SIMILAR PATTERNS OF AMINO ACIDS FOR 3H5G_C_LEIC16

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 103
GLN A  53
LEU A  51
GLU A  37
 None
 1.01A 3h5gB-1cliA:
undetectable
3h5gC-1cliA:
undetectable		 3h5gB-1cliA:
8.37
3h5gC-1cliA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddb PROTEIN (BID)

(Mus musculus) 		PF06393
(BID) 		4 LEU A  38
GLN A  33
LEU A  35
GLU A  34
 None
 1.08A 3h5gB-1ddbA:
undetectable
3h5gC-1ddbA:
undetectable		 3h5gB-1ddbA:
10.26
3h5gC-1ddbA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 402
GLN A 375
LEU A 373
GLU A 378
 None
 1.10A 3h5gB-1ezvA:
undetectable
3h5gC-1ezvA:
undetectable		 3h5gB-1ezvA:
5.91
3h5gC-1ezvA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		4 LYS A  12
GLN A  92
LEU A  94
GLU A  96
 None
 0.96A 3h5gB-1j3bA:
undetectable
3h5gC-1j3bA:
undetectable		 3h5gB-1j3bA:
4.37
3h5gC-1j3bA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		4 LEU A  27
GLN A  32
LEU A  28
GLU A  31
 None
 1.11A 3h5gB-1jikA:
undetectable
3h5gC-1jikA:
undetectable		 3h5gB-1jikA:
4.05
3h5gC-1jikA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 266
GLN A 230
LEU A 232
GLU A 233
 None
 1.02A 3h5gB-1krhA:
undetectable
3h5gC-1krhA:
undetectable		 3h5gB-1krhA:
7.67
3h5gC-1krhA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwu FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Petromyzon
marinus;
Petromyzon
marinus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C) 		4 LEU C 123
LYS B 199
GLN B 201
GLU B 204
 None
 1.11A 3h5gB-1lwuC:
undetectable
3h5gC-1lwuC:
undetectable		 3h5gB-1lwuC:
5.35
3h5gC-1lwuC:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN

(Gallus gallus;
Gallus gallus) 		PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 LYS B 183
LEU B 187
LEU A 151
GLU A 152
 None
 1.03A 3h5gB-1m1jB:
undetectable
3h5gC-1m1jB:
undetectable		 3h5gB-1m1jB:
5.29
3h5gC-1m1jB:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Gallus gallus;
Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 LEU C 124
LYS B 183
GLN B 185
GLU B 188
 None
 1.06A 3h5gB-1m1jC:
undetectable
3h5gC-1m1jC:
undetectable		 3h5gB-1m1jC:
7.64
3h5gC-1m1jC:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Gallus gallus;
Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 LYS C 120
LEU C 124
LYS B 183
GLU B 188
 None
 1.09A 3h5gB-1m1jC:
undetectable
3h5gC-1m1jC:
undetectable		 3h5gB-1m1jC:
7.64
3h5gC-1m1jC:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Gallus gallus;
Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 LYS C 120
LYS B 183
LEU B 187
GLU B 188
 None
 1.07A 3h5gB-1m1jC:
undetectable
3h5gC-1m1jC:
undetectable		 3h5gB-1m1jC:
7.64
3h5gC-1m1jC:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 LEU A1101
GLN A1057
LEU A1102
GLU A1124
 None
 1.08A 3h5gB-1ofeA:
undetectable
3h5gC-1ofeA:
undetectable		 3h5gB-1ofeA:
2.79
3h5gC-1ofeA:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI

(Moraxella sp.) 		PF09208
(Endonuc-MspI) 		4 LEU A 174
GLN A 167
LEU A 171
GLU A 146
 None
 1.08A 3h5gB-1sa3A:
undetectable
3h5gC-1sa3A:
undetectable		 3h5gB-1sa3A:
7.91
3h5gC-1sa3A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 LYS A 483
LEU A 484
GLN A 542
LEU A 544
 None
 1.06A 3h5gB-1t1eA:
undetectable
3h5gC-1t1eA:
undetectable		 3h5gB-1t1eA:
8.97
3h5gC-1t1eA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LYS A  24
LEU A  26
GLN A 235
GLU A 238
 None
 1.12A 3h5gB-1uxiA:
undetectable
3h5gC-1uxiA:
undetectable		 3h5gB-1uxiA:
6.47
3h5gC-1uxiA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		4 LYS B 208
GLN B 210
LEU B 212
GLU B 213
 None
 0.84A 3h5gB-1wdwB:
undetectable
3h5gC-1wdwB:
undetectable		 3h5gB-1wdwB:
6.67
3h5gC-1wdwB:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		4 LYS A 235
GLN A 237
LEU A 239
GLU A 240
 None
 1.12A 3h5gB-1x1qA:
undetectable
3h5gC-1x1qA:
undetectable		 3h5gB-1x1qA:
5.53
3h5gC-1x1qA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 LEU A 199
GLN A 390
LEU A 392
GLU A 393
 None
 1.10A 3h5gB-1xzqA:
undetectable
3h5gC-1xzqA:
undetectable		 3h5gB-1xzqA:
4.56
3h5gC-1xzqA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yke RNA POLYMERASE II
MEDIATOR COMPLEX
PROTEIN MED7

(Saccharomyces
cerevisiae) 		PF05983
(Med7) 		4 LEU A 122
GLN A 117
LEU A 119
GLU A 118
 None
 1.12A 3h5gB-1ykeA:
undetectable
3h5gC-1ykeA:
undetectable		 3h5gB-1ykeA:
12.96
3h5gC-1ykeA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		4 LYS A 298
GLN A 285
LEU A 283
GLU A 284
 None
 1.12A 3h5gB-1yvlA:
undetectable
3h5gC-1yvlA:
undetectable		 3h5gB-1yvlA:
7.67
3h5gC-1yvlA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3x PUTATIVE
CYTIDYLYLTRANSFERASE

(Thermosynechococcus
elongatus) 		PF05419
(GUN4)
PF16416
(GUN4_N) 		4 LEU A 104
GLN A  99
LEU A 101
GLU A 100
 None
 0.97A 3h5gB-1z3xA:
undetectable
3h5gC-1z3xA:
undetectable		 3h5gB-1z3xA:
11.80
3h5gC-1z3xA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avx REGULATORY PROTEIN
SDIA

(Escherichia
coli) 		PF03472
(Autoind_bind) 		4 LEU A 133
LYS A 153
GLN A 155
LEU A 157
 None
 1.00A 3h5gB-2avxA:
undetectable
3h5gC-2avxA:
undetectable		 3h5gB-2avxA:
9.47
3h5gC-2avxA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Staphylococcus
aureus) 		PF01039
(Carboxyl_trans) 		4 LEU B 195
GLN B 281
LEU B 196
GLU B 282
 None
 1.13A 3h5gB-2f9iB:
undetectable
3h5gC-2f9iB:
undetectable		 3h5gB-2f9iB:
9.27
3h5gC-2f9iB:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		4 LEU A 113
LYS A 208
GLN A 210
LEU A 212
 None
 0.97A 3h5gB-2h1yA:
undetectable
3h5gC-2h1yA:
undetectable		 3h5gB-2h1yA:
7.17
3h5gC-2h1yA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlv XISI PROTEIN-LIKE

(Trichormus
variabilis) 		PF08869
(XisI) 		4 LEU A  83
LYS A   6
GLN A   8
LEU A  10
 None
 1.08A 3h5gB-2nlvA:
undetectable
3h5gC-2nlvA:
undetectable		 3h5gB-2nlvA:
10.81
3h5gC-2nlvA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 LEU A 302
GLN A 318
LEU A 316
GLU A 317
 None
 1.14A 3h5gB-2nyaA:
undetectable
3h5gC-2nyaA:
undetectable		 3h5gB-2nyaA:
3.90
3h5gC-2nyaA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p28 INTEGRIN BETA-2
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF17205
(PSI_integrin)
no annotation 		4 LEU A  62
GLN B 418
LEU A  83
GLU A  64
 None
 1.07A 3h5gB-2p28A:
undetectable
3h5gC-2p28A:
undetectable		 3h5gB-2p28A:
14.61
3h5gC-2p28A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		4 LEU A  35
GLN A  26
LEU A  28
GLU A  29
 None
 1.05A 3h5gB-2pcqA:
undetectable
3h5gC-2pcqA:
undetectable		 3h5gB-2pcqA:
8.19
3h5gC-2pcqA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
KINETOCHORE PROTEIN
NUF2, KINETOCHORE
PROTEIN SPC24

