SIMILAR PATTERNS OF AMINO ACIDS FOR 3ID5_B_SAMB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8z TUBBY PROTEIN

(Mus musculus) 		PF01167
(Tub) 		5 TYR A 327
GLY A 329
ALA A 492
ASP A 344
GLN A 489
 None
 1.21A 3id5B-1c8zA:
0.0		 3id5B-1c8zA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 5 GLY P  30
ASP P  80
ALA P  79
ASP P  49
ILE P  29
 None
 1.33A 3id5B-1cf2P:
5.0		 3id5B-1cf2P:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 TYR A 406
GLY A 519
THR A  14
ASP A 518
ILE A 517
 None
 1.31A 3id5B-1dedA:
0.0		 3id5B-1dedA:
15.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		7 LYS A  58
GLY A  82
THR A  88
GLU A 105
ASP A 130
ALA A 131
ASP A 150
 None
 0.94A 3id5B-1fbnA:
30.3		 3id5B-1fbnA:
49.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		6 LYS A  58
THR A  88
GLU A 105
ALA A 131
ASP A 150
GLN A 153
 None
 1.02A 3id5B-1fbnA:
30.3		 3id5B-1fbnA:
49.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		7 LYS A  58
TYR A  80
GLY A  82
THR A  88
ASP A 130
ALA A 131
ASP A 150
 None
 0.96A 3id5B-1fbnA:
30.3		 3id5B-1fbnA:
49.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		6 LYS A  58
TYR A  80
THR A  88
ALA A 131
ASP A 150
GLN A 153
 None
 1.07A 3id5B-1fbnA:
30.3		 3id5B-1fbnA:
49.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 TYR A 406
GLY A 519
THR A  14
ASP A 518
ILE A 517
 None
 1.33A 3id5B-1kclA:
0.0		 3id5B-1kclA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mab PROTEIN (F1-ATPASE
BETA CHAIN)

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 TYR B 219
GLY B 185
ALA B 233
ILE B 255
GLN B 308
 None
 1.11A 3id5B-1mabB:
undetectable		 3id5B-1mabB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mab PROTEIN (F1-ATPASE
BETA CHAIN)

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 TYR B 219
GLY B 185
ASP B 256
ILE B 255
GLN B 308
 None
None
PO4  B 601 ( 4.4A)
None
None
 1.32A 3id5B-1mabB:
undetectable		 3id5B-1mabB:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		8 LYS A  42
THR A  70
GLU A  88
ASP A 113
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 SAM  A 301 (-3.0A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 1.23A 3id5B-1nt2A:
26.6		 3id5B-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		9 LYS A  42
TYR A  63
GLY A  65
GLU A  88
ASP A 113
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 SAM  A 301 (-3.0A)
None
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 0.81A 3id5B-1nt2A:
26.6		 3id5B-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		9 TYR A  63
GLY A  65
THR A  71
GLU A  88
ASP A 113
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 None
SAM  A 301 ( 3.8A)
SAM  A 301 (-4.1A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 0.80A 3id5B-1nt2A:
26.6		 3id5B-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		6 TYR A 131
THR A  71
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 None
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 1.48A 3id5B-1nt2A:
26.6		 3id5B-1nt2A:
41.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmg RHAMNOGALACTURONASE
A

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		5 GLY A 178
THR A 201
ASP A 147
ALA A 148
ASP A 177
 None
 1.36A 3id5B-1rmgA:
undetectable		 3id5B-1rmgA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 GLY E 187
PHE E 257
ASP E 252
ILE E 251
GLN E 304
 None
 1.31A 3id5B-1skyE:
undetectable		 3id5B-1skyE:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE

(Sulfolobus
solfataricus) 		PF00701
(DHDPS) 		5 TYR A 128
GLY A  95
THR A 152
PHE A  91
ILE A  69
 None
 1.36A 3id5B-1w3iA:
undetectable		 3id5B-1w3iA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		5 GLY A  98
GLU A 122
ASP A 150
ASP A 166
ILE A 167
 None
 0.56A 3id5B-1yb2A:
15.1		 3id5B-1yb2A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq1 GLUTATHIONE
S-TRANSFERASE

