SIMILAR PATTERNS OF AMINO ACIDS FOR 3HCN_B_CHDB2_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0p SITE-SPECIFIC
RECOMBINASE XERD

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		3 LEU A 142
LEU A 139
ARG A 134
 None
 0.67A 3hcnB-1a0pA:
undetectable		 3hcnB-1a0pA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8q BROMOPEROXIDASE A1

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		3 LEU A  80
LEU A  85
ARG A  20
 None
 0.75A 3hcnB-1a8qA:
3.4		 3hcnB-1a8qA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		3 LEU A 426
LEU A 579
ARG A 585
 None
 0.76A 3hcnB-1b25A:
undetectable		 3hcnB-1b25A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		3 LEU A 246
LEU A 224
ARG A 221
 None
None
HEM  A 400 (-4.4A)
 0.60A 3hcnB-1bgpA:
undetectable		 3hcnB-1bgpA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bi7 MULTIPLE TUMOR
SUPPRESSOR

(Homo sapiens) 		no annotation 3 LEU B  97
LEU B  94
ARG B  87
 None
 0.75A 3hcnB-1bi7B:
undetectable		 3hcnB-1bi7B:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)

(Escherichia
coli) 		PF03852
(Vsr) 		3 LEU A 107
LEU A 104
ARG A  99
 None
 0.71A 3hcnB-1cw0A:
undetectable		 3hcnB-1cw0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 LEU A 328
LEU A 331
ARG A 387
 None
 0.54A 3hcnB-1d2fA:
3.4		 3hcnB-1d2fA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE

(Bemisia
argentifolii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LEU A 325
LEU A   6
ARG A  21
 None
 0.69A 3hcnB-1e3jA:
undetectable		 3hcnB-1e3jA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 LEU A  37
LEU A  53
ARG A  18
 None
 0.63A 3hcnB-1i7qA:
undetectable		 3hcnB-1i7qA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		3 LEU A 545
LEU A 553
ARG A 501
 None
 0.74A 3hcnB-1j2bA:
undetectable		 3hcnB-1j2bA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		3 LEU A 214
LEU A 217
ARG A 176
 None
 0.67A 3hcnB-1jqkA:
3.7		 3hcnB-1jqkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		3 LEU A 170
LEU A   3
ARG A   5
 None
 0.75A 3hcnB-1ka0A:
undetectable		 3hcnB-1ka0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LEU A 164
LEU A 167
ARG A 345
 None
 0.73A 3hcnB-1kolA:
2.7		 3hcnB-1kolA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09105
(SelB-wing_1)
PF09106
(SelB-wing_2)
PF09107
(SelB-wing_3) 		3 LEU A 464
LEU A 451
ARG A 449
 None
 0.74A 3hcnB-1lvaA:
undetectable		 3hcnB-1lvaA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdy PROTEIN (MYOD BHLH
DOMAIN)

(Mus musculus) 		PF00010
(HLH) 		3 LEU B 163
LEU B 160
ARG B 155
 None
 0.76A 3hcnB-1mdyB:
undetectable		 3hcnB-1mdyB:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mfa IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)

(Mus musculus) 		PF07686
(V-set) 		3 LEU L  20
LEU L  75
ARG L  63
 None
 0.72A 3hcnB-1mfaL:
undetectable		 3hcnB-1mfaL:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfp LUXF GENE PRODUCT

(Photobacterium
leiognathi) 		PF00296
(Bac_luciferase) 		3 LEU A  75
LEU A  93
ARG A 103
 None
 0.75A 3hcnB-1nfpA:
undetectable		 3hcnB-1nfpA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ

(Escherichia
coli) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		3 LEU A  16
LEU A 105
ARG A 103
 None
 0.76A 3hcnB-1ni5A:
2.5		 3hcnB-1ni5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyt SHIKIMATE
5-DEHYDROGENASE

(Escherichia
coli) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 LEU A 139
LEU A 136
ARG A 132
 None
 0.66A 3hcnB-1nytA:
3.8		 3hcnB-1nytA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		3 LEU A 114
LEU A 150
ARG A 168
 None
 0.64A 3hcnB-1o12A:
undetectable		 3hcnB-1o12A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		3 LEU A 318
LEU A 268
ARG A 394
 None
None
SGC  A 902 ( 3.5A)
 0.69A 3hcnB-1q2eA:
undetectable		 3hcnB-1q2eA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry6 INTERNAL KINESIN

