SIMILAR PATTERNS OF AMINO ACIDS FOR 3I5U_A_SAMA401
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1clw | TAILSPIKE PROTEIN (Salmonellavirus P22) |
PF09251(PhageP22-tail) | 5 | HIS A 420LEU A 419GLY A 367LEU A 337ASP A 395 | None | 1.05A | 3i5uA-1clwA:undetectable | 3i5uA-1clwA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1clw | TAILSPIKE PROTEIN (Salmonellavirus P22) |
PF09251(PhageP22-tail) | 5 | HIS A 420LEU A 419GLY A 367LEU A 337ASP A 395 | None | 1.18A | 3i5uA-1clwA:undetectable | 3i5uA-1clwA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d8c | MALATE SYNTHASE G (Escherichiacoli) |
PF01274(Malate_synthase) | 5 | HIS A 342LEU A 53GLY A 395LEU A 435ALA A 402 | None | 1.04A | 3i5uA-1d8cA:undetectable | 3i5uA-1d8cA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e1k | ADRENODOXINREDUCTASE (Bos taurus) |
PF07992(Pyr_redox_2) | 5 | LEU A 46GLY A 128LEU A 449PRO A 134ASP A 175 | FAD A 801 (-3.5A)NoneNoneNoneNone | 1.13A | 3i5uA-1e1kA:3.8 | 3i5uA-1e1kA:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efp | PROTEIN (ELECTRONTRANSFERFLAVOPROTEIN)PROTEIN (ELECTRONTRANSFERFLAVOPROTEIN) (Paracoccusdenitrificans;Paracoccusdenitrificans) |
PF00766(ETF_alpha)PF01012(ETF)PF01012(ETF) | 5 | LEU A 190GLY A 242GLY A 245LEU B 182ALA A 225 | NoneFAD A 399 (-3.1A)FAD A 399 (-4.6A)FAD A 399 (-4.6A)None | 1.05A | 3i5uA-1efpA:undetectable | 3i5uA-1efpA:25.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fp2 | ISOFLAVONEO-METHYLTRANSFERASE (Medicago sativa) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 6 | TRP A 151PHE A 164MET A 168GLY A 197GLY A 198TRP A 259 | SAH A1699 ( 3.8A)HMO A2000 (-4.9A)HMO A2000 ( 4.0A)SAH A1699 ( 4.2A)SAH A1699 ( 3.9A)None | 0.63A | 3i5uA-1fp2A:29.6 | 3i5uA-1fp2A:25.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fp2 | ISOFLAVONEO-METHYLTRANSFERASE (Medicago sativa) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | TRP A 151PHE A 164MET A 168GLY A 198TRP A 259 | SAH A1699 ( 3.8A)HMO A2000 (-4.9A)HMO A2000 ( 4.0A)SAH A1699 ( 3.9A)None | 0.98A | 3i5uA-1fp2A:29.6 | 3i5uA-1fp2A:25.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fpq | ISOLIQUIRITIGENIN2'-O-METHYLTRANSFERASE (Medicago sativa) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 218GLY A 219LEU A 241ALA A 275TRP A 280 | NoneNoneSAM A1699 (-4.2A)SAM A1699 (-3.5A)None | 0.32A | 3i5uA-1fpqA:14.8 | 3i5uA-1fpqA:27.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j93 | UROPORPHYRINOGENDECARBOXYLASE (Nicotianatabacum) |
PF01208(URO-D) | 5 | PHE A 105LEU A 84GLY A 164GLY A 163PRO A 107 | None | 1.11A | 3i5uA-1j93A:undetectable | 3i5uA-1j93A:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jcf | RODSHAPE-DETERMININGPROTEIN MREB (Thermotogamaritima) |
PF06723(MreB_Mbl) | 5 | LEU A 16GLY A 286GLY A 285ALA A 13ASP A 180 | None | 1.12A | 3i5uA-1jcfA:undetectable | 3i5uA-1jcfA:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m3u | 3-METHYL-2-OXOBUTANOATEHYDROXYMETHYLTRANSFERASE (Escherichiacoli) |
PF02548(Pantoate_transf) | 5 | MET A 215HIS A 216GLY A 44LEU A 81ASP A 26 | NoneNoneKPL A 265 (-3.2A)NoneNone | 1.19A | 3i5uA-1m3uA:undetectable | 3i5uA-1m3uA:24.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qzz | ACLACINOMYCIN-10-HYDROXYLASE (Streptomycespurpurascens) |
PF00891(Methyltransf_2) | 6 | TRP A 146GLY A 191GLY A 192LEU A 214PRO A 217TRP A 261 | SAM A 635 (-4.2A)SAM A 635 ( 3.2A)SAM A 635 (-3.5A)SAM A 635 (-4.2A)SAM A 635 (-4.6A)None | 0.77A | 3i5uA-1qzzA:35.3 | 3i5uA-1qzzA:43.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uls | PUTATIVE3-OXOACYL-ACYLCARRIER PROTEINREDUCTASE (Thermusthermophilus) |
PF13561(adh_short_C2) | 5 | GLY A 18GLY A 16LEU A 210PRO A 209ALA A 45 | None | 1.07A | 3i5uA-1ulsA:6.0 | 3i5uA-1ulsA:25.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3q | THAUMATIN-LIKEPROTEIN (Musa acuminata) |
