SIMILAR PATTERNS OF AMINO ACIDS FOR 3HS6_B_EPAB1_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 PHE A 112
VAL A 117
VAL A 119
VAL A  91
 None
 0.92A 3hs6B-1a6aA:
0.0		 3hs6B-1a6aA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus) 		PF00079
(Serpin) 		4 PHE A 122
VAL A  49
LEU A  52
SER A  53
 None
 0.88A 3hs6B-1attA:
0.0		 3hs6B-1attA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awj ITK

(Mus musculus) 		PF00018
(SH3_1) 		4 PHE A  17
VAL A  76
LEU A  75
SER A  72
 None
 0.86A 3hs6B-1awjA:
undetectable		 3hs6B-1awjA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 VAL A 118
VAL A 120
LEU A 121
SER A 122
 None
 0.89A 3hs6B-1bjwA:
0.0		 3hs6B-1bjwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H

(Streptomyces
plicatus) 		PF00704
(Glyco_hydro_18) 		4 PHE A 149
VAL A 153
LEU A 115
SER A 116
 PHE  A 149 ( 1.3A)
VAL  A 153 ( 0.6A)
LEU  A 115 ( 0.6A)
SER  A 116 ( 0.0A)
 0.92A 3hs6B-1c8xA:
0.0		 3hs6B-1c8xA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci0 PROTEIN (PNP
OXIDASE)

(Saccharomyces
cerevisiae) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		5 PHE A 198
VAL A 119
VAL A 121
TRP A 221
VAL A 192
 None
 1.41A 3hs6B-1ci0A:
0.0		 3hs6B-1ci0A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de4 HEMOCHROMATOSIS
PROTEIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 PHE A  76
VAL A  98
LEU A 124
TRP A 147
 None
 0.91A 3hs6B-1de4A:
0.0		 3hs6B-1de4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 VAL A 140
VAL A 144
LEU A 147
SER A 148
 None
 0.90A 3hs6B-1dlcA:
0.0		 3hs6B-1dlcA:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 PHE A 205
VAL A 344
VAL A 349
LEU A 352
SER A 353
TRP A 387
 OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
 0.31A 3hs6B-1ebvA:
30.3		 3hs6B-1ebvA:
63.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elk TARGET OF MYB1

(Homo sapiens) 		PF00790
(VHS) 		4 VAL A 113
VAL A 117
LEU A 120
VAL A  95
 None
 0.68A 3hs6B-1elkA:
undetectable		 3hs6B-1elkA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL B 242
VAL B 246
LEU B 249
SER B 250
 None
 0.68A 3hs6B-1ffvB:
0.0		 3hs6B-1ffvB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		4 VAL A 249
VAL A 245
LEU A 242
SER A 241
 None
 0.85A 3hs6B-1fhuA:
undetectable		 3hs6B-1fhuA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B 109
VAL B 111
SER B 113
VAL B 199
 None
 0.92A 3hs6B-1fn4B:
undetectable		 3hs6B-1fn4B:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 PHE A 491
VAL A 474
VAL A 478
LEU A 483
 None
 0.88A 3hs6B-1gq2A:
undetectable		 3hs6B-1gq2A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		4 PHE A 320
VAL A 281
LEU A 305
VAL A 316
 None
 0.86A 3hs6B-1h6uA:
undetectable		 3hs6B-1h6uA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		4 VAL A  41
LEU A  42
SER A  39
VAL A 362
 None
 0.92A 3hs6B-1hqsA:
0.0		 3hs6B-1hqsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j7j HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF00156
(Pribosyltran) 		4 VAL A  39
VAL A  95
LEU A 123
SER A 122
 None
 0.77A 3hs6B-1j7jA:
undetectable		 3hs6B-1j7jA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 VAL A 561
VAL A 543
LEU A 544
SER A 541
TRP A 586
 None
 1.44A 3hs6B-1jqoA:
0.3		 3hs6B-1jqoA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Thermotoga
maritima) 		PF01259
(SAICAR_synt) 		5 PHE A 113
VAL A  84
VAL A  86
LEU A 110
VAL A 108
 None
 1.40A 3hs6B-1kutA:
undetectable		 3hs6B-1kutA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lki LEUKEMIA INHIBITORY
FACTOR

