SIMILAR PATTERNS OF AMINO ACIDS FOR 3HZN_D_ACTD229

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		4 ASP A 204
GLY A 205
LYS A 203
GLU A 251
 None
 1.18A 3hznD-1a3gA:
0.0		 3hznD-1a3gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhe POLYGALACTURONASE

(Pectobacterium
carotovorum) 		PF00295
(Glyco_hydro_28) 		4 ASP A 284
GLY A 319
LYS A 317
GLU A 318
 None
 1.47A 3hznD-1bheA:
0.0		 3hznD-1bheA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 ASP A 708
GLY A 707
LYS A 709
GLU A 706
 None
 1.48A 3hznD-1c4kA:
0.0		 3hznD-1c4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		4 ASP A 146
GLY A 169
LYS A 166
GLU A 167
 None
 1.23A 3hznD-1dl5A:
0.0		 3hznD-1dl5A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEASE A INHIBITOR
3

(Saccharomyces
cerevisiae) 		PF10466
(Inhibitor_I34) 		4 ASP B  22
GLY B  21
LYS B  18
GLU B  17
 None
 1.35A 3hznD-1g0vB:
undetectable		 3hznD-1g0vB:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg3 ERYTHROID MEMBRANE
PROTEIN 4.1R

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ASP A  57
GLY A  23
LYS A  60
GLU A  61
 None
 1.25A 3hznD-1gg3A:
undetectable		 3hznD-1gg3A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i51 CASPASE-7 SUBUNIT
P20
CASPASE-7 SUBUNIT
P11

(Homo sapiens;
Homo sapiens) 		PF00656
(Peptidase_C14)
PF00656
(Peptidase_C14) 		4 ASP A 193
GLY A 194
LYS B 285
GLU B 274
 None
 1.06A 3hznD-1i51A:
undetectable		 3hznD-1i51A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv4 MAJOR URINARY
PROTEIN 2

(Mus musculus) 		PF00061
(Lipocalin) 		4 ASP A 110
GLY A 111
LYS A 109
GLU A 108
 None
 1.42A 3hznD-1jv4A:
undetectable		 3hznD-1jv4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbz FRUCTOSE
1,6-BISPHOSPHATASE/I
NOSITOL
MONOPHOSPHATASE

(Archaeoglobus
fulgidus) 		PF00459
(Inositol_P) 		4 ASP A  32
GLY A  34
LYS A  43
GLU A  68
 None
None
None
CA  A 292 ( 4.4A)
 1.33A 3hznD-1lbzA:
undetectable		 3hznD-1lbzA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt0 HEMOLYSIN SECRETION
ATP-BINDING PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran) 		4 ASP A 486
GLY A 679
LYS A 680
GLU A 677
 None
 1.44A 3hznD-1mt0A:
undetectable		 3hznD-1mt0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		4 ASP A 128
GLY A 155
LYS A 152
GLU A 153
 None
 1.24A 3hznD-1nt2A:
undetectable		 3hznD-1nt2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbf 231AA LONG
HYPOTHETICAL
PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01135
(PCMT) 		4 ASP A 136
GLY A 159
LYS A 156
GLU A 157
 None
 1.42A 3hznD-1vbfA:
undetectable		 3hznD-1vbfA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ASP A 353
GLY A 354
LYS A 352
GLU A 351
 None
 1.11A 3hznD-1vkzA:
undetectable		 3hznD-1vkzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A  73
GLY A  75
LYS A  68
GLU A  50
 None
 0.91A 3hznD-1vzoA:
undetectable		 3hznD-1vzoA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF13649
(Methyltransf_25) 		4 ASP A 104
GLY A 136
LYS A 134
GLU A 135
 None
 1.41A 3hznD-1y8cA:
undetectable		 3hznD-1y8cA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF13649
(Methyltransf_25) 		4 ASP A 104
GLY A 137
LYS A 134
GLU A 135
 None
 1.42A 3hznD-1y8cA:
undetectable		 3hznD-1y8cA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9l LIPOPROTEIN MXIM

