SIMILAR PATTERNS OF AMINO ACIDS FOR 3HCO_B_CHDB1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aut ACTIVATED PROTEIN C

(Homo sapiens) 		PF00008
(EGF)
PF14670
(FXa_inhibition) 		4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
 None
 1.31A 3hcoB-1autL:
undetectable		 3hcoB-1autL:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		4 LEU A  93
PRO A 127
LEU A 157
ARG A 164
 None
 1.32A 3hcoB-1d2rA:
2.0		 3hcoB-1d2rA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 LEU A 426
PRO A 425
LEU A 567
ARG A 569
 None
 1.39A 3hcoB-1dgsA:
undetectable		 3hcoB-1dgsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		4 LEU A 104
PRO A 120
LEU A  58
ARG A  60
 None
FAD  A 600 ( 4.5A)
None
None
 1.37A 3hcoB-1f0xA:
undetectable		 3hcoB-1f0xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 LEU A 282
PRO A 283
LEU A 285
ARG A 253
 None
 1.22A 3hcoB-1hl2A:
2.2		 3hcoB-1hl2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk2 SMAD 3

(Homo sapiens) 		PF03166
(MH2) 		4 LEU A 403
PRO A 402
LEU A 406
ARG A 367
 None
None
None
ACY  A   1 (-3.6A)
 1.34A 3hcoB-1mk2A:
undetectable		 3hcoB-1mk2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A1300
PRO A1301
LEU A1302
ARG A1311
 None
 1.25A 3hcoB-1p0cA:
3.3		 3hcoB-1p0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6m RIBONUCLEASE PH

(Pseudomonas
aeruginosa) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A 108
PRO A 155
LEU A 151
ARG A 148
 None
 1.32A 3hcoB-1r6mA:
undetectable		 3hcoB-1r6mA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 LEU A  70
PRO A  71
LEU A  77
ARG A 182
 None
 1.09A 3hcoB-1rj6A:
undetectable		 3hcoB-1rj6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)

(Gallus gallus) 		PF12796
(Ank_2) 		4 LEU B 143
PRO B 142
LEU B 155
ARG B 161
 None
 1.25A 3hcoB-1s70B:
undetectable		 3hcoB-1s70B:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU A 151
PRO A 196
LEU A 414
ARG A 411
 None
 1.37A 3hcoB-1ufaA:
undetectable		 3hcoB-1ufaA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		4 LEU A 295
PRO A 296
LEU A 294
ARG A 338
 None
 1.34A 3hcoB-1ujnA:
1.9		 3hcoB-1ujnA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd5 HYPOTHETICAL PROTEIN
TT1426

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		4 LEU A 175
PRO A 156
LEU A  13
ARG A  44
 None
None
None
MES  A2955 ( 3.9A)
 1.31A 3hcoB-1wd5A:
undetectable		 3hcoB-1wd5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 LEU A  96
PRO A 133
LEU A 127
ARG A 150
 None
 1.24A 3hcoB-1wf3A:
3.7		 3hcoB-1wf3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 LEU A  87
PRO A 206
LEU A  49
ARG A  52
 None
 1.29A 3hcoB-1xt8A:
undetectable		 3hcoB-1xt8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE

(Bos taurus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A 115
PRO A 118
LEU A 120
ARG A 123
 None
 1.31A 3hcoB-1zyeA:
2.2		 3hcoB-1zyeA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 LEU A 305
PRO A 306
LEU A 349
ARG A 355
 None
 1.32A 3hcoB-2b9bA:
undetectable		 3hcoB-2b9bA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2duy COMPETENCE PROTEIN
COMEA-RELATED
PROTEIN

(Thermus
thermophilus) 		PF12836
(HHH_3) 		4 LEU A  66
PRO A  63
LEU A  56
ARG A  51
 None
 1.17A 3hcoB-2duyA:
undetectable		 3hcoB-2duyA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8g HYPOTHETICAL PROTEIN
PH0536

(Pyrococcus
horikoshii) 		PF01588
(tRNA_bind) 		4 LEU A 124
PRO A  59
LEU A  62
ARG A  53
 None
 1.25A 3hcoB-2e8gA:
undetectable		 3hcoB-2e8gA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		4 LEU C 252
PRO C 251
LEU C  98
ARG C 100
 None
 1.18A 3hcoB-2fm8C:
undetectable		 3hcoB-2fm8C:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fus FUMARASE C

