SIMILAR PATTERNS OF AMINO ACIDS FOR 3IA4_A_MTXA164_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a3g | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE (Escherichiacoli) |
PF01063(Aminotran_4) | 4 | ILE A 225PHE A 200ILE A 226THR A 281 | None | 1.12A | 3ia4A-1a3gA:undetectable | 3ia4A-1a3gA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bc5 | CHEMOTAXIS RECEPTORMETHYLTRANSFERASE (Salmonellaenterica) |
PF01739(CheR)PF03705(CheR_N) | 4 | ILE A 34PHE A 85ILE A 30THR A 90 | NoneNoneNoneSAH A 287 (-3.5A) | 1.16A | 3ia4A-1bc5A:undetectable | 3ia4A-1bc5A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cns | CHITINASE (Hordeum vulgare) |
PF00182(Glyco_hydro_19) | 4 | ILE A 198PHE A 157ILE A 197THR A 64 | None | 1.16A | 3ia4A-1cnsA:undetectable | 3ia4A-1cnsA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d1p | TYROSINE PHOSPHATASE (Saccharomycescerevisiae) |
PF01451(LMWPc) | 4 | ILE A 130PHE A 116ILE A 148THR A 128 | None | 1.07A | 3ia4A-1d1pA:undetectable | 3ia4A-1d1pA:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g5g | FUSION PROTEIN (Avianavulavirus 1) |
PF00523(Fusion_gly) | 4 | ILE A 285PHE A 221ILE A 61THR A 231 | None | 1.07A | 3ia4A-1g5gA:undetectable | 3ia4A-1g5gA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyu | ADAPTER-RELATEDPROTEIN COMPLEX 1GAMMA 1 SUBUNIT (Mus musculus) |
PF02883(Alpha_adaptinC2) | 4 | ILE A 782PHE A 719ILE A 735THR A 731 | None | 1.14A | 3ia4A-1gyuA:undetectable | 3ia4A-1gyuA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1imv | PIGMENTEPITHELIUM-DERIVEDFACTOR (Homo sapiens) |
PF00079(Serpin) | 4 | ILE A 331PHE A 124ILE A 326THR A 334 | None | 1.06A | 3ia4A-1imvA:undetectable | 3ia4A-1imvA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pgp | 6-PHOSPHOGLUCONATEDEHYDROGENASE (Ovis aries) |
PF00393(6PGD)PF03446(NAD_binding_2) | 4 | ILE A 232PHE A 219ILE A 197THR A 225 | None | 1.04A | 3ia4A-1pgpA:2.6 | 3ia4A-1pgpA:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1szq | 2-METHYLCITRATEDEHYDRATASE (Escherichiacoli) |
PF03972(MmgE_PrpD) | 4 | ILE A 354PHE A 358ILE A 376THR A 362 | None | 1.13A | 3ia4A-1szqA:undetectable | 3ia4A-1szqA:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uus | STAT PROTEIN (Dictyosteliumdiscoideum) |
PF00017(SH2)PF09267(Dict-STAT-coil) | 4 | ILE A 588PHE A 651ILE A 611THR A 581 | None | 1.12A | 3ia4A-1uusA:undetectable | 3ia4A-1uusA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wlt | 176AA LONGHYPOTHETICALDTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE (Sulfurisphaeratokodaii) |
PF00908(dTDP_sugar_isom) | 4 | ILE A 72PHE A 36ILE A 15THR A 133 | None | 1.12A | 3ia4A-1wltA:undetectable | 3ia4A-1wltA:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y3j | COPPER-TRANSPORTINGATPASE 1 (Homo sapiens) |
PF00403(HMA) | 4 | ILE A 61PHE A 66ILE A 21THR A 69 | None | 1.17A | 3ia4A-1y3jA:undetectable | 3ia4A-1y3jA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yub | RRNAMETHYLTRANSFERASE (Streptococcuspneumoniae) |
PF00398(RrnaAD) | 4 | ILE A 97PHE A 89ILE A 36THR A 32 | None | 1.04A | 3ia4A-1yubA:undetectable | 3ia4A-1yubA:20.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zdr | DIHYDROFOLATEREDUCTASE (Geobacillusstearothermophilus) |
PF00186(DHFR_1) | 4 | ILE A 5PHE A 31ILE A 96THR A 115 | NoneSO4 A3486 (-4.1A)NoneNone | 0.28A | 3ia4A-1zdrA:25.1 | 3ia4A-1zdrA:46.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a9v | GMP SYNTHASE (Thermoplasmaacidophilum) |
