SIMILAR PATTERNS OF AMINO ACIDS FOR 3IA4_B_MTXB164_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1de3 | RIBONUCLEASEALPHA-SARCIN (Aspergillusgiganteus) |
no annotation | 4 | PHE A 71LYS A 70ILE A 135THR A 125 | None | 1.31A | 3ia4B-1de3A:undetectable | 3ia4B-1de3A:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fiz | BETA-ACROSIN HEAVYCHAIN (Sus scrofa) |
PF00089(Trypsin) | 4 | PHE A 59LYS A 61ILE A 106THR A 41 | None | 1.50A | 3ia4B-1fizA:undetectable | 3ia4B-1fizA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hjo | PROTEIN (HEAT-SHOCK70KD PROTEIN) (Homo sapiens) |
PF00012(HSP70) | 4 | PHE A 245LYS A 246ILE A 291THR A 295 | None | 0.72A | 3ia4B-1hjoA:undetectable | 3ia4B-1hjoA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ku1 | ARFGUANINE-NUCLEOTIDEEXCHANGE FACTOR 2 (Saccharomycescerevisiae) |
PF01369(Sec7) | 4 | PHE A 649LYS A 648ILE A 661THR A 610 | None | 1.38A | 3ia4B-1ku1A:undetectable | 3ia4B-1ku1A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o1c | SKELETAL MUSCLEMYOSIN II REGULATORYLIGHT CHAIN (Gallus gallus) |
PF13833(EF-hand_8) | 4 | PHE B 31LYS B 28ILE B 42THR B 82 | None | 1.44A | 3ia4B-1o1cB:undetectable | 3ia4B-1o1cB:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ocm | MALONAMIDASE E2 (Bradyrhizobiumjaponicum) |
PF01425(Amidase) | 4 | PHE A 39LYS A 104ILE A 29THR A 118 | None | 1.47A | 3ia4B-1ocmA:undetectable | 3ia4B-1ocmA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odf | HYPOTHETICAL 33.3KDA PROTEIN INADE3-SER2 INTERGENICREGION (Saccharomycescerevisiae) |
no annotation | 4 | PHE A 36LYS A 44ILE A 51THR A 270 | NoneSO4 A 501 (-3.5A)NoneNone | 1.44A | 3ia4B-1odfA:1.7 | 3ia4B-1odfA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9d | UV EXCISION REPAIRPROTEIN RAD23HOMOLOG A (Homo sapiens) |
PF00240(ubiquitin) | 4 | PHE U 15LYS U 8ILE U 32THR U 4 | None | 1.39A | 3ia4B-1p9dU:undetectable | 3ia4B-1p9dU:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1re0 | ARFGUANINE-NUCLEOTIDEEXCHANGE FACTOR 1 (Saccharomycescerevisiae) |
PF01369(Sec7) | 4 | PHE B 192LYS B 191ILE B 204THR B 153 | None | 1.28A | 3ia4B-1re0B:undetectable | 3ia4B-1re0B:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wlt | 176AA LONGHYPOTHETICALDTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE (Sulfurisphaeratokodaii) |
PF00908(dTDP_sugar_isom) | 4 | PHE A 36LYS A 32ILE A 15THR A 133 | None | 1.45A | 3ia4B-1wltA:undetectable | 3ia4B-1wltA:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x1f | SIGNAL-TRANSDUCINGADAPTOR PROTEIN 1 (Homo sapiens) |
PF00169(PH) | 4 | PHE A 48LYS A 60ILE A 26THR A 50 | None | 1.35A | 3ia4B-1x1fA:undetectable | 3ia4B-1x1fA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y88 | HYPOTHETICAL PROTEINAF1548 (Archaeoglobusfulgidus) |
PF04471(Mrr_cat) | 4 | PHE A 54LYS A 3ILE A 118THR A 61 | None | 1.37A | 3ia4B-1y88A:undetectable | 3ia4B-1y88A:18.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zdr | DIHYDROFOLATEREDUCTASE (Geobacillusstearothermophilus) |
PF00186(DHFR_1) | 4 | PHE A 31LYS A 32ILE A 96THR A 115 | SO4 A3486 (-4.1A)SO4 A3484 (-3.1A)NoneNone | 0.39A | 3ia4B-1zdrA:25.0 | 3ia4B-1zdrA:46.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cz2 | MALEYLACETOACETATEISOMERASE (Mus musculus) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | PHE A 50LYS A 57ILE A 36THR A 68 | None | 1.43A | 3ia4B-2cz2A:undetectable | 3ia4B-2cz2A:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gj2 | WSV230 (White spotsyndrome virus) |
PF09625(VP9) | 4 | PHE A 4LYS A 2ILE A 73THR A 52 | None | 1.25A | 3ia4B-2gj2A:undetectable | 3ia4B-2gj2A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kcm | COLD SHOCK DOMAINFAMILY PROTEIN (Shewanellaoneidensis) |