(Homo sapiens;
Homo sapiens) 		PF03801
(Ndc80_HEC)
PF08234
(Spindle_Spc25)
PF03800
(Nuf2)
PF08286
(Spc24) 		5 LYS C 151
LEU C 155
LYS A 264
LEU A 268
GLU A 269
 None
 1.35A 3h5gB-2ve7C:
undetectable
3h5gC-2ve7C:
undetectable		 3h5gB-2ve7C:
9.55
3h5gC-2ve7C:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 LYS A 130
LEU A 131
LEU A 143
GLU A 142
 None
 1.07A 3h5gB-2wgyA:
undetectable
3h5gC-2wgyA:
undetectable		 3h5gB-2wgyA:
6.16
3h5gC-2wgyA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmy PUTATIVE ACID
PHOSPHATASE WZB

(Escherichia
coli) 		PF01451
(LMWPc) 		4 LEU A  26
GLN A 133
LEU A 135
GLU A 136
 None
 1.05A 3h5gB-2wmyA:
undetectable
3h5gC-2wmyA:
undetectable		 3h5gB-2wmyA:
12.67
3h5gC-2wmyA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 LEU A  22
GLN A 175
LEU A 177
GLU A 178
 None
 1.09A 3h5gB-2ywbA:
undetectable
3h5gC-2ywbA:
undetectable		 3h5gB-2ywbA:
4.52
3h5gC-2ywbA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cit SENSOR HISTIDINE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 LEU A  65
GLN A  75
LEU A  66
GLU A  67
 None
 1.08A 3h5gB-3citA:
undetectable
3h5gC-3citA:
undetectable		 3h5gB-3citA:
11.39
3h5gC-3citA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daw TWINFILIN-1

(Mus musculus) 		PF00241
(Cofilin_ADF) 		4 LEU B 287
GLN B 188
LEU B 190
GLU B 191
 None
 0.65A 3h5gB-3dawB:
undetectable
3h5gC-3dawB:
undetectable		 3h5gB-3dawB:
12.74
3h5gC-3dawB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emu LEUCINE RICH REPEAT
AND PHOSPHATASE
DOMAIN CONTAINING
PROTEIN

(Entamoeba
histolytica) 		PF00782
(DSPc) 		4 LEU A 322
LYS A 426
GLN A 428
LEU A 430
 None
 1.10A 3h5gB-3emuA:
undetectable
3h5gC-3emuA:
undetectable		 3h5gB-3emuA:
11.80
3h5gC-3emuA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvb BACTERIOFERRITIN

(Brucella
abortus) 		PF00210
(Ferritin) 		4 LEU A  32
GLN A  24
LEU A  31
GLU A  44
 None
 0.95A 3h5gB-3fvbA:
undetectable
3h5gC-3fvbA:
undetectable		 3h5gB-3fvbA:
10.46
3h5gC-3fvbA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ism CG4930

(Drosophila
melanogaster) 		PF08785
(Ku_PK_bind) 		4 LYS C 134
GLN C  90
LEU C  92
GLU C  93
 None
 1.02A 3h5gB-3ismC:
undetectable
3h5gC-3ismC:
undetectable		 3h5gB-3ismC:
6.19
3h5gC-3ismC:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ism CG4930

(Drosophila
melanogaster) 		PF08785
(Ku_PK_bind) 		4 LYS C 134
LEU C 136
GLN C  90
GLU C  93
 None
 0.79A 3h5gB-3ismC:
undetectable
3h5gC-3ismC:
undetectable		 3h5gB-3ismC:
6.19
3h5gC-3ismC:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwz CATABOLITE
ACTIVATION-LIKE
PROTEIN