(Shigella
flexneri) 		PF11441
(MxiM) 		4 ASP A 131
GLY A 132
LYS A 130
GLU A 129
 None
 1.07A 3hznD-1y9lA:
undetectable		 3hznD-1y9lA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 ASP A 283
GLY A 288
LYS A 289
GLU A 290
 None
 1.33A 3hznD-1ygpA:
undetectable		 3hznD-1ygpA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yww HYPOTHETICAL PROTEIN
PA4738

(Pseudomonas
aeruginosa) 		PF05532
(CsbD) 		4 ASP A  26
GLY A  15
LYS A  18
GLU A  19
 None
 1.42A 3hznD-1ywwA:
undetectable		 3hznD-1ywwA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF01327
(Pep_deformylase) 		4 ASP A 159
GLY A 160
LYS A  17
GLU A  16
 None
 1.21A 3hznD-1zy1A:
undetectable		 3hznD-1zy1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0a DER F 13

(Dermatophagoides
farinae) 		PF00061
(Lipocalin) 		4 ASP A  99
GLY A  98
LYS A 100
GLU A 101
 None
 1.46A 3hznD-2a0aA:
undetectable		 3hznD-2a0aA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bh5 CYTOCHROME C-550

(Paracoccus
versutus) 		no annotation 4 ASP X   4
GLY X   8
LYS X   7
GLU X  11
 None
 1.42A 3hznD-2bh5X:
undetectable		 3hznD-2bh5X:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ASP A 244
GLY A 245
LYS A 247
GLU A 246
 None
 1.16A 3hznD-2cvzA:
undetectable		 3hznD-2cvzA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi6 UPF0107 PROTEIN
AF0055

(Archaeoglobus
fulgidus) 		PF01989
(DUF126) 		4 ASP A  31
GLY A  29
LYS A  38
GLU A  39
 None
 1.34A 3hznD-2hi6A:
undetectable		 3hznD-2hi6A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2il5 HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF08327
(AHSA1) 		4 ASP A  53
GLY A  57
LYS A  55
GLU A  56
 None
 1.46A 3hznD-2il5A:
undetectable		 3hznD-2il5A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdi UBIQUITIN, VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN 27 FUSION
PROTEIN

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin)
PF02809
(UIM) 		4 ASP A  41
GLY A  44
LYS A  42
GLU A  43
 None
 1.31A 3hznD-2kdiA:
undetectable		 3hznD-2kdiA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6m PROTEIN DICER

(Schizosaccharomyces
pombe) 		no annotation 4 ASP A  15
GLY A  17
LYS A  14
GLU A  19
 None
 1.08A 3hznD-2l6mA:
undetectable		 3hznD-2l6mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2k FERREDOXIN

(Mycolicibacterium
smegmatis) 		PF00037
(Fer4) 		4 ASP A  41
GLY A  43
LYS A   1
GLU A  46
 None
F3S  A 107 (-3.6A)
None
None
 1.32A 3hznD-2v2kA:
undetectable		 3hznD-2v2kA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 ASP A 527
GLY A 525
LYS A 522
GLU A 524
 None
 1.48A 3hznD-2xtlA:
undetectable		 3hznD-2xtlA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 ASP A 235
GLY A 257
LYS A 322
GLU A 321
 ATP  A 508 (-3.3A)
None
None
None
 1.33A 3hznD-2y27A:
undetectable		 3hznD-2y27A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		4 ASP A 376
GLY A  23
LYS A 375
GLU A  24
 None
 1.43A 3hznD-2y4fA:
0.8		 3hznD-2y4fA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Geobacillus
kaustophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ASP A 313
GLY A 314
LYS A 315
GLU A 316
 None
 1.49A 3hznD-2ys6A:
undetectable		 3hznD-2ys6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A  86
GLY A  88
LYS A  81
GLU A  63
 None
 0.92A 3hznD-2z7rA:
undetectable		 3hznD-2z7rA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyt SORTING NEXIN-9