(Plasmodium
falciparum) 		PF00225
(Kinesin) 		3 LEU A 229
LEU A 220
ARG A 180
 None
 0.57A 3hcnB-1ry6A:
undetectable		 3hcnB-1ry6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv6 2-KETO-4-PENTENOATE
HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 LEU A  29
LEU A  26
ARG A 145
 None
 0.63A 3hcnB-1sv6A:
undetectable		 3hcnB-1sv6A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		3 LEU A 232
LEU A 215
ARG A 217
 None
 0.59A 3hcnB-1t8qA:
2.4		 3hcnB-1t8qA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp6 HYPOTHETICAL PROTEIN
PA1314

(Pseudomonas
aeruginosa) 		PF14534
(DUF4440) 		3 LEU A  55
LEU A  58
ARG A  66
 None
 0.71A 3hcnB-1tp6A:
undetectable		 3hcnB-1tp6A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u84 HYPOTHETICAL PROTEIN

(Geobacillus
stearothermophilus) 		PF08958
(DUF1871) 		3 LEU A  78
LEU A  10
ARG A   8
 None
 0.72A 3hcnB-1u84A:
undetectable		 3hcnB-1u84A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 3 LEU A  26
LEU A 107
ARG A 101
 None
 0.74A 3hcnB-1ufoA:
3.1		 3hcnB-1ufoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		3 LEU A1739
LEU A1742
ARG A1717
 None
 0.66A 3hcnB-1uyvA:
undetectable		 3hcnB-1uyvA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkr MANNITOL-SPECIFIC
PTS SYSTEM ENZYME
IIABC COMPONENTS

(Escherichia
coli) 		PF02302
(PTS_IIB) 		3 LEU A 449
LEU A 457
ARG A 464
 None
 0.68A 3hcnB-1vkrA:
4.1		 3hcnB-1vkrA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrv MANNITOL-SPECIFIC
PTS SYSTEM ENZYME
IIABC COMPONENTS

(Escherichia
coli) 		PF02302
(PTS_IIB) 		3 LEU A 449
LEU A 457
ARG A 464
 None
 0.69A 3hcnB-1vrvA:
4.5		 3hcnB-1vrvA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		3 LEU C  95
LEU C  98
ARG C 105
 None
 0.64A 3hcnB-1w36C:
2.4		 3hcnB-1w36C:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1e 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		3 LEU A 185
LEU A 191
ARG A 198
 None
 0.76A 3hcnB-1x1eA:
2.8		 3hcnB-1x1eA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 LEU A  60
LEU A 195
ARG A 260
 None
 0.64A 3hcnB-1xp4A:
undetectable		 3hcnB-1xp4A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsr UREIDOGLYCOLATE
HYDROLASE

(Shigella
flexneri) 		PF04115
(Ureidogly_lyase) 		3 LEU A  47
LEU A  76
ARG A  73
 None
 0.68A 3hcnB-1xsrA:
undetectable		 3hcnB-1xsrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 LEU A 214
LEU A 141
ARG A  18
 None
 0.70A 3hcnB-1yq2A:
undetectable		 3hcnB-1yq2A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB

(Mycobacterium
tuberculosis) 		PF02518
(HATPase_c) 		3 LEU A 365
LEU A 328
ARG A 312
 None
 0.69A 3hcnB-1ysrA:
undetectable		 3hcnB-1ysrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		3 LEU A 342
LEU A 325
ARG A 303
 None
 0.63A 3hcnB-1yt8A:
2.9		 3hcnB-1yt8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpw HYPOTHETICAL PROTEIN
TT1823

(Thermus
thermophilus) 		PF09827
(CRISPR_Cas2) 		3 LEU X  41
LEU X  45
ARG X  52
 None
 0.67A 3hcnB-1zpwX:
undetectable		 3hcnB-1zpwX:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arj YTS 105.18 ANTIGEN
BINDING REGION LIGHT
CHAIN

(Rattus
norvegicus) 		no annotation 3 LEU L  21
LEU L  73
ARG L  61
 None
 0.65A 3hcnB-2arjL:
undetectable		 3hcnB-2arjL:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 LEU A 103
LEU A 100
ARG A  88
 None
 0.39A 3hcnB-2cfzA:
undetectable		 3hcnB-2cfzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3

