SIMILAR PATTERNS OF AMINO ACIDS FOR 3I5U_B_SAMB401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP1)
PROTEIN (CRICKET
PARALYSIS VIRUS,
VP3)

(Cricket
paralysis
virus;
Cricket
paralysis virus) 		PF08762
(CRPV_capsid)
no annotation 		3 ASP A  23
PHE C 141
SER C 120
 None
 0.90A 3i5uB-1b35A:
undetectable		 3i5uB-1b35A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		3 ASP A 189
PHE A 230
SER A 406
 None
 0.80A 3i5uB-1crzA:
undetectable		 3i5uB-1crzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ASP B 477
PHE B 481
SER B 449
 None
 0.98A 3i5uB-1gl9B:
undetectable		 3i5uB-1gl9B:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		3 ASP A 117
PHE A 114
SER A 159
 None
 1.00A 3i5uB-1igoA:
undetectable		 3i5uB-1igoA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp6 PROTEIN (TOXIN)

(Ustilago maydis) 		no annotation 3 ASP A  56
PHE A  53
SER A  76
 None
 0.77A 3i5uB-1kp6A:
undetectable		 3i5uB-1kp6A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 3 ASP T  51
PHE T  24
SER T  56
 None
 0.69A 3i5uB-1lthT:
7.3		 3i5uB-1lthT:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1moe ANTI-CEA MAB T84.66

(Mus musculus) 		PF07686
(V-set) 		3 ASP A  30
PHE A  36
SER A  56
 None
 0.92A 3i5uB-1moeA:
undetectable		 3i5uB-1moeA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN
CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans;
Oligotropha
carboxidovorans) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ASP A  43
PHE B 728
SER B 306
 None
 1.02A 3i5uB-1n60A:
undetectable		 3i5uB-1n60A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5e SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF09272
(Hepsin-SRCR) 		3 ASP L 107
PHE L  50
SER L  13
 None
 1.01A 3i5uB-1o5eL:
undetectable		 3i5uB-1o5eL:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE

(Saccharomyces
cerevisiae) 		PF01259
(SAICAR_synt) 		3 ASP A  71
PHE A  67
SER A 200
 None
 0.61A 3i5uB-1obgA:
undetectable		 3i5uB-1obgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9c PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2

(Homo sapiens) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		3 ASP A  53
PHE A  46
SER A 237
 None
 0.72A 3i5uB-1s9cA:
undetectable		 3i5uB-1s9cA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR

(Caenorhabditis
elegans) 		PF09287
(CEP1-DNA_bind) 		3 ASP A 320
PHE A 317
SER A 335
 None
 0.96A 3i5uB-1t4wA:
undetectable		 3i5uB-1t4wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASP A 378
PHE A 368
SER A 321
 FE2  A 600 (-2.0A)
None
None
 0.89A 3i5uB-1uliA:
undetectable		 3i5uB-1uliA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ASP X  81
PHE X 269
SER X  89
 DDQ  X 502 (-2.9A)
None
None
 0.86A 3i5uB-1w52X:
undetectable		 3i5uB-1w52X:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wot PUTATIVE MINIMAL
NUCLEOTIDYLTRANSFERA
SE

(Thermus
thermophilus) 		PF01909
(NTP_transf_2) 		3 ASP A  73
PHE A  28
SER A  76
 None
 0.90A 3i5uB-1wotA:
undetectable		 3i5uB-1wotA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm7 HYPOTHETICAL PROTEIN
AQ_1665

