SIMILAR PATTERNS OF AMINO ACIDS FOR 3HCR_A_CHDA424

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 ARG A 292
PRO A 340
GLY A 336
PRO A 337
 NAD  A 600 (-3.1A)
None
None
None
 0.82A 3hcrA-1ad3A:
2.2		 3hcrA-1ad3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus) 		PF00079
(Serpin) 		4 LEU A 103
PRO A  20
GLY A 354
PRO A 353
 None
 1.07A 3hcrA-1attA:
undetectable		 3hcrA-1attA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 459
ARG A 157
PRO A 367
SER A 370
 None
 1.14A 3hcrA-1gycA:
undetectable		 3hcrA-1gycA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		4 ARG A 409
PRO A 359
GLY A 300
PRO A 299
 None
 1.06A 3hcrA-1irxA:
undetectable		 3hcrA-1irxA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mns MANDELATE RACEMASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 306
ARG A 282
SER A  49
PRO A  80
 None
 1.00A 3hcrA-1mnsA:
undetectable		 3hcrA-1mnsA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 LEU X 564
ARG X 169
GLY X 176
MET X 178
 None
 1.12A 3hcrA-1mw9X:
3.4		 3hcrA-1mw9X:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 4 LEU A 226
PRO A 161
GLY A 186
PRO A 187
 None
 0.78A 3hcrA-1onsA:
2.4		 3hcrA-1onsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 277
SER A  73
GLY A  28
PRO A  27
 None
 0.83A 3hcrA-1qgdA:
3.5		 3hcrA-1qgdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rv9 CONSERVED
HYPOTHETICAL PROTEIN
NMB0706

(Neisseria
meningitidis) 		PF02578
(Cu-oxidase_4) 		4 LEU A 146
ARG A 211
SER A 250
GLY A 224
 None
 1.13A 3hcrA-1rv9A:
undetectable		 3hcrA-1rv9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw0 CONSERVED
HYPOTHETICAL PROTEIN

(Salmonella
enterica) 		PF02578
(Cu-oxidase_4) 		4 LEU A 135
ARG A 199
SER A 238
GLY A 212
 None
 1.08A 3hcrA-1rw0A:
undetectable		 3hcrA-1rw0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb7 TRNA PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF01142
(TruD) 		4 ARG A 247
PRO A 325
SER A 328
GLY A 229
 None
 1.00A 3hcrA-1sb7A:
undetectable		 3hcrA-1sb7A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 PRO A1255
SER A1176
GLY A1248
PRO A1249
 None
FAD  A1452 (-3.7A)
None
NAP  A1453 (-4.2A)
 0.69A 3hcrA-1tllA:
4.1		 3hcrA-1tllA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN

(Shigella
flexneri) 		PF02578
(Cu-oxidase_4) 		4 LEU A 135
ARG A 199
SER A 238
GLY A 212
 None
 1.10A 3hcrA-1u05A:
undetectable		 3hcrA-1u05A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		4 LEU A 194
ARG A 154
PRO A 142
GLY A 181
 None
None
None
PO4  A1226 (-3.6A)
 0.91A 3hcrA-1w0mA:
2.2		 3hcrA-1w0mA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ARG A 481
PRO A 530
GLY A1000
PRO A1001
 None
 0.78A 3hcrA-1yq2A:
undetectable		 3hcrA-1yq2A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 LEU A  34
ARG A 241
GLY A 335
PRO A 336
 None
 1.08A 3hcrA-2ahwA:
undetectable		 3hcrA-2ahwA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		4 PRO A 185
SER A 142
GLY A 216
MET A 187
 NAD  A1251 (-3.5A)
KPC  A1252 (-3.5A)
None
NAD  A1251 (-3.8A)
 1.09A 3hcrA-2cfcA:
3.4		 3hcrA-2cfcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ARG A 227
PRO A 254
SER A 644
PRO A 232
 None
 1.00A 3hcrA-2ecfA:
2.9		 3hcrA-2ecfA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 LEU A 594
PRO A 544
SER A 566
GLY A 627
 None
 1.06A 3hcrA-2eidA:
undetectable		 3hcrA-2eidA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		4 LEU A  50
ARG A  32
GLY A  66
PRO A  67
 None
 1.10A 3hcrA-2epjA:
2.6		 3hcrA-2epjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsd 3-ALPHA, 20
BETA-HYDROXYSTEROID
DEHYDROGENASE

