SIMILAR PATTERNS OF AMINO ACIDS FOR 3H6T_A_CYZA265

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE

(Bacillus
subtilis) 		PF14562
(Endonuc_BglI) 		5 PRO A 290
LEU A 285
SER A 239
LEU A  35
ILE A 288
 None
 1.35A 3h6tA-1dmuA:
undetectable
3h6tC-1dmuA:
undetectable		 3h6tA-1dmuA:
23.81
3h6tC-1dmuA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jya YOPE REGULATOR

(Yersinia
pseudotuberculosis) 		PF05932
(CesT) 		5 PRO A  94
LEU A  74
SER A 102
LEU A  98
ILE A  73
 None
 1.41A 3h6tA-1jyaA:
undetectable
3h6tC-1jyaA:
undetectable		 3h6tA-1jyaA:
17.74
3h6tC-1jyaA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		5 SER A 490
LEU A 504
LEU A 485
LYS A 483
ILE A 500
 None
 1.41A 3h6tA-1m9iA:
undetectable
3h6tC-1m9iA:
undetectable		 3h6tA-1m9iA:
18.29
3h6tC-1m9iA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sax METHICILLIN
RESISTANCE
REGULATORY PROTEIN
MECI

(Staphylococcus
aureus) 		PF03965
(Penicillinase_R) 		5 LYS A  55
LEU A  52
SER A  71
LEU A  72
ILE A   8
 None
 1.47A 3h6tA-1saxA:
undetectable
3h6tC-1saxA:
undetectable		 3h6tA-1saxA:
19.38
3h6tC-1saxA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Toxoplasma
gondii) 		no annotation 5 PRO D 165
SER D 116
LEU D 196
LEU D  73
ILE D 233
 None
 1.37A 3h6tA-1upfD:
undetectable
3h6tC-1upfD:
undetectable		 3h6tA-1upfD:
19.15
3h6tC-1upfD:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lm5 CALCIUM AND
INTEGRIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 SER A 145
LEU A 144
ILE A 153
SER A 147
LYS A 150
 None
 1.44A 3h6tA-2lm5A:
undetectable
3h6tC-2lm5A:
undetectable		 3h6tA-2lm5A:
21.13
3h6tC-2lm5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		5 PRO A 343
LEU A 340
LEU A  59
ILE A 346
SER A  61
 None
 1.43A 3h6tA-2qzuA:
undetectable
3h6tC-2qzuA:
undetectable		 3h6tA-2qzuA:
18.95
3h6tC-2qzuA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		5 LEU A 135
SER A 139
LEU A 142
ILE A 158
SER A 152
 None
 1.12A 3h6tA-2vn7A:
undetectable
3h6tC-2vn7A:
undetectable		 3h6tA-2vn7A:
18.80
3h6tC-2vn7A:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		6 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.84A 3h6tA-2znsA:
37.2
3h6tC-2znsA:
37.4		 3h6tA-2znsA:
52.87
3h6tC-2znsA:
52.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 CUBILIN

(Homo sapiens) 		PF00431
(CUB) 		5 SER B1233
LEU B1205
SER B1250
ILE B1257
SER B1254
 None
 1.49A 3h6tA-3kq4B:
undetectable
3h6tC-3kq4B:
undetectable		 3h6tA-3kq4B:
20.00
3h6tC-3kq4B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 PRO A 287
LEU A 294
SER A 292
LEU A 306
LYS A 429
 None
 1.17A 3h6tA-3nksA:
undetectable
3h6tC-3nksA:
undetectable		 3h6tA-3nksA:
19.96
3h6tC-3nksA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		6 LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
 None
 0.88A 3h6tA-3qxmA:
37.1
3h6tC-3qxmA:
37.0		 3h6tA-3qxmA:
52.09
3h6tC-3qxmA:
52.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 LEU A1688
LEU A1799
LYS A1794
ILE A1466
SER A1487
 None
 1.45A 3h6tA-3rytA:
undetectable
3h6tC-3rytA:
undetectable		 3h6tA-3rytA:
18.87
3h6tC-3rytA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LYS A 478
LEU A 133
SER A 129
LEU A 127
ILE A 182
 None
 1.40A 3h6tA-3sdqA:
undetectable
3h6tC-3sdqA:
undetectable		 3h6tA-3sdqA:
15.30
3h6tC-3sdqA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc3 UV DAMAGE
ENDONUCLEASE

(Sulfolobus
acidocaldarius) 		PF03851
(UvdE) 		5 LYS A  78
LEU A  31
SER A  35
LEU A  38
LYS A  42
 None
 1.04A 3h6tA-3tc3A:
undetectable
3h6tC-3tc3A:
undetectable		 3h6tA-3tc3A:
24.54
3h6tC-3tc3A:
24.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		6 LYS A 103
PRO A 104
MET A 106
LEU A 234
LEU A 242
LYS A 246
 None
None
None
None
None
ZN  A 259 (-3.5A)
 0.76A 3h6tA-3u92A:
37.4
3h6tC-3u92A:
37.3		 3h6tA-3u92A:
52.09
3h6tC-3u92A:
52.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		5 PRO A 292
LEU A 294
LEU A 142
ILE A 223
SER A 156
 None
 1.23A 3h6tA-3zm8A:
undetectable
3h6tC-3zm8A:
undetectable		 3h6tA-3zm8A:
19.75
3h6tC-3zm8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmb GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 PRO A  24
LEU A 138
LEU A  27
ILE A 149
SER A 152
 None
 1.44A 3h6tA-4bmbA:
undetectable
3h6tC-4bmbA:
undetectable		 3h6tA-4bmbA:
20.41
3h6tC-4bmbA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		5 SER A  80
LEU A 101
LEU A  25
ILE A  70
SER A  22
 None
 1.21A 3h6tA-4ns4A:
undetectable
3h6tC-4ns4A:
undetectable		 3h6tA-4ns4A:
20.36
3h6tC-4ns4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux3 MITOTIC CHROMOSOME
DETERMINANT-RELATED
PROTEIN
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N)
PF04825
(Rad21_Rec8_N) 		5 LYS A1034
SER B  54
LEU A 179
LEU B  68
ILE A1030
 None
 0.96A 3h6tA-4ux3A:
undetectable
3h6tC-4ux3A:
undetectable		 3h6tA-4ux3A:
19.78
3h6tC-4ux3A:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.79A 3h6tA-4wxjA:
36.7
3h6tC-4wxjA:
36.4		 3h6tA-4wxjA:
40.36
3h6tC-4wxjA:
40.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dtb CG3822

