SIMILAR PATTERNS OF AMINO ACIDS FOR 3HEC_A_STIA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  54
GLU A  74
LEU A  78
ILE A  87
LEU A 170
 ANP  A 400 (-3.3A)
None
None
ANP  A 400 (-4.9A)
ANP  A 400 (-4.0A)
 0.77A 3hecA-1cm8A:
36.7		 3hecA-1cm8A:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  33
ALA A  54
LYS A  56
GLU A  74
LEU A  78
ILE A  87
 ANP  A 400 ( 4.9A)
ANP  A 400 (-3.3A)
ANP  A 400 (-2.9A)
None
None
ANP  A 400 (-4.9A)
 0.68A 3hecA-1cm8A:
36.7		 3hecA-1cm8A:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  33
ALA A  54
LYS A  56
LEU A  77
LEU A  78
 ANP  A 400 ( 4.9A)
ANP  A 400 (-3.3A)
ANP  A 400 (-2.9A)
None
None
 0.73A 3hecA-1cm8A:
36.7		 3hecA-1cm8A:
61.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m32 2-AMINOETHYLPHOSPHON
ATE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		5 VAL A  59
ALA A 206
ILE A 165
LEU A 211
ASP A 167
 None
None
None
None
PLP  A4401 (-2.9A)
 0.95A 3hecA-1m32A:
undetectable		 3hecA-1m32A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 621
LEU A 644
THR A 670
ASP A 810
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.60A 3hecA-1t46A:
20.3		 3hecA-1t46A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 621
LYS A 623
GLU A 640
LEU A 644
THR A 670
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-3.6A)
 0.67A 3hecA-1t46A:
20.3		 3hecA-1t46A:
26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  77
 None
 0.47A 3hecA-1zwsA:
22.7		 3hecA-1zwsA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A  95
 None
 0.52A 3hecA-1zwsA:
22.7		 3hecA-1zwsA:
30.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  77
 GOL  A3001 (-3.5A)
None
None
None
GOL  A3001 (-4.8A)
 0.52A 3hecA-2a2aA:
22.3		 3hecA-2a2aA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A  95
 GOL  A3001 (-3.5A)
None
None
None
None
 0.51A 3hecA-2a2aA:
22.3		 3hecA-2a2aA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  60
LEU A  91
ASP A 156
 None
 0.71A 3hecA-2bdwA:
21.9		 3hecA-2bdwA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 184
LYS A 186
GLU A 201
LEU A 205
LEU A 238
 None
 0.46A 3hecA-2eu9A:
25.4		 3hecA-2eu9A:
27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A  40
LEU A  63
ILE A  72
LEU A  95
ASP A 155
 ADP  A 500 ( 3.7A)
None
None
ADP  A 500 ( 4.9A)
ADP  A 500 ( 2.9A)
 0.81A 3hecA-2f9gA:
23.7		 3hecA-2f9gA:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
GLU A  59
LEU A  63
ILE A  72
LEU A  95
 ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
ADP  A 500 ( 4.9A)
 0.52A 3hecA-2f9gA:
23.7		 3hecA-2f9gA:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
LYS A 273
GLU A 288
LEU A 291
THR A 316
ASP A 382
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.61A 3hecA-2og8A:
18.9		 3hecA-2og8A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 ALA A  46
LEU A  77
ILE A  87
LEU A 105
ASP A 167
 ATP  A 381 (-3.5A)
None
None
None
MN  A 382 (-2.0A)
 1.04A 3hecA-2phkA:
22.2		 3hecA-2phkA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 627
ALA A 651
ILE A 683
THR A 699
ASP A 764
 None
PTR  A 701 ( 4.7A)
None
None
None
 0.76A 3hecA-2qobA:
21.1		 3hecA-2qobA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 627
ALA A 651
LYS A 653
GLU A 670
ILE A 683
 None
PTR  A 701 ( 4.7A)
None
None
None
 0.87A 3hecA-2qobA:
21.1		 3hecA-2qobA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 627
ALA A 651
LYS A 653
ILE A 683
ASP A 764
 None
PTR  A 701 ( 4.7A)
None
None
None
 0.78A 3hecA-2qobA:
21.1		 3hecA-2qobA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A 449
LYS A 451
GLU A 463
LEU A 467
ILE A 477
THR A 493
LEU A 495
 None
 0.62A 3hecA-2qr7A:
19.2		 3hecA-2qr7A:
29.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  77
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
ADP  A1303 ( 4.2A)
 0.56A 3hecA-2w4kA:
22.4		 3hecA-2w4kA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A  95
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
 0.56A 3hecA-2w4kA:
22.4		 3hecA-2w4kA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 445
