SIMILAR PATTERNS OF AMINO ACIDS FOR 3HS4_A_AZMA703_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 HIS B 360
TRP A 397
TRP A 401
ASP A 402
 None
 1.46A 3hs4A-1mu2B:
0.0		 3hs4A-1mu2B:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  84
TRP A  83
HIS A 126
ASP A  93
 None
 1.24A 3hs4A-4f7kA:
0.0		 3hs4A-4f7kA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		4 TRP A 270
HIS A 350
TRP A 279
ASP A 271
 None
 1.26A 3hs4A-4k90A:
0.0		 3hs4A-4k90A:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A   4
TRP A   5
HIS A  15
TRP A  16
ASP A  19
 None
 0.76A 3hs4A-4qk3A:
45.0		 3hs4A-4qk3A:
95.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 HIS A 303
TRP A 324
HIS A 321
ASP A 304
 None
 1.45A 3hs4A-4x0oA:
0.0		 3hs4A-4x0oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h ZINC FINGER PROTEIN
JACKDAW

(Arabidopsis
thaliana) 		PF00096
(zf-C2H2) 		4 HIS C 177
TRP C 174
TRP C 159
ASP C 173
 ZN  C 302 (-3.5A)
None
None
None
 1.46A 3hs4A-5b3hC:
0.0		 3hs4A-5b3hC:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		4 TRP X   4
HIS X  14
TRP X  15
ASP X  18
 None
ALY  X  17 ( 4.0A)
None
ALY  X  17 ( 4.2A)
 0.41A 3hs4A-5eztX:
44.6		 3hs4A-5eztX:
80.16