PF00314(Thaumatin) | 5 | PHE A 3GLY A 41GLY A 42PRO A 19ASP A 93 | None | 1.19A | 3i5uA-1z3qA:undetectable | 3i5uA-1z3qA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a9c | SULFITE OXIDASE (Gallus gallus) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 5 | PHE A 136LEU A 345GLY A 187LEU A 202ALA A 297 | MTE A1501 (-3.5A)NoneNoneSO4 A7503 (-3.8A)MTE A1501 (-3.7A) | 1.07A | 3i5uA-2a9cA:undetectable | 3i5uA-2a9cA:26.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4g | DIHYDROOROTATEDEHYDROGENASE (Trypanosomabrucei) |
PF01180(DHO_dh) | 5 | HIS A 261GLY A 222GLY A 223LEU A 64ALA A 230 | NoneFMN A1400 (-3.7A)FMN A1400 (-3.4A)NoneNone | 1.16A | 3i5uA-2b4gA:undetectable | 3i5uA-2b4gA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bkl | PROLYL ENDOPEPTIDASE (Myxococcusxanthus) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 5 | PHE A 627GLY A 535GLY A 536PRO A 558ALA A 542 | None | 1.13A | 3i5uA-2bklA:undetectable | 3i5uA-2bklA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bx7 | DIHYDROOROTATEDEHYDROGENASE (Lactococcuslactis) |
PF01180(DHO_dh) | 5 | HIS A 260GLY A 220GLY A 221LEU A 63ALA A 228 | NoneFMN A1312 ( 3.8A)FMN A1312 (-3.6A)NoneNone | 1.20A | 3i5uA-2bx7A:undetectable | 3i5uA-2bx7A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ecf | DIPEPTIDYL PEPTIDASEIV (Stenotrophomonasmaltophilia) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | MET A 618LEU A 619GLY A 612GLY A 613PRO A 635 | None | 1.12A | 3i5uA-2ecfA:undetectable | 3i5uA-2ecfA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hj9 | AUTOINDUCER2-BINDINGPERIPLASMIC PROTEINLUXP (Vibrio harveyi) |
PF13407(Peripla_BP_4) | 5 | PHE A 178GLY A 291GLY A 290ALA A 359ASP A 313 | NoneNoneAI2 A 501 ( 4.6A)NoneNone | 1.22A | 3i5uA-2hj9A:2.4 | 3i5uA-2hj9A:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ics | ADENINE DEAMINASE (Enterococcusfaecalis) |
PF01979(Amidohydro_1) | 5 | HIS A 195GLY A 166LEU A 128PRO A 169ALA A 192 | None | 1.20A | 3i5uA-2icsA:undetectable | 3i5uA-2icsA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijz | PROBABLE M18-FAMILYAMINOPEPTIDASE 2 (Pseudomonasaeruginosa) |
PF02127(Peptidase_M18) | 5 | HIS A 82GLY A 111GLY A 110LEU A 88ASP A 236 | None | 0.99A | 3i5uA-2ijzA:undetectable | 3i5uA-2ijzA:25.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7v | TLL2115 PROTEIN (Synechococcuselongatus) |
PF13354(Beta-lactamase2) | 5 | LEU A 11GLY A 182GLY A 180LEU A 193TRP A 147 | None | 1.08A | 3i5uA-2j7vA:undetectable | 3i5uA-2j7vA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o8r | POLYPHOSPHATE KINASE (Porphyromonasgingivalis) |
PF02503(PP_kinase)PF13089(PP_kinase_N)PF13090(PP_kinase_C) | 5 | HIS A 595LEU A 593GLY A 569LEU A 565TRP A 616 | SO4 A 707 (-3.8A)NoneNoneNoneNone | 1.14A | 3i5uA-2o8rA:undetectable | 3i5uA-2o8rA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4g | HYPOTHETICAL PROTEIN (Corynebacteriumdiphtheriae) |
PF01872(RibD_C) | 5 | LEU A 227GLY A 194GLY A 195LEU A 114ALA A 37 | NoneEDO A 280 ( 4.1A)EDO A 272 ( 3.1A)NoneNone | 1.22A | 3i5uA-2p4gA:undetectable | 3i5uA-2p4gA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3o | 12-OXOPHYTODIENOATEREDUCTASE 3 (Arabidopsisthaliana) |
PF00724(Oxidored_FMN) | 5 | PHE A 317MET A 306LEU A 305GLY A 257LEU A 264 | None | 1.20A | 3i5uA-2q3oA:undetectable | 3i5uA-2q3oA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qe8 | UNCHARACTERIZEDPROTEIN (Trichormusvariabilis) |
PF03022(MRJP) | 5 | GLY A 198LEU A 194PRO A 138ASP A 293TRP A 291 | UNL A 344 (-3.6A)GOL A 346 ( 4.7A)NoneUNL A 344 (-2.7A)None | 1.18A | 3i5uA-2qe8A:undetectable | 3i5uA-2qe8A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyo | O-METHYLTRANSFERASE (Medicagotruncatula) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 202GLY A 203ALA A 259ASP A 263TRP A 264 | SAH A 601 ( 4.3A)SAH A 601 ( 3.8A)SAH A 601 (-3.9A)QSO A 701 (-3.9A)None | 0.50A | 3i5uA-2qyoA:19.7 | 3i5uA-2qyoA:26.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyt | 2-DEHYDROPANTOATE2-REDUCTASE (Porphyromonasgingivalis) |
