SIMILAR PATTERNS OF AMINO ACIDS FOR 3HAV_B_SRYB403_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ham	AMINOGLYCOSIDE PHOSPHOTRANSFERASE (Enterococcus faecium)	PF01636 (APH)	6	ASP A 192 SER A 194 ASN A 261 ASP A 262 TRP A 265 ASP A 268	LLL A 500 (-2.8A) LLL A 500 (-3.3A) GOL A 301 (-3.3A) LLL A 500 (-3.7A) LLL A 500 (-3.8A) None	0.95A	3havB-3hamA: 37.9	3havB-3hamA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ham	AMINOGLYCOSIDE PHOSPHOTRANSFERASE (Enterococcus faecium)	PF01636 (APH)	7	ASP A 192 SER A 194 ASP A 213 CYH A 225 ASN A 261 TRP A 265 ASP A 268	LLL A 500 (-2.8A) LLL A 500 (-3.3A) LLL A 500 (-3.5A) GOL A 301 (-3.4A) GOL A 301 (-3.3A) LLL A 500 (-3.8A) None	0.82A	3havB-3hamA: 37.9	3havB-3hamA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ham	AMINOGLYCOSIDE PHOSPHOTRANSFERASE (Enterococcus faecium)	PF01636 (APH)	5	ASP A 213 ASN A 261 ASP A 262 TRP A 265 ASP A 268	LLL A 500 (-3.5A) GOL A 301 (-3.3A) LLL A 500 (-3.7A) LLL A 500 (-3.8A) None	1.37A	3havB-3hamA: 37.9	3havB-3hamA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5vtm	TYPE II SECRETION SYSTEM PROTEIN J TYPE II SECRETION SYSTEM PROTEIN K (Pseudomonas aeruginosa)	no annotation	5	ASP W 75 ASP W 71 ASN X 182 ASP X 157 ASP X 168	None None CA X 403 (-3.1A) CA X 402 ( 2.7A) None	1.42A	3havB-5vtmW: 0.0	3havB-5vtmW: 13.62

[["3HAV_B_SRYB403_1","3ham","Enterococcus faecium","AMINOGLYCOSIDE PHOSPHOTRANSFERASE","PF01636(APH)",6,"ASP A 192;SER A 194;ASN A 261;ASP A 262;TRP A 265;ASP A 268","LLL A 500 (-2.8A);LLL A 500 (-3.3A);GOL A 301 (-3.3A);LLL A 500 (-3.7A);LLL A 500 (-3.8A);None","0.95A","3havB-3hamA:37.9","3havB-3hamA:100.00"],["3HAV_B_SRYB403_1","3ham","Enterococcus faecium","AMINOGLYCOSIDE PHOSPHOTRANSFERASE","PF01636(APH)",7,"ASP A 192;SER A 194;ASP A 213;CYH A 225;ASN A 261;TRP A 265;ASP A 268","LLL A 500 (-2.8A);LLL A 500 (-3.3A);LLL A 500 (-3.5A);GOL A 301 (-3.4A);GOL A 301 (-3.3A);LLL A 500 (-3.8A);None","0.82A","3havB-3hamA:37.9","3havB-3hamA:100.00"],["3HAV_B_SRYB403_1","3ham","Enterococcus faecium","AMINOGLYCOSIDE PHOSPHOTRANSFERASE","PF01636(APH)",5,"ASP A 213;ASN A 261;ASP A 262;TRP A 265;ASP A 268","LLL A 500 (-3.5A);GOL A 301 (-3.3A);LLL A 500 (-3.7A);LLL A 500 (-3.8A);None","1.37A","3havB-3hamA:37.9","3havB-3hamA:100.00"],["3HAV_B_SRYB403_1","5vtm","Pseudomonas aeruginosa","TYPE II SECRETION SYSTEM PROTEIN J;TYPE II SECRETION SYSTEM PROTEIN K","no annotation",5,"ASP W  75;ASP W  71;ASN X 182;ASP X 157;ASP X 168","None;None; CA X 403 (-3.1A); CA X 402 ( 2.7A);None","1.42A","3havB-5vtmW:0.0","3havB-5vtmW:13.62"]]