SIMILAR PATTERNS OF AMINO ACIDS FOR 3HS6_B_EPAB1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b88 T CELL RECEPTOR
V-ALPHA DOMAIN

(Mus musculus) 		PF07686
(V-set) 		5 PHE A  66
ILE A  50
PHE A  33
TYR A  25
ALA A  94
 None
 1.00A 3hs6B-1b88A:
undetectable		 3hs6B-1b88A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)
PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN)

(Cupriavidus
necator) 		PF00016
(RuBisCO_large)
PF00101
(RuBisCO_small)
PF02788
(RuBisCO_large_N) 		5 TYR I 123
ILE A 409
GLY A 189
GLY A 195
LEU A 196
 None
 0.96A 3hs6B-1bxnI:
undetectable		 3hs6B-1bxnI:
12.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 PHE A 209
GLY A 227
TYR A 355
ASN A 375
ILE A 377
PHE A 381
TYR A 385
GLY A 526
ALA A 527
GLY A 533
LEU A 534
 None
None
SCL  A 700 (-4.3A)
None
None
OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 4.0A)
OAS  A 530 ( 3.3A)
 0.38A 3hs6B-1ebvA:
30.3		 3hs6B-1ebvA:
63.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 PHE A 210
TYR A 355
ILE A 377
PHE A 381
GLY A 526
ALA A 527
 HEM  A 601 (-4.7A)
SCL  A 700 (-4.3A)
None
OAS  A 530 ( 4.7A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 1.34A 3hs6B-1ebvA:
30.3		 3hs6B-1ebvA:
63.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gae D-GLYCERALDEHYDE-3-P
HOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 TYR O 311
ASN O 222
GLY O 209
ALA O 210
GLY O 215
 None
 0.95A 3hs6B-1gaeO:
0.0		 3hs6B-1gaeO:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		5 ASN A 409
ILE A 446
PHE A 103
GLY A 307
LEU A 366
 None
 1.02A 3hs6B-1h3gA:
0.0		 3hs6B-1h3gA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd3 CHORISMATE LYASE

(Escherichia
coli) 		PF04345
(Chor_lyase) 		5 TYR A 164
GLY A 136
ALA A 135
GLY A 132
LEU A  11
 None
 0.92A 3hs6B-1jd3A:
0.0		 3hs6B-1jd3A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE A 946
GLY A 945
ASN A 567
GLY A 597
SER A 599
 None
 1.02A 3hs6B-1kqfA:
0.0		 3hs6B-1kqfA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE

(Thermotoga
maritima) 		PF04961
(FTCD_C) 		5 GLY A  25
ALA A  26
SER A  29
GLY A  32
LEU A  73
 None
 0.79A 3hs6B-1o5hA:
undetectable		 3hs6B-1o5hA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME
ALPHA-TYPE SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		5 GLY A  66
ILE A  24
GLY A 145
ALA A 104
LEU A  74
 None
 1.02A 3hs6B-1q5qA:
0.0		 3hs6B-1q5qA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 GLY A  23
ILE A 132
TYR A  54
ALA A  82
SER A  96
 None
 1.02A 3hs6B-1qgzA:
undetectable		 3hs6B-1qgzA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcw CT610

(Chlamydia
trachomatis) 		PF03070
(TENA_THI-4) 		5 GLY A  33
TYR A  27
ALA A 149
GLY A 155
LEU A 156
 None
 0.98A 3hs6B-1rcwA:
undetectable		 3hs6B-1rcwA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3h T-CELL RECEPTOR
ALPHA-CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 PHE A  66
ILE A  49
PHE A  32
TYR A  24
ALA A  98
 None
 0.94A 3hs6B-1u3hA:
undetectable		 3hs6B-1u3hA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		5 ILE A 492
GLY A 193
ALA A 159
SER A 190
LEU A 186
 None
 0.92A 3hs6B-1uc4A:
undetectable		 3hs6B-1uc4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		6 TYR A 326
ASN A  44
GLY A  13
ALA A 347
SER A  11
GLY A  34
 None
 1.48A 3hs6B-1vkzA:
undetectable		 3hs6B-1vkzA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		5 TYR A 402
ASN A 306
GLY A  10
GLY A 362
LEU A 353
 None
SUG  A1001 ( 4.1A)
None
None
None
 1.02A 3hs6B-1yniA:
undetectable		 3hs6B-1yniA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5o FERREDOXIN--NADP
REDUCTASE

(Synechococcus
sp. PCC 7002) 		PF00175
(NAD_binding_1) 		5 GLY A 125
ILE A 235
TYR A 156
ALA A 184
SER A 198
 None
 0.99A 3hs6B-2b5oA:
undetectable		 3hs6B-2b5oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 5 GLY A 280
GLY A  76
ALA A  77
GLY A  83
LEU A  84
 None
 0.82A 3hs6B-2d4yA:
0.2		 3hs6B-2d4yA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 5 GLY A 281
GLY A  76
ALA A  77
GLY A  83
LEU A  84
 None
 0.69A 3hs6B-2d4yA:
0.2		 3hs6B-2d4yA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgj HYPOTHETICAL PROTEIN
EBHA

(Staphylococcus
aureus) 		PF01468
(GA) 		5 ASN A 137
GLY A 127
ALA A 128
SER A 131
GLY A 134
 None
 0.89A 3hs6B-2dgjA:
undetectable		 3hs6B-2dgjA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		5 PHE A 378
GLY A 377
PHE A  75
GLY A 131
ALA A 130
 None
 0.89A 3hs6B-2oodA:
undetectable		 3hs6B-2oodA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p10 MLL9387 PROTEIN