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LEU A  91
PRO A  90
LEU A  30
ARG A  28
 None
 1.16A 3hcoB-2fusA:
undetectable		 3hcoB-2fusA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		4 LEU A 601
PRO A 512
LEU A 565
ARG A 561
 None
 1.34A 3hcoB-2hruA:
2.7		 3hcoB-2hruA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		4 LEU A 500
PRO A 501
LEU A 522
ARG A 523
 None
 1.37A 3hcoB-2ktqA:
undetectable		 3hcoB-2ktqA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljr GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  54
PRO A  55
LEU A   7
ARG A  31
 None
 1.20A 3hcoB-2ljrA:
undetectable		 3hcoB-2ljrA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00581
(Rhodanese) 		4 LEU A 155
PRO A 152
LEU A 269
ARG A 178
 None
 1.24A 3hcoB-2oucA:
undetectable		 3hcoB-2oucA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A1522
PRO A1521
LEU A1564
ARG A1566
 None
 1.36A 3hcoB-2pffA:
2.4		 3hcoB-2pffA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1c RIBOSOME-BINDING
FACTOR A

(Thermus
thermophilus) 		PF02033
(RBFA) 		4 LEU A  82
PRO A  83
LEU A  73
ARG A  76
 None
 1.04A 3hcoB-2r1cA:
undetectable		 3hcoB-2r1cA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6i UNCHARACTERIZED
PROTEIN ATU1473

(Agrobacterium
fabrum) 		PF07542
(ATP12) 		4 LEU A   8
PRO A  28
LEU A   5
ARG A  95
 None
 1.28A 3hcoB-2r6iA:
undetectable		 3hcoB-2r6iA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU B 291
PRO B 295
LEU B 307
ARG B 287
 None
 1.32A 3hcoB-2v9tB:
undetectable		 3hcoB-2v9tB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 LEU A 613
PRO A 423
LEU A 610
ARG A 609
 None
 1.22A 3hcoB-2wkpA:
4.0		 3hcoB-2wkpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE

(Synechococcus
sp. WH 8020) 		PF05996
(Fe_bilin_red) 		4 LEU A  21
PRO A  22
LEU A  43
ARG A  50
 None
 1.25A 3hcoB-2x9oA:
undetectable		 3hcoB-2x9oA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xci 3-DEOXY-D-MANNO-2-OC
TULOSONIC ACID
TRANSFERASE

(Aquifex
aeolicus) 		PF04413
(Glycos_transf_N) 		4 LEU A 209
PRO A 211
LEU A 243
ARG A 225
 None
 1.29A 3hcoB-2xciA:
3.2		 3hcoB-2xciA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 LEU A 375
PRO A 376
LEU A 379
ARG A 550
 None
 1.12A 3hcoB-2xydA:
undetectable		 3hcoB-2xydA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 LEU A 112
PRO A 111
LEU A 183
ARG A 157
 None
 1.40A 3hcoB-2ywbA:
2.7		 3hcoB-2ywbA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		4 LEU A 212
PRO A 213
LEU A 238
ARG A 190
 None
 1.22A 3hcoB-2zoaA:
2.2		 3hcoB-2zoaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyz PUTATIVE
UNCHARACTERIZED
PROTEIN PAE0789
TRNA-SPLICING
ENDONUCLEASE

(Pyrobaculum
aerophilum;
Pyrobaculum
aerophilum) 		no annotation
PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		4 LEU A  87
PRO A  88
LEU B 103
ARG B 101
 None
 1.25A 3hcoB-2zyzA:
undetectable		 3hcoB-2zyzA:
16.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		4 LEU A 101
PRO A 102
LEU A 107
ARG A 114
 CHD  A   3 ( 4.9A)
CHD  A   3 ( 4.7A)
CHD  A   3 ( 4.6A)
CHD  A   2 (-3.6A)
 0.49A 3hcoB-3aqiA:
54.4		 3hcoB-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5m UNCHARACTERIZED
PROTEIN

(Rhodopirellula
baltica) 		PF04289
(DUF447) 		4 LEU A  39
PRO A  41
LEU A 118
ARG A 105
 None
 1.01A 3hcoB-3b5mA:
undetectable		 3hcoB-3b5mA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 LEU A  75
PRO A  76
LEU A  78
ARG A  70
 None
 1.34A 3hcoB-3bgwA:
2.6		 3hcoB-3bgwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chm COP9 SIGNALOSOME
COMPLEX SUBUNIT 7

