SIMILAR PATTERNS OF AMINO ACIDS FOR 3H5G_B_LEIB16

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5) 		4 LEU A 456
GLN A 403
LEU A 405
GLU A 401
 None
TPT  A 480 (-4.0A)
None
None
 1.15A 3h5gA-1b7eA:
undetectable
3h5gB-1b7eA:
undetectable		 3h5gA-1b7eA:
7.10
3h5gB-1b7eA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7s GDP-FUCOSE
SYNTHETASE

(Escherichia
coli) 		PF01370
(Epimerase) 		4 LEU A 301
GLN A 258
LEU A 256
GLU A 255
 None
 0.82A 3h5gA-1e7sA:
undetectable
3h5gB-1e7sA:
undetectable		 3h5gA-1e7sA:
6.31
3h5gB-1e7sA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evs ONCOSTATIN M

(Homo sapiens) 		PF01291
(LIF_OSM) 		4 LEU A  85
GLN A  90
LEU A  88
GLU A  89
 None
 1.08A 3h5gA-1evsA:
undetectable
3h5gB-1evsA:
undetectable		 3h5gA-1evsA:
11.56
3h5gB-1evsA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gjj LAP2

(Homo sapiens) 		PF03020
(LEM)
PF08198
(Thymopoietin) 		4 LEU A  40
GLN A  32
LEU A  27
GLU A  31
 None
 0.89A 3h5gA-1gjjA:
undetectable
3h5gB-1gjjA:
undetectable		 3h5gA-1gjjA:
12.90
3h5gB-1gjjA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijx SECRETED
FRIZZLED-RELATED
SEQUENCE PROTEIN 3

(Mus musculus) 		PF01392
(Fz) 		4 LEU A  10
GLN A  39
LEU A  44
GLU A  41
 None
 1.10A 3h5gA-1ijxA:
undetectable
3h5gB-1ijxA:
undetectable		 3h5gA-1ijxA:
10.24
3h5gB-1ijxA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbz DTDP-GLUCOSE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF04321
(RmlD_sub_bind) 		4 LEU A 246
GLN A 174
LEU A 176
GLU A 245
 None
 0.93A 3h5gA-1kbzA:
undetectable
3h5gB-1kbzA:
undetectable		 3h5gA-1kbzA:
7.69
3h5gB-1kbzA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvg GUANYLATE KINASE

(Mus musculus) 		PF00625
(Guanylate_kin) 		4 LEU A 149
GLN A 132
LEU A 134
GLU A 131
 None
 1.16A 3h5gA-1lvgA:
undetectable
3h5gB-1lvgA:
undetectable		 3h5gA-1lvgA:
12.20
3h5gB-1lvgA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Gallus gallus;
Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 LEU C 124
LYS B 183
GLN B 185
LEU B 187
 None
 0.86A 3h5gA-1m1jC:
undetectable
3h5gB-1m1jC:
undetectable		 3h5gA-1m1jC:
7.64
3h5gB-1m1jC:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3k ASTROCYTIC
PHOSPHOPROTEIN
PEA-15

(Cricetulus
griseus) 		PF01335
(DED) 		4 LEU A  17
GLN A  22
LEU A  20
GLU A  21
 None
 1.13A 3h5gA-1n3kA:
undetectable
3h5gB-1n3kA:
undetectable		 3h5gA-1n3kA:
12.31
3h5gB-1n3kA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puf HOMEOBOX PROTEIN
HOX-A9

(Mus musculus) 		PF00046
(Homeobox) 		4 LYS A 214
GLN A 216
LEU A 218
GLU A 219
 None
 0.85A 3h5gA-1pufA:
undetectable
3h5gB-1pufA:
undetectable		 3h5gA-1pufA:
12.99
3h5gB-1pufA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		4 LEU A 108
GLN A 113
LEU A 111
GLU A 112
 None
 1.08A 3h5gA-1tf1A:
undetectable
3h5gB-1tf1A:
undetectable		 3h5gA-1tf1A:
13.74
3h5gB-1tf1A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdz INSULIN RECEPTOR
SUBSTRATE P53