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 GLY A  80
PHE A 149
ASP A 159
ALA A 158
ILE A 151
 None
 1.29A 3id5B-1yq1A:
undetectable		 3id5B-1yq1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		no annotation 5 TYR A 301
GLY A 177
THR A 303
GLU A 172
ASP A 176
 None
 1.23A 3id5B-2be1A:
undetectable		 3id5B-2be1A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Bacillus
subtilis) 		PF02390
(Methyltransf_4) 		5 GLY A  46
THR A 191
GLU A  69
ASP A  96
ALA A  97
 K  A 250 (-3.9A)
None
None
None
None
 1.08A 3id5B-2fcaA:
11.7		 3id5B-2fcaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpy O-METHYLTRANSFERASE

(Bacillus
halodurans) 		PF01596
(Methyltransf_3) 		5 GLY A  62
GLU A  85
ASP A 113
ALA A 114
GLN A 138
 None
None
ZN  A 306 ( 4.7A)
None
None
 0.99A 3id5B-2gpyA:
14.2		 3id5B-2gpyA:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		8 TYR A 166
GLY A 168
THR A 174
GLU A 192
ASP A 217
ALA A 218
ASP A 237
GLN A 240
 None
MTA  A4001 (-3.3A)
None
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
MTA  A4001 (-4.0A)
 0.70A 3id5B-2ipxA:
31.8		 3id5B-2ipxA:
44.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jv8 UNCHARACTERIZED
PROTEIN NE1242

(Nitrosomonas
europaea) 		no annotation 5 GLU A   6
PHE A   8
ALA A  56
ASP A  14
ILE A  23
 None
 1.35A 3id5B-2jv8A:
undetectable		 3id5B-2jv8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		5 THR A  33
GLU A  99
ALA A 133
ASP A  93
ILE A  92
 None
 1.30A 3id5B-2nq9A:
undetectable		 3id5B-2nq9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrh TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE,
BAF FAMILY

(Campylobacter
jejuni) 		PF03309
(Pan_kinase) 		5 GLY A 107
THR A  66
ALA A 163
ASP A  97
ILE A  96
 None
 1.29A 3id5B-2nrhA:
undetectable		 3id5B-2nrhA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
megaterium;
Bacillus
megaterium) 		PF13377
(Peripla_BP_3)
PF00381
(PTS-HPr) 		6 GLY G 298
THR L  20
ALA G 145
ASP G 296
ILE G 297
GLN G 292
 None
 1.46A 3id5B-2nzuG:
undetectable		 3id5B-2nzuG:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppy ENOYL-COA HYDRATASE

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		5 GLY A  18
ALA A  20
ASP A  52
ILE A  53
GLN A 102
 None
 1.32A 3id5B-2ppyA:
undetectable		 3id5B-2ppyA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-2.6A)
 0.73A 3id5B-2pt6A:
10.8		 3id5B-2pt6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		5 GLY A 233
GLU A 258
ALA A 290
ASP A 341
ILE A 342
 UNL  A 414 (-4.0A)
None
UNL  A 414 (-3.9A)
None
UNL  A 414 (-3.1A)
 0.49A 3id5B-2py6A:
5.3		 3id5B-2py6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qik UPF0131 PROTEIN YKQA

(Bacillus
subtilis) 		PF06094
(GGACT)
PF13772
(AIG2_2) 		5 GLY A 255
GLU A 257
ASP A 139
ILE A 252
GLN A 249
 None
 1.19A 3id5B-2qikA:
undetectable		 3id5B-2qikA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		5 THR A 298
ASP A 379
ALA A 378
ILE A 333
GLN A 382
 None
 0.99A 3id5B-2qykA:
undetectable		 3id5B-2qykA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 GLY A 299
PHE A 302
ALA A 288
ASP A 226
ILE A 227
 None
None
None
SR  A 403 ( 2.2A)
None
 1.38A 3id5B-2xrmA:
undetectable		 3id5B-2xrmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0k PYROGLUTATMATE PORIN
OPDO