(Mesorhizobium
japonicum) 		PF09370
(PEP_hydrolase) 		5 GLY A  35
GLY A  46
ALA A  45
SER A  42
LEU A  38
 None
 0.99A 3hs6B-2p10A:
undetectable		 3hs6B-2p10A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  56
ASN A  55
ILE A  59
GLY A 459
ALA A 460
 None
None
None
PG4  A1596 ( 4.6A)
None
 0.90A 3hs6B-2v6oA:
undetectable		 3hs6B-2v6oA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		5 PHE A 306
GLY A 307
ASN A 312
ILE A 313
ALA A  61
 None
 1.03A 3hs6B-2vsgA:
undetectable		 3hs6B-2vsgA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		5 GLY A 251
ILE A 243
ALA A 297
SER A 270
GLY A 245
 None
 1.02A 3hs6B-2z5lA:
undetectable		 3hs6B-2z5lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 ILE A 388
TYR A  24
GLY A 255
ALA A 256
LEU A 379
 None
 1.03A 3hs6B-3abbA:
0.0		 3hs6B-3abbA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 PHE A 173
GLY A 174
TYR A 350
GLY A 358
LEU A 147
 None
 0.82A 3hs6B-3c8tA:
undetectable		 3hs6B-3c8tA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 181
PHE A 205
GLY A 204
ALA A 203
LEU A 282
 None
 1.00A 3hs6B-3dh9A:
undetectable		 3hs6B-3dh9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmc NTF2-LIKE PROTEIN

(Trichormus
variabilis) 		PF12680
(SnoaL_2) 		5 PHE A  63
PHE A  32
GLY A  16
GLY A  23
LEU A  24
 None
 1.01A 3hs6B-3dmcA:
undetectable		 3hs6B-3dmcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00199
(Catalase) 		5 GLY A  79
ASN A  66
GLY A  19
ALA A  26
GLY A  67
 None
None
None
HEM  A 501 (-3.4A)
HEZ  A1100 ( 3.7A)
 1.02A 3hs6B-3e4wA:
undetectable		 3hs6B-3e4wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A  66
ILE A  24
GLY A 145
ALA A 104
LEU A  74
 None
 0.95A 3hs6B-3hf9A:
undetectable		 3hs6B-3hf9A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 GLY A 498
ASN A 508
ILE A 506
GLY A 240
GLY A 361
 None
 1.00A 3hs6B-3higA:
undetectable		 3hs6B-3higA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu CHLOROPHYLL A-B
BINDING PROTEIN 29
KD (CP29)

(Spinacia
oleracea) 		PF00504
(Chloroa_b-bind) 		5 PHE R 211
GLY R 207
ALA R 204
GLY R 109
LEU R 108
 LUT  R 620 (-3.8A)
LUT  R 620 (-3.9A)
LUT  R 620 (-3.5A)
CLA  R 604 (-3.2A)
CLA  R 604 (-4.4A)
 1.01A 3hs6B-3jcuR:
undetectable		 3hs6B-3jcuR:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC

(Pisum sativum) 		PF00175
(NAD_binding_1) 		5 GLY A  34
ILE A 141
TYR A  64
ALA A  92
SER A 106
 None
 1.00A 3hs6B-3mhpA:
undetectable		 3hs6B-3mhpA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP

(Vibrio cholerae) 		PF01554
(MatE) 		5 GLY A 295
GLY A 313
ALA A 315
GLY A 321
LEU A 322
 None
 0.90A 3hs6B-3mktA:
undetectable		 3hs6B-3mktA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntn USPA1

(Moraxella
catarrhalis) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 224
ASN A 227
ILE A 237
GLY A 270
SER A 255
 None
 0.99A 3hs6B-3ntnA:
undetectable		 3hs6B-3ntnA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozz CYTOCHROME B5

(Bos taurus) 		PF00173
(Cyt-b5) 		5 GLY B  77
ILE B  76
GLY B  51
ALA B  52
LEU B  79
 None
 0.98A 3hs6B-3ozzB:
undetectable		 3hs6B-3ozzB:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe8 ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 ASN A  96
ILE A  95
GLY A  65
ALA A  28
GLY A  57
 None
 0.82A 3hs6B-3pe8A:
undetectable		 3hs6B-3pe8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 TYR A 196
ILE A  53
GLY A 127
ALA A 128
LEU A 189
 GOL  A 522 ( 4.8A)
None
None
None
None
 0.96A 3hs6B-3pfeA:
undetectable		 3hs6B-3pfeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr7 USPA1

(Moraxella
catarrhalis) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 224
ASN A 227
ILE A 237
GLY A 270
SER A 255
 None
 1.02A 3hs6B-3pr7A:
undetectable		 3hs6B-3pr7A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyr ECHA16_2