(Aquifex
aeolicus) 		PF12850
(Metallophos_2) 		3 ASP A  80
PHE A  90
SER A  85
 None
 0.95A 3i5uB-1xm7A:
undetectable		 3i5uB-1xm7A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Bacillus
anthracis) 		PF00731
(AIRC) 		3 ASP A  44
PHE A  47
SER A  38
 None
 1.00A 3i5uB-1xmpA:
3.6		 3i5uB-1xmpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 ASP A  65
PHE A 105
SER A 157
 None
 1.01A 3i5uB-1xpgA:
undetectable		 3i5uB-1xpgA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		3 ASP A 338
PHE A  37
SER A 335
 None
 0.98A 3i5uB-2i3oA:
undetectable		 3i5uB-2i3oA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF04494
(TFIID_NTD2) 		3 ASP A 207
PHE A 182
SER A 157
 None
 0.93A 3i5uB-2j49A:
undetectable		 3i5uB-2j49A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k9m RNA POLYMERASE SIGMA
FACTOR RPON

(Aquifex
aeolicus) 		PF04963
(Sigma54_CBD) 		3 ASP A 143
PHE A 105
SER A 109
 None
 0.64A 3i5uB-2k9mA:
2.6		 3i5uB-2k9mA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 ASP A 192
PHE A 371
SER A 329
 None
 1.00A 3i5uB-2p4qA:
6.5		 3i5uB-2p4qA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsx PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		3 ASP A 171
PHE A 165
SER A  28
 None
 0.96A 3i5uB-2qsxA:
undetectable		 3i5uB-2qsxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 3 ASP A 336
PHE A 371
SER A 367
 None
 0.92A 3i5uB-2quaA:
undetectable		 3i5uB-2quaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN

(Escherichia
coli) 		PF03349
(Toluene_X) 		3 ASP A  26
PHE A  40
SER A  31
 None
 1.01A 3i5uB-2r8aA:
undetectable		 3i5uB-2r8aA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE

(Staphylococcus
aureus) 		PF00884
(Sulfatase) 		3 ASP A 302
PHE A 305
SER A 321
 None
 0.92A 3i5uB-2w5sA:
undetectable		 3i5uB-2w5sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		3 ASP A 109
PHE A 147
SER A  66
 None
 0.86A 3i5uB-2ymuA:
undetectable		 3i5uB-2ymuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		3 ASP A 191
PHE A 229
SER A 148
 None
 0.90A 3i5uB-2ymuA:
undetectable		 3i5uB-2ymuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		3 ASP A 232
PHE A 270
SER A 189
 None
 0.77A 3i5uB-2ymuA:
undetectable		 3i5uB-2ymuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		3 ASP A 273
PHE A  24
SER A 230
 None
 0.85A 3i5uB-2ymuA:
undetectable		 3i5uB-2ymuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		3 ASP A 314
PHE A 352
SER A 558
 None
 0.65A 3i5uB-2ymuA:
undetectable		 3i5uB-2ymuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		3 ASP A 396
PHE A 434
SER A 353
 None
 0.70A 3i5uB-2ymuA:
undetectable		 3i5uB-2ymuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		3 ASP A 437
PHE A 475
SER A 394
 None
 0.58A 3i5uB-2ymuA:
undetectable		 3i5uB-2ymuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		3 ASP A 519
PHE A 557
SER A 476
 None
 0.76A 3i5uB-2ymuA:
undetectable		 3i5uB-2ymuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		3 ASP A 334
PHE A 270
SER A 263
 SAH  A 900 (-2.7A)
None
SAH  A 900 (-4.2A)
 0.79A 3i5uB-2zfuA:
11.6		 3i5uB-2zfuA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		3 ASP A  26
PHE A 244
SER A  44
 None
 0.96A 3i5uB-3abzA:
3.4		 3i5uB-3abzA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 ASP A 211
PHE A 147
SER A 228
 None
 0.69A 3i5uB-3actA:
undetectable		 3i5uB-3actA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		3 ASP A 434
PHE A 153
SER A 376
 None
 0.78A 3i5uB-3bwsA:
undetectable		 3i5uB-3bwsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		3 ASP A 197
PHE A 166
SER A 124
 PMP  A 401 (-2.7A)
None
SO4  A 402 ( 3.7A)
 0.69A 3i5uB-3cq5A:
4.9		 3i5uB-3cq5A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		3 ASP X  26
PHE X 101
SER X 438
 None
 0.96A 3i5uB-3dwoX:
undetectable		 3i5uB-3dwoX:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg9 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
OXIDOREDUCTASE
PROTEIN