(Xanthomonas
campestris) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		4 LEU A 196
GLN A 191
LEU A 193
GLU A 192
 None
 1.12A 3h5gB-3iwzA:
undetectable
3h5gC-3iwzA:
undetectable		 3h5gB-3iwzA:
9.91
3h5gC-3iwzA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3A

(Saccharomyces
cerevisiae) 		PF00411
(Ribosomal_S11) 		4 LYS o 410
GLN o 403
LEU o 387
GLU o 386
 None
 1.10A 3h5gB-3japo:
undetectable
3h5gC-3japo:
undetectable		 3h5gB-3japo:
4.25
3h5gC-3japo:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhr ZINC FINGER PROTEIN
24

(Homo sapiens) 		PF02023
(SCAN) 		4 LYS A  45
GLN A  47
LEU A  49
GLU A  50
 None
None
EMC  A  97 (-3.5A)
EMC  A  97 (-4.0A)
 1.09A 3h5gB-3lhrA:
undetectable
3h5gC-3lhrA:
undetectable		 3h5gB-3lhrA:
17.78
3h5gC-3lhrA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 LYS A 178
LEU A 501
LEU A 536
GLU A 537
 None
 0.83A 3h5gB-3ngoA:
undetectable
3h5gC-3ngoA:
undetectable		 3h5gB-3ngoA:
8.47
3h5gC-3ngoA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		4 LEU A 322
GLN A 294
LEU A 296
GLU A 297
 None
 1.10A 3h5gB-3opbA:
undetectable
3h5gC-3opbA:
undetectable		 3h5gB-3opbA:
3.58
3h5gC-3opbA:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7m MALATE DEHYDROGENASE

(Francisella
tularensis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LYS A  25
LEU A  27
GLN A 241
GLU A 244
 None
 1.11A 3h5gB-3p7mA:
undetectable
3h5gC-3p7mA:
undetectable		 3h5gB-3p7mA:
7.58
3h5gC-3p7mA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnf LIDA

(Legionella
pneumophila) 		no annotation 4 LEU B 564
LYS B 218
LEU B 222
GLU B 223
 None
 0.86A 3h5gB-3tnfB:
undetectable
3h5gC-3tnfB:
undetectable		 3h5gB-3tnfB:
7.16
3h5gC-3tnfB:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u21 NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN

(Homo sapiens) 		PF14465
(NFRKB_winged) 		4 LEU A 461
GLN A 392
LEU A 460
GLU A 450
 None
MLY  A 459 ( 3.8A)
MLY  A 459 ( 4.2A)
MLY  A 452 ( 3.4A)
 1.06A 3h5gB-3u21A:
undetectable
3h5gC-3u21A:
undetectable		 3h5gB-3u21A:
14.17
3h5gC-3u21A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uo2 J-TYPE CO-CHAPERONE
JAC1, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00226
(DnaJ)
PF07743
(HSCB_C) 		4 LEU A 127
GLN A 117
LEU A 115
GLU A 114
 None
 1.11A 3h5gB-3uo2A:
undetectable
3h5gC-3uo2A:
undetectable		 3h5gB-3uo2A:
11.43
3h5gC-3uo2A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwq OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Vibrio cholerae) 		PF00215
(OMPdecase) 		4 LEU A 165
GLN A 137
LEU A 164
GLU A 161
 None
 0.94A 3h5gB-3uwqA:
undetectable
3h5gC-3uwqA:
undetectable		 3h5gB-3uwqA:
7.57
3h5gC-3uwqA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF16420
(ATG7_N) 		4 LEU A  28
GLN A  23
LEU A  25
GLU A  24
 None
 0.95A 3h5gB-3vh1A:
undetectable
3h5gC-3vh1A:
undetectable		 3h5gB-3vh1A:
4.18
3h5gC-3vh1A:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1

(Caenorhabditis
elegans) 		PF10250
(O-FucT) 		4 LYS A 285
GLN A 287
LEU A 289
GLU A 290
 None
 1.07A 3h5gB-3zy3A:
undetectable
3h5gC-3zy3A:
undetectable		 3h5gB-3zy3A:
6.69
3h5gC-3zy3A:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9w MONOOXYGENASE

