SIMILAR PATTERNS OF AMINO ACIDS FOR 3HCN_A_CHDA3

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 LEU A 418
ARG A 401
SER A 427
GLY A 169
 None
FUM  A 700 (-3.2A)
None
FUM  A 700 ( 3.0A)
 0.98A 3hcnA-1d4eA:
undetectable		 3hcnA-1d4eA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k82 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 LEU A 216
PRO A   4
SER A 208
GLY A 167
 None
 1.12A 3hcnA-1k82A:
undetectable		 3hcnA-1k82A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		4 MET A  15
LEU A  17
PRO A 202
GLY A 205
 None
 1.10A 3hcnA-1ktnA:
undetectable		 3hcnA-1ktnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 LEU A 250
PRO A 136
SER A 137
GLY A 226
 None
 1.11A 3hcnA-1l1lA:
undetectable		 3hcnA-1l1lA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A 304
ARG A 349
SER A 458
GLY A 236
 None
 1.08A 3hcnA-1loxA:
undetectable		 3hcnA-1loxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		4 MET A 281
LEU A 285
GLY A 236
MET A 254
 None
 1.03A 3hcnA-1nrwA:
2.9		 3hcnA-1nrwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Thermotoga
maritima) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 MET A   1
LEU A   5
ARG A  51
GLY A  46
 None
 1.04A 3hcnA-1o4uA:
2.2		 3hcnA-1o4uA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 ARG A 174
PRO A 216
SER A 255
GLY A 219
 None
 1.09A 3hcnA-1uz4A:
undetectable		 3hcnA-1uz4A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 MET A 315
LEU A 319
PRO A 387
GLY A  37
 None
None
None
FMT  A 607 (-4.6A)
 1.04A 3hcnA-1vp4A:
2.0		 3hcnA-1vp4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		4 LEU A 194
ARG A 154
PRO A 142
GLY A 181
 None
None
None
PO4  A1226 (-3.6A)
 0.94A 3hcnA-1w0mA:
2.3		 3hcnA-1w0mA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 MET A 376
LEU A 324
ARG A 386
PRO A 320
 C2E  A 503 ( 4.8A)
None
None
None
 1.11A 3hcnA-1w25A:
3.4		 3hcnA-1w25A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Plasmodium
falciparum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU O 103
PRO O  82
SER O 110
GLY O  10
 None
None
None
NAD  O 401 (-3.5A)
 0.97A 3hcnA-1ywgO:
2.9		 3hcnA-1ywgO:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 LEU A 240
ARG A 231
PRO A 170
GLY A 224
 None
 1.05A 3hcnA-1z3zA:
undetectable		 3hcnA-1z3zA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 MET A 410
LEU A 407
PRO A 422
SER A 415
 None
 1.02A 3hcnA-1zkcA:
undetectable		 3hcnA-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 MET A 410
LEU A 407
SER A 415
GLY A 332
 None
 1.06A 3hcnA-1zkcA:
undetectable		 3hcnA-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 LEU A 185
ARG A 210
PRO A 177
SER A 133
GLY A 241
 NAD  A2001 (-4.4A)
None
NAD  A2001 (-3.9A)
NAD  A2001 ( 4.0A)
None
 1.49A 3hcnA-2ag5A:
2.3		 3hcnA-2ag5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		4 LEU A 339
PRO A  32
SER A  92
GLY A  35
 None
AE4  A1346 (-4.2A)
None
None
 1.03A 3hcnA-2c2nA:
undetectable		 3hcnA-2c2nA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj1 PROTEIN
DISULFIDE-ISOMERASE
A4

(Mus musculus) 		PF00085
(Thioredoxin) 		4 LEU A  83
PRO A 137
SER A 135
GLY A 101
 None
 0.90A 3hcnA-2dj1A:
3.1		 3hcnA-2dj1A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		4 MET A 255
LEU A 143
SER A 423
GLY A  95
 None
 1.12A 3hcnA-2e0wA:
undetectable		 3hcnA-2e0wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 MET A 261
LEU A 301
SER A 398
GLY A 252
 None
None
None
LLP  A 405 ( 3.4A)
 1.10A 3hcnA-2okjA:
4.2		 3hcnA-2okjA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9w MAL S 1 ALLERGENIC
PROTEIN