(Homo sapiens) 		PF08397
(IMD) 		4 LEU A 102
GLN A 107
LEU A 105
GLU A 106
 None
 1.10A 3h5gA-1wdzA:
undetectable
3h5gB-1wdzA:
undetectable		 3h5gA-1wdzA:
10.30
3h5gB-1wdzA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 399
GLN A 358
LEU A 360
GLU A 361
 None
 1.01A 3h5gA-1y4uA:
undetectable
3h5gB-1y4uA:
undetectable		 3h5gA-1y4uA:
4.47
3h5gB-1y4uA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yix DEOXYRIBONUCLEASE
YCFH

(Escherichia
coli) 		PF01026
(TatD_DNase) 		4 LEU A 197
GLN A 244
LEU A 242
GLU A 241
 None
 1.04A 3h5gA-1yixA:
undetectable
3h5gB-1yixA:
undetectable		 3h5gA-1yixA:
9.76
3h5gB-1yixA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 976
GLN A 818
LEU A 820
GLU A 821
 None
 1.11A 3h5gA-1zy4A:
undetectable
3h5gB-1zy4A:
undetectable		 3h5gA-1zy4A:
7.26
3h5gB-1zy4A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		4 LEU A  10
GLN A  14
LEU A  12
GLU A  13
 None
 0.99A 3h5gA-2a9fA:
undetectable
3h5gB-2a9fA:
undetectable		 3h5gA-2a9fA:
7.54
3h5gB-2a9fA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avx REGULATORY PROTEIN
SDIA

(Escherichia
coli) 		PF03472
(Autoind_bind) 		4 LEU A 133
LYS A 153
GLN A 155
LEU A 157
 None
 0.92A 3h5gA-2avxA:
undetectable
3h5gB-2avxA:
undetectable		 3h5gA-2avxA:
9.47
3h5gB-2avxA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 LEU A 194
GLN A 190
LEU A 277
GLU A 278
 None
 1.12A 3h5gA-2c11A:
undetectable
3h5gB-2c11A:
undetectable		 3h5gA-2c11A:
3.42
3h5gB-2c11A:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		4 LEU A 510
GLN A 478
LEU A 488
GLU A 511
 None
 1.15A 3h5gA-2dh3A:
undetectable
3h5gB-2dh3A:
undetectable		 3h5gA-2dh3A:
6.89
3h5gB-2dh3A:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		4 LEU A 113
LYS A 208
GLN A 210
LEU A 212
 None
 1.16A 3h5gA-2h1yA:
undetectable
3h5gB-2h1yA:
undetectable		 3h5gA-2h1yA:
7.17
3h5gB-2h1yA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmc DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 LEU A 223
GLN A 246
LEU A 248
GLU A 245
 None
 1.06A 3h5gA-2hmcA:
undetectable
3h5gB-2hmcA:
undetectable		 3h5gA-2hmcA:
6.10
3h5gB-2hmcA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 LEU A  59
LYS A  53
GLN A  54
GLU A  58
 None
 1.08A 3h5gA-2i00A:
undetectable
3h5gB-2i00A:
undetectable		 3h5gA-2i00A:
7.21
3h5gB-2i00A:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3f GLYCOLIPID
TRANSFER-LIKE
PROTEIN

(Galdieria
sulphuraria) 		PF08718
(GLTP) 		4 LEU A  36
LYS A  66
GLN A  72
LEU A  67
 None
 1.00A 3h5gA-2i3fA:
undetectable
3h5gB-2i3fA:
undetectable		 3h5gA-2i3fA:
8.87
3h5gB-2i3fA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 196
LYS A 189
GLN A 190
LEU A 192
 None
 1.13A 3h5gA-2ibdA:
undetectable
3h5gB-2ibdA:
undetectable		 3h5gA-2ibdA:
12.93
3h5gB-2ibdA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifu GAMMA-SNAP