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 TYR A 182
GLY A 141
ASP A 140
ILE A 139
GLN A 137
 None
 1.25A 3id5B-2y0kA:
undetectable		 3id5B-2y0kA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLY A 362
ASP A 506
ASP A 361
ILE A 359
GLN A 377
 None
 1.22A 3id5B-2z1aA:
undetectable		 3id5B-2z1aA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		5 TYR A 114
GLY A  11
GLU A  12
ALA A  43
ILE A  14
 None
 1.25A 3id5B-3b8bA:
undetectable		 3id5B-3b8bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 TYR A 406
GLY A 519
THR A  14
ASP A 518
ILE A 517
 None
 1.28A 3id5B-3bmwA:
undetectable		 3id5B-3bmwA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co5 PUTATIVE
TWO-COMPONENT SYSTEM
TRANSCRIPTIONAL
RESPONSE REGULATOR

(Neisseria
gonorrhoeae) 		PF14532
(Sigma54_activ_2) 		5 TYR A 209
GLY A 211
ASP A 212
ILE A 213
GLN A 221
 None
 1.34A 3id5B-3co5A:
undetectable		 3id5B-3co5A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cql ENDOCHITINASE

(Carica papaya) 		PF00182
(Glyco_hydro_19) 		5 GLY A  45
GLU A  56
PHE A  60
ALA A  38
ILE A   2
 None
 1.26A 3id5B-3cqlA:
undetectable		 3id5B-3cqlA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		5 TYR A 321
GLY A 348
ALA A 380
ASP A 374
ILE A 375
 None
 1.22A 3id5B-3d5eA:
2.8		 3id5B-3d5eA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN
HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus;
Influenza A
virus) 		PF00509
(Hemagglutinin)
PF00509
(Hemagglutinin) 		5 GLY A  16
THR B  34
ASP B 112
ALA B   5
ILE B  10
 None
 1.29A 3id5B-3eykA:
undetectable		 3id5B-3eykA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		5 LYS A 599
GLY A 720
PHE A 716
ASP A 710
ILE A 709
 None
 1.29A 3id5B-3fqdA:
3.0		 3id5B-3fqdA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLY A  38
GLU A  59
ASP A  84
ALA A  85
ILE A  37
 None
 1.36A 3id5B-3fydA:
14.5		 3id5B-3fydA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLY A  38
THR A  45
GLU A  59
ASP A  84
ALA A  85
 None
 1.37A 3id5B-3fydA:
14.5		 3id5B-3fydA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 5 GLY A  94
GLU A 117
ASP A 144
ALA A 145
ASP A 163
 None
FMT  A 315 (-3.6A)
None
None
None
 0.74A 3id5B-3gjyA:
10.3		 3id5B-3gjyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLY A  38
THR A  45
GLU A  59
ASP A  84
ALA A  85
 SAM  A 300 (-3.3A)
None
SAM  A 300 (-2.8A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.6A)
 1.29A 3id5B-3gryA:
13.9		 3id5B-3gryA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE

(Xylella
fastidiosa) 		PF07221
(GlcNAc_2-epim) 		5 TYR A  90
ASP A  82
ALA A  83
ASP A  35
ILE A  34
 None
 1.15A 3id5B-3gt5A:
undetectable		 3id5B-3gt5A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 GLY A 867
THR A1400
ASP A 859
ASP A 868
ILE A 869
 None
 1.38A 3id5B-3h0gA:
undetectable		 3id5B-3h0gA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		5 TYR A 150
GLY A 227
THR A 102
ALA A 206
ILE A 228
 LEU  A 500 (-3.6A)
LEU  A 500 (-3.3A)
LEU  A 500 (-3.0A)
None
None
 1.27A 3id5B-3ipcA:
2.6		 3id5B-3ipcA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9x GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFC,
LINKER, ANCILLARY
PROTEIN KEFF

(Escherichia
coli) 		PF02254
(TrkA_N)
PF02525
(Flavodoxin_2) 		5 GLY A 406
THR A 414
ASP A 449
ALA A 450
ILE A 471
 None
 1.30A 3id5B-3l9xA:
8.2		 3id5B-3l9xA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m85 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Archaeoglobus
fulgidus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 GLY G  54
PHE G  32
ASP G 150
ALA G 151
ASP G  55
 None
 1.25A 3id5B-3m85G:
undetectable		 3id5B-3m85G:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdq EXOPOLYPHOSPHATASE