PF00117(GATase) | 4 | ILE A 161PHE A 90ILE A 69THR A 158 | None | 1.17A | 3ia4A-2a9vA:undetectable | 3ia4A-2a9vA:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b0t | NADP ISOCITRATEDEHYDROGENASE (Corynebacteriumglutamicum) |
PF03971(IDH) | 4 | ILE A 528PHE A 395ILE A 525THR A 399 | None | 0.88A | 3ia4A-2b0tA:undetectable | 3ia4A-2b0tA:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9u | HYPOTHETICALDTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE (Sulfurisphaeratokodaii) |
PF00908(dTDP_sugar_isom) | 4 | ILE A 72PHE A 36ILE A 15THR A 133 | None | 1.10A | 3ia4A-2b9uA:undetectable | 3ia4A-2b9uA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2blb | DIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumvivax) |
PF00186(DHFR_1) | 4 | ILE A 13PHE A 57ILE A 173THR A 194 | CP7 A1240 (-4.1A)CP7 A1240 ( 4.1A)CP7 A1240 ( 3.8A)CP7 A1240 (-4.1A) | 0.31A | 3ia4A-2blbA:20.3 | 3ia4A-2blbA:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ebw | DNA REPAIR PROTEINREV1 (Homo sapiens) |
PF16589(BRCT_2) | 4 | ILE A 54PHE A 49ILE A 114THR A 88 | None | 1.16A | 3ia4A-2ebwA:undetectable | 3ia4A-2ebwA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gu0 | NONSTRUCTURALPROTEIN 2 (Rotavirus C) |
PF02509(Rota_NS35) | 4 | ILE A 188PHE A 164ILE A 194THR A 149 | None | 0.96A | 3ia4A-2gu0A:undetectable | 3ia4A-2gu0A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i7g | MONOOXYGENASE (Agrobacteriumfabrum) |
PF00296(Bac_luciferase) | 4 | ILE A 233PHE A 304ILE A 200THR A 231 | None | 0.96A | 3ia4A-2i7gA:undetectable | 3ia4A-2i7gA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jam | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE 1G (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 278PHE A 254ILE A 125THR A 282 | None | 1.06A | 3ia4A-2jamA:undetectable | 3ia4A-2jamA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jc6 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE 1D (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 279PHE A 255ILE A 125THR A 283 | None | 1.07A | 3ia4A-2jc6A:undetectable | 3ia4A-2jc6A:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mbg | RALA-BINDING PROTEIN1 (Homo sapiens) |
PF00620(RhoGAP) | 4 | ILE A 322PHE A 360ILE A 318THR A 362 | None | 1.03A | 3ia4A-2mbgA:undetectable | 3ia4A-2mbgA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nq5 | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Streptococcusmutans) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 4 | ILE A 304PHE A 258ILE A 269THR A 297 | None | 1.05A | 3ia4A-2nq5A:undetectable | 3ia4A-2nq5A:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0a | POTASSIUM/SODIUMHYPERPOLARIZATION-ACTIVATED CYCLICNUCLEOTIDE-GATEDCHANNEL 2 (Mus musculus) |
PF00027(cNMP_binding) | 4 | ILE A 545PHE A 580ILE A 544THR A 592 | PCG A 401 ( 4.0A)NoneNonePCG A 401 (-2.9A) | 0.98A | 3ia4A-2q0aA:undetectable | 3ia4A-2q0aA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wn4 | ADP-RIBOSYLTRANSFERASE ENZYMATICCOMPONENT (Clostridioidesdifficile) |
PF03496(ADPrib_exo_Tox) | 4 | ILE A 194PHE A 107ILE A 192THR A 132 | None | 1.16A | 3ia4A-2wn4A:undetectable | 3ia4A-2wn4A:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zi8 | PROBABLEBIPHENYL-2,3-DIOL1,2-DIOXYGENASE BPHC (Mycobacteriumtuberculosis) |
PF00903(Glyoxalase) | 4 | ILE A 213PHE A 263ILE A 11THR A 209 | None | 1.14A | 3ia4A-2zi8A:undetectable | 3ia4A-2zi8A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ce1 | SUPEROXIDE DISMUTASE[CU-ZN] (Naganishialiquefaciens) |