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 ASN A  95
ILE A  94
GLY A  64
ALA A  27
GLY A  56
 None
 0.81A 3hs6B-3qyrA:
undetectable		 3hs6B-3qyrA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ILE A  22
GLY A 286
ALA A 285
SER A  34
GLY A 395
 None
 0.90A 3hs6B-3vabA:
undetectable		 3hs6B-3vabA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		5 GLY A  40
ILE A 147
TYR A  70
ALA A  98
SER A 112
 None
 1.00A 3hs6B-3vo2A:
undetectable		 3hs6B-3vo2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 PHE A  99
GLY A 100
ILE A 126
ALA A  39
LEU A 106
 None
 1.03A 3hs6B-3vpxA:
undetectable		 3hs6B-3vpxA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		5 GLY A 100
GLY A 143
ALA A 144
GLY A 149
LEU A 151
 None
 0.92A 3hs6B-3wo8A:
0.0		 3hs6B-3wo8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus) 		PF01464
(SLT) 		6 GLY A 105
TYR A 180
GLY A  77
ALA A  76
GLY A 109
LEU A 113
 None
 1.21A 3hs6B-3wyhA:
undetectable		 3hs6B-3wyhA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		5 GLY A 255
GLY A 496
ALA A 498
GLY A 503
LEU A 504
 None
 0.98A 3hs6B-4ainA:
undetectable		 3hs6B-4ainA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		5 GLY A 454
GLY A 257
ALA A 258
GLY A 264
LEU A 265
 None
 0.86A 3hs6B-4ainA:
undetectable		 3hs6B-4ainA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 GLY A 551
GLY A 630
ALA A 631
GLY A 636
LEU A 638
 None
 1.01A 3hs6B-4av6A:
undetectable		 3hs6B-4av6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		5 PHE A 182
GLY A 137
GLY A 329
ALA A 327
GLY A 145
 None
 1.01A 3hs6B-4bgbA:
undetectable		 3hs6B-4bgbA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 GLY A 138
ILE A 142
GLY A  47
ALA A  45
LEU A  39
 None
 0.93A 3hs6B-4bjuA:
0.6		 3hs6B-4bjuA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Corynebacterium
glutamicum) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		5 ASN A 146
ILE A 251
GLY A 241
ALA A 240
GLY A 117
 None
 0.87A 3hs6B-4dbhA:
undetectable		 3hs6B-4dbhA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dna PROBABLE GLUTATHIONE
REDUCTASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 GLY A  21
ILE A  33
TYR A  99
GLY A  41
SER A  15
GLY A  17
 None
None
None
FAD  A 500 (-3.4A)
FAD  A 500 (-3.9A)
None
 1.36A 3hs6B-4dnaA:
undetectable		 3hs6B-4dnaA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezd UREA TRANSPORTER 1

(Bos taurus) 		PF03253
(UT) 		5 GLY A 266
ILE A 276
ALA A 256
GLY A 262
LEU A 261
 None
 1.00A 3hs6B-4ezdA:
undetectable		 3hs6B-4ezdA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe1 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI

(Thermosynechococcus
elongatus) 		PF02605
(PsaL) 		5 PHE L 124
GLY L  51
ALA L  84
GLY L  55
LEU L  58
 BCR  L1005 (-4.3A)
None
None
None
None
 0.99A 3hs6B-4fe1L:
0.7		 3hs6B-4fe1L:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 309
ASN A 317
GLY A 342
SER A 134
GLY A 319
 None
 0.91A 3hs6B-4izgA:
undetectable		 3hs6B-4izgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF16417
(CNOT1_TTP_bind) 		5 GLY A 944
ILE A 945
PHE A 974
ALA A 966
LEU A 929
 None
 0.97A 3hs6B-4j8sA:
undetectable		 3hs6B-4j8sA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 GLY A 168
ASN A 171
GLY A 191
ALA A 192
LEU A 173
 None
 0.96A 3hs6B-4jgiA:
undetectable		 3hs6B-4jgiA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjt ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 ASN A  95
ILE A  94
GLY A  64
ALA A  27
GLY A  56
 None
 0.81A 3hs6B-4jjtA:
undetectable		 3hs6B-4jjtA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0d PERIPLASMIC SENSOR
HYBRID HISTIDINE
KINASE

(Anaeromyxobacter
dehalogenans) 		no annotation 5 PHE A 162
GLY A 107
ALA A 108
SER A 111
LEU A 115
 None
 0.99A 3hs6B-4k0dA:
undetectable		 3hs6B-4k0dA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Brugia malayi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 TYR A 319
ASN A 230
GLY A 217
ALA A 218
GLY A 223
 None
 0.92A 3hs6B-4k9dA:
undetectable		 3hs6B-4k9dA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5f PUTATIVE ACYL-COA
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 241
ASN A 238
ILE A  54
GLY A 121
ALA A 122
 None
 1.02A 3hs6B-4n5fA:
undetectable		 3hs6B-4n5fA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bos taurus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 TYR O 311
ASN O 222
GLY O 209
ALA O 210
GLY O 215
 None
 0.97A 3hs6B-4o59O:
undetectable		 3hs6B-4o59O:
18.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 PHE A 210
GLY A 228
TYR A 356
ASN A 376
ILE A 378
PHE A 382
ALA A 528
SER A 531
GLY A 534
 EDO  A 616 (-3.5A)
EDO  A 616 ( 4.5A)
IBP  A 601 (-4.5A)
EDO  A 616 (-4.4A)
None
None
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
EDO  A 616 (-3.0A)
 0.72A 3hs6B-4ph9A:
63.6		 3hs6B-4ph9A:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 PHE A 210
GLY A 228
TYR A 356
ASN A 376
ILE A 378
PHE A 382
TYR A 386
GLY A 527
ALA A 528
GLY A 534
LEU A 535
 EDO  A 616 (-3.5A)
EDO  A 616 ( 4.5A)
IBP  A 601 (-4.5A)
EDO  A 616 (-4.4A)
None
None
IBP  A 601 (-4.8A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
EDO  A 616 (-3.0A)
EDO  A 616 ( 4.4A)
 0.38A 3hs6B-4ph9A:
63.6		 3hs6B-4ph9A:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 PHE A 211
TYR A 356
ILE A 378
PHE A 382
ALA A 528
SER A 531
 HEM  A 602 (-4.6A)
IBP  A 601 (-4.5A)
None
None
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
 1.29A 3hs6B-4ph9A:
63.6		 3hs6B-4ph9A:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 PHE A 211
TYR A 356
ILE A 378
PHE A 382
GLY A 527
ALA A 528
 HEM  A 602 (-4.6A)
IBP  A 601 (-4.5A)
None
None
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
 1.37A 3hs6B-4ph9A:
63.6		 3hs6B-4ph9A:
99.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		5 TYR A 190
ASN A   5
ILE A  87
GLY A 177
LEU A 152
 None
 0.98A 3hs6B-4rcdA:
undetectable		 3hs6B-4rcdA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		6 GLY A 103
ASN A 242
GLY A  70
ALA A  69
GLY A 257
LEU A 258
 PMP  A 409 (-3.4A)
None
None
None
None
None
 1.43A 3hs6B-4rkcA:
undetectable		 3hs6B-4rkcA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		5 ILE A  83
ALA A  57
SER A  60
GLY A  64
LEU A 340
 None
 0.88A 3hs6B-4ug4A:
undetectable		 3hs6B-4ug4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		5 GLY A 109
TYR A 152
ILE A 116
GLY A 120
GLY A 107
 None
None
None
P6G  A1649 ( 3.3A)
None
 1.02A 3hs6B-4uirA:
undetectable		 3hs6B-4uirA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 TYR O 311
ASN O 222
GLY O 209
ALA O 210
GLY O 215
 None
None
SO4  O 403 (-3.9A)
SO4  O 403 ( 3.8A)
None
 0.93A 3hs6B-4z0hO:
undetectable		 3hs6B-4z0hO:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 153
ILE A 283
ALA A 143
SER A 147
GLY A 149
 None
 0.91A 3hs6B-5b37A:
undetectable		 3hs6B-5b37A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		6 ASN A  94
ILE A  93
GLY A  59
ALA A  23
GLY A  51
LEU A  15
 None
 1.12A 3hs6B-5dtpA:
undetectable		 3hs6B-5dtpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 GLY A 298
PHE A 324
GLY A  75
ALA A  77
GLY A  82
 None
 0.98A 3hs6B-5gmxA:
undetectable		 3hs6B-5gmxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
T-COMPLEX PROTEIN 1
SUBUNIT ETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 GLY e 118
ILE e 115
GLY h 381
ALA h 382
LEU e 107
 None
 1.02A 3hs6B-5gw5e:
undetectable		 3hs6B-5gw5e:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 GLY A 899
TYR A 123
ASN A 164
SER A 161
GLY A 147
 None
 0.97A 3hs6B-5h42A:
undetectable		 3hs6B-5h42A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i45 GLYCOSYL
TRANSFERASES GROUP 1
FAMILY PROTEIN

