SIMILAR PATTERNS OF AMINO ACIDS FOR 3HM1_B_J3ZB1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 LEU A  39
MET A  23
LEU A  22
GLY A  75
HIS A  78
 None
 1.21A 3hm1B-1amyA:
undetectable		 3hm1B-1amyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1d PROTEIN (CAPSID
PROTEIN)

(Rous sarcoma
virus) 		PF00607
(Gag_p24) 		5 MET A  44
LEU A  48
LEU A 129
GLU A 128
MET A  57
 None
 1.18A 3hm1B-1d1dA:
undetectable		 3hm1B-1d1dA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 LEU A 779
LEU A 795
LEU A 716
GLY A 804
LEU A 803
 None
 1.35A 3hm1B-1kz7A:
1.5		 3hm1B-1kz7A:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 MET A 343
LEU A 346
LEU A 349
GLU A 353
MET A 388
LEU A 391
ARG A 394
MET A 421
GLY A 521
HIS A 524
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 ( 4.1A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
 0.42A 3hm1B-1pcgA:
38.2		 3hm1B-1pcgA:
98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 343
LEU A 346
LEU A 402
HIS A 524
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
None
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
 1.35A 3hm1B-1pcgA:
38.2		 3hm1B-1pcgA:
98.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		5 LEU A 264
LEU A  62
LEU A 117
GLY A  95
LEU A  46
 None
None
None
None
BME  A 301 (-4.4A)
 1.27A 3hm1B-1t8hA:
undetectable		 3hm1B-1t8hA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		5 LEU A 298
LEU A 295
LEU A 330
GLY A 254
LEU A 237
 None
 1.34A 3hm1B-1ujnA:
undetectable		 3hm1B-1ujnA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 141
MET A  93
GLY A  80
HIS A  77
LEU A  82
 None
 1.19A 3hm1B-1ukwA:
0.6		 3hm1B-1ukwA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00218
(IGPS) 		5 LEU A 133
GLU A 160
LEU A 138
GLY A 144
LEU A 147
 None
 1.40A 3hm1B-1vc4A:
undetectable		 3hm1B-1vc4A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		5 LEU A  75
GLU A  78
ARG A  88
GLY A 242
LEU A 248
 MPD  A3003 (-4.7A)
None
None
None
None
 1.20A 3hm1B-1wz8A:
undetectable		 3hm1B-1wz8A:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
LEU A 327
GLU A 331
ARG A 372
HIS A 494
 None
 0.58A 3hm1B-1xb7A:
28.7		 3hm1B-1xb7A:
32.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6v EMP46P

(Saccharomyces
cerevisiae) 		PF03388
(Lectin_leg-like) 		5 LEU A 175
LEU A 177
MET A 193
GLY A 113
LEU A 132
 None
 1.26A 3hm1B-2a6vA:
undetectable		 3hm1B-2a6vA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
DELTA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 MET C 257
LEU C 264
LEU B 237
GLY B 246
HIS C 320
 None
 1.31A 3hm1B-2bg9C:
undetectable		 3hm1B-2bg9C:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Pyrococcus
furiosus) 		PF01380
(SIS) 		5 MET A  51
LEU A  48
LEU A  45
LEU A 295
GLY A 194
 None
 1.13A 3hm1B-2cb0A:
undetectable		 3hm1B-2cb0A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 LEU A 350
GLU A 272
MET A 292
GLY A 236
LEU A 233
 None
CA  A1362 (-4.3A)
None
None
None
 1.38A 3hm1B-2clpA:
undetectable		 3hm1B-2clpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		5 MET A  51
LEU A  48
LEU A  45
LEU A 295
GLY A 194
 None
 1.07A 3hm1B-2e5fA:
undetectable		 3hm1B-2e5fA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf5 FADD PROTEIN

