SIMILAR PATTERNS OF AMINO ACIDS FOR 3IHZ_A_FK5A501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eom ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F3

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		5 ASP A  34
VAL A 284
ILE A 271
TYR A 274
ILE A  29
 None
 1.41A 3ihzA-1eomA:
undetectable		 3ihzA-1eomA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
 None
 1.10A 3ihzA-1fd9A:
17.1		 3ihzA-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		8 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
 None
 0.50A 3ihzA-1fd9A:
17.1		 3ihzA-1fd9A:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		10 TYR A  26
ASP A  37
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  91
PHE A  99
 None
 0.48A 3ihzA-1fkkA:
19.3		 3ihzA-1fkkA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4s RIBONUCLEASE III

(Aquifex
aeolicus) 		PF14622
(Ribonucleas_3_3) 		5 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.43A 3ihzA-1i4sA:
undetectable		 3ihzA-1i4sA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		5 TYR A 251
PHE A 253
VAL A 263
ILE A 266
ILE A  34
 None
 1.29A 3ihzA-1j0aA:
undetectable		 3ihzA-1j0aA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		6 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.99A 3ihzA-1jvwA:
15.7		 3ihzA-1jvwA:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		8 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.46A 3ihzA-1jvwA:
15.7		 3ihzA-1jvwA:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		8 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.56A 3ihzA-1jvwA:
15.7		 3ihzA-1jvwA:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		7 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
 0.81A 3ihzA-1kt1A:
17.0		 3ihzA-1kt1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 ASP A 101
ARG A   8
PHE A 106
VAL A 188
ILE A 140
 None
 1.37A 3ihzA-1lnlA:
undetectable		 3ihzA-1lnlA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md7 C1R COMPLEMENT
SERINE PROTEASE

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 TYR A 568
PHE A 567
VAL A 643
ILE A 656
PHE A 621
 None
 1.13A 3ihzA-1md7A:
undetectable		 3ihzA-1md7A:
15.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.53A 3ihzA-1n1aA:
20.9		 3ihzA-1n1aA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A 135
ASP A 146
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 208
PHE A 216
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-3.5A)
RAP  A 225 (-3.9A)
RAP  A 225 (-3.4A)
RAP  A 225 (-4.6A)
RAP  A 225 ( 4.9A)
None
 0.42A 3ihzA-1pbkA:
18.1		 3ihzA-1pbkA:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 PHE A 168
ILE A 174
TRP A 177
TYR A 200
ILE A 208
PHE A 216
 None
 1.26A 3ihzA-1q6hA:
16.6		 3ihzA-1q6hA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		9 TYR A 146
ASP A 157
ARG A 162
VAL A 173
ILE A 174
TRP A 177
TYR A 200
ILE A 208
PHE A 216
 None
 0.56A 3ihzA-1q6hA:
16.6		 3ihzA-1q6hA:
26.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		10 TYR A  40
ASP A  51
ARG A  56
PHE A  60
VAL A  69
ILE A  70
TRP A  73
TYR A  96
ILE A 105
PHE A 113
 None
 0.57A 3ihzA-1r9hA:
22.1		 3ihzA-1r9hA:
47.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc7 RIBONUCLEASE III

(Aquifex
aeolicus) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		5 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.35A 3ihzA-1rc7A:
undetectable		 3ihzA-1rc7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.06A 3ihzA-1ry2A:
undetectable		 3ihzA-1ry2A:
10.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		8 TYR A  37
ASP A  48
VAL A  66
ILE A  67
TRP A  70
TYR A  99
ILE A 113
PHE A 121
 None
 0.42A 3ihzA-1u79A:
18.6		 3ihzA-1u79A:
40.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqs HYPOTHETICAL PROTEIN
AGR_L_1239

(Agrobacterium
fabrum) 		PF07978
(NIPSNAP) 		5 ARG A  67
VAL A  52
ILE A  51
TYR A  18
ILE A  83
 None
 1.42A 3ihzA-1vqsA:
undetectable		 3ihzA-1vqsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzn SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		5 ASP A 144
VAL A  23
ILE A  27
ILE A  33
PHE A 112
 None
 1.43A 3ihzA-1wznA:
undetectable		 3ihzA-1wznA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		10 TYR A  26
ASP A  37
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  91
PHE A  99
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 (-3.7A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.4A)
FK5  A 108 ( 3.7A)
FK5  A 108 ( 3.6A)
FK5  A 108 ( 4.7A)
None
None
 0.30A 3ihzA-1yatA:
20.8		 3ihzA-1yatA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap6 HYPOTHETICAL PROTEIN
ATU4242

