SIMILAR PATTERNS OF AMINO ACIDS FOR 3HAV_A_SRYA403_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a99 PUTRESCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 ASP A 310
ASP A 247
ASP A 278
TYR A 336
 None
PUT  A 371 (-3.0A)
PUT  A 371 (-3.1A)
None
 0.80A 3havA-1a99A:
undetectable		 3havA-1a99A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		4 ASP A 193
SER A 192
ASP A 188
TRP A 182
 None
 0.92A 3havA-1b5dA:
undetectable		 3havA-1b5dA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		4 SER A 433
ASP A 515
ASP A 412
TYR A 320
 None
 1.21A 3havA-1crlA:
0.5		 3havA-1crlA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gud D-ALLOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		4 ASP A 227
ASP A 202
ASP A 113
TYR A 198
 None
 1.20A 3havA-1gudA:
0.0		 3havA-1gudA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idt MINOR FMN-DEPENDENT
NITROREDUCTASE

(Escherichia
coli) 		PF00881
(Nitroreductase) 		4 ASP A  91
ASP A  92
ASP A 134
TRP A 138
 None
 1.23A 3havA-1idtA:
0.8		 3havA-1idtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lj2 NONSTRUCTURAL
RNA-BINDING PROTEIN
34

(Rotavirus A) 		PF01665
(Rota_NSP3) 		4 ASP A 280
SER A 268
ASP A 279
ASP A 291
 None
 1.26A 3havA-1lj2A:
undetectable		 3havA-1lj2A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 SER A 354
ASP A 166
ASP A 350
ASP A 117
 None
 1.15A 3havA-1llaA:
0.0		 3havA-1llaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 SER A 101
ASP A 104
ASP A 252
TRP A 254
 None
 1.12A 3havA-1m2wA:
2.1		 3havA-1m2wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		4 ASP A  51
ASP A  54
ASP A  43
ASP A  32
 None
 1.20A 3havA-1qyiA:
undetectable		 3havA-1qyiA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul1 FLAP ENDONUCLEASE-1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ASP X  34
ASP X 179
CYH X 163
TYR X 234
 MG  X1001 (-3.4A)
MG  X1002 ( 4.0A)
None
None
 1.14A 3havA-1ul1X:
0.0		 3havA-1ul1X:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		4 ASP A  38
SER A  39
ASP A  92
ASP A 433
 None
 1.25A 3havA-1vg0A:
undetectable		 3havA-1vg0A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		4 ASP A  62
ASP A  64
ASP A  58
ASP A 207
 CA  A 404 ( 3.1A)
None
None
None
 1.04A 3havA-1wraA:
undetectable		 3havA-1wraA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		4 SER A 367
ASP A  72
ASP A 363
ASP A 145
 None
 1.10A 3havA-1x9yA:
undetectable		 3havA-1x9yA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		4 ASP A  37
ASP A  39
ASP A  33
ASP A 182
 CA  A1552 ( 3.2A)
None
None
None
 1.05A 3havA-2bibA:
undetectable		 3havA-2bibA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czq CUTINASE-LIKE
PROTEIN

(Cryptococcus
sp. S-2) 		PF01083
(Cutinase) 		4 ASP A 186
SER A 182
ASP A 165
ASP A 159
 None
 1.08A 3havA-2czqA:
undetectable		 3havA-2czqA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 ASP A 202
ASP A 176
TRP A 177
TYR A  80
 None
 1.21A 3havA-2douA:
undetectable		 3havA-2douA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsn HYPOTHETICAL PROTEIN
TA0583

(Thermoplasma
acidophilum) 		no annotation 4 SER A 199
ASP A 176
ASP A 114
TYR A 318
 None
MG  A 327 ( 4.2A)
None
None
 1.08A 3havA-2fsnA:
undetectable		 3havA-2fsnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gop TRILOBED PROTEASE

(Pyrococcus
furiosus) 		PF07676
(PD40) 		4 ASP A 225
SER A 224
ASP A 272
ASP A 114
 None
 1.16A 3havA-2gopA:
undetectable		 3havA-2gopA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsj PROTEIN PPL-2

(Parkia
platycephala) 		PF00704
(Glyco_hydro_18) 		4 ASP A 123
ASP A 125
ASP A 258
TYR A 182
 None
 0.99A 3havA-2gsjA:
undetectable		 3havA-2gsjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF03054
(tRNA_Me_trans) 		4 ASP A  42
ASP A  43
ASP A  81
TYR A 214
 None
 1.15A 3havA-2hmaA:
undetectable		 3havA-2hmaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2l YOPX PROTEIN

