SIMILAR PATTERNS OF AMINO ACIDS FOR 3HM1_A_J3ZA2_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Rattus rattus) 		PF01242
(PTPS) 		5 ALA A  82
GLU A  81
LEU A 120
MET A  70
LEU A 126
 None
 1.16A 3hm1A-1b66A:
undetectable		 3hm1A-1b66A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fim MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Rattus
norvegicus) 		PF01187
(MIF) 		5 THR A  30
ALA A  29
LEU A  79
LEU A  78
LEU A  61
 None
 1.17A 3hm1A-1fimA:
undetectable		 3hm1A-1fimA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ALA A 226
GLU A 229
LEU A 212
LEU A 186
LEU A 183
 None
 1.15A 3hm1A-1iqrA:
undetectable		 3hm1A-1iqrA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 LEU A  75
ALA A  73
LEU A 106
LEU A 103
LEU A 101
 None
 1.11A 3hm1A-1mb9A:
undetectable		 3hm1A-1mb9A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mum 2-METHYLISOCITRATE
LYASE

(Escherichia
coli) 		PF13714
(PEP_mutase) 		5 LEU A  83
ALA A  41
LEU A  14
LEU A  20
MET A 156
 None
 1.15A 3hm1A-1mumA:
undetectable		 3hm1A-1mumA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvl PPC DECARBOXYLASE
ATHAL3A

(Arabidopsis
thaliana) 		PF02441
(Flavoprotein) 		5 LEU A  23
ALA A  25
LEU A 122
LEU A 121
LEU A 135
 None
 1.03A 3hm1A-1mvlA:
undetectable		 3hm1A-1mvlA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 MET X 538
GLU X 547
LEU X 486
ARG X 168
LEU X 203
 None
 1.14A 3hm1A-1mw9X:
undetectable		 3hm1A-1mw9X:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		5 LEU A 141
ALA A 139
LEU A  73
LEU A  77
LEU A  78
 None
 0.99A 3hm1A-1mxfA:
undetectable		 3hm1A-1mxfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C) 		5 MET A 211
LEU E 956
THR E 955
LEU E 914
LEU E 903
 None
 0.72A 3hm1A-1o7dA:
undetectable		 3hm1A-1o7dA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 5 LEU A  27
THR A  28
ALA A  31
LEU A 211
MET A 137
 None
 0.78A 3hm1A-1oy1A:
undetectable		 3hm1A-1oy1A:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 346
THR A 347
ALA A 350
GLU A 353
LEU A 384
LEU A 387
LEU A 391
ARG A 394
MET A 421
LEU A 525
 EST  A   1 (-4.4A)
None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 (-3.6A)
 0.45A 3hm1A-1pcgA:
37.7		 3hm1A-1pcgA:
98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 MET A 342
LEU A 346
ALA A 350
GLU A 353
LEU A 387
LEU A 391
ARG A 394
 None
EST  A   1 (-4.4A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
 1.24A 3hm1A-1pcgA:
37.7		 3hm1A-1pcgA:
98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
LEU A 346
THR A 347
ALA A 350
GLU A 353
LEU A 384
LEU A 387
LEU A 391
ARG A 394
MET A 421
 EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.62A 3hm1A-1pcgA:
37.7		 3hm1A-1pcgA:
98.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 LEU A 142
ALA A 129
LEU A 147
LEU A 110
MET A 109
 None
 1.16A 3hm1A-1rzmA:
undetectable		 3hm1A-1rzmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc7 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Escherichia
coli) 		PF13899
(Thioredoxin_7) 		5 LEU A  66
ALA A  68
LEU A  84
LEU A  80
LEU A  93
 None
 1.14A 3hm1A-1uc7A:
undetectable		 3hm1A-1uc7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugo BCL2-ASSOCIATED
ATHANOGENE 5

(Mus musculus) 		PF02179
(BAG) 		5 ALA A  79
GLU A  83
LEU A  57
LEU A  53
LEU A  20
 None
 1.08A 3hm1A-1ugoA:
undetectable		 3hm1A-1ugoA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiz MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Xenopus laevis) 		PF01187
(MIF) 		5 THR A  30
ALA A  29
LEU A  79
LEU A  78
LEU A  61
 None
 1.15A 3hm1A-1uizA:
undetectable		 3hm1A-1uizA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usw FERULOYL ESTERASE A