(Agrobacterium
fabrum) 		PF07978
(NIPSNAP) 		5 ARG A  67
VAL A  52
ILE A  51
TYR A  18
ILE A  83
 None
 1.40A 3ihzA-2ap6A:
undetectable		 3ihzA-2ap6A:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		5 TYR A  27
ILE A  57
TRP A  60
ILE A  92
PHE A 100
 None
 1.20A 3ihzA-2lpvA:
16.5		 3ihzA-2lpvA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		5 TYR A  27
PHE A  47
ILE A  57
TRP A  60
ILE A  92
 None
 0.96A 3ihzA-2lpvA:
16.5		 3ihzA-2lpvA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		5 TYR A  27
VAL A  56
ILE A  57
TRP A  60
ILE A  92
 None
 0.85A 3ihzA-2lpvA:
16.5		 3ihzA-2lpvA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		6 PHE A  78
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
 None
PEG  A 201 (-3.8A)
PEG  A 201 (-3.7A)
None
None
None
 1.45A 3ihzA-2pbcA:
15.3		 3ihzA-2pbcA:
42.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
 PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
PEG  A 201 (-3.8A)
PEG  A 201 (-3.7A)
None
None
None
 0.75A 3ihzA-2pbcA:
15.3		 3ihzA-2pbcA:
42.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 ASP A  66
VAL A  82
ILE A  83
TRP A  86
PHE A 126
 RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 ( 4.7A)
 0.75A 3ihzA-2vcdA:
14.7		 3ihzA-2vcdA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A  55
ASP A  66
VAL A  82
ILE A  83
TRP A  86
 RAP  A 138 (-2.6A)
RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
 0.72A 3ihzA-2vcdA:
14.7		 3ihzA-2vcdA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A  55
VAL A  82
ILE A  83
TRP A  86
TYR A 109
 RAP  A 138 (-2.6A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 (-3.8A)
 0.56A 3ihzA-2vcdA:
14.7		 3ihzA-2vcdA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 VAL A  82
ILE A  83
TRP A  86
TYR A 109
PHE A 126
 RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 (-3.8A)
RAP  A 138 ( 4.7A)
 0.89A 3ihzA-2vcdA:
14.7		 3ihzA-2vcdA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		10 TYR A  44
ASP A  56
ARG A  61
PHE A  65
VAL A  74
ILE A  75
TRP A  78
TYR A 101
ILE A 110
PHE A 118
 FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-3.9A)
FK5  A 501 (-4.1A)
FK5  A 501 (-3.5A)
FK5  A 501 (-4.3A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.7A)
None
FK5  A 501 (-4.8A)
 0.44A 3ihzA-2vn1A:
24.1		 3ihzA-2vn1A:
80.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		10 TYR A  33
ASP A  44
ARG A  49
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 None
 0.62A 3ihzA-2y78A:
19.5		 3ihzA-2y78A:
38.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b7x FK506-BINDING
PROTEIN 6

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  61
ASP A  73
TYR A 118
ILE A 127
PHE A 135
 None
 0.92A 3ihzA-3b7xA:
16.5		 3ihzA-3b7xA:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		5 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
 None
 1.27A 3ihzA-3focA:
undetectable		 3ihzA-3focA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9f PUTATIVE TYPE 11
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF08241
(Methyltransf_11) 		5 TYR A 147
ASP A 126
PHE A 151
VAL A 122
ILE A 123
 None
 1.34A 3ihzA-3i9fA:
undetectable		 3ihzA-3i9fA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibp CHROMOSOME PARTITION
PROTEIN MUKB

(Escherichia
coli) 		PF16330
(MukB_hinge) 		5 TYR A 690
ASP A 746
PHE A 778
ILE A 737
PHE A 744
 None
 1.45A 3ihzA-3ibpA:
undetectable		 3ihzA-3ibpA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		5 ARG A 685
VAL A 712
ILE A 701
TYR A 745
ILE A 674
 None
 1.30A 3ihzA-3j9dA:
undetectable		 3ihzA-3j9dA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		5 ASP A 679
VAL A 712
ILE A 701
TYR A 745
ILE A 674
 None
 1.38A 3ihzA-3j9dA:
undetectable		 3ihzA-3j9dA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		5 ASP A 130
ARG A  79
VAL A 119
ILE A 115
ILE A 132
 None
 1.45A 3ihzA-3msgA:
undetectable		 3ihzA-3msgA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus) 		PF00704
(Glyco_hydro_18) 		5 TYR A  82
PHE A  88
VAL A  64
ILE A  62
TRP A  40
 None
 1.39A 3ihzA-3n11A:
undetectable		 3ihzA-3n11A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.77A 3ihzA-3o5dA:
20.3		 3ihzA-3o5dA:
29.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.82A 3ihzA-3o5eA:
20.7		 3ihzA-3o5eA:
44.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		10 TYR A  43
ASP A  55
ARG A  60
PHE A  64
VAL A  73
ILE A  74
TRP A  77
TYR A 100
ILE A 109
PHE A 117
 None
 0.54A 3ihzA-3pa7A:
25.1		 3ihzA-3pa7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 TYR A 569
VAL A 210
ILE A 224
TYR A 226
ILE A 200
 None
 1.25A 3ihzA-3um6A:
undetectable		 3ihzA-3um6A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Thermosynechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ASP A  50
ARG A  11
PHE A   9
ILE A  61
ILE A  55
 None
 1.41A 3ihzA-3zdfA:
undetectable		 3ihzA-3zdfA:
17.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 ASP A 324
VAL A 341
ILE A 342
TRP A 345
TYR A 368
ILE A 376
PHE A 384
 None
 0.67A 3ihzA-4bf8A:
17.2		 3ihzA-4bf8A:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		6 TYR A 313
ASP A 324
PHE A 332
ILE A 342
TRP A 345
PHE A 384
 None
 0.97A 3ihzA-4bf8A:
17.2		 3ihzA-4bf8A:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 TYR A 313
ASP A 324
VAL A 341
ILE A 342
TRP A 345
TYR A 368
PHE A 384
 None
 0.75A 3ihzA-4bf8A:
17.2		 3ihzA-4bf8A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwi PHYTOCHROME-LIKE
PROTEIN CPH2