(Mus musculus) 		PF01291
(LIF_OSM) 		4 PHE A  70
VAL A  87
LEU A  90
SER A  91
 None
 0.61A 3hs6B-1lkiA:
undetectable		 3hs6B-1lkiA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 VAL A 547
VAL A 558
LEU A 565
SER A 568
 None
 0.87A 3hs6B-1ms8A:
undetectable		 3hs6B-1ms8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 VAL B 379
VAL B 383
LEU B 386
SER B 387
 None
 0.90A 3hs6B-1pjmB:
undetectable		 3hs6B-1pjmB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0f SUPEROXIDE DISMUTASE
[NI]

(Streptomyces
seoulensis) 		PF09055
(Sod_Ni) 		4 VAL A  78
VAL A  82
LEU A  85
SER A  86
 None
 0.79A 3hs6B-1q0fA:
undetectable		 3hs6B-1q0fA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		4 VAL A  29
VAL A  98
LEU A 122
SER A 121
 None
 0.78A 3hs6B-1q0zA:
undetectable		 3hs6B-1q0zA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		4 PHE A 253
VAL A 200
LEU A 338
SER A 339
 None
 0.91A 3hs6B-1q50A:
undetectable		 3hs6B-1q50A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME
ALPHA-TYPE SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		4 VAL A 181
VAL A 185
LEU A 188
VAL A 201
 None
 0.83A 3hs6B-1q5qA:
0.0		 3hs6B-1q5qA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		5 VAL A 501
VAL A 483
LEU A 484
SER A 481
TRP A 526
 None
 1.42A 3hs6B-1qb4A:
undetectable		 3hs6B-1qb4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		4 VAL A 431
VAL A 435
LEU A 438
SER A 439
 None
 0.88A 3hs6B-1qhbA:
undetectable		 3hs6B-1qhbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu9 YJGF PROTEIN

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		5 VAL A  61
VAL A  57
LEU A  54
SER A  53
VAL A  76
 None
 1.44A 3hs6B-1qu9A:
undetectable		 3hs6B-1qu9A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE

(Escherichia
coli) 		PF02567
(PhzC-PhzF) 		4 VAL A 105
LEU A 118
SER A 117
VAL A  77
 None
 0.89A 3hs6B-1qy9A:
undetectable		 3hs6B-1qy9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj7 TALIN 1

(Mus musculus) 		PF09141
(Talin_middle) 		4 VAL A 573
VAL A 577
SER A 581
VAL A 619
 None
 0.74A 3hs6B-1sj7A:
undetectable		 3hs6B-1sj7A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj8 TALIN 1

(Mus musculus) 		PF09141
(Talin_middle) 		4 VAL A 573
VAL A 577
SER A 581
VAL A 619
 None
 0.90A 3hs6B-1sj8A:
undetectable		 3hs6B-1sj8A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 VAL A  56
VAL A  60
LEU A  63
SER A  64
 None
 0.59A 3hs6B-1t6xA:
undetectable		 3hs6B-1t6xA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmx HYDROXYQUINOL
1,2-DIOXYGENASE

(Pimelobacter
simplex) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 189
VAL A 136
VAL A 284
SER A 261
VAL A 259
 None
 1.48A 3hs6B-1tmxA:
undetectable		 3hs6B-1tmxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr7 FIMH PROTEIN

(Escherichia
coli) 		no annotation 4 VAL B  75
VAL B 105
LEU B  38
SER B  39
 None
 0.90A 3hs6B-1tr7B:
undetectable		 3hs6B-1tr7B:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		4 VAL A 126
VAL A 130
LEU A 133
SER A 134
 None
 0.86A 3hs6B-1uazA:
undetectable		 3hs6B-1uazA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 VAL A 282
VAL A 286
LEU A 289
SER A 290
 None
 0.89A 3hs6B-1uedA:
undetectable		 3hs6B-1uedA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 VAL A 425
VAL A 429
LEU A 432
VAL A  24
 None
 0.82A 3hs6B-1vrdA:
undetectable		 3hs6B-1vrdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		4 VAL A  96
VAL A 100
LEU A 103
VAL A 112
 None
 0.82A 3hs6B-1wleA:
undetectable		 3hs6B-1wleA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		4 PHE A 107
VAL A  91
VAL A  95
LEU A  98
 None
 0.69A 3hs6B-1xe4A:
undetectable		 3hs6B-1xe4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi6 EXTRAGENIC
SUPPRESSOR