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		4 ASP A 410
GLY A 412
LYS A 414
GLU A 415
 None
 1.02A 3hznD-3dytA:
undetectable		 3hznD-3dytA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egj N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		4 ASP A  26
GLY A  25
LYS A  27
GLU A  29
 None
 1.35A 3hznD-3egjA:
undetectable		 3hznD-3egjA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE

(Legionella
pneumophila) 		PF13523
(Acetyltransf_8) 		4 ASP A  89
GLY A  90
LYS A  83
GLU A  82
 None
 1.28A 3hznD-3f5bA:
undetectable		 3hznD-3f5bA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 ASP A 401
GLY A 400
LYS A 402
GLU A 399
 None
 1.31A 3hznD-3gdbA:
undetectable		 3hznD-3gdbA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASP A  47
GLY A  46
LYS A  43
GLU A  42
 None
 1.29A 3hznD-3h3jA:
undetectable		 3hznD-3h3jA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irb UNCHARACTERIZED
PROTEIN FROM DUF35
FAMILY

(Sulfolobus
solfataricus) 		PF01796
(OB_aCoA_assoc)
PF12172
(DUF35_N) 		4 ASP A 144
GLY A 122
LYS A 142
GLU A 121
 None
 1.17A 3hznD-3irbA:
undetectable		 3hznD-3irbA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASP A  46
GLY A  45
LYS A  42
GLU A  41
 None
 1.48A 3hznD-3pqdA:
undetectable		 3hznD-3pqdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tq7 MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF03271
(EB1) 		4 ASP B 217
GLY B 218
LYS B 221
GLU B 222
 None
 1.41A 3hznD-3tq7B:
undetectable		 3hznD-3tq7B:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwh (R)-AMINE
TRANSAMINASE

(Arthrobacter
sp. KNK168) 		PF01063
(Aminotran_4) 		4 ASP A 232
GLY A 233
LYS A 231
GLU A 277
 None
 1.41A 3hznD-3wwhA:
undetectable		 3hznD-3wwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zit THIOREDOXIN

(Bacillus cereus) 		PF00462
(Glutaredoxin) 		4 ASP A  59
GLY A  60
LYS A   3
GLU A   5
 None
 1.44A 3hznD-3zitA:
undetectable		 3hznD-3zitA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce5 AT-OMEGATA

(Aspergillus
terreus) 		PF01063
(Aminotran_4) 		4 ASP A 224
GLY A 225
LYS A 223
GLU A 269
 None
 1.35A 3hznD-4ce5A:
undetectable		 3hznD-4ce5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmf AMINOTRANSFERASE

([Nectria]
haematococca) 		PF01063
(Aminotran_4) 		4 ASP A 223
GLY A 224
LYS A 222
GLU A 268
 None
 1.35A 3hznD-4cmfA:
undetectable		 3hznD-4cmfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 213
GLY A 260
LYS A 261
GLU A 259
 None
 1.23A 3hznD-4h53A:
undetectable		 3hznD-4h53A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 ASP A 228
GLY A 248
LYS A 245
GLU A 246
 EDO  A 403 (-3.0A)
None
EDO  A 403 (-2.9A)
None
 1.43A 3hznD-4idaA:
undetectable		 3hznD-4idaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxu PUTATIVE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF01063
(Aminotran_4) 		4 ASP A 202
GLY A 203
LYS A 201
GLU A 249
 None
 1.37A 3hznD-4jxuA:
undetectable		 3hznD-4jxuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2a HALOALKANE
DEHALOGENASE

(Bradyrhizobium
elkanii) 		PF00561
(Abhydrolase_1) 		4 ASP A   6
GLY A  25
LYS A   6
GLU A  23
 None
 1.02A 3hznD-4k2aA:
undetectable		 3hznD-4k2aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		4 ASP A  61
GLY A  62
LYS A  60
GLU A  59
 None
 1.16A 3hznD-4l05A:
undetectable		 3hznD-4l05A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ne4 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(PROLINE/GLYCINE/BET
AINE)