(Streptomyces
exfoliatus) 		PF13561
(adh_short_C2) 		4 PRO A 182
SER A 139
GLY A 211
MET A 184
 NAD  A 256 (-4.0A)
NAD  A 256 (-3.4A)
None
None
 1.12A 3hcrA-2hsdA:
2.9		 3hcrA-2hsdA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j28 50S RIBOSOMAL
PROTEIN L2

(Escherichia
coli) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 LEU C  80
SER C 156
GLY C 126
PRO C 125
 None
 0.98A 3hcrA-2j28C:
undetectable		 3hcrA-2j28C:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myi EXODEOXYRIBONUCLEASE
III

(Pseudomonas sp.
Lz4W) 		PF03372
(Exo_endo_phos) 		4 ARG A  37
PRO A 110
SER A 148
GLY A  66
 None
 1.01A 3hcrA-2myiA:
undetectable		 3hcrA-2myiA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		4 LEU A 450
ARG A 445
SER A  47
PRO A 766
 None
None
ADP  A1843 (-3.6A)
None
 1.00A 3hcrA-2vf8A:
undetectable		 3hcrA-2vf8A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		4 SER A 227
GLY A 261
PRO A 262
MET A 263
 BGC  A1337 (-4.7A)
None
GOL  A1341 ( 4.7A)
BGC  A1337 (-4.5A)
 1.04A 3hcrA-2wabA:
3.6		 3hcrA-2wabA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 116
PRO A  26
SER A  34
GLY A  22
 GOL  A1726 ( 4.8A)
None
None
None
 1.00A 3hcrA-2x40A:
2.1		 3hcrA-2x40A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE-1 RESTRICTION
ENZYME ECOKI
SPECIFICITY PROTEIN

(Escherichia
coli) 		PF01420
(Methylase_S) 		4 LEU A 444
ARG A 451
SER A 412
GLY A 420
 None
 1.04A 3hcrA-2y7cA:
undetectable		 3hcrA-2y7cA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 298
PRO A 263
SER A 272
GLY A 290
 None
 1.04A 3hcrA-2zc8A:
3.0		 3hcrA-2zc8A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 ARG A 248
ARG A 247
GLY A 598
PRO A 597
 None
 1.10A 3hcrA-2zj8A:
3.7		 3hcrA-2zj8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF06751
(EutB)
PF05985
(EutC) 		4 LEU A 396
SER A 182
GLY B  84
PRO B  85
 None
 0.95A 3hcrA-3anyA:
undetectable		 3hcrA-3anyA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		4 LEU A 101
ARG A 114
PRO A 266
GLY A 306
 CHD  A   3 ( 4.9A)
CHD  A   2 (-3.6A)
CHD  A   2 ( 4.5A)
CHD  A   2 ( 3.8A)
 0.78A 3hcrA-3aqiA:
53.5		 3hcrA-3aqiA:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		4 LEU A 101
PRO A 266
GLY A 306
PRO A 307
 CHD  A   3 ( 4.9A)
CHD  A   2 ( 4.5A)
CHD  A   2 ( 3.8A)
None
 0.62A 3hcrA-3aqiA:
53.5		 3hcrA-3aqiA:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 PRO A 266
SER A 268
GLY A 306
PRO A 307
MET A 308
 CHD  A   2 ( 4.5A)
CHD  A   2 ( 4.4A)
CHD  A   2 ( 3.8A)
None
None
 0.25A 3hcrA-3aqiA:
53.5		 3hcrA-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN
POLYPROTEIN

(Senecavirus A;
Senecavirus A) 		no annotation
PF00073
(Rhv) 		4 LEU C 141
SER A 250
GLY C 190
PRO C 191
 None
 1.11A 3hcrA-3cjiC:
undetectable		 3hcrA-3cjiC:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		4 LEU A 398
PRO A  86
GLY A  61
PRO A  62
 None
 0.96A 3hcrA-3d5eA:
2.9		 3hcrA-3d5eA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxp PUTATIVE ACYL-COA
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF01636
(APH) 		4 LEU A  92
ARG A  84
ARG A  87
GLY A 165
 None
 1.12A 3hcrA-3dxpA:
undetectable		 3hcrA-3dxpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		4 LEU A  90
ARG A  70
PRO A 123
SER A 169
 None
None
None
EDO  A1001 ( 4.5A)
 0.95A 3hcrA-3e3xA:
undetectable		 3hcrA-3e3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4d ESTERASE D