(Pyrococcus
furiosus) 		PF00459
(Inositol_P) 		4 VAL A  65
VAL A  83
LEU A 103
SER A 102
 None
 0.87A 3hs6B-1xi6A:
undetectable		 3hs6B-1xi6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yby TRANSLATION
ELONGATION FACTOR P

(Ruminiclostridium
thermocellum) 		PF01132
(EFP)
PF08207
(EFP_N)
PF09285
(Elong-fact-P_C) 		4 VAL A 111
VAL A 113
LEU A 114
SER A 115
 None
 0.81A 3hs6B-1ybyA:
undetectable		 3hs6B-1ybyA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625

(Archaeoglobus
fulgidus) 		PF04414
(tRNA_deacylase) 		4 PHE A 219
VAL A 250
VAL A 254
VAL A 231
 None
 0.90A 3hs6B-1yqeA:
undetectable		 3hs6B-1yqeA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z63 HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 PHE A 871
LEU A 890
SER A 891
TRP A 886
 None
 0.91A 3hs6B-1z63A:
undetectable		 3hs6B-1z63A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		4 VAL A 167
VAL A 165
LEU A 164
SER A 163
 None
 0.64A 3hs6B-1ztvA:
undetectable		 3hs6B-1ztvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 VAL A  93
LEU A  96
SER A  97
VAL A  84
 None
 0.72A 3hs6B-2ag8A:
0.6		 3hs6B-2ag8A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 PHE A 478
VAL A 461
VAL A 465
LEU A 470
 None
 0.86A 3hs6B-2aw5A:
undetectable		 3hs6B-2aw5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0k HEMOGLOBIN

(Gasterophilus
intestinalis) 		PF00042
(Globin) 		4 PHE A 136
VAL A  70
VAL A  74
LEU A  77
 None
 0.91A 3hs6B-2c0kA:
undetectable		 3hs6B-2c0kA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		4 PHE A 120
VAL A  31
VAL A  29
LEU A  28
 None
 0.83A 3hs6B-2c2qA:
undetectable		 3hs6B-2c2qA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A1267
VAL A1271
LEU A1274
VAL A1243
 None
 0.80A 3hs6B-2cfvA:
undetectable		 3hs6B-2cfvA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 VAL A 281
LEU A 288
SER A 289
VAL A 239
 None
 0.87A 3hs6B-2cvoA:
undetectable		 3hs6B-2cvoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 VAL A  89
VAL A  93
LEU A  96
SER A  97
 None
 0.53A 3hs6B-2dg8A:
undetectable		 3hs6B-2dg8A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		4 VAL A 118
VAL A 215
LEU A 259
SER A 258
 None
 0.75A 3hs6B-2ef4A:
undetectable		 3hs6B-2ef4A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Rattus
norvegicus) 		PF12796
(Ank_2) 		4 VAL A 184
VAL A 180
LEU A 177
SER A 176
 None
 0.71A 3hs6B-2etaA:
undetectable		 3hs6B-2etaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Homo sapiens) 		PF12796
(Ank_2) 		4 VAL A 183
VAL A 179
LEU A 176
SER A 175
 None
 0.74A 3hs6B-2f37A:
undetectable		 3hs6B-2f37A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		4 VAL A 150
VAL A 154
LEU A 157
SER A 158
 None
 0.80A 3hs6B-2f7nA:
undetectable		 3hs6B-2f7nA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
GAMMA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF04268
(SoxG) 		4 VAL C 186
VAL C 190
SER C 194
VAL C  28
 None
 0.92A 3hs6B-2gahC:
undetectable		 3hs6B-2gahC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		5 PHE A 187
VAL A 192
VAL A 163
LEU A 331
SER A 332
 None
 1.38A 3hs6B-2gfiA:
undetectable		 3hs6B-2gfiA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		5 PHE A 187
VAL A 192
VAL A 163
SER A 332
VAL A 171
 None
 1.24A 3hs6B-2gfiA:
undetectable		 3hs6B-2gfiA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		5 PHE A 275
VAL A 479
VAL A 483
LEU A 441
VAL A 453
 None
 1.40A 3hs6B-2gwcA:
undetectable		 3hs6B-2gwcA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		4 PHE A 533
VAL A 563
LEU A 566
SER A 567
 None
 0.88A 3hs6B-2hwkA:
undetectable		 3hs6B-2hwkA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i10 PUTATIVE TETR
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 VAL A 162
VAL A 166
LEU A 169
SER A 170
 None
 0.79A 3hs6B-2i10A:
undetectable		 3hs6B-2i10A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ill TITIN