(Aspergillus
niger) 		PF01764
(Lipase_3) 		5 MET A 138
LEU A 141
THR A 142
ALA A 144
LEU A  88
 None
 1.17A 3hm1A-1uswA:
undetectable		 3hm1A-1uswA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		5 LEU A  59
ALA A 242
LEU A 257
LEU A 258
LEU A  10
 None
 1.09A 3hm1A-1y9uA:
undetectable		 3hm1A-1y9uA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6n HYPOTHETICAL PROTEIN
PA1234

(Pseudomonas
aeruginosa) 		PF14595
(Thioredoxin_9) 		5 LEU A  76
ALA A  79
LEU A  45
LEU A 151
LEU A 159
 None
 1.04A 3hm1A-1z6nA:
undetectable		 3hm1A-1z6nA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 LEU A 246
ALA A 250
LEU A 198
LEU A 170
LEU A 173
 None
 1.06A 3hm1A-1zklA:
1.8		 3hm1A-1zklA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bap DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		no annotation 5 MET B 266
ALA B 273
GLU B 276
LEU B 233
LEU B 254
 None
 1.12A 3hm1A-2bapB:
undetectable		 3hm1A-2bapB:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		5 THR A 257
ALA A 260
LEU A 305
LEU A 272
MET A 280
 None
 1.03A 3hm1A-2bxyA:
undetectable		 3hm1A-2bxyA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 LEU A  57
ALA A  60
LEU A  19
LEU A  21
LEU A 110
 None
 1.04A 3hm1A-2dg8A:
undetectable		 3hm1A-2dg8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		5 LEU A  99
GLU A 106
LEU A 161
LEU A 169
LEU A 157
 None
 1.05A 3hm1A-2f1sA:
undetectable		 3hm1A-2f1sA:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 268
ALA A 272
GLU A 275
LEU A 309
ARG A 316
 OHT  A 500 (-4.1A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
 0.49A 3hm1A-2gpvA:
27.8		 3hm1A-2gpvA:
36.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 THR A 456
LEU A 346
LEU A 347
LEU A 452
MET A 495
 None
 1.14A 3hm1A-2h8hA:
undetectable		 3hm1A-2h8hA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6g PUTATIVE
METHYLTRANSFERASE

(Salmonella
enterica) 		PF03848
(TehB) 		5 LEU A  23
ALA A  25
LEU A 100
LEU A 131
LEU A  48
 None
MLY  A 167 ( 4.2A)
None
None
None
 1.16A 3hm1A-2i6gA:
undetectable		 3hm1A-2i6gA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwa GLUTAMINE
CYCLOTRANSFERASE

(Carica papaya) 		PF05096
(Glu_cyclase_2) 		5 LEU A  56
THR A  55
ALA A  51
LEU A 100
LEU A  95
 None
 1.11A 3hm1A-2iwaA:
undetectable		 3hm1A-2iwaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kr0 PROTEASOMAL
UBIQUITIN RECEPTOR
ADRM1

(Homo sapiens) 		PF04683
(Proteasom_Rpn13)
PF16550
(RPN13_C) 		5 LEU A 347
ALA A 345
LEU A 310
LEU A 340
MET A 356
 None
 1.12A 3hm1A-2kr0A:
undetectable		 3hm1A-2kr0A:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 MET A 343
LEU A 346
THR A 347
ALA A 350
GLU A 353
LEU A 384
LEU A 387
LEU A 391
ARG A 394
MET A 421
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 (-3.6A)
 0.47A 3hm1A-2ocfA:
37.5		 3hm1A-2ocfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  32
ALA A  36
LEU A  77
ARG A  80
MET A 108
 1CA  A 247 (-4.0A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
 0.44A 3hm1A-2q3yA:
29.0		 3hm1A-2q3yA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 LEU A  31
THR A  27
ALA A  29
LEU A 366
LEU A  20
 None
 1.11A 3hm1A-2v7gA:
undetectable		 3hm1A-2v7gA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		5 LEU A  23
ALA A  25
LEU A 100
LEU A 131
LEU A  48
 None
 1.13A 3hm1A-2xvaA:
undetectable		 3hm1A-2xvaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER

(Pseudomonas
putida) 		PF16591
(HBM) 		5 ALA A  62
LEU A  83
LEU A  56
LEU A 120
MET A 123
 None
 1.09A 3hm1A-2yfbA:
undetectable		 3hm1A-2yfbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ALA A   7
LEU A  25
LEU A   5
LEU A   4
LEU A  53
 None
 1.11A 3hm1A-2yzmA:
undetectable		 3hm1A-2yzmA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A 460
LEU A 452
LEU A 453
LEU A 497
LEU A 770
 None
 1.12A 3hm1A-2znsA:
undetectable		 3hm1A-2znsA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		5 MET A 520
LEU A 523
THR A 524
LEU A 537
LEU A 513
 None
 1.09A 3hm1A-3a5iA:
undetectable		 3hm1A-3a5iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 LEU A 187
THR A 188
ALA A 191
GLU A 194
LEU A  94
 None
 1.07A 3hm1A-3b4wA:
undetectable		 3hm1A-3b4wA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 LEU A 187
THR A 188
ALA A 191
LEU A  89
LEU A  94
 None
 1.10A 3hm1A-3b4wA:
undetectable		 3hm1A-3b4wA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF03061
(4HBT) 		5 LEU A  20
LEU A 108
LEU A 105
LEU A 101
LEU A  83
 None
 1.02A 3hm1A-3e8pA:
undetectable		 3hm1A-3e8pA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY

(Novosphingobium
aromaticivorans) 		PF08445
(FR47) 		6 LEU A  29
ALA A  40
LEU A 223
LEU A  63
ARG A   9
LEU A  54
 None
 1.25A 3hm1A-3ec4A:
undetectable		 3hm1A-3ec4A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 MET B 266
ALA B 273
GLU B 276
LEU B 233
LEU B 254
 None
 1.15A 3hm1A-3eg5B:
undetectable		 3hm1A-3eg5B:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		5 THR A 173
ALA A 177
LEU A 233
LEU A 241
LEU A 151
 None
 1.12A 3hm1A-3ez6A:
undetectable		 3hm1A-3ez6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE

(Methanosarcina
mazei) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 MET A 336
LEU A 339
THR A 340
ALA A 343
GLU A 345
 None
 1.16A 3hm1A-3g79A:
undetectable		 3hm1A-3g79A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		5 THR A 139
ALA A  32
LEU A   4
LEU A   7
LEU A  11
 None
 1.14A 3hm1A-3gseA:
undetectable		 3hm1A-3gseA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		5 THR A 214
ALA A 217
LEU A  25
LEU A  22
LEU A 264
 None
 1.07A 3hm1A-3h74A:
undetectable		 3hm1A-3h74A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		5 LEU A 133
ALA A 136
GLU A 135
LEU A 170
LEU A  94
 None
 1.14A 3hm1A-3kn1A:
undetectable		 3hm1A-3kn1A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 GASTRIC INTRINSIC
FACTOR

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		5 LEU A  94
THR A  95
ALA A  98
LEU A  75
LEU A  58
 None
 1.07A 3hm1A-3kq4A:
undetectable		 3hm1A-3kq4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2h PUTATIVE SUGAR
PHOSPHATE ISOMERASE

(Acidithiobacillus
ferrooxidans) 		PF07883
(Cupin_2) 		6 GLU A  12
LEU A  36
LEU A   8
LEU A   7
ARG A   4
LEU A  49
 None
None
None
None
None
CXS  A 164 (-4.4A)
 1.49A 3hm1A-3l2hA:
undetectable		 3hm1A-3l2hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 226
THR A 225
ALA A  41
LEU A 259
LEU A   9
 None
 1.16A 3hm1A-3ljpA:
undetectable		 3hm1A-3ljpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1g PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Corynebacterium
glutamicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 ALA A 219
GLU A 192
ARG A 199
LEU A 273
MET A 270
 None
 1.15A 3hm1A-3m1gA:
undetectable		 3hm1A-3m1gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 5 LEU B 370
ALA B 374
LEU B 405
LEU B 347
LEU B 431
 None
 1.11A 3hm1A-3ogkB:
undetectable		 3hm1A-3ogkB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p52 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Campylobacter
jejuni) 		PF02540
(NAD_synthase) 		5 LEU A 205
LEU A 216
LEU A 219
LEU A 223
MET A 231
 None
 1.09A 3hm1A-3p52A:
undetectable		 3hm1A-3p52A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl0 UNCHARACTERIZED
PROTEIN

