SIMILAR PATTERNS OF AMINO ACIDS FOR 3IAZ_A_AINA1202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3i PROTEIN
(PLASTOCYANIN)

(Prochlorothrix
hollandica) 		PF00127
(Copper-bind) 		3 GLU A  97
GLY A  76
THR A  77
 None
 0.30A 3iazA-1b3iA:
0.0		 3iazA-1b3iA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g25 CDK-ACTIVATING
KINASE ASSEMBLY
FACTOR MAT1

(Homo sapiens) 		PF17121
(zf-C3HC4_5) 		3 GLU A  48
GLY A  50
THR A  51
 None
None
ZN  A  67 ( 4.5A)
 0.49A 3iazA-1g25A:
undetectable		 3iazA-1g25A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g82 FIBROBLAST GROWTH
FACTOR 9

(Homo sapiens) 		PF00167
(FGF) 		3 GLU A 123
GLY A 175
THR A 176
 None
 0.58A 3iazA-1g82A:
undetectable		 3iazA-1g82A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkp HYDANTOINASE

(Thermus sp.) 		PF01979
(Amidohydro_1) 		3 GLU A 185
GLY A 220
THR A 221
 None
 0.48A 3iazA-1gkpA:
0.0		 3iazA-1gkpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))

(Homo sapiens) 		PF01336
(tRNA_anti-codon)
PF16900
(REPA_OB_2) 		3 GLU A 283
GLY A 260
THR A 261
 None
 0.42A 3iazA-1jmcA:
0.0		 3iazA-1jmcA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 GLU A  43
GLY A   6
THR A   7
 None
 0.47A 3iazA-1lpjA:
0.0		 3iazA-1lpjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		3 GLU B 163
GLY B 233
THR B 232
 None
 0.56A 3iazA-1mioB:
0.2		 3iazA-1mioB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		3 GLU A  41
GLY A   4
THR A   5
 None
 0.51A 3iazA-1p6pA:
undetectable		 3iazA-1p6pA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcs PLASTOCYANIN

(Synechocystis
sp. PCC 6803) 		PF00127
(Copper-bind) 		3 GLU A  99
GLY A  78
THR A  79
 None
 0.57A 3iazA-1pcsA:
undetectable		 3iazA-1pcsA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6v PHOSPHOLIPASE A2
VRV-PL-VIIIA

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		3 GLU A 129
GLY A  35
THR A  36
 None
 0.45A 3iazA-1q6vA:
undetectable		 3iazA-1q6vA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A 227
GLY A 230
THR A 231
 None
 0.48A 3iazA-1ua2A:
undetectable		 3iazA-1ua2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)

(Homo sapiens) 		PF00595
(PDZ) 		3 GLU A  31
GLY A  29
THR A  71
 None
 0.52A 3iazA-1uepA:
undetectable		 3iazA-1uepA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3y PEPTIDE DEFORMYLASE

(Thermus
thermophilus) 		PF01327
(Pep_deformylase) 		3 GLU A 112
GLY A  98
THR A  99
 None
 0.49A 3iazA-1v3yA:
undetectable		 3iazA-1v3yA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8h SULFUR OXIDATION
PROTEIN SOXZ

(Thermus
thermophilus) 		PF08770
(SoxZ) 		3 GLU A 106
GLY A  85
THR A  86
 None
 0.54A 3iazA-1v8hA:
undetectable		 3iazA-1v8hA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi9 PUTATIVE
TRANSAMINASE

(Pyrococcus
furiosus) 		PF00155
(Aminotran_1_2) 		3 GLU A  12
GLY A 132
THR A 131
 None
 0.50A 3iazA-1xi9A:
undetectable		 3iazA-1xi9A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpp DNA-DIRECTED RNA
POLYMERASE SUBUNIT L

(Thermoplasma
acidophilum) 		PF13656
(RNA_pol_L_2) 		3 GLU A  88
GLY A  91
THR A  92
 None
 0.57A 3iazA-1xppA:
undetectable		 3iazA-1xppA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1f URIDYLATE KINASE