PF00313(CSD) | 4 | PHE A 49LYS A 2ILE A 17THR A 52 | None | 1.46A | 3ia4B-2kcmA:undetectable | 3ia4B-2kcmA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3l | HYPOTHETICAL PROTEIN (Bacillus cereus) |
PF06304(DUF1048) | 4 | PHE A 33LYS A 34ILE A 59THR A 76 | None | 1.49A | 3ia4B-2o3lA:undetectable | 3ia4B-2o3lA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7z | HEAT SHOCK COGNATE71 KDA PROTEIN (Rattusnorvegicus) |
PF00012(HSP70) | 4 | PHE A 245LYS A 246ILE A 291THR A 295 | None | 0.65A | 3ia4B-2v7zA:undetectable | 3ia4B-2v7zA:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xio | PUTATIVEDEOXYRIBONUCLEASETATDN1 (Homo sapiens) |
PF01026(TatD_DNase) | 4 | PHE A 47LYS A 46ILE A 36THR A 221 | None | 1.28A | 3ia4B-2xioA:undetectable | 3ia4B-2xioA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xl4 | LMO0438 PROTEIN (Listeriamonocytogenes) |
no annotation | 4 | PHE A 137LYS A 138ILE A 67THR A 189 | None | 1.32A | 3ia4B-2xl4A:undetectable | 3ia4B-2xl4A:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aib | GLUCOSYLTRANSFERASE-SI (Streptococcusmutans) |
PF02324(Glyco_hydro_70) | 4 | PHE A 885LYS A 884ILE A 878THR A 891 | None | 1.29A | 3ia4B-3aibA:undetectable | 3ia4B-3aibA:11.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gb0 | PEPTIDASE T (Bacillus cereus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | PHE A 11LYS A 109ILE A 96THR A 359 | None | 1.45A | 3ia4B-3gb0A:undetectable | 3ia4B-3gb0A:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hij | DIHYDRODIPICOLINATESYNTHASE (Bacillusanthracis) |
PF00701(DHDPS) | 4 | PHE A 4LYS A 1ILE A 76THR A 6 | None | 1.39A | 3ia4B-3hijA:undetectable | 3ia4B-3hijA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfg | UNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF16729(DUF5067) | 4 | PHE A 69LYS A 68ILE A 64THR A 154 | None | 1.26A | 3ia4B-3qfgA:undetectable | 3ia4B-3qfgA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8k | UNCHARACTERIZEDPROTEIN (Leptotrichiabuccalis) |
no annotation | 4 | PHE A 116LYS A 117ILE A 136THR A 74 | None | 1.35A | 3ia4B-3t8kA:undetectable | 3ia4B-3t8kA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tdm | COMPUTATIONALLYDESIGNED TWO-FOLDSYMMETRIC TIM-BARRELPROTEIN, FLR (HALFMOLECULE) (syntheticconstruct) |
PF00977(His_biosynth) | 4 | PHE A 89LYS A 85ILE A 102THR A 119 | None | 1.31A | 3ia4B-3tdmA:undetectable | 3ia4B-3tdmA:22.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 4 | PHE A 32LYS A 33ILE A 96THR A 115 | MTX A2001 (-4.3A)NoneMTX A2001 ( 4.2A)MTX A2001 (-4.3A) | 0.22A | 3ia4B-3tq9A:26.1 | 3ia4B-3tq9A:43.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uai | H/ACARIBONUCLEOPROTEINCOMPLEX SUBUNIT 1 (Saccharomycescerevisiae) |
PF04410(Gar1) | 4 | PHE C 109LYS C 108ILE C 51THR C 73 | None | 1.46A | 3ia4B-3uaiC:undetectable | 3ia4B-3uaiC:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vco | DIHYDROFOLATEREDUCTASE (Schistosomamansoni) |
PF00186(DHFR_1) | 4 | PHE A 32LYS A 33ILE A 111THR A 133 | None | 0.82A | 3ia4B-3vcoA:18.4 | 3ia4B-3vcoA:27.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhi | GAMMA-BUTYROBETAINEDIOXYGENASE (Homo sapiens) |
PF02668(TauD)PF06155(DUF971) | 4 | PHE A 330LYS A 331ILE A 231THR A 124 | None | 1.35A | 3ia4B-4bhiA:undetectable | 3ia4B-4bhiA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gky | PROTEIN ERGIC-53 (Homo sapiens) |
PF03388(Lectin_leg-like) | 4 | PHE A 52LYS A 53ILE A 80THR A 95 | None | 1.42A | 3ia4B-4gkyA:undetectable | 3ia4B-4gkyA:21.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h96 | DIHYDROFOLATEREDUCTASE (Candidaalbicans) |
PF00186(DHFR_1) | 4 | PHE A 36LYS A 37ILE A 112THR A 133 | 14Q A 202 (-4.0A)None14Q A 202 ( 4.2A)14Q A 202 ( 4.6A) | 0.45A | 3ia4B-4h96A:18.1 | 3ia4B-4h96A:35.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hum | MULTIDRUG EFFLUXPROTEIN (Neisseriagonorrhoeae) |