PF00080(Sod_Cu) | 4 | ILE A 38PHE A 49ILE A 21THR A 93 | None | 1.16A | 3ia4A-3ce1A:undetectable | 3ia4A-3ce1A:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dpj | TRANSCRIPTIONREGULATOR, TETRFAMILY (Ruegeriapomeroyi) |
PF00440(TetR_N) | 4 | ILE A 10PHE A 42ILE A 31THR A 6 | None | 1.06A | 3ia4A-3dpjA:undetectable | 3ia4A-3dpjA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzc | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Vibrio cholerae) |
PF02350(Epimerase_2) | 4 | ILE A 366PHE A 147ILE A 369THR A 173 | None | 1.15A | 3ia4A-3dzcA:undetectable | 3ia4A-3dzcA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ei8 | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Arabidopsisthaliana) |
PF00155(Aminotran_1_2) | 4 | ILE A 70PHE A 274ILE A 74THR A 66 | None | 0.84A | 3ia4A-3ei8A:undetectable | 3ia4A-3ei8A:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f1x | SERINEACETYLTRANSFERASE (Bacteroidesvulgatus) |
PF00132(Hexapep) | 4 | ILE A 160PHE A 203ILE A 205THR A 132 | None | 0.95A | 3ia4A-3f1xA:undetectable | 3ia4A-3f1xA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fk4 | RUBISCO-LIKE PROTEIN (Bacillus cereus) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 4 | ILE A 92PHE A 85ILE A 4THR A 94 | None | 1.16A | 3ia4A-3fk4A:undetectable | 3ia4A-3fk4A:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn6 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Borreliellaburgdorferi) |
PF01182(Glucosamine_iso) | 4 | ILE A 131PHE A 69ILE A 36THR A 192 | None | 1.00A | 3ia4A-3hn6A:undetectable | 3ia4A-3hn6A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib5 | SEX PHEROMONEPRECURSOR (Lactobacillussalivarius) |
PF07537(CamS) | 4 | ILE A 353PHE A 331ILE A 318THR A 375 | None | 0.96A | 3ia4A-3ib5A:undetectable | 3ia4A-3ib5A:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kw0 | CYSTEINE PEPTIDASE (Bacillus cereus) |
PF05708(Peptidase_C92) | 4 | ILE A 39PHE A 178ILE A 139THR A 50 | None | 1.11A | 3ia4A-3kw0A:undetectable | 3ia4A-3kw0A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kw8 | PUTATIVE COPPEROXIDASE (Streptomycescoelicolor) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | ILE A 193PHE A 233ILE A 221THR A 225 | None | 1.02A | 3ia4A-3kw8A:undetectable | 3ia4A-3kw8A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogj | PRKG1 PROTEIN (Homo sapiens) |
PF00027(cNMP_binding) | 4 | ILE A 146PHE A 181ILE A 145THR A 193 | CMP A 250 ( 4.2A)NoneNoneCMP A 250 (-2.9A) | 1.04A | 3ia4A-3ogjA:undetectable | 3ia4A-3ogjA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oox | PUTATIVE 2OG-FE(II)OXYGENASE FAMILYPROTEIN (Caulobactervibrioides) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 4 | ILE A 230PHE A 29ILE A 196THR A 245 | None | 1.05A | 3ia4A-3ooxA:undetectable | 3ia4A-3ooxA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pxl | LACCASE (Trameteshirsuta) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | ILE A 171PHE A 211ILE A 146THR A 169 | None | 1.01A | 3ia4A-3pxlA:undetectable | 3ia4A-3pxlA:13.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rh2 | HYPOTHETICALTETR-LIKETRANSCRIPTIONALREGULATOR (Shewanellaamazonensis) |
PF00440(TetR_N)PF13972(TetR) | 4 | ILE A 7PHE A 43ILE A 8THR A 25 | None | 0.90A | 3ia4A-3rh2A:undetectable | 3ia4A-3rh2A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3shr | CGMP-DEPENDENTPROTEIN KINASE 1 (Bos taurus) |