(Bacillus
subtilis) 		PF09643
(YopX) 		4 ASP A  18
ASP A  17
ASP A   9
TYR A  66
 None
 1.25A 3havA-2i2lA:
undetectable		 3havA-2i2lA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		4 ASP A 897
ASP A 893
ASP A 904
ASP A1176
 None
 1.09A 3havA-2j7nA:
undetectable		 3havA-2j7nA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA

(Pseudomonas
aeruginosa) 		PF13420
(Acetyltransf_4) 		4 ASP A  93
ASP A  92
ASP A  60
ASP A  12
 None
 1.11A 3havA-2j8mA:
undetectable		 3havA-2j8mA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 SER A 472
ASP A 382
ASP A  98
TRP A 369
 None
 1.18A 3havA-2jisA:
undetectable		 3havA-2jisA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jtc STREPTOPAIN

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10) 		4 SER A  10
ASP A 200
ASP A 219
TYR A  21
 None
 1.13A 3havA-2jtcA:
undetectable		 3havA-2jtcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8k NON-STRUCTURAL
PROTEIN 7

(Equine
arteritis virus) 		PF16749
(Arteri_nsp7a) 		4 ASP A  55
SER A  51
ASP A  57
ASP A  19
 None
 1.15A 3havA-2l8kA:
undetectable		 3havA-2l8kA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		4 SER A 616
ASP A 622
ASP A 500
ASP A 654
 None
 1.16A 3havA-2o3eA:
2.7		 3havA-2o3eA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pia PHTHALATE
DIOXYGENASE
REDUCTASE

(Burkholderia
cepacia) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ASP A 290
SER A 310
ASP A 293
ASP A 298
 None
 1.18A 3havA-2piaA:
undetectable		 3havA-2piaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		4 ASP A 162
SER A 156
ASP A 367
TYR A 222
 None
None
None
EDO  A 502 ( 4.3A)
 1.00A 3havA-2q14A:
undetectable		 3havA-2q14A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4k UNCHARACTERIZED
PROTEIN C11ORF68

(Homo sapiens) 		PF08939
(DUF1917) 		4 ASP A 206
SER A  90
ASP A  33
TRP A  78
 None
 1.21A 3havA-2q4kA:
undetectable		 3havA-2q4kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqk NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 ASP A  92
SER A 115
ASP A  99
TRP A 212
 None
 1.27A 3havA-2qqkA:
undetectable		 3havA-2qqkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys3 UNC-112-RELATED
PROTEIN 2

(Homo sapiens) 		PF00169
(PH) 		4 CYH A  94
ASP A  96
ASP A  13
TYR A 121
 None
 1.26A 3havA-2ys3A:
undetectable		 3havA-2ys3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt)
no annotation 		4 ASP A  73
SER A  76
ASP A  58
TYR B  86
 2DE  B 329 (-3.4A)
None
None
None
 1.21A 3havA-3aqcA:
2.6		 3havA-3aqcA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgy POLYNUCLEOTIDE
5'-TRIPHOSPHATASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 4 SER A  31
ASP A 220
ASP A  29
TYR A  20
 None
 1.26A 3havA-3bgyA:
undetectable		 3havA-3bgyA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 ASP A 344
ASP A 332
ASP A 384
TYR A 612
 TRS  A 800 (-2.6A)
TRS  A 800 (-3.6A)
None
None
 1.17A 3havA-3cihA:
undetectable		 3havA-3cihA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor) 		PF00704
(Glyco_hydro_18) 		4 ASP A 117
ASP A 119
ASP A 276
TYR A 181
 None
 0.97A 3havA-3ebvA:
undetectable		 3havA-3ebvA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go9 INSULINASE FAMILY
PROTEASE

