SIMILAR PATTERNS OF AMINO ACIDS FOR 3HGG_A_CHDA211_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gux RETINOBLASTOMA
PROTEIN
RETINOBLASTOMA
PROTEIN

(Homo sapiens;
Homo sapiens) 		PF01858
(RB_A)
PF01857
(RB_B)
PF08934
(Rb_C) 		4 PHE A 526
PHE B 650
PHE A 570
SER A 567
 None
 1.33A 3hggA-1guxA:
undetectable		 3hggA-1guxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		4 CYH A  38
PHE A  23
SER A 280
TYR A  18
 None
 1.49A 3hggA-1gvfA:
undetectable		 3hggA-1gvfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		4 PHE A 297
PHE A 184
SER A 181
TYR A 180
 None
 1.49A 3hggA-1j5xA:
0.0		 3hggA-1j5xA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Methanothermobacter
thermautotrophicus) 		PF00483
(NTP_transferase) 		4 PHE A  96
PHE A  75
SER A  76
TYR A  77
 None
 1.46A 3hggA-1lvwA:
undetectable		 3hggA-1lvwA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3p LECTIN PAL

(Pterocarpus
angolensis) 		PF00139
(Lectin_legB) 		4 PHE A  73
PHE A 215
PHE A  69
SER A  71
 None
 1.47A 3hggA-1n3pA:
undetectable		 3hggA-1n3pA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2z ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT

(Homo sapiens) 		PF08785
(Ku_PK_bind) 		4 CYH A  49
PHE A  85
PHE A  34
TYR A  42
 None
 1.34A 3hggA-1q2zA:
1.9		 3hggA-1q2zA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukf AVIRULENCE PROTEIN
AVRPPH3

(Pseudomonas
savastanoi) 		PF03543
(Peptidase_C58) 		4 CYH A 260
PHE A 264
PHE A 155
SER A 203
 None
 1.16A 3hggA-1ukfA:
1.1		 3hggA-1ukfA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		4 PHE A 241
PHE A 227
SER A 225
LYS A 110
 None
 1.23A 3hggA-1x3wA:
0.1		 3hggA-1x3wA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypz T CELL RECEPTOR
DELTA
T-CELL RECEPTOR
GAMMA CHAIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 PHE E  35
PHE F 109
PHE F 105
TYR E  48
 None
 1.22A 3hggA-1ypzE:
undetectable		 3hggA-1ypzE:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd1 SULFOTRANSFERASE 4A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 PHE A 158
PHE A 257
PHE A 165
TYR A 142
 None
 1.25A 3hggA-1zd1A:
undetectable		 3hggA-1zd1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		4 CYH A  68
PHE A 421
PHE A 416
TYR A 104
 None
 1.45A 3hggA-1zy9A:
undetectable		 3hggA-1zy9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9m FLUORESCEIN-SCFV
HEAVY CHAIN
FLUORESCEIN-SCFV
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 PHE L 137
PHE L 139
SER L  42
TYR H 135
 None
 1.36A 3hggA-2a9mL:
undetectable		 3hggA-2a9mL:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx6 XRP2 PROTEIN

(Homo sapiens) 		PF07986
(TBCC) 		4 CYH A 130
PHE A 167
PHE A 159
SER A 165
 None
 1.40A 3hggA-2bx6A:
1.0		 3hggA-2bx6A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 PHE A 172
PHE A 115
PHE A 168
TYR A 411
 None
 0.95A 3hggA-2d1gA:
undetectable		 3hggA-2d1gA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfk COLLYBISTIN II

(Rattus
norvegicus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 CYH A 171
PHE A  96
PHE A 167
TYR A 164
 None
 1.31A 3hggA-2dfkA:
1.2		 3hggA-2dfkA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Thermotoga
maritima) 		PF04204
(HTS) 		4 CYH A 291
PHE A 179
PHE A 283
SER A 176
 None
 1.01A 3hggA-2h2wA:
undetectable		 3hggA-2h2wA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		4 CYH A 405
PHE A 330
PHE A 401
TYR A 398
 None
 1.31A 3hggA-2pz1A:
2.2		 3hggA-2pz1A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		4 PHE A 108
PHE A 101
SER A 113
TYR A  66
 None
 1.24A 3hggA-2q01A:
undetectable		 3hggA-2q01A:
16.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qco CMER

