SIMILAR PATTERNS OF AMINO ACIDS FOR 3HY7_A_097A801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		5 LEU A 120
GLU A 121
HIS A 108
HIS A 206
ILE A 353
 None
 1.29A 3hy7A-1a59A:
undetectable		 3hy7A-1a59A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 800 (-3.2A)
ZN  A 800 ( 4.7A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.3A)
 0.27A 3hy7A-1budA:
25.3		 3hy7A-1budA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eak 72 KDA TYPE IV
COLLAGENASE

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A 191
HIS A 403
HIS A 407
HIS A 413
ILE A 424
 None
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
None
 0.90A 3hy7A-1eakA:
10.2		 3hy7A-1eakA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb6 NEUTRAL PROTEASE II

(Aspergillus
oryzae) 		PF02102
(Peptidase_M35) 		5 LEU A  90
THR A 125
HIS A 128
GLU A 129
HIS A 132
 None
None
ZN  A 178 (-3.3A)
ZN  A 178 ( 4.0A)
ZN  A 178 (-3.3A)
 0.46A 3hy7A-1eb6A:
5.0		 3hy7A-1eb6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)

(Sus scrofa) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		5 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 HTA  A 900 (-3.6A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.43A 3hy7A-1fblA:
10.2		 3hy7A-1fblA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 THR P 166
HIS P 169
GLU P 170
HIS P 173
HIS P 179
 None
ZN  P 600 (-3.4A)
ZN  P 600 ( 4.0A)
ZN  P 600 (-3.4A)
ZN  P 600 (-3.4A)
 0.31A 3hy7A-1h71P:
4.2		 3hy7A-1h71P:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 ASP A 200
GLU A 329
HIS A 344
HIS A 224
LEU A 219
 None
None
CU  A 666 (-3.1A)
CU  A 665 (-3.5A)
None
 1.19A 3hy7A-1hcyA:
undetectable		 3hy7A-1hcyA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfs STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 L04  A 256 ( 3.7A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.40A 3hy7A-1hfsA:
10.7		 3hy7A-1hfsA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		6 LEU A 108
HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 170
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 4.5A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
None
 0.85A 3hy7A-1htdA:
26.0		 3hy7A-1htdA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		6 LEU A 108
THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 4.5A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
 0.42A 3hy7A-1htdA:
26.0		 3hy7A-1htdA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv5 STROMELYSIN 3

(Mus musculus) 		PF00413
(Peptidase_M10) 		5 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 (-3.9A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.47A 3hy7A-1hv5A:
10.2		 3hy7A-1hv5A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iab ASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		5 THR A  89
HIS A  92
GLU A  93
HIS A  96
HIS A 102
 None
CO  A 999 (-3.2A)
CO  A 999 ( 4.3A)
CO  A 999 (-3.3A)
CO  A 999 (-3.1A)
 0.19A 3hy7A-1iabA:
8.0		 3hy7A-1iabA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 THR A 141
HIS A 144
GLU A 145
HIS A 148
HIS A 154
 None
CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.21A 3hy7A-1kugA:
27.1		 3hy7A-1kugA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 None
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.38A 3hy7A-1l6jA:
9.4		 3hy7A-1l6jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		5 LEU A 224
HIS A 264
GLU A 265
HIS A 268
HIS A 334
 None
ZN  A 578 ( 3.5A)
ZN  A 578 ( 4.1A)
ZN  A 578 ( 3.4A)
ZN  A 578 ( 3.4A)
 0.92A 3hy7A-1lmlA:
6.8		 3hy7A-1lmlA:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		6 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 170
 None
ZN  A 400 (-3.2A)
ZN  A 400 ( 4.4A)
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
None
 0.70A 3hy7A-1nd1A:
25.9		 3hy7A-1nd1A:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qib 72 KDA TYPE IV
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A 201
GLU A 202
HIS A 205
HIS A 211
ILE A 222
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
None
 0.76A 3hy7A-1qibA:
10.4		 3hy7A-1qibA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qib 72 KDA TYPE IV
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 None
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
 0.35A 3hy7A-1qibA:
10.4		 3hy7A-1qibA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs2 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		5 ASP A 456
LEU A 406
THR A 387
ILE A 403
LEU A 404
 None
 1.34A 3hy7A-1qs2A:
undetectable		 3hy7A-1qs2A:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 168
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
None
 0.67A 3hy7A-1quaA:
26.5		 3hy7A-1quaA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
 0.29A 3hy7A-1quaA:
26.5		 3hy7A-1quaA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r55 ADAM 33