PF02558(ApbA)PF08546(ApbA_C) | 5 | LEU A 55GLY A 14GLY A 17LEU A 114ALA A 41 | NoneEDO A 320 ( 3.3A)EDO A 320 (-3.6A)NoneSO4 A 316 (-3.6A) | 1.20A | 3i5uA-2qytA:5.5 | 3i5uA-2qytA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu5 | SUCCINATEDEHYDROGENASEFLAVOPROTEIN SUBUNIT (Escherichiacoli) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | LEU A 169GLY A 222GLY A 224LEU A 519ALA A 166 | NoneNoneNoneNoneFAD A 601 (-3.2A) | 1.03A | 3i5uA-2wu5A:undetectable | 3i5uA-2wu5A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu5 | SUCCINATEDEHYDROGENASEFLAVOPROTEIN SUBUNIT (Escherichiacoli) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | LEU A 169GLY A 230LEU A 560PRO A 561ALA A 368 | None | 1.22A | 3i5uA-2wu5A:undetectable | 3i5uA-2wu5A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wzf | GLUCOSYLTRANSFERASE (Legionellapneumophila) |
PF16849(Glyco_transf_88) | 5 | PHE A 117GLY A 264GLY A 265ALA A 489TRP A 503 | None | 1.22A | 3i5uA-2wzfA:undetectable | 3i5uA-2wzfA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x66 | PRNB (Pseudomonasfluorescens) |
PF08933(DUF1864) | 5 | PHE A 76LEU A 205GLY A 133LEU A 31PRO A 34 | None | 0.99A | 3i5uA-2x66A:undetectable | 3i5uA-2x66A:26.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x7m | ARCHAEMETZINCIN (Methanopyruskandleri) |
PF07998(Peptidase_M54) | 5 | PHE A 159MET A 143HIS A 125GLY A 132LEU A 171 | NoneNone ZN A1174 (-3.2A)NoneNone | 1.20A | 3i5uA-2x7mA:undetectable | 3i5uA-2x7mA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a21 | PUTATIVE SECRETEDALPHA-GALACTOSIDASE (Streptomycesavermitilis) |
PF00652(Ricin_B_lectin)PF16499(Melibiase_2) | 5 | HIS A 379LEU A 354GLY A 420GLY A 421ALA A 377 | NoneGOL A 915 (-4.1A)NoneNoneNone | 1.10A | 3i5uA-3a21A:undetectable | 3i5uA-3a21A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c5w | PP2A-SPECIFICMETHYLESTERASE PME-1 (Homo sapiens) |
PF12697(Abhydrolase_6) | 5 | HIS P 164GLY P 158GLY P 159ALA P 128TRP P 298 | None | 1.21A | 3i5uA-3c5wP:undetectable | 3i5uA-3c5wP:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g5s | METHYLENETETRAHYDROFOLATE--TRNA-(URACIL-5-)-METHYLTRANSFERASE TRMFO (Thermusthermophilus) |
PF01134(GIDA) | 5 | LEU A 66GLY A 377GLY A 376PRO A 369ALA A 395 | None | 1.20A | 3i5uA-3g5sA:undetectable | 3i5uA-3g5sA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gov | MASP-1 (Homo sapiens) |
PF00089(Trypsin) | 5 | MET B 650LEU B 662GLY B 647GLY B 648TRP B 668 | None | 1.20A | 3i5uA-3govB:undetectable | 3i5uA-3govB:20.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gxo | MMCR (Streptomyceslavendulae) |
PF00891(Methyltransf_2) | 5 | TRP A 146MET A 163GLY A 192ASP A 260TRP A 261 | SAH A 350 ( 4.0A)SAH A 350 ( 3.7A)SAH A 350 (-3.6A)MQA A 351 (-2.8A)None | 1.08A | 3i5uA-3gxoA:36.0 | 3i5uA-3gxoA:35.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gxo | MMCR (Streptomyceslavendulae) |
PF00891(Methyltransf_2) | 7 | TRP A 146PHE A 159MET A 163GLY A 191GLY A 192ASP A 260TRP A 261 | SAH A 350 ( 4.0A)MQA A 351 (-4.6A)SAH A 350 ( 3.7A)SAH A 350 (-3.6A)SAH A 350 (-3.6A)MQA A 351 (-2.8A)None | 0.66A | 3i5uA-3gxoA:36.0 | 3i5uA-3gxoA:35.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3heo | MYOGLOBIN (Equus caballus) |
PF00042(Globin) | 5 | TRP A 7LEU A 89GLY A 74GLY A 73LEU A 11 | NoneHEM A 154 (-4.6A)NoneNoneNone | 1.09A | 3i5uA-3heoA:undetectable | 3i5uA-3heoA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hoa | THERMOSTABLECARBOXYPEPTIDASE 1 (Thermusthermophilus) |
PF02074(Peptidase_M32) | 5 | TRP A 323PHE A 223LEU A 240GLY A 273GLY A 270 | None | 1.19A | 3i5uA-3hoaA:undetectable | 3i5uA-3hoaA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4j | AMINOTRANSFERASE,CLASS III (Deinococcusradiodurans) |
PF00202(Aminotran_3) | 5 | HIS A 45LEU A 23GLY A 34LEU A 353ALA A 41 | None | 1.20A | 3i5uA-3i4jA:undetectable | 3i5uA-3i4jA:26.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3i58 | O-METHYLTRANSFERASE (Streptomycescarzinostaticus) |
PF00891(Methyltransf_2) | 7 | PHE A 146MET A 150HIS A 153GLY A 177LEU A 201PRO A 204ALA A 243 | None7NA A 402 ( 3.6A)7NA A 402 (-4.1A)SAH A 401 (-3.9A)SAH A 401 (-4.4A)SAH A 401 ( 4.7A)7NA A 402 ( 3.7A) | 0.96A | 3i5uA-3i58A:49.7 | 3i5uA-3i58A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3i58 | O-METHYLTRANSFERASE (Streptomycescarzinostaticus) |