(Synechocystis
sp.) 		PF00360
(PHY)
PF01590
(GAF) 		5 TYR A 133
ASP A  79
ARG A 383
VAL A 139
ILE A 156
 CYC  A1422 (-4.1A)
CYC  A1422 (-4.0A)
None
None
CYC  A1422 ( 4.7A)
 1.40A 3ihzA-4bwiA:
undetectable		 3ihzA-4bwiA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		5 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.11A 3ihzA-4c0eA:
undetectable		 3ihzA-4c0eA:
13.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  52
TRP A  88
TYR A 111
ILE A 119
PHE A 127
 None
 0.57A 3ihzA-4dipA:
17.7		 3ihzA-4dipA:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		10 TYR A  33
ASP A  44
ARG A  49
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 FK5  A 201 ( 3.9A)
FK5  A 201 (-3.5A)
FK5  A 201 ( 3.7A)
FK5  A 201 (-4.1A)
FK5  A 201 ( 3.6A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.7A)
None
FK5  A 201 (-4.8A)
 0.42A 3ihzA-4dz3A:
20.2		 3ihzA-4dz3A:
40.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6f UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14730
(DUF4468) 		5 TYR A  36
ASP A 180
VAL A  41
ILE A 154
ILE A 104
 None
 1.46A 3ihzA-4e6fA:
undetectable		 3ihzA-4e6fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 PHE A 337
VAL A 346
ILE A 369
ILE A 375
PHE A 383
 None
 1.30A 3ihzA-4h09A:
undetectable		 3ihzA-4h09A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Vibrio cholerae) 		PF04095
(NAPRTase) 		5 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.42A 3ihzA-4hl7A:
undetectable		 3ihzA-4hl7A:
14.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  26
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TYR A  82
ILE A  91
PHE A  99
 None
 0.87A 3ihzA-4iqcA:
19.1		 3ihzA-4iqcA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  26
ASP A  37
ARG A  42
ILE A  56
TYR A  82
ILE A  91
PHE A  99
 None
 0.71A 3ihzA-4iqcA:
19.1		 3ihzA-4iqcA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.70A 3ihzA-4lawA:
20.8		 3ihzA-4lawA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.77A 3ihzA-4lawA:
20.8		 3ihzA-4lawA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C)
PF13499
(EF-hand_7) 		5 TYR A  33
TRP A  69
TYR A  92
ILE A 100
PHE A 108
 None
 0.51A 3ihzA-4mspA:
18.0		 3ihzA-4mspA:
24.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
 FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.5A)
None
FK5  A 201 (-4.9A)
 0.28A 3ihzA-4nnrA:
15.7		 3ihzA-4nnrA:
39.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Thermus
thermophilus) 		PF00254
(FKBP_C) 		5 TYR A  13
ASP A  23
ILE A  37
TYR A  63
PHE A 128
 None
 0.60A 3ihzA-4odmA:
11.1		 3ihzA-4odmA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Homo sapiens;
Thermus
thermophilus) 		PF00254
(FKBP_C) 		6 TYR A  13
ASP A  23
ILE A  37
TYR A  63
ILE A  72
PHE A  80
 FK5  A 201 ( 3.6A)
FK5  A 201 (-3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-4.4A)
None
FK5  A 201 ( 4.8A)
 0.47A 3ihzA-4odrA:
12.8		 3ihzA-4odrA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opw UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF10988
(DUF2807) 		5 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
 None
None
None
None
EDO  A 301 (-4.3A)
 1.14A 3ihzA-4opwA:
undetectable		 3ihzA-4opwA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Shewanella
benthica) 		PF00701
(DHDPS) 		5 ASP A 200
ARG A 174
PHE A 181
ILE A 131
ILE A   6
 None
 1.11A 3ihzA-4pfmA:
undetectable		 3ihzA-4pfmA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1)
PF10394
(Hat1_N) 		5 VAL A  24
ILE A  23
TYR A 226
ILE A 188
PHE A  63
 None
 1.18A 3ihzA-4pswA:
undetectable		 3ihzA-4pswA:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 PHE A  79
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 1.48A 3ihzA-4r0xA:
21.9		 3ihzA-4r0xA:
50.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
 0.83A 3ihzA-4r0xA:
21.9		 3ihzA-4r0xA:
50.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.86A 3ihzA-4r0xA:
21.9		 3ihzA-4r0xA:
50.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u LINKER L1

(Glossoscolex
paulistus) 		PF16915
(Eryth_link_C) 		5 ASP M 201
ARG M 176
VAL M 147
ILE M 132
PHE M 111
 None
 1.45A 3ihzA-4u8uM:
undetectable		 3ihzA-4u8uM:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		5 ASP A 944
PHE A 845
ILE A 840
TYR A 459
ILE A 883
 None
 1.14A 3ihzA-4zmhA:
undetectable		 3ihzA-4zmhA:
8.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		10 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.56A 3ihzA-5b8iC:
18.1		 3ihzA-5b8iC:
38.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 5 TYR A 531
ASP A 541
PHE A 503
VAL A 487
TRP A 515
 None
 1.35A 3ihzA-5gqfA:
undetectable		 3ihzA-5gqfA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsb RNA POLYMERASE

