SIMILAR PATTERNS OF AMINO ACIDS FOR 3H5G_A_LEIA16

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elk TARGET OF MYB1

(Homo sapiens) 		PF00790
(VHS) 		4 LEU A  74
GLU A  75
LYS A 116
LEU A 120
 None
 0.80A 3h5gA-1elkA:
undetectable
3h5gC-1elkA:
undetectable		 3h5gA-1elkA:
12.10
3h5gC-1elkA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6z BAG-FAMILY MOLECULAR
CHAPERONE
REGULATOR-1

(Mus musculus) 		PF02179
(BAG) 		5 LYS A 106
LEU A 110
GLU A 111
LYS A 181
LEU A 185
 None
 0.84A 3h5gA-1i6zA:
undetectable
3h5gC-1i6zA:
undetectable		 3h5gA-1i6zA:
13.33
3h5gC-1i6zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		4 GLN A 226
GLU A 229
LYS A 255
LEU A 257
 None
 0.83A 3h5gA-1k1dA:
undetectable
3h5gC-1k1dA:
undetectable		 3h5gA-1k1dA:
5.00
3h5gC-1k1dA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldd ANAPHASE PROMOTING
COMPLEX

(Saccharomyces
cerevisiae) 		PF08672
(ANAPC2) 		4 GLN A 820
LEU A 822
GLU A 823
LEU A 797
 None
 0.88A 3h5gA-1lddA:
undetectable
3h5gC-1lddA:
undetectable		 3h5gA-1lddA:
20.00
3h5gC-1lddA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Gallus gallus;
Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 GLN B 185
LEU B 187
GLU B 188
LEU C 124
 None
 0.90A 3h5gA-1m1jB:
undetectable
3h5gC-1m1jB:
undetectable		 3h5gA-1m1jB:
5.29
3h5gC-1m1jB:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7k SILENCER OF DEATH
DOMAINS

(Homo sapiens) 		PF02179
(BAG) 		4 GLN A 391
LEU A 393
GLU A 394
LYS A 444
 None
 0.87A 3h5gA-1m7kA:
undetectable
3h5gC-1m7kA:
undetectable		 3h5gA-1m7kA:
15.15
3h5gC-1m7kA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A

(Escherichia
coli) 		PF02861
(Clp_N) 		4 GLN A  56
LEU A  58
GLU A  59
LEU A  32
 None
 0.79A 3h5gA-1mbxA:
undetectable
3h5gC-1mbxA:
undetectable		 3h5gA-1mbxA:
11.89
3h5gC-1mbxA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4v PHOSPHORIBOSYLAMINOI
MIDAZOLE MUTASE PURE

(Thermotoga
maritima) 		PF00731
(AIRC) 		4 LYS A 154
GLN A 156
LEU A 158
GLU A 159
 None
 0.92A 3h5gA-1o4vA:
undetectable
3h5gC-1o4vA:
undetectable		 3h5gA-1o4vA:
9.29
3h5gC-1o4vA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4q SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00435
(Spectrin) 		4 LYS A1704
GLN A1706
LEU A1708
GLU A1709
 None
 0.89A 3h5gA-1u4qA:
undetectable
3h5gC-1u4qA:
undetectable		 3h5gA-1u4qA:
8.60
3h5gC-1u4qA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujj ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF00790
(VHS) 		4 LEU A  70
GLU A  71
LYS A 114
LEU A 118
 None
 0.86A 3h5gA-1ujjA:
undetectable
3h5gC-1ujjA:
undetectable		 3h5gA-1ujjA:
14.58
3h5gC-1ujjA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLN A 235
GLU A 238
LYS A  24
LEU A  26
 None
 0.48A 3h5gA-1uxiA:
undetectable
3h5gC-1uxiA:
undetectable		 3h5gA-1uxiA:
6.47
3h5gC-1uxiA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE

(Cavia porcellus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 GLN A 229
LEU A 227
LYS A 263
LEU A 265
 None
 0.83A 3h5gA-1v3tA:
undetectable
3h5gC-1v3tA:
undetectable		 3h5gA-1v3tA:
6.79
3h5gC-1v3tA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 GLN B  91
LEU B  89
GLU B  88
LYS B 110
 None
 0.92A 3h5gA-1wa5B:
undetectable
3h5gC-1wa5B:
undetectable		 3h5gA-1wa5B:
5.43
3h5gC-1wa5B:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 GLN A 390
LEU A 392
GLU A 393
LEU A 199
 None
 0.92A 3h5gA-1xzqA:
undetectable
3h5gC-1xzqA:
undetectable		 3h5gA-1xzqA:
4.56
3h5gC-1xzqA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 GLN A 358
LEU A 360
GLU A 361
LEU A 399
 None
 0.78A 3h5gA-1y4uA:
undetectable
3h5gC-1y4uA:
undetectable		 3h5gA-1y4uA:
4.47
3h5gC-1y4uA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2

(Homo sapiens) 		PF00632
(HECT) 		4 GLN A 385
LEU A 383
GLU A 382
LEU A 613
 None
 0.69A 3h5gA-1zvdA:
undetectable
3h5gC-1zvdA:
undetectable		 3h5gA-1zvdA:
6.10
3h5gC-1zvdA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 GLN A 818
LEU A 820
GLU A 821
LEU A 976
 None
 0.92A 3h5gA-1zy4A:
undetectable
3h5gC-1zy4A:
undetectable		 3h5gA-1zy4A:
7.26
3h5gC-1zy4A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 GLN A 118
LEU A 120
GLU A 121
LEU A 266
 None
 0.72A 3h5gA-2bdwA:
undetectable
3h5gC-2bdwA:
undetectable		 3h5gA-2bdwA:
6.96
3h5gC-2bdwA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		4 GLN A 288
LEU A 286
GLU A 287
LEU A 271
 None
 0.87A 3h5gA-2d7dA:
undetectable
3h5gC-2d7dA:
undetectable		 3h5gA-2d7dA:
4.29
3h5gC-2d7dA:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcw ALPHA-2-MACROGLOBULI
N
RECEPTOR-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF06401
(Alpha-2-MRAP_C) 		4 LYS A 289
LEU A 293
GLU A 294
LEU A 264
 None
 0.94A 3h5gA-2fcwA:
undetectable
3h5gC-2fcwA:
undetectable		 3h5gA-2fcwA:
16.67
3h5gC-2fcwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		4 GLN A 168
LEU A 166
GLU A 165
LEU A 121
 None
 0.90A 3h5gA-2ftpA:
undetectable
3h5gC-2ftpA:
undetectable		 3h5gA-2ftpA:
6.95
3h5gC-2ftpA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		4 GLN A 358
LEU A 360
GLU A 361
LEU A 399
 None
 0.82A 3h5gA-2gq0A:
undetectable
3h5gC-2gq0A:
undetectable		 3h5gA-2gq0A:
8.33
3h5gC-2gq0A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 GLN A 358
LEU A 360
GLU A 361
LEU A 399
 None
 0.90A 3h5gA-2iopA:
undetectable
3h5gC-2iopA:
undetectable		 3h5gA-2iopA:
4.28
3h5gC-2iopA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 GLN A  81
LEU A  79
GLU A  82
LEU A 194
 None
 0.93A 3h5gA-2q8hA:
undetectable
3h5gC-2q8hA:
undetectable		 3h5gA-2q8hA:
7.46
3h5gC-2q8hA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 147
LEU A 149
GLU A 150
LEU A 295
 None
 0.93A 3h5gA-2w4oA:
undetectable
3h5gC-2w4oA:
undetectable		 3h5gA-2w4oA:
7.37
3h5gC-2w4oA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmy PUTATIVE ACID
PHOSPHATASE WZB

(Escherichia
coli) 		PF01451
(LMWPc) 		4 GLN A 133
LEU A 135
GLU A 136
LEU A  26
 None
 0.88A 3h5gA-2wmyA:
undetectable
3h5gC-2wmyA:
undetectable		 3h5gA-2wmyA:
12.67
3h5gC-2wmyA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpw ORF14

