SIMILAR PATTERNS OF AMINO ACIDS FOR 3HUO_A_PNNA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		5 THR A  51
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.29A 3huoA-1bsgA:
43.1		 3huoA-1bsgA:
46.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bue PROTEIN
(IMIPENEM-HYDROLYSIN
G BETA-LACTAMASE)

(Enterobacter
cloacae) 		PF13354
(Beta-lactamase2) 		5 THR A  51
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.25A 3huoA-1bueA:
41.0		 3huoA-1bueA:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		5 THR A  51
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.26A 3huoA-1dy6A:
41.2		 3huoA-1dy6A:
47.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 THR A  51
GLY A 196
ALA A 257
PRO A 258
 None
 0.45A 3huoA-1g68A:
39.7		 3huoA-1g68A:
39.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		5 THR A  51
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.32A 3huoA-1hzoA:
46.4		 3huoA-1hzoA:
65.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1g TRANSCRIPTIONAL
REGULATOR LRPA

(Pyrococcus
furiosus) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		5 THR A  66
LEU A 114
GLY A 111
ALA A 134
PRO A 133
 None
 1.14A 3huoA-1i1gA:
undetectable		 3huoA-1i1gA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9r IMMUNOGLOBULIN H

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 194
GLY H 195
ALA H 130
PRO H 131
 None
 0.31A 3huoA-1i9rH:
undetectable		 3huoA-1i9rH:
23.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		5 THR A  51
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.51A 3huoA-1n4oA:
40.5		 3huoA-1n4oA:
46.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pkq (8-18C5) CHIMERIC
FAB, HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 189
GLY B 190
ALA B 125
PRO B 126
 None
 0.50A 3huoA-1pkqB:
undetectable		 3huoA-1pkqB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzf FAB E51 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.37A 3huoA-1rzfH:
undetectable		 3huoA-1rzfH:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzg FAB 412D LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 189
GLY A 190
ALA A 125
PRO A 126
 None
 0.43A 3huoA-1rzgA:
undetectable		 3huoA-1rzgA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t04 HUZAF ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 193
GLY B 194
ALA B 129
PRO B 130
 None
 0.51A 3huoA-1t04B:
undetectable		 3huoA-1t04B:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um4 ANTIBODY 21H3 H
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 195
GLY H 196
ALA H 131
PRO H 132
 None
 0.51A 3huoA-1um4H:
undetectable		 3huoA-1um4H:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwe ANTIBODY 14D9

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.51A 3huoA-1uweH:
undetectable		 3huoA-1uweH:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1h FAB 2219, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 198
GLY H 199
ALA H 125
PRO H 126
 None
 0.35A 3huoA-2b1hH:
undetectable		 3huoA-2b1hH:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4c ANTI-HIV-1 GP120
IMMUNOGLOBULIN X5
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.45A 3huoA-2b4cH:
undetectable		 3huoA-2b4cH:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 THR A 238
LEU A 235
GLY A 231
ALA A 299
PRO A 298
 None
 1.20A 3huoA-2cdqA:
undetectable		 3huoA-2cdqA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 THR A 238
LEU A 235
GLY A 232
ALA A 299
PRO A 298
 None
None
LYS  A 601 (-3.6A)
None
None
 1.05A 3huoA-2cdqA:
undetectable		 3huoA-2cdqA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh7 HUMANIZED KR127 FAB,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.46A 3huoA-2eh7H:
undetectable		 3huoA-2eh7H:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 208
GLY H 209
ALA H 144
PRO H 145
 None
 0.47A 3huoA-2f5aH:
undetectable		 3huoA-2f5aH:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gry KINESIN-LIKE PROTEIN
KIF2

(Homo sapiens) 		PF00225
(Kinesin) 		5 THR A 220
ARG A 178
LEU A 181
GLY A 179
PRO A 222
 None
 1.49A 3huoA-2gryA:
undetectable		 3huoA-2gryA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlj HYPOTHETICAL PROTEIN

(Pseudomonas
putida) 		PF13279
(4HBT_2) 		4 LEU A  82
GLY A  83
ALA A 144
PRO A 145
 None
 0.47A 3huoA-2hljA:
undetectable		 3huoA-2hljA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r56 IGE FAB FRAGMENT,
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 197
GLY H 198
ALA H 133
PRO H 134
 None
 0.45A 3huoA-2r56H:
undetectable		 3huoA-2r56H:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 THR A  51
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.34A 3huoA-2wyxA:
46.1		 3huoA-2wyxA:
83.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bfg CLASS A
BETA-LACTAMASE SED1