(Homo sapiens) 		PF01421
(Reprolysin) 		5 THR A 342
HIS A 345
GLU A 346
HIS A 349
HIS A 355
 097  A 518 (-3.5A)
ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
 0.24A 3hy7A-1r55A:
26.0		 3hy7A-1r55A:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.34A 3hy7A-1rm8A:
10.7		 3hy7A-1rm8A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 None
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.40A 3hy7A-1slmA:
10.3		 3hy7A-1slmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		5 ASP A 485
LEU A 445
THR A 339
HIS A 370
LEU A 441
 None
 1.09A 3hy7A-1u6zA:
undetectable		 3hy7A-1u6zA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 999 (-3.5A)
ZN  A 999 ( 4.2A)
ZN  A 999 (-3.5A)
ZN  A 999 (-3.4A)
 0.22A 3hy7A-1wniA:
26.8		 3hy7A-1wniA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		5 LEU A 189
HIS A 215
HIS A 194
HIS A 216
LEU A 222
 None
None
CU  A 401 ( 3.2A)
CU  A 401 ( 3.4A)
None
 1.16A 3hy7A-1wx4A:
undetectable		 3hy7A-1wx4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x42 HYPOTHETICAL PROTEIN
PH0459

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 ASP A 123
HIS A  95
GLU A  19
HIS A  91
LEU A 129
 None
 1.24A 3hy7A-1x42A:
undetectable		 3hy7A-1x42A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y13 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
falciparum) 		PF01242
(PTPS) 		5 THR A  39
HIS A  41
GLU A  38
HIS A  29
HIS A  43
 None
ZN  A 174 ( 3.3A)
BIO  A 175 (-2.6A)
ZN  A 174 ( 3.5A)
ZN  A 174 ( 3.4A)
 1.21A 3hy7A-1y13A:
undetectable		 3hy7A-1y13A:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 169
 ZN  A 999 (-3.3A)
ZN  A 999 ( 4.9A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
None
 0.84A 3hy7A-1yp1A:
26.5		 3hy7A-1yp1A:
30.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq7 HYPOTHETICAL PROTEIN
MM0484

(Methanosarcina
mazei) 		PF01871
(AMMECR1) 		5 LEU A 130
THR A 160
HIS A 159
ILE A 154
LEU A 157
 None
 1.30A 3hy7A-1zq7A:
undetectable		 3hy7A-1zq7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0s 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
vivax) 		PF01242
(PTPS) 		5 THR A  46
HIS A  48
GLU A  45
HIS A  36
HIS A  50
 None
ZN  A 281 (-3.3A)
BIO  A 282 (-3.1A)
ZN  A 281 ( 3.5A)
ZN  A 281 (-3.3A)
 1.19A 3hy7A-2a0sA:
undetectable		 3hy7A-2a0sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwl MANGANESE-FREE
PSEUDOCATALASE

(Thermus
thermophilus) 		PF05067
(Mn_catalase) 		5 LEU A  40
HIS A  73
GLU A  36
HIS A 188
LEU A  71
 None
 1.33A 3hy7A-2cwlA:
undetectable		 3hy7A-2cwlA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 LEU A 111
HIS A 145
GLU A 146
HIS A 149
HIS A 155
 GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.31A 3hy7A-2e3xA:
25.4		 3hy7A-2e3xA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejq HYPOTHETICAL PROTEIN
TTHA0227