PF00891(Methyltransf_2) | 12 | TRP A 133PHE A 146MET A 150HIS A 153LEU A 154GLY A 178GLY A 179LEU A 201PRO A 204ALA A 243ASP A 247TRP A 248 | SAH A 401 (-3.8A)None7NA A 402 ( 3.6A)7NA A 402 (-4.1A)SAH A 401 ( 4.7A)SAH A 401 (-3.6A)SAH A 401 (-3.6A)SAH A 401 (-4.4A)SAH A 401 ( 4.7A)7NA A 402 ( 3.7A)SAH A 401 (-4.6A)None | 0.21A | 3i5uA-3i58A:49.7 | 3i5uA-3i58A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jq1 | SUSD SUPERFAMILYPROTEIN (Bacteroidesvulgatus) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 5 | PHE A 111MET A 107LEU A 103GLY A 66GLY A 63 | None | 1.15A | 3i5uA-3jq1A:undetectable | 3i5uA-3jq1A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3klj | NAD(FAD)-DEPENDENTDEHYDROGENASE,NIRB-FAMILY(N-TERMINAL DOMAIN) (Clostridiumacetobutylicum) |
PF07992(Pyr_redox_2) | 5 | GLY A 184GLY A 185LEU A 192PRO A 175ALA A 345 | None | 1.20A | 3i5uA-3kljA:undetectable | 3i5uA-3kljA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l84 | TRANSKETOLASE (Campylobacterjejuni) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | PHE A 439HIS A 435GLY A 361LEU A 365ALA A 395 | None | 1.16A | 3i5uA-3l84A:undetectable | 3i5uA-3l84A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lot | UNCHARACTERIZEDPROTEIN (Archaeoglobusfulgidus) |
PF05853(BKACE) | 5 | PHE A 200LEU A 248GLY A 253GLY A 254ASP A 223 | None | 1.20A | 3i5uA-3lotA:undetectable | 3i5uA-3lotA:25.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mhu | DIHYDROOROTATEDEHYDROGENASE (Leishmaniamajor) |
PF01180(DHO_dh) | 5 | HIS A 261GLY A 222GLY A 223LEU A 64ALA A 230 | NoneFMN A 313 (-3.6A)FMN A 313 (-3.3A)NoneNone | 1.16A | 3i5uA-3mhuA:undetectable | 3i5uA-3mhuA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nu1 | HEMIN-BINDINGPERIPLASMIC PROTEIN (Yersinia pestis) |
PF01497(Peripla_BP_2) | 5 | LEU A 268GLY A 190GLY A 189PRO A 156ALA A 183 | None | 1.22A | 3i5uA-3nu1A:2.4 | 3i5uA-3nu1A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nv9 | MALIC ENZYME (Entamoebahistolytica) |
PF00390(malic)PF03949(Malic_M) | 5 | PHE A 363LEU A 371GLY A 129GLY A 128ALA A 132 | None | 1.12A | 3i5uA-3nv9A:3.1 | 3i5uA-3nv9A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oix | PUTATIVEDIHYDROOROTATEDEHYDROGENASE DIHYDROOROTATEOXIDASE (Streptococcusmutans) |
PF01180(DHO_dh) | 5 | HIS A 259GLY A 219GLY A 220LEU A 65ALA A 227 | NoneFMN A 400 (-3.7A)FMN A 400 (-3.4A)NoneNone | 1.11A | 3i5uA-3oixA:undetectable | 3i5uA-3oixA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9c | CAFFEIC ACIDO-METHYLTRANSFERASE (Lolium perenne) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 206GLY A 207LEU A 229ASP A 267TRP A 268 | SAH A 401 ( 4.0A)SAH A 401 (-3.6A)SAH A 401 (-4.3A)NoneNone | 0.58A | 3i5uA-3p9cA:25.8 | 3i5uA-3p9cA:29.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r18 | SULFITE OXIDASE (Gallus gallus) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 5 | PHE A 136LEU A 345GLY A 187LEU A 202ALA A 297 | MTE A 501 (-3.3A)NoneNoneNoneMTE A 501 (-3.9A) | 1.13A | 3i5uA-3r18A:undetectable | 3i5uA-3r18A:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rcm | TATD FAMILYHYDROLASE (Pseudomonasputida) |
PF01026(TatD_DNase) | 5 | PHE A 131HIS A 133GLY A 38LEU A 36ASP A 209 | None ZN A 288 ( 3.2A)NoneNoneCIT A 289 (-3.3A) | 1.21A | 3i5uA-3rcmA:undetectable | 3i5uA-3rcmA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttf | TRANSCRIPTIONALREGULATORY PROTEIN (Escherichiacoli) |
PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 5 | TRP A 657HIS A 669LEU A 703GLY A 631ALA A 665 | None | 1.20A | 3i5uA-3ttfA:undetectable | 3i5uA-3ttfA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u9r | METHYLCROTONYL-COACARBOXYLASE,BETA-SUBUNIT (Pseudomonasaeruginosa) |
PF01039(Carboxyl_trans) | 5 | HIS B 75LEU B 82GLY B 67GLY B 68ALA B 138 | None | 1.22A | 3i5uA-3u9rB:undetectable | 3i5uA-3u9rB:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v48 | PUTATIVEAMINOACRYLATEHYDROLASE RUTD (Escherichiacoli) |
PF00561(Abhydrolase_1) | 5 | PHE A 125HIS A 237LEU A 148GLY A 23ALA A 88 | NoneSCN A 270 (-3.8A)GOL A 267 (-4.7A)GOL A 267 ( 3.5A)SCN A 270 (-3.3A) | 1.04A | 3i5uA-3v48A:undetectable | 3i5uA-3v48A:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wp9 | ICE-BINDING PROTEIN (Colwellia sp.SLW05) |