(Homo sapiens) 		PF00531
(Death)
PF01335
(DED) 		5 LEU A   8
LEU A   7
LEU A  67
GLY A  42
LEU A  43
 None
 1.28A 3hm1B-2gf5A:
undetectable		 3hm1B-2gf5A:
24.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 268
LEU A 271
GLU A 275
ARG A 316
HIS A 434
 OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.52A 3hm1B-2gpvA:
27.5		 3hm1B-2gpvA:
36.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isj BLUB

(Sinorhizobium
meliloti) 		PF00881
(Nitroreductase) 		5 GLU A  44
LEU A  70
ARG A  72
GLY A  52
HIS A  55
 None
 1.38A 3hm1B-2isjA:
undetectable		 3hm1B-2isjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		5 LEU A1229
LEU A1228
GLU A1224
GLY A1253
LEU A1249
 None
 1.32A 3hm1B-2ix8A:
undetectable		 3hm1B-2ix8A:
14.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 MET A 343
LEU A 346
LEU A 349
GLU A 353
MET A 388
LEU A 391
ARG A 394
MET A 421
GLY A 521
HIS A 524
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
 0.44A 3hm1B-2ocfA:
37.7		 3hm1B-2ocfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 343
LEU A 346
LEU A 402
GLY A 521
HIS A 524
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
 1.29A 3hm1B-2ocfA:
37.7		 3hm1B-2ocfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 GLU A 102
LEU A 230
ARG A 109
GLY A 236
LEU A 238
 None
 1.25A 3hm1B-2optA:
undetectable		 3hm1B-2optA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  32
LEU A  35
LEU A  77
ARG A  80
MET A 108
 1CA  A 247 (-4.0A)
1CA  A 247 ( 4.4A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
 0.37A 3hm1B-2q3yA:
28.5		 3hm1B-2q3yA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		5 MET A  63
LEU A  60
LEU A  57
LEU A  38
LEU A 365
 None
 1.08A 3hm1B-2vrkA:
undetectable		 3hm1B-2vrkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		5 MET A 261
LEU A 264
LEU A 267
LEU A 203
LEU A 231
 None
 1.24A 3hm1B-2wzmA:
undetectable		 3hm1B-2wzmA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 427
LEU A 551
GLY A 438
HIS A 437
LEU A 433
 None
 1.37A 3hm1B-2x3kA:
undetectable		 3hm1B-2x3kA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 LEU A  91
GLU A  89
ARG A 113
GLY A 309
LEU A 311
 None
 1.30A 3hm1B-2x5fA:
undetectable		 3hm1B-2x5fA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		5 LEU A 229
GLU A 233
LEU A 343
ARG A 310
LEU A 254
 HEM  A1359 (-4.5A)
None
HEM  A1359 (-4.6A)
HEM  A1359 (-4.0A)
None
 1.30A 3hm1B-2x66A:
undetectable		 3hm1B-2x66A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5y RIBOSE/GALACTOSE
ISOMERASE

(Novosphingobium
aromaticivorans) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		5 LEU A  55
LEU A  54
LEU A 207
GLY A  63
LEU A  60
 None
None
None
EDO  A 218 ( 3.8A)
None
 1.33A 3hm1B-3c5yA:
undetectable		 3hm1B-3c5yA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  39
GLU A  46
LEU A 101
ARG A 116
GLY A  75
 None
 1.32A 3hm1B-3dhvA:
undetectable		 3hm1B-3dhvA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di5 DINB-LIKE PROTEIN

(Bacillus cereus) 		PF05163
(DinB) 		5 LEU A  31
MET A  22
LEU A  23
GLY A 133
HIS A 131
 None
None
None
None
NI  A 168 (-3.5A)
 1.25A 3hm1B-3di5A:
undetectable		 3hm1B-3di5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 115
LEU A 165
MET A 128
LEU A 132
HIS A 120
 None
 1.24A 3hm1B-3e7oA:
undetectable		 3hm1B-3e7oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 5 LEU A 239
GLU A 209
GLY A  94
HIS A  92
LEU A  93
 None
 1.34A 3hm1B-3gjyA:
undetectable		 3hm1B-3gjyA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		5 LEU A 138
LEU A 175
GLU A 269
GLY A 153
LEU A 157
 None
 1.09A 3hm1B-3gkbA:
undetectable		 3hm1B-3gkbA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 LEU A 504
ARG A 232
MET A 531
GLY A 527
LEU A 481
 None
 1.29A 3hm1B-3hjrA:
undetectable		 3hm1B-3hjrA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib7 ICC PROTEIN