(Yersinia pestis) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ASP A 412
ASP A  30
ASP A 396
TYR A 390
 None
None
ZN  A 601 (-3.4A)
None
 1.05A 3havA-3go9A:
undetectable		 3havA-3go9A:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		4 ASP A 192
ASP A 213
CYH A 225
TRP A 265
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
LLL  A 500 (-3.8A)
 0.99A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		4 ASP A 192
SER A 194
ASP A 213
CYH A 225
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
 0.86A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		4 ASP A 192
SER A 194
CYH A 225
ASP A 232
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.4A)
LLL  A 500 (-3.3A)
 0.91A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		4 ASP A 213
CYH A 225
TRP A 265
TYR A 272
 LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.21A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		4 SER A 194
ASP A 213
CYH A 225
TYR A 272
 LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
LLL  A 500 ( 4.7A)
 1.13A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ASP B 471
SER B 470
ASP B 425
ASP B 167
 None
None
CO  B 562 (-2.1A)
2PG  B 565 ( 2.4A)
 1.07A 3havA-3igzB:
undetectable		 3havA-3igzB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S35,
MITOCHONDRIAL
PENTATRICOPEPTIDE
REPEAT
DOMAIN-CONTAINING
PROTEIN 3,
MITOCHONDRIAL

(Bos taurus) 		PF00312
(Ribosomal_S15)
PF00411
(Ribosomal_S11) 		4 SER k  81
ASP o  91
ASP o  81
TYR o 522
 None
 0.96A 3havA-3jd5k:
undetectable		 3havA-3jd5k:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		4 ASP A  99
SER A 128
ASP A 125
ASP A 194
 None
 1.10A 3havA-3k55A:
undetectable		 3havA-3k55A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 ASP A 962
SER A 958
ASP A 964
ASP A 955
 None
 0.87A 3havA-3lj0A:
1.9		 3havA-3lj0A:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		4 ASP A 197
ASP A 220
TRP A 287
TYR A 282
 None
 1.18A 3havA-3n4tA:
30.4		 3havA-3n4tA:
34.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		4 ASP A 197
SER A 199
TRP A 287
TYR A 282
 None
 1.11A 3havA-3n4tA:
30.4		 3havA-3n4tA:
34.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		4 SER A  83
ASP A  89
ASP A 250
ASP A 238
 None
 1.15A 3havA-3nnkA:
undetectable		 3havA-3nnkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ASP A 470
ASP A 471
ASP A 465
ASP A 319
 None
None
CO  A 553 (-2.3A)
CO  A 554 (-2.4A)
 1.11A 3havA-3nvlA:
undetectable		 3havA-3nvlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohg UNCHARACTERIZED
PROTEIN FROM DUF2233
FAMILY

(Bacteroides
ovatus) 		PF09992
(NAGPA) 		4 ASP A  96
SER A 107
ASP A  97
ASP A 132
 EDO  A 406 ( 2.9A)
EDO  A 406 ( 3.8A)
EDO  A 413 (-3.4A)
None
 1.09A 3havA-3ohgA:
2.0		 3havA-3ohgA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpd CUTINASE 1

(Aspergillus
oryzae) 		PF01083
(Cutinase) 		4 ASP A 200
SER A 196
ASP A 203
ASP A 181
 None
 0.98A 3havA-3qpdA:
undetectable		 3havA-3qpdA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		4 ASP A 253
SER A 230
ASP A 294
TYR A 126
 None
None
CAC  A 370 (-2.4A)
UNL  A 372 (-4.3A)
 1.21A 3havA-3rhgA:
undetectable		 3havA-3rhgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 SER A 226
ASP A 222
ASP A 232
ASP A 378
 None
 1.26A 3havA-3s6hA:
undetectable		 3havA-3s6hA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 4 ASP A 274
SER A 286
ASP A 275
TYR A 208
 None
None
MG  A 501 ( 2.8A)
SAH  A 601 (-3.5A)
 1.25A 3havA-3ssmA:
undetectable		 3havA-3ssmA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2l PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
fragilis) 		PF13149
(Mfa_like_1) 		4 ASP A 140
ASP A 221
ASP A 227
TYR A 239
 None
 1.11A 3havA-3t2lA:
undetectable		 3havA-3t2lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Francisella
tularensis) 		PF00793
(DAHP_synth_1) 		4 SER A 327
ASP A 334
ASP A 330
ASP A 271
 None
None
MN  A1001 (-3.3A)
None
 1.27A 3havA-3tqkA:
undetectable		 3havA-3tqkA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utn THIOSULFATE
SULFURTRANSFERASE
TUM1

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 ASP X 136
ASP X  39
ASP X  57
TYR X  96
 None
 1.23A 3havA-3utnX:
undetectable		 3havA-3utnX:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9s OMPR FAMILY RESPONSE
REGULATOR IN
TWO-COMPONENT
REGULATORY SYSTEM
WITH BASS

