SIMILAR PATTERNS OF AMINO ACIDS FOR 3HAM_B_LLLB500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		5 ASN A 273
CYH A 228
ASP A 227
ASP A 250
ASP A 205
 None
 1.50A 3hamB-3bz5A:
0.0		 3hamB-3bz5A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		5 SER A 275
ASP A 282
SER A 266
ASP A 272
ARG A 135
 None
 1.47A 3hamB-3c1oA:
0.0		 3hamB-3c1oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ASP A 249
CYH A 212
ASP A 157
SER A  93
ASP A  33
 None
None
DQR  A 800 (-3.1A)
DQR  A 800 (-3.0A)
DQR  A 800 (-3.0A)
 1.21A 3hamB-3uggA:
0.0		 3hamB-3uggA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ASP A 418
ASN A 416
SER A 487
ASP A 424
ASP A 489
 None
 1.29A 3hamB-3v8xA:
0.0		 3hamB-3v8xA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 ASP A1024
ASP A1509
ASP A1027
ASP A1067
ARG A1199
 None
 1.40A 3hamB-4amcA:
0.9		 3hamB-4amcA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 ASP A1025
ASP A1504
ASP A1028
ASP A1069
ARG A1202
 GOL  A2773 ( 2.9A)
None
GOL  A2792 (-3.4A)
GOL  A2792 (-3.7A)
None
 1.37A 3hamB-4aygA:
1.0		 3hamB-4aygA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3h ARGINASE (ROCF)

(Helicobacter
pylori) 		PF00491
(Arginase) 		5 SER A  88
ASN A  93
ASP A  18
ASP A 234
ASP A 236
 None
None
None
MN  A 501 ( 2.8A)
MN  A 501 (-2.3A)
 1.33A 3hamB-4g3hA:
0.0		 3hamB-4g3hA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 ASP A 492
ASP A 460
ASP A 581
SER A 583
ASP A 557
 None
 1.35A 3hamB-4k17A:
0.0		 3hamB-4k17A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		5 ASP A  79
SER A  22
ASP A  81
ASP A 187
ASP A  19
 None
 1.32A 3hamB-5k52A:
1.6		 3hamB-5k52A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 ASP A2786
SER A2787
SER A2310
ASP A2295
ARG A2012
 None
 1.09A 3hamB-6fb3A:
0.0		 3hamB-6fb3A:
13.04