(Methylibium
petroleiphilum) 		PF10014
(2OG-Fe_Oxy_2) 		5 LEU A 240
ALA A 173
LEU A 126
LEU A 123
MET A  45
 None
 1.05A 3hm1A-3pl0A:
undetectable		 3hm1A-3pl0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A  47
LEU A  39
LEU A  40
LEU A  84
LEU A 236
 None
 1.07A 3hm1A-3u92A:
undetectable		 3hm1A-3u92A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		5 ALA A 379
GLU A 382
LEU A 392
LEU A 389
LEU A 178
 None
 1.10A 3hm1A-3zlbA:
undetectable		 3hm1A-3zlbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 THR B 306
ALA B 309
LEU A  67
LEU A  74
MET B 430
 None
None
None
None
S35  A1259 ( 4.6A)
 1.00A 3hm1A-4az3B:
undetectable		 3hm1A-4az3B:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 LEU A 467
LEU A 433
LEU A 436
LEU A 440
LEU A 473
 None
 0.91A 3hm1A-4b8jA:
undetectable		 3hm1A-4b8jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU A 467
LEU A 433
LEU A 436
LEU A 440
LEU A 473
 None
 1.06A 3hm1A-4bplA:
undetectable		 3hm1A-4bplA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		6 LEU A  10
THR A  74
ALA A  73
LEU A   7
LEU A  69
MET A  52
 None
 1.30A 3hm1A-4dimA:
undetectable		 3hm1A-4dimA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqk BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 THR A 716
GLU A 806
LEU A 756
LEU A 802
LEU A 751
 None
 1.05A 3hm1A-4dqkA:
undetectable		 3hm1A-4dqkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 LEU B 258
ALA B 256
LEU B 248
LEU B 251
LEU B 271
 None
 1.04A 3hm1A-4hdsB:
undetectable		 3hm1A-4hdsB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 LEU M  76
THR M  77
GLU M 103
LEU M  84
MET M 443
 None
 1.03A 3hm1A-4heaM:
undetectable		 3hm1A-4heaM:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 THR A 456
LEU A 346
LEU A 347
LEU A 452
MET A 495
 None
 1.14A 3hm1A-4k11A:
undetectable		 3hm1A-4k11A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1g PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Bacillus cereus) 		PF01522
(Polysacc_deac_1) 		5 THR A  78
ALA A 102
LEU A 239
LEU A  95
LEU A  92
 None
 1.14A 3hm1A-4l1gA:
undetectable		 3hm1A-4l1gA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 THR A 306
ALA A 309
LEU A  67
LEU A  74
MET A 430
 THR  A 306 ( 0.8A)
ALA  A 309 ( 0.0A)
LEU  A  67 ( 0.5A)
LEU  A  74 ( 0.6A)
MET  A 430 ( 0.0A)
 1.16A 3hm1A-4mwtA:
undetectable		 3hm1A-4mwtA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 283
ALA A 287
GLU A 290
LEU A 324
ARG A 331
MET A 358
 None
 0.73A 3hm1A-4n1yA:
32.1		 3hm1A-4n1yA:
39.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 304
LEU A  71
LEU A  44
LEU A  49
LEU A  35
 None
 1.11A 3hm1A-4nf2A:
undetectable		 3hm1A-4nf2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		no annotation 5 LEU A 263
THR A 262
ALA A 261
LEU A 152
LEU A 189
 None
 1.04A 3hm1A-4po6A:
undetectable		 3hm1A-4po6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfv ANK-N5C-281

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A  10
ALA A  12
LEU A  25
LEU A  24
LEU A  57
 None
 1.12A 3hm1A-4qfvA:
undetectable		 3hm1A-4qfvA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Arthrobacter
sp. FB24) 		PF13377
(Peripla_BP_3) 		5 LEU A 301
GLU A 303
LEU A 331
ARG A 334
LEU A 152
 None
 1.04A 3hm1A-4rkrA:
undetectable		 3hm1A-4rkrA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3

(Homo sapiens) 		PF10421
(OAS1_C) 		5 LEU A 232
THR A 233
ALA A 236
LEU A 345
LEU A 353
 None
 1.06A 3hm1A-4s3nA:
undetectable		 3hm1A-4s3nA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2x IMPORTIN SUBUNIT
ALPHA-6

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU D 479
LEU D 445
LEU D 448
LEU D 452
LEU D 485
 None
 1.02A 3hm1A-4u2xD:
undetectable		 3hm1A-4u2xD:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU A 476
LEU A 442
LEU A 445
LEU A 449
LEU A 482
 None
 1.00A 3hm1A-4uadA:
undetectable		 3hm1A-4uadA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 769
ALA A 773
LEU A 810
LEU A 814
ARG A 817
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.5A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
 0.48A 3hm1A-4udbA:
28.2		 3hm1A-4udbA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylq COAGULATION FACTOR
VII