(Stenotrophomonas
maltophilia) 		PF13738
(Pyr_redox_3) 		4 LEU A  16
LYS A  88
GLN A  87
GLU A  86
 None
 1.04A 3h5gB-4a9wA:
undetectable
3h5gC-4a9wA:
undetectable		 3h5gB-4a9wA:
6.46
3h5gC-4a9wA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5m PUTATIVE
EXODEOXYRIBONUCLEASE

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		4 LYS A 185
LEU A 186
LEU A 134
GLU A 135
 None
 1.11A 3h5gB-4b5mA:
undetectable
3h5gC-4b5mA:
undetectable		 3h5gB-4b5mA:
6.56
3h5gC-4b5mA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 LEU A1540
GLN A1419
LEU A1408
GLU A1409
 None
 1.08A 3h5gB-4bedA:
undetectable
3h5gC-4bedA:
undetectable		 3h5gB-4bedA:
2.24
3h5gC-4bedA:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfc 3-DEOXY-D-MANNO-OCTU
LOSONIC-ACID
TRANSFERASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A 289
GLN A 252
LEU A 254
GLU A 255
 None
 1.04A 3h5gB-4bfcA:
undetectable
3h5gC-4bfcA:
undetectable		 3h5gB-4bfcA:
7.96
3h5gC-4bfcA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebr UBIQUITIN-LIKE-CONJU
GATING ENZYME ATG10

(Saccharomyces
cerevisiae) 		PF03987
(Autophagy_act_C) 		4 LEU A  39
GLN A  27
LEU A  40
GLU A  64
 None
 1.12A 3h5gB-4ebrA:
undetectable
3h5gC-4ebrA:
undetectable		 3h5gB-4ebrA:
13.25
3h5gC-4ebrA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 LEU C 237
GLN C 199
LEU C 201
GLU C 202
 None
 0.97A 3h5gB-4hb4C:
undetectable
3h5gC-4hb4C:
undetectable		 3h5gB-4hb4C:
2.58
3h5gC-4hb4C:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		4 LEU A 204
LYS A 165
LEU A 169
GLU A 170
 None
 0.84A 3h5gB-4jeuA:
undetectable
3h5gC-4jeuA:
undetectable		 3h5gB-4jeuA:
7.55
3h5gC-4jeuA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6y PROTEIN REGULATOR OF
CYTOKINESIS 1

(Homo sapiens) 		PF03999
(MAP65_ASE1) 		4 LEU A 124
GLN A 119
LEU A 121
GLU A 120
 None
 1.05A 3h5gB-4l6yA:
undetectable
3h5gC-4l6yA:
undetectable		 3h5gB-4l6yA:
6.74
3h5gC-4l6yA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 LEU A 537
GLN A 592
LEU A 594
GLU A 595
 None
 0.97A 3h5gB-4nmeA:
undetectable
3h5gC-4nmeA:
undetectable		 3h5gB-4nmeA:
2.76
3h5gC-4nmeA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqq CADHERIN-3

(Mus musculus) 		PF00028
(Cadherin) 		4 LEU A  61
GLN A  23
LEU A  60
GLU A  54
 None
 0.99A 3h5gB-4nqqA:
undetectable
3h5gC-4nqqA:
undetectable		 3h5gB-4nqqA:
10.53
3h5gC-4nqqA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 LEU B 406
GLN B 413
LEU B 411
GLU B 410
 None
PG4  B 503 (-3.5A)
None
None
 1.13A 3h5gB-4ov6B:
undetectable
3h5gC-4ov6B:
undetectable		 3h5gB-4ov6B:
6.12
3h5gC-4ov6B:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		4 LYS A 459
LEU A 460
LYS A 377
GLU A 382
 None
 1.04A 3h5gB-4pe2A:
undetectable
3h5gC-4pe2A:
undetectable		 3h5gB-4pe2A:
4.46
3h5gC-4pe2A:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzl ADENYLATE KINASE