(Salmonella
enterica) 		PF00669
(Flagellin_N) 		3 LEU A 121
LEU A 124
ARG A 247
 None
 0.65A 3hcnB-2d4xA:
undetectable		 3hcnB-2d4xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 LEU A  49
LEU A  46
ARG A  38
 None
 0.63A 3hcnB-2dq3A:
undetectable		 3hcnB-2dq3A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqi LYSOZYME BINDING IG
KAPPA CHAIN V23-J2
REGION

(Mus musculus) 		PF07686
(V-set) 		3 LEU L  21
LEU L  73
ARG L  61
 None
 0.74A 3hcnB-2dqiL:
undetectable		 3hcnB-2dqiL:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		3 LEU A 213
LEU A 218
ARG A 292
 None
 0.60A 3hcnB-2fvmA:
undetectable		 3hcnB-2fvmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		3 LEU A 294
LEU A 299
ARG A 312
 None
None
COA  A 800 (-2.7A)
 0.55A 3hcnB-2gq3A:
undetectable		 3hcnB-2gq3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		3 LEU A 201
LEU A 267
ARG A 121
 None
 0.76A 3hcnB-2h34A:
undetectable		 3hcnB-2h34A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2itb TRNA-(MS(2)IO(6)A)-H
YDROXYLASE, PUTATIVE

(Pseudomonas
putida) 		PF06175
(MiaE) 		3 LEU A 102
LEU A  99
ARG A  94
 EDO  A 504 (-4.1A)
None
None
 0.68A 3hcnB-2itbA:
undetectable		 3hcnB-2itbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum) 		PF13247
(Fer4_11) 		3 LEU B  19
LEU B 213
ARG B 217
 None
SF4  B1359 (-4.5A)
None
 0.75A 3hcnB-2ivfB:
undetectable		 3hcnB-2ivfB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		3 LEU A  32
LEU A 116
ARG A 118
 None
 0.74A 3hcnB-2iy8A:
3.1		 3hcnB-2iy8A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lx9 FERROUS IRON
TRANSPORT PROTEIN A

(Escherichia
coli) 		PF04023
(FeoA) 		3 LEU A  68
LEU A  65
ARG A  61
 None
 0.71A 3hcnB-2lx9A:
undetectable		 3hcnB-2lx9A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m3a PROTEIN KNL-2

(Caenorhabditis
elegans) 		no annotation 3 LEU A  43
LEU A  20
ARG A  61
 LEU  A  43 ( 0.6A)
LEU  A  20 ( 0.6A)
ARG  A  61 ( 0.6A)
 0.70A 3hcnB-2m3aA:
undetectable		 3hcnB-2m3aA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4

(Homo sapiens) 		PF16367
(RRM_7) 		3 LEU A 113
LEU A  91
ARG A  87
 None
 0.70A 3hcnB-2mkiA:
undetectable		 3hcnB-2mkiA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		3 LEU A 225
LEU A 279
ARG A 281
 None
 0.76A 3hcnB-2nuxA:
undetectable		 3hcnB-2nuxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		3 LEU A 190
LEU A 164
ARG A 147
 None
 0.71A 3hcnB-2o2gA:
4.1		 3hcnB-2o2gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 LEU B 862
LEU B 909
ARG B 911
 None
 0.72A 3hcnB-2o8eB:
undetectable		 3hcnB-2o8eB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p10 MLL9387 PROTEIN

(Mesorhizobium
japonicum) 		PF09370
(PEP_hydrolase) 		3 LEU A  67
LEU A  70
ARG A 138
 None
ACT  A 286 (-3.7A)
None
 0.60A 3hcnB-2p10A:
undetectable		 3hcnB-2p10A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263

(Thermus
thermophilus) 		PF13429
(TPR_15)
PF14559
(TPR_19) 		3 LEU A  42
LEU A  39
ARG A  34
 None
 0.75A 3hcnB-2pl2A:
undetectable		 3hcnB-2pl2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		3 LEU A 316
LEU A 157
ARG A 312
 None
 0.62A 3hcnB-2qzwA:
undetectable		 3hcnB-2qzwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wui TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		3 LEU A 206
LEU A 154
ARG A 200
 None
 0.71A 3hcnB-2wuiA:
undetectable		 3hcnB-2wuiA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvi MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA

(Homo sapiens) 		PF08311
(Mad3_BUB1_I) 		3 LEU A 124
LEU A 102
ARG A 104
 None
 0.74A 3hcnB-2wviA:
undetectable		 3hcnB-2wviA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		3 LEU A 104
LEU A 119
ARG A  73
 None
 0.70A 3hcnB-2xfsA:
undetectable		 3hcnB-2xfsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 LEU A 294
LEU A 223
ARG A 314
 None
 0.67A 3hcnB-2y3sA:
undetectable		 3hcnB-2y3sA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8u CHITIN DEACETYLASE

(Aspergillus
nidulans) 		PF01522
(Polysacc_deac_1) 		3 LEU A 104
LEU A 107
ARG A 118
 None
 0.75A 3hcnB-2y8uA:
undetectable		 3hcnB-2y8uA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygk NURA

(Sulfolobus
solfataricus) 		PF09376
(NurA) 		3 LEU A 177
LEU A 180
ARG A 158
 None
 0.75A 3hcnB-2ygkA:
undetectable		 3hcnB-2ygkA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		3 LEU A  26
LEU A   4
ARG A 109
 None
 0.63A 3hcnB-2yutA:
2.2		 3hcnB-2yutA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 LEU A 224
LEU A 218
ARG A 216
 None
 0.73A 3hcnB-2zufA:
undetectable		 3hcnB-2zufA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		3 LEU A 140
LEU A 119
ARG A 195
 None
 0.76A 3hcnB-2zyjA:
undetectable		 3hcnB-2zyjA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		3 LEU A 108
LEU A 121
ARG A 123
 None
 0.68A 3hcnB-3aeuA:
undetectable		 3hcnB-3aeuA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		3 LEU A  99
LEU A 131
ARG A 125
 None
ACY  A 601 (-3.9A)
None
 0.59A 3hcnB-3aiiA:
2.3		 3hcnB-3aiiA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		3 LEU A 101
LEU A 107
ARG A 114
 CHD  A   3 ( 4.9A)
CHD  A   3 ( 4.6A)
CHD  A   2 (-3.6A)
 0.65A 3hcnB-3aqiA:
54.5		 3hcnB-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		3 LEU A 181
LEU A 230
ARG A 316
 None
 0.59A 3hcnB-3aquA:
undetectable		 3hcnB-3aquA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		3 LEU A 596
LEU A 593
ARG A 567
 None
 0.69A 3hcnB-3bdlA:
undetectable		 3hcnB-3bdlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ced METHIONINE IMPORT
ATP-BINDING PROTEIN
METN 2

(Staphylococcus
aureus) 		PF09383
(NIL) 		3 LEU A 309
LEU A 268
ARG A 331
 None
 0.50A 3hcnB-3cedA:
undetectable		 3hcnB-3cedA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpg UNCHARACTERIZED
PROTEIN

(Bifidobacterium
adolescentis) 		PF01168
(Ala_racemase_N) 		3 LEU A  52
LEU A  33
ARG A  31
 None
 0.70A 3hcnB-3cpgA:
3.0		 3hcnB-3cpgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwv DNA GYRASE, B
SUBUNIT, TRUNCATED

(Myxococcus
xanthus) 		PF00204
(DNA_gyraseB) 		3 LEU A  65
LEU A  55
ARG A 176
 None
 0.65A 3hcnB-3cwvA:
undetectable		 3hcnB-3cwvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n ASPARTATE
CARBAMOYLTRANSFERASE

(Aquifex
aeolicus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LEU B  65
LEU B  39
ARG B  97
 None
None
FLC  B 292 (-2.8A)
 0.63A 3hcnB-3d6nB:
2.3		 3hcnB-3d6nB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2s PROLINE
DEHYDROGENASE