PF00027(cNMP_binding) | 4 | ILE A 130PHE A 165ILE A 129THR A 177 | CMP A 401 (-4.1A)NoneNoneCMP A 401 (-2.8A) | 1.14A | 3ia4A-3shrA:undetectable | 3ia4A-3shrA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3shr | CGMP-DEPENDENTPROTEIN KINASE 1 (Bos taurus) |
PF00027(cNMP_binding) | 4 | ILE A 248PHE A 289ILE A 247THR A 301 | None | 0.73A | 3ia4A-3shrA:undetectable | 3ia4A-3shrA:18.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 4 | ILE A 6PHE A 32ILE A 96THR A 115 | MTX A2001 (-4.0A)MTX A2001 (-4.3A)MTX A2001 ( 4.2A)MTX A2001 (-4.3A) | 0.19A | 3ia4A-3tq9A:25.8 | 3ia4A-3tq9A:43.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | ILE A 14PHE A 58ILE A 164THR A 185 | 1CY A 609 (-4.3A)1CY A 609 (-3.5A)1CY A 609 ( 4.0A)1CY A 609 (-4.3A) | 0.34A | 3ia4A-3um6A:20.3 | 3ia4A-3um6A:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vu9 | CHROMOSOMESEGREGATION INMEIOSIS PROTEIN 2 (Saccharomycescerevisiae) |
PF16834(CSM2) | 4 | ILE B 112PHE B 38ILE B 90THR B 161 | None | 1.03A | 3ia4A-3vu9B:undetectable | 3ia4A-3vu9B:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w3e | COTYLEDONEOUSYIELDIN-LIKE PROTEIN (Vignaunguiculata) |
PF00182(Glyco_hydro_19) | 4 | ILE A 197PHE A 156ILE A 196THR A 65 | None | 1.13A | 3ia4A-3w3eA:undetectable | 3ia4A-3w3eA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wlx | LOW SPECIFICITYL-THREONINE ALDOLASE (Escherichiacoli) |
no annotation | 4 | ILE B 170PHE B 171ILE B 193THR B 138 | None | 1.05A | 3ia4A-3wlxB:2.6 | 3ia4A-3wlxB:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2l | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE/RESPONSE (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 4 | ILE A 700PHE A 709ILE A 778THR A 687 | None | 1.16A | 3ia4A-4a2lA:undetectable | 3ia4A-4a2lA:12.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4arx | PESTICIDAL CRYSTALPROTEIN CRY1AC (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | ILE A 466PHE A 605ILE A 518THR A 525 | None | 1.13A | 3ia4A-4arxA:undetectable | 3ia4A-4arxA:13.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d7s | STHK_CNBD_CGMP (Spirochaetathermophila) |
PF00027(cNMP_binding) | 4 | ILE A 329PHE A 366ILE A 328THR A 378 | PCG A1423 (-4.2A)NoneNonePCG A1423 (-3.0A) | 0.91A | 3ia4A-4d7sA:undetectable | 3ia4A-4d7sA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dbh | 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATEISOMERASE (Corynebacteriumglutamicum) |
PF01557(FAA_hydrolase)PF10370(DUF2437) | 4 | ILE A 104PHE A 169ILE A 106THR A 98 | None | 1.14A | 3ia4A-4dbhA:undetectable | 3ia4A-4dbhA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 4 | ILE A 251PHE A 282ILE A 239THR A 243 | None | 1.03A | 3ia4A-4e3aA:undetectable | 3ia4A-4e3aA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4emw | COENZYME A DISULFIDEREDUCTASE (Staphylococcusaureus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | ILE A 31PHE A 67ILE A 73THR A 77 | None | 1.13A | 3ia4A-4emwA:undetectable | 3ia4A-4emwA:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evf | GIARDIN SUBUNITALPHA-1 (Giardiaintestinalis) |
PF00191(Annexin) | 4 | ILE A 205PHE A 178ILE A 201THR A 216 | None | 1.16A | 3ia4A-4evfA:undetectable | 3ia4A-4evfA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f2g | ORNITHINECARBAMOYLTRANSFERASE1 (Burkholderiathailandensis) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | ILE A 51PHE A 117ILE A 104THR A 108 | None | 0.78A | 3ia4A-4f2gA:2.4 | 3ia4A-4f2gA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f6o | METACASPASE-1 (Saccharomycescerevisiae) |
