SIMILAR PATTERNS OF AMINO ACIDS FOR 3HLW_B_CE3B304_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 ASN A 652
THR A 392
SER A 660
ARG A 390
 None
 1.38A 3hlwB-1a2vA:
undetectable		 3hlwB-1a2vA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		4 ASN A  58
THR A 115
SER A  67
ARG A 119
 None
None
NA  A 623 (-3.3A)
GOL  A 625 (-4.9A)
 1.41A 3hlwB-1bg4A:
0.0		 3hlwB-1bg4A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cd1 CD1

(Mus musculus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 THR A  78
SER A  16
SER A  28
ARG A  74
 None
 1.39A 3hlwB-1cd1A:
0.0		 3hlwB-1cd1A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ASN A 387
THR A  47
SER A  49
SER A 115
 None
 1.25A 3hlwB-1ezvA:
0.0		 3hlwB-1ezvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A 457
SER A 504
SER A 506
ARG A 488
 None
 1.42A 3hlwB-1fcpA:
undetectable		 3hlwB-1fcpA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mje BREAST CANCER 2

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		4 ASN A2587
THR A2434
SER A2436
ARG A2441
 None
 1.20A 3hlwB-1mjeA:
undetectable		 3hlwB-1mjeA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkp PYST1

(Homo sapiens) 		PF00782
(DSPc) 		4 THR A 302
SER A 300
SER A 293
ARG A 299
 MPD  A 501 ( 4.2A)
None
CL  A 500 (-3.0A)
CL  A 500 (-4.6A)
 1.38A 3hlwB-1mkpA:
undetectable		 3hlwB-1mkpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASN A 280
THR A 516
SER A 503
ARG A 545
 None
 1.33A 3hlwB-1qhoA:
undetectable		 3hlwB-1qhoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ASN A 418
THR A 348
SER A 414
ARG A 337
 None
 1.46A 3hlwB-1uypA:
0.0		 3hlwB-1uypA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		4 ASN A  32
THR A  15
SER A  79
ARG A  77
 None
 1.48A 3hlwB-1wcgA:
undetectable		 3hlwB-1wcgA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7o ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Streptococcus
pneumoniae) 		PF00574
(CLP_protease) 		4 ASN A  80
THR A  99
SER A 103
SER A 158
 None
 1.18A 3hlwB-1y7oA:
undetectable		 3hlwB-1y7oA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		4 ASN A 244
THR A  37
SER A   8
SER A  10
 None
 1.43A 3hlwB-1ztvA:
undetectable		 3hlwB-1ztvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btl INFECTIOUS
BRONCHITIS VIRUS
NUCLEOCAPSID PROTEIN

(Avian
coronavirus) 		PF00937
(Corona_nucleoca) 		4 ASN A  59
SER A 127
SER A 125
ARG A 126
 None
 1.45A 3hlwB-2btlA:
undetectable		 3hlwB-2btlA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 ASN A 193
THR A 124
SER A  99
SER A  45
 ACT  A1313 ( 3.1A)
None
FMN  A1312 ( 4.5A)
None
 1.32A 3hlwB-2bx7A:
undetectable		 3hlwB-2bx7A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		4 ASN A 275
SER A 299
SER A 301
ARG A 304
 None
 1.28A 3hlwB-2o5rA:
undetectable		 3hlwB-2o5rA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5
REGULATOR OF
G-PROTEIN SIGNALING
9

(Mus musculus) 		PF00400
(WD40)
PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma) 		4 ASN A 198
THR B 348
SER B 344
ARG B 350
 None
 1.02A 3hlwB-2pbiA:
undetectable		 3hlwB-2pbiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE

(Agrobacterium
fabrum) 		PF03562
(MltA)
PF06725
(3D) 		4 ASN A 253
THR A 323
SER A 325
ARG A 289
 None
 1.45A 3hlwB-2pnwA:
undetectable		 3hlwB-2pnwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xbl PHOSPHOHEPTOSE
ISOMERASE

(Burkholderia
pseudomallei) 		PF13580
(SIS_2) 		4 ASN A 130
THR A 171
SER A 123
ARG A 152
 None
M7P  A1198 (-3.7A)
M7P  A1198 (-2.6A)
None
 1.34A 3hlwB-2xblA:
undetectable		 3hlwB-2xblA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		4 THR A 235
SER A 244
SER A 216
ARG A 212
 None
None
None
SO4  A 401 (-3.7A)
 1.18A 3hlwB-2zzrA:
undetectable		 3hlwB-2zzrA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab0 ANTIBODY SCFV
FRAGMENT, HEAVY
CHAIN
BCLA PROTEIN