(Andes
orthohantavirus) 		no annotation 5 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.19A 3ihzA-5hsbA:
undetectable		 3ihzA-5hsbA:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 146
 None
 0.55A 3ihzA-5i7pA:
17.5		 3ihzA-5i7pA:
30.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 147
 None
 0.59A 3ihzA-5i7qA:
17.8		 3ihzA-5i7qA:
31.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		9 TYR A  30
ASP A  41
ARG A  46
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 102
 None
 1.32A 3ihzA-5i98A:
17.6		 3ihzA-5i98A:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		10 TYR A  30
ASP A  41
ARG A  46
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 106
PHE A 114
 None
 0.57A 3ihzA-5i98A:
17.6		 3ihzA-5i98A:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		5 TYR A  30
ASP A  41
PHE A  50
VAL A  59
ILE A 105
 None
 1.42A 3ihzA-5i98A:
17.6		 3ihzA-5i98A:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		10 TYR A  27
ASP A  38
ARG A  43
PHE A  47
VAL A  56
ILE A  57
TRP A  60
TYR A  83
ILE A  92
PHE A 100
 None
 0.56A 3ihzA-5j6eA:
19.3		 3ihzA-5j6eA:
42.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcv LMO2181 PROTEIN

(Listeria
monocytogenes) 		PF04203
(Sortase) 		5 ASP A 125
VAL A  75
ILE A  89
TYR A 161
ILE A 221
 None
 1.10A 3ihzA-5jcvA:
undetectable		 3ihzA-5jcvA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 ASP A 199
PHE A 226
VAL A 268
ILE A 523
PHE A 320
 None
 1.28A 3ihzA-5k5tA:
undetectable		 3ihzA-5k5tA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 ASP A 138
ARG A 141
VAL A 205
TYR A 177
ILE A 168
 None
 1.42A 3ihzA-5l1bA:
undetectable		 3ihzA-5l1bA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 5 TYR D 255
ASP D 199
ARG D 467
VAL D 261
ILE D 278
 LBV  D 601 (-4.2A)
LBV  D 601 (-4.3A)
None
None
None
 1.35A 3ihzA-5llyD:
undetectable		 3ihzA-5llyD:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msz THERMOBIA DOMESTICA
DOMESTICA AA15

(Thermobia
domestica) 		no annotation 5 ASP A  84
VAL A  72
ILE A 190
TYR A  75
ILE A  81
 None
 1.34A 3ihzA-5mszA:
undetectable		 3ihzA-5mszA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN

(Yersinia pestis) 		PF01042
(Ribonuc_L-PSP) 		5 TYR A 102
ARG A   3
ILE A 127
ILE A  33
PHE A 101
 None
 1.40A 3ihzA-5v4fA:
undetectable		 3ihzA-5v4fA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 10 TYR A  33
ASP A  44
ARG A  49
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-4.0A)
8ZV  A 201 (-3.3A)
8ZV  A 201 (-4.6A)
8ZV  A 201 ( 4.8A)
8ZV  A 201 (-4.6A)
 0.47A 3ihzA-5v8tA:
20.2		 3ihzA-5v8tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		5 TYR A 424
ASP A 110
VAL A 307
ILE A 310
PHE A 375
 None
 1.42A 3ihzA-5vf3A:
undetectable		 3ihzA-5vf3A:
14.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		7 PHE A 166
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
 TLA  A 301 ( 4.6A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
 1.03A 3ihzA-5xb0A:
16.0		 3ihzA-5xb0A:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		8 TYR A 147
ASP A 158
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
 0.67A 3ihzA-5xb0A:
16.0		 3ihzA-5xb0A:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhw PUTATIVE
6-DEOXY-D-MANNOHEPTO
SE PATHWAY PROTEIN

(Yersinia
pseudotuberculosis) 		no annotation 5 TYR A 207
VAL A 132
ILE A 165
TYR A 140
ILE A 213
 None
 1.40A 3ihzA-5xhwA:
undetectable		 3ihzA-5xhwA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 5 PHE A 330
VAL A 270
ILE A 285
TYR A 277
ILE A 378
 None
 1.22A 3ihzA-5y31A:
undetectable		 3ihzA-5y31A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii) 		no annotation 5 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
 None
 1.34A 3ihzA-5z0yA:
undetectable		 3ihzA-5z0yA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 10 TYR A  38
ASP A  49
ARG A  54
PHE A  58
VAL A  67
ILE A  68
TRP A  71
TYR A  94
ILE A 103
PHE A 111
 None
 0.59A 3ihzA-6b4pA:
21.4		 3ihzA-6b4pA:
42.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8

(Homo sapiens) 		no annotation 5 TYR A 344
ASP A  84
ARG A 355
VAL A 402
ILE A 406
 None
 1.21A 3ihzA-6bszA:
undetectable		 3ihzA-6bszA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d12 LA-RELATED PROTEIN 7

(Homo sapiens) 		no annotation 5 ARG A 472
VAL A 457
ILE A 456
TYR A 532
ILE A 536
 G  C 333 ( 3.7A)
None
None
G  C 331 ( 4.7A)
G  C 331 ( 4.0A)
 1.18A 3ihzA-6d12A:
undetectable		 3ihzA-6d12A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3

(Homo sapiens) 		no annotation 5 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.36A 3ihzA-6ez4A:
undetectable		 3ihzA-6ez4A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 ASP A 136
GLY A 228
SER A 197
ILE A 229
 None
 0.67A 3ihzB-1do5A:
undetectable		 3ihzB-1do5A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elp GAMMA-D CRYSTALLIN

