SIMILAR PATTERNS OF AMINO ACIDS FOR 3HCP_B_CHDB4_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		3 GLY A  98
PRO A 124
LEU A 119
 None
 0.63A 3hcpB-1a88A:
2.8		 3hcpB-1a88A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwm PROTEIN (ALPHA-BETA
T CELL RECEPTOR
(TCR) (D10))

(Mus musculus) 		PF07686
(V-set) 		3 GLY A 399
PRO A 333
LEU A 404
 None
 0.61A 3hcpB-1bwmA:
undetectable		 3hcpB-1bwmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		3 GLY A 118
PRO A 121
LEU A 206
 None
 0.58A 3hcpB-1fd9A:
undetectable		 3hcpB-1fd9A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		3 GLY A 385
PRO A 359
LEU A   3
 None
 0.63A 3hcpB-1fp9A:
0.6		 3hcpB-1fp9A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i31 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		3 GLY A 332
PRO A 327
LEU A 372
 None
 0.54A 3hcpB-1i31A:
undetectable		 3hcpB-1i31A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibz NITROSOCYANIN

(Nitrosomonas
europaea) 		PF13473
(Cupredoxin_1) 		3 GLY A 106
PRO A  37
LEU A  40
 None
 0.61A 3hcpB-1ibzA:
undetectable		 3hcpB-1ibzA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		3 GLY A 341
PRO A 335
LEU A 343
 None
 0.64A 3hcpB-1jaeA:
0.0		 3hcpB-1jaeA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		3 GLY A 422
PRO A 438
LEU A 416
 None
 0.58A 3hcpB-1k25A:
0.0		 3hcpB-1k25A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		3 GLY A 158
PRO A 162
LEU A 247
 None
 0.60A 3hcpB-1kt1A:
undetectable		 3hcpB-1kt1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Gallus gallus) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 GLY A 230
PRO A  10
LEU A 195
 None
 0.63A 3hcpB-1ktcA:
3.1		 3hcpB-1ktcA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		3 GLY A  99
PRO A 103
LEU A 316
 None
 0.45A 3hcpB-1lbqA:
48.1		 3hcpB-1lbqA:
49.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		3 GLY A 442
PRO A 430
LEU A 488
 None
 0.54A 3hcpB-1lf9A:
undetectable		 3hcpB-1lf9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mec MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP1)

(Cardiovirus A) 		no annotation 3 GLY 1  56
PRO 1 154
LEU 1 165
 None
 0.58A 3hcpB-1mec1:
undetectable		 3hcpB-1mec1:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mmf GLYCEROL DEHYDRASE
BETA SUBUNIT

(Klebsiella
pneumoniae) 		PF02288
(Dehydratase_MU) 		3 GLY B  33
PRO B 184
LEU B  90
 None
 0.64A 3hcpB-1mmfB:
undetectable		 3hcpB-1mmfB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		3 GLY A  27
PRO A 379
LEU A  29
 None
 0.59A 3hcpB-1nr6A:
undetectable		 3hcpB-1nr6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLY A 282
PRO A 262
LEU A 306
 None
 0.61A 3hcpB-1nxkA:
undetectable		 3hcpB-1nxkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 GLY A 437
PRO A 440
LEU A 513
 CA  A 914 ( 4.0A)
None
None
 0.55A 3hcpB-1q5aA:
undetectable		 3hcpB-1q5aA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		3 GLY A 283
PRO A 334
LEU A 338
 None
SO4  A 803 (-4.4A)
None
 0.60A 3hcpB-1qfxA:
undetectable		 3hcpB-1qfxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw2 CONSERVED
HYPOTHETICAL PROTEIN
TA1206

(Thermoplasma
acidophilum) 		PF08827
(DUF1805) 		3 GLY A  58
PRO A  44
LEU A  46
 None
 0.58A 3hcpB-1qw2A:
undetectable		 3hcpB-1qw2A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		3 GLY A 377
PRO A 369
LEU A 379
 None
 0.64A 3hcpB-1sh2A:
undetectable		 3hcpB-1sh2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tme THEILER'S MURINE
ENCEPHALOMYELITIS
VIRUS (SUBUNIT VP2)

