SIMILAR PATTERNS OF AMINO ACIDS FOR 3IB1_A_IMNA701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)


(Ochrobactrum
anthropi)
PF03576
(Peptidase_S58)
4 PRO A  25
THR A  23
GLY A 196
THR A 195
None
1.06A 3ib1A-1b65A:
undetectable
3ib1A-1b65A:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1biy LACTOFERRIN

(Bubalus bubalis)
PF00405
(Transferrin)
4 PRO A 429
THR A 430
GLY A 662
THR A 663
None
0.58A 3ib1A-1biyA:
40.7
3ib1A-1biyA:
91.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1j PROFILIN II

(Homo sapiens)
PF00235
(Profilin)
4 PRO A  96
THR A  97
GLY A 120
THR A 122
None
None
SO4  A 800 (-3.6A)
None
1.15A 3ib1A-1d1jA:
undetectable
3ib1A-1d1jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7b CELLOBIOSE
DEHYDROGENASE


(Phanerochaete
chrysosporium)
PF16010
(CDH-cyt)
4 PRO A  93
THR A  94
GLY A  98
THR A  99
HEM  A 401 (-4.5A)
None
None
None
1.14A 3ib1A-1d7bA:
undetectable
3ib1A-1d7bA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlp LECTIN SCAFET
PRECURSOR


(Hyacinthoides
hispanica)
PF01453
(B_lectin)
4 PRO A  14
THR A  16
GLY A  57
THR A  56
None
1.10A 3ib1A-1dlpA:
undetectable
3ib1A-1dlpA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN


(Homo sapiens)
PF00766
(ETF_alpha)
PF01012
(ETF)
4 PRO A  35
THR A  37
GLY A  57
THR A  58
None
1.14A 3ib1A-1efvA:
0.0
3ib1A-1efvA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdi L-RIBULOSE 5
PHOSPHATE
4-EPIMERASE


(Escherichia
coli)
PF00596
(Aldolase_II)
4 PRO A  78
THR A  79
GLY A 172
THR A 102
None
1.13A 3ib1A-1jdiA:
undetectable
3ib1A-1jdiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens)
PF00102
(Y_phosphatase)
4 PRO A1335
THR A1555
GLY A1530
THR A1529
None
1.10A 3ib1A-1larA:
0.0
3ib1A-1larA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING


(Thermotoga
maritima)
PF00465
(Fe-ADH)
4 PRO A 135
THR A 137
GLY A 271
THR A 274
None
NAP  A1800 (-2.9A)
None
None
1.08A 3ib1A-1o2dA:
0.3
3ib1A-1o2dA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE


(Bacillus
subtilis)
PF05448
(AXE1)
4 PRO C 274
THR C 272
GLY C 179
THR C 178
None
1.18A 3ib1A-1odtC:
undetectable
3ib1A-1odtC:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE


(Haemophilus
influenzae)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 PRO A 350
THR A 351
GLY A 128
THR A 130
None
1.17A 3ib1A-1p31A:
undetectable
3ib1A-1p31A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE


(Trichoderma
reesei)
PF00150
(Cellulase)
4 PRO A 244
THR A 249
GLY A 212
THR A 211
None
1.12A 3ib1A-1qnrA:
undetectable
3ib1A-1qnrA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor)
PF00232
(Glyco_hydro_1)
4 PRO A 205
THR A  53
GLY A 109
THR A 110
None
1.17A 3ib1A-1v02A:
undetectable
3ib1A-1v02A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs3 TRNA PSEUDOURIDINE
SYNTHASE A


(Thermus
thermophilus)
PF01416
(PseudoU_synth_1)
4 PRO A 232
THR A 233
GLY A  54
THR A  13
None
1.01A 3ib1A-1vs3A:
undetectable
3ib1A-1vs3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtl TATA BINDING PROTEIN
(TBP)


(Arabidopsis
thaliana)
PF00352
(TBP)
4 PRO E  23
THR E  24
GLY E  83
THR E  82
None
1.11A 3ib1A-1vtlE:
undetectable
3ib1A-1vtlE:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE


(Homo sapiens)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
4 PRO A 344
THR A 346
GLY A 317
THR A 318
PRO  A 344 ( 1.1A)
THR  A 346 ( 0.8A)
GLY  A 317 ( 0.0A)
THR  A 318 ( 0.8A)
1.14A 3ib1A-1wsvA:
undetectable
3ib1A-1wsvA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION


(Saccharomyces
cerevisiae)
PF02567
(PhzC-PhzF)
4 PRO A  73
THR A  72
GLY A 159
THR A 158
None
1.19A 3ib1A-1ym5A:
undetectable
3ib1A-1ym5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME


(Rattus
norvegicus)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
4 PRO A 283
THR A 282
GLY A 429
THR A 407
None
1.16A 3ib1A-1zcjA:
2.3
3ib1A-1zcjA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyl HYPOTHETICAL PROTEIN
YIHE


(Escherichia
coli)
PF01636
(APH)
4 PRO A 145
THR A 146
GLY A 136
THR A 135
None
1.18A 3ib1A-1zylA:
undetectable
3ib1A-1zylA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa1 HEMOGLOBIN BETA-C
CHAIN


(Trematomus
newnesi)
PF00042
(Globin)
4 PRO B  36
THR B  38
GLY B  64
THR B  65
None
HEM  B 400 (-4.1A)
None
None
1.11A 3ib1A-2aa1B:
undetectable
3ib1A-2aa1B:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csp RIM BINDING PROTEIN
2


(Homo sapiens)
no annotation 4 PRO A  20
THR A  97
GLY A  48
THR A  47
None
1.03A 3ib1A-2cspA:
undetectable
3ib1A-2cspA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN


(Escherichia
coli)
PF02635
(DrsE)
4 PRO A  53
THR A  51
GLY A  43
THR A   8
None
1.15A 3ib1A-2d1pA:
undetectable
3ib1A-2d1pA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6l LECTIN, GALACTOSE
BINDING, SOLUBLE 9


(Mus musculus)
PF00337
(Gal-bind_lectin)
4 PRO X   9
THR X 145
GLY X  35
THR X  36
None
1.18A 3ib1A-2d6lX:
undetectable
3ib1A-2d6lX:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus)
PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C)
4 PRO A 110
THR A 108
GLY A 100
THR A 101
None
1.19A 3ib1A-2e28A:
undetectable
3ib1A-2e28A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV


(Stenotrophomonas
maltophilia)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
4 PRO A 500
THR A 499
GLY A 358
THR A 357
None
0.97A 3ib1A-2ecfA:
undetectable
3ib1A-2ecfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE


(Desulfovibrio
desulfuricans)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
4 PRO A 419
THR A 422
GLY A 345
THR A 344
None
MGD  A 811 (-2.5A)
MGD  A 812 (-3.1A)
None
0.80A 3ib1A-2jirA:
undetectable
3ib1A-2jirA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1


(Rhodobacter
capsulatus)
PF00072
(Response_reg)
4 PRO A  75
THR A  77
GLY A  63
THR A  62
None
1.18A 3ib1A-2jk1A:
2.5
3ib1A-2jk1A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l1t UNCHARACTERIZED
PROTEIN


(Geobacter
sulfurreducens)
no annotation 4 PRO A  57
THR A  59
GLY A  33
THR A  34
None
1.09A 3ib1A-2l1tA:
undetectable
3ib1A-2l1tA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE


(Methanocaldococcus
jannaschii)
PF12804
(NTP_transf_3)
4 PRO A  51
THR A  53
GLY A  11
THR A  12
None
1.13A 3ib1A-2mzbA:
undetectable
3ib1A-2mzbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR


(Pseudomonas
aeruginosa)
PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug)
4 PRO A 464
THR A 462
GLY A 138
THR A 139
None
1.16A 3ib1A-2o5pA:
undetectable
3ib1A-2o5pA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus)
PF00270
(DEAD)
PF00271
(Helicase_C)
4 PRO A 476
THR A 477
GLY A 493
THR A 492
None
0.97A 3ib1A-2p6rA:
undetectable
3ib1A-2p6rA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN


(Rhizobium etli)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 PRO A 831
THR A 751
GLY A 550
THR A 546
None
0.99A 3ib1A-2qf7A:
2.0
3ib1A-2qf7A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v35 ELASTASE-1