(Citrobacter
sedlakii) 		PF13354
(Beta-lactamase2) 		6 THR A  51
ARG A 191
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.28A 3huoA-3bfgA:
46.7		 3huoA-3bfgA:
74.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3byd BETA-LACTAMASE OXY-1

(Klebsiella
oxytoca) 		PF13354
(Beta-lactamase2) 		6 THR A  55
ARG A 194
LEU A 198
GLY A 199
ALA A 258
PRO A 259
 None
 0.29A 3huoA-3bydA:
47.1		 3huoA-3bydA:
74.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d85 FAB OF ANTIBODY
7G10, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 191
GLY B 192
ALA B 127
PRO B 128
 None
 0.51A 3huoA-3d85B:
undetectable		 3huoA-3d85B:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 189
GLY B 190
ALA B 125
PRO B 126
 None
 0.41A 3huoA-3g04B:
undetectable		 3huoA-3g04B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc4 IMMUNOGLOBULIN IGG1
FAB, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 192
GLY H 193
ALA H 128
PRO H 129
 None
 0.46A 3huoA-3hc4H:
undetectable		 3huoA-3hc4H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		5 THR A 110
LEU A 393
GLY A 394
ALA A 112
PRO A  51
 None
 1.41A 3huoA-3ihgA:
undetectable		 3huoA-3ihgA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7f H2L6 HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU H 197
GLY H 198
ALA H 133
PRO H 134
 None
 0.50A 3huoA-3l7fH:
undetectable		 3huoA-3l7fH:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnz ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 198
GLY B 199
ALA B 125
PRO B 126
 None
 0.44A 3huoA-3mnzB:
undetectable		 3huoA-3mnzB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxw 5E1 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.49A 3huoA-3mxwH:
undetectable		 3huoA-3mxwH:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntc FAB HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.53A 3huoA-3ntcH:
undetectable		 3huoA-3ntcH:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzh 5F6 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 193
GLY H 194
ALA H 129
PRO H 130
 None
 0.41A 3huoA-3nzhH:
undetectable		 3huoA-3nzhH:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcv LT3015 ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.52A 3huoA-3qcvH:
undetectable		 3huoA-3qcvH:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qeh FAB FRAGMENT OF
HUMAN ANTI-HIV-1 ENV
ANTIBODY N12-I15,
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 189
GLY A 190
ALA A 125
PRO A 126
 None
 0.46A 3huoA-3qehA:
undetectable		 3huoA-3qehA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qhy BETA-LACTAMASE

(Bacillus
anthracis) 		PF13354
(Beta-lactamase2) 		4 THR A  51
GLY A 196
ALA A 257
PRO A 258
 None
 0.52A 3huoA-3qhyA:
41.9		 3huoA-3qhyA:
43.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpx FAB C2507 HEAVY
CHAIN

(Homo sapiens;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 195
GLY H 196
ALA H 131
PRO H 132
 None
 0.53A 3huoA-3qpxH:
undetectable		 3huoA-3qpxH:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		4 LEU A 140
GLY A 139
ALA A 152
PRO A 153
 None
 0.47A 3huoA-3rpwA:
undetectable		 3huoA-3rpwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcl CH04 HEAVY CHAIN FAB

(Homo sapiens) 		no annotation 4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.49A 3huoA-3tclH:
undetectable		 3huoA-3tclH:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tje FAB E09, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 208
GLY H 209
ALA H 144
PRO H 145
 None
 0.51A 3huoA-3tjeH:
undetectable		 3huoA-3tjeH:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1s FAB PGT145 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 194
GLY H 195
ALA H 130
PRO H 131
 None
 0.49A 3huoA-3u1sH:
undetectable		 3huoA-3u1sH:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w4q BETA-LACTAMASE

(Burkholderia
multivorans) 		PF13354
(Beta-lactamase2) 		5 THR A  52
ARG A 191
LEU A 195
GLY A 196
ALA A  53
 None
 1.27A 3huoA-3w4qA:
44.1		 3huoA-3w4qA:
57.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w4q BETA-LACTAMASE

