR A 179
ILE A 204
 None
 0.71A 3ihzB-5o8rA:
undetectable		 3ihzB-5o8rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 5 TYR A  33
ASP A  44
PHE A  53
GLY A  96
ILE A  98
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.9A)
None
8ZV  A 201 ( 4.8A)
 0.84A 3ihzB-5v8tA:
20.5		 3ihzB-5v8tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 6 TYR A  33
PHE A  53
TRP A  66
TYR A  89
GLY A  96
ILE A  98
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.3A)
8ZV  A 201 (-4.6A)
None
8ZV  A 201 ( 4.8A)
 0.69A 3ihzB-5v8tA:
20.5		 3ihzB-5v8tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TYR A  98
GLY A 100
SER A 102
ILE A 101
 None
 0.83A 3ihzB-5vniA:
undetectable		 3ihzB-5vniA:
10.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		5 ASP A 158
PHE A 166
TRP A 175
TYR A 198
ILE A 207
 TLA  A 301 (-3.7A)
TLA  A 301 ( 4.6A)
TLA  A 301 (-3.4A)
None
None
 1.23A 3ihzB-5xb0A:
16.4		 3ihzB-5xb0A:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		5 TYR A 147
ASP A 158
TRP A 175
TYR A 198
ILE A 207
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
None
None
 0.64A 3ihzB-5xb0A:
16.4		 3ihzB-5xb0A:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6atk SPIKE GLYCOPROTEIN

(Human
coronavirus
229E) 		no annotation 4 ASP E 342
GLY E 424
SER E 344
ILE E 425
 None
 0.87A 3ihzB-6atkE:
undetectable		 3ihzB-6atkE:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 4 TYR A  38
ASP A  49
PHE A  58
GLY A 101
 None
 0.64A 3ihzB-6b4pA:
22.0		 3ihzB-6b4pA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 5 TYR A  38
ASP A  49
PHE A  58
TRP A  71
ILE A 103
 None
 0.75A 3ihzB-6b4pA:
22.0		 3ihzB-6b4pA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 5 TYR A  38
PHE A  58
TRP A  71
TYR A  94
ILE A 103
 None
 0.61A 3ihzB-6b4pA:
22.0		 3ihzB-6b4pA:
42.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 4 ASP A 425
TYR A 273
GLY A  85
ILE A 192
 FMT  A 601 (-3.7A)
None
None
None
 0.73A 3ihzB-6begA:
undetectable		 3ihzB-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 8

(Ficedula
albicollis) 		no annotation 4 TYR A 497
PHE A 531
SER A 577
ILE A 580
 None
 0.85A 3ihzB-6bpqA:
undetectable		 3ihzB-6bpqA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 4 ASP A 226
GLY A 218
SER A 233
ILE A 232
 None
 0.89A 3ihzB-6c54A:
undetectable		 3ihzB-6c54A:
21.93