SIMILAR PATTERNS OF AMINO ACIDS FOR 3HLW_B_CE3B302_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00215
(OMPdecase) 		3 CYH A  33
PRO A 202
ASP A  91
 None
 0.94A 3hlwB-1dqwA:
0.0		 3hlwB-1dqwA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 CYH A 138
PRO A 345
ASP A 352
 None
 0.95A 3hlwB-1evjA:
0.0		 3hlwB-1evjA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fez PHOSPHONOACETALDEHYD
E HYDROLASE

(Bacillus cereus) 		PF13419
(HAD_2) 		3 CYH A 166
PRO A 153
ASP A 190
 None
 1.01A 3hlwB-1fezA:
undetectable		 3hlwB-1fezA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii) 		PF00995
(Sec1) 		3 CYH A 169
PRO A 164
ASP A 148
 None
 0.80A 3hlwB-1fvfA:
0.0		 3hlwB-1fvfA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 CYH A 190
PRO A 397
ASP A 404
 None
 0.96A 3hlwB-1h6dA:
0.0		 3hlwB-1h6dA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg3 TRIOSEPHOSPHATE
ISOMERASE

(Pyrococcus
woesei) 		PF00121
(TIM)
PF05690
(ThiG) 		3 CYH A 181
PRO A 160
ASP A 190
 None
 0.95A 3hlwB-1hg3A:
undetectable		 3hlwB-1hg3A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 CYH A 388
PRO A 307
ASP A 352
 None
 0.88A 3hlwB-1n21A:
0.0		 3hlwB-1n21A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv5 HYPOTHETICAL PROTEIN
YWQG

(Bacillus
subtilis) 		PF09234
(DUF1963) 		3 CYH A 134
PRO A 137
ASP A  91
 None
 0.98A 3hlwB-1pv5A:
undetectable		 3hlwB-1pv5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9m PROBABLE
PYRIDOXAMINE
5'-PHOSPHATE OXIDASE

(Pseudomonas
aeruginosa) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 CYH A 175
PRO A 172
ASP A  84
 None
SO4  A 352 (-3.8A)
None
 0.97A 3hlwB-1t9mA:
undetectable		 3hlwB-1t9mA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		3 CYH A  75
PRO A 102
ASP A 179
 None
None
PLP  A 513 (-2.8A)
 0.89A 3hlwB-1v72A:
undetectable		 3hlwB-1v72A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z06 RAS-RELATED PROTEIN
RAB-33B

(Mus musculus) 		PF00071
(Ras) 		3 CYH A  54
PRO A  59
ASP A  88
 None
None
MG  A 203 ( 3.8A)
 0.86A 3hlwB-1z06A:
undetectable		 3hlwB-1z06A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		3 CYH A 123
PRO A 136
ASP A  97
 None
 1.01A 3hlwB-1zbsA:
undetectable		 3hlwB-1zbsA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcr FLAVODOXIN

(Chondrus
crispus) 		PF00258
(Flavodoxin_1) 		3 CYH A 103
PRO A  99
ASP A 148
 FMN  A 174 (-4.3A)
None
None
 0.86A 3hlwB-2fcrA:
undetectable		 3hlwB-2fcrA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffw MIDLINE-1

(Homo sapiens) 		no annotation 3 CYH A 122
PRO A 126
ASP A 129
 ZN  A 200 (-2.3A)
None
None
 0.98A 3hlwB-2ffwA:
undetectable		 3hlwB-2ffwA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		3 CYH A 309
PRO A 321
ASP A 327
 None
 0.84A 3hlwB-2g29A:
undetectable		 3hlwB-2g29A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		3 CYH A 245
PRO A 103
ASP A 116
 None
 0.69A 3hlwB-2g4oA:
undetectable		 3hlwB-2g4oA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqe NUCLEAR PORE COMPLEX
PROTEIN NUP153

(Homo sapiens) 		PF00641
(zf-RanBP) 		3 CYH A  23
PRO A  18
ASP A   8
 ZN  A  32 (-2.4A)
None
None
 0.70A 3hlwB-2gqeA:
undetectable		 3hlwB-2gqeA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqe NUCLEAR PORE COMPLEX
PROTEIN NUP153