(Arabidopsis
thaliana) 		PF01399
(PCI) 		4 LEU A  84
PRO A  85
LEU A  65
ARG A  67
 None
 1.29A 3hcoB-3chmA:
undetectable		 3hcoB-3chmA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cio TYROSINE-PROTEIN
KINASE ETK

(Escherichia
coli) 		PF13614
(AAA_31) 		4 LEU A 570
PRO A 618
LEU A 624
ARG A 629
 None
 1.25A 3hcoB-3cioA:
3.8		 3hcoB-3cioA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqh L-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE ULAE

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		4 LEU A  15
PRO A  16
LEU A  27
ARG A 268
 None
 1.21A 3hcoB-3cqhA:
undetectable		 3hcoB-3cqhA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C LIGHT
CHAIN

(Homo sapiens) 		PF00008
(EGF)
PF14670
(FXa_inhibition) 		4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
 None
 1.27A 3hcoB-3f6uL:
undetectable		 3hcoB-3f6uL:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		4 LEU A 381
PRO A 432
LEU A 436
ARG A 438
 None
 1.24A 3hcoB-3fcrA:
undetectable		 3hcoB-3fcrA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.34A 3hcoB-3fd2A:
undetectable		 3hcoB-3fd2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvz UNCHARACTERIZED
PROTEIN CV2077

(Chromobacterium
violaceum) 		PF03417
(AAT) 		4 LEU A  99
PRO A 100
LEU A 103
ARG A 160
 None
 1.06A 3hcoB-3gvzA:
undetectable		 3hcoB-3gvzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		4 LEU A 237
PRO A 238
LEU A 212
ARG A 272
 None
 1.23A 3hcoB-3gxoA:
2.8		 3hcoB-3gxoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 824
PRO A 825
LEU A 846
ARG A 852
 None
 1.28A 3hcoB-3hmjA:
2.0		 3hcoB-3hmjA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 LEU A  42
PRO A  43
LEU A  47
ARG A  24
 None
 0.73A 3hcoB-3i2tA:
undetectable		 3hcoB-3i2tA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyz SENSOR PROTEIN PFES

(Pseudomonas
aeruginosa) 		PF16750
(HK_sensor) 		4 LEU A 142
PRO A 143
LEU A 146
ARG A  44
 None
 1.39A 3hcoB-3kyzA:
undetectable		 3hcoB-3kyzA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		4 LEU A  53
PRO A  52
LEU A 384
ARG A 351
 None
 1.29A 3hcoB-3l4dA:
undetectable		 3hcoB-3l4dA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Sinorhizobium
meliloti) 		PF01557
(FAA_hydrolase) 		4 LEU A  75
PRO A  74
LEU A  35
ARG A 163
 None
 1.22A 3hcoB-3lzkA:
undetectable		 3hcoB-3lzkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mip MSO-8G

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.35A 3hcoB-3mipA:
undetectable		 3hcoB-3mipA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 336
PRO A 335
LEU A 325
ARG A 324
 None
 1.22A 3hcoB-3nuuA:
undetectable		 3hcoB-3nuuA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0p SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 LEU A 143
PRO A 144
LEU A 102
ARG A 100
 None
 1.02A 3hcoB-3o0pA:
undetectable		 3hcoB-3o0pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		4 LEU A 134
PRO A 135
LEU A 136
ARG A  99
 None
 1.13A 3hcoB-3o31A:
3.5		 3hcoB-3o31A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 LEU A  61
PRO A  62
LEU A  48
ARG A 231
 None
 1.21A 3hcoB-3p2mA:
3.5		 3hcoB-3p2mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Mycobacteroides
abscessus) 		PF01259
(SAICAR_synt) 		4 LEU A 125
PRO A 126
LEU A 129
ARG A 134
 LEU  A 125 ( 0.6A)
PRO  A 126 ( 1.1A)
LEU  A 129 ( 0.6A)
ARG  A 134 ( 0.6A)
 1.18A 3hcoB-3r9rA:
undetectable		 3hcoB-3r9rA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 147
PRO A 176
LEU A  94
ARG A  96
 None
 1.35A 3hcoB-3ri6A:
undetectable		 3hcoB-3ri6A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF16823
(PilZ_2) 		4 LEU A 136
PRO A 128
LEU A  45
ARG A  47
 None
 1.35A 3hcoB-3rqaA:
undetectable		 3hcoB-3rqaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 LEU A 277
PRO A 279
LEU A 303
ARG A 297
 None
 1.19A 3hcoB-3s2uA:
4.4		 3hcoB-3s2uA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 LEU A  77
PRO A  78
LEU A  22
ARG A  20
 None
 1.22A 3hcoB-3szbA:
undetectable		 3hcoB-3szbA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg1 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00581
(Rhodanese) 		4 LEU B 155
PRO B 152
LEU B 269
ARG B 178
 None
 1.26A 3hcoB-3tg1B:
2.4		 3hcoB-3tg1B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		4 LEU A 403
PRO A 404
LEU A 389
ARG A 453
 None
 1.17A 3hcoB-3tp9A:
3.0		 3hcoB-3tp9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II