(Danio rerio) 		PF14938
(SNAP) 		4 LEU A  87
LYS A  48
LEU A  50
GLU A  51
 None
 1.04A 3h5gA-2ifuA:
undetectable
3h5gB-2ifuA:
undetectable		 3h5gA-2ifuA:
7.54
3h5gB-2ifuA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 399
GLN A 358
LEU A 360
GLU A 361
 None
 1.05A 3h5gA-2iopA:
undetectable
3h5gB-2iopA:
undetectable		 3h5gA-2iopA:
4.28
3h5gB-2iopA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lp0 HOMEOBOX PROTEIN
HOX-C9

(Homo sapiens) 		PF00046
(Homeobox) 		4 LYS A  26
GLN A  28
LEU A  30
GLU A  31
 None
 0.99A 3h5gA-2lp0A:
undetectable
3h5gB-2lp0A:
undetectable		 3h5gA-2lp0A:
13.64
3h5gB-2lp0A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ls7 ASTROCYTIC
PHOSPHOPROTEIN
PEA-15

(Mus musculus) 		PF01335
(DED) 		4 LEU A  17
GLN A  22
LEU A  20
GLU A  21
 None
 1.06A 3h5gA-2ls7A:
undetectable
3h5gB-2ls7A:
undetectable		 3h5gA-2ls7A:
14.13
3h5gB-2ls7A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		4 LEU A 222
LYS A 282
GLN A 284
LEU A 286
 None
 1.03A 3h5gA-2nuxA:
undetectable
3h5gB-2nuxA:
undetectable		 3h5gA-2nuxA:
7.99
3h5gB-2nuxA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl5 HOMOSERINE
O-ACETYLTRANSFERASE

(Leptospira
interrogans) 		PF00561
(Abhydrolase_1) 		4 LEU A 286
GLN A 158
LEU A 160
GLU A 161
 None
 0.89A 3h5gA-2pl5A:
undetectable
3h5gB-2pl5A:
undetectable		 3h5gA-2pl5A:
6.28
3h5gB-2pl5A:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		4 LEU A 331
LYS A 371
GLN A 373
LEU A 326
 None
 0.94A 3h5gA-2qzaA:
undetectable
3h5gB-2qzaA:
undetectable		 3h5gA-2qzaA:
4.12
3h5gB-2qzaA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 LEU A 202
LYS A 212
GLN A 259
LEU A 213
 None
 1.13A 3h5gA-2rkoA:
undetectable
3h5gB-2rkoA:
undetectable		 3h5gA-2rkoA:
6.65
3h5gB-2rkoA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 155
GLN A 326
LEU A 324
GLU A 298
 None
 1.12A 3h5gA-2rsvA:
undetectable
3h5gB-2rsvA:
undetectable		 3h5gA-2rsvA:
6.76
3h5gB-2rsvA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
KINETOCHORE PROTEIN
NUF2, KINETOCHORE
PROTEIN SPC24

(Homo sapiens;
Homo sapiens) 		PF03801
(Ndc80_HEC)
PF08234
(Spindle_Spc25)
PF03800
(Nuf2)
PF08286
(Spc24) 		4 LEU C 155
LYS A 264
LEU A 268
GLU A 269
 None
 1.14A 3h5gA-2ve7C:
undetectable
3h5gB-2ve7C:
undetectable		 3h5gA-2ve7C:
9.55
3h5gB-2ve7C:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voa EXODEOXYRIBONUCLEASE
III

(Archaeoglobus
fulgidus) 		PF03372
(Exo_endo_phos) 		4 LYS A 120
GLN A 122
LEU A 124
GLU A 125
 OCS  A 167 ( 3.0A)
None
None
None
 0.85A 3h5gA-2voaA:
undetectable
3h5gB-2voaA:
undetectable		 3h5gA-2voaA:
9.39
3h5gB-2voaA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 LEU A2056
LYS A1118
GLN A2059
LEU A2106
 None
 1.12A 3h5gA-2vz9A:
undetectable
3h5gB-2vz9A:
undetectable		 3h5gA-2vz9A:
1.19
3h5gB-2vz9A:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 LEU A 133
LYS A  68
GLN A  70
LEU A  72
 None
 1.11A 3h5gA-2wnwA:
undetectable
3h5gB-2wnwA:
undetectable		 3h5gA-2wnwA:
6.03
3h5gB-2wnwA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 LEU A 199
GLN A  83
LEU A  81
GLU A  85
 None
 1.10A 3h5gA-2wyxA:
undetectable
3h5gB-2wyxA:
undetectable		 3h5gA-2wyxA:
12.50
3h5gB-2wyxA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x77 ADP-RIBOSYLATION
FACTOR