(Cardiovirus B) 		PF00073
(Rhv) 		3 GLY 2  90
PRO 2  85
LEU 2 100
 None
 0.62A 3hcpB-1tme2:
undetectable		 3hcpB-1tme2:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 GLY A 692
PRO A 695
LEU A 722
 None
 0.56A 3hcpB-1u1hA:
2.3		 3hcpB-1u1hA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 GLY A  37
PRO A 105
LEU A  31
 None
 0.63A 3hcpB-1v4gA:
undetectable		 3hcpB-1v4gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		3 GLY A 141
PRO A 125
LEU A 232
 None
 0.51A 3hcpB-1vi1A:
2.7		 3hcpB-1vi1A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		3 GLY A 158
PRO A 251
LEU A 236
 None
 0.64A 3hcpB-1vqvA:
undetectable		 3hcpB-1vqvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		3 GLY A 420
PRO A 411
LEU A 437
 CL  A 815 (-3.6A)
None
None
 0.60A 3hcpB-1w7cA:
undetectable		 3hcpB-1w7cA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN

(Thermus
thermophilus) 		PF02615
(Ldh_2) 		3 GLY A  45
PRO A 322
LEU A 185
 None
 0.61A 3hcpB-1x0aA:
undetectable		 3hcpB-1x0aA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		3 GLY A 334
PRO A 331
LEU A 303
 None
 0.63A 3hcpB-1x1qA:
2.6		 3hcpB-1x1qA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z47 PUTATIVE
ABC-TRANSPORTER
ATP-BINDING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 GLY A 196
PRO A 164
LEU A 167
 None
 0.49A 3hcpB-1z47A:
2.0		 3hcpB-1z47A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 GLY A 282
PRO A 267
LEU A 289
 None
 0.53A 3hcpB-1z8lA:
2.3		 3hcpB-1z8lA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 GLY B 271
PRO B 199
LEU B 265
 None
 0.59A 3hcpB-2amcB:
undetectable		 3hcpB-2amcB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avu FLAGELLAR
TRANSCRIPTIONAL
ACTIVATOR FLHC

(Escherichia
coli) 		PF05280
(FlhC) 		3 GLY E  55
PRO E  52
LEU E  26
 None
 0.60A 3hcpB-2avuE:
2.1		 3hcpB-2avuE:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9u HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Sulfurisphaera
tokodaii) 		PF00908
(dTDP_sugar_isom) 		3 GLY A  55
PRO A 153
LEU A 123
 None
 0.64A 3hcpB-2b9uA:
undetectable		 3hcpB-2b9uA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp5 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		3 GLY M 332
PRO M 327
LEU M 372
 None
 0.53A 3hcpB-2bp5M:
undetectable		 3hcpB-2bp5M:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9i GREEN FLUORESCENT
PROTEIN ASFP499

(Anemonia
sulcata) 		PF01353
(GFP) 		3 GLY A 152
PRO A 187
LEU A 154
 None
 0.58A 3hcpB-2c9iA:
undetectable		 3hcpB-2c9iA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 GLY A 194
PRO A 191
LEU A 171
 None
 0.55A 3hcpB-2ef0A:
5.9		 3hcpB-2ef0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		3 GLY A 336
PRO A 378
LEU A 373
 None
 0.52A 3hcpB-2euhA:
2.6		 3hcpB-2euhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6s CELL FILAMENTATION
PROTEIN, PUTATIVE

(Helicobacter
pylori) 		PF02661
(Fic) 		3 GLY A  47
PRO A  97
LEU A  31
 None
 0.60A 3hcpB-2f6sA:
undetectable		 3hcpB-2f6sA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft7 AZURIN