(Thermus
thermophilus) 		PF06262
(Zincin_1) 		5 LEU A  46
THR A  92
HIS A  95
GLU A  96
HIS A  99
 None
 0.59A 3hy7A-2ejqA:
2.7		 3hy7A-2ejqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 HIS A 335
GLU A 336
HIS A 339
HIS A 345
LEU A 363
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
None
 0.57A 3hy7A-2erqA:
26.7		 3hy7A-2erqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6k METAL-DEPENDENT
HYDROLASE

(Lactobacillus
plantarum) 		PF04909
(Amidohydro_2) 		5 ASP A  79
LEU A  54
THR A   8
HIS A   9
HIS A 154
 None
None
None
MN  A 402 (-3.5A)
MN  A 402 (-3.3A)
 1.29A 3hy7A-2f6kA:
undetectable		 3hy7A-2f6kA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens) 		PF13688
(Reprolysin_5) 		6 LEU A 348
HIS A 405
GLU A 406
HIS A 409
HIS A 415
ILE A 438
 541  A   1 (-4.4A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
None
 0.43A 3hy7A-2fv5A:
20.0		 3hy7A-2fv5A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsd MATRIX
METALLOPROTEINASE-20

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 189
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 NGH  A 277 (-4.1A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
 0.67A 3hy7A-2jsdA:
10.5		 3hy7A-2jsdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy4 NEUTROPHIL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 160
HIS A 197
GLU A 198
HIS A 201
HIS A 207
 None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
 0.33A 3hy7A-2oy4A:
10.6		 3hy7A-2oy4A:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		6 ASP A 377
LEU A 379
THR A 407
GLU A 411
HIS A 414
HIS A 420
 BAT  A 559 (-3.7A)
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.69A 3hy7A-2rjqA:
36.9		 3hy7A-2rjqA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		7 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
ILE A 442
 BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.3A)
 0.46A 3hy7A-2rjqA:
36.9		 3hy7A-2rjqA:
99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6c MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 TQI  A1269 ( 3.8A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.46A 3hy7A-2y6cA:
9.4		 3hy7A-2y6cA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		5 LEU A 284
HIS A 345
GLU A 282
ILE A 290
LEU A 288
 None
None
None
HEM  A 413 ( 4.9A)
None
 1.29A 3hy7A-2zbzA:
undetectable		 3hy7A-2zbzA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		5 ASP A 150
HIS A 103
GLU A 165
HIS A  40
ILE A 152
 None
ZN  A 251 ( 3.2A)
PO4  A 261 (-3.2A)
ZN  A 251 ( 3.2A)
None
 1.12A 3hy7A-3a9lA:
undetectable		 3hy7A-3a9lA:
18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		5 LEU A 330
THR A 358
HIS A 361
HIS A 365
HIS A 371
 None
None
ZN  A   1 (-3.0A)
ZN  A   1 (-3.3A)
ZN  A   1 (-3.2A)
 0.46A 3hy7A-3b2zA:
33.6		 3hy7A-3b2zA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		8 ASP A 377
LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
ILE A 442
 None
294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
None
 0.52A 3hy7A-3b8zA:
41.6		 3hy7A-3b8zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		7 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
ILE A 442
LEU A 443
 294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
None
294  A 801 (-4.1A)
 0.91A 3hy7A-3b8zA:
41.6		 3hy7A-3b8zA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba0 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		6 LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 None
None
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
 0.77A 3hy7A-3ba0A:
9.9		 3hy7A-3ba0A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 HIS A 140
GLU A 141
HIS A 144
HIS A 150
LEU A 168
 ZN  A 302 (-3.3A)
ZN  A 302 ( 4.6A)
ZN  A 302 (-3.3A)
ZN  A 302 (-3.2A)
None
 0.75A 3hy7A-3gboA:
26.2		 3hy7A-3gboA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 THR A 137
HIS A 140
GLU A 141
HIS A 144
HIS A 150
 None
ZN  A 302 (-3.3A)
ZN  A 302 ( 4.6A)
ZN  A 302 (-3.3A)
ZN  A 302 (-3.2A)
 0.22A 3hy7A-3gboA:
26.2		 3hy7A-3gboA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyg UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		PF01242
(PTPS) 		5 THR A 169
HIS A  40
HIS A  38
HIS A  15
ILE A 142
 None
ZN  A 200 (-3.4A)
ZN  A 200 (-3.3A)
ZN  A 200 (-3.5A)
None
 1.06A 3hy7A-3jygA:
undetectable		 3hy7A-3jygA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 THR A 338
HIS A 341
GLU A 342
HIS A 345
HIS A 351
 None
ZN  A 704 (-3.1A)
ZN  A 704 ( 4.5A)
ZN  A 704 (-3.3A)
ZN  A 704 (-3.2A)
 0.29A 3hy7A-3k7nA:
26.4		 3hy7A-3k7nA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		6 LEU A 188
THR A 225
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.47A 3hy7A-3lunA:
14.7		 3hy7A-3lunA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2x COLLAGENASE 3