(Homo sapiens) 		PF07679
(I-set) 		4 VAL A 151
LEU A 160
SER A 159
VAL A 176
 None
 0.84A 3hs6B-2illA:
undetectable		 3hs6B-2illA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 PHE A 934
VAL A 789
LEU A 796
SER A 795
 None
 0.82A 3hs6B-2ipcA:
1.4		 3hs6B-2ipcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 VAL A  68
VAL A 294
LEU A 260
SER A 261
TRP A 124
 None
MHO  A 292 ( 4.5A)
None
MHO  A 292 ( 3.9A)
None
 1.18A 3hs6B-2iqfA:
undetectable		 3hs6B-2iqfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		4 PHE A 193
VAL A 148
VAL A 152
LEU A 155
 None
 0.81A 3hs6B-2irwA:
undetectable		 3hs6B-2irwA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 VAL A 705
VAL A 701
SER A 697
VAL A 474
 None
None
None
ADP  A1723 (-3.7A)
 0.92A 3hs6B-2iuuA:
undetectable		 3hs6B-2iuuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 VAL A1222
VAL A1226
LEU A1229
VAL A1267
 None
 0.45A 3hs6B-2ix8A:
undetectable		 3hs6B-2ix8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh2 O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00963
(Cohesin) 		4 VAL A  98
VAL A  30
LEU A  14
SER A  13
 None
 0.80A 3hs6B-2jh2A:
undetectable		 3hs6B-2jh2A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lmr ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 1A

(Homo sapiens) 		PF07647
(SAM_2) 		4 PHE A  53
LEU A  90
SER A  89
VAL A  93
 None
 0.90A 3hs6B-2lmrA:
undetectable		 3hs6B-2lmrA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsm DNA-PACKAGING
PROTEIN FI

(Escherichia
virus Lambda) 		PF14000
(Packaging_FI) 		4 PHE A 113
VAL A  85
VAL A  83
LEU A  82
 None
 0.84A 3hs6B-2lsmA:
undetectable		 3hs6B-2lsmA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4n PROTEIN AFD-1,
ISOFORM A

(Caenorhabditis
elegans) 		PF00788
(RA) 		4 PHE A 100
VAL A  56
VAL A  54
LEU A  53
 None
 0.89A 3hs6B-2m4nA:
undetectable		 3hs6B-2m4nA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzi TITIN

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		4 VAL A 150
LEU A 159
SER A 158
VAL A 175
 None
 0.87A 3hs6B-2nziA:
undetectable		 3hs6B-2nziA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of3 ZYG-9

(Caenorhabditis
elegans) 		no annotation 4 VAL A 753
VAL A 757
LEU A 760
SER A 761
 None
 0.70A 3hs6B-2of3A:
undetectable		 3hs6B-2of3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5t PEZT

(Streptococcus
pneumoniae) 		PF06414
(Zeta_toxin) 		4 VAL B  98
VAL B 102
LEU B 105
SER B 106
 None
 0.73A 3hs6B-2p5tB:
undetectable		 3hs6B-2p5tB:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 VAL A 166
VAL A 170
LEU A 173
SER A 174
 None
 0.48A 3hs6B-2rgwA:
undetectable		 3hs6B-2rgwA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 VAL A1160
LEU A1152
TRP A1112
VAL A1028
 None
 0.91A 3hs6B-2rhpA:
0.7		 3hs6B-2rhpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1n O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00041
(fn3)
PF00963
(Cohesin) 		4 VAL A 865
VAL A 797
LEU A 781
SER A 780
 None
 0.79A 3hs6B-2w1nA:
undetectable		 3hs6B-2w1nA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 VAL A 155
VAL A 159
LEU A 162
VAL A 189
 None
 0.64A 3hs6B-2wnrA:
undetectable		 3hs6B-2wnrA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 VAL A 908
VAL A 970
LEU A1023
VAL A 983
 None
 0.83A 3hs6B-2x2iA:
undetectable		 3hs6B-2x2iA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		4 VAL A 277
VAL A 281
LEU A 284
SER A 285
 None
 0.92A 3hs6B-2x98A:
undetectable		 3hs6B-2x98A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 AP-2 COMPLEX SUBUNIT
BETA