(Leishmania
major) 		PF00025
(Arf) 		4 LEU A  15
LYS A   9
GLN A  10
LEU A  12
 None
 1.09A 3h5gA-2x77A:
undetectable
3h5gB-2x77A:
undetectable		 3h5gA-2x77A:
8.99
3h5gB-2x77A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1

(Homo sapiens) 		PF01026
(TatD_DNase) 		4 LEU A  93
GLN A 141
LEU A 138
GLU A 137
 None
 1.12A 3h5gA-2xioA:
undetectable
3h5gB-2xioA:
undetectable		 3h5gA-2xioA:
7.64
3h5gB-2xioA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		4 LEU A 221
GLN A 289
LEU A 287
GLU A 286
 None
 0.93A 3h5gA-2ychA:
undetectable
3h5gB-2ychA:
undetectable		 3h5gA-2ychA:
7.07
3h5gB-2ychA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 LEU A  22
GLN A 175
LEU A 177
GLU A 178
 None
 1.00A 3h5gA-2ywbA:
undetectable
3h5gB-2ywbA:
undetectable		 3h5gA-2ywbA:
4.52
3h5gB-2ywbA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 267
GLN A 119
LEU A 121
GLU A 122
 None
 1.08A 3h5gA-3bhhA:
undetectable
3h5gB-3bhhA:
undetectable		 3h5gA-3bhhA:
7.46
3h5gB-3bhhA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans) 		PF12697
(Abhydrolase_6) 		4 LEU A 113
GLN A  84
LEU A  86
GLU A  87
 None
 0.86A 3h5gA-3bwxA:
undetectable
3h5gB-3bwxA:
undetectable		 3h5gA-3bwxA:
7.50
3h5gB-3bwxA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbg O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF01596
(Methyltransf_3) 		4 LEU A 134
GLN A  63
LEU A 159
GLU A 136
 None
 1.06A 3h5gA-3cbgA:
undetectable
3h5gB-3cbgA:
undetectable		 3h5gA-3cbgA:
10.11
3h5gB-3cbgA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 LEU A 502
LYS A 538
LEU A 534
GLU A 533
 None
 1.16A 3h5gA-3cemA:
undetectable
3h5gB-3cemA:
undetectable		 3h5gA-3cemA:
3.09
3h5gB-3cemA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cje OSMC-LIKE PROTEIN

(Jannaschia sp.
CCS1) 		PF02566
(OsmC) 		4 LEU A  69
GLN A  76
LEU A 143
GLU A 144
 None
 1.02A 3h5gA-3cjeA:
undetectable
3h5gB-3cjeA:
undetectable		 3h5gA-3cjeA:
12.35
3h5gB-3cjeA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		4 LEU A 150
GLN A  50
LEU A  48
GLU A  47
 None
 1.13A 3h5gA-3d8nA:
undetectable
3h5gB-3d8nA:
undetectable		 3h5gA-3d8nA:
9.27
3h5gB-3d8nA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh MUKE

(Escherichia
coli) 		PF04288
(MukE) 		4 LEU C 111
GLN C 127
LEU C 129
GLU C 128
 None
 1.14A 3h5gA-3euhC:
undetectable
3h5gB-3euhC:
undetectable		 3h5gA-3euhC:
8.19
3h5gB-3euhC:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 353
LYS A 320
GLN A 322
LEU A 324
 None
 1.14A 3h5gA-3fhtA:
undetectable
3h5gB-3fhtA:
undetectable		 3h5gA-3fhtA:
6.07
3h5gB-3fhtA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi1 NA(+)/H(+)
ANTIPORTER NHAA