PF01554(MatE) | 4 | PHE A 244LYS A 245ILE A 106THR A 96 | None | 1.28A | 3ia4B-4humA:undetectable | 3ia4B-4humA:15.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwi | HEAT SHOCK COGNATE71 KDA PROTEIN (Homo sapiens) |
PF00012(HSP70) | 4 | PHE A 245LYS A 246ILE A 291THR A 295 | None | 0.90A | 3ia4B-4hwiA:undetectable | 3ia4B-4hwiA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4id3 | DNA REPAIR PROTEINREV1 (Saccharomycescerevisiae) |
PF16589(BRCT_2) | 4 | PHE A 166LYS A 164ILE A 232THR A 206 | None | 1.49A | 3ia4B-4id3A:undetectable | 3ia4B-4id3A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j8f | HEAT SHOCK 70 KDAPROTEIN 1A/1B,HSC70-INTERACTINGPROTEIN (Homo sapiens;Rattusnorvegicus) |
PF00012(HSP70) | 4 | PHE A 245LYS A 246ILE A 291THR A 295 | None | 0.76A | 3ia4B-4j8fA:undetectable | 3ia4B-4j8fA:13.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p68 | DIHYDROFOLATEREDUCTASE (Escherichiacoli) |
PF00186(DHFR_1) | 4 | PHE A 31LYS A 32ILE A 94THR A 113 | MTX A 201 (-4.1A)MTX A 201 ( 3.9A)MTX A 201 ( 4.3A)MTX A 201 ( 4.5A) | 0.40A | 3ia4B-4p68A:28.0 | 3ia4B-4p68A:55.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u6u | COG5 (Kluyveromyceslactis) |
PF10392(COG5) | 4 | PHE B 329LYS B 330ILE B 266THR B 258 | None | 1.23A | 3ia4B-4u6uB:undetectable | 3ia4B-4u6uB:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uc7 | NUCLEOPROTEIN (Humanorthopneumovirus) |
PF03246(Pneumo_ncap) | 4 | PHE A 111LYS A 110ILE A 104THR A 121 | None | 1.44A | 3ia4B-4uc7A:undetectable | 3ia4B-4uc7A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uc7 | NUCLEOPROTEIN (Humanorthopneumovirus) |
PF03246(Pneumo_ncap) | 4 | PHE A 111LYS A 110ILE A 129THR A 121 | None | 1.06A | 3ia4B-4uc7A:undetectable | 3ia4B-4uc7A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmu | TRAF3-INTERACTINGPROTEIN 1 (Mus musculus) |
PF10243(MIP-T3) | 4 | PHE A 72LYS A 69ILE A 39THR A 54 | None | 1.48A | 3ia4B-5fmuA:undetectable | 3ia4B-5fmuA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lj5 | PROTEIN CWC16 (Saccharomycescerevisiae) |
PF04502(DUF572) | 4 | PHE D 64LYS D 63ILE D 58THR D 85 | None C V 58 ( 2.7A)NoneNone | 1.31A | 3ia4B-5lj5D:undetectable | 3ia4B-5lj5D:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5syd | AZURIN, CHIMERICCONSTRUCT (Pseudomonasaeruginosa) |
PF00127(Copper-bind) | 4 | PHE A 70LYS A 82ILE A 113THR A 44 | None | 1.47A | 3ia4B-5sydA:undetectable | 3ia4B-5sydA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5udb | CELL DIVISION CYCLEPROTEIN CDT1 (Saccharomycescerevisiae) |
PF16679(CDT1_C) | 4 | PHE 8 119LYS 8 120ILE 8 143THR 8 150 | None | 1.35A | 3ia4B-5udb8:undetectable | 3ia4B-5udb8:14.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vmm | IRON-REGULATED CELLWALL-ANCHOREDPROTEIN (Staphylococcusaureus) |
no annotation | 4 | PHE H 198LYS H 125ILE H 236THR H 240 | None | 1.48A | 3ia4B-5vmmH:undetectable | 3ia4B-5vmmH:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yg7 | RIBOSE1,5-BISPHOSPHATEISOMERASE (Pyrococcushorikoshii) |
no annotation | 4 | PHE A 241LYS A 240ILE A 307THR A 245 | NoneRI2 A 401 (-2.8A)NoneNone | 0.96A | 3ia4B-5yg7A:2.9 | 3ia4B-5yg7A:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cv0 | SPIKE GLYCOPROTEIN (Aviancoronavirus) |
no annotation | 4 | PHE A 190LYS A 191ILE A 196THR A 99 | None | 1.27A | 3ia4B-6cv0A:undetectable | 3ia4B-6cv0A:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cxm | DIHYDROFOLATEREDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 4 | PHE A 32LYS A 33ILE A 92THR A 111 | MMV A 202 (-3.7A)MMV A 202 ( 4.6A)MMV A 202 ( 4.2A)MMV A 202 (-4.4A) | 0.48A | 3ia4B-6cxmA:21.7 | 3ia4B-6cxmA:29.08 |