PF11999(DUF3494) | 5 | PHE A 164LEU A 154GLY A 199GLY A 181LEU A 202 | None | 1.16A | 3i5uA-3wp9A:undetectable | 3i5uA-3wp9A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a05 | CELLOBIOHYDROLASEFAMILY 6 (Chaetomiumthermophilum) |
PF01341(Glyco_hydro_6) | 5 | LEU A 469GLY A 428GLY A 427PRO A 426ALA A 140 | NoneNoneNoneCBI A 502 (-4.3A)None | 1.22A | 3i5uA-4a05A:undetectable | 3i5uA-4a05A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a6e | HYDROXYINDOLEO-METHYLTRANSFERASE (Homo sapiens) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 5 | PHE A 156GLY A 188GLY A 189ASP A 256TRP A 257 | ASE A1350 ( 4.9A)SAM A1349 ( 4.0A)SAM A1349 ( 3.8A)ASE A1350 ( 2.9A)None | 0.54A | 3i5uA-4a6eA:30.8 | 3i5uA-4a6eA:27.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aec | CYSTEINE SYNTHASE,MITOCHONDRIAL (Arabidopsisthaliana) |
PF00291(PALP) | 5 | LEU A 253GLY A 189GLY A 187LEU A 216ALA A 194 | None | 1.22A | 3i5uA-4aecA:2.2 | 3i5uA-4aecA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bq4 | B-AGARASE (Saccharophagusdegradans) |
PF02449(Glyco_hydro_42) | 5 | MET A 340GLY A 756GLY A 751PRO A 748ALA A 408 | None | 0.92A | 3i5uA-4bq4A:undetectable | 3i5uA-4bq4A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 5 | MET A 747HIS A 750GLY A 742GLY A 743LEU A 663 | NoneNoneNoneNoneAGS A1985 (-4.2A) | 1.00A | 3i5uA-4crsA:undetectable | 3i5uA-4crsA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dfs | GLYCOSIDE HYDROLASE,FAMILY 16 (Thermotogapetrophila) |
PF00722(Glyco_hydro_16) | 5 | HIS A 141LEU A 139GLY A 230GLY A 229ASP A 237 | None | 1.22A | 3i5uA-4dfsA:undetectable | 3i5uA-4dfsA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eb0 | LCC (unculturedbacterium) |
PF12695(Abhydrolase_5) | 5 | PHE A 196GLY A 167GLY A 168ALA A 132ASP A 129 | None | 1.21A | 3i5uA-4eb0A:2.3 | 3i5uA-4eb0A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evi | CONIFERYL ALCOHOL9-O-METHYLTRANSFERASE (Linumnodiflorum) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | MET A 179GLY A 209LEU A 232ASP A 272TRP A 273 | SAH A 401 (-3.6A)SAH A 401 ( 3.9A)SAH A 401 ( 4.4A)C9M A 402 ( 2.3A)None | 1.06A | 3i5uA-4eviA:25.3 | 3i5uA-4eviA:27.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evi | CONIFERYL ALCOHOL9-O-METHYLTRANSFERASE (Linumnodiflorum) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 7 | PHE A 175MET A 179GLY A 209GLY A 210LEU A 232ASP A 272TRP A 273 | SAH A 401 (-4.8A)SAH A 401 (-3.6A)SAH A 401 ( 3.9A)SAH A 401 ( 3.8A)SAH A 401 ( 4.4A)C9M A 402 ( 2.3A)None | 0.52A | 3i5uA-4eviA:25.3 | 3i5uA-4eviA:27.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezd | UREA TRANSPORTER 1 (Bos taurus) |
PF03253(UT) | 5 | LEU A 345GLY A 293GLY A 294PRO A 365ALA A 288 | None | 1.22A | 3i5uA-4ezdA:undetectable | 3i5uA-4ezdA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hr3 | PUTATIVE ACYL-COADEHYDROGENASE (Mycobacteroidesabscessus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | GLY A 233GLY A 232PRO A 231ALA A 141ASP A 110 | None | 1.13A | 3i5uA-4hr3A:undetectable | 3i5uA-4hr3A:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwv | PECTATE LYASE/AMBALLERGEN (Acidovoraxcitrulli) |
PF00544(Pec_lyase_C) | 5 | GLY A 50GLY A 49LEU A 183ALA A 91ASP A 89 | None | 1.21A | 3i5uA-4hwvA:undetectable | 3i5uA-4hwvA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i5u | CHIMERIC CEL6A (Humicolainsolens;Trichodermareesei;Chaetomiumthermophilum) |
PF01341(Glyco_hydro_6) | 5 | LEU A 439GLY A 398GLY A 397PRO A 396ALA A 112 | NoneNoneNoneEDO A 505 ( 4.7A)None | 1.22A | 3i5uA-4i5uA:undetectable | 3i5uA-4i5uA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igd | MANNAN-BINDINGLECTIN SERINEPROTEASE 1 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 5 | MET A 650LEU A 662GLY A 647GLY A 648TRP A 668 | NoneNoneNoneNoneGOL A 702 (-3.9A) | 1.21A | 3i5uA-4igdA:undetectable | 3i5uA-4igdA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ikv | DI-TRIPEPTIDE ABCTRANSPORTER(PERMEASE) (Geobacilluskaustophilus) |