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		4 ASP A   8
ASP A   9
ASP A  58
ASP A  86
 MG  A 202 (-2.6A)
None
None
None
 1.08A 3havA-3w9sA:
undetectable		 3havA-3w9sA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 ASP A 283
ASP A 280
ASP A 323
ASP A 491
 None
 1.11A 3havA-3wfzA:
undetectable		 3havA-3wfzA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 SER A 325
ASP A 320
ASP A 357
TYR A 364
 None
 1.27A 3havA-3zynA:
undetectable		 3havA-3zynA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 ASP A1082
ASP A1083
ASP A1112
ASP A1103
 None
 1.18A 3havA-4amcA:
undetectable		 3havA-4amcA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 ASP A 441
ASP A 484
ASP A 163
ASP A 156
 None
EDO  A1504 (-2.8A)
None
None
 1.19A 3havA-4c7gA:
undetectable		 3havA-4c7gA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		4 ASP A  42
SER A  45
ASP A  38
ASP A 307
 None
 1.24A 3havA-4gu7A:
undetectable		 3havA-4gu7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0p ACETATE KINASE

(Cryptococcus
neoformans) 		PF00871
(Acetate_kinase) 		4 SER A 235
ASP A 159
CYH A 228
ASP A 237
 None
 1.27A 3havA-4h0pA:
undetectable		 3havA-4h0pA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		4 ASP A 393
ASP A 394
ASP A 124
ASP A  52
 None
 1.26A 3havA-4haqA:
undetectable		 3havA-4haqA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina) 		PF00161
(RIP) 		4 ASP B 136
SER B  57
ASP B 133
ASP B  60
 None
 0.94A 3havA-4hr6B:
undetectable		 3havA-4hr6B:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7

(Homo sapiens) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 ASP A 165
ASP A 163
ASP A 260
TYR A 194
 MN  A 401 ( 2.7A)
UDP  A 402 (-3.3A)
None
UDP  A 402 (-4.6A)
 1.12A 3havA-4irqA:
undetectable		 3havA-4irqA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ASP A  74
SER A  77
TRP A 156
TYR A  99
 None
 1.18A 3havA-4lcyA:
undetectable		 3havA-4lcyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdy PERIPLASMIC BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01497
(Peripla_BP_2) 		4 ASP A  65
ASP A  64
ASP A 158
ASP A 221
 None
 0.91A 3havA-4mdyA:
undetectable		 3havA-4mdyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlz PERIPLASMIC BINDING
PROTEIN

(Jonesia
denitrificans) 		PF01497
(Peripla_BP_2) 		4 ASP A 293
SER A 298
ASP A 327
ASP A 321
 None
 1.21A 3havA-4mlzA:
undetectable		 3havA-4mlzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 SER A 247
ASP A 244
ASP A 775
TYR A 160
 None
P5F  A1101 (-3.2A)
None
None
 1.18A 3havA-4nmeA:
undetectable		 3havA-4nmeA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Mycobacterium
tuberculosis) 		PF01497
(Peripla_BP_2) 		4 ASP A  44
ASP A  43
ASP A 137
ASP A 200
 None
 1.06A 3havA-4pm4A:
undetectable		 3havA-4pm4A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Mycobacterium
tuberculosis) 		PF01497
(Peripla_BP_2) 		4 ASP A  44
ASP A  43
ASP A 200
TRP A 197
 None
 1.23A 3havA-4pm4A:
undetectable		 3havA-4pm4A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpa PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ASP A 256
SER A 260
ASP A 223
ASP A 183
 None
 1.26A 3havA-4rpaA:
undetectable		 3havA-4rpaA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR

(Klebsiella
pneumoniae) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 ASP A   8
ASP A   9
ASP A  58
ASP A  86
 MG  A 302 (-2.7A)
None
None
None
 1.12A 3havA-4s05A:
undetectable		 3havA-4s05A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toq CLASS III CHITINASE

(Punica granatum) 		PF00704
(Glyco_hydro_18) 		4 ASP A 123
ASP A 125
ASP A 262
TYR A 183
 None
 1.00A 3havA-4toqA:
undetectable		 3havA-4toqA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trk C. ELEGANS HIM-3