(Escherichia
coli) 		PF06965
(Na_H_antiport_1) 		4 LEU A  88
GLN A  85
LEU A  83
GLU A  82
 None
 0.97A 3h5gA-3fi1A:
undetectable
3h5gB-3fi1A:
undetectable		 3h5gA-3fi1A:
8.02
3h5gB-3fi1A:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 104
LYS A  76
LEU A  72
GLU A  71
 NIL  A   1 ( 4.3A)
None
None
NIL  A   1 (-3.7A)
 1.12A 3h5gA-3gp0A:
undetectable
3h5gB-3gp0A:
undetectable		 3h5gA-3gp0A:
7.54
3h5gB-3gp0A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqm CELL INHIBITING
FACTOR (CIFBP)

(Burkholderia
pseudomallei) 		PF16374
(CIF) 		4 LEU A  48
GLN A 250
LEU A 100
GLU A 103
 None
 1.02A 3h5gA-3gqmA:
undetectable
3h5gB-3gqmA:
undetectable		 3h5gA-3gqmA:
8.00
3h5gB-3gqmA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4t DIPHTHINE SYNTHASE

(Entamoeba
histolytica) 		PF00590
(TP_methylase) 		4 LEU A 237
GLN A 196
LEU A 198
GLU A 195
 None
 1.12A 3h5gA-3i4tA:
undetectable
3h5gB-3i4tA:
undetectable		 3h5gA-3i4tA:
6.94
3h5gB-3i4tA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5z FEM-3 MRNA-BINDING
FACTOR 2

(Caenorhabditis
elegans) 		PF00806
(PUF) 		4 LEU A 246
GLN A 205
LEU A 207
GLU A 208
 None
None
None
A  B   9 ( 4.4A)
 0.85A 3h5gA-3k5zA:
undetectable
3h5gB-3k5zA:
undetectable		 3h5gA-3k5zA:
6.91
3h5gB-3k5zA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhr ZINC FINGER PROTEIN
24

(Homo sapiens) 		PF02023
(SCAN) 		4 LYS A  45
GLN A  47
LEU A  49
GLU A  50
 None
None
EMC  A  97 (-3.5A)
EMC  A  97 (-4.0A)
 0.90A 3h5gA-3lhrA:
undetectable
3h5gB-3lhrA:
undetectable		 3h5gA-3lhrA:
17.78
3h5gB-3lhrA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5u PHOSPHOSERINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00266
(Aminotran_5) 		4 LEU A  15
GLN A  20
LEU A  18
GLU A  19
 None
 1.11A 3h5gA-3m5uA:
undetectable
3h5gB-3m5uA:
undetectable		 3h5gA-3m5uA:
7.48
3h5gB-3m5uA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 LEU A1003
GLN A 944
LEU A 942
GLU A 941
 None
 1.10A 3h5gA-3mpxA:
undetectable
3h5gB-3mpxA:
undetectable		 3h5gA-3mpxA:
6.67
3h5gB-3mpxA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 LEU A 433
GLN A 423
LEU A 425
GLU A 426
 None
 1.06A 3h5gA-3ozxA:
undetectable
3h5gB-3ozxA:
undetectable		 3h5gA-3ozxA:
4.46
3h5gB-3ozxA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 286
LYS A 303
GLN A 305
LEU A 304
 None
 1.13A 3h5gA-3s9vA:
undetectable
3h5gB-3s9vA:
undetectable		 3h5gA-3s9vA:
3.09
3h5gB-3s9vA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER

(Homo sapiens) 		PF00069
(Pkinase)
PF08332
(CaMKII_AD) 		4 LEU A 266
GLN A 118
LEU A 120
GLU A 121
 None
 1.03A 3h5gA-3soaA:
undetectable
3h5gB-3soaA:
undetectable		 3h5gA-3soaA:
5.43
3h5gB-3soaA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uo2 J-TYPE CO-CHAPERONE
JAC1, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00226
(DnaJ)
PF07743
(HSCB_C) 		4 LEU A 127
GLN A 117
LEU A 115
GLU A 114
 None
 0.96A 3h5gA-3uo2A:
undetectable
3h5gB-3uo2A:
undetectable		 3h5gA-3uo2A:
11.43
3h5gB-3uo2A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN

(Gallus gallus) 		PF00106
(adh_short) 		4 LEU A  54
GLN A  49
LEU A  51
GLU A  50
 None
 1.15A 3h5gA-3wxbA:
undetectable
3h5gB-3wxbA:
undetectable		 3h5gA-3wxbA:
9.95
3h5gB-3wxbA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PYRIDOXINE
BIOSYNTHETIC ENZYME
PDX1 HOMOLOGUE,
PUTATIVE

(Plasmodium
berghei) 		PF01680
(SOR_SNZ) 		4 LEU A 104
GLN A  94
LEU A  96
GLU A  97
 None
 1.05A 3h5gA-4adsA:
undetectable
3h5gB-4adsA:
undetectable		 3h5gA-4adsA:
7.89
3h5gB-4adsA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 289
GLN A 140
LEU A 142
GLU A 143
 None
 1.09A 3h5gA-4bc6A:
undetectable
3h5gB-4bc6A:
undetectable		 3h5gA-4bc6A:
8.19
3h5gB-4bc6A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chu HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ISCR

(Escherichia
coli) 		PF02082
(Rrf2) 		4 LEU A  39
GLN A  44
LEU A  42
GLU A  43
 None
 1.05A 3h5gA-4chuA:
undetectable
3h5gB-4chuA:
undetectable		 3h5gA-4chuA:
9.20
3h5gB-4chuA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ciu CHAPERONE PROTEIN
CLPB

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 LEU A 509
GLN A 481
LEU A 479
GLU A 478
 None
 1.13A 3h5gA-4ciuA:
undetectable
3h5gB-4ciuA:
undetectable		 3h5gA-4ciuA:
3.30
3h5gB-4ciuA:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dci UNCHARACTERIZED
PROTEIN

(Synechococcus
sp. WH 8102) 		PF11068
(YlqD) 		4 LEU A  42
LYS A  82
LEU A  86
GLU A  87
 None
 1.10A 3h5gA-4dciA:
undetectable
3h5gB-4dciA:
undetectable		 3h5gA-4dciA:
13.99
3h5gB-4dciA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyv FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00621
(RhoGEF) 		4 LEU A 547
GLN A 602
LEU A 604
GLU A 601
 None
 1.11A 3h5gA-4gyvA:
undetectable
3h5gB-4gyvA:
undetectable		 3h5gA-4gyvA:
10.55
3h5gB-4gyvA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbx UNCHARACTERIZED
PROTEIN YHFX

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 LEU A  45
GLN A  37
LEU A 259
GLU A 273
 None
 1.12A 3h5gA-4kbxA:
undetectable
3h5gB-4kbxA:
undetectable		 3h5gA-4kbxA:
5.93
3h5gB-4kbxA:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ki9 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
12

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A  28
LYS A 144
GLN A 146
LEU A 148
 None
 0.90A 3h5gA-4ki9A:
undetectable
3h5gB-4ki9A:
undetectable		 3h5gA-4ki9A:
11.66
3h5gB-4ki9A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 4 LEU H 369
GLN H 374
LEU H 372
GLU H 373
 None
 1.07A 3h5gA-4l0oH:
undetectable
3h5gB-4l0oH:
undetectable		 3h5gA-4l0oH:
5.41
3h5gB-4l0oH:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION

(Cryptosporidium
parvum) 		PF00856
(SET) 		4 LEU A 213
GLN A  21
LEU A  19
GLU A  18
 None
 1.14A 3h5gA-4ldgA:
undetectable
3h5gB-4ldgA:
undetectable		 3h5gA-4ldgA:
9.68
3h5gB-4ldgA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens) 		PF08242
(Methyltransf_12)
PF08659
(KR) 		4 LEU A2056
LYS A1116
GLN A2059
LEU A2106
 None
SO4  A2203 ( 4.8A)
None
None
 1.07A 3h5gA-4pivA:
undetectable
3h5gB-4pivA:
undetectable		 3h5gA-4pivA:
3.79
3h5gB-4pivA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 LEU A  72
GLN A  25
LEU A  27
GLU A  28
 None
 1.00A 3h5gA-4qgkA:
undetectable
3h5gB-4qgkA:
undetectable		 3h5gA-4qgkA:
5.56
3h5gB-4qgkA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4k UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		no annotation 4 LEU A 161
GLN A 168
LEU A 166
GLU A 165
 None
 0.95A 3h5gA-4r4kA:
undetectable
3h5gB-4r4kA:
undetectable		 3h5gA-4r4kA:
12.99
3h5gB-4r4kA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uym 14-ALPHA STEROL
DEMETHYLASE

(Aspergillus
fumigatus) 		PF00067
(p450) 		4 LEU A 358
GLN A 335
LEU A 333
GLU A 332
 None
 1.11A 3h5gA-4uymA:
undetectable
3h5gB-4uymA:
undetectable		 3h5gA-4uymA:
5.85
3h5gB-4uymA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 LEU A 315
GLN A 351
LEU A 353
GLU A 352
 None
 1.07A 3h5gA-4v2xA:
undetectable
3h5gB-4v2xA:
undetectable		 3h5gA-4v2xA:
4.28
3h5gB-4v2xA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wid RHUL123

(Macacine
betaherpesvirus
3) 		PF07340
(Herpes_IE1) 		4 LEU A  44
GLN A 139
LEU A 137
GLU A 138
 None
 1.10A 3h5gA-4widA:
undetectable
3h5gB-4widA:
undetectable		 3h5gA-4widA:
6.17
3h5gB-4widA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A 687
LYS A 859
LEU A 863
GLU A 864
 None
 1.12A 3h5gA-4xgtA:
undetectable
3h5gB-4xgtA:
undetectable		 3h5gA-4xgtA:
3.21
3h5gB-4xgtA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER

(Escherichia
coli) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 LEU A 133
LYS A 153
GLN A 155
LEU A 157
 None
 0.69A 3h5gA-4y13A:
undetectable
3h5gB-4y13A:
undetectable		 3h5gA-4y13A:
7.82
3h5gB-4y13A:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynq THREE-PRIME REPAIR
EXONUCLEASE 1

(Mus musculus) 		no annotation 4 LEU A 159
GLN A 164
LEU A 162
GLU A 163
 None
 1.10A 3h5gA-4ynqA:
undetectable
3h5gB-4ynqA:
undetectable		 3h5gA-4ynqA:
10.21
3h5gB-4ynqA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 LEU A 122
LYS A 101
LEU A 105
GLU A 106
 None
 1.10A 3h5gA-5ce6A:
undetectable
3h5gB-5ce6A:
undetectable		 3h5gA-5ce6A:
6.44
3h5gB-5ce6A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cy4 OLIGORIBONUCLEASE

(Acinetobacter
baumannii) 		PF00929
(RNase_T) 		4 LEU A  91
GLN A 126
LEU A 124
GLU A 123
 None
 0.88A 3h5gA-5cy4A:
undetectable
3h5gB-5cy4A:
undetectable		 3h5gA-5cy4A:
7.69
3h5gB-5cy4A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn7 PROTEIN FAM179B

(Mus musculus) 		no annotation 4 LEU A 354
GLN A 376
LEU A 374
GLU A 373
 None
 1.09A 3h5gA-5dn7A:
undetectable
3h5gB-5dn7A:
undetectable		 3h5gA-5dn7A:
8.57
3h5gB-5dn7A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fac ALANINE RACEMASE