(Malassezia
sympodialis) 		no annotation 4 LEU A 131
SER A  78
GLY A  89
MET A  87
 None
 1.12A 3hcnA-2p9wA:
undetectable		 3hcnA-2p9wA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfz TBC1 DOMAIN FAMILY
MEMBER 22A

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 MET A 367
LEU A 371
PRO A 328
MET A 427
 None
 0.92A 3hcnA-2qfzA:
undetectable		 3hcnA-2qfzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE

(Vibrio
parahaemolyticus) 		PF00282
(Pyridoxal_deC) 		4 LEU A 738
ARG A 770
SER A 669
GLY A 733
 None
 1.09A 3hcnA-2qmaA:
undetectable		 3hcnA-2qmaA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r44 UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF07726
(AAA_3) 		4 MET A  69
LEU A  65
PRO A 149
GLY A  45
 None
 1.09A 3hcnA-2r44A:
undetectable		 3hcnA-2r44A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE

(Streptomyces
avermitilis) 		PF05721
(PhyH) 		4 MET A 241
ARG A  50
GLY A  52
MET A  81
 None
 1.07A 3hcnA-2rdsA:
undetectable		 3hcnA-2rdsA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 116
PRO A  26
SER A  34
GLY A  22
 GOL  A1726 ( 4.8A)
None
None
None
 0.90A 3hcnA-2x40A:
2.4		 3hcnA-2x40A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		4 MET A 373
LEU A 367
SER A 268
GLY A 418
 None
None
FAD  A1463 (-3.3A)
GOL  A1474 (-3.6A)
 1.05A 3hcnA-2xryA:
2.9		 3hcnA-2xryA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ARG A  42
PRO A 402
SER A 350
GLY A  74
 None
 1.05A 3hcnA-2xsgA:
undetectable		 3hcnA-2xsgA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywi HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00578
(AhpC-TSA) 		4 LEU A  66
PRO A 152
SER A 150
GLY A 185
 None
 1.06A 3hcnA-2ywiA:
undetectable		 3hcnA-2ywiA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 298
PRO A 263
SER A 272
GLY A 290
 None
 1.05A 3hcnA-2zc8A:
3.1		 3hcnA-2zc8A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 4 LEU A 500
ARG A 461
PRO A 486
GLY A 517
 None
 0.95A 3hcnA-2zuxA:
undetectable		 3hcnA-2zuxA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 LEU A 677
ARG A 717
PRO A 556
GLY A 733
 None
 1.08A 3hcnA-3ahiA:
2.1		 3hcnA-3ahiA:
18.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 MET A  99
LEU A 101
PRO A 266
SER A 268
GLY A 306
 CHD  A   2 (-4.0A)
CHD  A   3 ( 4.9A)
CHD  A   2 ( 4.5A)
CHD  A   2 ( 4.4A)
CHD  A   2 ( 3.8A)
 0.89A 3hcnA-3aqiA:
54.1		 3hcnA-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 PRO A 236
SER A 237
GLY A 190
MET A 154
 None
 1.07A 3hcnA-3blwA:
undetectable		 3hcnA-3blwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		4 LEU A  90
ARG A  70
PRO A 123
SER A 169
 None
None
None
EDO  A1001 ( 4.5A)
 0.97A 3hcnA-3e3xA:
undetectable		 3hcnA-3e3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 158
ARG A 333
PRO A 145
GLY A 152
 None
 1.08A 3hcnA-3ekgA:
undetectable		 3hcnA-3ekgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feg CHOLINE/ETHANOLAMINE
KINASE

(Homo sapiens) 		PF01633
(Choline_kinase) 		4 LEU A  82
SER A 150
GLY A 132
MET A 261
 AMP  A 398 ( 4.7A)
AMP  A 398 ( 4.0A)
None
None
 1.04A 3hcnA-3fegA:
undetectable		 3hcnA-3fegA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffc CF34 ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 ARG D  71
PRO D  45
SER D  47
GLY D  93
 None
 1.08A 3hcnA-3ffcD:
undetectable		 3hcnA-3ffcD:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 MET A 126
LEU A  97
ARG A  89
GLY A 307
 None
 1.10A 3hcnA-3gvhA:
4.4		 3hcnA-3gvhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 LEU 3 397
PRO 3 402
GLY 3 508
MET 3 535
 None
 1.12A 3hcnA-3i9v3:
undetectable		 3hcnA-3i9v3:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5z FEM-3 MRNA-BINDING
FACTOR 2