(Agrobacterium
fabrum) 		PF04069
(OpuAC) 		4 ASP A  81
GLY A  85
LYS A  84
GLU A  88
 None
 1.40A 3hznD-4ne4A:
undetectable		 3hznD-4ne4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0w DNA REPAIR PROTEIN
RAD2

(Saccharomyces
cerevisiae) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ASP A 900
GLY A 897
LYS A 903
GLU A 907
 None
 1.27A 3hznD-4q0wA:
undetectable		 3hznD-4q0wA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		4 ASP A 150
GLY A 182
LYS A 179
GLU A 180
 None
 1.43A 3hznD-4qppA:
undetectable		 3hznD-4qppA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN

(Dictyostelium
discoideum) 		no annotation 4 ASP A 229
GLY A 231
LYS A 234
GLU A 235
 None
 1.04A 3hznD-4x3nA:
undetectable		 3hznD-4x3nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		4 ASP A  73
GLY A  72
LYS A  69
GLU A  68
 None
 1.35A 3hznD-4xiaA:
undetectable		 3hznD-4xiaA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr7 SENSOR HISTIDINE
KINASE RESE

(Bacillus
subtilis) 		no annotation 4 ASP A  85
GLY A 152
LYS A 150
GLU A 146
 None
 1.15A 3hznD-4zr7A:
undetectable		 3hznD-4zr7A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		4 ASP A 553
GLY A 570
LYS A 552
GLU A 576
 None
None
PEG  A 703 (-3.0A)
None
 1.36A 3hznD-5cxwA:
undetectable		 3hznD-5cxwA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ize RNA-DIRECTED RNA
POLYMERASE L

(Hantaan
orthohantavirus) 		no annotation 4 ASP A 116
GLY A 120
LYS A 119
GLU A 123
 None
 1.35A 3hznD-5izeA:
undetectable		 3hznD-5izeA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvv BETA-1,3-GLUCOSYLTRA
NSFERASE

(Paecilomyces
sp.
'thermophila') 		no annotation 4 ASP B 193
GLY B 234
LYS B 235
GLU B 236
 None
 1.28A 3hznD-5jvvB:
undetectable		 3hznD-5jvvB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 ASP A 612
GLY A 610
LYS A 619
GLU A 620
 None
 1.36A 3hznD-5lq3A:
2.5		 3hznD-5lq3A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msl ANTI-SIGMA-F FACTOR
FIN

(Bacillus
subtilis) 		PF10955
(DUF2757) 		4 ASP A  48
GLY A  47
LYS A  44
GLU A  45
 None
 1.28A 3hznD-5mslA:
undetectable		 3hznD-5mslA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o98 ALCOHOL
DEHYDROGENASE 1

(Catharanthus
roseus) 		no annotation 4 ASP A  47
GLY A  45
LYS A  43
GLU A  42
 None
 1.35A 3hznD-5o98A:
undetectable		 3hznD-5o98A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3b GLYCOSIDE HYDROLASE

(Bacteroides
plebeius) 		no annotation 4 ASP A 352
GLY A 349
LYS A 348
GLU A 347
 None
 1.48A 3hznD-5t3bA:
undetectable		 3hznD-5t3bA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ASP H  33
GLY H  95
LYS H  97
GLU H 103
 None
 1.46A 3hznD-5uy3H:
undetectable		 3hznD-5uy3H:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 4 ASP A 213
GLY A 260
LYS A 261
GLU A 259
 None
 1.15A 3hznD-6br6A:
undetectable		 3hznD-6br6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 4 ASP A 144
GLY A 145
LYS A 143
GLU A 142
 None
 1.28A 3hznD-6dllA:
undetectable		 3hznD-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASP A 432
GLY A 395
LYS A 454
GLU A 457
 None
 1.30A 3hznD-6f91A:
undetectable		 3hznD-6f91A:
undetectable