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		5 LEU A 108
GLU A 111
LEU A 118
ARG A 120
GLY A  68
 None
None
MPD  A 779 ( 4.9A)
MPD  A 779 (-4.4A)
BTB  A 777 ( 4.6A)
 1.35A 3hm1B-3ib7A:
undetectable		 3hm1B-3ib7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Burkholderia
mallei) 		PF00551
(Formyl_trans_N) 		5 LEU A 111
LEU A 120
LEU A 173
GLY A 126
LEU A 143
 None
 1.24A 3hm1B-3louA:
undetectable		 3hm1B-3louA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00579
(tRNA-synt_1b) 		5 MET A  36
LEU A   7
LEU A  13
MET A  25
GLY A  68
 None
 1.16A 3hm1B-3m5wA:
undetectable		 3hm1B-3m5wA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 GLU A 235
LEU A  13
ARG A   9
GLY A 265
LEU A 276
 None
 1.24A 3hm1B-3m6xA:
undetectable		 3hm1B-3m6xA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		5 LEU A 416
LEU A 499
LEU A 541
GLY A 412
LEU A 414
 None
 1.24A 3hm1B-3nz4A:
undetectable		 3hm1B-3nz4A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 GLU B 140
LEU B  96
ARG B 144
GLY B  84
HIS B  80
 None
 1.35A 3hm1B-3pz2B:
undetectable		 3hm1B-3pz2B:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF16823
(PilZ_2) 		5 LEU A 136
LEU A 126
LEU A 173
GLY A  50
LEU A  49
 None
 1.38A 3hm1B-3rqaA:
undetectable		 3hm1B-3rqaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 LEU A  32
LEU A  35
LEU A  77
ARG A  80
MET A 108
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
 0.34A 3hm1B-3ry9A:
28.1		 3hm1B-3ry9A:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		5 LEU A 328
LEU A 320
GLY A 302
HIS A 299
LEU A 300
 None
 1.39A 3hm1B-3tp9A:
undetectable		 3hm1B-3tp9A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		5 LEU A 350
MET A 306
LEU A 307
GLY A 376
LEU A 379
 None
 1.29A 3hm1B-3ujzA:
undetectable		 3hm1B-3ujzA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzz POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		5 LEU A 241
LEU A 253
LEU A 226
HIS A 236
LEU A 239
 None
 1.31A 3hm1B-3zzzA:
undetectable		 3hm1B-3zzzA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axs CARBAMATE KINASE

(Mycoplasma
penetrans) 		PF00696
(AA_kinase) 		5 MET A  88
GLU A  22
GLY A  10
HIS A  45
LEU A   8
 None
None
SO4  A1311 (-3.0A)
None
None
 1.30A 3hm1B-4axsA:
undetectable		 3hm1B-4axsA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3g DNA-BINDING PROTEIN
SMUBP-2

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 389
GLU A 382
MET A 423
LEU A 426
ARG A 425
 None
 1.33A 3hm1B-4b3gA:
undetectable		 3hm1B-4b3gA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR BETA
SUBUNIT
ACETYLCHOLINE
RECEPTOR DELTA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 MET C 257
LEU C 264
LEU B 237
GLY B 246
HIS C 320
 None
 1.31A 3hm1B-4booC:
undetectable		 3hm1B-4booC:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13

(Candida
albicans) 		PF09084
(NMT1) 		5 LEU A 125
GLU A 192
LEU A 193
GLY A  90
LEU A 185
 None
 1.39A 3hm1B-4eswA:
undetectable		 3hm1B-4eswA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewg BETA-KETOACYL
SYNTHASE