(Francisella
tularensis) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 LEU A  99
GLN A  94
LEU A  96
GLU A  95
 None
 1.11A 3h5gB-4pzlA:
undetectable
3h5gC-4pzlA:
undetectable		 3h5gB-4pzlA:
10.22
3h5gC-4pzlA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5r GLUTATHIONE
S-TRANSFERASE

(Blattella
germanica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LYS A  28
LEU A  23
GLN A  75
LEU A  22
 None
 1.13A 3h5gB-4q5rA:
undetectable
3h5gC-4q5rA:
undetectable		 3h5gB-4q5rA:
10.05
3h5gC-4q5rA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4k UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		no annotation 4 LEU A 161
GLN A 168
LEU A 166
GLU A 165
 None
 1.04A 3h5gB-4r4kA:
undetectable
3h5gC-4r4kA:
undetectable		 3h5gB-4r4kA:
12.99
3h5gC-4r4kA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tko EMRA

(Aquifex
aeolicus) 		PF13437
(HlyD_3)
PF13533
(Biotin_lipoyl_2) 		4 LYS B 104
GLN B 106
LEU B 108
GLU B 109
 None
 0.58A 3h5gB-4tkoB:
undetectable
3h5gC-4tkoB:
undetectable		 3h5gB-4tkoB:
6.42
3h5gC-4tkoB:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		4 LEU B 700
GLN B 696
LEU B 581
GLU B 582
 None
 1.02A 3h5gB-4wvmB:
undetectable
3h5gC-4wvmB:
undetectable		 3h5gB-4wvmB:
3.30
3h5gC-4wvmB:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28

(Cytomegalovirus) 		PF00001
(7tm_1) 		4 LEU A 305
GLN A 300
LEU A 302
GLU A 301
 None
 1.12A 3h5gB-4xt1A:
undetectable
3h5gC-4xt1A:
undetectable		 3h5gB-4xt1A:
7.24
3h5gC-4xt1A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z07 CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 LYS A 197
LYS A 167
LEU A 172
GLU A 164
 None
PCG  A 401 ( 4.5A)
PCG  A 401 (-3.9A)
None
 1.13A 3h5gB-4z07A:
undetectable
3h5gC-4z07A:
undetectable		 3h5gB-4z07A:
8.27
3h5gC-4z07A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmx CADHERIN-3

(Homo sapiens) 		PF00028
(Cadherin) 		4 LEU A  61
GLN A  23
LEU A  60
GLU A  54
 None
 0.84A 3h5gB-4zmxA:
undetectable
3h5gC-4zmxA:
undetectable		 3h5gB-4zmxA:
10.53
3h5gC-4zmxA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zry KERATIN, TYPE I
CYTOSKELETAL 10
KERATIN, TYPE II
CYTOSKELETAL 1

(Homo sapiens;
Homo sapiens) 		PF00038
(Filament)
PF00038
(Filament)
PF11839
(Alanine_zipper) 		4 LEU B 422
GLN A 387
LEU A 389
GLU A 390
 None
 1.02A 3h5gB-4zryB:
undetectable
3h5gC-4zryB:
undetectable		 3h5gB-4zryB:
15.00
3h5gC-4zryB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 4 LYS A 678
GLN A 680
LEU A 682
GLU A 683
 None
 0.83A 3h5gB-4zuzA:
undetectable
3h5gC-4zuzA:
undetectable		 3h5gB-4zuzA:
2.95
3h5gC-4zuzA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch6 FRIGIDA

(Vitis vinifera) 		PF07899
(Frigida) 		5 LYS A 351
LEU A 347
LYS A 376
LEU A 380
GLU A 381
 None
 1.30A 3h5gB-5ch6A:
undetectable
3h5gC-5ch6A:
undetectable		 3h5gB-5ch6A:
8.30
3h5gC-5ch6A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czj DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 LEU A 243
GLN A 266
LEU A 268
GLU A 265
 None
 1.09A 3h5gB-5czjA:
undetectable
3h5gC-5czjA:
undetectable		 3h5gB-5czjA:
7.21
3h5gC-5czjA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 LEU A 435
GLN A 408
LEU A 410
GLU A 411
 None
 1.00A 3h5gB-5ddsA:
undetectable
3h5gC-5ddsA:
undetectable		 3h5gB-5ddsA:
5.02
3h5gC-5ddsA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzz DESMOPLAKIN