(Bos taurus) 		PF00030
(Crystall) 		4 TYR A   6
PHE A  11
GLY A   1
SER A  19
 None
 0.85A 3ihzB-1elpA:
undetectable		 3ihzB-1elpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 TYR A 195
GLY A 147
SER A 150
ILE A 149
 None
 0.79A 3ihzB-1eovA:
undetectable		 3ihzB-1eovA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 PHE A 153
TRP A 162
TYR A 185
GLY A 191
ILE A 194
 None
 1.31A 3ihzB-1fd9A:
17.6		 3ihzB-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 PHE A 153
TRP A 162
TYR A 185
GLY A 192
ILE A 194
 None
 1.40A 3ihzB-1fd9A:
17.6		 3ihzB-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 TYR A 131
ASP A 142
TRP A 162
TYR A 185
GLY A 191
ILE A 194
 None
 0.76A 3ihzB-1fd9A:
17.6		 3ihzB-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 131
TRP A 162
TYR A 185
GLY A 192
ILE A 194
 None
 0.92A 3ihzB-1fd9A:
17.6		 3ihzB-1fd9A:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		6 TYR A  26
ASP A  37
PHE A  46
TRP A  59
TYR A  82
ILE A  91
 None
 0.55A 3ihzB-1fkkA:
19.7		 3ihzB-1fkkA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		5 PHE A 114
TRP A 123
TYR A 146
GLY A 152
ILE A 155
 None
 1.35A 3ihzB-1jvwA:
16.2		 3ihzB-1jvwA:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		5 PHE A 114
TRP A 123
TYR A 146
GLY A 153
ILE A 155
 None
 1.08A 3ihzB-1jvwA:
16.2		 3ihzB-1jvwA:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		6 TYR A  92
ASP A 103
TRP A 123
TYR A 146
GLY A 153
ILE A 155
 None
 0.47A 3ihzB-1jvwA:
16.2		 3ihzB-1jvwA:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		4 ASP A 245
GLY A 240
SER A 242
ILE A 284
 None
 0.83A 3ihzB-1ka0A:
undetectable		 3ihzB-1ka0A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		4 TYR A  57
PHE A  77
TRP A  90
ILE A 122
 None
 0.87A 3ihzB-1kt1A:
17.6		 3ihzB-1kt1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4j A6 GENE PRODUCT

(Mus musculus) 		PF00241
(Cofilin_ADF) 		4 TYR A 134
ASP A 119
GLY A 115
ILE A 117
 None
 0.88A 3ihzB-1m4jA:
undetectable		 3ihzB-1m4jA:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
TRP A  90
TYR A 113
ILE A 122
 None
 0.48A 3ihzB-1n1aA:
21.1		 3ihzB-1n1aA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A 135
TRP A 175
TYR A 198
ILE A 208
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.4A)
RAP  A 225 (-4.6A)
RAP  A 225 ( 4.9A)
 0.49A 3ihzB-1pbkA:
18.2		 3ihzB-1pbkA:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 146
ASP A 157
TRP A 177
TYR A 200
ILE A 208
 None
 0.57A 3ihzB-1q6hA:
17.1		 3ihzB-1q6hA:
26.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		6 TYR A  40
ASP A  51
PHE A  60
TRP A  73
TYR A  96
ILE A 105
 None
 0.34A 3ihzB-1r9hA:
22.9		 3ihzB-1r9hA:
47.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1)
PF13177
(DNA_pol3_delta2) 		4 TYR E 287
GLY A 624
SER A 622
ILE A 621
 None
 0.90A 3ihzB-1sxjE:
undetectable		 3ihzB-1sxjE:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twl INORGANIC
PYROPHOSPHATASE

(Pyrococcus
furiosus) 		PF00719
(Pyrophosphatase) 		4 ASP A  43
TYR A  52
GLY A  57
ILE A  23
 None
 0.73A 3ihzB-1twlA:
undetectable		 3ihzB-1twlA:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		5 TYR A  37
ASP A  48
TRP A  70
TYR A  99
ILE A 113
 None
 0.34A 3ihzB-1u79A:
19.2		 3ihzB-1u79A:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		4 TYR A  26
ASP A  37
GLY A  89
ILE A  91
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
None
None
 0.88A 3ihzB-1yatA:
21.0		 3ihzB-1yatA:
39.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		5 TYR A  26
PHE A  46
TRP A  59
TYR A  82
ILE A  91
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.6A)
FK5  A 108 ( 4.7A)
None
 0.38A 3ihzB-1yatA:
21.0		 3ihzB-1yatA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2do8 UPF0301 PROTEIN
HD_1794

([Haemophilus]
ducreyi) 		PF02622
(DUF179) 		4 PHE A  21
GLY A 175
SER A 177
ILE A 176
 None
 0.73A 3ihzB-2do8A:
undetectable		 3ihzB-2do8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 ASP A 386
TYR A 316
GLY A 367
SER A 364
 None
 0.76A 3ihzB-2gjxA:
undetectable		 3ihzB-2gjxA:
14.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		4 TYR A  27
PHE A  47
TRP A  60
ILE A  92
 None
 0.79A 3ihzB-2lpvA:
16.6		 3ihzB-2lpvA:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr4 CONSERVED
HYPOTHETICAL PROTEIN