(Bacillus
anthracis;
Mus musculus) 		PF07686
(V-set)
no annotation 		4 ASN B  73
THR B  57
SER B  52
SER A 119
 None
 1.27A 3hlwB-3ab0B:
undetectable		 3hlwB-3ab0B:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 ASN A 581
THR A 557
SER A 513
SER A 603
 None
 1.47A 3hlwB-3bdlA:
undetectable		 3hlwB-3bdlA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ASN A 436
SER A 174
SER A 232
ARG A 216
 CL  A   7 (-4.3A)
None
None
None
 1.38A 3hlwB-3bgaA:
undetectable		 3hlwB-3bgaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ASN A 412
SER A 150
SER A 208
ARG A 192
 None
 1.37A 3hlwB-3decA:
undetectable		 3hlwB-3decA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb8 CYSTEINE
PROTEASE-LIKE VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		4 ASN A 316
THR A 365
SER A 346
SER A 276
 None
 1.37A 3hlwB-3eb8A:
undetectable		 3hlwB-3eb8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT F

(Saccharomyces
cerevisiae) 		PF01990
(ATP-synt_F) 		4 ASN N  55
SER N  83
SER N 107
ARG N 111
 None
 1.28A 3hlwB-3j9tN:
undetectable		 3hlwB-3j9tN:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 ASN F 615
THR F 503
SER F 621
ARG F 501
 NAG  F1203 (-2.8A)
None
None
None
 1.42A 3hlwB-3jbrF:
undetectable		 3hlwB-3jbrF:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Brucella
abortus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASN A 274
THR A  64
SER A  62
SER A  84
 None
 1.44A 3hlwB-3k5pA:
undetectable		 3hlwB-3k5pA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 ASN A 316
THR A  81
SER A  83
SER A 242
 None
None
MLI  A 341 (-2.5A)
MLI  A 341 (-2.7A)
 1.35A 3hlwB-3l6cA:
undetectable		 3hlwB-3l6cA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		4 ASN A 316
THR A  81
SER A  83
SER A 242
 None
None
MLI  A 347 (-2.5A)
MLI  A 347 (-3.2A)
 1.38A 3hlwB-3l6rA:
undetectable		 3hlwB-3l6rA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		4 ASN A  55
THR A 331
SER A 295
SER A 305
 None
 1.32A 3hlwB-3ldfA:
undetectable		 3hlwB-3ldfA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lub PUTATIVE CREATININE
AMIDOHYDROLASE

(Bacteroides
fragilis) 		PF02633
(Creatininase) 		4 ASN A   2
SER A  59
SER A  61
ARG A  60
 None
 1.15A 3hlwB-3lubA:
undetectable		 3hlwB-3lubA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maz SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 1

(Homo sapiens) 		PF00017
(SH2) 		4 THR A 214
SER A 212
SER A 206
ARG A 184
 None
 1.39A 3hlwB-3mazA:
undetectable		 3hlwB-3mazA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2q SEX PHEROMONE
STAPH-CAM373

(Bacillus cereus) 		PF07537
(CamS) 		4 ASN A 124
THR A 195
SER A  73
SER A 153
 None
 1.47A 3hlwB-3n2qA:
undetectable		 3hlwB-3n2qA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne8 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Bartonella
henselae) 		PF01520
(Amidase_3) 		4 ASN A 291
THR A 270
SER A 279
ARG A 347
 None
 1.26A 3hlwB-3ne8A:
undetectable		 3hlwB-3ne8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		4 THR A 354
SER A 332
SER A 240
ARG A 330
 None
 1.39A 3hlwB-3ohnA:
undetectable		 3hlwB-3ohnA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ASN A 363
THR A 458
SER A 460
ARG A 459
 None
 1.30A 3hlwB-3qdeA:
undetectable		 3hlwB-3qdeA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		4 ASN A 248
THR A  35
SER A  31
ARG A  36
 None
GNP  A 500 (-4.2A)
None
None
 1.46A 3hlwB-3r7wA:
undetectable		 3hlwB-3r7wA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq1 AMINOTRANSFERASE
CLASS I AND II