(Burkholderia
pseudomallei) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LEU A 231
PRO A 230
LEU A 170
ARG A 168
 None
 1.20A 3hcoB-3tv2A:
undetectable		 3hcoB-3tv2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		4 LEU A 317
PRO A 316
LEU A 320
ARG A 342
 None
 1.40A 3hcoB-4d3yA:
undetectable		 3hcoB-4d3yA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 LEU A  33
PRO A  28
LEU A  45
ARG A  43
 None
 1.24A 3hcoB-4ddwA:
undetectable		 3hcoB-4ddwA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		4 LEU A 191
PRO A 190
LEU A 179
ARG A  77
 None
 1.25A 3hcoB-4e4jA:
undetectable		 3hcoB-4e4jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frw POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 4

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 LEU A  50
PRO A  51
LEU A 141
ARG A 142
 None
 1.29A 3hcoB-4frwA:
undetectable		 3hcoB-4frwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB

(Acinetobacter
baumannii) 		PF01636
(APH) 		4 LEU A  81
PRO A  82
LEU A  72
ARG A  71
 None
0J9  A 302 (-4.5A)
None
None
 1.20A 3hcoB-4gkhA:
undetectable		 3hcoB-4gkhA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgv FUMARATE HYDRATASE
CLASS II

(Sinorhizobium
meliloti) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LEU A 101
PRO A 100
LEU A  40
ARG A  38
 None
 1.12A 3hcoB-4hgvA:
undetectable		 3hcoB-4hgvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxc FEFE-HYDROGENASE
MATURASE

(Thermotoga
maritima) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 LEU A 238
PRO A 237
LEU A  68
ARG A 172
 None
 1.33A 3hcoB-4jxcA:
undetectable		 3hcoB-4jxcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mda MARINER MOS1
TRANSPOSASE

(Drosophila
mauritiana) 		PF01359
(Transposase_1) 		4 LEU A 329
PRO A 330
LEU A 149
ARG A 151
 None
 1.36A 3hcoB-4mdaA:
undetectable		 3hcoB-4mdaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE

(Geobacillus
stearothermophilus) 		PF16499
(Melibiase_2) 		4 LEU A 288
PRO A 289
LEU A 290
ARG A 315
 None
 1.35A 3hcoB-4nxkA:
undetectable		 3hcoB-4nxkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oib INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		4 LEU A  97
PRO A  98
LEU A 190
ARG A 128
 None
 0.66A 3hcoB-4oibA:
undetectable		 3hcoB-4oibA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2

(Danio rerio) 		PF00067
(p450) 		4 LEU A  70
PRO A  69
LEU A  88
ARG A  96
 None
 1.17A 3hcoB-4r20A:
undetectable		 3hcoB-4r20A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7b MARINER MOS1
TRANSPOSASE

(Drosophila
mauritiana) 		PF01359
(Transposase_1) 		4 LEU A 329
PRO A 330
LEU A 149
ARG A 151
 None
 1.35A 3hcoB-4u7bA:
undetectable		 3hcoB-4u7bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uur PUTATIVE
HEMOGLOBIN-LIKE
OXYGEN-BINDING
PROTEIN

(Pseudoalteromonas
haloplanktis) 		PF01152
(Bac_globin) 		4 LEU A  54
PRO A  53
LEU A 105
ARG A 106
 HEM  A 700 (-4.7A)
None
HEM  A 700 ( 4.3A)
None
 1.22A 3hcoB-4uurA:
undetectable		 3hcoB-4uurA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.26A 3hcoB-4zasA:
undetectable		 3hcoB-4zasA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 LEU A 362
PRO A 364
LEU A 306
ARG A 325
 None
 1.32A 3hcoB-4zdkA:
3.3		 3hcoB-4zdkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 199
PRO A 200
LEU A 204
ARG A 211
 None
 1.05A 3hcoB-4zwvA:
2.0		 3hcoB-4zwvA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b01 MOEN5