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		4 ASP A 142
ASP A 247
ASP A 219
TYR A 214
 None
 1.25A 3havA-4trkA:
1.5		 3havA-4trkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 ASP A 177
ASP A 499
ASP A 495
TRP A 197
 None
 0.97A 3havA-4wjsA:
2.8		 3havA-4wjsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		4 ASP A 268
SER A  70
ASP A 269
TYR A 212
 MG  A1000 (-2.7A)
None
None
None
 1.23A 3havA-4x9eA:
2.1		 3havA-4x9eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		4 ASP A 311
SER A 302
ASP A 506
TYR A 374
 DGT  A 701 (-2.4A)
None
None
DGT  A 701 (-3.5A)
 1.14A 3havA-4zweA:
undetectable		 3havA-4zweA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		4 ASP A 104
ASP A 213
ASP A 182
TYR A 193
 None
ACT  A1479 (-2.6A)
CA  A1480 (-2.4A)
None
 1.20A 3havA-5a2aA:
undetectable		 3havA-5a2aA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 ASP A 223
SER A 221
ASP A 225
ASP A 214
 None
 1.21A 3havA-5cslA:
undetectable		 3havA-5cslA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		4 ASP A 323
ASP A 328
TRP A 364
TYR A 270
 None
MG  A 502 (-3.4A)
None
None
 1.25A 3havA-5cuvA:
undetectable		 3havA-5cuvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cux ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		4 ASP A 323
ASP A 328
TRP A 364
TYR A 270
 POP  A 802 (-2.8A)
None
None
None
 1.27A 3havA-5cuxA:
undetectable		 3havA-5cuxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 ASP B 553
ASP B 552
ASP B 472
ASP B 637
 None
 1.18A 3havA-5dlqB:
1.2		 3havA-5dlqB:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hec PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)

(Streptococcus
parasanguinis) 		PF00535
(Glycos_transf_2) 		4 ASP A  92
SER A 168
ASP A  94
ASP A 230
 None
 0.94A 3havA-5hecA:
undetectable		 3havA-5hecA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn1 INTERLEUKIN-37

(Homo sapiens) 		PF00340
(IL1) 		4 SER A 169
ASP A 191
CYH A 122
ASP A 125
 None
 1.04A 3havA-5hn1A:
undetectable		 3havA-5hn1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8d OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE

(Enterobacter
cloacae) 		PF00881
(Nitroreductase) 		4 ASP A  91
ASP A  92
ASP A 134
TRP A 138
 None
 1.19A 3havA-5j8dA:
undetectable		 3havA-5j8dA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASP A 553
ASP A 554
ASP A 600
ASP A 153
 None
 1.24A 3havA-5ju6A:
undetectable		 3havA-5ju6A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 ASP A 231
SER A 238
ASP A  48
ASP A  75
 None
 1.24A 3havA-5l46A:
undetectable		 3havA-5l46A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus) 		PF00346
(Complex1_49kDa) 		4 ASP D 422
CYH D 299
ASP D 295
TRP D 235
 None
 1.22A 3havA-5lc5D:
undetectable		 3havA-5lc5D:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4s TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT
2,TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT
1,TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1

(Homo sapiens) 		no annotation 4 ASP A 122
SER A 118
ASP A 126
ASP A 189
 None
 1.13A 3havA-5m4sA:
2.1		 3havA-5m4sA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufl PROTEIN CIP2A

(Homo sapiens) 		no annotation 4 SER A 296
ASP A 292
ASP A 246
TYR A 129
 None
 1.26A 3havA-5uflA:
undetectable		 3havA-5uflA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ASP A  95
ASP A 621
ASP A 101
TYR A 368
 None
 1.24A 3havA-5xh9A:
undetectable		 3havA-5xh9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 ASP A1729
SER A1685
ASP A1731
TYR A1803
 None
 1.24A 3havA-5y29A:
undetectable		 3havA-5y29A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 4 SER A 128
ASP A 125
ASP A 121
TYR A 350
 GOL  A 409 ( 4.9A)
None
None
LOP  A 402 (-4.0A)
 1.05A 3havA-6bqcA:
undetectable		 3havA-6bqcA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwl PAL

(Bacillus
thuringiensis) 		no annotation 4 ASP A 215
ASP A 247
ASP A 221
ASP A 300
 EDO  A 405 (-4.4A)
NA  A 409 (-3.3A)
None
None
 1.00A 3havA-6bwlA:
undetectable		 3havA-6bwlA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 590
SER A 594
ASP A 616
TYR A 599
 None
 1.25A 3havA-6eojA:
2.3		 3havA-6eojA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 ASP A2499
ASP A1956
ASP A2236
TRP A1960
 None
 1.25A 3havA-6fb3A:
2.7		 3havA-6fb3A:
13.04