(Paraburkholderia
phymatum) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 187
LEU A 185
GLU A 241
ARG A 249
GLY A  10
 None
 1.15A 3hm1B-4ewgA:
undetectable		 3hm1B-4ewgA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8o TOXIN RNLA

(Escherichia
coli) 		PF15935
(RnlA_toxin) 		5 LEU A 117
LEU A 114
GLU A 110
ARG A 133
LEU A 179
 None
 1.31A 3hm1B-4i8oA:
2.2		 3hm1B-4i8oA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m98 PILIN GLYCOSYLATION
PROTEIN

(Neisseria
gonorrhoeae) 		PF00132
(Hexapep) 		5 MET A 308
LEU A 217
LEU A 202
GLY A 211
HIS A 210
 None
 1.24A 3hm1B-4m98A:
undetectable		 3hm1B-4m98A:
18.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 283
LEU A 286
GLU A 290
ARG A 331
MET A 358
GLY A 447
 None
 0.65A 3hm1B-4n1yA:
31.6		 3hm1B-4n1yA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 283
LEU A 286
MET A 321
MET A 358
LEU A 454
 None
 1.36A 3hm1B-4n1yA:
31.6		 3hm1B-4n1yA:
39.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA

(Klebsiella
pneumoniae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU H 363
LEU H 360
GLU H 571
GLY H 354
LEU H 353
 None
 1.29A 3hm1B-4nl4H:
undetectable		 3hm1B-4nl4H:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		5 LEU A 140
LEU A 121
MET A 103
GLY A  90
LEU A  92
 None
 1.39A 3hm1B-4pfrA:
undetectable		 3hm1B-4pfrA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 LEU B 631
LEU B 643
GLY B 653
HIS B 654
LEU B 651
 None
None
None
CLA  B9022 ( 4.0A)
CLA  B9022 (-3.5A)
 1.11A 3hm1B-4rkuB:
undetectable		 3hm1B-4rkuB:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 305
LEU A 286
ARG A 272
GLY A 162
LEU A 159
 None
None
None
None
VFV  A 580 (-4.5A)
 1.05A 3hm1B-4uhiA:
2.5		 3hm1B-4uhiA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		5 LEU A 772
LEU A 768
LEU A 699
GLY A 693
LEU A 571
 None
 1.29A 3hm1B-4uw2A:
undetectable		 3hm1B-4uw2A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		5 LEU A  38
LEU A  76
ARG A  47
GLY A  68
HIS A  63
 None
MPD  A 402 ( 4.1A)
MPD  A 402 (-4.3A)
None
None
 1.32A 3hm1B-4y0eA:
undetectable		 3hm1B-4y0eA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye9 GLUTAMINE--TRNA
LIGASE

(Homo sapiens) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2)
PF04558
(tRNA_synt_1c_R1) 		5 MET A 221
LEU A 224
LEU A 229
LEU A 455
GLY A 296
 None
 1.32A 3hm1B-4ye9A:
undetectable		 3hm1B-4ye9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5q CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		5 MET A 373
LEU A 369
LEU A 366
MET A 131
GLY A 126
 None
 1.36A 3hm1B-4z5qA:
2.3		 3hm1B-4z5qA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 LEU A  69
LEU A  71
LEU A  57
GLY A 139
LEU A 137
 None
 1.33A 3hm1B-5a3fA:
undetectable		 3hm1B-5a3fA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 LEU A 299
LEU A 300
LEU A 325
GLY A 358
LEU A 391
 None
 1.22A 3hm1B-5dboA:
undetectable		 3hm1B-5dboA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		5 LEU A 108
LEU A 107
MET A 187
GLY A 116
LEU A 113
 None
 1.19A 3hm1B-5djqA:
undetectable		 3hm1B-5djqA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyi NON-STRUCTURAL
PROTEIN 11

