SIMILAR PATTERNS OF AMINO ACIDS FOR 3IEO_A_AMJA300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Mycobacterium
tuberculosis) 		PF01625
(PMSR) 		4 ILE A  75
GLN A  74
VAL A 157
PHE A  71
 None
 1.46A 3ieoA-1nwaA:
0.0		 3ieoA-1nwaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqf PROTEIN (COMPLEMENT
C3DG)

(Rattus
norvegicus) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ILE A1130
GLN A1127
VAL A1124
PHE A1133
 None
 1.45A 3ieoA-1qqfA:
undetectable		 3ieoA-1qqfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uai POLYGULURONATE LYASE

(Corynebacterium
sp.) 		PF08787
(Alginate_lyase2) 		4 ILE A 137
GLN A 178
VAL A 148
PHE A 128
 None
 0.96A 3ieoA-1uaiA:
0.0		 3ieoA-1uaiA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2daq WHSC1L1 PROTEIN,
ISOFORM LONG

(Homo sapiens) 		PF00855
(PWWP) 		4 ILE A  29
GLN A  13
VAL A  15
PHE A  49
 None
 1.10A 3ieoA-2daqA:
0.0		 3ieoA-2daqA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqj METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2

(Mus musculus) 		no annotation 4 ILE A  34
GLN A  18
VAL A  20
PHE A  14
 None
 1.24A 3ieoA-2eqjA:
0.0		 3ieoA-2eqjA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 ILE A 701
GLN A 696
VAL A 719
PHE A 727
 None
 1.37A 3ieoA-2fuqA:
0.0		 3ieoA-2fuqA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inf UROPORPHYRINOGEN
DECARBOXYLASE

(Bacillus
subtilis) 		PF01208
(URO-D) 		4 ILE A 317
GLN A 284
VAL A 262
PHE A  11
 None
 1.19A 3ieoA-2infA:
0.0		 3ieoA-2infA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1

(Rhodobacter
capsulatus) 		PF00072
(Response_reg) 		4 ILE A   8
GLN A  50
VAL A  51
PHE A  29
 None
 1.47A 3ieoA-2jk1A:
0.0		 3ieoA-2jk1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jr5 UPF0350 PROTEIN
VC_2471

(Vibrio cholerae) 		PF03937
(Sdh5) 		4 ILE A  10
GLN A   6
VAL A  45
PHE A  29
 None
 1.18A 3ieoA-2jr5A:
undetectable		 3ieoA-2jr5A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4m UNCHARACTERIZED
PROTEIN

(Homo sapiens) 		PF02295
(z-alpha) 		4 ILE A 128
GLN A 123
VAL A 127
PHE A 116
 None
 1.50A 3ieoA-2l4mA:
undetectable		 3ieoA-2l4mA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD

(Aquifex
aeolicus) 		PF00005
(ABC_tran) 		4 ILE A 151
GLN A 147
VAL A  87
PHE A 183
 None
 1.10A 3ieoA-2pclA:
0.0		 3ieoA-2pclA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 ILE A 334
GLN A 302
VAL A 279
PHE A  19
 None
 1.13A 3ieoA-2q6zA:
undetectable		 3ieoA-2q6zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eua PUTATIVE
FRUCTOSE-AMINOACID-6
-PHOSPHATE DEGLYCASE

(Bacillus
subtilis) 		PF01380
(SIS) 		4 ILE A 161
GLN A 142
VAL A   8
PHE A 157
 None
 1.15A 3ieoA-3euaA:
undetectable		 3ieoA-3euaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		4 ILE A 300
GLN A 346
VAL A 348
PHE A 342
 None
 1.50A 3ieoA-3floA:
undetectable		 3ieoA-3floA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnv CDGSH IRON SULFUR
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF09360
(zf-CDGSH) 		4 ILE A  75
GLN A  76
VAL A  82
PHE A 107
 None
 1.27A 3ieoA-3fnvA:
undetectable		 3ieoA-3fnvA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus) 		PF01766
(Birna_VP2) 		4 ILE A 296
GLN A 294
VAL A 274
PHE A 262
 None
 1.35A 3ieoA-3ideA:
undetectable		 3ieoA-3ideA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l43 DYNAMIN-3

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 ILE A 135
GLN A  33
VAL A  70
PHE A 163
 None
 1.26A 3ieoA-3l43A:
undetectable		 3ieoA-3l43A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ILE A1095
GLN A1098
VAL A 912
PHE A1091
 None
 1.48A 3ieoA-3qciA:
undetectable		 3ieoA-3qciA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		4 ILE A 223
GLN A 227
VAL A 200
PHE A 216
 None
 1.39A 3ieoA-3qphA:
undetectable		 3ieoA-3qphA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 ILE A 364
GLN A 292
VAL A 356
PHE A 290
 None
 1.30A 3ieoA-3s29A:
undetectable		 3ieoA-3s29A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9x ASCH DOMAIN