(Cytophaga
hutchinsonii) 		PF02541
(Ppx-GppA) 		5 GLY A 138
THR A  81
ALA A 275
ASP A 136
ILE A 137
 SO4  A 317 (-3.3A)
SO4  A 317 (-4.3A)
None
None
None
 1.33A 3id5B-3mdqA:
undetectable		 3id5B-3mdqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A 291
ALA A 267
ASP A 297
ILE A 298
GLN A 268
 None
 1.24A 3id5B-3mqtA:
undetectable		 3id5B-3mqtA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		5 GLY A  58
ASP A 137
ALA A 136
ASP A  62
ILE A  60
 None
MG  A 339 ( 2.5A)
GDD  A 340 (-3.6A)
None
None
 1.32A 3id5B-3o3pA:
undetectable		 3id5B-3o3pA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
horikoshii) 		PF03833
(PolC_DP2) 		5 GLY X 271
GLU X 273
ASP X 166
ASP X 268
ILE X 267
 None
 1.39A 3id5B-3o59X:
undetectable		 3id5B-3o59X:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvo NMRA FAMILY PROTEIN

(Shigella
flexneri) 		PF13460
(NAD_binding_10) 		5 THR A 204
ASP A 184
ALA A 180
ASP A 158
ILE A 157
 None
 1.27A 3id5B-3qvoA:
7.5		 3id5B-3qvoA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		5 GLY A 219
THR A 236
GLU A 277
ASP A 216
ILE A 270
 None
None
FB6  A 414 ( 4.0A)
MN  A 413 (-2.6A)
None
 1.25A 3id5B-3sl1A:
3.6		 3id5B-3sl1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		5 GLY A  46
THR A  53
GLU A  71
ASP A  94
ALA A  95
 None
 1.31A 3id5B-3uzuA:
11.9		 3id5B-3uzuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		5 GLY A  54
ALA A  83
ASP A 252
ILE A  53
GLN A  84
 None
 1.32A 3id5B-3vc1A:
11.5		 3id5B-3vc1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		5 GLY A 104
GLU A 133
ASP A 174
ALA A 175
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
 0.67A 3id5B-3vywA:
9.0		 3id5B-3vywA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		5 GLY A 771
PHE A 773
ALA A 365
ASP A 770
ILE A 772
 None
 1.29A 3id5B-4a0hA:
undetectable		 3id5B-4a0hA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Bos taurus) 		PF00118
(Cpn60_TCP1) 		5 GLY A 473
ALA A 455
ASP A 466
ILE A 472
GLN A 451
 None
 1.31A 3id5B-4a0wA:
undetectable		 3id5B-4a0wA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LYS A1789
GLY A1885
THR A1780
GLU A1928
ALA A1921
 None
 1.31A 3id5B-4bpcA:
undetectable		 3id5B-4bpcA:
17.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Pyrococcus
furiosus) 		PF01269
(Fibrillarin) 		7 LYS E  57
GLY E  81
THR E  87
ASP E 130
ALA E 131
ASP E 150
GLN E 153
 C  X   5 ( 2.7A)
None
C  X   6 ( 2.6A)
None
None
C  X   5 ( 3.2A)
G  A  24 ( 3.0A)
 1.09A 3id5B-4by9E:
30.4		 3id5B-4by9E:
51.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Pyrococcus
furiosus) 		PF01269
(Fibrillarin) 		9 LYS E  57
TYR E  79
GLY E  81
THR E  87
GLU E 105
PHE E 106
ASP E 130
ALA E 131
ASP E 150
 C  X   5 ( 2.7A)
None
None
C  X   6 ( 2.6A)
None
None
None
None
C  X   5 ( 3.2A)
 0.89A 3id5B-4by9E:
30.4		 3id5B-4by9E:
51.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Pyrococcus
furiosus) 		PF01269
(Fibrillarin) 		5 TYR E  79
PHE E 106
ASP E 130
ALA E 131
ILE E 159
 None
 1.33A 3id5B-4by9E:
30.4		 3id5B-4by9E:
51.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 TYR A 406
GLY A 518
THR A  14
ASP A 517
ILE A 516
 None
 1.36A 3id5B-4cgtA:
undetectable		 3id5B-4cgtA:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		5 LYS A  61
THR A  90
GLU A 109
ASP A 134
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-3.9A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.8A)