(Homo sapiens) 		PF00681
(Plectin) 		4 LYS A1999
LEU A1994
LYS A1988
LEU A1991
 None
 1.12A 3h5gB-5dzzA:
undetectable
3h5gC-5dzzA:
undetectable		 3h5gB-5dzzA:
5.35
3h5gC-5dzzA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 839
GLN A 639
LEU A 641
GLU A 637
 None
 1.04A 3h5gB-5grnA:
undetectable
3h5gC-5grnA:
undetectable		 3h5gB-5grnA:
6.18
3h5gC-5grnA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 LEU A  70
GLN A  66
LEU A  68
GLU A  65
 None
 1.05A 3h5gB-5gtmA:
undetectable
3h5gC-5gtmA:
undetectable		 3h5gB-5gtmA:
5.35
3h5gC-5gtmA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		4 LEU A 238
GLN A 243
LEU A 239
GLU A 242
 None
None
None
CL  A 306 ( 4.5A)
 0.75A 3h5gB-5i1fA:
undetectable
3h5gC-5i1fA:
undetectable		 3h5gB-5i1fA:
7.28
3h5gC-5i1fA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU A 522
GLN A 600
LEU A 547
GLU A 546
 None
 1.11A 3h5gB-5ijbA:
undetectable
3h5gC-5ijbA:
undetectable		 3h5gB-5ijbA:
4.16
3h5gC-5ijbA:
4.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Paraburkholderia
xenovorans) 		PF00483
(NTP_transferase) 		4 LEU A 238
GLN A 243
LEU A 239
GLU A 242
 None
 0.73A 3h5gB-5j49A:
undetectable
3h5gC-5j49A:
undetectable		 3h5gB-5j49A:
8.85
3h5gC-5j49A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9w CHROMATIN
MODIFICATION-RELATED
PROTEIN YNG2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU H  35
LYS H  78
GLN H  80
LEU H  82
 None
 0.99A 3h5gB-5j9wH:
undetectable
3h5gC-5j9wH:
undetectable		 3h5gB-5j9wH:
17.24
3h5gC-5j9wH:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyl CADHERIN-3

(Homo sapiens) 		PF00028
(Cadherin) 		4 LEU A  61
GLN A  23
LEU A  60
GLU A  54
 None
 0.88A 3h5gB-5jylA:
undetectable
3h5gC-5jylA:
undetectable		 3h5gB-5jylA:
19.54
3h5gC-5jylA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Trichormus
variabilis) 		PF00701
(DHDPS) 		4 LEU A 261
GLN A 282
LEU A 284
GLU A 285
 None
 0.92A 3h5gB-5ktlA:
undetectable
3h5gC-5ktlA:
undetectable		 3h5gB-5ktlA:
5.79
3h5gC-5ktlA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvr PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR

(Escherichia
coli) 		PF00392
(GntR) 		4 LEU A  63
GLN A  17
LEU A  19
GLU A  20
 None
 1.04A 3h5gB-5kvrA:
undetectable
3h5gC-5kvrA:
undetectable		 3h5gB-5kvrA:
19.44
3h5gC-5kvrA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 LYS A 507
GLN A 509
LEU A 511
GLU A 512
 None
 0.82A 3h5gB-5l3dA:
undetectable
3h5gC-5l3dA:
undetectable		 3h5gB-5l3dA:
3.56
3h5gC-5l3dA:
3.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		no annotation 4 LEU B4008
GLN B4003
LEU B4005
GLU B4004
 None
 1.10A 3h5gB-5lp8B:
undetectable
3h5gC-5lp8B:
undetectable		 3h5gB-5lp8B:
5.79
3h5gC-5lp8B:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A 350
GLN A 332
LEU A 334
GLU A 331
 None
 1.09A 3h5gB-5m5pA:
undetectable
3h5gC-5m5pA:
undetectable		 3h5gB-5m5pA:
2.89
3h5gC-5m5pA:
2.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgt KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY B MEMBER 1