(Streptomyces
viridosporus) 		no annotation 4 LEU A  59
PRO A  39
LEU A  42
ARG A 171
 None
 1.19A 3hcoB-5b01A:
undetectable		 3hcoB-5b01A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0l MOEN5,DNA-BINDING
PROTEIN 7D

(Sulfolobus
solfataricus;
Streptomyces
viridosporus) 		no annotation 4 LEU A  59
PRO A  39
LEU A  42
ARG A 171
 None
 1.24A 3hcoB-5b0lA:
undetectable		 3hcoB-5b0lA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		4 LEU A 264
PRO A 265
LEU A 392
ARG A 331
 None
 1.28A 3hcoB-5b4wA:
undetectable		 3hcoB-5b4wA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw0 TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa) 		PF11612
(T2SSJ) 		4 LEU A 177
PRO A 178
LEU A 199
ARG A  94
 None
None
None
SO4  A 302 (-3.4A)
 1.28A 3hcoB-5bw0A:
undetectable		 3hcoB-5bw0A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 LEU A 808
PRO A 807
LEU A 626
ARG A 624
 None
 1.12A 3hcoB-5ezrA:
undetectable		 3hcoB-5ezrA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		4 LEU A1236
PRO A1237
LEU A1262
ARG A1268
 None
 1.04A 3hcoB-5fv0A:
2.5		 3hcoB-5fv0A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 LEU A 888
PRO A 885
LEU A 809
ARG A 811
 None
 1.20A 3hcoB-5i4eA:
undetectable		 3hcoB-5i4eA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE

(Bacillus
anthracis) 		PF04127
(DFP) 		4 LEU A 376
PRO A 377
LEU A 379
ARG A 386
 None
 0.70A 3hcoB-5intA:
3.9		 3hcoB-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktz VP1

(Enterovirus C) 		PF00073
(Rhv) 		4 LEU 1 261
PRO 1 263
LEU 1 118
ARG 1 119
 None
 1.36A 3hcoB-5ktz1:
undetectable		 3hcoB-5ktz1:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n03 GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT B

(Myxococcus
xanthus) 		no annotation 4 LEU D  35
PRO D  34
LEU D 243
ARG D 151
 None
 1.34A 3hcoB-5n03D:
undetectable		 3hcoB-5n03D:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 LEU A 553
PRO A 549
LEU A 627
ARG A 643
 None
 1.19A 3hcoB-5opqA:
undetectable		 3hcoB-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE

(Azospirillum
brasilense) 		no annotation 4 LEU A 287
PRO A 134
LEU A 137
ARG A   7
 None
 1.36A 3hcoB-5ovoA:
undetectable		 3hcoB-5ovoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3t FUSION PROTEIN OF
NUCLEOPROTEIN AND
MINOR NUCLEOPROTEIN
VP30

(Zaire
ebolavirus) 		PF05505
(Ebola_NP)
PF11507
(Transcript_VP30) 		4 LEU A 249
PRO A 250
LEU A 188
ARG A 195
 None
 0.88A 3hcoB-5t3tA:
undetectable		 3hcoB-5t3tA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 LEU A 251
PRO A 252
LEU A 140
ARG A  64
 None
 1.21A 3hcoB-5t65A:
undetectable		 3hcoB-5t65A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 4 LEU A  86
PRO A  85
LEU A 536
ARG A 538
 None
 0.93A 3hcoB-5u2oA:
undetectable		 3hcoB-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vao MINOR NUCLEOPROTEIN
VP30

(Zaire
ebolavirus) 		PF11507
(Transcript_VP30) 		4 LEU A 249
PRO A 250
LEU A 188
ARG A 195
 None
 1.35A 3hcoB-5vaoA:
undetectable		 3hcoB-5vaoA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 LEU A1370
PRO A1373
LEU A1400
ARG A1240
 None
 1.20A 3hcoB-5w81A:
undetectable		 3hcoB-5w81A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE

(Bacillus
licheniformis) 		no annotation 4 LEU A 345
PRO A 344
LEU A 348
ARG A 331
 LEU  A 345 ( 0.5A)
PRO  A 344 ( 1.1A)
LEU  A 348 ( 0.5A)
ARG  A 331 ( 0.6A)
 1.39A 3hcoB-5xluA:
undetectable		 3hcoB-5xluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 LEU B 497
PRO B 496
LEU B 500
ARG B 201
 None
 1.32A 3hcoB-6f0kB:
undetectable		 3hcoB-6f0kB:
undetectable