 1.30A 3id5B-4df3A:
32.3		 3id5B-4df3A:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		8 LYS A  61
TYR A  83
GLY A  85
GLU A 109
ASP A 134
ALA A 135
ASP A 154
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 0.53A 3id5B-4df3A:
32.3		 3id5B-4df3A:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		8 LYS A  61
TYR A  83
GLY A  85
THR A  91
ASP A 134
ALA A 135
ASP A 154
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 0.70A 3id5B-4df3A:
32.3		 3id5B-4df3A:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		5 TYR A 152
THR A  91
ALA A 135
ASP A 154
GLN A 157
 None
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 1.35A 3id5B-4df3A:
32.3		 3id5B-4df3A:
53.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		5 LYS A 158
GLY A 478
ASP A 325
ALA A 327
ASP A 477
 None
 1.37A 3id5B-4ia5A:
undetectable		 3id5B-4ia5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 LYS A 932
GLY A 754
THR A 934
ASP A 798
ILE A 797
 None
 1.04A 3id5B-4iugA:
undetectable		 3id5B-4iugA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 TYR A 407
GLY A 520
THR A  14
ASP A 519
ILE A 518
 None
 1.31A 3id5B-4jclA:
undetectable		 3id5B-4jclA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhm MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LYS A 115
ASP A 270
ALA A 271
ASP A 111
ILE A 107
 None
 1.29A 3id5B-4jhmA:
undetectable		 3id5B-4jhmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 5 GLY E 244
THR E 248
ASP E 298
ALA E 297
ASP E 255
 None
 1.32A 3id5B-4obuE:
undetectable		 3id5B-4obuE:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora) 		PF08801
(Nucleoporin_N) 		5 TYR A  72
THR A  69
ALA A 440
ASP A 462
ILE A 463
 None
 1.24A 3id5B-4q9tA:
undetectable		 3id5B-4q9tA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdi UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Acinetobacter
baumannii) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 GLY A 369
THR A 342
PHE A 403
ALA A 404
GLN A 402
 None
 1.15A 3id5B-4qdiA:
3.9		 3id5B-4qdiA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 LYS A 401
GLY A 360
ASP A 299
ALA A 300
ASP A 358
 None
None
None
SO4  A 907 (-4.7A)
None
 1.28A 3id5B-4qnlA:
undetectable		 3id5B-4qnlA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
MTA  A 401 (-3.6A)
4ZY  A 501 ( 3.6A)
 0.77A 3id5B-4uoeA:
10.4		 3id5B-4uoeA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztp LIGHT CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY L  68
ALA L  25
ASP L  30
ILE L  29
GLN L  27
 None
 1.21A 3id5B-4ztpL:
undetectable		 3id5B-4ztpL:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		5 GLY A  62
GLU A 110
PHE A  64
ALA A 112
ASP A  61
 None
 1.27A 3id5B-4zu2A:
undetectable		 3id5B-4zu2A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP1
VP3

(Foot-and-mouth
disease virus;
Foot-and-mouth
disease virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 TYR 3 171
THR 1 167
ASP 3  77
ALA 3  79
ASP 3 175
 None
 1.34A 3id5B-5aca3:
undetectable		 3id5B-5aca3:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		5 GLY A 111
GLU A 135
ASP A 163
ASP A 181
ILE A 182
 SAH  A 301 (-3.2A)
SAH  A 301 (-2.2A)
SAH  A 301 (-2.7A)
SAH  A 301 (-2.4A)
SAH  A 301 ( 3.8A)
 0.37A 3id5B-5ccxA:
15.6		 3id5B-5ccxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds0 PEPTIDASE M42