(Caenorhabditis
elegans) 		PF00806
(PUF) 		4 LEU A 207
PRO A 169
SER A 172
GLY A 192
 None
 0.98A 3hcnA-3k5zA:
undetectable		 3hcnA-3k5zA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 MET A  46
LEU A  41
ARG A 420
SER A  97
GLY A  76
 None
 1.46A 3hcnA-3k8zA:
3.1		 3hcnA-3k8zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 LEU A 106
PRO A 307
SER A 305
GLY A 351
 None
 0.97A 3hcnA-3m6xA:
undetectable		 3hcnA-3m6xA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus) 		PF00704
(Glyco_hydro_18) 		4 ARG A 350
SER A 186
GLY A 329
MET A 278
 None
 1.10A 3hcnA-3n11A:
undetectable		 3hcnA-3n11A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		4 LEU A  49
ARG A  39
SER A 449
GLY A  45
 None
 1.10A 3hcnA-3nzpA:
undetectable		 3hcnA-3nzpA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 LEU A  53
PRO A 245
SER A 289
GLY A  40
 None
 1.05A 3hcnA-3ogrA:
undetectable		 3hcnA-3ogrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 LEU A 140
PRO A 114
SER A 119
GLY A 156
 None
 1.01A 3hcnA-3p2mA:
3.3		 3hcnA-3p2mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		4 LEU A 304
ARG A 349
SER A 458
GLY A 236
 None
 1.02A 3hcnA-3rdeA:
undetectable		 3hcnA-3rdeA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		PF01522
(Polysacc_deac_1) 		4 LEU A 111
PRO A  80
SER A  34
GLY A 126
 None
 1.09A 3hcnA-3rxzA:
undetectable		 3hcnA-3rxzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		4 MET B 287
LEU B 273
PRO B  12
GLY B 283
 None
 0.83A 3hcnA-3vsjB:
undetectable		 3hcnA-3vsjB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Thermus
thermophilus) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		4 MET A  48
LEU A  34
SER A  38
GLY A  15
 None
 1.11A 3hcnA-3w7bA:
2.2		 3hcnA-3w7bA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a29 ENGINEERED
RETRO-ALDOL ENZYME
RA95.0

(synthetic
construct) 		PF00218
(IGPS) 		4 LEU A 159
ARG A 182
SER A  81
GLY A 212
 None
MLT  A 300 ( 3.9A)
None
MLT  A 300 (-2.8A)
 1.09A 3hcnA-4a29A:
undetectable		 3hcnA-4a29A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ax2 RAP1B

(Serratia
marcescens) 		PF16695
(Tai4) 		4 LEU A  51
ARG A 122
SER A  59
GLY A 115
 None
 1.10A 3hcnA-4ax2A:
undetectable		 3hcnA-4ax2A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 LEU A 152
ARG A 216
PRO A 128
GLY A 111
 None
 0.91A 3hcnA-4cvuA:
undetectable		 3hcnA-4cvuA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 277
PRO A 220
SER A 247
GLY A 217
 None
 1.02A 3hcnA-4eutA:
undetectable		 3hcnA-4eutA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A  27
PRO A 231
SER A 229
GLY A 391
 None
 1.09A 3hcnA-4f32A:
2.1		 3hcnA-4f32A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 408
ARG A 299
SER A 178
GLY A 293
 None
 1.07A 3hcnA-4jgaA:
undetectable		 3hcnA-4jgaA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjp PHOSPHOMETHYLPYRIMID
INE KINASE

(Clostridioides
difficile) 		PF08543
(Phos_pyr_kin) 		4 MET A  82
LEU A 118
SER A 216
GLY A  19
 None
 1.12A 3hcnA-4jjpA:
3.9		 3hcnA-4jjpA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  44
PRO A  78
SER A  74
GLY A 270
 None
 1.10A 3hcnA-4jn7A:
2.1		 3hcnA-4jn7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  48
PRO A  78
SER A  74
GLY A 270
 None
 0.86A 3hcnA-4jn7A:
2.1		 3hcnA-4jn7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 LEU A  72
PRO A  48
SER A  53
GLY A  88
 None
 1.04A 3hcnA-4mydA:
2.8		 3hcnA-4mydA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of8 IRREGULAR CHIASM
C-ROUGHEST PROTEIN