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.56A 3h6tA-5dtbA:
38.4
3h6tC-5dtbA:
39.1		 3h6tA-5dtbA:
54.14
3h6tC-5dtbA:
54.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzg GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 PRO A  24
LEU A 138
LEU A  27
ILE A 149
SER A 152
 None
 1.41A 3h6tA-5gzgA:
undetectable
3h6tC-5gzgA:
undetectable		 3h6tA-5gzgA:
20.91
3h6tC-5gzgA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ict GLUTAMATE RECEPTOR 1

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 1.00A 3h6tA-5ictA:
39.2
3h6tC-5ictA:
39.1		 3h6tA-5ictA:
56.34
3h6tC-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikb GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4,GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 PRO A 104
MET A 106
LEU A 235
LEU A 243
LYS A 247
 None
 0.37A 3h6tA-5ikbA:
36.7
3h6tC-5ikbA:
36.7		 3h6tA-5ikbA:
55.73
3h6tC-5ikbA:
55.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix1 MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3

(Mus musculus) 		PF07496
(zf-CW)
PF13589
(HATPase_c_3) 		5 PRO A 146
LEU A 135
SER A 131
ILE A 138
SER A 173
 None
 1.21A 3h6tA-5ix1A:
undetectable
3h6tC-5ix1A:
undetectable		 3h6tA-5ix1A:
21.93
3h6tC-5ix1A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		7 LYS A 493
PRO A 494
MET A 496
LEU A 751
SER A 754
LEU A 759
LYS A 763
 None
 0.59A 3h6tA-5l1bA:
22.5
3h6tC-5l1bA:
22.4		 3h6tA-5l1bA:
34.90
3h6tC-5l1bA:
34.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		6 PRO A 494
MET A 496
SER A 497
SER A 754
LEU A 759
LYS A 763
 None
 0.54A 3h6tA-5l1bA:
22.5
3h6tC-5l1bA:
22.4		 3h6tA-5l1bA:
34.90
3h6tC-5l1bA:
34.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uje SBNI PROTEIN

(Staphylococcus
aureus) 		no annotation 5 LEU A  66
SER A  65
LEU A  27
ILE A  40
SER A  32
 None
 1.48A 3h6tA-5ujeA:
undetectable
3h6tC-5ujeA:
undetectable		 3h6tA-5ujeA:
16.15
3h6tC-5ujeA:
16.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		8 LYS A 493
PRO A 494
MET A 496
SER A 497
LEU A 751
SER A 754
LEU A 759
LYS A 763
 None
 1.03A 3h6tA-5welA:
32.6
3h6tC-5welA:
32.4		 3h6tA-5welA:
34.03
3h6tC-5welA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
MET A 496
SER A 497
LEU A 751
LEU A 759
 None
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
None
 0.69A 3h6tA-5weoA:
25.6
3h6tC-5weoA:
25.4		 3h6tA-5weoA:
34.03
3h6tC-5weoA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
MET A 496
SER A 497
LEU A 759
LYS A 763
 None
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
CYZ  A1302 (-2.9A)
 0.99A 3h6tA-5weoA:
25.6
3h6tC-5weoA:
25.4		 3h6tA-5weoA:
34.03
3h6tC-5weoA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
MET A 496
SER A 754
LEU A 759
LYS A 763
 None
CYZ  A1302 (-4.3A)
CYZ  A1302 ( 4.1A)
None
CYZ  A1302 (-2.9A)
 0.97A 3h6tA-5weoA:
25.6
3h6tC-5weoA:
25.4		 3h6tA-5weoA:
34.03
3h6tC-5weoA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
PRO A 494
MET A 496
SER A 497
LEU A 751
 None
CYZ  A1302 (-4.5A)
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
 0.68A 3h6tA-5weoA:
25.6
3h6tC-5weoA:
25.4		 3h6tA-5weoA:
34.03
3h6tC-5weoA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yay KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1

(Mus musculus) 		no annotation 5 LYS A1259
LEU A1293
LEU A1246
ILE A1255
SER A1251
 None
 1.44A 3h6tA-5yayA:
undetectable
3h6tC-5yayA:
undetectable		 3h6tA-5yayA:
16.02
3h6tC-5yayA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 5 PRO A1850
SER A1852
LEU A1841
LEU A1735
SER A1737
 None
 1.26A 3h6tA-5zalA:
undetectable
3h6tC-5zalA:
undetectable		 3h6tA-5zalA:
13.08
3h6tC-5zalA:
13.08