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF05343
(Peptidase_M42) 		5 GLY A 208
THR A 211
ASP A  39
ALA A  38
ILE A 192
 None
 1.39A 3id5B-5ds0A:
undetectable		 3id5B-5ds0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec1 ANTIBODY FAB
FRAGMENT LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  30
ALA B  25
ASP B  32
ILE B  29
GLN B  27
 None
 1.36A 3id5B-5ec1B:
undetectable		 3id5B-5ec1B:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		5 GLY B 118
GLU B 139
PHE B 140
ASP B 168
ASP B 203
 SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
SAM  B 401 (-4.8A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
 0.75A 3id5B-5ergB:
14.0		 3id5B-5ergB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr7 AMYR

(Erwinia
amylovora) 		PF10722
(YbjN) 		5 GLY A  44
PHE A  46
ALA A  61
ASP A  43
GLN A  40
 None
 1.25A 3id5B-5fr7A:
undetectable		 3id5B-5fr7A:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		6 LYS E  60
THR E  90
PHE E 109
ASP E 133
ALA E 134
ILE E 154
 U  I   4 ( 3.9A)
SAH  E 301 (-3.2A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 ( 4.4A)
 1.01A 3id5B-5ginE:
34.9		 3id5B-5ginE:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		10 LYS E  60
TYR E  82
GLY E  84
THR E  90
GLU E 108
ASP E 133
ALA E 134
ASP E 153
ILE E 154
GLN E 156
 U  I   4 ( 3.9A)
SAH  E 301 (-4.9A)
SAH  E 301 (-3.8A)
SAH  E 301 (-3.2A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 ( 4.4A)
SAH  E 301 (-3.8A)
 0.67A 3id5B-5ginE:
34.9		 3id5B-5ginE:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		6 TYR E 151
THR E  90
ALA E 134
ASP E 153
ILE E 154
GLN E 156
 None
SAH  E 301 (-3.2A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 ( 4.4A)
SAH  E 301 (-3.8A)
 1.40A 3id5B-5ginE:
34.9		 3id5B-5ginE:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens;
Homo sapiens) 		PF00443
(UCH)
PF00400
(WD40) 		5 GLY C 263
THR A 213
GLU A 283
ASP C 241
ASP C 283
 None
 1.27A 3id5B-5k1cC:
undetectable		 3id5B-5k1cC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 THR A 332
ASP A 413
ALA A 412
ILE A 367
GLN A 416
 None
 0.97A 3id5B-5ohjA:
undetectable		 3id5B-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TYR A1018
GLU A1011
PHE A1104
ASP A1070
ASP A1020
 None
 1.33A 3id5B-5t1aA:
undetectable		 3id5B-5t1aA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsq IUNH

(Leishmania
braziliensis) 		PF01156
(IU_nuc_hydro) 		5 THR A 126
ASP A  54
ALA A  53
ILE A  63
GLN A  50
 CA  A 401 ( 4.9A)
None
None
None
None
 1.30A 3id5B-5tsqA:
3.4		 3id5B-5tsqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 GLY A  64
THR A  90
ASP A  74
ALA A  73
ASP A  66
 None
 1.14A 3id5B-5u6sA:
3.2		 3id5B-5u6sA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekg CHEMOTAXIS PROTEIN
CHEY

(Methanococcus
maripaludis) 		no annotation 5 GLY Y  65
ASP Y  95
ALA Y  96
ASP Y  57
ILE Y  58
 None
None
None
MG  Y 201 (-2.5A)
None
 1.22A 3id5B-6ekgY:
undetectable		 3id5B-6ekgY:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER

(Geobacillus
kaustophilus) 		no annotation 5 GLY A 109
THR A 389
ASP A 111
ILE A 113
GLN A 325
 None
 1.27A 3id5B-6f34A:
undetectable		 3id5B-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 TYR D 224
GLY D 191
ALA D 238
ILE D 260
GLN D 313
 None
 1.27A 3id5B-6f5dD:
undetectable		 3id5B-6f5dD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 5 GLY B 511
THR B 612
GLU B 454
ALA B 458
ILE B 510
 None
 1.34A 3id5B-6fosB:
undetectable		 3id5B-6fosB:
undetectable