(Burkholderia
multivorans) 		PF13354
(Beta-lactamase2) 		6 THR A  52
ARG A 191
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.50A 3huoA-3w4qA:
44.1		 3huoA-3w4qA:
57.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		6 THR A  51
ARG A 191
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.62A 3huoA-3znyA:
47.7		 3huoA-3znyA:
81.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		5 THR A  51
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.24A 3huoA-4c6yA:
43.5		 3huoA-4c6yA:
58.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		6 THR A  51
ARG A 191
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.42A 3huoA-4c75A:
42.6		 3huoA-4c75A:
56.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmh HEAVY CHAIN OF
SAR650984-FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 196
GLY B 197
ALA B 132
PRO B 133
 None
 0.52A 3huoA-4cmhB:
undetectable		 3huoA-4cmhB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3c SFN68 FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 192
GLY H 193
ALA H 128
PRO H 129
 None
 0.49A 3huoA-4d3cH:
undetectable		 3huoA-4d3cH:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fql MONOCLONAL ANTIBODY
CR8033 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.47A 3huoA-4fqlH:
undetectable		 3huoA-4fqlH:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpv PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
eggerthii) 		PF06321
(P_gingi_FimA) 		5 THR A 359
LEU A 172
GLY A 154
ALA A  64
PRO A 361
 None
 1.23A 3huoA-4gpvA:
undetectable		 3huoA-4gpvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfw 6-26 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU H 196
GLY H 197
ALA H 132
PRO H 133
 None
 0.34A 3huoA-4hfwH:
undetectable		 3huoA-4hfwH:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwe FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 195
GLY H 196
ALA H 131
PRO H 132
 None
 0.48A 3huoA-4hweH:
undetectable		 3huoA-4hweH:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3r HEAVY CHAIN OF
VRC-PG04 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.51A 3huoA-4i3rH:
undetectable		 3huoA-4i3rH:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn2 ANTI DABIGATRAN FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 199
GLY B 200
ALA B 135
PRO B 136
 None
 0.52A 3huoA-4jn2B:
undetectable		 3huoA-4jn2B:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jy4 PGT121 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 187
GLY B 188
ALA B 123
PRO B 124
 None
 0.50A 3huoA-4jy4B:
undetectable		 3huoA-4jy4B:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktd GE136 HEAVY CHAIN
FAB

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.49A 3huoA-4ktdH:
undetectable		 3huoA-4ktdH:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 THR A 347
ARG A 218
LEU A 215
GLY A 216
ALA A 348
 None
 1.37A 3huoA-4l87A:
undetectable		 3huoA-4l87A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01041
(DegT_DnrJ_EryC1) 		5 THR A  97
ARG A  70
LEU A  69
GLY A  68
ALA A  99
 None
 1.39A 3huoA-4lc3A:
undetectable		 3huoA-4lc3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lly MUTATED PERTUZUMAB
FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 195
GLY A 196
ALA A 131
PRO A 132
 None
 0.39A 3huoA-4llyA:
undetectable		 3huoA-4llyA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lri MSL-109 HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU P 206
GLY P 207
ALA P 142
PRO P 143
 None
 0.46A 3huoA-4lriP:
undetectable		 3huoA-4lriP:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5y FAB 5J8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.44A 3huoA-4m5yH:
undetectable		 3huoA-4m5yH:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxv ANTI-LYMPHOTOXIN
ALPHA ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU F 189
GLY F 190
ALA F 125
PRO F 126
 None
 0.41A 3huoA-4mxvF:
undetectable		 3huoA-4mxvF:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9g ANTIBODY 17HD9,
HEAVY CHAIN

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 189
GLY A 190
ALA A 125
PRO A 126
 None
 0.43A 3huoA-4n9gA:
undetectable		 3huoA-4n9gA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oaw HEAVY CHAIN OF FAB
FRAGMENT OF
ANTI-HIV1 GP120 V2
MAB 2158

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 206
GLY B 207
ALA B 142
PRO B 143
 None
 0.47A 3huoA-4oawB:
undetectable		 3huoA-4oawB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ocw CAP256-VRC26.06
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.48A 3huoA-4ocwH:
undetectable		 3huoA-4ocwH:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4f ANTIBODY 2.2C HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.43A 3huoA-4r4fH:
undetectable		 3huoA-4r4fH:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 198
GLY H 199
ALA H 134
PRO H 135
 None
 0.53A 3huoA-4r90H:
undetectable		 3huoA-4r90H:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET H
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 195
GLY B 196
ALA B 131
PRO B 132
 None
 0.43A 3huoA-4r96B:
undetectable		 3huoA-4r96B:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnr PGT130 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 189
GLY A 190
ALA A 125
PRO A 126
 None
 0.50A 3huoA-4rnrA:
undetectable		 3huoA-4rnrA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU H 194
GLY H 195
ALA H 130
PRO H 131
 None
 0.48A 3huoA-4rqqH:
undetectable		 3huoA-4rqqH:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uta BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 198
GLY H 199
ALA H 134
PRO H 135
 None
 0.48A 3huoA-4utaH:
undetectable		 3huoA-4utaH:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuu IMMUNOGLOBULIN HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU E 197
GLY E 198
ALA E 133
PRO E 134
 None
 0.43A 3huoA-4wuuE:
undetectable		 3huoA-4wuuE:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvs VRC07_1995
45-VRC01.H01+07.O-86
3513/45-VRC01.L01+07
.O-110653 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 201
GLY H 202
ALA H 137
PRO H 138
 None
 0.45A 3huoA-4xvsH:
undetectable		 3huoA-4xvsH:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydv HIV ANTIBODY 7B2
HEAVY CHAIN,IGG H
CHAIN