(Streptomyces
coelicolor) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 178
GLN A 209
LEU A 212
GLU A 208
 None
 1.12A 3h5gA-5facA:
undetectable
3h5gB-5facA:
undetectable		 3h5gA-5facA:
6.00
3h5gB-5facA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyk MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Saccharomyces
cerevisiae) 		PF10296
(MMM1) 		4 LEU A 256
LYS A 249
LEU A 252
GLU A 255
 PEE  A 301 (-4.8A)
None
None
PEE  A 301 (-3.9A)
 1.10A 3h5gA-5gykA:
undetectable
3h5gB-5gykA:
undetectable		 3h5gA-5gykA:
10.00
3h5gB-5gykA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		4 LEU A  89
GLN A  80
LEU A  82
GLU A  83
 None
 1.08A 3h5gA-5hgcA:
undetectable
3h5gB-5hgcA:
undetectable		 3h5gA-5hgcA:
5.38
3h5gB-5hgcA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		4 LEU A 114
LYS A 444
GLN A 446
LEU A 477
 None
 1.09A 3h5gA-5hy5A:
undetectable
3h5gB-5hy5A:
undetectable		 3h5gA-5hy5A:
4.61
3h5gB-5hy5A:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7z MATERNAL PROTEIN
EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 LEU A 116
GLN A 121
LEU A 119
GLU A 120
 None
 1.15A 3h5gA-5l7zA:
undetectable
3h5gB-5l7zA:
undetectable		 3h5gA-5l7zA:
6.01
3h5gB-5l7zA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 307
GLN A 312
LEU A 310
GLU A 311
 None
 1.07A 3h5gA-5mfdA:
undetectable
3h5gB-5mfdA:
undetectable		 3h5gA-5mfdA:
6.44
3h5gB-5mfdA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 4 LEU A 314
LYS A 203
GLN A 205
LEU A 207
 None
None
EDO  A 605 (-2.9A)
None
 1.14A 3h5gA-5nzgA:
undetectable
3h5gB-5nzgA:
undetectable		 3h5gA-5nzgA:
undetectable
3h5gB-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojl IMINE REDUCTASE

(Aspergillus
terreus) 		no annotation 4 LEU A 107
GLN A  79
LEU A  81
GLU A  78
 None
TXP  A 302 (-3.9A)
None
None
 1.13A 3h5gA-5ojlA:
undetectable
3h5gB-5ojlA:
undetectable		 3h5gA-5ojlA:
undetectable
3h5gB-5ojlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 LEU A  80
GLN A  33
LEU A  35
GLU A  36
 None
 1.04A 3h5gA-5ucdA:
undetectable
3h5gB-5ucdA:
undetectable		 3h5gA-5ucdA:
5.22
3h5gB-5ucdA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3
PROTEIN SALVADOR
HOMOLOG 1

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 LEU A 466
GLN B 349
LEU B 347
GLU B 346
 None
 0.68A 3h5gA-6ao5A:
undetectable
3h5gB-6ao5A:
undetectable		 3h5gA-6ao5A:
6.35
3h5gB-6ao5A:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4j NUCLEOPORIN LIKE 2

(Homo sapiens) 		no annotation 4 LEU C 393
GLN C 400
LEU C 398
GLU C 397
 None
 1.15A 3h5gA-6b4jC:
undetectable
3h5gB-6b4jC:
undetectable		 3h5gA-6b4jC:
undetectable
3h5gB-6b4jC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5c 3-DEHYDROQUINATE
SYNTHASE

(Candida
albicans) 		no annotation 4 LEU A 386
LYS A 379
GLN A 380
LEU A 382
 None
 1.06A 3h5gA-6c5cA:
undetectable
3h5gB-6c5cA:
undetectable		 3h5gA-6c5cA:
undetectable
3h5gB-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 4 LEU A 708
GLN A 686
LEU A 690
GLU A 687
 None
 1.02A 3h5gA-6d6yA:
undetectable
3h5gB-6d6yA:
undetectable		 3h5gA-6d6yA:
undetectable
3h5gB-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 LEU A1038
GLN A1129
LEU A1127
GLU A1126
 None
 0.95A 3h5gA-6fikA:
undetectable
3h5gB-6fikA:
undetectable		 3h5gA-6fikA:
undetectable
3h5gB-6fikA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 4 LEU A 339
GLN A 374
LEU A 376
GLU A 373
 None
 1.12A 3h5gA-6gnfA:
undetectable
3h5gB-6gnfA:
undetectable		 3h5gA-6gnfA:
undetectable
3h5gB-6gnfA:
undetectable