PF00854(PTR2) | 5 | PHE A 185MET A 181GLY A 188LEU A 112ALA A 336 | None | 1.05A | 3i5uA-4ikvA:undetectable | 3i5uA-4ikvA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jru | THAUMATIN-LIKEPROTEIN (Vitis vinifera) |
PF00314(Thaumatin) | 5 | PHE A 27GLY A 65GLY A 66PRO A 43ASP A 117 | None | 1.17A | 3i5uA-4jruA:undetectable | 3i5uA-4jruA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4obs | ALPHA-L-IDURONIDASE (Homo sapiens) |
PF01229(Glyco_hydro_39) | 5 | LEU A 238GLY A 219GLY A 220LEU A 132ASP A 203 | None | 1.20A | 3i5uA-4obsA:undetectable | 3i5uA-4obsA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pgh | CAFFEIC ACIDO-METHYLTRANSFERASE (Sorghum bicolor) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 207GLY A 208LEU A 230ASP A 268TRP A 269 | SAM A 401 ( 3.9A)SAM A 401 ( 4.1A)SAM A 401 (-4.3A)NoneNone | 0.62A | 3i5uA-4pghA:25.5 | 3i5uA-4pghA:29.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0g | PROBABLEACETYL-/PROPIONYL-COA CARBOXYLASE (BETASUBUNIT) ACCD1 (Mycobacteriumtuberculosis) |
PF01039(Carboxyl_trans) | 5 | HIS A 42LEU A 49GLY A 33GLY A 34ALA A 104 | None | 1.18A | 3i5uA-4q0gA:undetectable | 3i5uA-4q0gA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ut1 | FLAGELLARHOOK-ASSOCIATEDPROTEIN (Burkholderiapseudomallei) |
PF06429(Flg_bbr_C) | 5 | LEU A 571GLY A 328GLY A 327PRO A 326ALA A 314 | None | 0.98A | 3i5uA-4ut1A:undetectable | 3i5uA-4ut1A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wj0 | CRISPR-ASSOCIATEDENDONUCLEASE CAS1 (Pyrococcushorikoshii) |
PF01867(Cas_Cas1) | 5 | LEU A 136GLY A 111GLY A 112PRO A 233ASP A 226 | None | 1.19A | 3i5uA-4wj0A:undetectable | 3i5uA-4wj0A:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzh | DIHYDROOROTATEDEHYDROGENASE (Leishmaniabraziliensis) |
PF01180(DHO_dh) | 5 | HIS A 261GLY A 222GLY A 223LEU A 64ALA A 230 | NoneFMN A 401 ( 3.9A)FMN A 401 (-3.3A)NoneNone | 1.19A | 3i5uA-4wzhA:undetectable | 3i5uA-4wzhA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yhj | G PROTEIN-COUPLEDRECEPTOR KINASE 4 (Homo sapiens) |
PF00069(Pkinase)PF00615(RGS) | 5 | LEU A 279GLY A 269GLY A 270LEU A 193ALA A 472 | NoneNoneNoneAN2 A 601 ( 4.2A)None | 1.04A | 3i5uA-4yhjA:undetectable | 3i5uA-4yhjA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yio | SUPEROXIDE DISMUTASE (Streptococcusthermophilus) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | HIS A 31GLY A 75GLY A 74LEU A 55ALA A 81 | None | 1.19A | 3i5uA-4yioA:undetectable | 3i5uA-4yioA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysw | XANTHINEDEHYDROGENASE/OXIDASE (Rattusnorvegicus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | MET A 833GLY A 838GLY A 837LEU A 905PRO A 906 | NoneNoneNoneNoneGOL A3008 ( 4.7A) | 1.09A | 3i5uA-4yswA:undetectable | 3i5uA-4yswA:14.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp7 | SAM-DEPENDENTMETHYLTRANSFERASE (Geobactersulfurreducens) |
PF13847(Methyltransf_31) | 5 | TRP A 241MET A 51LEU A 52GLY A 45ALA A 109 | NoneNoneNoneSAH A 301 (-3.6A)None | 1.19A | 3i5uA-5bp7A:14.1 | 3i5uA-5bp7A:25.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cvv | (ISO)EUGENOLO-METHYLTRANSFERASE (Clarkia breweri) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 6 | TRP A 166MET A 183GLY A 212LEU A 235ASP A 273TRP A 274 | SAH A 401 ( 3.6A)SAH A 401 ( 3.9A)SAH A 401 ( 4.2A)SAH A 401 (-4.3A)N7I A 402 ( 2.7A)None | 0.94A | 3i5uA-5cvvA:28.6 | 3i5uA-5cvvA:27.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cvv | (ISO)EUGENOLO-METHYLTRANSFERASE (Clarkia breweri) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 8 | TRP A 166PHE A 179MET A 183GLY A 212GLY A 213LEU A 235ASP A 273TRP A 274 | SAH A 401 ( 3.6A)NoneSAH A 401 ( 3.9A)SAH A 401 ( 4.2A)SAH A 401 ( 3.7A)SAH A 401 (-4.3A)N7I A 402 ( 2.7A)None | 0.45A | 3i5uA-5cvvA:28.6 | 3i5uA-5cvvA:27.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dxx | ARTEMISINIC ALDEHYDEDELTA(11(13))REDUCTASE (Artemisia annua) |