(Sus scrofa)
PF00089
(Trypsin)
4 PRO A 225
THR A 226
GLY A  19
THR A  20
None
1.11A 3ib1A-2v35A:
undetectable
3ib1A-2v35A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A


(Deinococcus
radiodurans)
PF00005
(ABC_tran)
4 PRO A 236
THR A 239
GLY A 253
THR A 254
None
1.04A 3ib1A-2vf8A:
undetectable
3ib1A-2vf8A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D


(Streptococcus
pneumoniae)
PF03644
(Glyco_hydro_85)
4 PRO A 269
THR A 270
GLY A 536
THR A 535
None
1.19A 3ib1A-2w92A:
undetectable
3ib1A-2w92A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 PRO A 848
THR A 849
GLY A 702
THR A 701
None
SO4  A1933 (-4.2A)
None
None
1.16A 3ib1A-2wanA:
undetectable
3ib1A-2wanA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN


(Porcine
mastadenovirus
B)
PF00337
(Gal-bind_lectin)
4 PRO A 495
THR A 490
GLY A 405
THR A 404
None
1.06A 3ib1A-2wsuA:
undetectable
3ib1A-2wsuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B


(Thermosynechococcus
elongatus)
PF00148
(Oxidored_nitro)
4 PRO B 246
THR B 245
GLY B 226
THR B 229
None
1.08A 3ib1A-2xdqB:
undetectable
3ib1A-2xdqB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1


(Sus scrofa)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase)
4 PRO A 604
THR A 391
GLY A 627
THR A 702
None
1.16A 3ib1A-2yn9A:
undetectable
3ib1A-2yn9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq1 ORF73

(Murid
gammaherpesvirus
4)
no annotation 4 PRO A 179
THR A 181
GLY A 247
THR A 248
None
1.04A 3ib1A-2yq1A:
undetectable
3ib1A-2yq1A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zw4 BLEOMYCIN
ACETYLTRANSFERASE


(Streptomyces
verticillus)
PF13302
(Acetyltransf_3)
4 PRO A 226
THR A 225
GLY A 255
THR A 256
None
1.11A 3ib1A-2zw4A:
undetectable
3ib1A-2zw4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE


(Arthrobacter
sp. KI72)
PF01425
(Amidase)
4 PRO A 387
THR A 388
GLY A 148
THR A 128
None
0.92A 3ib1A-3a2qA:
1.7
3ib1A-3a2qA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale)
PF00232
(Glyco_hydro_1)
4 PRO A 207
THR A  57
GLY A 113
THR A 114
None
0.97A 3ib1A-3aivA:
undetectable
3ib1A-3aivA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bk3 CROSSVEINLESS 2

(Danio rerio)
no annotation 4 PRO C  19
THR C  22
GLY C  58
THR C  57
None
0.91A 3ib1A-3bk3C:
undetectable
3ib1A-3bk3C:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE


(Xanthomonas
campestris)
PF08450
(SGL)
4 PRO A 208
THR A 207
GLY A 257
THR A 258
None
1.17A 3ib1A-3dr2A:
undetectable
3ib1A-3dr2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440


(Streptococcus
pneumoniae)
PF03644
(Glyco_hydro_85)
4 PRO A 269
THR A 270
GLY A 536
THR A 535
None
1.17A 3ib1A-3gdbA:
undetectable
3ib1A-3gdbA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 PRO A 150
THR A 152
GLY A 123
THR A  59
None
1.11A 3ib1A-3jv7A:
undetectable
3ib1A-3jv7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A


(Glaesserella
parasuis)
PF00496
(SBP_bac_5)
4 PRO A 196
THR A 198
GLY A  37
THR A  36
None
1.01A 3ib1A-3m8uA:
2.4
3ib1A-3m8uA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A


(Glaesserella
parasuis)
PF00496
(SBP_bac_5)
4 PRO A 196
THR A 198
GLY A 205
THR A 206
None
1.00A 3ib1A-3m8uA:
2.4
3ib1A-3m8uA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw4 NEUREXIN-2-BETA