(Homo sapiens) 		PF00641
(zf-RanBP) 		3 CYH A  23
PRO A  31
ASP A   8
 ZN  A  32 (-2.4A)
None
None
 0.96A 3hlwB-2gqeA:
undetectable		 3hlwB-2gqeA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 CYH A 358
PRO A 394
ASP A 385
 None
 0.43A 3hlwB-2hneA:
undetectable		 3hlwB-2hneA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox1 3-DEHYDROQUINATE
DEHYDRATASE

(Archaeoglobus
fulgidus) 		PF01487
(DHquinase_I) 		3 CYH A 172
PRO A 177
ASP A 187
 None
 0.87A 3hlwB-2ox1A:
undetectable		 3hlwB-2ox1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 CYH A  51
PRO A  63
ASP A  12
 None
 0.95A 3hlwB-2qddA:
undetectable		 3hlwB-2qddA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7y CHAPERONE PROTEIN
DNAK

(Geobacillus
kaustophilus) 		PF00012
(HSP70) 		3 CYH A  15
PRO A  37
ASP A 337
 None
None
ADP  A1505 ( 4.6A)
 0.93A 3hlwB-2v7yA:
undetectable		 3hlwB-2v7yA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 CYH A 433
PRO A 437
ASP A 354
 None
 0.95A 3hlwB-2vr2A:
undetectable		 3hlwB-2vr2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		3 CYH A 161
PRO A 222
ASP A 209
 None
 0.84A 3hlwB-2vreA:
undetectable		 3hlwB-2vreA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9z G1/S-SPECIFIC
CYCLIN-D1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		3 CYH A 106
PRO A  79
ASP A  86
 None
 0.88A 3hlwB-2w9zA:
undetectable		 3hlwB-2w9zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		3 CYH A 428
PRO A 478
ASP A 482
 None
 0.92A 3hlwB-2whxA:
undetectable		 3hlwB-2whxA:
17.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		3 CYH A  69
PRO A 167
ASP A 240
 None
 0.61A 3hlwB-2wyxA:
46.0		 3hlwB-2wyxA:
83.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzo TRANSFORMING GROWTH
FACTOR BETA
REGULATOR 1

(Homo sapiens) 		PF05964
(FYRN)
PF05965
(FYRC) 		3 CYH A 232
PRO A 228
ASP A 254
 None
 1.00A 3hlwB-2wzoA:
undetectable		 3hlwB-2wzoA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		3 CYH A  13
PRO A  32
ASP A  26
 None
 0.89A 3hlwB-2xu2A:
undetectable		 3hlwB-2xu2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		3 CYH A 120
PRO A 168
ASP A 171
 None
 0.80A 3hlwB-2z6vA:
undetectable		 3hlwB-2z6vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 CYH A 270
PRO A 106
ASP A 117
 None
 0.92A 3hlwB-3aatA:
undetectable		 3hlwB-3aatA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01336
(tRNA_anti-codon)
PF08489
(DUF1743) 		3 CYH A 204
PRO A 398
ASP A 184
 None
 0.94A 3hlwB-3au7A:
undetectable		 3hlwB-3au7A:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3byd BETA-LACTAMASE OXY-1

(Klebsiella
oxytoca) 		PF13354
(Beta-lactamase2) 		3 CYH A  72
PRO A 170
ASP A 242
 None
 0.55A 3hlwB-3bydA:
47.1		 3hlwB-3bydA:
74.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		3 CYH A 261
PRO A 274
ASP A 238
 None
 0.99A 3hlwB-3dr2A:
undetectable		 3hlwB-3dr2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 CYH A 269
PRO A 264
ASP A 444
 None
 0.97A 3hlwB-3dzuA:
undetectable		 3hlwB-3dzuA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edv SPECTRIN BETA CHAIN,
BRAIN 1

(Homo sapiens) 		PF00435
(Spectrin) 		3 CYH A1900
PRO A1829
ASP A1852
 None
 0.88A 3hlwB-3edvA:
undetectable		 3hlwB-3edvA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE

(Mus musculus) 		no annotation 3 CYH A 128
PRO A 124
ASP A 111
 None
 0.98A 3hlwB-3ewiA:
undetectable		 3hlwB-3ewiA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g33 CCND3 PROTEIN