PF00656(Peptidase_C14) | 4 | ILE A 140PHE A 163ILE A 177THR A 181 | None | 1.04A | 3ia4A-4f6oA:undetectable | 3ia4A-4f6oA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fg8 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE 1 (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 276PHE A 252ILE A 122THR A 280 | None | 1.02A | 3ia4A-4fg8A:undetectable | 3ia4A-4fg8A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl0 | AMINOTRANSFERASEALD1 (Arabidopsisthaliana) |
PF00155(Aminotran_1_2) | 4 | ILE A 84PHE A 288ILE A 88THR A 80 | None | 0.90A | 3ia4A-4fl0A:undetectable | 3ia4A-4fl0A:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4flm | S-FORMYLGLUTATHIONEHYDROLASE (Saccharomycescerevisiae) |
PF00756(Esterase) | 4 | ILE A 32PHE A 141ILE A 15THR A 51 | None | 1.08A | 3ia4A-4flmA:undetectable | 3ia4A-4flmA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8z | DIHYDROFOLATEREDUCTASE (Pneumocystisjirovecii) |
PF00186(DHFR_1) | 4 | ILE X 10PHE X 36ILE X 123THR X 144 | TOP X 301 (-4.2A)TOP X 301 (-3.9A)TOP X 301 ( 4.0A)TOP X 301 (-4.5A) | 0.18A | 3ia4A-4g8zX:20.2 | 3ia4A-4g8zX:29.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gaa | MGC78867 PROTEIN (Xenopus laevis) |
PF01433(Peptidase_M1)PF09127(Leuk-A4-hydro_C) | 4 | ILE A 217PHE A 231ILE A 257THR A 215 | None | 0.89A | 3ia4A-4gaaA:undetectable | 3ia4A-4gaaA:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gcm | THIOREDOXINREDUCTASE (Staphylococcusaureus) |
PF07992(Pyr_redox_2) | 4 | ILE A 109PHE A 247ILE A 11THR A 267 | None | 1.11A | 3ia4A-4gcmA:undetectable | 3ia4A-4gcmA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gw9 | BACTERIOPHYTOCHROME (Rhodopseudomonaspalustris) |
PF00360(PHY)PF00989(PAS)PF01590(GAF)PF08446(PAS_2) | 4 | ILE A 494PHE A 324ILE A 353THR A 497 | None | 1.17A | 3ia4A-4gw9A:undetectable | 3ia4A-4gw9A:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gyb | COPPER OXIDASE (Streptomyceslividans) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | ILE A 193PHE A 233ILE A 221THR A 225 | None | 1.01A | 3ia4A-4gybA:undetectable | 3ia4A-4gybA:19.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h96 | DIHYDROFOLATEREDUCTASE (Candidaalbicans) |
PF00186(DHFR_1) | 4 | ILE A 9PHE A 36ILE A 112THR A 133 | 14Q A 202 (-4.3A)14Q A 202 (-4.0A)14Q A 202 ( 4.2A)14Q A 202 ( 4.6A) | 0.29A | 3ia4A-4h96A:18.1 | 3ia4A-4h96A:35.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h98 | DIHYDROFOLATEREDUCTASE ([Candida]glabrata) |
PF00186(DHFR_1) | 4 | ILE A 9PHE A 36ILE A 121THR A 140 | 14Q A 302 (-4.1A)14Q A 302 (-3.8A)14Q A 302 ( 4.0A)14Q A 302 (-4.2A) | 0.28A | 3ia4A-4h98A:19.3 | 3ia4A-4h98A:32.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k4k | PUTATIVE CELLADHESION PROTEIN (Bacteroidesuniformis) |
PF13149(Mfa_like_1) | 4 | ILE A 169PHE A 241ILE A 274THR A 219 | None | 0.96A | 3ia4A-4k4kA:undetectable | 3ia4A-4k4kA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lxl | LYSINE-SPECIFICDEMETHYLASE 4B (Homo sapiens) |
PF02373(JmjC)PF02375(JmjN) | 4 | ILE A 246PHE A 227ILE A 250THR A 244 | None | 0.96A | 3ia4A-4lxlA:undetectable | 3ia4A-4lxlA:18.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m2x | DIHYDROFOLATEREDUCTASE (Mycobacteriumtuberculosis) |