(Veillonella
parvula) 		PF00155
(Aminotran_1_2) 		4 ASN A 187
THR A 109
SER A 258
ARG A 267
 None
None
None
OAA  A 422 (-3.7A)
 1.28A 3hlwB-3rq1A:
undetectable		 3hlwB-3rq1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ASN B 180
THR B 127
SER B 123
SER B 120
 None
 1.44A 3hlwB-3sqgB:
undetectable		 3hlwB-3sqgB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ASN A 513
THR A 304
SER A 280
ARG A 308
 None
 1.46A 3hlwB-3to3A:
undetectable		 3hlwB-3to3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vti HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ASN C 322
THR C 331
SER C 336
ARG C 337
 None
 1.22A 3hlwB-3vtiC:
undetectable		 3hlwB-3vtiC:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx8 AUTOPHAGY-RELATED
PROTEIN 3

(Arabidopsis
thaliana) 		PF03986
(Autophagy_N)
PF03987
(Autophagy_act_C)
PF10381
(Autophagy_C) 		4 THR B 200
SER B 198
SER B 254
ARG B 209
 None
 1.38A 3hlwB-3vx8B:
undetectable		 3hlwB-3vx8B:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x38 MITOCHONDRIAL
MORPHOGENESIS
PROTEIN SLD7

(Saccharomyces
cerevisiae) 		no annotation 4 ASN A 185
SER A 231
SER A 234
ARG A 229
 None
 1.32A 3hlwB-3x38A:
undetectable		 3hlwB-3x38A:
15.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		4 ASN A 132
SER A 237
SER A 274
ARG A 276
 None
 1.47A 3hlwB-3znyA:
47.8		 3hlwB-3znyA:
81.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		4 THR A 235
SER A 237
SER A 274
ARG A 276
 None
 1.06A 3hlwB-3znyA:
47.8		 3hlwB-3znyA:
81.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		4 ASN A  29
THR A  14
SER A  76
ARG A  74
 None
 1.47A 3hlwB-4b3kA:
undetectable		 3hlwB-4b3kA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A

(Homo sapiens) 		PF01201
(Ribosomal_S8e) 		4 ASN i 397
THR i 355
SER i 359
ARG i 362
 None
 0.96A 3hlwB-4d61i:
undetectable		 3hlwB-4d61i:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqu PUTATIVE GLUTATHIONE
TRANSFERASE

(Sphingobium
chlorophenolicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 ASN A 180
SER A 138
SER A  28
ARG A  31
 None
 1.47A 3hlwB-4fquA:
undetectable		 3hlwB-4fquA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frf INOSITOL
POLYPHOSPHATE
MULTIKINASE ALPHA

(Arabidopsis
thaliana) 		PF03770
(IPK) 		4 ASN A 261
THR A 125
SER A 135
ARG A 156
 SO4  A 302 ( 4.8A)
None
None
None
 1.36A 3hlwB-4frfA:
undetectable		 3hlwB-4frfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE

(Burkholderia
lata) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		4 ASN A 122
THR A  90
SER A  83
ARG A  87
 None
None
FMN  A 301 (-3.4A)
None
 1.27A 3hlwB-4hmwA:
undetectable		 3hlwB-4hmwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN

(Neisseria
meningitidis) 		PF00884
(Sulfatase) 		4 ASN A 250
THR A 241
SER A 451
SER A 275
 None
 1.49A 3hlwB-4kavA:
undetectable		 3hlwB-4kavA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6