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		3 CYH B 106
PRO B  79
ASP B  86
 None
 0.90A 3hlwB-3g33B:
undetectable		 3hlwB-3g33B:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		3 CYH A 306
PRO A 230
ASP A 376
 BGC  A   4 (-4.8A)
None
None
 0.93A 3hlwB-3gd9A:
undetectable		 3hlwB-3gd9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		3 CYH A 326
PRO A 320
ASP A 311
 None
 0.98A 3hlwB-3gd9A:
undetectable		 3hlwB-3gd9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		3 CYH A 169
PRO A 199
ASP A 215
 None
C2E  A 501 (-4.3A)
C2E  A 501 (-3.2A)
 0.95A 3hlwB-3gg0A:
undetectable		 3hlwB-3gg0A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3l PUTATIVE SUGAR
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		3 CYH A 234
PRO A 231
ASP A 169
 None
 0.93A 3hlwB-3h3lA:
undetectable		 3hlwB-3h3lA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		3 CYH A 100
PRO A 160
ASP A 110
 None
NAD  A 505 (-4.4A)
None
 0.97A 3hlwB-3iwkA:
undetectable		 3hlwB-3iwkA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES1

(Plasmodium
falciparum) 		PF01015
(Ribosomal_S3Ae) 		3 CYH B  96
PRO B  35
ASP B  89
 None
 0.89A 3hlwB-3j7aB:
undetectable		 3hlwB-3j7aB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj8 TYROSINE-PROTEIN
PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc) 		3 CYH A 290
PRO A 256
ASP A 259
 None
 0.98A 3hlwB-3lj8A:
undetectable		 3hlwB-3lj8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lud PROTEIN ARGONAUTE-2

(Homo sapiens) 		PF02171
(Piwi)
PF16487
(ArgoMid) 		3 CYH A 564
PRO A 557
ASP A 480
 None
 0.90A 3hlwB-3ludA:
undetectable		 3hlwB-3ludA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfz ASPARTOACYLASE-2

(Mus musculus) 		PF04952
(AstE_AspA) 		3 CYH A  26
PRO A 182
ASP A 189
 None
 0.86A 3hlwB-3nfzA:
undetectable		 3hlwB-3nfzA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		3 CYH A 153
PRO A 148
ASP A 164
 None
 0.89A 3hlwB-3p3lA:
undetectable		 3hlwB-3p3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyn TUMOR PROTEIN 63

(Homo sapiens) 		PF00870
(P53) 		3 CYH A 306
PRO A 281
ASP A 316
 None
 0.95A 3hlwB-3qynA:
undetectable		 3hlwB-3qynA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00215
(OMPdecase) 		3 CYH A   4
PRO A 174
ASP A  58
 None
 0.95A 3hlwB-3ru6A:
undetectable		 3hlwB-3ru6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6b METHIONINE
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24) 		3 CYH A 166
PRO A 163
ASP A 137
 None
 0.95A 3hlwB-3s6bA:
undetectable		 3hlwB-3s6bA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sma FRBF

(Streptomyces
rubellomurinus) 		PF02522
(Antibiotic_NAT) 		3 CYH A 241
PRO A 246
ASP A 268
 None
 0.92A 3hlwB-3smaA:
undetectable		 3hlwB-3smaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 CYH B 331
PRO B 341
ASP B 344
 None
 0.75A 3hlwB-3sqgB:
undetectable		 3hlwB-3sqgB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trd ALPHA/BETA HYDROLASE

(Coxiella
burnetii) 		PF00561
(Abhydrolase_1) 		3 CYH A  34
PRO A  38
ASP A  87
 None
 0.89A 3hlwB-3trdA:
undetectable		 3hlwB-3trdA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tre ELONGATION FACTOR P

(Coxiella
burnetii) 		PF01132
(EFP)
PF08207
(EFP_N)
PF09285
(Elong-fact-P_C) 		3 CYH A  22
PRO A  63
ASP A  18
 None
 0.88A 3hlwB-3treA:
undetectable		 3hlwB-3treA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04410
(Gar1) 		3 CYH C  53
PRO C  46
ASP C 107
 None
 0.90A 3hlwB-3uaiC:
undetectable		 3hlwB-3uaiC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE

(Bacillus
subtilis) 		PF01884
(PcrB) 		3 CYH A 119
PRO A 123
ASP A 141
 None
 0.90A 3hlwB-3vzxA:
undetectable		 3hlwB-3vzxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 CYH E 787
PRO E 797
ASP E 801
 None
 0.91A 3hlwB-4a0lE:
undetectable		 3hlwB-4a0lE:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 CYH A 432
PRO A 436
ASP A 353
 None
 0.97A 3hlwB-4b90A:
undetectable		 3hlwB-4b90A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 CYH A 432
PRO A 436
ASP A 353
 None
 0.94A 3hlwB-4b92A:
undetectable		 3hlwB-4b92A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 PROTEIN CAF40

(Saccharomyces
cerevisiae) 		PF04078
(Rcd1) 		3 CYH B 185
PRO B 190
ASP B 137
 None
 0.78A 3hlwB-4cv5B:
undetectable		 3hlwB-4cv5B:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		3 CYH A 309
PRO A 109
ASP A 146
 None
 0.97A 3hlwB-4e51A:
undetectable		 3hlwB-4e51A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 CYH A 356
PRO A 392
ASP A 383
 None
 0.40A 3hlwB-4ip4A:
undetectable		 3hlwB-4ip4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ize INTERLEUKIN-36 GAMMA

(Homo sapiens) 		PF00340
(IL1) 		3 CYH A  85
PRO A 116
ASP A 106
 None
 1.02A 3hlwB-4izeA:
undetectable		 3hlwB-4izeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kma GM14141P

(Drosophila
melanogaster) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		3 CYH A 143
PRO A 312
ASP A 154
 None
 0.69A 3hlwB-4kmaA:
undetectable		 3hlwB-4kmaA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		3 CYH A 198
PRO A 310
ASP A 201
 None
 0.96A 3hlwB-4kpnA:
undetectable		 3hlwB-4kpnA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3z RAB5 GDP/GTP
EXCHANGE FACTOR

(Homo sapiens) 		PF02204
(VPS9) 		3 CYH A 290
PRO A 284
ASP A 279
 None
 0.91A 3hlwB-4n3zA:
undetectable		 3hlwB-4n3zA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 CYH A 684
PRO A 742
ASP A 754
 None
 0.92A 3hlwB-4okdA:
undetectable		 3hlwB-4okdA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 CYH A 574
PRO A 581
ASP A 592
 None
 0.86A 3hlwB-4oqjA:
undetectable		 3hlwB-4oqjA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdj CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		3 CYH A 287
PRO A 322
ASP A 310
 None
 0.99A 3hlwB-4rdjA:
undetectable		 3hlwB-4rdjA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		3 CYH A 198
PRO A 150
ASP A 202
 None
 0.97A 3hlwB-4zoyA:
undetectable		 3hlwB-4zoyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		3 CYH B 140
PRO B 122
ASP B 127
 None
 1.00A 3hlwB-5a7vB:
undetectable		 3hlwB-5a7vB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e05 NUCLEOCAPSID PROTEIN

(Sin Nombre
orthohantavirus) 		PF00846
(Hanta_nucleocap) 		3 CYH A 203
PRO A 316
ASP A 312
 None
 0.98A 3hlwB-5e05A:
undetectable		 3hlwB-5e05A:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		3 CYH A  46
PRO A 144
ASP A 216
 None
 0.35A 3hlwB-5e2eA:
44.4		 3hlwB-5e2eA:
58.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		3 CYH A  41
PRO A  63
ASP A 391
 None
 0.94A 3hlwB-5e84A:
undetectable		 3hlwB-5e84A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyg INOSITOL
MONOPHOSPHATASE

(Staphylococcus
aureus) 		PF00459
(Inositol_P) 		3 CYH A 104
PRO A  89
ASP A 209
 None
None
CA  A 301 ( 3.0A)
 1.01A 3hlwB-5eygA:
undetectable		 3hlwB-5eygA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7o METHYLTHIOADENOSINE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		3 CYH A 172
PRO A  98
ASP A  95
 None
 1.00A 3hlwB-5f7oA:
undetectable		 3hlwB-5f7oA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA

(Homo sapiens) 		no annotation 3 CYH B 840
PRO B 845
ASP B 827
 None
 0.96A 3hlwB-5h1uB:
undetectable		 3hlwB-5h1uB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdw F-BOX ONLY PROTEIN 3