PF00724(Oxidored_FMN) | 5 | PHE A 313MET A 302LEU A 301GLY A 251LEU A 258 | None | 1.10A | 3i5uA-5dxxA:undetectable | 3i5uA-5dxxA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epe | SAM-DEPENDENTMETHYLTRANSFERASE (Thiobacillusdenitrificans) |
PF13847(Methyltransf_31) | 5 | TRP A 240MET A 50LEU A 51GLY A 44ALA A 108 | NoneNoneNoneSAH A 301 (-3.6A)None | 1.19A | 3i5uA-5epeA:12.5 | 3i5uA-5epeA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gms | ESTERASE (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | LEU A 36GLY A 77GLY A 76LEU A 150ASP A 106 | None | 0.94A | 3i5uA-5gmsA:3.4 | 3i5uA-5gmsA:26.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lkd | GLUTATHIONES-TRANSFERASEOMEGA-LIKE 2 (Saccharomycescerevisiae) |
PF13409(GST_N_2)PF13410(GST_C_2) | 5 | HIS A 341LEU A 44GLY A 103GLY A 104ALA A 130 | None | 1.22A | 3i5uA-5lkdA:undetectable | 3i5uA-5lkdA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t8y | EPOXYQUEUOSINEREDUCTASE (Bacillussubtilis) |
PF08331(DUF1730)PF13484(Fer4_16)PF13646(HEAT_2) | 5 | LEU A 169GLY A 150PRO A 161ALA A 147ASP A 181 | B12 A 503 (-4.1A)NoneNoneNoneNone | 1.20A | 3i5uA-5t8yA:undetectable | 3i5uA-5t8yA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vqj | EXO-BETA-1,4-XYLANASE (unidentified) |
no annotation | 5 | PHE A 18LEU A 5GLY A 51GLY A 52ASP A 191 | None | 1.13A | 3i5uA-5vqjA:undetectable | 3i5uA-5vqjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wyb | PROBABLE ENOYL-COAHYDRATASE/ISOMERASE (Pseudomonasaeruginosa) |
no annotation | 5 | PHE B 83LEU B 144GLY B 124GLY B 77ALA B 155 | MRD B 301 (-4.3A)NoneNoneMRD B 301 ( 4.8A)MRD B 301 (-4.2A) | 1.21A | 3i5uA-5wybB:undetectable | 3i5uA-5wybB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xoh | BERGAPTOLO-METHYLTRANSFERASE (Peucedanumpraeruptorum) |
no annotation | 6 | PHE A 171MET A 175GLY A 204GLY A 205LEU A 227TRP A 266 | 8B6 A 402 ( 4.9A)8B6 A 402 ( 3.6A)SAH A 401 ( 3.9A)SAH A 401 ( 3.7A)SAH A 401 (-4.1A)None | 0.34A | 3i5uA-5xohA:26.7 | 3i5uA-5xohA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yeq | KETOL-ACIDREDUCTOISOMERASE(NADP(+)) (Sulfolobusacidocaldarius) |
no annotation | 5 | LEU A 34GLY A 26GLY A 29LEU A 81ALA A 57 | SO4 A 504 (-4.6A)NoneNoneNoneNone | 1.06A | 3i5uA-5yeqA:4.4 | 3i5uA-5yeqA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yp3 | DIPEPTIDYLAMINOPEPTIDASE 4 (Pseudoxanthomonasmexicana) |
no annotation | 5 | MET A 621LEU A 622GLY A 615GLY A 616PRO A 638 | None | 1.13A | 3i5uA-5yp3A:undetectable | 3i5uA-5yp3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6az5 | ALPHA-AMYLASE ([Eubacterium]rectale) |
no annotation | 5 | LEU A 404GLY A 472GLY A 471ALA A 461TRP A 416 | None | 1.11A | 3i5uA-6az5A:undetectable | 3i5uA-6az5A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cyz | HOMOSERINE KINASE (Mycobacteroidesabscessus) |
no annotation | 5 | LEU A 221GLY A 23GLY A 25LEU A 236ALA A 231 | None | 1.06A | 3i5uA-6cyzA:undetectable | 3i5uA-6cyzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g0v | PROTEINASE A (Saccharomycescerevisiae) |
PF00026(Asp) | 4 | ASP A 87SER A 85PHE A 101SER A 90 | None | 1.47A | 3i5uA-1g0vA:undetectable | 3i5uA-1g0vA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d5l | DIPEPTIDYLAMINOPEPTIDASE IV,PUTATIVE (Porphyromonasgingivalis) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | ASP A 294SER A 347PHE A 343SER A 215 | None | 1.46A | 3i5uA-2d5lA:undetectable | 3i5uA-2d5lA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x9o | 15,16-DIHYDROBILIVERDIN-FERREDOXINOXIDOREDUCTASE (Synechococcussp. WH 8020) |
PF05996(Fe_bilin_red) | 4 | ASP A 205SER A 201PHE A 229SER A 220 | None | 1.29A | 3i5uA-2x9oA:undetectable | 3i5uA-2x9oA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y9e | MYOSIN-2 (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF02736(Myosin_N) | 4 | ASP X 454SER X 260PHE X 239SER X 236 | None | 1.43A | 3i5uA-2y9eX:0.2 | 3i5uA-2y9eX:16.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3i58 | O-METHYLTRANSFERASE (Streptomycescarzinostaticus) |
PF00891(Methyltransf_2) | 4 | ASP A 200SER A 227PHE A 228SER A 242 | SAH A 401 (-2.8A)SAH A 401 (-3.3A)SAH A 401 (-3.4A)SAH A 401 (-2.8A) | 0.14A | 3i5uA-3i58A:49.7 | 3i5uA-3i58A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ajt | PROTEIN Z-DEPENDENTPROTEASE INHIBITOR (Mus musculus) |