(Ralstonia
solanacearum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ASP A 246
PHE A 175
SER A 217
 None
 0.61A 3i5uB-3gg9A:
6.5		 3i5uB-3gg9A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Lactobacillus
delbrueckii) 		PF06325
(PrmA) 		3 ASP A 143
PHE A 141
SER A 125
 None
 1.01A 3i5uB-3grzA:
9.7		 3i5uB-3grzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASP A 386
PHE A 376
SER A 329
 FE2  A 701 (-1.9A)
None
None
 0.86A 3i5uB-3gzyA:
undetectable		 3i5uB-3gzyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		3 ASP A 174
PHE A 180
SER A 167
 None
 0.96A 3i5uB-3hc1A:
undetectable		 3i5uB-3hc1A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		3 ASP A 200
PHE A 228
SER A 242
 SAH  A 401 (-2.8A)
SAH  A 401 (-3.4A)
SAH  A 401 (-2.8A)
 0.05A 3i5uB-3i58A:
49.4		 3i5uB-3i58A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		3 ASP A 231
PHE A 148
SER A  24
 None
SO4  A 450 (-4.7A)
None
 0.98A 3i5uB-3mznA:
undetectable		 3i5uB-3mznA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 ASP A 235
PHE A 209
SER A 260
 None
 1.00A 3i5uB-3nvaA:
2.0		 3i5uB-3nvaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER

(Staphylococcus
aureus) 		PF04069
(OpuAC) 		3 ASP A 236
PHE A 142
SER A 221
 None
 1.00A 3i5uB-3o66A:
undetectable		 3i5uB-3o66A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		3 ASP A  23
PHE A  26
SER A  55
 None
 1.00A 3i5uB-3ou6A:
14.4		 3i5uB-3ou6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		3 ASP X 170
PHE X 148
SER X 240
 None
 0.95A 3i5uB-3pb9X:
undetectable		 3i5uB-3pb9X:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		3 ASP A 356
PHE A 271
SER A 398
 None
 0.79A 3i5uB-3r0zA:
2.6		 3i5uB-3r0zA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		3 ASP A1189
PHE A1230
SER A1136
 None
 0.93A 3i5uB-3sfzA:
5.8		 3i5uB-3sfzA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		3 ASP X 358
PHE X 273
SER X 400
 None
 0.88A 3i5uB-3ss7X:
2.0		 3i5uB-3ss7X:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		3 ASP A 295
PHE A 538
SER A  97
 None
 0.82A 3i5uB-3t8lA:
2.0		 3i5uB-3t8lA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 ASP A 272
PHE A 275
SER A 822
 None
 0.80A 3i5uB-3vuoA:
undetectable		 3i5uB-3vuoA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		3 ASP A 193
PHE A 195
SER A  69
 SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
None
 0.91A 3i5uB-3vywA:
8.7		 3i5uB-3vywA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ASP A 215
PHE A 321
SER A 284
 None
 0.91A 3i5uB-4bc5A:
undetectable		 3i5uB-4bc5A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 ASP A 621
PHE A 624
SER A 531
 None
 1.02A 3i5uB-4cyjA:
undetectable		 3i5uB-4cyjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE

(Pectobacterium
carotovorum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A  33
PHE A 353
SER A 317
 None
 0.99A 3i5uB-4e4fA:
undetectable		 3i5uB-4e4fA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9u CG32412

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		3 ASP A 116
PHE A  94
SER A 185
 None
 0.76A 3i5uB-4f9uA:
undetectable		 3i5uB-4f9uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT

(Burkholderia
cenocepacia) 		PF00731
(AIRC) 		3 ASP A  55
PHE A  58
SER A  49
 None
 1.02A 3i5uB-4grdA:
3.7		 3i5uB-4grdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		3 ASP A  85
PHE A  83
SER A 134
 None
 0.90A 3i5uB-4ixoA:
undetectable		 3i5uB-4ixoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcd MAJOR CAPSID PROTEIN
VP1

(Human
polyomavirus 2) 		PF00718
(Polyoma_coat) 		3 ASP A 166
PHE A 170
SER A  71
 None
None
GOL  A 301 (-4.7A)
 0.99A 3i5uB-4jcdA:
undetectable		 3i5uB-4jcdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4juu EPIMERASE

(Xanthomonas
campestris) 		PF05544
(Pro_racemase) 		3 ASP A 156
PHE A 165
SER A 212
 None
 0.93A 3i5uB-4juuA:
undetectable		 3i5uB-4juuA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		3 ASP A 595
PHE A 809
SER A 608
 None
 0.91A 3i5uB-4krfA:
2.2		 3i5uB-4krfA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		3 ASP A 130
PHE A 108
SER A 198
 None
 0.96A 3i5uB-4mhpA:
undetectable		 3i5uB-4mhpA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1x GAMMA-HEMOLYSIN
COMPONENT C

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 ASP B  86
PHE B 226
SER B 151
 None
 0.95A 3i5uB-4p1xB:
undetectable		 3i5uB-4p1xB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r40 PROTEIN TOLB

(Yersinia pestis) 		PF04052
(TolB_N)
PF07676
(PD40) 		3 ASP A 210
PHE A 251
SER A 427
 None
 0.99A 3i5uB-4r40A:
undetectable		 3i5uB-4r40A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		3 ASP C 618
PHE C 621
SER C 573
 None
 0.95A 3i5uB-4u1cC:
2.7		 3i5uB-4u1cC:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3C

(Lachancea
kluyveri) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		3 ASP c 618
PHE c 621
SER c 573
 None
 0.95A 3i5uB-4uerc:
2.6		 3i5uB-4uerc:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uft NUCLEOPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap) 		3 ASP B 125
PHE B 116
SER B 107
 None
 1.01A 3i5uB-4uftB:
undetectable		 3i5uB-4uftB:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASP A 185
PHE A 184
SER A 191
 None
 0.95A 3i5uB-4w8jA:
undetectable		 3i5uB-4w8jA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		3 ASP A 605
PHE A 582
SER A 546
 None
 1.00A 3i5uB-4xjxA:
2.7		 3i5uB-4xjxA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Saccharomyces
cerevisiae) 		no annotation 3 ASP L 359
PHE L 357
SER L 340
 None
 0.99A 3i5uB-4xr7L:
undetectable		 3i5uB-4xr7L:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		3 ASP A  42
PHE A  58
SER A  68
 None
 0.98A 3i5uB-4y9wA:
undetectable		 3i5uB-4y9wA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ASP A 167
PHE A 165
SER A  95
 None
 1.01A 3i5uB-4yzwA:
undetectable		 3i5uB-4yzwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Paraburkholderia
xenovorans) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASP A 388
PHE A 378
SER A 331
 FE2  A 461 (-2.2A)
None
None
 0.73A 3i5uB-5aewA:
undetectable		 3i5uB-5aewA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		3 ASP A 379
PHE A 398
SER A 391
 ZN  A 703 (-2.3A)
4ZN  A 704 (-4.9A)
SO4  A 709 (-3.9A)
 0.97A 3i5uB-5cbmA:
undetectable		 3i5uB-5cbmA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		3 ASP A 103
PHE A 518
SER A 106
 None
 0.94A 3i5uB-5d6aA:
undetectable		 3i5uB-5d6aA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 ASP A 189
PHE A 173
SER A 330
 None
 0.93A 3i5uB-5dkxA:
undetectable		 3i5uB-5dkxA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ASP A 626
PHE A 594
SER A 332
 None
 1.00A 3i5uB-5dmyA:
2.3		 3i5uB-5dmyA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		3 ASP A 931
PHE A 857
SER A 937
 None
 0.93A 3i5uB-5ehkA:
2.2		 3i5uB-5ehkA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		3 ASP A 183
PHE A 127
SER A 122
 None
 0.78A 3i5uB-5gw8A:
undetectable		 3i5uB-5gw8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		3 ASP C 273
PHE C 312
SER C 290
 None
 0.96A 3i5uB-5k1cC:
undetectable		 3i5uB-5k1cC:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5