LEU A 463
ILE A 473
LEU A 491
ASP A 557
 None
 0.95A 3hecA-2wntA:
19.0		 3hecA-2wntA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 445
LYS A 447
GLU A 459
LEU A 463
ILE A 473
THR A 489
LEU A 491
 None
 0.80A 3hecA-2wntA:
19.0		 3hecA-2wntA:
30.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  77
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 3.8A)
 0.64A 3hecA-2yabA:
22.3		 3hecA-2yabA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A  95
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
 0.56A 3hecA-2yabA:
22.3		 3hecA-2yabA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A  95
 4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
GOL  A 503 (-2.8A)
None
4RB  A 401 (-4.4A)
 0.56A 3hecA-3bqrA:
21.0		 3hecA-3bqrA:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
LEU A  68
ILE A  77
LEU A  95
 4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
None
4RB  A 401 ( 4.3A)
4RB  A 401 (-4.4A)
 0.66A 3hecA-3bqrA:
21.0		 3hecA-3bqrA:
28.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLU A  72
LEU A  75
LEU A  76
ILE A  85
ASP A 168
 None
 0.95A 3hecA-3coiA:
37.7		 3hecA-3coiA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  31
ALA A  52
GLU A  72
LEU A  75
LEU A  76
ILE A  85
LEU A 167
 None
 0.68A 3hecA-3coiA:
37.7		 3hecA-3coiA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  53
GLU A  73
LEU A  77
ILE A  86
LEU A 110
LEU A 168
 35F  A   1 (-3.6A)
None
None
None
35F  A   1 (-4.5A)
35F  A   1 (-4.5A)
 0.74A 3hecA-3e7oA:
34.1		 3hecA-3e7oA:
50.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  53
LYS A  55
GLU A  73
LEU A  77
ILE A  86
LEU A 110
 35F  A   1 (-3.6A)
35F  A   1 ( 4.6A)
None
None
None
35F  A   1 (-4.5A)
 0.53A 3hecA-3e7oA:
34.1		 3hecA-3e7oA:
50.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  53
LYS A  55
LEU A  77
ILE A  86
LEU A 110
ASP A 169
 35F  A   1 (-3.6A)
35F  A   1 ( 4.6A)
None
None
35F  A   1 (-4.5A)
None
 0.68A 3hecA-3e7oA:
34.1		 3hecA-3e7oA:
50.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eea GAF DOMAIN/HD DOMAIN
PROTEIN

(Geobacter
sulfurreducens) 		PF13492
(GAF_3) 		5 VAL A  61
LEU A  79
ILE A  72
LEU A 103
ASP A  45
 None
None
PG6  A 163 (-4.4A)
PG6  A 163 (-4.7A)
None
 1.06A 3hecA-3eeaA:
undetectable		 3hecA-3eeaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  65
LYS A  67
GLU A  89
LEU A  92
LEU A  93
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
MG  A 314 ( 4.8A)
 0.73A 3hecA-3f2aA:
20.7		 3hecA-3f2aA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  65
LYS A  67
GLU A  89
LEU A  93
ILE A 104
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.60A 3hecA-3f2aA:
20.7		 3hecA-3f2aA:
24.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		9 ALA A  51
GLU A  71
LEU A  74
LEU A  75
THR A 106
LEU A 108
LEU A 167
ASP A 168
PHE A 169
 NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
NIL  A   1 (-4.0A)
NIL  A   1 (-4.6A)
NIL  A   1 (-3.5A)
 0.70A 3hecA-3gp0A:
41.8		 3hecA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  51
GLU A  71
LEU A  75
ILE A  84
THR A 106
LEU A 167
ASP A 168
PHE A 169
 NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.0A)
NIL  A   1 (-4.6A)
NIL  A   1 (-3.5A)
 0.67A 3hecA-3gp0A:
41.8		 3hecA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  51
LEU A  78
LEU A  75
ILE A  84
THR A 106
LEU A 167
 NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.0A)
 1.49A 3hecA-3gp0A:
41.8		 3hecA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  51
LYS A  53
THR A 106
LEU A 108
LEU A 167
ASP A 168
 NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
NIL  A   1 (-4.0A)
NIL  A   1 (-4.6A)
 0.73A 3hecA-3gp0A:
41.8		 3hecA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  30
ALA A  51
GLU A  71
LEU A  74
LEU A  75
THR A 106
LEU A 108
ASP A 168
PHE A 169
 None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
NIL  A   1 (-4.6A)
NIL  A   1 (-3.5A)
 0.82A 3hecA-3gp0A:
41.8		 3hecA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  51
LYS A  53
THR A 106
LEU A 108