(Haemophilus
influenzae) 		PF00696
(AA_kinase) 		3 GLU A 232
GLY A 229
THR A 228
 None
 0.41A 3iazA-2a1fA:
undetectable		 3iazA-2a1fA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 GLU A 221
GLY A 154
THR A 155
 None
 0.58A 3iazA-2cx9A:
undetectable		 3iazA-2cx9A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		3 GLU A  49
GLY A  51
THR A  52
 None
 0.46A 3iazA-2e4uA:
1.5		 3iazA-2e4uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		3 GLU X 369
GLY X 436
THR X 437
 None
 0.53A 3iazA-2f2lX:
undetectable		 3iazA-2f2lX:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase) 		3 GLU A 267
GLY A 299
THR A 298
 None
 0.54A 3iazA-2hc8A:
undetectable		 3iazA-2hc8A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLU A 346
GLY A 349
THR A 348
 None
 0.56A 3iazA-2ji9A:
0.0		 3iazA-2ji9A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2juh TELOMERE BINDING
PROTEIN TBP1

(Nicotiana
glutinosa) 		PF00249
(Myb_DNA-binding) 		3 GLU A 593
GLY A 596
THR A 597
 None
 0.57A 3iazA-2juhA:
undetectable		 3iazA-2juhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kny LRP-1, LINKER, APO-E

(Homo sapiens) 		PF00057
(Ldl_recept_a) 		3 GLU A 131
GLY A  51
THR A  50
 None
 0.56A 3iazA-2knyA:
undetectable		 3iazA-2knyA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lc5 CALMODULIN, PUTATIVE

(Entamoeba
histolytica) 		PF13499
(EF-hand_7) 		3 GLU A  34
GLY A  37
THR A  38
 None
 0.59A 3iazA-2lc5A:
undetectable		 3iazA-2lc5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m0o PHD FINGER PROTEIN 1

(Homo sapiens) 		no annotation 3 GLU A  66
GLY A  49
THR A  50
 None
 0.56A 3iazA-2m0oA:
undetectable		 3iazA-2m0oA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		3 GLU A 162
GLY A 194
THR A 195
 None
 0.53A 3iazA-2m9pA:
undetectable		 3iazA-2m9pA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		3 GLU A 325
GLY A 307
THR A 306
 None
 0.52A 3iazA-2o4vA:
undetectable		 3iazA-2o4vA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		3 GLU A 830
GLY A 858
THR A 857
 None
 0.57A 3iazA-2r6fA:
undetectable		 3iazA-2r6fA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 GLU A 250
GLY A 242
THR A 243
 None
 0.58A 3iazA-2v9qA:
undetectable		 3iazA-2v9qA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		3 GLU A 247
GLY A 249
THR A 250
 None
 0.59A 3iazA-2w38A:
undetectable		 3iazA-2w38A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG

(Escherichia
coli) 		PF13483
(Lactamase_B_3) 		3 GLU A  53
GLY A  55
THR A  56
 None
 0.59A 3iazA-2wymA:
undetectable		 3iazA-2wymA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 GLU A 362
GLY A 365
THR A 364
 None
 0.57A 3iazA-2x3kA:
undetectable		 3iazA-2x3kA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz4 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		3 GLU A  92
GLY A 159
THR A 160
 None
 0.58A 3iazA-2xz4A:
undetectable		 3iazA-2xz4A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6b BASEPLATE STRUCTURAL
PROTEIN GP27

(Escherichia
virus T4) 		PF09096
(Phage-tail_2)
PF09097
(Phage-tail_1) 		3 GLU D  49
GLY D 110
THR D 111
 None
 0.53A 3iazA-2z6bD:
undetectable		 3iazA-2z6bD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoo PROBABLE NITRITE
REDUCTASE

(Pseudoalteromonas
haloplanktis) 		PF00034
(Cytochrom_C)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 GLU A 296
GLY A 272
THR A 273
 None
 0.48A 3iazA-2zooA:
undetectable		 3iazA-2zooA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a64 CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		3 GLU A 362
GLY A 335
THR A 336
 None
 0.59A 3iazA-3a64A:
undetectable		 3iazA-3a64A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE

(Sphingomonas
paucimobilis) 		PF13577
(SnoaL_4) 		3 GLU A  45
GLY A  48
THR A  49
 None
 0.48A 3iazA-3a76A:
undetectable		 3iazA-3a76A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		3 GLU A 344
GLY A 347
THR A 346
 None
 0.55A 3iazA-3c49A:
undetectable		 3iazA-3c49A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		3 GLU A 346
GLY A 350
THR A 349
 None
 0.59A 3iazA-3c4qA:
undetectable		 3iazA-3c4qA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esu ANTIBODY 14B7* LIGHT
CHAIN AND ANTIBODY
14B7* HEAVY CHAIN
LINKED WITH A
SYNTHETIC (GGGGS)4
LINKER

(Mus musculus) 		PF07686
(V-set) 		3 GLU F 105
GLY F  84
THR F  85
 None
 0.56A 3iazA-3esuF:
undetectable		 3iazA-3esuF:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhk UPF0403 PROTEIN YPHP

(Bacillus
subtilis) 		PF06491
(Disulph_isomer) 		3 GLU A  19
GLY A  22
THR A  21
 None
 0.57A 3iazA-3fhkA:
undetectable		 3iazA-3fhkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flu DIHYDRODIPICOLINATE
SYNTHASE

(Neisseria
meningitidis) 		PF00701
(DHDPS) 		3 GLU A  33
GLY A  35
THR A  36
 None
 0.56A 3iazA-3fluA:
undetectable		 3iazA-3fluA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A 237
GLY A 240
THR A 241
 None
 0.46A 3iazA-3gp0A:
undetectable		 3iazA-3gp0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grk ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		3 GLU A 103
GLY A 106
THR A 105
 None
 0.58A 3iazA-3grkA:
undetectable		 3iazA-3grkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		3 GLU A 365
GLY A 317
THR A 316
 None
VAK  A 537 (-3.0A)
VAK  A 537 (-4.2A)
 0.57A 3iazA-3ihgA:
undetectable		 3iazA-3ihgA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j08 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		3 GLU A 267
GLY A 299
THR A 298
 None
 0.53A 3iazA-3j08A:
undetectable		 3iazA-3j08A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 GLU A  58
GLY A  61
THR A  60
 None
 0.55A 3iazA-3j2iA:
undetectable		 3iazA-3j2iA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		3 GLU A 461
GLY A 463
THR A 464
 None
 0.56A 3iazA-3javA:
undetectable		 3iazA-3javA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		3 GLU A 129
GLY A 131
THR A 132
 MES  A 361 (-3.4A)
None
PG4  A 364 (-4.5A)
 0.55A 3iazA-3l6aA:
undetectable		 3iazA-3l6aA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		3 GLU A 302
GLY A 305
THR A 304
 None
 0.56A 3iazA-3lggA:
undetectable		 3iazA-3lggA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5c LINA

(uncultured
organism) 		no annotation 3 GLU B  45
GLY B  48
THR B  49
 None
 0.50A 3iazA-3s5cB:
undetectable		 3iazA-3s5cB:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 GLU A 183
GLY A 133
THR A 132
 None
 0.55A 3iazA-3sxfA:
undetectable		 3iazA-3sxfA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		3 GLU A 197
GLY A 201
THR A 200
 None
 0.51A 3iazA-3t5tA:
undetectable		 3iazA-3t5tA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLU A 151
GLY A 153
THR A 154
 None
 0.49A 3iazA-3t9wA:
undetectable		 3iazA-3t9wA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		3 GLU A 550
GLY A 554
THR A 553
 None
 0.42A 3iazA-3tlmA:
undetectable		 3iazA-3tlmA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uz0 STAGE III
SPORULATION PROTEIN
AH

(Bacillus
subtilis) 		PF12685
(SpoIIIAH) 		3 GLU A 150
GLY A 153
THR A 154
 None
 0.55A 3iazA-3uz0A:
undetectable		 3iazA-3uz0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		3 GLU A 232
GLY A 259
THR A 260
 None
 0.56A 3iazA-3wc3A:
undetectable		 3iazA-3wc3A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtc PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00106
(adh_short) 		3 GLU A 130
GLY A 132
THR A 133
 None
 0.54A 3iazA-3wtcA:
undetectable		 3iazA-3wtcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA

(Dictyostelium
discoideum) 		PF01267
(F-actin_cap_A) 		3 GLU A  78
GLY A  99
THR A  98
 None
 0.57A 3iazA-4akrA:
undetectable		 3iazA-4akrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azc BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		3 GLU A 921
GLY A 924
THR A 923
 None
 0.52A 3iazA-4azcA:
undetectable		 3iazA-4azcA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bub UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--LD-LYSINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 GLU A 325
GLY A 323
THR A 322
 None
 0.48A 3iazA-4bubA:
undetectable		 3iazA-4bubA:
21.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		3 GLU A 659
GLY A 662
THR A 663
 ZN  A 703 ( 1.9A)
CEL  A 711 (-3.3A)
None
 0.22A 3iazA-4fimA:
58.5		 3iazA-4fimA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz7 DIHYDROPYRIMIDINASE

(Tetraodon
nigroviridis) 		PF01979
(Amidohydro_1) 		3 GLU A 349
GLY A  90
THR A  91
 None
 0.58A 3iazA-4gz7A:
undetectable		 3iazA-4gz7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krr WNT INHIBITOR OF
DORSAL PROTEIN

(Drosophila
melanogaster) 		PF00110
(wnt) 		3 GLU A  37
GLY A  41
THR A  40
 None
 0.59A 3iazA-4krrA:
undetectable		 3iazA-4krrA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		3 GLU A 303
GLY A 278
THR A 279
 None
 0.56A 3iazA-4l4xA:
undetectable		 3iazA-4l4xA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lda TADZ

(Pseudomonas
aeruginosa) 		PF16968
(TadZ_N) 		3 GLU A 111
GLY A 114
THR A 113
 None
 0.55A 3iazA-4ldaA:
1.8		 3iazA-4ldaA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 3 GLU A 586
GLY A 589
THR A 590
 None
 0.55A 3iazA-4n5cA:
undetectable		 3iazA-4n5cA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		3 GLU A 209
GLY A 212
THR A 211
 None
 0.57A 3iazA-4nrhA:
undetectable		 3iazA-4nrhA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o65 PUTATIVE ARCHAEAL
AMMONIA
MONOOXYGENASE
SUBUNIT B

(Candidatus
Nitrosocaldus
yellowstonensis) 		PF04744
(Monooxygenase_B) 		3 GLU A 179
GLY A 153
THR A 154
 None
 0.45A 3iazA-4o65A:
undetectable		 3iazA-4o65A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		3 GLU A 209
GLY A 212
THR A 211
 None
 0.57A 3iazA-4p3zA:
undetectable		 3iazA-4p3zA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0h T-BOX TRANSCRIPTION
FACTOR TBX5

(Homo sapiens) 		PF00907
(T-box) 		3 GLU A  69
GLY A  71
THR A  72
 None
 0.59A 3iazA-4s0hA:
undetectable		 3iazA-4s0hA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		3 GLU C 559
GLY C 562
THR C 561
 None
 0.51A 3iazA-4yfaC:
undetectable		 3iazA-4yfaC:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis) 		no annotation 3 GLU A 613
GLY A 615
THR A 616
 None
 0.53A 3iazA-4z38A:
undetectable		 3iazA-4z38A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		3 GLU A 188
GLY A 191
THR A 190
 None
 0.58A 3iazA-4zxoA:
undetectable		 3iazA-4zxoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		3 GLU A 522
GLY A 526
THR A 525
 None
 0.46A 3iazA-5a2oA:
undetectable		 3iazA-5a2oA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		3 GLU A 761
GLY A 764
THR A 763
 None
 0.53A 3iazA-5c9iA:
undetectable		 3iazA-5c9iA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		3 GLU A 185
GLY A 188
THR A 187
 None
 0.55A 3iazA-5d39A:
undetectable		 3iazA-5d39A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca) 		PF01497
(Peripla_BP_2) 		3 GLU A 101
GLY A 103
THR A 104
 None
 0.53A 3iazA-5dh2A:
undetectable		 3iazA-5dh2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 GLU A 395
GLY A 398
THR A 399
 None
 0.54A 3iazA-5dkxA:
undetectable		 3iazA-5dkxA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6t CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		3 GLU A 394
GLY A 271
THR A 272
 None
 0.58A 3iazA-5e6tA:
undetectable		 3iazA-5e6tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec0 ALP7A