(Mus musculus)
PF02210
(Laminin_G_2)
4 PRO A 104
THR A 207
GLY A 153
THR A 154
None
None
CA  A   1 ( 4.2A)
None
1.06A 3ib1A-3mw4A:
undetectable
3ib1A-3mw4A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1


(Sus scrofa)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
4 PRO A 588
THR A 375
GLY A 611
THR A 686
None
None
PHD  A 369 ( 4.5A)
None
1.11A 3ib1A-3n23A:
undetectable
3ib1A-3n23A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5c CYTOCHROME C551
PEROXIDASE


(Shewanella
oneidensis)
PF00034
(Cytochrom_C)
PF03150
(CCP_MauG)
4 PRO A 252
THR A 253
GLY A  69
THR A  68
HEM  A 501 (-4.3A)
None
None
None
0.77A 3ib1A-3o5cA:
undetectable
3ib1A-3o5cA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
4 PRO A 278
THR A 280
GLY A 240
THR A 242
None
1.16A 3ib1A-3ogrA:
undetectable
3ib1A-3ogrA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7m MALATE DEHYDROGENASE

(Francisella
tularensis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 PRO A 286
THR A 277
GLY A 175
THR A 179
None
0.99A 3ib1A-3p7mA:
1.8
3ib1A-3p7mA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3


(Coxiella
burnetii)
PF00009
(GTP_EFTU)
PF16658
(RF3_C)
4 PRO A 133
THR A 132
GLY A 385
THR A 384
None
1.14A 3ib1A-3tr5A:
undetectable
3ib1A-3tr5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE


(Mycobacterium
marinum)
no annotation 4 PRO B  40
THR B  42
GLY B  20
THR B  23
None
1.15A 3ib1A-3tzqB:
undetectable
3ib1A-3tzqB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 PRO A 235
THR A 237
GLY A 296
THR A 299
None
1.09A 3ib1A-3u4aA:
undetectable
3ib1A-3u4aA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN


(Vigna
unguiculata)
PF00182
(Glyco_hydro_19)
4 PRO A 115
THR A  65
GLY A  46
THR A  47
None
1.13A 3ib1A-3w3eA:
undetectable
3ib1A-3w3eA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N)
4 PRO A 776
THR A 775
GLY A 651
THR A 648
None
1.07A 3ib1A-3welA:
undetectable
3ib1A-3welA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6


(Homo sapiens)
PF02146
(SIR2)
4 PRO A  89
THR A  90
GLY A 212
THR A 213
None
None
APR  A1296 (-3.6A)
APR  A1296 (-3.7A)
1.05A 3ib1A-3zg6A:
undetectable
3ib1A-3zg6A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1
TRANSLATION
MACHINERY-ASSOCIATED
PROTEIN 46


(Saccharomyces
cerevisiae)
PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16543
(DFRP_C)
PF16897
(MMR_HSR1_Xtn)
4 PRO A 300
THR A 365
GLY C 272
THR C 271
None
1.14A 3ib1A-4a9aA:
undetectable
3ib1A-4a9aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S


(Homo sapiens)
PF00102
(Y_phosphatase)
4 PRO A1402
THR A1622
GLY A1597
THR A1596
None
None
None
CSO  A1589 ( 4.0A)
1.13A 3ib1A-4bpcA:
undetectable
3ib1A-4bpcA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1


(Homo sapiens)
PF00400
(WD40)
PF03451
(HELP)
4 PRO A 505
THR A 521
GLY A 529
THR A 530
None
1.17A 3ib1A-4ci8A:
undetectable
3ib1A-4ci8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgu PUTATIVE CELL
ADHESION PROTEIN


(Bacteroides
thetaiotaomicron)
no annotation 4 PRO A 211
THR A 149
GLY A 130
THR A 131
None
1.06A 3ib1A-4dguA:
undetectable
3ib1A-4dguA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fim LACTOTRANSFERRIN

(Bos taurus)
PF00405
(Transferrin)
4 PRO A 429
THR A 430
GLY A 662
THR A 663
None
None
CEL  A 711 (-3.3A)
None
0.44A 3ib1A-4fimA:
56.6
3ib1A-4fimA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iri TRANSCRIPTIONAL
REGULATOR ERG