(Candida
albicans) 		PF00080
(Sod_Cu) 		3 ASP A 132
PHE A  48
SER A 143
 None
 1.00A 3i5uB-5kbmA:
undetectable		 3i5uB-5kbmA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRP46

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ASP J 408
PHE J 155
SER J 405
 None
 0.79A 3i5uB-5lj3J:
undetectable		 3i5uB-5lj3J:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP A 824
PHE A1074
SER A 679
 None
 0.82A 3i5uB-5lstA:
3.3		 3i5uB-5lstA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		3 ASP A1701
PHE A1875
SER A1704
 None
None
EDO  A2029 (-2.2A)
 0.68A 3i5uB-5mznA:
undetectable		 3i5uB-5mznA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 3 ASP A 507
PHE A 229
SER A 143
 None
 0.80A 3i5uB-5n6vA:
undetectable		 3i5uB-5n6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ASP A 208
PHE A 283
SER A 148
 None
 0.86A 3i5uB-5oljA:
undetectable		 3i5uB-5oljA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		3 ASP E 124
PHE E  86
SER E 627
 None
 1.00A 3i5uB-5u8sE:
3.2		 3i5uB-5u8sE:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxl INVASIN IPAD

(Shigella
flexneri) 		PF06511
(IpaD) 		3 ASP A 287
PHE A 283
SER A 172
 None
 0.94A 3i5uB-5vxlA:
undetectable		 3i5uB-5vxlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 ASP A  78
PHE A 101
SER A 139
 None
 0.98A 3i5uB-5weoA:
undetectable		 3i5uB-5weoA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wj8 CADHERIN-23

(Homo sapiens) 		no annotation 3 ASP A1487
PHE A1395
SER A1392
 None
 0.99A 3i5uB-5wj8A:
undetectable		 3i5uB-5wj8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmb DNA REPAIR PROTEIN
REV1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 467
PHE A 448
SER A 507
 MG  A 801 (-2.2A)
None
None
 0.77A 3i5uB-5wmbA:
undetectable		 3i5uB-5wmbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y50 PROTEIN
DETOXIFICATION 14

(Arabidopsis
thaliana) 		no annotation 3 ASP A 400
PHE A 254
SER A 396
 None
 0.95A 3i5uB-5y50A:
undetectable		 3i5uB-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5b METHYLTRANSFERASE

(Lysobacter
antibioticus) 		no annotation 3 ASP A 205
PHE A 233
SER A 247
 SAH  A 501 (-2.9A)
SAH  A 501 (-3.5A)
SAH  A 501 (-2.8A)
 0.41A 3i5uB-6c5bA:
36.0		 3i5uB-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6t HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2

(Homo sapiens) 		no annotation 3 ASP E 161
PHE E 201
SER E 164
 None
 0.94A 3i5uB-6d6tE:
undetectable		 3i5uB-6d6tE:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fju -

(-) 		no annotation 3 ASP A  96
PHE A  91
SER A  84
 ZN  A 301 (-2.5A)
None
None
 0.75A 3i5uB-6fjuA:
undetectable		 3i5uB-6fjuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fno -

(-) 		no annotation 3 ASP A  96
PHE A  91
SER A  84
 ZN  A 201 (-2.1A)
None
None
 0.82A 3i5uB-6fnoA:
undetectable		 3i5uB-6fnoA:
undetectable