(Pseudomonas
aeruginosa) 		PF00127
(Copper-bind) 		3 GLY A  67
PRO A 114
LEU A  86
 None
CU1  A 200 ( 4.5A)
None
 0.45A 3hcpB-2ft7A:
undetectable		 3hcpB-2ft7A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		3 GLY A 265
PRO A 249
LEU A 285
 None
 0.58A 3hcpB-2hakA:
undetectable		 3hcpB-2hakA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hio PROTEIN (HISTONE
H2A)

(Gallus gallus) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		3 GLY A 106
PRO A 109
LEU A  85
 None
 0.63A 3hcpB-2hioA:
undetectable		 3hcpB-2hioA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		3 GLY A 284
PRO A 160
LEU A 195
 None
 0.61A 3hcpB-2i9kA:
2.8		 3hcpB-2i9kA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Porphyromonas
gingivalis) 		PF04095
(NAPRTase) 		3 GLY A 329
PRO A 310
LEU A 334
 None
 0.55A 3hcpB-2im5A:
undetectable		 3hcpB-2im5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is3 RIBONUCLEASE T

(Escherichia
coli) 		PF00929
(RNase_T) 		3 GLY A  67
PRO A  64
LEU A  70
 None
 0.62A 3hcpB-2is3A:
undetectable		 3hcpB-2is3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		3 GLY A 181
PRO A 234
LEU A   8
 None
 0.61A 3hcpB-2pgsA:
undetectable		 3hcpB-2pgsA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqk NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		3 GLY A 227
PRO A 235
LEU A 213
 None
 0.57A 3hcpB-2qqkA:
undetectable		 3hcpB-2qqkA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rr7 DYNEIN HEAVY CHAIN 9

(Chlamydomonas
reinhardtii) 		PF12777
(MT) 		3 GLY A  40
PRO A  37
LEU A  45
 None
 0.56A 3hcpB-2rr7A:
undetectable		 3hcpB-2rr7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		3 GLY A 512
PRO A 136
LEU A 131
 None
 0.34A 3hcpB-2v8jA:
undetectable		 3hcpB-2v8jA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 GLY D 833
PRO D 758
LEU D 786
 A  B  -5 ( 3.4A)
None
None
 0.56A 3hcpB-2vnuD:
undetectable		 3hcpB-2vnuD:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		3 GLY A 567
PRO A 472
LEU A 599
 None
 0.56A 3hcpB-2vuwA:
undetectable		 3hcpB-2vuwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vza CELL FILAMENTATION
PROTEIN

(Bartonella
henselae) 		PF02661
(Fic) 		3 GLY A 122
PRO A 160
LEU A 155
 None
 0.54A 3hcpB-2vzaA:
undetectable		 3hcpB-2vzaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLY C 270
PRO C 254
LEU C 290
 None
 0.60A 3hcpB-2wtkC:
undetectable		 3hcpB-2wtkC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLY B  67
PRO B  92
LEU B  63
 None
 0.58A 3hcpB-2wtkB:
undetectable		 3hcpB-2wtkB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		3 GLY A 169
PRO A 187
LEU A 193
 None
 0.63A 3hcpB-2xmoA:
undetectable		 3hcpB-2xmoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 GLY B 422
PRO B 438
LEU B 416
 None
 0.56A 3hcpB-2z2mB:
undetectable		 3hcpB-2z2mB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zt9 CYTOCHROME B6-F
COMPLEX SUBUNIT 4
CYTOCHROME B6-F
COMPLEX SUBUNIT 5

(Nostoc sp. PCC
7120;
Nostoc sp. PCC
7120) 		PF00032
(Cytochrom_B_C)
PF02529
(PetG) 		3 GLY B  23
PRO B   7
LEU G  35
 None
 0.61A 3hcpB-2zt9B:
undetectable		 3hcpB-2zt9B:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		3 GLY A 127
PRO A 131
LEU A 345
 GOL  A 424 (-4.2A)
GOL  A 424 ( 4.8A)
None
 0.12A 3hcpB-3aqiA:
60.5		 3hcpB-3aqiA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1

