SIMILAR PATTERNS OF AMINO ACIDS FOR 3HAM_A_LLLA500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu4 ORNITHINE
DECARBOXYLASE

(Trypanosoma
brucei) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ASP A  38
ASN A 319
SER A 325
ASP A 320
TYR A 406
 None
 1.50A 3hamA-1qu4A:
0.0		 3hamA-1qu4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 5 SER A 231
ASP A 196
ASP A  52
ASP A  34
TYR A 169
 None
None
None
MG  A 601 (-2.4A)
None
 1.30A 3hamA-2f9rA:
0.0		 3hamA-2f9rA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ASP A 382
ASP A 408
ASP A  60
ASP A  64
TYR A  15
 None
 1.49A 3hamA-2ze0A:
1.5		 3hamA-2ze0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		5 ASN A 273
CYH A 228
ASP A 227
ASP A 250
ASP A 205
 None
 1.43A 3hamA-3bz5A:
0.0		 3hamA-3bz5A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ASN B 721
ASP A 797
SER B 690
ASP B 693
ARG A 693
 None
 1.03A 3hamA-3h0gB:
0.3		 3hamA-3h0gB:
12.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		5 ASP A 197
SER A 199
ASP A 220
TRP A 271
TYR A 278
 None
 0.92A 3hamA-3n4tA:
32.6		 3hamA-3n4tA:
34.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 ASP A  49
SER A  47
ASP A 243
SER A 246
ARG A 124
 GPJ  A 429 ( 4.7A)
None
None
None
GPJ  A 429 (-3.0A)
 1.44A 3hamA-3nvsA:
0.0		 3hamA-3nvsA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 SER A 129
ASN A  37
ASP A 138
ASP A 142
TYR A  86
 None
 1.19A 3hamA-3psgA:
undetectable		 3hamA-3psgA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 ASP A 492
ASP A 460
ASP A 581
SER A 583
ASP A 557
 None
 1.33A 3hamA-4k17A:
3.1		 3hamA-4k17A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		5 ASP A  79
SER A  22
ASP A  81
ASP A 187
ASP A  19
 None
 1.35A 3hamA-5k52A:
1.0		 3hamA-5k52A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		5 SER A 129
ASN A  37
ASP A 138
ASP A 142
TYR A  86
 None
 1.19A 3hamA-5pepA:
undetectable		 3hamA-5pepA:
22.41