SIMILAR PATTERNS OF AMINO ACIDS FOR 3IB2_A_IBPA3960_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		4 GLY A 432
VAL A 591
GLY A 662
THR A 663
 None
 0.49A 3ib2A-1biyA:
40.9		 3ib2A-1biyA:
91.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0n TRIHYDROXYNAPHTHALEN
E REDUCTASE

(Magnaporthe
grisea) 		PF13561
(adh_short_C2) 		4 GLY A 163
VAL A 206
GLY A 272
THR A 271
 None
 0.87A 3ib2A-1g0nA:
0.7		 3ib2A-1g0nA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 GLY C 102
VAL C 105
GLY C  91
THR C  88
 None
 0.95A 3ib2A-1h2tC:
0.0		 3ib2A-1h2tC:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		4 GLY A 201
VAL A 147
GLY A 140
THR A 139
 None
 0.89A 3ib2A-1k7hA:
0.0		 3ib2A-1k7hA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		4 GLY H 197
VAL H 213
GLY H 136
THR H 135
 None
 0.92A 3ib2A-1kigH:
undetectable		 3ib2A-1kigH:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldi GLYCEROL UPTAKE
FACILITATOR PROTEIN

(Escherichia
coli) 		PF00230
(MIP) 		4 GLY A 227
VAL A 222
GLY A 133
THR A 134
 None
 0.69A 3ib2A-1ldiA:
0.0		 3ib2A-1ldiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjc MAJOR COLD-SHOCK
PROTEIN 7.4

(Escherichia
coli) 		PF00313
(CSD) 		4 GLY A  19
VAL A  32
GLY A   7
THR A   6
 None
 0.92A 3ib2A-1mjcA:
undetectable		 3ib2A-1mjcA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		4 GLY A 213
VAL A 224
GLY A 170
THR A 171
 ARG  A 703 ( 3.7A)
None
None
None
 0.81A 3ib2A-1pq5A:
undetectable		 3ib2A-1pq5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		4 GLY A  12
VAL A  97
GLY A 135
THR A 134
 None
None
4TP  A 332 ( 4.0A)
None
 0.72A 3ib2A-1ps6A:
0.0		 3ib2A-1ps6A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 GLY A 262
VAL A 320
GLY A 305
THR A 307
 None
 0.94A 3ib2A-1s0uA:
0.0		 3ib2A-1s0uA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  42
VAL A 326
GLY A 161
THR A 160
 None
 0.94A 3ib2A-1tt7A:
undetectable		 3ib2A-1tt7A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 GLY A  62
VAL A  82
GLY A  86
THR A  88
 None
None
PLP  A 510 (-3.4A)
PLP  A 510 (-3.6A)
 0.82A 3ib2A-1v2dA:
undetectable		 3ib2A-1v2dA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		4 GLY A 255
VAL A 253
GLY A 289
THR A 288
 None
CL  A1001 ( 4.8A)
None
None
 0.83A 3ib2A-1x1qA:
undetectable		 3ib2A-1x1qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk5 F17G ADHESIN SUBUNIT

(Escherichia
coli) 		PF09222
(Fim-adh_lectin) 		4 GLY A  39
VAL A 124
GLY A  94
THR A  95
 None
 0.89A 3ib2A-1zk5A:
undetectable		 3ib2A-1zk5A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		4 GLY A 170
VAL A 168
GLY A 157
THR A 158
 None
 0.80A 3ib2A-1zypA:
undetectable		 3ib2A-1zypA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5d GNA33

(Neisseria
gonorrhoeae) 		PF03562
(MltA)
PF06725
(3D) 		4 GLY A 129
VAL A 127
GLY A 425
THR A 376
 None
 0.84A 3ib2A-2g5dA:
undetectable		 3ib2A-2g5dA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus) 		PF01112
(Asparaginase_2) 		4 GLY A  38
VAL A  51
GLY B 195
THR B 209
 None
 0.89A 3ib2A-2gezA:
undetectable		 3ib2A-2gezA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hst EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Homo sapiens) 		PF03464
(eRF1_2) 		4 GLY A 228
VAL A 150
GLY A 155
THR A 173
 None
 0.76A 3ib2A-2hstA:
undetectable		 3ib2A-2hstA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iab HYPOTHETICAL PROTEIN

(Streptomyces
avermitilis) 		PF01243
(Putative_PNPOx) 		4 GLY A  75
VAL A  28
GLY A  87
THR A  88
 None
 0.94A 3ib2A-2iabA:
undetectable		 3ib2A-2iabA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jz4 JASMONATE INDUCIBLE
PROTEIN ISOLOG