(Vibrio cholerae) 		PF04266
(ASCH) 		4 ILE A  88
GLN A  75
VAL A  77
PHE A 149
 None
 1.18A 3ieoA-3s9xA:
undetectable		 3ieoA-3s9xA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		4 ILE A 474
GLN A  98
VAL A 481
PHE A 100
 None
 1.38A 3ieoA-3vssA:
undetectable		 3ieoA-3vssA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt2 PROTEIN
DISULFIDE-ISOMERASE

(Humicola
insolens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 ILE A 257
GLN A 253
VAL A 312
PHE A 259
 None
 1.27A 3ieoA-3wt2A:
undetectable		 3ieoA-3wt2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btf MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 259
GLN A 261
VAL A 229
PHE A 268
 None
 1.40A 3ieoA-4btfA:
undetectable		 3ieoA-4btfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4r PHOSPHATE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF01515
(PTA_PTB) 		4 ILE A 321
GLN A 325
VAL A 295
PHE A 154
 None
 1.37A 3ieoA-4e4rA:
undetectable		 3ieoA-4e4rA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		4 ILE A 471
GLN A 473
VAL A 520
PHE A 511
 None
 1.45A 3ieoA-4fwwA:
undetectable		 3ieoA-4fwwA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE

(Homo sapiens) 		PF05301
(Acetyltransf_16) 		4 ILE A 185
GLN A 179
VAL A 106
PHE A 190
 None
 1.44A 3ieoA-4gs4A:
undetectable		 3ieoA-4gs4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ILE A 500
GLN A 482
VAL A 488
PHE A 520
 None
 1.12A 3ieoA-4o9xA:
undetectable		 3ieoA-4o9xA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ooa CDGSH IRON-SULFUR
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF09360
(zf-CDGSH) 		4 ILE A  75
GLN A  76
VAL A  82
PHE A 107
 None
 1.29A 3ieoA-4ooaA:
undetectable		 3ieoA-4ooaA:
13.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 ILE A  91
GLN A  92
VAL A 121
PHE A 131
 None
 0.23A 3ieoA-4qk3A:
43.8		 3ieoA-4qk3A:
95.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		4 ILE A 283
GLN A 284
VAL A 280
PHE A 295
 None
 0.92A 3ieoA-5afuA:
undetectable		 3ieoA-5afuA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE

(Caulobacter
vibrioides) 		PF00561
(Abhydrolase_1) 		4 ILE A 288
GLN A 281
VAL A 280
PHE A 120
 None
 1.46A 3ieoA-5esrA:
undetectable		 3ieoA-5esrA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		4 ILE A 419
GLN A 417
VAL A 320
PHE A 330
 None
 1.13A 3ieoA-5fhzA:
undetectable		 3ieoA-5fhzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfn CEPHALOSPORIN-C
DEACETYLASE

(Thermotoga
maritima) 		PF05448
(AXE1) 		4 ILE A 111
GLN A 176
VAL A  75
PHE A 174
 None
 1.37A 3ieoA-5hfnA:
undetectable		 3ieoA-5hfnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omm CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 ILE A 338
GLN A 340
VAL A 386
PHE A 378
 None
 1.19A 3ieoA-5ommA:
undetectable		 3ieoA-5ommA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy1 STRA6

(Danio rerio) 		PF14752
(RBP_receptor) 		4 ILE A 520
GLN A 417
VAL A 521
PHE A 421
 CLR  A 701 (-4.9A)
None
None
None
 1.47A 3ieoA-5sy1A:
undetectable		 3ieoA-5sy1A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqd DUMPY: SHORTER THAN
WILD-TYPE

(Caenorhabditis
elegans) 		no annotation 4 ILE A1529
GLN A1594
VAL A1559
PHE A1531
 None
 1.38A 3ieoA-5uqdA:
undetectable		 3ieoA-5uqdA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uro PREDICTED PROTEIN

(Trichoderma
reesei) 		PF00561
(Abhydrolase_1) 		4 ILE A 327
GLN A  56
VAL A 323
PHE A 137
 None
 1.19A 3ieoA-5uroA:
undetectable		 3ieoA-5uroA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE B 261
GLN B 263
VAL B 206
PHE B 284
 None
 1.05A 3ieoA-5vljB:
undetectable		 3ieoA-5vljB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrv PROTEIN REGULATED BY
ACID PH

(Agrobacterium
fabrum) 		PF09924
(DUF2156) 		4 ILE A 548
GLN A 552
VAL A 549
PHE A 576
 None
 1.06A 3ieoA-5vrvA:
undetectable		 3ieoA-5vrvA:
24.19