(Porcine
reproductive
and respiratory
syndrome virus) 		no annotation 5 LEU A 186
LEU A 183
GLU A 120
ARG A 107
MET A 201
 None
 1.15A 3hm1B-5eyiA:
undetectable		 3hm1B-5eyiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		5 LEU A 292
LEU A 331
LEU A 337
GLY A  85
LEU A  84
 None
 1.37A 3hm1B-5g56A:
undetectable		 3hm1B-5g56A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk9 BRD1 PROTEIN
HISTONE
ACETYLTRANSFERASE
KAT7

(Homo sapiens) 		PF01853
(MOZ_SAS)
no annotation 		5 MET A 564
LEU A 575
LEU A 573
GLU B  58
LEU A 531
 None
 1.05A 3hm1B-5gk9A:
undetectable		 3hm1B-5gk9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF12341
(Mcl1_mid) 		5 LEU A 604
LEU A 554
GLY A 616
HIS A 615
LEU A 614
 None
 1.32A 3hm1B-5gvbA:
undetectable		 3hm1B-5gvbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF12341
(Mcl1_mid) 		5 LEU A 604
LEU A 569
GLY A 616
HIS A 615
LEU A 614
 None
 1.31A 3hm1B-5gvbA:
undetectable		 3hm1B-5gvbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja4 TONSOKU-LIKE PROTEIN

(Homo sapiens) 		PF12796
(Ank_2) 		5 LEU D 617
LEU D 618
LEU D 606
GLY D 573
LEU D 575
 None
 1.29A 3hm1B-5ja4D:
undetectable		 3hm1B-5ja4D:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsz CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN

(Lactobacillus
delbrueckii) 		PF12822
(ECF_trnsprt) 		5 LEU C  19
LEU C  16
GLU C  12
GLY C  52
LEU C  54
 None
 1.20A 3hm1B-5jszC:
undetectable		 3hm1B-5jszC:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE

(Shewanella
oneidensis) 		PF00465
(Fe-ADH) 		5 GLU A 284
LEU A 352
ARG A 355
GLY A 255
HIS A 258
 None
None
None
None
ZN  A 407 (-3.5A)
 1.39A 3hm1B-5k8cA:
undetectable		 3hm1B-5k8cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la0 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		5 LEU A 165
LEU A 210
GLU A 167
LEU A 308
HIS A 163
 None
 1.36A 3hm1B-5la0A:
undetectable		 3hm1B-5la0A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		5 MET M 316
LEU M 238
LEU M 106
GLY M 242
LEU M 244
 None
 1.33A 3hm1B-5lc5M:
undetectable		 3hm1B-5lc5M:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lts RNA-DIRECTED RNA
POLYMERASE L

(Lymphocytic
choriomeningitis
mammarenavirus) 		PF17296
(ArenaCapSnatch) 		5 LEU A  45
LEU A  42
LEU A   7
MET A 151
LEU A  21
 None
 1.34A 3hm1B-5ltsA:
undetectable		 3hm1B-5ltsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 769
LEU A 772
LEU A 814
ARG A 817
MET A 845
 ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
 0.41A 3hm1B-5mwpA:
28.0		 3hm1B-5mwpA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 LEU B 191
MET B 201
LEU B 206
GLY B  46
LEU B  44
 None
 1.26A 3hm1B-5my0B:
undetectable		 3hm1B-5my0B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 5 LEU A 604
LEU A 554
GLY A 616
HIS A 615
LEU A 614
 None
 1.35A 3hm1B-5ogsA:
undetectable		 3hm1B-5ogsA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 5 LEU A 604
LEU A 569
GLY A 616
HIS A 615
LEU A 614
 None
 1.28A 3hm1B-5ogsA:
undetectable		 3hm1B-5ogsA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU b 628
LEU b 640
GLY b 650
HIS b 651
LEU b 648
 None
None
None
CLA  b1806 ( 4.0A)
None
 1.05A 3hm1B-5oy0b:
undetectable		 3hm1B-5oy0b:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4G, ISOFORM A