(Homo sapiens) 		PF04379
(DUF525) 		3 CYH A 324
PRO A 320
ASP A 283
 None
 1.02A 3hlwB-5hdwA:
undetectable		 3hlwB-5hdwA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 CYH A 447
PRO A 792
ASP A 422
 None
 0.92A 3hlwB-5hy7A:
undetectable		 3hlwB-5hy7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 CYH A 478
PRO A 475
ASP A 517
 None
 0.81A 3hlwB-5i2tA:
undetectable		 3hlwB-5i2tA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE

(Bradyrhizobium
sp.) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 CYH A 156
PRO A  34
ASP A  64
 None
 0.99A 3hlwB-5k8oA:
undetectable		 3hlwB-5k8oA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 CYH A 216
PRO A  16
ASP A  19
 None
 0.93A 3hlwB-5kyvA:
undetectable		 3hlwB-5kyvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		3 CYH A 274
PRO A  93
ASP A 130
 None
 0.87A 3hlwB-5lv9A:
undetectable		 3hlwB-5lv9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 CYH A 350
PRO A 353
ASP A 398
 None
 0.97A 3hlwB-5nv3A:
undetectable		 3hlwB-5nv3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 3 CYH A 471
PRO A 572
ASP A 123
 None
 0.87A 3hlwB-5ohsA:
undetectable		 3hlwB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1q N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
DOMAIN-CONTAINING
PROTEIN
SAOUHSC_02979

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase)
PF05257
(CHAP) 		3 CYH A 513
PRO A 509
ASP A 534
 None
 0.79A 3hlwB-5t1qA:
undetectable		 3hlwB-5t1qA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		3 CYH A 568
PRO A 565
ASP A 309
 None
 1.00A 3hlwB-5uj6A:
undetectable		 3hlwB-5uj6A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 CYH A 169
PRO A 164
ASP A 459
 None
FAD  A 503 (-3.3A)
None
 1.01A 3hlwB-5vj7A:
undetectable		 3hlwB-5vj7A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 CYH A 280
PRO A 270
ASP A 179
 None
 0.47A 3hlwB-5vm1A:
undetectable		 3hlwB-5vm1A:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vpq BETA-LACTAMASE

(Paraburkholderia
phymatum) 		PF13354
(Beta-lactamase2) 		3 CYH A  57
PRO A 156
ASP A 230
 None
None
EDO  A 304 (-3.7A)
 0.57A 3hlwB-5vpqA:
41.6		 3hlwB-5vpqA:
48.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14

(Saccharomyces
cerevisiae) 		PF00782
(DSPc)
PF14671
(DSPn) 		3 CYH A  96
PRO A 126
ASP A 143
 None
 1.01A 3hlwB-5xw5A:
undetectable		 3hlwB-5xw5A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 CYH C2248
PRO C2252
ASP C2208
 None
 0.87A 3hlwB-5y3rC:
undetectable		 3hlwB-5y3rC:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykn PROBABLE
LYSINE-SPECIFIC
DEMETHYLASE JMJ14

(Arabidopsis
thaliana) 		no annotation 3 CYH A 550
PRO A 537
ASP A 556
 ZN  A 802 (-3.3A)
None
None
 0.95A 3hlwB-5yknA:
undetectable		 3hlwB-5yknA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 3 CYH A  66
PRO A 137
ASP A 140
 FES  A 601 (-2.3A)
None
MG  A 606 ( 3.0A)
 1.01A 3hlwB-5ze4A:
undetectable		 3hlwB-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 3 CYH A 681
PRO A 684
ASP A 598
 None
 0.86A 3hlwB-6aunA:
undetectable		 3hlwB-6aunA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 3 CYH G 400
PRO G 394
ASP G 390
 None
 0.89A 3hlwB-6criG:
undetectable		 3hlwB-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1
SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 3 CYH C 677
PRO C 718
ASP A 147
 None
 0.73A 3hlwB-6en4C:
undetectable		 3hlwB-6en4C:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 3 CYH A  41
PRO A  63
ASP A 391
 None
None
ADP  A 603 (-3.6A)
 0.92A 3hlwB-6eoeA:
undetectable		 3hlwB-6eoeA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		no annotation 3 CYH A 319
PRO A 259
ASP A 325
 None
 0.86A 3hlwB-6fv4A:
undetectable		 3hlwB-6fv4A:
15.21