(Methanosarcina
mazei) 		PF04289
(DUF447) 		4 TRP A 118
GLY A  47
SER A  30
ILE A  32
 None
FMN  A 401 (-3.6A)
None
None
 0.89A 3ihzB-2nr4A:
undetectable		 3ihzB-2nr4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oc6 YDHG PROTEIN

(Bacillus
subtilis) 		PF08818
(DUF1801) 		4 ASP A  76
TYR A  85
GLY A  82
ILE A  78
 None
 0.86A 3ihzB-2oc6A:
undetectable		 3ihzB-2oc6A:
25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
ASP A  67
PHE A  76
TRP A  89
ILE A 121
 PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.7A)
None
 0.86A 3ihzB-2pbcA:
15.4		 3ihzB-2pbcA:
42.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
ASP A  67
TRP A  89
TYR A 112
ILE A 121
 PEG  A 201 (-4.4A)
None
PEG  A 201 (-3.7A)
None
None
 0.70A 3ihzB-2pbcA:
15.4		 3ihzB-2pbcA:
42.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 PHE A  77
GLY A 128
SER A 164
ILE A 163
 None
 0.77A 3ihzB-2pt6A:
undetectable		 3ihzB-2pt6A:
16.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		4 TYR A  55
TRP A  86
TYR A 109
GLY A 116
 RAP  A 138 (-2.6A)
RAP  A 138 (-2.3A)
RAP  A 138 (-3.8A)
None
 0.68A 3ihzB-2vcdA:
14.9		 3ihzB-2vcdA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		5 TYR A  44
PHE A  65
TRP A  78
TYR A 101
ILE A 110
 FK5  A 501 (-4.1A)
FK5  A 501 (-4.1A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.7A)
None
 0.40A 3ihzB-2vn1A:
24.1		 3ihzB-2vn1A:
80.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		5 TYR A  44
TRP A  78
TYR A 101
GLY A 107
ILE A 110
 FK5  A 501 (-4.1A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.7A)
None
None
 0.80A 3ihzB-2vn1A:
24.1		 3ihzB-2vn1A:
80.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 278
ASP A 218
GLY A 243
ILE A 247
 None
 0.89A 3ihzB-2x50A:
undetectable		 3ihzB-2x50A:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		6 TYR A  33
ASP A  44
PHE A  53
TRP A  66
GLY A  96
ILE A  98
 None
 0.65A 3ihzB-2y78A:
19.7		 3ihzB-2y78A:
38.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		6 TYR A  33
ASP A  44
PHE A  53
TRP A  66
TYR A  89
GLY A  96
 None
 0.59A 3ihzB-2y78A:
19.7		 3ihzB-2y78A:
38.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		4 PHE A 185
GLY A  54
SER A  50
ILE A  53
 None
 0.89A 3ihzB-2ywdA:
undetectable		 3ihzB-2ywdA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ASP A 278
GLY A 307
SER A 309
ILE A 276
 None
None
FAD  A 622 ( 4.4A)
None
 0.69A 3ihzB-3cp8A:
undetectable		 3ihzB-3cp8A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 305
ASP A 126
PHE A  18
GLY A 255
 None
 0.78A 3ihzB-3fhlA:
undetectable		 3ihzB-3fhlA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		4 TYR A  74
ASP A 473
GLY A 452
SER A 408
 None
 0.87A 3ihzB-3foaA:
undetectable		 3ihzB-3foaA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A 457
GLY A 180
SER A 322
ILE A 321
 HBX  A 530 (-4.3A)
None
None
None
 0.84A 3ihzB-3gdnA:
undetectable		 3ihzB-3gdnA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir3 3-HYDROXYACYL-THIOES
TER DEHYDRATASE 2

(Homo sapiens) 		PF01575
(MaoC_dehydratas) 		4 PHE A  48
GLY A 156
SER A 113
ILE A 112
 None
 0.89A 3ihzB-3ir3A:
undetectable		 3ihzB-3ir3A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 TYR U  74
ASP U 473
GLY U 452
SER U 408
 None
 0.87A 3ihzB-3j2nU:
undetectable		 3ihzB-3j2nU:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lat BIFUNCTIONAL
AUTOLYSIN

(Staphylococcus
epidermidis) 		PF01510
(Amidase_2) 		4 PHE A  84
GLY A 173
SER A 169
ILE A 168
 None
 0.92A 3ihzB-3latA:
undetectable		 3ihzB-3latA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
TRP A  90
TYR A 113
ILE A 122
 None
 0.59A 3ihzB-3o5dA:
20.9		 3ihzB-3o5dA:
29.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
PHE A  77
TRP A  90
ILE A 122
 None
 0.59A 3ihzB-3o5eA:
21.3		 3ihzB-3o5eA:
44.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
PHE A  77
TYR A 113
ILE A 122
 None
 0.41A 3ihzB-3o5eA:
21.3		 3ihzB-3o5eA:
44.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		8 TYR A  43
ASP A  55
PHE A  64
TRP A  77
TYR A 100
GLY A 106
SER A 108
ILE A 109
 None
 0.53A 3ihzB-3pa7A:
25.5		 3ihzB-3pa7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q46 TT-IPPASE