(Mycobacterium
tuberculosis) 		PF00296
(Bac_luciferase) 		3 GLY A 108
PRO A  77
LEU A 132
 F42  A 338 (-3.7A)
None
None
 0.60A 3hcpB-3b4yA:
undetectable		 3hcpB-3b4yA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b64 MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN

(Leishmania
major) 		PF01187
(MIF) 		3 GLY A  67
PRO A   1
LEU A  31
 None
 0.57A 3hcpB-3b64A:
undetectable		 3hcpB-3b64A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 GLY A 137
PRO A 169
LEU A 139
 None
 0.63A 3hcpB-3ckzA:
undetectable		 3hcpB-3ckzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLY A 304
PRO A 301
LEU A 312
 None
 0.47A 3hcpB-3d46A:
undetectable		 3hcpB-3d46A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfa CALCIUM-DEPENDENT
PROTEIN KINASE
CGD3_920

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 GLY A 220
PRO A 204
LEU A 244
 None
 0.55A 3hcpB-3dfaA:
undetectable		 3hcpB-3dfaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgz THIOREDOXIN
REDUCTASE 2

(Mus musculus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLY A 172
PRO A  42
LEU A 169
 None
 0.63A 3hcpB-3dgzA:
undetectable		 3hcpB-3dgzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 GLY A 599
PRO A 593
LEU A 705
 None
 0.57A 3hcpB-3dwbA:
undetectable		 3hcpB-3dwbA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		3 GLY A 237
PRO A 221
LEU A 261
 None
 0.49A 3hcpB-3dxnA:
undetectable		 3hcpB-3dxnA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		3 GLY A 165
PRO A 139
LEU A   8
 None
 0.62A 3hcpB-3e96A:
undetectable		 3hcpB-3e96A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLY A 295
PRO A 292
LEU A 303
 None
 0.44A 3hcpB-3ekgA:
undetectable		 3hcpB-3ekgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 GLY A 239
PRO A 223
LEU A 263
 None
 0.49A 3hcpB-3f3zA:
undetectable		 3hcpB-3f3zA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		3 GLY A 190
PRO A  54
LEU A 197
 None
 0.49A 3hcpB-3gwfA:
undetectable		 3hcpB-3gwfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 GLY A 246
PRO A  27
LEU A 211
 None
 0.44A 3hcpB-3h55A:
2.8		 3hcpB-3h55A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLY A 405
PRO A 408
LEU A 400
 None
 0.60A 3hcpB-3hdiA:
undetectable		 3hcpB-3hdiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLY A  99
PRO A 269
LEU A 275
 None
 0.61A 3hcpB-3hpfA:
3.1		 3hcpB-3hpfA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 GLY A 290
PRO A 274
LEU A 314
 None
 0.48A 3hcpB-3hztA:
undetectable		 3hcpB-3hztA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7d SUGAR PHOSPHATE
ISOMERASE

(Ruegeria
pomeroyi) 		PF07883
(Cupin_2) 		3 GLY A 158
PRO A  18
LEU A 152
 None
 0.57A 3hcpB-3i7dA:
undetectable		 3hcpB-3i7dA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 GLY A 289
PRO A 273
LEU A 313
 None
 0.57A 3hcpB-3igoA:
undetectable		 3hcpB-3igoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir8 LARGE STOKES SHIFT
FLUORESCENT PROTEIN