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A1185
HIS A1222
GLU A1223
HIS A1226
HIS A1232
 3O2  A1801 (-4.0A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
 0.40A 3hy7A-3o2xA:
10.3		 3hy7A-3o2xA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2x COLLAGENASE 3

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A1185
HIS A1222
GLU A1223
HIS A1226
ILE A1243
 3O2  A1801 (-4.0A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
None
 0.73A 3hy7A-3o2xA:
10.3		 3hy7A-3o2xA:
25.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		8 ASP A 116
LEU A 118
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
LEU A 182
 None
QHF  A   1 (-4.5A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
QHF  A   1 (-4.7A)
 0.48A 3hy7A-3q2hA:
35.2		 3hy7A-3q2hA:
57.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf0 EXOPOLYPHOSPHATASE

(Yersinia pestis) 		no annotation 5 ASP A 178
LEU A 138
THR A  32
HIS A  63
LEU A 134
 None
 1.15A 3hy7A-3rf0A:
undetectable		 3hy7A-3rf0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shi INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.35A 3hy7A-3shiA:
10.7		 3hy7A-3shiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v96 STROMELYSIN-2

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU B 180
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 None
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.36A 3hy7A-3v96B:
10.8		 3hy7A-3v96B:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		5 THR A 173
HIS A 176
GLU A 177
HIS A 180
HIS A 186
 None
ZN  A 500 (-3.2A)
ZN  A 500 ( 4.2A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.2A)
 0.24A 3hy7A-3vi1A:
7.3		 3hy7A-3vi1A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 170
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
FLX  A 400 (-4.0A)
 0.67A 3hy7A-4aigA:
26.2		 3hy7A-4aigA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 LEU A 170
THR A 139
HIS A 142
HIS A 146
HIS A 152
 FLX  A 400 (-4.0A)
FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 1.21A 3hy7A-4aigA:
26.2		 3hy7A-4aigA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.32A 3hy7A-4aigA:
26.2		 3hy7A-4aigA:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8

(Homo sapiens) 		PF01421
(Reprolysin) 		5 THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
 BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.37A 3hy7A-4dd8A:
26.2		 3hy7A-4dd8A:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		5 ASP A  89
THR A 223
GLU A 222
HIS A 219
HIS A 192
 None
None
NOS  A 501 (-3.0A)
NOS  A 501 (-3.5A)
NOS  A 501 (-4.0A)
 1.14A 3hy7A-4f0sA:
undetectable		 3hy7A-4f0sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr8 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		6 LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-3.6A)
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.45A 3hy7A-4gr8A:
11.2		 3hy7A-4gr8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA

(Homo sapiens) 		PF00629
(MAM)
PF01400
(Astacin) 		5 THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
 None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.34A 3hy7A-4gwnA:
7.8		 3hy7A-4gwnA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4in9 KARILYSIN PROTEASE

(Tannerella
forsythia) 		PF00413
(Peptidase_M10) 		5 LEU A 115
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.57A 3hy7A-4in9A:
10.4		 3hy7A-4in9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 THR A 141
HIS A 144
GLU A 145
HIS A 148
HIS A 154
 None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
 0.17A 3hy7A-4j4mA:
27.0		 3hy7A-4j4mA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l63 ECXA

(Escherichia
coli) 		PF16313
(DUF4953) 		6 LEU A 122
THR A 176
HIS A 179
GLU A 180
HIS A 183
HIS A 189
 None
None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.34A 3hy7A-4l63A:
7.1		 3hy7A-4l63A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 THR B 268
HIS B 255
HIS B 251
HIS B 282
ILE B 278
 None
CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
None
None
 1.34A 3hy7A-4ouaB:
undetectable		 3hy7A-4ouaB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 THR A 268
HIS A 255
HIS A 251
HIS A 282
ILE A 278
 None
CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.0A)
None
 1.33A 3hy7A-4ouaA:
undetectable		 3hy7A-4ouaA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1j POLYKETIDE
BIOSYNTHESIS
ENOYL-COA ISOMERASE
PKSI

(Bacillus
subtilis) 		PF00378
(ECH_1) 		5 LEU A  33
HIS A   3
GLU A  32
ILE A  38
LEU A  37
 None
 1.20A 3hy7A-4q1jA:
undetectable		 3hy7A-4q1jA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 170
 ZN  A 302 (-3.2A)
ZN  A 302 ( 4.7A)
ZN  A 302 (-3.1A)
ZN  A 302 (-3.1A)
None
 0.76A 3hy7A-4q1lA:
26.4		 3hy7A-4q1lA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 302 (-3.2A)
ZN  A 302 ( 4.7A)
ZN  A 302 (-3.1A)
ZN  A 302 (-3.1A)
 0.21A 3hy7A-4q1lA:
26.4		 3hy7A-4q1lA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhi UNCHARACTERIZED
PROTEIN MJ1213

(Methanocaldococcus
jannaschii) 		PF01435
(Peptidase_M48) 		5 HIS A  69
GLU A  70
HIS A  73
HIS A  80
LEU A  99
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
None
 1.00A 3hy7A-4qhiA:
2.5		 3hy7A-4qhiA:
18.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		7 ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.30A 3hy7A-4wk7A:
34.8		 3hy7A-4wk7A:
47.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 N73  A 301 (-4.4A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.47A 3hy7A-4xctA:
11.4		 3hy7A-4xctA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 LEU A 356
HIS A 360
HIS A  43
ILE A  47
LEU A  48
 None
 1.35A 3hy7A-4yu9A:
undetectable		 3hy7A-4yu9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 LEU A 247
HIS A 268
HIS A 272
HIS A 348
LEU A 243
 None
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
None
 1.02A 3hy7A-4zr1A:
undetectable		 3hy7A-4zr1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		5 LEU A 277
THR A 281
GLU A 283
ILE A 365
LEU A 225
 None
 1.33A 3hy7A-4zxwA:
undetectable		 3hy7A-4zxwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvi SLOR

(Streptococcus
mutans) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		5 LEU A 101
HIS A  76
GLU A 102
HIS A  95
ILE A  94
 None
ZN  A 303 (-3.2A)
ZN  A 301 (-3.0A)
ZN  A 303 (-3.1A)
None
 1.30A 3hy7A-5cviA:
undetectable		 3hy7A-5cviA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvi SLOR