PF00186(DHFR_1) | 4 | ILE A 5PHE A 31ILE A 94THR A 113 | TMQ A 202 (-4.0A)TMQ A 202 (-4.0A)TMQ A 202 ( 3.8A)TMQ A 202 (-4.2A) | 0.22A | 3ia4A-4m2xA:22.9 | 3ia4A-4m2xA:35.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ofg | CGMP-DEPENDENTPROTEIN KINASE (Plasmodiumfalciparum) |
PF00027(cNMP_binding) | 4 | ILE A 446PHE A 481ILE A 445THR A 493 | PCG A 601 ( 4.4A)NoneNonePCG A 601 (-2.7A) | 0.96A | 3ia4A-4ofgA:undetectable | 3ia4A-4ofgA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p0f | SERINE PROTEASEINHIBITOR 4, ISOFORMB (Drosophilamelanogaster) |
PF00079(Serpin) | 4 | ILE A 168PHE A 38ILE A 92THR A 334 | None | 1.06A | 3ia4A-4p0fA:undetectable | 3ia4A-4p0fA:15.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p68 | DIHYDROFOLATEREDUCTASE (Escherichiacoli) |
PF00186(DHFR_1) | 4 | ILE A 5PHE A 31ILE A 94THR A 113 | MTX A 201 (-4.1A)MTX A 201 (-4.1A)MTX A 201 ( 4.3A)MTX A 201 ( 4.5A) | 0.18A | 3ia4A-4p68A:28.0 | 3ia4A-4p68A:55.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pl9 | ETHYLENE RECEPTOR 1 (Arabidopsisthaliana) |
PF02518(HATPase_c) | 4 | ILE A 467PHE A 577ILE A 464THR A 574 | None | 1.10A | 3ia4A-4pl9A:undetectable | 3ia4A-4pl9A:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qx5 | CGMP-DEPENDENTPROTEIN KINASE 1 (Homo sapiens) |
PF00027(cNMP_binding) | 4 | ILE A 264PHE A 305ILE A 263THR A 317 | CMP A 401 (-4.0A)NoneNoneCMP A 401 (-2.9A) | 0.91A | 3ia4A-4qx5A:undetectable | 3ia4A-4qx5A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rk6 | GLUCOSE-RESISTANCEAMYLASE REGULATOR (Weissellaparamesenteroides) |
PF13377(Peripla_BP_3) | 4 | ILE A 244PHE A 199ILE A 179THR A 246 | None | 1.00A | 3ia4A-4rk6A:2.5 | 3ia4A-4rk6A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rqo | L-SERINE DEHYDRATASE (Legionellapneumophila) |
PF03313(SDH_alpha)PF03315(SDH_beta) | 4 | ILE A 214PHE A 6ILE A 211THR A 287 | None | 1.05A | 3ia4A-4rqoA:undetectable | 3ia4A-4rqoA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tx7 | CLASS I CHITINASE (Vignaunguiculata) |
PF00182(Glyco_hydro_19) | 4 | ILE A 242PHE A 201ILE A 241THR A 109 | None | 1.16A | 3ia4A-4tx7A:undetectable | 3ia4A-4tx7A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w7g | DYNEIN LIGHTINTERMEDIATE CHAIN (Chaetomiumthermophilum) |
PF05783(DLIC) | 4 | ILE A 50PHE A 63ILE A 283THR A 94 | None | 1.09A | 3ia4A-4w7gA:undetectable | 3ia4A-4w7gA:13.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8j | PESTICIDAL CRYSTALPROTEIN CRY1AC (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | ILE A 466PHE A 605ILE A 518THR A 525 | None | 1.13A | 3ia4A-4w8jA:undetectable | 3ia4A-4w8jA:9.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y81 | PROTEASOME SUBUNITBETA TYPE-6 (Saccharomycescerevisiae) |
PF00227(Proteasome) | 4 | ILE L 111PHE L 68ILE L 50THR L 109 | None | 1.00A | 3ia4A-4y81L:undetectable | 3ia4A-4y81L:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z07 | CGMP-DEPENDENTPROTEIN KINASE 1 (Homo sapiens) |
PF00027(cNMP_binding) | 4 | ILE A 264PHE A 305ILE A 263THR A 317 | PCG A 402 ( 4.0A)NoneNonePCG A 402 (-2.7A) | 1.02A | 3ia4A-4z07A:undetectable | 3ia4A-4z07A:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c8w | CGMP-DEPENDENTPROTEIN KINASE 2 (Homo sapiens) |
PF00027(cNMP_binding) | 4 | ILE A 196PHE A 231ILE A 195THR A 243 | PCG A 302 ( 4.1A)NoneNonePCG A 302 ( 2.8A) | 1.00A | 3ia4A-5c8wA:undetectable | 3ia4A-5c8wA:24.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5dxv | RETHREADED DHFR (syntheticconstruct) |