(Arabidopsis
thaliana) 		PF01419
(Jacalin) 		4 GLY A 207
VAL A 190
GLY A 186
THR A 245
 None
 0.85A 3ib2A-2jz4A:
undetectable		 3ib2A-2jz4A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 GLY A 222
VAL A 226
GLY A 135
THR A 136
 MPD  A 252 ( 4.2A)
None
UDP  A 250 (-3.4A)
UDP  A 250 (-2.8A)
 0.88A 3ib2A-2pnzA:
undetectable		 3ib2A-2pnzA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF01823
(MACPF) 		4 GLY A 234
VAL A 220
GLY A 194
THR A 193
 None
 0.86A 3ib2A-2qqhA:
undetectable		 3ib2A-2qqhA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica) 		PF13416
(SBP_bac_8) 		4 GLY A 170
VAL A 237
GLY A 265
THR A 266
 None
 0.93A 3ib2A-2uvjA:
4.9		 3ib2A-2uvjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 GLY A  42
VAL A  39
GLY A 186
THR A 185
 MCL  A 161 ( 3.4A)
None
MCL  A 161 ( 3.7A)
None
 0.88A 3ib2A-2vc6A:
undetectable		 3ib2A-2vc6A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		4 GLY A 212
VAL A 210
GLY A 665
THR A 664
 None
 0.90A 3ib2A-2ww8A:
undetectable		 3ib2A-2ww8A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 GLY A 514
VAL A 517
GLY A 374
THR A 375
 QPS  A1050 ( 4.0A)
None
None
None
 0.92A 3ib2A-2x2iA:
undetectable		 3ib2A-2x2iA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x46 ALLERGEN ARG R 1

(Argas reflexus) 		PF02098
(His_binding) 		4 GLY A  70
VAL A  53
GLY A  83
THR A  84
 None
TRS  A1160 (-4.1A)
None
None
 0.93A 3ib2A-2x46A:
undetectable		 3ib2A-2x46A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 GLY A 129
VAL A 120
GLY A  95
THR A  94
 None
 0.86A 3ib2A-2xsgA:
undetectable		 3ib2A-2xsgA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zal L-ASPARAGINASE

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		4 GLY A  39
VAL A  52
GLY B 181
THR B 195
 None
 0.85A 3ib2A-2zalA:
undetectable		 3ib2A-2zalA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		4 GLY A  76
VAL A 102
GLY A 106
THR A 108
 None
None
PMP  A 409 (-2.8A)
PMP  A 409 (-3.6A)
 0.93A 3ib2A-2zc0A:
undetectable		 3ib2A-2zc0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		4 GLY A 450
VAL A 389
GLY A 148
THR A 128
 None
 0.95A 3ib2A-3a2qA:
1.5		 3ib2A-3a2qA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE

(Shewanella sp.
AP1) 		PF00245
(Alk_phosphatase) 		4 GLY A 142
VAL A 107
GLY A 100
THR A  99
 None
 0.90A 3ib2A-3a52A:
1.3		 3ib2A-3a52A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aco PROTEIN KINASE C AND
CASEIN KINASE
SUBSTRATE IN NEURONS
PROTEIN 2

(Homo sapiens) 		PF00611
(FCH) 		4 GLY A  73
VAL A  70
GLY A  77
THR A  78
 None
 0.90A 3ib2A-3acoA:
undetectable		 3ib2A-3acoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awd PUTATIVE POLYOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF13561
(adh_short_C2) 		4 GLY A 146
VAL A 190
GLY A 245
THR A 244
 None
 0.93A 3ib2A-3awdA:
undetectable		 3ib2A-3awdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c17 L-ASPARAGINASE
PRECURSOR

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		4 GLY A  39
VAL A  52
GLY A 181
THR A 195
 None
 0.83A 3ib2A-3c17A:
undetectable		 3ib2A-3c17A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		4 GLY A 438
VAL A 440
GLY A  83
THR A  84
 None
 0.77A 3ib2A-3dc8A:
undetectable		 3ib2A-3dc8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehc SNOAL-LIKE
POLYKETIDE CYCLASE

(Agrobacterium
fabrum) 		PF07366
(SnoaL) 		4 GLY A  39
VAL A  31
GLY A  24
THR A  25
 None
 0.92A 3ib2A-3ehcA:
undetectable		 3ib2A-3ehcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 GLY A 271
VAL A 308
GLY A 293
THR A 294
 None
 0.66A 3ib2A-3ehmA:
undetectable		 3ib2A-3ehmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3el6 ERYTHROMYCIN
DEHYDRATASE