(Thermococcus
thioreducens) 		PF00719
(Pyrophosphatase) 		4 ASP A  43
TYR A  52
GLY A  57
ILE A  23
 EPE  A 309 ( 4.3A)
None
None
None
 0.78A 3ihzB-3q46A:
undetectable		 3ihzB-3q46A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6y ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1) 		4 ASP A  93
GLY A 100
SER A 102
ILE A 103
 ASP  A  93 ( 0.5A)
GLY  A 100 ( 0.0A)
SER  A 102 ( 0.0A)
ILE  A 103 ( 0.6A)
 0.69A 3ihzB-3r6yA:
undetectable		 3ihzB-3r6yA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		4 PHE A 178
TRP A 166
GLY A  57
ILE A  59
 None
 0.81A 3ihzB-3rrwA:
undetectable		 3ihzB-3rrwA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 TYR A 809
GLY A1013
SER A1060
ILE A1014
 None
 0.79A 3ihzB-3s5kA:
undetectable		 3ihzB-3s5kA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		4 ASP A  44
GLY A 138
SER A 140
ILE A 139
 None
 0.77A 3ihzB-3vvlA:
undetectable		 3ihzB-3vvlA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		4 TYR A  51
GLY A  16
SER A  14
ILE A  15
 None
 0.92A 3ihzB-3wj9A:
undetectable		 3ihzB-3wj9A:
16.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		4 TYR A 313
ASP A 324
PHE A 332
TRP A 345
 None
 0.63A 3ihzB-4bf8A:
17.4		 3ihzB-4bf8A:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TRP A  88
TYR A 111
GLY A 117
ILE A 119
 None
 0.88A 3ihzB-4dipA:
18.0		 3ihzB-4dipA:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A  52
TRP A  88
TYR A 111
ILE A 119
 None
 0.50A 3ihzB-4dipA:
18.0		 3ihzB-4dipA:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1

(Danio rerio) 		PF00079
(Serpin) 		4 TYR A 374
GLY A 138
SER A 141
ILE A 140
 None
 0.89A 3ihzB-4dteA:
undetectable		 3ihzB-4dteA:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		6 TYR A  33
PHE A  53
TRP A  66
TYR A  89
GLY A  95
ILE A  98
 FK5  A 201 ( 3.9A)
FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.7A)
None
None
 0.61A 3ihzB-4dz3A:
20.4		 3ihzB-4dz3A:
40.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9k HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF14717
(DUF4465) 		4 ASP A 145
TYR A  27
GLY A  72
ILE A  73
 None
 0.78A 3ihzB-4e9kA:
undetectable		 3ihzB-4e9kA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecp INORGANIC
PYROPHOSPHATASE

(Mycobacterium
leprae) 		PF00719
(Pyrophosphatase) 		4 ASP A  29
TYR A  38
GLY A  43
ILE A   9
 None
 0.77A 3ihzB-4ecpA:
undetectable		 3ihzB-4ecpA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 TYR A  44
PHE A  43
GLY A 162
ILE A  75
 None
 0.84A 3ihzB-4ewtA:
undetectable		 3ihzB-4ewtA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		4 ASP A 155
GLY A 180
SER A 182
ILE A 157
 None
 0.85A 3ihzB-4g09A:
undetectable		 3ihzB-4g09A:
12.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A  26
ASP A  37
PHE A  46
TYR A  82
 None
 0.51A 3ihzB-4iqcA:
19.6		 3ihzB-4iqcA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A  26
PHE A  46
TYR A  82
ILE A  91
 None
 0.66A 3ihzB-4iqcA:
19.6		 3ihzB-4iqcA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgf GAMMA-CRYSTALLIN D

(Homo sapiens) 		PF00030
(Crystall) 		4 TYR A   6
PHE A  11
GLY A   1
SER A  19
 None
 0.64A 3ihzB-4jgfA:
undetectable		 3ihzB-4jgfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhs BETA-2-GLYCOPROTEIN
1