(Homo sapiens) 		PF01602
(Adaptin_N) 		4 VAL B 177
VAL B 181
LEU B 184
SER B 185
 None
 0.86A 3hs6B-2xa7B:
undetectable		 3hs6B-2xa7B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xri ERI1 EXORIBONUCLEASE
3

(Homo sapiens) 		PF00929
(RNase_T) 		4 VAL A 224
VAL A 220
LEU A 217
SER A 216
 None
 0.86A 3hs6B-2xriA:
undetectable		 3hs6B-2xriA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 VAL A 565
VAL A 479
LEU A 587
SER A 586
 None
 0.86A 3hs6B-2xtlA:
undetectable		 3hs6B-2xtlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5j DIHYDROPTEROATE
SYNTHASE

(Burkholderia
cenocepacia) 		PF00809
(Pterin_bind) 		4 VAL A 272
VAL A 276
LEU A 279
SER A 280
 None
EDO  A1295 (-3.3A)
EDO  A1295 (-3.5A)
None
 0.80A 3hs6B-2y5jA:
undetectable		 3hs6B-2y5jA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 VAL A 212
VAL A 216
LEU A 219
VAL A 228
 None
 0.79A 3hs6B-2yijA:
undetectable		 3hs6B-2yijA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yiu CYTOCHROME B

(Paracoccus
denitrificans) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 VAL A 314
VAL A 318
LEU A 321
SER A 322
 None
 0.69A 3hs6B-2yiuA:
undetectable		 3hs6B-2yiuA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2b DIHYDROOROTASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 PHE A 146
VAL A 128
VAL A 163
LEU A 184
 None
 0.84A 3hs6B-2z2bA:
undetectable		 3hs6B-2z2bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		4 VAL A 314
VAL A 318
LEU A 321
SER A 322
 None
 0.89A 3hs6B-2z67A:
0.3		 3hs6B-2z67A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a64 CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 VAL A 126
VAL A 130
LEU A 133
SER A 134
 None
 0.90A 3hs6B-3a64A:
undetectable		 3hs6B-3a64A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bba INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10) 		4 VAL A 320
VAL A 318
LEU A 317
VAL A 112
 None
 0.87A 3hs6B-3bbaA:
undetectable		 3hs6B-3bbaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ble CITRAMALATE SYNTHASE
FROM LEPTOSPIRA
INTERROGANS

(Leptospira
interrogans) 		PF00682
(HMGL-like) 		4 VAL A 159
VAL A 163
LEU A 166
SER A 167
 None
 0.38A 3hs6B-3bleA:
undetectable		 3hs6B-3bleA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 PHE A 199
VAL A 228
VAL A 230
SER A 247
 None
 0.91A 3hs6B-3brqA:
undetectable		 3hs6B-3brqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		4 VAL A   4
VAL A   9
LEU A  12
VAL A 156
 None
 0.91A 3hs6B-3bxoA:
undetectable		 3hs6B-3bxoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		4 PHE B  91
LEU B  82
SER B  84
TRP B 125
 None
 0.86A 3hs6B-3cfiB:
undetectable		 3hs6B-3cfiB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		4 PHE B  91
LEU B  82
TRP B 125
VAL B 138
 None
 0.78A 3hs6B-3cfiB:
undetectable		 3hs6B-3cfiB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36

(Homo sapiens) 		PF04157
(EAP30) 		4 VAL B 273
VAL B 269
LEU B 266
SER B 265
 None
 0.83A 3hs6B-3cuqB:
undetectable		 3hs6B-3cuqB:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfu UNCHARACTERIZED
PROTEIN FROM
6-PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
FAMILY

(Corynebacterium
glutamicum) 		PF10727
(Rossmann-like) 		4 VAL A  53
VAL A  57
LEU A  60
SER A  61
 None
 0.71A 3hs6B-3dfuA:
undetectable		 3hs6B-3dfuA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3erw SPORULATION
THIOL-DISULFIDE
OXIDOREDUCTASE A

(Bacillus
subtilis) 		PF00578
(AhpC-TSA) 		5 PHE A  60
VAL A  92
VAL A  90
LEU A  89
VAL A  87
 None
 1.34A 3hs6B-3erwA:
undetectable		 3hs6B-3erwA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		4 VAL A 355
VAL A 359
LEU A 362
VAL A 406
 None
 0.83A 3hs6B-3ez1A:
undetectable		 3hs6B-3ez1A:
21.50