(Saccharomyces
cerevisiae) 		PF01423
(LSM) 		4 THR D  23
SER D  35
SER D  51
ARG D  37
 None
 1.15A 3hlwB-4m75D:
undetectable		 3hlwB-4m75D:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 ASN A  93
THR A 186
SER A 170
ARG A 174
 None
None
173  A 401 (-2.6A)
None
 1.46A 3hlwB-4mniA:
undetectable		 3hlwB-4mniA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 THR A 639
SER A 636
SER A 489
ARG A 486
 None
 1.28A 3hlwB-4nreA:
undetectable		 3hlwB-4nreA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 ASN A  81
THR A 143
SER A 153
SER A  49
 None
 1.33A 3hlwB-4p5yA:
undetectable		 3hlwB-4p5yA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ASN A1147
THR A1134
SER A1132
SER A1103
 None
 1.46A 3hlwB-5a55A:
undetectable		 3hlwB-5a55A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		4 THR K 780
SER K 782
SER K 382
ARG K 536
 None
 1.32A 3hlwB-5anbK:
undetectable		 3hlwB-5anbK:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ASN A 113
THR A 464
SER A 454
SER A 505
 None
 1.44A 3hlwB-5bp1A:
undetectable		 3hlwB-5bp1A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 THR A 416
SER A 412
SER A 381
ARG A 413
 None
 1.27A 3hlwB-5e31A:
16.8		 3hlwB-5e31A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASN A 189
THR A 281
SER A 227
ARG A 283
 None
 1.46A 3hlwB-5fokA:
undetectable		 3hlwB-5fokA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 ASN A 603
THR A 712
SER A 764
SER A 573
 None
 1.09A 3hlwB-5im3A:
undetectable		 3hlwB-5im3A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		4 ASN B 368
THR B 363
SER B 351
ARG B 349
 None
 1.49A 3hlwB-5k7mB:
undetectable		 3hlwB-5k7mB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ASN A 424
THR A 288
SER A 277
SER A 227
 None
 1.26A 3hlwB-5t9gA:
undetectable		 3hlwB-5t9gA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 ASN A 445
THR A 555
SER A 596
SER A 415
 None
 1.10A 3hlwB-5tusA:
undetectable		 3hlwB-5tusA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v51 PR-1 PROTEIN

(Moniliophthora
perniciosa) 		PF00188
(CAP) 		4 ASN A 161
SER A 115
SER A 109
ARG A 114
 SEY  A 201 (-4.7A)
None
None
None
 1.16A 3hlwB-5v51A:
undetectable		 3hlwB-5v51A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi4 INTERLEUKIN-1
RECEPTOR-LIKE 1

(Mus musculus) 		PF13895
(Ig_2) 		4 ASN B 118
THR B 207
SER B 205
ARG B 129
 None
 1.20A 3hlwB-5vi4B:
undetectable		 3hlwB-5vi4B:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A
VESICLE-TRAFFICKING
PROTEIN SEC22B

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
PF13774
(Longin) 		4 THR B 424
SER C 107
SER C 111
ARG C 108
 None
 1.25A 3hlwB-5vniB:
undetectable		 3hlwB-5vniB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa) 		no annotation 4 THR X 221
SER X 107
SER X 209
ARG X 109
 None
 1.45A 3hlwB-5vtmX:
undetectable		 3hlwB-5vtmX:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yd5 SCFV 4B08

(Mus musculus) 		no annotation 4 THR A 217
SER A 208
SER A 221
ARG A 219
 None
None
SO4  A 303 (-2.8A)
SO4  A 303 (-3.8A)
 1.21A 3hlwB-5yd5A:
undetectable		 3hlwB-5yd5A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
epidermidis) 		no annotation 4 ASN A 153
SER A 173
SER A 194
ARG A 174
 None
 1.45A 3hlwB-5yjjA:
undetectable		 3hlwB-5yjjA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azi D-ALANYL-D-ALANINE
ENDOPEPTIDASE

(Enterobacter
cloacae) 		PF00768
(Peptidase_S11) 		4 ASN A 216
THR A 247
SER A 272
ARG A 275
 None
 1.40A 3hlwB-6aziA:
21.6		 3hlwB-6aziA:
27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 ASN A 104
THR A 235
SER A 237
SER A 274
ARG A 276
 3GK  A 301 ( 3.2A)
3GK  A 301 (-3.7A)
3GK  A 301 ( 2.7A)
SO4  A 303 ( 2.8A)
SO4  A 303 (-3.8A)
 0.55A 3hlwB-6bu3A:
49.6		 3hlwB-6bu3A:
97.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 ASN A 132
SER A 237
SER A 274
ARG A 276
 3GK  A 301 (-3.5A)
3GK  A 301 ( 2.7A)
SO4  A 303 ( 2.8A)
SO4  A 303 (-3.8A)
 1.18A 3hlwB-6bu3A:
49.6		 3hlwB-6bu3A:
97.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum) 		no annotation 4 THR A  35
SER A  43
SER A  82
ARG A  84
 None
 1.34A 3hlwB-6d47A:
undetectable		 3hlwB-6d47A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 ASN A 339
SER A 423
SER A  64
ARG A 437
 None
 1.39A 3hlwB-6frvA:
undetectable		 3hlwB-6frvA:
16.41