PF00079(Serpin) | 4 | ASP A 217SER A 89PHE A 86SER A 144 | None | 1.24A | 3i5uA-4ajtA:0.0 | 3i5uA-4ajtA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc5 | XYLULOSE KINASE (Homo sapiens) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | ASP A 215SER A 217PHE A 321SER A 284 | None | 1.47A | 3i5uA-4bc5A:0.2 | 3i5uA-4bc5A:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4buj | ANTIVIRAL PROTEINSKI8 (Saccharomycescerevisiae) |
PF00400(WD40) | 4 | ASP C 42SER C 27PHE C 28SER C 57 | None | 1.27A | 3i5uA-4bujC:0.0 | 3i5uA-4bujC:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gq2 | NUCLEOPORIN NUP120 (Schizosaccharomycespombe) |
PF11715(Nup160) | 4 | ASP M 727SER M 691PHE M 688SER M 799 | None | 1.49A | 3i5uA-4gq2M:0.0 | 3i5uA-4gq2M:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf7 | NUP188 (Thermothelomycesthermophila) |
PF10487(Nup188) | 4 | ASP A 39SER A 43PHE A1119SER A1070 | None | 1.23A | 3i5uA-4kf7A:1.1 | 3i5uA-4kf7A:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oan | TRAP DICARBOXYLATETRANSPORTER DCTPSUBUNIT (Rhodopseudomonaspalustris) |
PF03480(DctP) | 4 | ASP A 80SER A 98PHE A 245SER A 74 | X2X A 402 ( 4.8A)X2X A 402 ( 4.5A)X2X A 402 (-4.7A)None | 1.48A | 3i5uA-4oanA:undetectable | 3i5uA-4oanA:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r2b | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Ochrobactrumanthropi) |
PF01547(SBP_bac_1) | 4 | ASP A 245SER A 248PHE A 247SER A 241 | None | 1.45A | 3i5uA-4r2bA:undetectable | 3i5uA-4r2bA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yis | MEGANUCLEASE I-CPAMI (Cryphonectriaparasitica) |
PF00961(LAGLIDADG_1) | 4 | ASP A 177SER A 175PHE A 14SER A 20 | CA A 301 ( 2.3A)NoneNoneNone | 1.38A | 3i5uA-4yisA:undetectable | 3i5uA-4yisA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b0s | LIN0857 PROTEIN (Listeriainnocua) |
PF04041(Glyco_hydro_130) | 4 | ASP A 80SER A 75PHE A 76SER A 93 | None | 1.49A | 3i5uA-5b0sA:undetectable | 3i5uA-5b0sA:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f2o | FATTY ACIDO-METHYLTRANSFERASE (Mycobacteriummarinum) |
PF03492(Methyltransf_7) | 4 | ASP A 98SER A 133PHE A 134SER A 150 | SAH A 400 (-2.8A)SAH A 400 (-3.0A)SAH A 400 (-3.3A)SAH A 400 (-2.7A) | 0.80A | 3i5uA-5f2oA:13.7 | 3i5uA-5f2oA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw7 | GLUCOSIDASE YGJK (Escherichiacoli) |
PF01204(Trehalase) | 4 | ASP A 136SER A 214PHE A 212SER A 69 | None | 1.39A | 3i5uA-5gw7A:0.0 | 3i5uA-5gw7A:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jod | PROPLASMEPSIN IV (Plasmodiumfalciparum) |
PF00026(Asp) | 4 | ASP A 89SER A 87PHE A 102SER A 92 | None | 1.45A | 3i5uA-5jodA:undetectable | 3i5uA-5jodA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux4 | CATHEPSIN D (Rattusnorvegicus) |
no annotation | 4 | ASP A 90SER A 88PHE A 110SER A 93 | None | 1.49A | 3i5uA-5ux4A:undetectable | 3i5uA-5ux4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wgx | FLAVIN-DEPENDENTHALOGENASE (Malbrancheaaurantiaca) |
PF04820(Trp_halogenase) | 4 | ASP A 578SER A 576PHE A 577SER A 558 | None | 1.44A | 3i5uA-5wgxA:2.3 | 3i5uA-5wgxA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wmb | DNA REPAIR PROTEINREV1 (Saccharomycescerevisiae) |
no annotation | 4 | ASP A 467SER A 445PHE A 448SER A 507 | MG A 801 (-2.2A)EDO A 811 (-3.0A)NoneNone | 1.23A | 3i5uA-5wmbA:undetectable | 3i5uA-5wmbA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b2w | PUTATIVEPEPTIDYL-ARGININEDEIMINASE FAMILYPROTEIN (Campylobacterjejuni) |
no annotation | 4 | ASP A 77SER A 110PHE A 101SER A 315 | AG2 A 401 ( 4.7A)NoneNoneAG2 A 401 (-3.1A) | 1.38A | 3i5uA-6b2wA:undetectable | 3i5uA-6b2wA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8s | LOGANIC ACIDO-METHYLTRANSFERASE (Catharanthusroseus) |
no annotation | 4 | ASP A 114SER A 141PHE A 142SER A 158 | SAH A 401 (-2.8A)SAH A 401 (-3.1A)SAH A 401 (-3.3A)SAH A 401 (-3.6A) | 0.88A | 3i5uA-6c8sA:13.7 | 3i5uA-6c8sA:undetectable |