(Homo sapiens) 		no annotation 4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.53A 3huoA-4ydvH:
undetectable		 3huoA-4ydvH:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		5 THR A  53
ARG A 190
LEU A 194
ALA A 254
PRO A 255
 None
 0.43A 3huoA-4yfmA:
42.0		 3huoA-4yfmA:
43.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs7 LLAMA FAB FRAGMENT
68F2 HEAVY CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 198
GLY H 199
ALA H 134
PRO H 135
 None
 0.53A 3huoA-4zs7H:
undetectable		 3huoA-4zs7H:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.39A 3huoA-5alcH:
undetectable		 3huoA-5alcH:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd3 DRVIA7 HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU G 188
GLY G 189
ALA G 124
PRO G 125
 None
 0.52A 3huoA-5cd3G:
undetectable		 3huoA-5cd3G:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chn ANTIBODY 5M16 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU H 198
GLY H 199
ALA H 134
PRO H 135
 None
 0.44A 3huoA-5chnH:
undetectable		 3huoA-5chnH:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		4 LEU A 172
GLY A 173
ALA A 232
PRO A 233
 None
 0.42A 3huoA-5e2eA:
44.3		 3huoA-5e2eA:
58.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2w AT8 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.38A 3huoA-5e2wH:
undetectable		 3huoA-5e2wH:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum) 		PF13354
(Beta-lactamase2) 		5 THR A  52
ARG A 192
GLY A 197
ALA A 258
PRO A 259
 None
 0.72A 3huoA-5e43A:
42.7		 3huoA-5e43A:
41.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv CH03 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 189
GLY A 190
ALA A 125
PRO A 126
 None
 0.52A 3huoA-5esvA:
undetectable		 3huoA-5esvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f96 HEAVY CHAIN OF
ANTIBODY CH235.12

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.52A 3huoA-5f96H:
undetectable		 3huoA-5f96H:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9o CH235.9 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 198
GLY H 199
ALA H 134
PRO H 135
 None
 0.53A 3huoA-5f9oH:
undetectable		 3huoA-5f9oH:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis) 		PF13354
(Beta-lactamase2) 		5 THR A  52
ARG A 191
GLY A 196
ALA A 257
PRO A 258
 None
 0.65A 3huoA-5gl9A:
45.1		 3huoA-5gl9A:
57.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		5 THR A  52
LEU A 194
GLY A 195
ALA A 254
PRO A 255
 None
 0.31A 3huoA-5hw3A:
39.9		 3huoA-5hw3A:
37.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		5 THR A  52
LEU A 195
GLY A 196
ALA A 255
PRO A 256
 None
 0.39A 3huoA-5hx9A:
41.9		 3huoA-5hx9A:
46.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ies VRC01CHUGL2 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.52A 3huoA-5iesH:
undetectable		 3huoA-5iesH:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		5 THR A  29
LEU A 172
GLY A 173
ALA A 232
PRO A 233
 None
 0.47A 3huoA-5ihvA:
42.1		 3huoA-5ihvA:
49.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxa VRC03 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.53A 3huoA-5jxaH:
undetectable		 3huoA-5jxaH:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kw9 IGA(VH)-IGG(CH)
HEAVY CHAIN FAB
FRAGMENT

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 200
GLY H 201
ALA H 136
PRO H 137
 None
 0.50A 3huoA-5kw9H:
undetectable		 3huoA-5kw9H:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 THR A  51
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.24A 3huoA-5ll7A:
42.8		 3huoA-5ll7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbi DESIGN OF ANTIBODIES

(Escherichia
coli) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 197
GLY H 198
ALA H 133
PRO H 134
 None
 0.52A 3huoA-5nbiH:
undetectable		 3huoA-5nbiH:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ob5 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU H 195
GLY H 196
ALA H 131
PRO H 132
 None
 0.53A 3huoA-5ob5H:
undetectable		 3huoA-5ob5H:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trp DH272 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 198
GLY H 199
ALA H 134
PRO H 135
 None
 0.48A 3huoA-5trpH:
undetectable		 3huoA-5trpH:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3n DH511.12P FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.44A 3huoA-5u3nH:
undetectable		 3huoA-5u3nH:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uem 354NC37 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.45A 3huoA-5uemH:
undetectable		 3huoA-5uemH:
undetectable