(Agrobacterium
fabrum) 		PF00756
(Esterase) 		4 PRO A 176
SER A 182
GLY A 152
MET A 148
 None
 1.09A 3hcrA-3e4dA:
3.2		 3hcrA-3e4dA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		4 LEU B 111
ARG A 154
PRO A1115
GLY A1181
 None
 1.15A 3hcrA-3egwB:
undetectable		 3hcrA-3egwB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		4 PRO A 269
GLY A 241
PRO A 242
MET A 243
 None
 1.03A 3hcrA-3fbsA:
undetectable		 3hcrA-3fbsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		4 PRO A 405
SER A 408
PRO A 423
MET A 422
 None
 1.14A 3hcrA-3fcrA:
2.1		 3hcrA-3fcrA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Geobacter
metallireducens) 		PF00155
(Aminotran_1_2) 		4 ARG A 280
PRO A 112
GLY A 161
PRO A 162
 None
 0.83A 3hcrA-3hdoA:
undetectable		 3hcrA-3hdoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibr BACTERIOPHYTOCHROME

(Pseudomonas
aeruginosa) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 LEU A 356
ARG A 362
PRO A 342
GLY A 337
 None
 1.04A 3hcrA-3ibrA:
undetectable		 3hcrA-3ibrA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijp DIHYDRODIPICOLINATE
REDUCTASE

(Bartonella
henselae) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 ARG A 177
PRO A 162
SER A 163
GLY A 202
 None
None
UNX  A 271 ( 4.9A)
None
 1.14A 3hcrA-3ijpA:
2.5		 3hcrA-3ijpA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l07 BIFUNCTIONAL PROTEIN
FOLD

(Francisella
tularensis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 LEU A   3
GLY A 262
PRO A 263
MET A 264
 None
IMD  A 503 ( 3.8A)
IMD  A 503 (-4.3A)
None
 1.06A 3hcrA-3l07A:
2.3		 3hcrA-3l07A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		4 ARG A 365
SER A 259
GLY A 134
PRO A 135
 None
MG  A 408 ( 4.0A)
None
None
 0.55A 3hcrA-3lopA:
5.4		 3hcrA-3lopA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 LEU A 106
PRO A 307
SER A 305
GLY A 351
 None
 0.96A 3hcrA-3m6xA:
undetectable		 3hcrA-3m6xA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 152
SER A 411
GLY A 428
PRO A 429
 None
 1.00A 3hcrA-3mogA:
2.7		 3hcrA-3mogA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 ARG A 292
PRO A 340
GLY A 336
PRO A 337
 None
 0.92A 3hcrA-3szbA:
2.2		 3hcrA-3szbA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 296
SER A  93
GLY A  48
PRO A  47
 None
 0.82A 3hcrA-3uk1A:
2.6		 3hcrA-3uk1A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6o DYNAMIN-1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 LEU A  50
GLY A  -1
PRO A   0
MET A   1
 None
 1.11A 3hcrA-3w6oA:
2.2		 3hcrA-3w6oA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6o DYNAMIN-1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 LEU A  65
GLY A  -1
PRO A   0
MET A   1
 None
 0.59A 3hcrA-3w6oA:
2.2		 3hcrA-3w6oA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 481
ARG A 178
PRO A 389
SER A 392
 None
 1.15A 3hcrA-3x1bA:
undetectable		 3hcrA-3x1bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 108
GLY A 206
PRO A 207
MET A 208
 NDP  A 601 ( 4.6A)
NDP  A 601 (-3.8A)
None
None
 1.02A 3hcrA-3zhyA:
3.0		 3hcrA-3zhyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 614
ARG A 559
PRO A 658
GLY A 649
 None
 1.02A 3hcrA-4ay2A:
4.0		 3hcrA-4ay2A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		4 LEU A 103
SER A  96
GLY A 465
PRO A 466
 None
 0.87A 3hcrA-4c60A:
undetectable		 3hcrA-4c60A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 PRO A 945
SER A 943
GLY A 790
PRO A 791
 None
 1.16A 3hcrA-4cakA:
undetectable		 3hcrA-4cakA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA

(Brucella
abortus) 		PF00677
(Lum_binding) 		4 LEU A 127
ARG A 116
SER A  44
GLY A 175
 None
 1.02A 3hcrA-4e0fA:
undetectable		 3hcrA-4e0fA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 277
PRO A 220
SER A 247
GLY A 217
 None
 1.00A 3hcrA-4eutA:
undetectable		 3hcrA-4eutA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4w DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		4 ARG A 280
ARG A 243
SER A 298
GLY A 247
 None
 1.11A 3hcrA-4f4wA:
undetectable		 3hcrA-4f4wA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 PRO A 293
SER A 180
GLY A 536
PRO A 535
 None
 0.90A 3hcrA-4fnqA:
undetectable		 3hcrA-4fnqA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwi ABC-TYPE
DIPEPTIDE/OLIGOPEPTI
DE/NICKEL TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00005
(ABC_tran)
PF08352
(oligo_HPY) 		4 LEU B 278
ARG B  11
PRO B 289
GLY B 284
 ATP  B 402 ( 4.9A)
None
None
None
 1.09A 3hcrA-4fwiB:
undetectable		 3hcrA-4fwiB:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		4 LEU A 400
ARG A 380
ARG A 383
GLY A 354
 None
 1.04A 3hcrA-4fx5A:
4.8		 3hcrA-4fx5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		4 LEU A 246
SER A 342
GLY A 439
PRO A 440
 None
 0.85A 3hcrA-4j9uA:
undetectable		 3hcrA-4j9uA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU A 277
PRO A 220
SER A 247
GLY A 217
 None
 1.14A 3hcrA-4jlcA:
undetectable		 3hcrA-4jlcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  48
PRO A  78
SER A  74
GLY A 270
 None
 0.85A 3hcrA-4jn7A:
2.0		 3hcrA-4jn7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 LEU A 176
PRO A  99
GLY A 120
PRO A 119
 None
 1.15A 3hcrA-4ka8A:
undetectable		 3hcrA-4ka8A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m18 PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN D

(Homo sapiens) 		PF00059
(Lectin_C)
PF09006
(Surfac_D-trimer) 		4 LEU A 268
ARG A 349
SER A 298
GLY A 346
 None
MAN  A 407 (-3.9A)
None
None
 1.16A 3hcrA-4m18A:
undetectable		 3hcrA-4m18A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc0 PUTATIVE
SESQUITERPENE
CYCLASE

(Kitasatospora
setae) 		no annotation 4 LEU A 284
GLY A 204
PRO A 205
MET A 206
 None
 1.14A 3hcrA-4mc0A:
undetectable		 3hcrA-4mc0A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		4 ARG A  67
PRO A 119
GLY A  59
MET A  57
 None
 1.09A 3hcrA-4mt1A:
undetectable		 3hcrA-4mt1A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of8 IRREGULAR CHIASM
C-ROUGHEST PROTEIN

(Drosophila
melanogaster) 		PF07679
(I-set)
PF08205
(C2-set_2) 		4 LEU A  67
PRO A  34
SER A 121
GLY A 125
 None
None
None
GOL  A 302 (-3.6A)
 0.87A 3hcrA-4of8A:
undetectable		 3hcrA-4of8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pug BOLA LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01722
(BolA) 		4 LEU A  85
PRO A 153
SER A 156
GLY A 118
 None
 1.13A 3hcrA-4pugA:
undetectable		 3hcrA-4pugA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		4 ARG A 289
PRO A 123
SER A 121
GLY A 334
 None
 1.14A 3hcrA-4q3rA:
3.1		 3hcrA-4q3rA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 ARG A 290
PRO A 338
GLY A 334
PRO A 335
 None
 0.87A 3hcrA-4qgkA:
2.2		 3hcrA-4qgkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon) 		4 LEU A 564
ARG A 169
GLY A 176
MET A 178
 None
SO4  A1005 (-2.7A)
None
None
 1.15A 3hcrA-4rulA:
2.7		 3hcrA-4rulA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A 753
ARG A 735
PRO A 719
GLY A 771
 None
 1.09A 3hcrA-4xgtA:
3.5		 3hcrA-4xgtA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		4 ARG A 279
SER A 401
GLY A 396
PRO A 397
 None
 0.91A 3hcrA-5fg3A:
2.1		 3hcrA-5fg3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		4 LEU A 114
SER A 221
GLY A 332
PRO A 333
 None
 1.15A 3hcrA-5fubA:
undetectable		 3hcrA-5fubA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 LEU A 341
PRO A 410
SER A 411
GLY A 237
 None
 1.12A 3hcrA-5fv4A:
2.9		 3hcrA-5fv4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 272
PRO A 308
SER A 310
GLY A 282
 None
None
NAG  A 805 ( 4.8A)
SO4  A 807 (-3.9A)
 1.08A 3hcrA-5gr8A:
undetectable		 3hcrA-5gr8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		4 LEU A 350
GLY A 394
PRO A 395
MET A 396
 None
 1.06A 3hcrA-5gyzA:
2.4		 3hcrA-5gyzA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ARG A 244
PRO A 215
SER A 286
MET A 263
 BLA  A 601 (-3.0A)
None
None
None
 1.04A 3hcrA-5i5lA:
undetectable		 3hcrA-5i5lA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		4 LEU A 402
PRO A 435
SER A 437
GLY A  19
 None
None
None
FAD  A 601 (-3.3A)
 1.08A 3hcrA-5j7xA:
undetectable		 3hcrA-5j7xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kr6 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		4 PRO A 405
SER A 408
PRO A 422
MET A 421
 None
 1.13A 3hcrA-5kr6A:
undetectable		 3hcrA-5kr6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 350
GLY A 394
PRO A 395
MET A 396
 None
 1.11A 3hcrA-5kyvA:
2.4		 3hcrA-5kyvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr1 FTSZ-BINDING PROTEIN
FZLA