(Francisella
tularensis) 		PF00534
(Glycos_transf_1) 		5 ILE A 170
GLY A 280
ALA A 279
SER A 255
GLY A 179
 None
 0.96A 3hs6B-5i45A:
undetectable		 3hs6B-5i45A:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 PHE A 209
GLY A 227
TYR A 355
ASN A 375
ILE A 377
PHE A 381
TYR A 385
GLY A 526
ALA A 527
SER A 530
GLY A 533
LEU A 534
 None
None
ID8  A 601 (-3.8A)
None
None
None
ID8  A 601 ( 3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
None
 0.28A 3hs6B-5ikrA:
61.8		 3hs6B-5ikrA:
87.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 PHE A 210
TYR A 355
ILE A 377
PHE A 381
GLY A 526
ALA A 527
SER A 530
 COH  A 602 (-4.0A)
ID8  A 601 (-3.8A)
None
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 1.30A 3hs6B-5ikrA:
61.8		 3hs6B-5ikrA:
87.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw1 T-CELL RECEPTOR
ALPHA CHAIN

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		5 PHE A  67
ILE A  51
PHE A  34
TYR A  26
ALA A  95
 None
 0.99A 3hs6B-5iw1A:
undetectable		 3hs6B-5iw1A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 TYR A 318
ASN A 230
GLY A 217
ALA A 218
GLY A 223
 None
 0.87A 3hs6B-5j9gA:
undetectable		 3hs6B-5j9gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Atopobium
vaginae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 TYR A 334
ASN A 242
GLY A 229
ALA A 230
GLY A 235
 None
None
GOL  A 404 (-2.8A)
GOL  A 404 (-3.3A)
None
 0.92A 3hs6B-5ld5A:
undetectable		 3hs6B-5ld5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A 485
ASN A 417
GLY A 348
ALA A 411
GLY A 418
 None
 1.02A 3hs6B-5neuA:
undetectable		 3hs6B-5neuA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI

(Synechocystis
sp. PCC 6803) 		no annotation 5 PHE 0 127
GLY 0  54
ALA 0  87
GLY 0  58
LEU 0  61
 BCR  0 204 (-4.0A)
None
None
None
None
 0.97A 3hs6B-5oy00:
1.2		 3hs6B-5oy00:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		6 GLY A  63
ASN A  64
GLY A 146
ALA A 147
GLY A 140
LEU A 139
 None
 1.09A 3hs6B-5tp4A:
undetectable		 3hs6B-5tp4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Naegleria
gruberi) 		no annotation 5 TYR A 312
ASN A 222
GLY A 209
ALA A 210
GLY A 215
 OCS  A 149 ( 4.1A)
None
None
None
None
 0.90A 3hs6B-5ur0A:
undetectable		 3hs6B-5ur0A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 5 PHE A 162
ILE A 169
PHE A 173
TYR A 150
GLY A 142
 None
 1.02A 3hs6B-5vf5A:
undetectable		 3hs6B-5vf5A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vft PROTEASOME SUBUNIT
BETA TYPE-4

(Homo sapiens) 		no annotation 5 GLY T  28
ILE T  39
GLY T  52
SER T  54
GLY T   8
 None
 1.01A 3hs6B-5vftT:
undetectable		 3hs6B-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 TYR A 313
ASN A 225
GLY A 212
ALA A 213
GLY A 218
 None
 0.91A 3hs6B-5vmtA:
undetectable		 3hs6B-5vmtA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 PHE A 163
GLY A 164
GLY A 357
ALA A 356
LEU A 137
 None
 0.73A 3hs6B-5xnzA:
undetectable		 3hs6B-5xnzA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
agalactiae) 		no annotation 5 TYR A 318
ASN A 230
GLY A 217
ALA A 218
GLY A 223
 None
 0.86A 3hs6B-5y37A:
undetectable		 3hs6B-5y37A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR

(Galdieria
sulphuraria) 		PF03151
(TPT) 		5 PHE A 272
GLY A 211
ALA A 212
SER A 215
LEU A 219
 OLC  A 507 (-4.8A)
None
None
None
None
 0.98A 3hs6B-5y79A:
undetectable		 3hs6B-5y79A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 5 GLY A  51
ILE A  61
GLY A 265
ALA A 261
LEU A  48
 None
None
NA  A 401 (-3.5A)
None
None
 0.84A 3hs6B-5yu1A:
undetectable		 3hs6B-5yu1A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 5 GLY B 197
PHE B  41
TYR B  34
GLY B 140
LEU B 155
 None
SO4  B 305 (-4.0A)
NAG  B 309 ( 3.6A)
None
None
 1.01A 3hs6B-6b74B:
undetectable		 3hs6B-6b74B:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 6 GLY A 494
ILE A 491
PHE A 451
ALA A 465
SER A 449
GLY A 447
 None
 1.40A 3hs6B-6byxA:
undetectable		 3hs6B-6byxA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 5 PHE A 414
PHE A 399
GLY A 324
GLY A 360
LEU A 364
 None
 1.00A 3hs6B-6c0eA:
undetectable		 3hs6B-6c0eA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehc OUTER MEMBRANE
PROTEIN U

(Vibrio cholerae) 		no annotation 5 GLY A 143
GLY A 203
ALA A 202
GLY A 149
LEU A 148
 None
 0.79A 3hs6B-6ehcA:
undetectable		 3hs6B-6ehcA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 5 TYR A 599
ASN A 414
ILE A 496
GLY A 586
LEU A 561
 None
 0.99A 3hs6B-6ej2A:
undetectable		 3hs6B-6ej2A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 5 PHE A 470
GLY A 498
ILE A 494
GLY A 362
ALA A 363
 None
 0.98A 3hs6B-6gngA:
undetectable		 3hs6B-6gngA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 PHE A 112
VAL A 117
VAL A 119
VAL A  91
 None
 0.92A 3hs6B-1a6aA:
0.0		 3hs6B-1a6aA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus) 		PF00079
(Serpin) 		4 PHE A 122
VAL A  49
LEU A  52
SER A  53
 None
 0.88A 3hs6B-1attA:
0.0		 3hs6B-1attA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awj ITK

(Mus musculus) 		PF00018
(SH3_1) 		4 PHE A  17
VAL A  76
LEU A  75
SER A  72
 None
 0.86A 3hs6B-1awjA:
undetectable		 3hs6B-1awjA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 VAL A 118
VAL A 120
LEU A 121
SER A 122
 None
 0.89A 3hs6B-1bjwA:
0.0		 3hs6B-1bjwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H

(Streptomyces
plicatus) 		PF00704
(Glyco_hydro_18) 		4 PHE A 149
VAL A 153
LEU A 115
SER A 116
 PHE  A 149 ( 1.3A)
VAL  A 153 ( 0.6A)
LEU  A 115 ( 0.6A)
SER  A 116 ( 0.0A)
 0.92A 3hs6B-1c8xA:
0.0		 3hs6B-1c8xA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci0 PROTEIN (PNP
OXIDASE)

(Saccharomyces
cerevisiae) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		5 PHE A 198
VAL A 119
VAL A 121
TRP A 221
VAL A 192
 None
 1.41A 3hs6B-1ci0A:
0.0		 3hs6B-1ci0A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de4 HEMOCHROMATOSIS
PROTEIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 PHE A  76
VAL A  98
LEU A 124
TRP A 147
 None
 0.91A 3hs6B-1de4A:
0.0		 3hs6B-1de4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 VAL A 140
VAL A 144
LEU A 147
SER A 148
 None
 0.90A 3hs6B-1dlcA:
0.0		 3hs6B-1dlcA:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 PHE A 205
VAL A 344
VAL A 349
LEU A 352
SER A 353
TRP A 387
 OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
 0.31A 3hs6B-1ebvA:
30.3		 3hs6B-1ebvA:
63.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elk TARGET OF MYB1

(Homo sapiens) 		PF00790
(VHS) 		4 VAL A 113
VAL A 117
LEU A 120
VAL A  95
 None
 0.68A 3hs6B-1elkA:
undetectable		 3hs6B-1elkA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL B 242
VAL B 246
LEU B 249
SER B 250
 None
 0.68A 3hs6B-1ffvB:
0.0		 3hs6B-1ffvB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		4 VAL A 249
VAL A 245
LEU A 242
SER A 241
 None
 0.85A 3hs6B-1fhuA:
undetectable		 3hs6B-1fhuA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B 109
VAL B 111
SER B 113
VAL B 199
 None
 0.92A 3hs6B-1fn4B:
undetectable		 3hs6B-1fn4B:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 PHE A 491
VAL A 474
VAL A 478
LEU A 483
 None
 0.88A 3hs6B-1gq2A:
undetectable		 3hs6B-1gq2A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		4 PHE A 320
VAL A 281
LEU A 305
VAL A 316
 None
 0.86A 3hs6B-1h6uA:
undetectable		 3hs6B-1h6uA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		4 VAL A  41
LEU A  42
SER A  39
VAL A 362
 None
 0.92A 3hs6B-1hqsA:
0.0		 3hs6B-1hqsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j7j HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF00156
(Pribosyltran) 		4 VAL A  39
VAL A  95
LEU A 123
SER A 122
 None
 0.77A 3hs6B-1j7jA:
undetectable		 3hs6B-1j7jA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 VAL A 561
VAL A 543
LEU A 544
SER A 541
TRP A 586
 None
 1.44A 3hs6B-1jqoA:
0.3		 3hs6B-1jqoA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Thermotoga
maritima) 		PF01259
(SAICAR_synt) 		5 PHE A 113
VAL A  84
VAL A  86
LEU A 110
VAL A 108
 None
 1.40A 3hs6B-1kutA:
undetectable		 3hs6B-1kutA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lki LEUKEMIA INHIBITORY
FACTOR