(Drosophila
melanogaster) 		PF07679
(I-set)
PF08205
(C2-set_2) 		4 LEU A  67
PRO A  34
SER A 121
GLY A 125
 None
None
None
GOL  A 302 (-3.6A)
 0.80A 3hcnA-4of8A:
undetectable		 3hcnA-4of8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paw OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Helicobacter
pylori) 		PF00156
(Pribosyltran) 		4 LEU A 110
PRO A 164
GLY A 119
MET A 123
 None
None
PO4  A 302 (-3.2A)
None
 1.08A 3hcnA-4pawA:
undetectable		 3hcnA-4pawA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 978
PRO A 433
SER A 436
GLY A 983
 None
 0.95A 3hcnA-4ptfA:
undetectable		 3hcnA-4ptfA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pug BOLA LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01722
(BolA) 		4 LEU A  85
PRO A 153
SER A 156
GLY A 118
 None
 1.07A 3hcnA-4pugA:
undetectable		 3hcnA-4pugA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		4 LEU A 380
ARG A 424
SER A 411
GLY A 486
 None
 1.10A 3hcnA-4pxqA:
undetectable		 3hcnA-4pxqA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP

(Pseudomonas
putida) 		PF03480
(DctP) 		4 MET A 180
LEU A 163
PRO A 106
GLY A 230
 None
 1.11A 3hcnA-4xfeA:
undetectable		 3hcnA-4xfeA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 LEU A 387
ARG A 215
SER A 190
GLY A 380
 None
None
None
U5P  A 606 (-3.4A)
 0.87A 3hcnA-4xwtA:
4.1		 3hcnA-4xwtA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 MET A 835
LEU A 828
ARG A 802
SER A 572
 None
 1.09A 3hcnA-4yooA:
undetectable		 3hcnA-4yooA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS

(Bacillus
subtilis) 		PF00067
(p450) 		4 MET A 234
LEU A 216
ARG A 103
GLY A 354
 MET  A 234 ( 0.0A)
LEU  A 216 ( 0.6A)
ARG  A 103 (-0.6A)
GLY  A 354 (-0.0A)
 1.02A 3hcnA-4yzrA:
undetectable		 3hcnA-4yzrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		4 MET A  40
LEU A 255
SER A 493
GLY A 426
 None
 1.11A 3hcnA-5d2eA:
2.6		 3hcnA-5d2eA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		4 MET A1333
LEU A1329
PRO A1367
GLY A1370
 None
 1.07A 3hcnA-5deuA:
undetectable		 3hcnA-5deuA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4s CONTACTIN-4

(Mus musculus) 		PF00041
(fn3) 		4 LEU A 752
ARG A 759
SER A 789
GLY A 708
 None
 1.12A 3hcnA-5e4sA:
undetectable		 3hcnA-5e4sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Homo sapiens) 		PF00903
(Glyoxalase)
PF13669
(Glyoxalase_4) 		4 LEU A 367
PRO A 239
SER A 226
GLY A 358
 LEU  A 367 ( 0.6A)
PRO  A 239 ( 1.1A)
SER  A 226 ( 0.0A)
GLY  A 358 ( 0.0A)
 1.07A 3hcnA-5ec3A:
undetectable		 3hcnA-5ec3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		4 MET A 339
PRO A 740
SER A 332
GLY A 364
 None
 1.05A 3hcnA-5fbuA:
undetectable		 3hcnA-5fbuA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5u BETA-HEXOSAMINIDASE

(Pseudomonas
aeruginosa) 		PF00933
(Glyco_hydro_3) 		4 MET A   1
LEU A 291
PRO A 296
GLY A 272
 None
 1.10A 3hcnA-5g5uA:
undetectable		 3hcnA-5g5uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 272
PRO A 308
SER A 310
GLY A 282
 None
None
NAG  A 805 ( 4.8A)
SO4  A 807 (-3.9A)
 1.07A 3hcnA-5gr8A:
undetectable		 3hcnA-5gr8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		4 LEU A  42
PRO A 740
SER A 309
GLY A 723
 None
 1.03A 3hcnA-5gw7A:
undetectable		 3hcnA-5gw7A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7

(synthetic
construct;
Zika virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		4 MET A  51
LEU A1058
SER A1033
GLY A1133
 None
 0.94A 3hcnA-5gxjA:
undetectable		 3hcnA-5gxjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		4 MET A 204
LEU A 201
SER A 319
GLY A 326
 None
 1.00A 3hcnA-5hlbA:
undetectable		 3hcnA-5hlbA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 LEU A 408
PRO A 426
GLY A 422
MET A 380
 None
 0.94A 3hcnA-5hqnA:
undetectable		 3hcnA-5hqnA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		4 LEU A 410
PRO A 428
GLY A 424
MET A 382
 None
 0.92A 3hcnA-5i85A:
undetectable		 3hcnA-5i85A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7u MAJOR CAPSID PROTEIN