(Campylobacter
jejuni) 		PF00440
(TetR_N) 		6 CYH A  69
PHE A  99
PHE A 103
PHE A 137
SER A 138
TYR A 139
 None
GOL  A 301 (-4.7A)
GOL  A 301 (-4.7A)
None
GOL  A 301 (-2.9A)
GOL  A 301 (-4.6A)
 0.39A 3hggA-2qcoA:
30.3		 3hggA-2qcoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qco CMER

(Campylobacter
jejuni) 		PF00440
(TetR_N) 		4 CYH A  69
PHE A 103
PHE A 137
LYS A 170
 None
GOL  A 301 (-4.7A)
None
GOL  A 301 ( 4.7A)
 0.82A 3hggA-2qcoA:
30.3		 3hggA-2qcoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3h K5 LYASE

(Escherichia
virus K1-5) 		no annotation 4 PHE A 318
PHE A 341
PHE A 349
TYR A 326
 None
 1.01A 3hggA-2x3hA:
undetectable		 3hggA-2x3hA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 PHE A 119
PHE A 114
PHE A  90
SER A  89
 None
 1.20A 3hggA-3e0lA:
undetectable		 3hggA-3e0lA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		4 CYH A 326
PHE A  39
PHE A 388
TYR A 374
 None
 1.47A 3hggA-3eleA:
undetectable		 3hggA-3eleA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PHE A 407
PHE A 478
SER A 476
TYR A 477
 None
 1.41A 3hggA-3fhhA:
undetectable		 3hggA-3fhhA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		4 PHE C 136
PHE C 135
PHE C 282
SER C 285
 None
 1.31A 3hggA-3gi8C:
0.8		 3hggA-3gi8C:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 PHE A 403
PHE A 267
PHE A 374
SER A 375
 None
 1.38A 3hggA-3hhsA:
undetectable		 3hggA-3hhsA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1l HEMAGGLUTININ-ESTERA
SE PROTEIN

(Porcine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 CYH A  41
PHE A  43
SER A  70
TYR A  94
 None
 1.38A 3hggA-3i1lA:
undetectable		 3hggA-3i1lA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		4 PHE A 417
PHE A 209
PHE A 289
SER A 292
 None
 1.35A 3hggA-3ifsA:
undetectable		 3hggA-3ifsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 PHE W 381
PHE W 350
PHE W 365
SER W 363
 None
 1.34A 3hggA-3iylW:
undetectable		 3hggA-3iylW:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 CYH A 296
PHE A 283
PHE A 278
PHE A 266
 None
 1.37A 3hggA-3j2iA:
undetectable		 3hggA-3j2iA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		4 CYH A1384
PHE A1411
PHE A1367
PHE A1380
 None
 1.28A 3hggA-3jroA:
undetectable		 3hggA-3jroA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 CYH A 723
SER A 592
TYR A 589
LYS A 581
 None
None
None
ANP  A 877 (-2.7A)
 1.47A 3hggA-3lltA:
undetectable		 3hggA-3lltA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvx PROTEIN A39

(Vaccinia virus) 		PF01403
(Sema) 		4 PHE A 245
PHE A 346
SER A 253
TYR A 225
 None
 1.41A 3hggA-3nvxA:
undetectable		 3hggA-3nvxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PHE A 658
PHE A 258
PHE A 164
TYR A 644
 None
 1.41A 3hggA-3o5aA:
undetectable		 3hggA-3o5aA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP

(Staphylococcus
aureus) 		no annotation 4 PHE A  62
PHE A  38
SER A 102
TYR A 103
 None
 1.38A 3hggA-4ae5A:
undetectable		 3hggA-4ae5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA

(Dictyostelium
discoideum) 		PF01267
(F-actin_cap_A) 		4 CYH A  21
PHE A 195
SER A 164
TYR A 163
 None
 1.47A 3hggA-4akrA:
undetectable		 3hggA-4akrA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 PHE A 132
PHE A 110
SER A 129
TYR A 120
 None
 1.36A 3hggA-4cj0A:
undetectable		 3hggA-4cj0A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e13 DIKETOREDUCTASE

(Acinetobacter
baylyi) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PHE A 258
PHE A 236
SER A 248
TYR A 245
 None
None
1PE  A 306 (-3.1A)
None
 1.50A 3hggA-4e13A:
1.7		 3hggA-4e13A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 PHE A 526
PHE A 650
PHE A 570
SER A 567
 None
 1.27A 3hggA-4ellA:
undetectable		 3hggA-4ellA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN

(Enterococcus
faecalis) 		PF00497
(SBP_bac_3) 		4 PHE A 107
PHE A  36
SER A 109
TYR A 181
 None
 1.46A 3hggA-4g4pA:
undetectable		 3hggA-4g4pA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE C 203
PHE C 226
SER C 194
TYR C 198
 None
 1.43A 3hggA-4gypC:
undetectable		 3hggA-4gypC:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9c BACTERIAL
TRANSFERASE
HEXAPEPTIDE (THREE
REPEATS) FAMILY
PROTEIN

(Acinetobacter
baumannii) 		PF00132
(Hexapep) 		4 PHE A 148
PHE A 128
SER A 134
TYR A 135
 None
 1.41A 3hggA-4m9cA:
undetectable		 3hggA-4m9cA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis) 		no annotation 4 CYH C  72
PHE C  41
PHE C  17
TYR C  31
 None
 1.35A 3hggA-4nv1C:
undetectable		 3hggA-4nv1C:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 CYH D 219
PHE D 212
PHE D 304
TYR D 300
 None
 1.37A 3hggA-4xgcD:
undetectable		 3hggA-4xgcD:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25

([Candida]
glabrata) 		PF00069
(Pkinase) 		4 CYH A 207
PHE A 273
PHE A 102
TYR A 282
 None
 1.45A 3hggA-4xhgA:
undetectable		 3hggA-4xhgA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhl CASEIN KINASE I
HOMOLOG HRR25

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 CYH A 207
PHE A 273
PHE A 102
TYR A 282
 None
 1.30A 3hggA-4xhlA:
undetectable		 3hggA-4xhlA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		4 CYH B 384
PHE B 411
PHE B 367
PHE B 380
 None
 1.21A 3hggA-4xmmB:
undetectable		 3hggA-4xmmB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		4 PHE A 298
PHE A 204
SER A 206
TYR A 205
 None
 1.43A 3hggA-4xzbA:
undetectable		 3hggA-4xzbA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		4 CYH A 281
PHE A 436
PHE A 434
TYR A 385
 None
 1.19A 3hggA-5e9jA:
undetectable		 3hggA-5e9jA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		4 CYH A 281
PHE A 472
PHE A 470
TYR A 385
 None
 1.16A 3hggA-5e9wA:
undetectable		 3hggA-5e9wA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyy CENTROLOBIUM
TOMENTOSUM LECTIN

(Centrolobium
tomentosum) 		PF00139
(Lectin_legB) 		4 PHE A  74
PHE A 216
PHE A  70
SER A  72
 None
 1.44A 3hggA-5eyyA:
undetectable		 3hggA-5eyyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE

(Caldicellulosiruptor
sp. F32) 		PF00150
(Cellulase) 		4 CYH A 357
PHE A 307
PHE A 327
TYR A 274
 None
None
None
CTT  A 401 ( 3.6A)
 1.40A 3hggA-5h4rA:
0.8		 3hggA-5h4rA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		4 PHE A 180
PHE A 196
PHE A  91
LYS A 183
 None
 1.19A 3hggA-5h7dA:
undetectable		 3hggA-5h7dA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdm MAJOR TEGUMENT
PROTEIN

(Human
gammaherpesvirus
4) 		PF12818
(Tegument_dsDNA) 		4 PHE D 467
PHE D 570
SER D 544
TYR D 393
 None
 1.46A 3hggA-5kdmD:
2.5		 3hggA-5kdmD:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpi GRAINYHEAD-LIKE
PROTEIN 1 HOMOLOG

(Homo sapiens) 		no annotation 4 CYH A 335
PHE A 308
PHE A 382
PHE A 473
 None
 1.17A 3hggA-5mpiA:
undetectable		 3hggA-5mpiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		4 CYH A 117
PHE A 156
PHE A 146
PHE A 107
 None
 1.42A 3hggA-5mulA:
undetectable		 3hggA-5mulA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PHE B 925
PHE B1048
SER B 990
TYR B 937
 None
 1.08A 3hggA-5vniB:
undetectable		 3hggA-5vniB:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE

(Methanopyrus
kandleri) 		no annotation 4 CYH A  59
PHE A  89
PHE A  82
TYR A  96
 None
 1.38A 3hggA-5x89A:
undetectable		 3hggA-5x89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		no annotation 4 PHE A 386
PHE A  89
PHE A 240
TYR A 109
 None
 1.45A 3hggA-6c8aA:
undetectable		 3hggA-6c8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 CYH A1283
PHE A1276
PHE A1280
SER A1290
 None
 1.50A 3hggA-6emkA:
undetectable		 3hggA-6emkA:
undetectable