(Homo sapiens)
PF00178
(Ets)
4 PRO A 327
THR A 325
GLY A 317
THR A 318
None
1.13A 3ib1A-4iriA:
undetectable
3ib1A-4iriA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
4 PRO A 457
THR A 455
GLY A 406
THR A 405
None
0.97A 3ib1A-4iugA:
undetectable
3ib1A-4iugA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
4 PRO A 831
THR A 751
GLY A 550
THR A 546
None
0.98A 3ib1A-4jx6A:
undetectable
3ib1A-4jx6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1


(Physcomitrella
patens)
PF01156
(IU_nuc_hydro)
4 PRO A 302
THR A 303
GLY A 276
THR A 275
None
1.02A 3ib1A-4kpnA:
1.1
3ib1A-4kpnA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE


(Haemophilus
influenzae)
PF01380
(SIS)
4 PRO A 151
THR A 150
GLY A 197
THR A 196
None
1.12A 3ib1A-4m0dA:
undetectable
3ib1A-4m0dA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE


(Yersinia
enterocolitica)
PF01380
(SIS)
4 PRO A 145
THR A 144
GLY A 191
THR A 190
None
SO4  A 301 (-3.0A)
None
None
1.08A 3ib1A-4s12A:
undetectable
3ib1A-4s12A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE


(Escherichia
coli)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 PRO A 240
THR A 242
GLY A 170
THR A 171
None
1.00A 3ib1A-4uekA:
undetectable
3ib1A-4uekA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unu IG LAMBDA CHAIN V-II
REGION MGC


(Homo sapiens)
PF07686
(V-set)
4 PRO A   8
THR A 105
GLY A  24
THR A  25
None
1.18A 3ib1A-4unuA:
undetectable
3ib1A-4unuA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
4 PRO A  98
THR A  97
GLY A  24
THR A  25
None
NAD  A 501 (-3.2A)
None
None
1.02A 3ib1A-4xr9A:
undetectable
3ib1A-4xr9A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
4 PRO A 109
THR A 111
GLY A 174
THR A 173
None
1.18A 3ib1A-4xwtA:
undetectable
3ib1A-4xwtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztp LIGHT CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53


(Oryctolagus
cuniculus)
PF07654
(C1-set)
PF07686
(V-set)
4 PRO L   2
THR L  97
GLY L 101
THR L 102
None
1.10A 3ib1A-4ztpL:
undetectable
3ib1A-4ztpL:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abj VP2

(Enterovirus A)
PF00073
(Rhv)
4 PRO B  53
THR B  54
GLY B  93
THR B  87
None
1.03A 3ib1A-5abjB:
undetectable
3ib1A-5abjB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE


(Methanospirillum
hungatei)
PF00485
(PRK)
4 PRO A 113
THR A 114
GLY A  21
THR A 137
None
1.16A 3ib1A-5b3fA:
undetectable
3ib1A-5b3fA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8c VP0

(Enterovirus A)
PF00073
(Rhv)
PF02226
(Pico_P1A)
4 PRO B 122
THR B 123
GLY B 162
THR B 156
None
1.02A 3ib1A-5c8cB:
undetectable
3ib1A-5c8cB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7l MAV36 TCR ALPHA
CHAIN


(Homo sapiens)
PF07686
(V-set)
PF09291
(DUF1968)
4 PRO D  43
THR D  44
GLY D  82
THR D  81
None
1.10A 3ib1A-5d7lD:
undetectable
3ib1A-5d7lD:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnm D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE


(Enterococcus
faecalis)
PF02557
(VanY)
4 PRO A 183
THR A 185
GLY A 234
THR A 230
None
1.05A 3ib1A-5hnmA:
undetectable
3ib1A-5hnmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES


(Corynebacterium
glutamicum)
PF00933
(Glyco_hydro_3)
4 PRO A 112
THR A 110
GLY A 173
THR A 172
None
1.02A 3ib1A-5iobA:
undetectable
3ib1A-5iobA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvt FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR


(Homo sapiens)
PF00178
(Ets)
4 PRO A 314
THR A 312
GLY A 304
THR A 305
None
1.16A 3ib1A-5jvtA:
undetectable
3ib1A-5jvtA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE


(Shewanella
oneidensis)
PF01041
(DegT_DnrJ_EryC1)
4 PRO A   2
THR A 187
GLY A  61
THR A  62
None
None
PDG  A 501 (-3.4A)
PDG  A 501 (-3.7A)
1.12A 3ib1A-5k8bA:
0.7
3ib1A-5k8bA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE


(Bradyrhizobium
sp.)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 PRO A 360
THR A 361
GLY A 268
THR A 269
None
0.93A 3ib1A-5k8oA:
undetectable
3ib1A-5k8oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2k BRIAKINUMAB FAB
LIGHT CHAIN


(Homo sapiens)
no annotation 4 PRO G 169
THR G 168
GLY G  42
THR G  43
None
1.05A 3ib1A-5n2kG:
undetectable
3ib1A-5n2kG:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B


(Cynara
cardunculus)
no annotation 4 PRO A  89
THR A 153
GLY A 127
THR A 126
None
1.05A 3ib1A-5nfgA:
undetectable
3ib1A-5nfgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE


(Homo sapiens)
no annotation 4 PRO A 285
THR A 286
GLY A 549
THR A 551
None
1.01A 3ib1A-5nn8A:
undetectable
3ib1A-5nn8A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G


(Methanothermococcus
thermolithotrophicus)
PF01058
(Oxidored_q6)
4 PRO E  39
THR E   6
GLY E  83
THR E  84
None
None
SF4  E 302 ( 4.2A)
SF4  E 302 (-4.6A)
1.07A 3ib1A-5odrE:
undetectable
3ib1A-5odrE:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2


(Leishmania
infantum)
no annotation 4 PRO A 102
THR A 103
GLY A 216
THR A 217
None
1.09A 3ib1A-5ol0A:
undetectable
3ib1A-5ol0A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4z ANTIBODY DH501 FAB
LIGHT CHAIN


(Macaca mulatta)
no annotation 4 PRO L   9
THR L 102
GLY L  25
THR L  26
None
1.14A 3ib1A-5t4zL:
undetectable
3ib1A-5t4zL:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz8 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus)
PF00535
(Glycos_transf_2)
4 PRO A 474
THR A 473
GLY A 510
THR A 509
None
0.93A 3ib1A-5tz8A:
undetectable
3ib1A-5tz8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u02 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus)
no annotation 4 PRO A 474
THR A 473
GLY A 510
THR A 509
None
IMD  A 601 (-3.8A)
None
None
0.94A 3ib1A-5u02A:
undetectable
3ib1A-5u02A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR


(Homo sapiens)
no annotation 4 PRO A 236
THR A 238
GLY A 228
THR A 216
None
1.14A 3ib1A-5u8qA:
undetectable
3ib1A-5u8qA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6s ACETYLXYLAN ESTERASE
A


(Aspergillus
awamori)
PF10503
(Esterase_phd)
4 PRO A 262
THR A 260
GLY A  42
THR A  43
None
1.18A 3ib1A-5x6sA:
undetectable
3ib1A-5x6sA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0n ENVELOPE
GLYCOPROTEIN GP140


(Human
immunodeficiency
virus 1)
no annotation 4 PRO G 470
THR G 455
GLY G 459
THR G 461
None
1.08A 3ib1A-6b0nG:
undetectable
3ib1A-6b0nG:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM


(Saccharomyces
cerevisiae)
no annotation 4 PRO A 816
THR A 379
GLY A 408
THR A 411
None
1.18A 3ib1A-6c6lA:
undetectable
3ib1A-6c6lA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Methanothermococcus
thermolithotrophicus)
no annotation 4 PRO I  90
THR I  91
GLY I 117
THR I 118
None
1.08A 3ib1A-6esqI:
undetectable
3ib1A-6esqI:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-)
no annotation 4 PRO A 443
THR A 441
GLY A 280
THR A 279
None
1.14A 3ib1A-6gnfA:
undetectable
3ib1A-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-)
no annotation 4 PRO D 353
THR D 329
GLY D 324
THR D 323
None
1.16A 3ib1A-6gsaD:
undetectable
3ib1A-6gsaD:
undetectable