(Drosophila
melanogaster) 		PF01652
(IF4E)
no annotation 		5 LEU B 626
LEU B 629
GLU A 103
LEU A  72
LEU A 163
 None
 1.33A 3hm1B-5t47B:
undetectable		 3hm1B-5t47B:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 MET A 294
LEU A 298
LEU A 301
GLU A 305
MET A 340
LEU A 343
ARG A 346
 None
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
 1.41A 3hm1B-5toaA:
31.4		 3hm1B-5toaA:
57.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 295
LEU A 298
LEU A 301
GLU A 305
MET A 340
LEU A 343
ARG A 346
GLY A 472
HIS A 475
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 (-4.0A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 0.38A 3hm1B-5toaA:
31.4		 3hm1B-5toaA:
57.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 295
LEU A 298
LEU A 354
GLY A 472
HIS A 475
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
EST  A 601 (-4.0A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 1.32A 3hm1B-5toaA:
31.4		 3hm1B-5toaA:
57.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 559
LEU A 562
LEU A 604
ARG A 607
MET A 635
 486  A 801 (-4.7A)
486  A 801 ( 4.8A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 1.32A 3hm1B-5uc1A:
22.5		 3hm1B-5uc1A:
15.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  32
LEU A  35
LEU A  77
ARG A  80
MET A 108
 1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
 0.84A 3hm1B-5ufsA:
28.3		 3hm1B-5ufsA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 MET A  29
LEU A  35
LEU A  77
ARG A  80
MET A 108
 1TA  A 301 ( 2.9A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
 1.20A 3hm1B-5ufsA:
28.3		 3hm1B-5ufsA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 232
LEU A 254
GLY A 228
HIS A 225
LEU A 224
 None
 1.27A 3hm1B-5vcxA:
undetectable		 3hm1B-5vcxA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13

(Homo sapiens) 		PF01564
(Spermine_synth) 		5 LEU A 613
LEU A 615
GLU A 648
LEU A 637
GLY A 480
 None
 1.30A 3hm1B-5wcjA:
undetectable		 3hm1B-5wcjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xf7 PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS

(Homo sapiens) 		no annotation 5 LEU A 341
MET A 278
LEU A 279
GLY A 363
LEU A 367
 None
 1.34A 3hm1B-5xf7A:
undetectable		 3hm1B-5xf7A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 MET C1403
LEU C1406
MET C1369
HIS C1418
LEU C1419
 None
 1.18A 3hm1B-5y3rC:
undetectable		 3hm1B-5y3rC:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apg DISD PROTEIN

(Sorangium
cellulosum) 		no annotation 5 LEU A  87
ARG A 111
MET A  16
GLY A 265
HIS A 266
 None
MLI  A 301 (-3.3A)
None
None
SO4  A 303 (-3.8A)
 1.34A 3hm1B-6apgA:
undetectable		 3hm1B-6apgA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck9 GP41 ECTODOMAIN OF
ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 5 LEU B 646
LEU B 645
GLU B 648
GLY B 594
LEU B 592
 None
 1.36A 3hm1B-6ck9B:
undetectable		 3hm1B-6ck9B:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 482
LEU A 483
GLU A 510
LEU A 502
GLY A 464
 None
 1.24A 3hm1B-6emkA:
undetectable		 3hm1B-6emkA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et0 PQSB

(Pseudomonas
aeruginosa) 		no annotation 5 LEU B 107
GLU B 225
LEU B 148
GLY B  61
LEU B  98
 None
 1.38A 3hm1B-6et0B:
undetectable		 3hm1B-6et0B:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et0 PQSB

(Pseudomonas
aeruginosa) 		no annotation 5 LEU B 143
LEU B 133
LEU B 176
GLY B  22
LEU B  17
 None
None
None
None
CSO  B  16 ( 3.8A)
 1.34A 3hm1B-6et0B:
undetectable		 3hm1B-6et0B:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc3 CAP-ASSOCIATED
PROTEIN CAF20
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B   9
LEU B  12
GLU A  72
LEU A  39
LEU A 131
 None
 1.31A 3hm1B-6fc3B:
undetectable		 3hm1B-6fc3B:
13.04