(Saccharopolyspora
erythraea) 		PF14765
(PS-DH) 		4 GLY A  54
VAL A  58
GLY A 128
THR A 129
 None
 0.91A 3ib2A-3el6A:
undetectable		 3ib2A-3el6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00877
(NLPC_P60) 		4 GLY A 145
VAL A 200
GLY A 139
THR A 166
 None
 0.90A 3ib2A-3gt2A:
undetectable		 3ib2A-3gt2A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3haj HUMAN PACSIN2 F-BAR

(Homo sapiens) 		PF00611
(FCH) 		4 GLY A  74
VAL A  71
GLY A  78
THR A  79
 CA  A 488 (-4.3A)
None
None
None
 0.94A 3ib2A-3hajA:
undetectable		 3ib2A-3hajA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		4 GLY A 227
VAL A 124
GLY A  95
THR A  97
 None
None
NAD  A 402 (-3.2A)
None
 0.81A 3ib2A-3hl0A:
undetectable		 3ib2A-3hl0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i50 MURINE HEAVY CHAIN
(IGG3) OF E53
MONOCLONAL ANTIBODY
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  10
VAL H 109
GLY H  16
THR H  82
 None
 0.93A 3ib2A-3i50H:
undetectable		 3ib2A-3i50H:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		4 GLY A 230
VAL A 127
GLY A  98
THR A 100
 None
None
NAD  A 400 (-3.1A)
None
 0.77A 3ib2A-3jzdA:
undetectable		 3ib2A-3jzdA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9c TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF13377
(Peripla_BP_3) 		4 GLY A 278
VAL A 249
GLY A 224
THR A 223
 None
 0.85A 3ib2A-3k9cA:
undetectable		 3ib2A-3k9cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3w PROTEIN KINASE C AND
CASEIN KINASE II
SUBSTRATE PROTEIN 3

(Mus musculus) 		PF00611
(FCH) 		4 GLY A  71
VAL A  68
GLY A  75
THR A  76
 None
 0.85A 3ib2A-3m3wA:
undetectable		 3ib2A-3m3wA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mep UNCHARACTERIZED
PROTEIN ECA2234

(Pectobacterium
atrosepticum) 		PF07081
(DUF1349) 		4 GLY A 167
VAL A  54
GLY A  86
THR A  87
 None
 0.84A 3ib2A-3mepA:
undetectable		 3ib2A-3mepA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB

(Thermus
thermophilus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A  39
VAL A  41
GLY A   8
THR A   7
 None
None
NAD  A 311 (-3.4A)
NAD  A 311 ( 4.3A)
 0.90A 3ib2A-3oa0A:
undetectable		 3ib2A-3oa0A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		4 GLY A 296
VAL A 329
GLY A 322
THR A 321
 AP5  A 346 (-3.2A)
None
None
None
 0.80A 3ib2A-3otxA:
undetectable		 3ib2A-3otxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A 322
VAL A 361
GLY A 385
THR A 386
 None
 0.85A 3ib2A-3p4xA:
undetectable		 3ib2A-3p4xA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv2 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLY A 291
VAL A 274
GLY A 271
THR A 303
 None
 0.92A 3ib2A-3pv2A:
undetectable		 3ib2A-3pv2A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLY A 291
VAL A 274
GLY A 271
THR A 303
 None
 0.87A 3ib2A-3pv4A:
undetectable		 3ib2A-3pv4A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		4 GLY A  91
VAL A  96
GLY A  85
THR A  84
 None
 0.92A 3ib2A-3rl3A:
undetectable		 3ib2A-3rl3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 GLY X 426
VAL X 429
GLY X 169
THR X 168
 None
 0.60A 3ib2A-3ss7X:
undetectable		 3ib2A-3ss7X:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF13561
(adh_short_C2) 		4 GLY A  46
VAL A  48
GLY A  14
THR A  13
 None
None
CL  A 279 (-3.7A)
None
 0.88A 3ib2A-3svtA:
undetectable		 3ib2A-3svtA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF00106
(adh_short) 		4 GLY A  39
VAL A  43
GLY A  18
THR A  21
 None
 0.65A 3ib2A-3tl3A:
undetectable		 3ib2A-3tl3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLY A 342
VAL A 323
GLY A  23
THR A  24
 None
 0.92A 3ib2A-3wheA:
undetectable		 3ib2A-3wheA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wya ELONGATION FACTOR
1-ALPHA