ASP A 168
 None
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
NIL  A   1 (-4.6A)
 0.61A 3hecA-3gp0A:
41.8		 3hecA-3gp0A:
75.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 859
GLU A 878
LEU A 882
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
8ST  A2001 ( 3.7A)
 0.67A 3hecA-3hngA:
20.9		 3hecA-3hngA:
26.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 453
LYS A 455
GLU A 468
LEU A 472
LEU A 500
 ANP  A 400 ( 3.8A)
None
None
None
ANP  A 400 (-4.6A)
 0.74A 3hecA-3kn5A:
18.2		 3hecA-3kn5A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 ALA A 700
GLU A 715
LEU A 719
ILE A 729
LEU A 747
 ADP  A2101 (-3.5A)
None
None
None
None
 0.86A 3hecA-3lj0A:
19.9		 3hecA-3lj0A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 ALA A 700
LYS A 702
GLU A 715
ILE A 729
LEU A 747
 ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
None
 0.73A 3hecA-3lj0A:
19.9		 3hecA-3lj0A:
27.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ALA A  57
LYS A  59
GLU A  77
LEU A  81
ILE A  90
 ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
ANP  A 430 ( 4.4A)
None
ANP  A 430 ( 4.5A)
 0.74A 3hecA-3nieA:
33.5		 3hecA-3nieA:
33.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ALA A 213
LYS A 215
GLU A 234
LEU A 238
LEU A 265
 AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
 0.54A 3hecA-3nyoA:
22.4		 3hecA-3nyoA:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		5 ALA A  52
ILE A  85
THR A 107
LEU A 109
PHE A 170
 1N1  A1000 (-3.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
1N1  A1000 (-4.5A)
 0.71A 3hecA-3ohtA:
35.2		 3hecA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		5 ALA A  52
ILE A  85
THR A 107
LEU A 168
PHE A 170
 1N1  A1000 (-3.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 ( 3.7A)
1N1  A1000 (-4.5A)
 0.85A 3hecA-3ohtA:
35.2		 3hecA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		9 VAL A  31
ALA A  52
LYS A  54
GLU A  72
LEU A  75
LEU A  76
ILE A  85
THR A 107
LEU A 168
 1N1  A1000 ( 4.3A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
None
1N1  A1000 (-4.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 ( 3.7A)
 0.63A 3hecA-3ohtA:
35.2		 3hecA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		8 VAL A  31
ALA A  52
LYS A  54
GLU A  72
LEU A  76
ILE A  85
THR A 107
LEU A 109
 1N1  A1000 ( 4.3A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
 0.64A 3hecA-3ohtA:
35.2		 3hecA-3ohtA:
87.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 373
LYS A 375
GLU A 393
LEU A 397
THR A 421
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-4.4A)
 0.65A 3hecA-3omvA:
20.6		 3hecA-3omvA:
27.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		5 ALA A  49
LEU A  81
LEU A  82
THR A 112
LEU A 114
 None
 0.60A 3hecA-3pg1A:
25.1		 3hecA-3pg1A:
37.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 ALA A  84
LYS A  86
GLU A 115
LEU A 118
LEU A 119
ILE A 128
THR A 144
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
None
None
ANP  A1634 (-4.6A)
 0.78A 3hecA-3q5iA:
22.4		 3hecA-3q5iA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA B 616
LYS B 618
GLU B 635
LEU B 639
LEU B 888
 None
 0.52A 3hecA-3qd2B:
21.1		 3hecA-3qd2B:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  10
ALA A  31
LYS A  33
GLU A  50
LEU A  54
 38R  A 350 (-4.4A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
 0.72A 3hecA-3zduA:
21.9		 3hecA-3zduA:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  82
GLU A 102
LEU A 106
ILE A 115
LEU A 139
 R4L  A1394 ( 3.7A)
None
None
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
 0.88A 3hecA-4b99A:
35.9		 3hecA-4b99A:
41.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  82
LEU A 106
ILE A 115
LEU A 139
ASP A 200
 R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
 0.73A 3hecA-4b99A:
35.9		 3hecA-4b99A:
41.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  82
LYS A  84
ILE A 115
LEU A 139
ASP A 200
 R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
 0.63A 3hecA-4b99A:
35.9		 3hecA-4b99A:
41.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		5 ALA A 267
LYS A 269
GLU A 288
LEU A 292
ILE A 302
 None
 0.80A 3hecA-4c0tA:
22.4		 3hecA-4c0tA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
LYS A 655
GLU A 672
ILE A 685
THR A 701
ASP A 784
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.1A)
 0.50A 3hecA-4ckrA:
21.4		 3hecA-4ckrA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
LYS A 655
GLU A 672
THR A 701
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.87A 3hecA-4ckrA:
21.4		 3hecA-4ckrA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfc UVRABC SYSTEM
PROTEIN A

(Escherichia
coli) 		no annotation 5 ALA B 224
LEU B 166
LEU B 169
ILE B 154
LEU B 225
 None
 1.03A 3hecA-4dfcB:
undetectable		 3hecA-4dfcB:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		5 ALA A 218
LYS A 220
GLU A 239
LEU A 243
LEU A 273
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
None
29X  A 702 (-4.6A)
 0.51A 3hecA-4mk0A:
22.7		 3hecA-4mk0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  67
LYS A  69
GLU A  85
THR A 123
LEU A 125
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.8A)
 0.34A 3hecA-4o38A:
18.1		 3hecA-4o38A:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 ALA A  49
LYS A  51
GLU A  70
LEU A  73
LEU A  74
 ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
ANP  A 402 (-3.0A)
None
None
 0.66A 3hecA-4qnyA:
32.8		 3hecA-4qnyA:
38.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 ALA A  49
LYS A  51
GLU A  70
LEU A  74
ILE A  83
 ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
ANP  A 402 (-3.0A)
None
ANP  A 402 (-4.8A)
 0.57A 3hecA-4qnyA:
32.8		 3hecA-4qnyA:
38.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		5 GLU B  71
LEU B  75
ILE B  84
LEU B 167
ASP B 168
 39G  B 401 (-3.4A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 0.79A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU B  75
ILE B  84
THR B 106
LEU B 167
ASP B 168
 39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 0.81A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		6 LYS B  53
ILE B  84
THR B 106
LEU B 108
LEU B 167
ASP B 168
 39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 0.85A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL B  30
ALA B  51
LEU B  74
ILE B  84
THR B 106
LEU B 108
LEU B 167
 None
39G  B 401 (-3.5A)
None
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
 0.59A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL B  30
ALA B  51
LEU B  74
LEU B  75
ILE B  84
THR B 106
LEU B 167
 None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
 0.63A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL B  30
ALA B  51
LYS B  53
ILE B  84
THR B 106
LEU B 108
LEU B 167
 None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
 0.65A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL B  30
GLU B  71
LEU B  74
LEU B  75
ILE B  84
LEU B 167
 None
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
 0.66A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 488
LYS A 490
GLU A 509
LEU A 513
THR A 539
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 (-2.8A)
 0.49A 3hecA-4yffA:
19.7		 3hecA-4yffA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ALA A  55
LYS A  57
GLU A  76
LEU A  80
THR A 105
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 0.77A 3hecA-4ysjA:
15.2		 3hecA-4ysjA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LYS A  57
GLU A  76
LEU A  79
LEU A  80
THR A 105
 ADP  A 506 (-2.4A)
None
None
None
ADP  A 506 ( 4.6A)
 1.01A 3hecA-4ysjA:
15.2		 3hecA-4ysjA:
25.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 ALA A  51
ILE A  84
LEU A 108
LEU A 166
ASP A 167
 ANP  A 401 (-3.5A)
None
ANP  A 401 ( 4.8A)
ANP  A 401 ( 4.5A)
None
 1.00A 3hecA-5awmA:
35.7		 3hecA-5awmA:
44.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 ALA A  51
LYS A  53
ILE A  84
LEU A 108
ASP A 167
 ANP  A 401 (-3.5A)
ANP  A 401 (-2.9A)
None
ANP  A 401 ( 4.8A)
None
 0.63A 3hecA-5awmA:
35.7		 3hecA-5awmA:
44.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  31