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU H  46
THR H  45
LEU H 105
LEU H 106
LEU H 108
 None
 1.09A 3hm1A-4ylqH:
undetectable		 3hm1A-4ylqH:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.14A 3hm1A-4zfhA:
undetectable		 3hm1A-4zfhA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		5 MET A 198
ALA A 191
GLU A 190
LEU A  75
LEU A  74
 None
 0.98A 3hm1A-4zz7A:
undetectable		 3hm1A-4zz7A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 5 MET A 233
LEU A 236
THR A 237
LEU A 149
LEU A 246
 None
None
OAQ  A 302 (-3.8A)
None
None
 1.15A 3hm1A-5bykA:
undetectable		 3hm1A-5bykA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		5 LEU A 164
THR A 163
ALA A 162
LEU A 261
LEU A 259
 None
 1.12A 3hm1A-5ddsA:
undetectable		 3hm1A-5ddsA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 LEU A 155
THR A 154
ALA A 157
LEU A 118
LEU A 115
 ADP  A 401 (-3.8A)
ADP  A 401 (-3.5A)
None
None
None
 1.16A 3hm1A-5eqtA:
undetectable		 3hm1A-5eqtA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN

(Yersinia pestis) 		PF00149
(Metallophos) 		5 LEU A 303
THR A  63
ALA A  64
LEU A 115
LEU A  40
 None
 1.15A 3hm1A-5eqvA:
undetectable		 3hm1A-5eqvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvv MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Homo sapiens) 		PF01187
(MIF) 		5 THR A  30
ALA A  29
LEU A  79
LEU A  78
LEU A  61
 None
 1.13A 3hm1A-5hvvA:
undetectable		 3hm1A-5hvvA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixd TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 LEU A 274
THR A 273
ALA A 272
LEU A 158
LEU A 195
 None
 1.06A 3hm1A-5ixdA:
undetectable		 3hm1A-5ixdA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le4 DD_D12_11_D12

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.10A 3hm1A-5le4A:
undetectable		 3hm1A-5le4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.06A 3hm1A-5lebA:
undetectable		 3hm1A-5lebA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw2 DARPIN_5M3_D12

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.13A 3hm1A-5lw2A:
undetectable		 3hm1A-5lw2A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0o TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE

(Jeotgalicoccus
sp. ATCC 8456) 		PF00067
(p450) 		5 THR A 147
ALA A 150
LEU A 197
LEU A 240
MET A 166
 None
 1.08A 3hm1A-5m0oA:
2.2		 3hm1A-5m0oA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH

(Staphylococcus
capitis) 		PF01566
(Nramp) 		5 THR A 123
ALA A 126
LEU A 385
LEU A 384
LEU A 392
 None
 1.11A 3hm1A-5m95A:
undetectable		 3hm1A-5m95A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 769
ALA A 773
LEU A 814
ARG A 817
MET A 845
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.8A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
 0.48A 3hm1A-5mwpA:
28.3		 3hm1A-5mwpA:
14.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 298
THR A 299
ALA A 302
GLU A 305
LEU A 339
LEU A 343
ARG A 346
LEU A 476
 EST  A 601 (-4.1A)
None
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 (-3.5A)
 0.44A 3hm1A-5toaA:
31.8		 3hm1A-5toaA:
57.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 MET A 295
LEU A 298
THR A 299
ALA A 302
GLU A 305
LEU A 339
LEU A 343
ARG A 346
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
 0.47A 3hm1A-5toaA:
31.8		 3hm1A-5toaA:
57.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 LEU A 439
THR A 440
ALA A 482
LEU A 488
LEU A 425
 None
 1.10A 3hm1A-5tw7A:
undetectable		 3hm1A-5tw7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 5 LEU A 235
THR A 236
ALA A 216
LEU A 232
LEU A 255
 None
 0.95A 3hm1A-5v2dA:
undetectable		 3hm1A-5v2dA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN

(Human
betaherpesvirus
5;
Lama glama) 		no annotation 5 THR A 252
LEU A 273
LEU A 269
LEU A 248
MET A 193
 None
 1.15A 3hm1A-5wb1A:
undetectable		 3hm1A-5wb1A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A  50
ALA A  52
LEU A  65
LEU A  64
LEU A  98
 LEU  A  50 ( 0.6A)
ALA  A  52 ( 0.0A)
LEU  A  65 ( 0.5A)
LEU  A  64 ( 0.6A)
LEU  A  98 ( 0.6A)
 1.10A 3hm1A-5wo6A:
undetectable		 3hm1A-5wo6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		no annotation 5 THR A 159
ALA A 160
LEU A 153
LEU A 148
LEU A 226
 None
 0.97A 3hm1A-6d2kA:
undetectable		 3hm1A-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5e DD_D12_10_47

(synthetic
construct) 		no annotation 5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.05A 3hm1A-6f5eA:
undetectable		 3hm1A-6f5eA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 LEU A  87
THR A  88
ALA A  91
LEU A  26
LEU A  27
 None
 1.14A 3hm1A-6fikA:
undetectable		 3hm1A-6fikA:
15.42