(Caulobacter
vibrioides) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 LEU A 125
PRO A  41
PRO A  53
MET A  52
 None
 1.11A 3hcrA-5nr1A:
undetectable		 3hcrA-5nr1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 4 ARG A 105
PRO A 191
GLY A 382
PRO A 383
 None
 1.16A 3hcrA-5oc1A:
2.1		 3hcrA-5oc1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 4 LEU A 301
ARG A 193
SER A 249
GLY A 151
 None
 0.88A 3hcrA-5txfA:
3.4		 3hcrA-5txfA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		4 LEU A   4
PRO A 174
GLY A 153
PRO A 152
 None
 0.92A 3hcrA-5u0lA:
2.3		 3hcrA-5u0lA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 ARG A 294
PRO A 344
GLY A 340
PRO A 341
 None
 0.86A 3hcrA-5ucdA:
2.2		 3hcrA-5ucdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00258
(Flavodoxin_1)
PF01392
(Fz)
PF01534
(Frizzled) 		4 LEU A 125
ARG A 168
ARG A 173
GLY A  94
 None
 0.79A 3hcrA-5v57A:
3.7		 3hcrA-5v57A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 4 ARG A 598
SER A 682
GLY A 690
PRO A 691
 None
 1.08A 3hcrA-5v9xA:
3.0		 3hcrA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 4 LEU A 410
ARG A 400
SER A 380
GLY A 394
 None
None
C2F  A3001 (-4.7A)
None
 0.86A 3hcrA-5vopA:
2.1		 3hcrA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wte VP3

(Hepatovirus A) 		PF00073
(Rhv) 		4 LEU C 115
ARG C 182
GLY C 138
PRO C 137
 None
 1.07A 3hcrA-5wteC:
undetectable		 3hcrA-5wteC:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 LEU A 646
PRO A 544
SER A 545
GLY A 493
 None
EDO  A1804 (-4.8A)
EDO  A1804 (-3.8A)
None
 1.08A 3hcrA-5x7sA:
undetectable		 3hcrA-5x7sA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 LEU A   8
GLY A 267
PRO A 268
MET A 269
 None
 0.99A 3hcrA-6apeA:
3.0		 3hcrA-6apeA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 4 ARG A 587
PRO A 182
SER A  16
GLY A 318
 None
 1.11A 3hcrA-6bo6A:
undetectable		 3hcrA-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 LEU A 601
ARG A 347
GLY A 278
PRO A 277
 None
None
CA  A 904 ( 4.6A)
G39  A 908 ( 4.4A)
 1.04A 3hcrA-6eksA:
undetectable		 3hcrA-6eksA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et0 PQSB

(Pseudomonas
aeruginosa) 		no annotation 4 LEU B 176
SER B 130
GLY B 239
PRO B 240
 None
 0.99A 3hcrA-6et0B:
undetectable		 3hcrA-6et0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f71 GLUTATHIONE
TRANSFERASE

(Trametes
versicolor) 		no annotation 4 PRO A 101
SER A 102
GLY A 158
PRO A 159
 None
 1.15A 3hcrA-6f71A:
undetectable		 3hcrA-6f71A:
undetectable