(Streptococcus
mutans) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		5 LEU A 101
HIS A  76
GLU A 102
HIS A  95
LEU A  83
 None
ZN  A 303 (-3.2A)
ZN  A 301 (-3.0A)
ZN  A 303 (-3.1A)
None
 1.29A 3hy7A-5cviA:
undetectable		 3hy7A-5cviA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 301 ( 3.4A)
ZN  A 301 ( 4.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.1A)
 0.32A 3hy7A-5czwA:
7.8		 3hy7A-5czwA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 THR A 173
HIS A 176
GLU A 177
HIS A 180
HIS A 186
 THR  A 173 ( 0.8A)
HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.32A 3hy7A-5d7wA:
7.7		 3hy7A-5d7wA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		5 HIS A 570
HIS A 359
HIS A 364
ILE A 394
LEU A 665
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
None
None
 1.30A 3hy7A-5ek8A:
undetectable		 3hy7A-5ek8A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 ASP b 205
LEU b 203
THR b 376
ILE b 198
LEU b 369
 None
 1.33A 3hy7A-5gw5b:
undetectable		 3hy7A-5gw5b:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0u MATRIX
METALLOPROTEINASE-14

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 199
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 GOL  A 312 (-4.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.43A 3hy7A-5h0uA:
10.5		 3hy7A-5h0uA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C

(Schizosaccharomyces
pombe) 		PF08325
(WLM) 		6 LEU A  63
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.34A 3hy7A-5jigA:
3.8		 3hy7A-5jigA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 None
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.36A 3hy7A-5th6A:
9.4		 3hy7A-5th6A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbn WSS1P

(Saccharomyces
cerevisiae) 		no annotation 6 LEU A  80
THR A 112
HIS A 115
GLU A 116
HIS A 119
HIS A 125
 None
None
ZN  A 201 (-3.2A)
ZN  A 201 ( 4.7A)
ZN  A 201 (-3.3A)
ZN  A 201 (-3.2A)
 0.30A 3hy7A-5xbnA:
3.9		 3hy7A-5xbnA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1i CYTOCHROME P450

(Streptomyces
graminofaciens) 		PF00067
(p450) 		5 LEU A 290
HIS A 353
GLU A 288
ILE A 296
LEU A 294
 None
 1.21A 3hy7A-5y1iA:
undetectable		 3hy7A-5y1iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 569
THR A 537
HIS A 540
GLU A 541
HIS A 544
 None
None
ZN  A 802 (-3.4A)
None
ZN  A 802 (-3.3A)
 0.46A 3hy7A-6az0A:
undetectable		 3hy7A-6az0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 5 ASP A 325
HIS A 383
GLU A 384
HIS A 387
HIS A 393
 None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
 0.73A 3hy7A-6bdzA:
20.1		 3hy7A-6bdzA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 6 LEU A 328
THR A 380
HIS A 383
GLU A 384
HIS A 387
HIS A 393
 None
None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
 0.65A 3hy7A-6bdzA:
20.1		 3hy7A-6bdzA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 5 ASP D 132
HIS D 140
HIS D  94
ILE D 185
LEU D 184
 None
 1.28A 3hy7A-6cg0D:
undetectable		 3hy7A-6cg0D:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cim V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 5 ASP B 132
HIS B 140
HIS B  94
ILE B 185
LEU B 184
 None
 1.30A 3hy7A-6cimB:
undetectable		 3hy7A-6cimB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN

(Caldithrix
abyssi) 		no annotation 5 LEU A 318
THR A 376
HIS A 379
GLU A 380
HIS A 383
 LYS  A 606 ( 4.1A)
None
ZN  A 601 (-3.2A)
None
ZN  A 601 (-3.2A)
 0.52A 3hy7A-6eomA:
undetectable		 3hy7A-6eomA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g6s APOPTOTIC CHROMATIN
CONDENSATION INDUCER
IN THE NUCLEUS

(Homo sapiens) 		no annotation 5 LEU A1092
HIS A1015
GLU A1091
HIS A1051
ILE A1045
 None
 1.23A 3hy7A-6g6sA:
undetectable		 3hy7A-6g6sA:
18.62