(Pyrococcus
horikoshii) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 GLY A 367
VAL A 362
GLY A 380
THR A 379
 None
 0.91A 3ib2A-3wyaA:
undetectable		 3ib2A-3wyaA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae) 		PF00291
(PALP) 		4 GLY A  72
VAL A  74
GLY A 177
THR A 179
 None
None
PLP  A 401 (-3.8A)
None
 0.84A 3ib2A-3x43A:
undetectable		 3ib2A-3x43A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 605
VAL A 193
GLY A 138
THR A 137
 None
 0.84A 3ib2A-3zz1A:
undetectable		 3ib2A-3zz1A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 GLY A 517
VAL A 529
GLY A 496
THR A 497
 None
None
GOL  A 630 (-3.5A)
GOL  A 630 (-4.0A)
 0.87A 3ib2A-4bjpA:
undetectable		 3ib2A-4bjpA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bne PROTEIN KINASE C AND
CASEIN KINASE
SUBSTRATE IN NEURONS
PROTEIN 2

(Gallus gallus) 		PF00611
(FCH) 		4 GLY A  73
VAL A  70
GLY A  77
THR A  78
 None
 0.91A 3ib2A-4bneA:
undetectable		 3ib2A-4bneA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dam SINGLE-STRANDED
DNA-BINDING PROTEIN
1

(Streptomyces
coelicolor) 		PF00436
(SSB) 		4 GLY A  10
VAL A  75
GLY A 110
THR A 111
 None
 0.84A 3ib2A-4damA:
undetectable		 3ib2A-4damA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 GLY A 322
VAL A 361
GLY A 385
THR A 386
 None
 0.76A 3ib2A-4ddwA:
undetectable		 3ib2A-4ddwA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 GLY A 123
VAL A 165
GLY A 229
THR A 228
 None
 0.90A 3ib2A-4e4yA:
undetectable		 3ib2A-4e4yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 GLY A 518
VAL A  42
GLY A 392
THR A 496
 None
 0.79A 3ib2A-4fffA:
undetectable		 3ib2A-4fffA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		4 GLY A 517
VAL A 500
GLY A 497
THR A 529
 None
 0.92A 3ib2A-4fgmA:
undetectable		 3ib2A-4fgmA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		4 GLY A 432
VAL A 591
GLY A 662
THR A 663
 CEL  A 711 (-3.7A)
None
CEL  A 711 (-3.3A)
None
 0.41A 3ib2A-4fimA:
58.0		 3ib2A-4fimA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0o ACETATE KINASE

(Entamoeba
histolytica) 		PF00871
(Acetate_kinase) 		4 GLY A 234
VAL A 228
GLY A 202
THR A 201
 None
 0.94A 3ib2A-4h0oA:
undetectable		 3ib2A-4h0oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		4 GLY A 212
VAL A 215
GLY A 190
THR A 192
 None
 0.92A 3ib2A-4h7nA:
undetectable		 3ib2A-4h7nA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 GLY A 201
VAL A 149
GLY A 227
THR A 229
 None
None
None
1ED  A 406 (-4.3A)
 0.91A 3ib2A-4ictA:
undetectable		 3ib2A-4ictA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 GLY B 222
VAL B 225
GLY B 113
THR B 112
 None
 0.93A 3ib2A-4o9uB:
undetectable		 3ib2A-4o9uB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Phaseolus
vulgaris) 		PF01112
(Asparaginase_2) 		4 GLY A  37
VAL A  50
GLY B 198
THR B 212
 None
 0.84A 3ib2A-4pu6A:
undetectable		 3ib2A-4pu6A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 GLY A 261
VAL A 259
GLY A 330
THR A 329
 None
 0.85A 3ib2A-4qbuA:
undetectable		 3ib2A-4qbuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		4 GLY A 516
VAL A 548
GLY A 484
THR A 485
 None
 0.91A 3ib2A-4u3tA:
undetectable		 3ib2A-4u3tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		4 GLY A 656
VAL A 654
GLY A 702
THR A 701
 None
 0.73A 3ib2A-4u48A:
undetectable		 3ib2A-4u48A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3) 		4 GLY A 170
VAL A 168
GLY A 157
THR A 158
 None
 0.72A 3ib2A-4xvgA:
undetectable		 3ib2A-4xvgA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLY A 288
VAL A 271
GLY A 268
THR A 300
 None
 0.88A 3ib2A-4ynnA:
undetectable		 3ib2A-4ynnA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo1 DEGQ

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLY A 288
VAL A 271
GLY A 268
THR A 300
 None
 0.88A 3ib2A-4yo1A:
undetectable		 3ib2A-4yo1A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 GLY A 664
VAL A 662
GLY A 710
THR A 709
 None
 0.91A 3ib2A-5a42A:
undetectable		 3ib2A-5a42A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0h LEUKOCYTE
CELL-DERIVED
CHEMOTAXIN-2