(Faustovirus) 		PF04451
(Capsid_NCLDV) 		4 MET A 102
LEU A 393
ARG A 319
GLY A  96
 None
 1.00A 3hcnA-5j7uA:
undetectable		 3hcnA-5j7uA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		4 LEU A 402
PRO A 435
SER A 437
GLY A  19
 None
None
None
FAD  A 601 (-3.3A)
 1.10A 3hcnA-5j7xA:
undetectable		 3hcnA-5j7xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		4 MET C 174
ARG C 245
SER C 150
GLY C 221
 None
 1.11A 3hcnA-5k1cC:
undetectable		 3hcnA-5k1cC:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03147
(FDX-ACB) 		4 MET A 258
LEU A 262
SER A 238
GLY A 277
 None
 1.07A 3hcnA-5mgvA:
undetectable		 3hcnA-5mgvA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		4 MET A  71
LEU A  74
SER A 143
GLY A 492
 None
 1.10A 3hcnA-5mrwA:
undetectable		 3hcnA-5mrwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		4 MET A  71
LEU A  74
SER A 143
GLY A 495
 None
None
None
PX4  A 602 ( 4.1A)
 1.06A 3hcnA-5mrwA:
undetectable		 3hcnA-5mrwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nws SAACMM

(Streptomyces
antibioticus) 		no annotation 4 MET A 260
LEU A 241
ARG A 127
GLY A 384
 None
None
HEM  A 504 (-4.0A)
HEM  A 504 (-3.4A)
 1.00A 3hcnA-5nwsA:
undetectable		 3hcnA-5nwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t87 CDII IMMUNITY
PROTEIN
CDIA TOXIN

(Cupriavidus
taiwanensis;
Cupriavidus
taiwanensis) 		no annotation
no annotation 		5 MET E 225
LEU E 221
ARG A  75
SER E 180
GLY E 213
 None
 1.46A 3hcnA-5t87E:
undetectable		 3hcnA-5t87E:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 4 LEU A 301
ARG A 193
SER A 249
GLY A 151
 None
 0.91A 3hcnA-5txfA:
3.2		 3hcnA-5txfA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 5 LEU A 410
ARG A 400
SER A 380
GLY A 394
MET A 386
 None
None
C2F  A3001 (-4.7A)
None
None
 1.08A 3hcnA-5vopA:
3.4		 3hcnA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 4 LEU A 170
ARG A 731
PRO A 596
GLY A 618
 None
 1.04A 3hcnA-5z9sA:
2.5		 3hcnA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 LEU A 347
SER A 235
GLY A 286
MET A 214
 None
 1.02A 3hcnA-5ze4A:
3.9		 3hcnA-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 4 LEU I 306
PRO I 268
SER I 297
GLY I 277
 None
 1.06A 3hcnA-6bnpI:
undetectable		 3hcnA-6bnpI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 4 MET A 226
LEU A 107
SER A 244
GLY A 186
 None
 0.93A 3hcnA-6c62A:
undetectable		 3hcnA-6c62A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C'

(Saccharomyces
cerevisiae) 		no annotation 4 LEU D  55
ARG D 125
PRO D  62
GLY D  42
 None
 1.02A 3hcnA-6c6lD:
undetectable		 3hcnA-6c6lD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0s TBC1 DOMAIN FAMILY
MEMBER 22B

(Homo sapiens) 		no annotation 4 MET A 355
LEU A 359
PRO A 317
MET A 415
 None
 0.94A 3hcnA-6d0sA:
undetectable		 3hcnA-6d0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eub ANGIOPOIETIN-RELATED
PROTEIN 4

(Homo sapiens) 		no annotation 4 LEU A 257
PRO A 399
SER A 271
GLY A 223
 None
 1.11A 3hcnA-6eubA:
undetectable		 3hcnA-6eubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h25 -

(-) 		no annotation 4 LEU A  98
PRO A 209
GLY A 219
MET A 217
 None
 1.03A 3hcnA-6h25A:
undetectable		 3hcnA-6h25A:
undetectable