(Bacillus
subtilis) 		no annotation 3 GLU A 173
GLY A 153
THR A 154
 None
 0.54A 3iazA-5ec0A:
undetectable		 3iazA-5ec0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eix DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A

(Klebsiella
pneumoniae) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 GLU A 544
GLY A 547
THR A 546
 None
 0.57A 3iazA-5eixA:
1.9		 3iazA-5eixA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fre EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF02973
(Sialidase) 		3 GLU A 174
GLY A  33
THR A  34
 None
 0.56A 3iazA-5freA:
undetectable		 3iazA-5freA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 3 GLU A 272
GLY A 294
THR A 295
 CA  A1350 (-3.4A)
None
None
 0.56A 3iazA-5fzpA:
undetectable		 3iazA-5fzpA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED

(Oryza sativa) 		PF03514
(GRAS) 		3 GLU A 306
GLY A 309
THR A 308
 None
 0.56A 3iazA-5hyzA:
undetectable		 3iazA-5hyzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i01 PHOSPHOHEPTOSE
ISOMERASE

(Neisseria
gonorrhoeae) 		PF13580
(SIS_2) 		3 GLU A  65
GLY A  68
THR A  67
 ZN  A 301 (-2.4A)
None
None
 0.50A 3iazA-5i01A:
undetectable		 3iazA-5i01A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 GLU A 674
GLY A 715
THR A 714
 PG4  A2005 (-3.8A)
None
None
 0.56A 3iazA-5kf7A:
undetectable		 3iazA-5kf7A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 3 GLU B 363
GLY B 379
THR B 378
 None
 0.57A 3iazA-5kisB:
undetectable		 3iazA-5kisB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 GLU W 299
GLY W 301
THR W 302
 None
 0.53A 3iazA-5o9gW:
undetectable		 3iazA-5o9gW:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ore OCTOPINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 3 GLU A 257
GLY A 259
THR A 260
 None
 0.55A 3iazA-5oreA:
5.1		 3iazA-5oreA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1

(Streptomyces
coelicolor) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 GLU A 205
GLY A  98
THR A  99
 None
 0.59A 3iazA-5vsjA:
undetectable		 3iazA-5vsjA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x33 LTB4
RECEPTOR,LYSOZYME,LT
B4 RECEPTOR

(Cavia
porcellus;
Escherichia
virus T4) 		no annotation 3 GLU A 187
GLY A 191
THR A 190
 None
 0.55A 3iazA-5x33A:
undetectable		 3iazA-5x33A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3e KINESIN-LIKE PROTEIN

(Caenorhabditis
elegans) 		PF00225
(Kinesin) 		3 GLU A 128
GLY A 130
THR A 131
 None
 0.56A 3iazA-5x3eA:
undetectable		 3iazA-5x3eA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 3 GLU A  39
GLY A  42
THR A  43
 None
 0.50A 3iazA-5x7nA:
undetectable		 3iazA-5x7nA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z1g RIBOSOME BIOGENESIS
PROTEIN BRX1

(Saccharomyces
cerevisiae) 		no annotation 3 GLU B 214
GLY B 127
THR B 126
 None
 0.53A 3iazA-5z1gB:
undetectable		 3iazA-5z1gB:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-8

(Homo sapiens) 		no annotation 3 GLU C 116
GLY C 118
THR C 119
 None
 0.59A 3iazA-6avoC:
undetectable		 3iazA-6avoC:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 3 GLU A 411
GLY A 418
THR A 419
 None
 0.46A 3iazA-6ceyA:
undetectable		 3iazA-6ceyA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f6s ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 3 GLU A 229
GLY A 224
THR A 223
 NAG  A 502 ( 4.3A)
None
None
 0.40A 3iazA-6f6sA:
undetectable		 3iazA-6f6sA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 3 GLU A1207
GLY A1210
THR A1211
 None
 0.55A 3iazA-6fikA:
undetectable		 3iazA-6fikA:
14.24