(Homo sapiens) 		PF01551
(Peptidase_M23) 		4 GLY A  58
VAL A  73
GLY A  54
THR A  53
 None
 0.77A 3ib2A-5b0hA:
undetectable		 3ib2A-5b0hA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erd DESMOGLEIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		4 GLY A 230
VAL A 241
GLY A 283
THR A 276
 None
 0.92A 3ib2A-5erdA:
undetectable		 3ib2A-5erdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 756
VAL A 238
GLY A 170
THR A 169
 None
 0.94A 3ib2A-5fjiA:
undetectable		 3ib2A-5fjiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 216
VAL A 219
GLY A 270
THR A 271
 None
 0.93A 3ib2A-5h80A:
undetectable		 3ib2A-5h80A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		4 GLY A 349
VAL A 353
GLY A 289
THR A 292
 None
 0.81A 3ib2A-5hy4A:
undetectable		 3ib2A-5hy4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I) 		4 GLY A  28
VAL A  65
GLY A  72
THR A  73
 HEB  A 502 ( 4.0A)
HEB  A 502 (-3.4A)
HEB  A 502 (-3.4A)
HEB  A 502 (-4.6A)
 0.92A 3ib2A-5ir6A:
undetectable		 3ib2A-5ir6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd8 PERIPLASMIC SERINE
PEPTIDASE DEGS

(Yersinia pestis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLY A 300
VAL A 283
GLY A 280
THR A 312
 None
 0.82A 3ib2A-5jd8A:
undetectable		 3ib2A-5jd8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 748
VAL A 234
GLY A 169
THR A 168
 None
 0.89A 3ib2A-5ju6A:
undetectable		 3ib2A-5ju6A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel EBOLA SURFACE
GLYCOPROTEIN, GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		4 GLY A 143
VAL A 141
GLY A 173
THR A 174
 None
 0.93A 3ib2A-5kelA:
undetectable		 3ib2A-5kelA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 GLY A 516
VAL A 548
GLY A 484
THR A 485
 None
 0.87A 3ib2A-5kshA:
undetectable		 3ib2A-5kshA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A  39
VAL A  35
GLY A  65
THR A  62
 None
 0.79A 3ib2A-5lewA:
undetectable		 3ib2A-5lewA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Chlamydomonas
reinhardtii) 		PF00400
(WD40) 		4 GLY A 228
VAL A 237
GLY A 275
THR A 276
 None
 0.83A 3ib2A-5mzhA:
undetectable		 3ib2A-5mzhA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 GLY A 863
VAL A 846
GLY A 817
THR A 792
 CA  A9011 ( 4.7A)
None
None
None
 0.95A 3ib2A-5n8pA:
undetectable		 3ib2A-5n8pA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 GLY A 863
VAL A 846
GLY A 817
THR A 792
 CA  A9011 ( 4.7A)
None
None
None
 0.94A 3ib2A-5n97A:
undetectable		 3ib2A-5n97A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 GLY B 222
VAL B 225
GLY B 113
THR B 112
 None
BEN  B 310 (-4.3A)
PEG  B 306 (-3.6A)
None
 0.94A 3ib2A-5uniB:
undetectable		 3ib2A-5uniB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vod FAB 9I6 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  45
VAL H  21
GLY H 118
THR H 119
 None
 0.93A 3ib2A-5vodH:
undetectable		 3ib2A-5vodH:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx3 ALKYLDIKETIDE-COA
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 300
VAL A 303
GLY A 368
THR A 372
 COA  A 401 ( 3.7A)
None
None
None
 0.86A 3ib2A-5wx3A:
undetectable		 3ib2A-5wx3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Geobacillus sp.
12AMOR1) 		no annotation 4 GLY A  10
VAL A   8
GLY A  31
THR A  30
 None
 0.68A 3ib2A-5xksA:
undetectable		 3ib2A-5xksA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
LUMINAL EXTRINSIC
PROTEIN TN, PSBTN

(Pisum sativum) 		no annotation 4 GLY B 278
VAL U  16
GLY U   5
THR U   6
 None
 0.91A 3ib2A-5xnmB:
undetectable		 3ib2A-5xnmB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 4 GLY A 313
VAL A 316
GLY A 457
THR A 458
 C3H  A 514 (-3.3A)
None
None
None
 0.90A 3ib2A-6exsA:
undetectable		 3ib2A-6exsA:
10.17