(Mus musculus) 		PF01291
(LIF_OSM) 		4 PHE A  70
VAL A  87
LEU A  90
SER A  91
 None
 0.61A 3hs6B-1lkiA:
undetectable		 3hs6B-1lkiA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 VAL A 547
VAL A 558
LEU A 565
SER A 568
 None
 0.87A 3hs6B-1ms8A:
undetectable		 3hs6B-1ms8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 VAL B 379
VAL B 383
LEU B 386
SER B 387
 None
 0.90A 3hs6B-1pjmB:
undetectable		 3hs6B-1pjmB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0f SUPEROXIDE DISMUTASE
[NI]

(Streptomyces
seoulensis) 		PF09055
(Sod_Ni) 		4 VAL A  78
VAL A  82
LEU A  85
SER A  86
 None
 0.79A 3hs6B-1q0fA:
undetectable		 3hs6B-1q0fA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		4 VAL A  29
VAL A  98
LEU A 122
SER A 121
 None
 0.78A 3hs6B-1q0zA:
undetectable		 3hs6B-1q0zA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		4 PHE A 253
VAL A 200
LEU A 338
SER A 339
 None
 0.91A 3hs6B-1q50A:
undetectable		 3hs6B-1q50A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME
ALPHA-TYPE SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		4 VAL A 181
VAL A 185
LEU A 188
VAL A 201
 None
 0.83A 3hs6B-1q5qA:
0.0		 3hs6B-1q5qA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		5 VAL A 501
VAL A 483
LEU A 484
SER A 481
TRP A 526
 None
 1.42A 3hs6B-1qb4A:
undetectable		 3hs6B-1qb4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		4 VAL A 431
VAL A 435
LEU A 438
SER A 439
 None
 0.88A 3hs6B-1qhbA:
undetectable		 3hs6B-1qhbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu9 YJGF PROTEIN

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		5 VAL A  61
VAL A  57
LEU A  54
SER A  53
VAL A  76
 None
 1.44A 3hs6B-1qu9A:
undetectable		 3hs6B-1qu9A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE

(Escherichia
coli) 		PF02567
(PhzC-PhzF) 		4 VAL A 105
LEU A 118
SER A 117
VAL A  77
 None
 0.89A 3hs6B-1qy9A:
undetectable		 3hs6B-1qy9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj7 TALIN 1

(Mus musculus) 		PF09141
(Talin_middle) 		4 VAL A 573
VAL A 577
SER A 581
VAL A 619
 None
 0.74A 3hs6B-1sj7A:
undetectable		 3hs6B-1sj7A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj8 TALIN 1

(Mus musculus) 		PF09141
(Talin_middle) 		4 VAL A 573
VAL A 577
SER A 581
VAL A 619
 None
 0.90A 3hs6B-1sj8A:
undetectable		 3hs6B-1sj8A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 VAL A  56
VAL A  60
LEU A  63
SER A  64
 None
 0.59A 3hs6B-1t6xA:
undetectable		 3hs6B-1t6xA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmx HYDROXYQUINOL
1,2-DIOXYGENASE

(Pimelobacter
simplex) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 189
VAL A 136
VAL A 284
SER A 261
VAL A 259
 None
 1.48A 3hs6B-1tmxA:
undetectable		 3hs6B-1tmxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr7 FIMH PROTEIN

(Escherichia
coli) 		no annotation 4 VAL B  75
VAL B 105
LEU B  38
SER B  39
 None
 0.90A 3hs6B-1tr7B:
undetectable		 3hs6B-1tr7B:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		4 VAL A 126
VAL A 130
LEU A 133
SER A 134
 None
 0.86A 3hs6B-1uazA:
undetectable		 3hs6B-1uazA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 VAL A 282
VAL A 286
LEU A 289
SER A 290
 None
 0.89A 3hs6B-1uedA:
undetectable		 3hs6B-1uedA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 VAL A 425
VAL A 429
LEU A 432
VAL A  24
 None
 0.82A 3hs6B-1vrdA:
undetectable		 3hs6B-1vrdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		4 VAL A  96
VAL A 100
LEU A 103
VAL A 112
 None
 0.82A 3hs6B-1wleA:
undetectable		 3hs6B-1wleA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		4 PHE A 107
VAL A  91
VAL A  95
LEU A  98
 None
 0.69A 3hs6B-1xe4A:
undetectable		 3hs6B-1xe4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi6 EXTRAGENIC
SUPPRESSOR

(Pyrococcus
furiosus) 		PF00459
(Inositol_P) 		4 VAL A  65
VAL A  83
LEU A 103
SER A 102
 None
 0.87A 3hs6B-1xi6A:
undetectable		 3hs6B-1xi6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yby TRANSLATION
ELONGATION FACTOR P

(Ruminiclostridium
thermocellum) 		PF01132
(EFP)
PF08207
(EFP_N)
PF09285
(Elong-fact-P_C) 		4 VAL A 111
VAL A 113
LEU A 114
SER A 115
 None
 0.81A 3hs6B-1ybyA:
undetectable		 3hs6B-1ybyA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625

(Archaeoglobus
fulgidus) 		PF04414
(tRNA_deacylase) 		4 PHE A 219
VAL A 250
VAL A 254
VAL A 231
 None
 0.90A 3hs6B-1yqeA:
undetectable		 3hs6B-1yqeA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z63 HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 PHE A 871
LEU A 890
SER A 891
TRP A 886
 None
 0.91A 3hs6B-1z63A:
undetectable		 3hs6B-1z63A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		4 VAL A 167
VAL A 165
LEU A 164
SER A 163
 None
 0.64A 3hs6B-1ztvA:
undetectable		 3hs6B-1ztvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 VAL A  93
LEU A  96
SER A  97
VAL A  84
 None
 0.72A 3hs6B-2ag8A:
0.6		 3hs6B-2ag8A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 PHE A 478
VAL A 461
VAL A 465
LEU A 470
 None
 0.86A 3hs6B-2aw5A:
undetectable		 3hs6B-2aw5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0k HEMOGLOBIN