ALA A  52
LYS A  54
GLU A  69
LEU A  73
 VAL  A  31 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
 0.48A 3hecA-5d7aA:
17.9		 3hecA-5d7aA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A 352
LYS A 347
LEU A 328
LEU A 325
LEU A 344
 None
CAS  A 346 ( 2.8A)
None
CAS  A 346 ( 4.8A)
None
 1.03A 3hecA-5dbxA:
19.2		 3hecA-5dbxA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 250
ALA A 275
LYS A 277
GLU A 290
THR A 325
 STU  A 601 (-3.9A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
 0.59A 3hecA-5e8yA:
16.4		 3hecA-5e8yA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		5 ALA A 561
ILE A 595
THR A 611
LEU A 613
ASP A 675
 4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
None
 0.75A 3hecA-5ezrA:
20.3		 3hecA-5ezrA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		5 ALA A 561
LYS A 563
ILE A 595
THR A 611
LEU A 613
 4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
 0.65A 3hecA-5ezrA:
20.3		 3hecA-5ezrA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA C  44
LYS C  46
GLU C  60
LEU C  63
LEU C  92
 None
 0.74A 3hecA-5fqdC:
15.1		 3hecA-5fqdC:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
LYS A 627
GLU A 644
THR A 674
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.66A 3hecA-5grnA:
17.5		 3hecA-5grnA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		6 ALA A 356
LYS A 358
GLU A 411
THR A 445
LEU A 447
LEU A 506
 ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
None
ANP  A 700 (-4.1A)
ANP  A 700 ( 4.5A)
ANP  A 700 ( 4.3A)
 0.85A 3hecA-5i35A:
7.4		 3hecA-5i35A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 ALA A 340
THR A 282
LEU A 278
ASP A 319
PHE A 322
 HEM  A 401 (-4.7A)
None
None
None
None
 1.03A 3hecA-5it1A:
undetectable		 3hecA-5it1A:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 417
LYS A 419
GLU A 436
LEU A 440
LEU A 467
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 ( 4.7A)
 0.76A 3hecA-5jznA:
23.4		 3hecA-5jznA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 5 ALA A  65
LYS A  67
GLU A  89
LEU A  92
LEU A  93
 7LK  A 401 (-3.3A)
None
None
None
None
 0.74A 3hecA-5turA:
21.0		 3hecA-5turA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ALA A 218
LYS A 220
GLU A 239
LEU A 243
LEU A 273
 QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 (-3.9A)
None
None
 0.49A 3hecA-5uuuA:
22.9		 3hecA-5uuuA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 137
LYS A 139
GLU A 157
THR A 187
LEU A 189
 H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
None
 0.79A 3hecA-5vcxA:
18.1		 3hecA-5vcxA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 VAL A 455
ILE A 481
THR A 469
LEU A 467
LEU A 395
 None
 1.09A 3hecA-5w81A:
undetectable		 3hecA-5w81A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ALA A  70
LYS A  72
GLU A  85
LEU A  89
ILE A  99
 ATP  A 403 (-3.4A)
ATP  A 403 (-3.2A)
None
None
ATP  A 403 (-4.9A)
 0.66A 3hecA-5xvuA:
25.0		 3hecA-5xvuA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A 204
ALA A 225
LYS A 227
GLU A 244
LEU A 248
 None
 0.63A 3hecA-5xzwA:
18.2		 3hecA-5xzwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 ALA A 236
LYS A 238
GLU A 253
ILE A 272
LEU A 290
 HRM  A 601 (-3.5A)
HRM  A 601 (-3.3A)
HRM  A 601 ( 4.6A)
HRM  A 601 ( 4.8A)
HRM  A 601 (-4.6A)
 0.63A 3hecA-5y86A:
21.9		 3hecA-5y86A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cno INTERMEDIATE
CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 4

(Homo sapiens) 		no annotation 5 LEU A 217
ILE A 244
THR A 270
LEU A 268
LEU A 223
 None
 1.04A 3hecA-6cnoA:
undetectable		 3hecA-6cnoA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 5 ALA A 191
LYS A 193
GLU A 208
LEU A 212
LEU A 245
 3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
3NG  A 501 ( 4.7A)
 0.55A 3hecA-6fylA:
25.2		 3hecA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 ALA A 189
LYS A 191
GLU A 206
LEU A 210
LEU A 243
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
3NG  A 501 ( 4.7A)
 0.60A 3hecA-6fyvA:
25.2		 3hecA-6fyvA:
undetectable