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 LEU A 428
LEU A 417
ARG A  92
 None
 0.74A 3hcnB-3e2sA:
undetectable		 3hcnB-3e2sA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU X  89
LEU X  86
ARG X  81
 None
 0.72A 3hcnB-3e3bX:
undetectable		 3hcnB-3e3bX:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fp9 PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF16450
(Prot_ATP_ID_OB) 		3 LEU A 188
LEU A 192
ARG A 212
 None
 0.61A 3hcnB-3fp9A:
undetectable		 3hcnB-3fp9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		3 LEU A 314
LEU A 160
ARG A 310
 None
 0.64A 3hcnB-3fv3A:
undetectable		 3hcnB-3fv3A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 LEU A 379
LEU A 374
ARG A 340
 None
 0.73A 3hcnB-3fy4A:
3.1		 3hcnB-3fy4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3s GCN5-RELATED
N-ACETYLTRANSFERASE

(Streptococcus
suis) 		PF12746
(GNAT_acetyltran) 		3 LEU A 197
LEU A 199
ARG A 191
 None
 0.72A 3hcnB-3g3sA:
undetectable		 3hcnB-3g3sA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7t ENVELOPE PROTEIN

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		3 LEU A 253
LEU A 237
ARG A 233
 None
 0.53A 3hcnB-3g7tA:
undetectable		 3hcnB-3g7tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 LEU A 227
LEU A  38
ARG A  35
 None
 0.74A 3hcnB-3girA:
undetectable		 3hcnB-3girA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gna V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		3 LEU A 396
LEU A 399
ARG A 402
 None
 0.71A 3hcnB-3gnaA:
undetectable		 3hcnB-3gnaA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3god CAS1

(Pseudomonas
aeruginosa) 		PF01867
(Cas_Cas1) 		3 LEU A 200
LEU A 197
ARG A 192
 None
 0.68A 3hcnB-3godA:
undetectable		 3hcnB-3godA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		3 LEU A 140
LEU A 102
ARG A 104
 None
 0.74A 3hcnB-3gsiA:
undetectable		 3hcnB-3gsiA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		3 LEU A  13
LEU A  10
ARG A 212
 None
 0.68A 3hcnB-3h0lA:
undetectable		 3hcnB-3h0lA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 LEU A  42
LEU A  47
ARG A  24
 None
 0.59A 3hcnB-3i2tA:
undetectable		 3hcnB-3i2tA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		3 LEU A2204
LEU A1900
ARG A1905
 None
 0.67A 3hcnB-3jbzA:
undetectable		 3hcnB-3jbzA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		3 LEU A  68
LEU A  71
ARG A  74
 None
 0.75A 3hcnB-3kn1A:
undetectable		 3hcnB-3kn1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knz PUTATIVE SUGAR
BINDING PROTEIN

(Salmonella
enterica) 		PF01380
(SIS) 		3 LEU A  12
LEU A 173
ARG A 175
 None
 0.64A 3hcnB-3knzA:
4.4		 3hcnB-3knzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knz PUTATIVE SUGAR
BINDING PROTEIN

(Salmonella
enterica) 		PF01380
(SIS) 		3 LEU A 173
LEU A  12
ARG A  16
 None
 0.65A 3hcnB-3knzA:
4.4		 3hcnB-3knzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13185
(GAF_2) 		3 LEU A  57
LEU A  52
ARG A  85
 None
 0.76A 3hcnB-3ksgA:
undetectable		 3hcnB-3ksgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 LEU A 111
LEU A 116
ARG A  26
 None
 0.55A 3hcnB-3la4A:
undetectable		 3hcnB-3la4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7g TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13404
(HTH_AsnC-type) 		3 LEU A 138
LEU A 142
ARG A 151
 None
 0.71A 3hcnB-3m7gA:
undetectable		 3hcnB-3m7gA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		3 LEU A 203
LEU A 191
ARG A 189
 None
 0.72A 3hcnB-3nm1A:
3.3		 3hcnB-3nm1A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		3 LEU A 429
LEU A 426
ARG A 645
 None
 0.64A 3hcnB-3nz4A:
undetectable		 3hcnB-3nz4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o38 SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		3 LEU A  66
LEU A  68
ARG A  38
 None
 0.76A 3hcnB-3o38A:
2.4		 3hcnB-3o38A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3od1 ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Bacillus
halodurans) 		PF13393
(tRNA-synt_His) 		3 LEU A 220
LEU A 217
ARG A 213
 None
 0.60A 3hcnB-3od1A:
undetectable		 3hcnB-3od1A:
23.78