(Gasterophilus
intestinalis) 		PF00042
(Globin) 		4 PHE A 136
VAL A  70
VAL A  74
LEU A  77
 None
 0.91A 3hs6B-2c0kA:
undetectable		 3hs6B-2c0kA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		4 PHE A 120
VAL A  31
VAL A  29
LEU A  28
 None
 0.83A 3hs6B-2c2qA:
undetectable		 3hs6B-2c2qA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A1267
VAL A1271
LEU A1274
VAL A1243
 None
 0.80A 3hs6B-2cfvA:
undetectable		 3hs6B-2cfvA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 VAL A 281
LEU A 288
SER A 289
VAL A 239
 None
 0.87A 3hs6B-2cvoA:
undetectable		 3hs6B-2cvoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 VAL A  89
VAL A  93
LEU A  96
SER A  97
 None
 0.53A 3hs6B-2dg8A:
undetectable		 3hs6B-2dg8A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		4 VAL A 118
VAL A 215
LEU A 259
SER A 258
 None
 0.75A 3hs6B-2ef4A:
undetectable		 3hs6B-2ef4A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Rattus
norvegicus) 		PF12796
(Ank_2) 		4 VAL A 184
VAL A 180
LEU A 177
SER A 176
 None
 0.71A 3hs6B-2etaA:
undetectable		 3hs6B-2etaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Homo sapiens) 		PF12796
(Ank_2) 		4 VAL A 183
VAL A 179
LEU A 176
SER A 175
 None
 0.74A 3hs6B-2f37A:
undetectable		 3hs6B-2f37A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		4 VAL A 150
VAL A 154
LEU A 157
SER A 158
 None
 0.80A 3hs6B-2f7nA:
undetectable		 3hs6B-2f7nA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
GAMMA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF04268
(SoxG) 		4 VAL C 186
VAL C 190
SER C 194
VAL C  28
 None
 0.92A 3hs6B-2gahC:
undetectable		 3hs6B-2gahC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		5 PHE A 187
VAL A 192
VAL A 163
LEU A 331
SER A 332
 None
 1.38A 3hs6B-2gfiA:
undetectable		 3hs6B-2gfiA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		5 PHE A 187
VAL A 192
VAL A 163
SER A 332
VAL A 171
 None
 1.24A 3hs6B-2gfiA:
undetectable		 3hs6B-2gfiA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		5 PHE A 275
VAL A 479
VAL A 483
LEU A 441
VAL A 453
 None
 1.40A 3hs6B-2gwcA:
undetectable		 3hs6B-2gwcA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		4 PHE A 533
VAL A 563
LEU A 566
SER A 567
 None
 0.88A 3hs6B-2hwkA:
undetectable		 3hs6B-2hwkA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i10 PUTATIVE TETR
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 VAL A 162
VAL A 166
LEU A 169
SER A 170
 None
 0.79A 3hs6B-2i10A:
undetectable		 3hs6B-2i10A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ill TITIN

(Homo sapiens) 		PF07679
(I-set) 		4 VAL A 151
LEU A 160
SER A 159
VAL A 176
 None
 0.84A 3hs6B-2illA:
undetectable		 3hs6B-2illA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 PHE A 934
VAL A 789
LEU A 796
SER A 795
 None
 0.82A 3hs6B-2ipcA:
1.4		 3hs6B-2ipcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 VAL A  68
VAL A 294
LEU A 260
SER A 261
TRP A 124
 None
MHO  A 292 ( 4.5A)
None
MHO  A 292 ( 3.9A)
None
 1.18A 3hs6B-2iqfA:
undetectable		 3hs6B-2iqfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		4 PHE A 193
VAL A 148
VAL A 152
LEU A 155
 None
 0.81A 3hs6B-2irwA:
undetectable		 3hs6B-2irwA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 VAL A 705
VAL A 701
SER A 697
VAL A 474
 None
None
None
ADP  A1723 (-3.7A)
 0.92A 3hs6B-2iuuA:
undetectable		 3hs6B-2iuuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 VAL A1222
VAL A1226
LEU A1229
VAL A1267
 None
 0.45A 3hs6B-2ix8A:
undetectable		 3hs6B-2ix8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh2 O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00963
(Cohesin) 		4 VAL A  98
VAL A  30
LEU A  14
SER A  13
 None
 0.80A 3hs6B-2jh2A:
undetectable		 3hs6B-2jh2A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lmr ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 1A

(Homo sapiens) 		PF07647
(SAM_2) 		4 PHE A  53
LEU A  90
SER A  89
VAL A  93
 None
 0.90A 3hs6B-2lmrA:
undetectable		 3hs6B-2lmrA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsm DNA-PACKAGING
PROTEIN FI

(Escherichia
virus Lambda) 		PF14000
(Packaging_FI) 		4 PHE A 113
VAL A  85
VAL A  83
LEU A  82
 None
 0.84A 3hs6B-2lsmA:
undetectable		 3hs6B-2lsmA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4n PROTEIN AFD-1,
ISOFORM A

(Caenorhabditis
elegans) 		PF00788
(RA) 		4 PHE A 100
VAL A  56
VAL A  54
LEU A  53
 None
 0.89A 3hs6B-2m4nA:
undetectable		 3hs6B-2m4nA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzi TITIN

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		4 VAL A 150
LEU A 159
SER A 158
VAL A 175
 None
 0.87A 3hs6B-2nziA:
undetectable		 3hs6B-2nziA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of3 ZYG-9

(Caenorhabditis
elegans) 		no annotation 4 VAL A 753
VAL A 757
LEU A 760
SER A 761
 None
 0.70A 3hs6B-2of3A:
undetectable		 3hs6B-2of3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5t PEZT