(Homo sapiens) 		PF00084
(Sushi)
PF09014
(Sushi_2) 		4 TYR A 275
ASP A 294
GLY A 318
ILE A 320
 None
 0.92A 3ihzB-4jhsA:
undetectable		 3ihzB-4jhsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
TRP A  90
TYR A 113
ILE A 122
 None
None
None
DMS  A 304 ( 4.0A)
None
None
 0.46A 3ihzB-4lawA:
21.1		 3ihzB-4lawA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		4 ASP A  15
GLY A  51
SER A  59
ILE A  58
 None
 0.76A 3ihzB-4ldnA:
undetectable		 3ihzB-4ldnA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		4 ASP A 183
GLY A 143
SER A 169
ILE A 168
 None
 0.75A 3ihzB-4m0dA:
undetectable		 3ihzB-4m0dA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C)
PF13499
(EF-hand_7) 		5 TYR A  33
TRP A  69
TYR A  92
GLY A  98
ILE A 100
 None
 0.83A 3ihzB-4mspA:
17.9		 3ihzB-4mspA:
24.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
PHE A  76
TRP A  89
TYR A 112
ILE A 121
 FK5  A 201 (-4.1A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.5A)
None
 0.40A 3ihzB-4nnrA:
15.5		 3ihzB-4nnrA:
39.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ASP A 477
TYR A 521
GLY A 483
ILE A 479
 None
 0.91A 3ihzB-4pvgA:
undetectable		 3ihzB-4pvgA:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
TRP A  90
TYR A 113
ILE A 122
 None
 0.58A 3ihzB-4r0xA:
22.5		 3ihzB-4r0xA:
50.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 PHE A  77
GLY A 128
SER A 164
ILE A 163
 None
 0.78A 3ihzB-4uoeA:
undetectable		 3ihzB-4uoeA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		4 TYR A  48
ASP A 307
GLY A  87
SER A  83
 None
 0.87A 3ihzB-4yhsA:
undetectable		 3ihzB-4yhsA:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		4 TYR C  36
ASP C  56
PHE C  64
GLY C 107
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
EDO  C 204 (-3.6A)
 0.59A 3ihzB-5b8iC:
18.3		 3ihzB-5b8iC:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		5 TYR C  36
PHE C  64
TRP C  77
TYR C 100
ILE C 109
 FK5  C 201 (-4.1A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
 0.48A 3ihzB-5b8iC:
18.3		 3ihzB-5b8iC:
38.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		4 ASP A1376
TYR A1245
SER A1898
ILE A1897
 None
None
OGA  A2001 (-2.7A)
None
 0.89A 3ihzB-5deuA:
undetectable		 3ihzB-5deuA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 ASP A 477
TYR A 521
GLY A 483
ILE A 479
 None
 0.89A 3ihzB-5i6vA:
undetectable		 3ihzB-5i6vA:
14.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  26
ASP A  37
PHE A  46
TRP A  59
TYR A  82
 None
 0.41A 3ihzB-5i7pA:
18.1		 3ihzB-5i7pA:
30.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  26
ASP A  37
PHE A  46
TRP A  59
TYR A  82
 None
 0.55A 3ihzB-5i7qA:
18.3		 3ihzB-5i7qA:
31.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		4 TYR A  30
ASP A  41
PHE A  50
ILE A 105
 None
 0.88A 3ihzB-5i98A:
18.0		 3ihzB-5i98A:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		6 TYR A  30
ASP A  41
PHE A  50
TRP A  63
TYR A  97
ILE A 106
 None
 0.51A 3ihzB-5i98A:
18.0		 3ihzB-5i98A:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		6 TYR A  27
ASP A  38
PHE A  47
TRP A  60
TYR A  83
ILE A  92
 None
 0.45A 3ihzB-5j6eA:
19.8		 3ihzB-5j6eA:
42.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd7 KINESIN-LIKE PROTEIN
KIF20A

(Mus musculus) 		PF00225
(Kinesin) 		4 TYR C 158
PHE C 499
GLY C 427
ILE C 429
 None
 0.87A 3ihzB-5nd7C:
undetectable		 3ihzB-5nd7C:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 4 TYR A 217
PHE A 215
TYR A 179
ILE A 204
 None
 0.71A 3ihzB-5o8rA:
undetectable		 3ihzB-5o8rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 5 TYR A  33
ASP A  44
PHE A  53
GLY A  96
ILE A  98
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.9A)
None
8ZV  A 201 ( 4.8A)
 0.84A 3ihzB-5v8tA:
20.5		 3ihzB-5v8tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 6 TYR A  33
PHE A  53
TRP A  66
TYR A  89
GLY A  96
ILE A  98
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.3A)
8ZV  A 201 (-4.6A)
None
8ZV  A 201 ( 4.8A)
 0.69A 3ihzB-5v8tA:
20.5		 3ihzB-5v8tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TYR A  98
GLY A 100
SER A 102
ILE A 101
 None
 0.83A 3ihzB-5vniA:
undetectable		 3ihzB-5vniA:
10.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		5 ASP A 158
PHE A 166
TRP A 175
TYR A 198
ILE A 207
 TLA  A 301 (-3.7A)
TLA  A 301 ( 4.6A)
TLA  A 301 (-3.4A)
None
None
 1.23A 3ihzB-5xb0A:
16.4		 3ihzB-5xb0A:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		5 TYR A 147
ASP A 158
TRP A 175
TYR A 198
ILE A 207
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
None
None
 0.64A 3ihzB-5xb0A:
16.4		 3ihzB-5xb0A:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6atk SPIKE GLYCOPROTEIN

(Human
coronavirus
229E) 		no annotation 4 ASP E 342
GLY E 424
SER E 344
ILE E 425
 None
 0.87A 3ihzB-6atkE:
undetectable		 3ihzB-6atkE:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 4 TYR A  38
ASP A  49
PHE A  58
GLY A 101
 None
 0.64A 3ihzB-6b4pA:
22.0		 3ihzB-6b4pA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 5 TYR A  38
ASP A  49
PHE A  58
TRP A  71
ILE A 103
 None
 0.75A 3ihzB-6b4pA:
22.0		 3ihzB-6b4pA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 5 TYR A  38
PHE A  58
TRP A  71
TYR A  94
ILE A 103
 None
 0.61A 3ihzB-6b4pA:
22.0		 3ihzB-6b4pA:
42.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 4 ASP A 425
TYR A 273
GLY A  85
ILE A 192
 FMT  A 601 (-3.7A)
None
None
None
 0.73A 3ihzB-6begA:
undetectable		 3ihzB-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 8

(Ficedula
albicollis) 		no annotation 4 TYR A 497
PHE A 531
SER A 577
ILE A 580
 None
 0.85A 3ihzB-6bpqA:
undetectable		 3ihzB-6bpqA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 4 ASP A 226
GLY A 218
SER A 233
ILE A 232
 None
 0.89A 3ihzB-6c54A:
undetectable		 3ihzB-6c54A:
21.93