(Homo sapiens) 		no annotation 4 LEU C 144
LYS C 104
GLN C 100
LEU C 106
 None
 0.87A 3h5gB-5mgtC:
undetectable
3h5gC-5mgtC:
undetectable		 3h5gB-5mgtC:
undetectable
3h5gC-5mgtC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		4 LEU A 547
GLN A 509
LEU A 513
GLU A 511
 None
 1.00A 3h5gB-5n8oA:
undetectable
3h5gC-5n8oA:
undetectable		 3h5gB-5n8oA:
1.59
3h5gC-5n8oA:
1.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7

(Saccharomyces
cerevisiae) 		PF05983
(Med7) 		4 LEU U 122
GLN U 117
LEU U 119
GLU U 118
 None
 1.11A 3h5gB-5svaU:
undetectable
3h5gC-5svaU:
undetectable		 3h5gB-5svaU:
9.81
3h5gC-5svaU:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdy FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima) 		PF14842
(FliG_N) 		4 LYS B  54
GLN B  56
LEU B  58
GLU B  59
 None
 1.04A 3h5gB-5tdyB:
undetectable
3h5gC-5tdyB:
undetectable		 3h5gB-5tdyB:
19.35
3h5gC-5tdyB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 4 LYS A  69
LEU A  72
GLN A  97
LEU A  95
 None
 1.10A 3h5gB-5u30A:
undetectable
3h5gC-5u30A:
undetectable		 3h5gB-5u30A:
3.07
3h5gC-5u30A:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unq PUTATIVE TAUTOMERASE

(Pusillimonas
sp. T7-7) 		no annotation 4 LYS A  16
GLN A  18
LEU A  20
GLU A  21
 None
 1.12A 3h5gB-5unqA:
undetectable
3h5gC-5unqA:
undetectable		 3h5gB-5unqA:
13.01
3h5gC-5unqA:
13.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uxt COILED-COIL TRIMER
WITH GLU:TRP:LYS
TRIAD

(synthetic
construct) 		no annotation 4 LYS A  15
GLN A  17
LEU A  19
GLU A  20
 None
 1.06A 3h5gB-5uxtA:
undetectable
3h5gC-5uxtA:
undetectable		 3h5gB-5uxtA:
77.42
3h5gC-5uxtA:
77.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN

(Lama glama;
Human
betaherpesvirus
5) 		no annotation 4 LEU A 305
GLN A 300
LEU A 302
GLU A 301
 None
 1.09A 3h5gB-5wb1A:
undetectable
3h5gC-5wb1A:
undetectable		 3h5gB-5wb1A:
undetectable
3h5gC-5wb1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv5 CONSERVED PROTEIN

(Methanosarcina
mazei) 		no annotation 4 LYS A 130
LYS A 118
LEU A 122
GLU A 123
 None
 1.12A 3h5gB-5xv5A:
undetectable
3h5gC-5xv5A:
undetectable		 3h5gB-5xv5A:
undetectable
3h5gC-5xv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 4 LEU A 341
GLN A 304
LEU A 306
GLU A 303
 None
 1.04A 3h5gB-5xxgA:
undetectable
3h5gC-5xxgA:
undetectable		 3h5gB-5xxgA:
undetectable
3h5gC-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4j NUCLEOPORIN LIKE 2

(Homo sapiens) 		no annotation 4 LEU C 393
GLN C 400
LEU C 398
GLU C 397
 None
 1.01A 3h5gB-6b4jC:
undetectable
3h5gC-6b4jC:
undetectable		 3h5gB-6b4jC:
undetectable
3h5gC-6b4jC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 LEU A1038
GLN A1129
LEU A1127
GLU A1126
 None
 0.92A 3h5gB-6fikA:
undetectable
3h5gC-6fikA:
undetectable		 3h5gB-6fikA:
undetectable
3h5gC-6fikA:
undetectable