PF00186(DHFR_1) | 4 | ILE A 5PHE A 48ILE A 111THR A 130 | NonePEG A 202 ( 3.7A)NoneCME A 140 ( 4.5A) | 0.20A | 3ia4A-5dxvA:16.3 | 3ia4A-5dxvA:42.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5edj | FRPC OPERON PROTEIN (Neisseriameningitidis) |
PF06901(FrpC) | 4 | ILE A 145PHE A 65ILE A 103THR A 232 | None | 1.15A | 3ia4A-5edjA:undetectable | 3ia4A-5edjA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f9p | ANTHRONEOXIDASE-LIKE PROTEIN (Streptomycesambofaciens) |
PF03992(ABM) | 4 | ILE A 116PHE A 61ILE A 4THR A 227 | None | 1.11A | 3ia4A-5f9pA:undetectable | 3ia4A-5f9pA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j48 | CGMP-DEPENDENTPROTEIN KINASE 1 (Homo sapiens) |
PF00027(cNMP_binding) | 4 | ILE A 264PHE A 305ILE A 263THR A 317 | 6FW A 404 (-3.5A)NoneNone6FW A 404 ( 2.8A) | 0.99A | 3ia4A-5j48A:undetectable | 3ia4A-5j48A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kbd | TUMOR PROTEIN P73 (Homo sapiens) |
PF00870(P53) | 4 | ILE A 175PHE A 127ILE A 275THR A 173 | None | 1.07A | 3ia4A-5kbdA:undetectable | 3ia4A-5kbdA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mkm | TWO-DOMAIN LACCASE (Streptomycesgriseoflavus) |
no annotation | 4 | ILE A 194PHE A 234ILE A 222THR A 226 | None | 1.03A | 3ia4A-5mkmA:undetectable | 3ia4A-5mkmA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7z | DNA POLYMERASE IIISUBUNIT BETA (Rickettsiaconorii) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | ILE A 217PHE A 228ILE A 219THR A 234 | None | 1.13A | 3ia4A-5w7zA:undetectable | 3ia4A-5w7zA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wjc | KINETOCHORE PROTEINMIS16 (Schizosaccharomycespombe) |
no annotation | 4 | ILE A 146PHE A 217ILE A 158THR A 162 | None | 1.12A | 3ia4A-5wjcA:undetectable | 3ia4A-5wjcA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x4t | PHOTOACTIVATEDADENYLYL CYCLASE (Cyanobacteria) |
PF00211(Guanylate_cyc)PF04940(BLUF) | 4 | ILE A 7PHE A 47ILE A 45THR A 5 | None | 1.15A | 3ia4A-5x4tA:undetectable | 3ia4A-5x4tA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsq | NUCLEOPROTEIN (Marburgmarburgvirus) |
PF05505(Ebola_NP) | 4 | ILE A 75PHE A 10ILE A 8THR A 12 | None | 1.17A | 3ia4A-5xsqA:undetectable | 3ia4A-5xsqA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y10 | MEMBRANEGLYCOPROTEINPOLYPROTEIN (SFTSphlebovirus) |
PF07243(Phlebovirus_G1) | 4 | ILE C 208PHE C 213ILE C 239THR C 336 | None | 1.16A | 3ia4A-5y10C:undetectable | 3ia4A-5y10C:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6aqj | KETOL-ACIDREDUCTOISOMERASE(NADP(+)) (Staphylococcusaureus) |
no annotation | 4 | ILE A 111PHE A 105ILE A 116THR A 187 | None | 1.17A | 3ia4A-6aqjA:undetectable | 3ia4A-6aqjA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cxm | DIHYDROFOLATEREDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 4 | ILE A 6PHE A 32ILE A 92THR A 111 | MMV A 202 (-4.0A)MMV A 202 (-3.7A)MMV A 202 ( 4.2A)MMV A 202 (-4.4A) | 0.25A | 3ia4A-6cxmA:21.5 | 3ia4A-6cxmA:29.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d46 | BETA SLIDING CLAMP (Rickettsiatyphi) |
no annotation | 4 | ILE A 217PHE A 228ILE A 219THR A 234 | None | 1.14A | 3ia4A-6d46A:undetectable | 3ia4A-6d46A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6u | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITGAMMA-2,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT GAMMA-2 (Homo sapiens) |
no annotation | 4 | ILE E 62PHE E 227ILE E 74THR E 193 | None | 1.13A | 3ia4A-6d6uE:undetectable | 3ia4A-6d6uE:21.01 |