(Montipora sp.
20) 		PF01353
(GFP) 		3 GLY A 151
PRO A 186
LEU A 153
 None
 0.63A 3hcpB-3ir8A:
undetectable		 3hcpB-3ir8A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 GLY A 275
PRO A 259
LEU A 299
 None
 0.52A 3hcpB-3lijA:
undetectable		 3hcpB-3lijA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		3 GLY X  89
PRO X  85
LEU X 120
 None
 0.62A 3hcpB-3lxuX:
2.6		 3hcpB-3lxuX:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 GLY B 295
PRO B 345
LEU B 299
 None
 0.62A 3hcpB-3m2rB:
undetectable		 3hcpB-3m2rB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		3 GLY A  70
PRO A  92
LEU A  72
 None
 0.56A 3hcpB-3m4xA:
undetectable		 3hcpB-3m4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7a UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF02643
(DUF192) 		3 GLY A 139
PRO A  95
LEU A 116
 None
 0.57A 3hcpB-3m7aA:
undetectable		 3hcpB-3m7aA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		3 GLY A 248
PRO A 232
LEU A 272
 None
 0.53A 3hcpB-3ma6A:
undetectable		 3hcpB-3ma6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLY A 161
PRO A 164
LEU A 185
 None
 0.54A 3hcpB-3oneA:
4.4		 3hcpB-3oneA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		3 GLY A  98
PRO A 152
LEU A 124
 None
 0.51A 3hcpB-3ot5A:
3.7		 3hcpB-3ot5A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 3 GLY A 288
PRO A 299
LEU A 366
 None
 0.63A 3hcpB-3picA:
undetectable		 3hcpB-3picA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Coccidioides
immitis) 		PF01116
(F_bP_aldolase) 		3 GLY A 189
PRO A 186
LEU A 207
 None
 0.56A 3hcpB-3pm6A:
undetectable		 3hcpB-3pm6A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 GLY A 281
PRO A 265
LEU A 305
 None
 0.46A 3hcpB-3q5iA:
undetectable		 3hcpB-3q5iA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rez PLATELET
GLYCOPROTEIN IB BETA
CHAIN, PLATELET
GLYCOPROTEIN IX

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT) 		3 GLY A  15
PRO A   4
LEU A  19
 None
 0.60A 3hcpB-3rezA:
undetectable		 3hcpB-3rezA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 GLY A  79
PRO A 431
LEU A  33
 None
 0.63A 3hcpB-3rj8A:
undetectable		 3hcpB-3rj8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		3 GLY A 268
PRO A 271
LEU A 392
 None
 0.57A 3hcpB-3sdoA:
undetectable		 3hcpB-3sdoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se5 CELL FILAMENTATION
PROTEIN FIC-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF02661
(Fic) 		3 GLY A  58
PRO A 108
LEU A  42
 None
 0.54A 3hcpB-3se5A:
undetectable		 3hcpB-3se5A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chlorella
variabilis) 		PF00692
(dUTPase) 		3 GLY A  28
PRO A  19
LEU A  31
 None
 0.61A 3hcpB-3so2A:
undetectable		 3hcpB-3so2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 GLY A 265
PRO A 249
LEU A 289
 None
 0.46A 3hcpB-3sxfA:
undetectable		 3hcpB-3sxfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0n MRUBY

(Entacmaea
quadricolor) 		PF01353
(GFP) 		3 GLY A 152
PRO A 190
LEU A 154
 None
 0.58A 3hcpB-3u0nA:
undetectable		 3hcpB-3u0nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u15 PROTEIN MDM4

(Homo sapiens) 		PF02201
(SWIB) 		3 GLY A  44
PRO A  29
LEU A  37
 None
 0.62A 3hcpB-3u15A:
undetectable		 3hcpB-3u15A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 GLY A  37
PRO A  40
LEU A 114
 None
 0.59A 3hcpB-3uj2A:
undetectable		 3hcpB-3uj2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6j SCPB

(Geobacillus
stearothermophilus) 		PF04079
(SMC_ScpB) 		3 GLY B  96
PRO B  99
LEU B  91
 None
 0.53A 3hcpB-3w6jB:
undetectable		 3hcpB-3w6jB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae7 THIOESTERASE
SUPERFAMILY MEMBER 5

(Homo sapiens) 		PF03061
(4HBT) 		3 GLY A 159
PRO A 153
LEU A 193
 None
 0.45A 3hcpB-4ae7A:
undetectable		 3hcpB-4ae7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		3 GLY A 499
PRO A 462
LEU A 536
 None
 0.63A 3hcpB-4am3A:
undetectable		 3hcpB-4am3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		3 GLY A 524
PRO A 521
LEU A 448
 None
 0.58A 3hcpB-4ap3A:
2.7		 3hcpB-4ap3A:
20.07