(Streptococcus
pneumoniae) 		PF06414
(Zeta_toxin) 		4 VAL B  98
VAL B 102
LEU B 105
SER B 106
 None
 0.73A 3hs6B-2p5tB:
undetectable		 3hs6B-2p5tB:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 VAL A 166
VAL A 170
LEU A 173
SER A 174
 None
 0.48A 3hs6B-2rgwA:
undetectable		 3hs6B-2rgwA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 VAL A1160
LEU A1152
TRP A1112
VAL A1028
 None
 0.91A 3hs6B-2rhpA:
0.7		 3hs6B-2rhpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1n O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00041
(fn3)
PF00963
(Cohesin) 		4 VAL A 865
VAL A 797
LEU A 781
SER A 780
 None
 0.79A 3hs6B-2w1nA:
undetectable		 3hs6B-2w1nA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 VAL A 155
VAL A 159
LEU A 162
VAL A 189
 None
 0.64A 3hs6B-2wnrA:
undetectable		 3hs6B-2wnrA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 VAL A 908
VAL A 970
LEU A1023
VAL A 983
 None
 0.83A 3hs6B-2x2iA:
undetectable		 3hs6B-2x2iA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		4 VAL A 277
VAL A 281
LEU A 284
SER A 285
 None
 0.92A 3hs6B-2x98A:
undetectable		 3hs6B-2x98A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 AP-2 COMPLEX SUBUNIT
BETA

(Homo sapiens) 		PF01602
(Adaptin_N) 		4 VAL B 177
VAL B 181
LEU B 184
SER B 185
 None
 0.86A 3hs6B-2xa7B:
undetectable		 3hs6B-2xa7B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xri ERI1 EXORIBONUCLEASE
3

(Homo sapiens) 		PF00929
(RNase_T) 		4 VAL A 224
VAL A 220
LEU A 217
SER A 216
 None
 0.86A 3hs6B-2xriA:
undetectable		 3hs6B-2xriA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 VAL A 565
VAL A 479
LEU A 587
SER A 586
 None
 0.86A 3hs6B-2xtlA:
undetectable		 3hs6B-2xtlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5j DIHYDROPTEROATE
SYNTHASE

(Burkholderia
cenocepacia) 		PF00809
(Pterin_bind) 		4 VAL A 272
VAL A 276
LEU A 279
SER A 280
 None
EDO  A1295 (-3.3A)
EDO  A1295 (-3.5A)
None
 0.80A 3hs6B-2y5jA:
undetectable		 3hs6B-2y5jA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 VAL A 212
VAL A 216
LEU A 219
VAL A 228
 None
 0.79A 3hs6B-2yijA:
undetectable		 3hs6B-2yijA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yiu CYTOCHROME B

(Paracoccus
denitrificans) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 VAL A 314
VAL A 318
LEU A 321
SER A 322
 None
 0.69A 3hs6B-2yiuA:
undetectable		 3hs6B-2yiuA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2b DIHYDROOROTASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 PHE A 146
VAL A 128
VAL A 163
LEU A 184
 None
 0.84A 3hs6B-2z2bA:
undetectable		 3hs6B-2z2bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		4 VAL A 314
VAL A 318
LEU A 321
SER A 322
 None
 0.89A 3hs6B-2z67A:
0.3		 3hs6B-2z67A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a64 CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 VAL A 126
VAL A 130
LEU A 133
SER A 134
 None
 0.90A 3hs6B-3a64A:
undetectable		 3hs6B-3a64A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bba INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10) 		4 VAL A 320
VAL A 318
LEU A 317
VAL A 112
 None
 0.87A 3hs6B-3bbaA:
undetectable		 3hs6B-3bbaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ble CITRAMALATE SYNTHASE
FROM LEPTOSPIRA
INTERROGANS

(Leptospira
interrogans) 		PF00682
(HMGL-like) 		4 VAL A 159
VAL A 163
LEU A 166
SER A 167
 None
 0.38A 3hs6B-3bleA:
undetectable		 3hs6B-3bleA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 PHE A 199
VAL A 228
VAL A 230
SER A 247
 None
 0.91A 3hs6B-3brqA:
undetectable		 3hs6B-3brqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		4 VAL A   4
VAL A   9
LEU A  12
VAL A 156
 None
 0.91A 3hs6B-3bxoA:
undetectable		 3hs6B-3bxoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		4 PHE B  91
LEU B  82
SER B  84
TRP B 125
 None
 0.86A 3hs6B-3cfiB:
undetectable		 3hs6B-3cfiB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		4 PHE B  91
LEU B  82
TRP B 125
VAL B 138
 None
 0.78A 3hs6B-3cfiB:
undetectable		 3hs6B-3cfiB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36

(Homo sapiens) 		PF04157
(EAP30) 		4 VAL B 273
VAL B 269
LEU B 266
SER B 265
 None
 0.83A 3hs6B-3cuqB:
undetectable		 3hs6B-3cuqB:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfu UNCHARACTERIZED
PROTEIN FROM
6-PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
FAMILY

(Corynebacterium
glutamicum) 		PF10727
(Rossmann-like) 		4 VAL A  53
VAL A  57
LEU A  60
SER A  61
 None
 0.71A 3hs6B-3dfuA:
undetectable		 3hs6B-3dfuA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3erw SPORULATION
THIOL-DISULFIDE
OXIDOREDUCTASE A

(Bacillus
subtilis) 		PF00578
(AhpC-TSA) 		5 PHE A  60
VAL A  92
VAL A  90
LEU A  89
VAL A  87
 None
 1.34A 3hs6B-3erwA:
undetectable		 3hs6B-3erwA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		4 VAL A 355
VAL A 359
LEU A 362
VAL A 406
 None
 0.83A 3hs6B-3ez1A:
undetectable		 3hs6B-3ez1A:
21.50