(Streptomyces
clavuligerus) 		PF00583
(Acetyltransf_1) 		4 LYS A 285
LEU A 289
GLU A 290
LEU A 169
 None
 0.88A 3h5gA-2wpwA:
undetectable
3h5gC-2wpwA:
undetectable		 3h5gA-2wpwA:
6.82
3h5gC-2wpwA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		4 GLN A 708
LEU A 710
GLU A 711
LEU A 660
 None
 0.91A 3h5gA-2x24A:
undetectable
3h5gC-2x24A:
undetectable		 3h5gA-2x24A:
3.59
3h5gC-2x24A:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		4 GLN A 490
LEU A 492
GLU A 489
LEU A 452
 None
 0.75A 3h5gA-2xssA:
undetectable
3h5gC-2xssA:
undetectable		 3h5gA-2xssA:
11.05
3h5gC-2xssA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 119
LEU A 121
GLU A 122
LEU A 267
 None
 0.78A 3h5gA-3bhhA:
undetectable
3h5gC-3bhhA:
undetectable		 3h5gA-3bhhA:
7.46
3h5gC-3bhhA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 124
LEU A 126
GLU A 127
LEU A 271
 None
 0.87A 3h5gA-3c0iA:
undetectable
3h5gC-3c0iA:
undetectable		 3h5gA-3c0iA:
7.17
3h5gC-3c0iA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daw TWINFILIN-1

(Mus musculus) 		PF00241
(Cofilin_ADF) 		4 GLN B 188
LEU B 190
GLU B 191
LEU B 287
 None
 0.87A 3h5gA-3dawB:
undetectable
3h5gC-3dawB:
undetectable		 3h5gA-3dawB:
12.74
3h5gC-3dawB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2

(Homo sapiens) 		PF04042
(DNA_pol_E_B) 		4 LEU A 365
GLU A 366
LYS A 413
LEU A 425
 None
 0.71A 3h5gA-3e0jA:
undetectable
3h5gC-3e0jA:
undetectable		 3h5gA-3e0jA:
4.83
3h5gC-3e0jA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		4 LEU A 133
GLU A 132
LYS A 268
LEU A 272
 None
 0.92A 3h5gA-3fqdA:
undetectable
3h5gC-3fqdA:
undetectable		 3h5gA-3fqdA:
2.90
3h5gC-3fqdA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 284
GLU A 285
LYS A 313
LEU A 317
 None
 0.78A 3h5gA-3g7sA:
undetectable
3h5gC-3g7sA:
undetectable		 3h5gA-3g7sA:
4.92
3h5gC-3g7sA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLN A 241
GLU A 244
LYS A  25
LEU A  27
 None
 0.86A 3h5gA-3gvhA:
undetectable
3h5gC-3gvhA:
undetectable		 3h5gA-3gvhA:
11.54
3h5gC-3gvhA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2d E3 SUMO-PROTEIN
LIGASE SIZ1

(Saccharomyces
cerevisiae) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		4 GLN A 318
LEU A 320
GLU A 317
LEU A 386
 None
 0.79A 3h5gA-3i2dA:
undetectable
3h5gC-3i2dA:
undetectable		 3h5gA-3i2dA:
6.79
3h5gC-3i2dA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9y SENSOR PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 4 GLN A 159
LEU A 157
GLU A 156
LEU A 268
 None
 0.90A 3h5gA-3i9yA:
undetectable
3h5gC-3i9yA:
undetectable		 3h5gA-3i9yA:
10.09
3h5gC-3i9yA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ism CG4930

(Drosophila
melanogaster) 		PF08785
(Ku_PK_bind) 		5 GLN C  90
LEU C  92
GLU C  93
LYS C 134
LEU C 136
 None
 0.70A 3h5gA-3ismC:
undetectable
3h5gC-3ismC:
undetectable		 3h5gA-3ismC:
6.19
3h5gC-3ismC:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		4 GLN A  69
LEU A  67
GLU A  66
LEU A  54
 None
 0.84A 3h5gA-3k2gA:
undetectable
3h5gC-3k2gA:
undetectable		 3h5gA-3k2gA:
5.77
3h5gC-3k2gA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 GLN A 118
LEU A 120
GLU A 121
LEU A 265
 None
 0.74A 3h5gA-3kl8A:
undetectable
3h5gC-3kl8A:
undetectable		 3h5gA-3kl8A:
11.98
3h5gC-3kl8A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		4 GLN A 490
LEU A 492
GLU A 489
LEU A 452
 None
 0.77A 3h5gA-3lfvA:
undetectable
3h5gC-3lfvA:
undetectable		 3h5gA-3lfvA:
6.52
3h5gC-3lfvA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 141
LEU A 143
GLU A 144
LEU A 288
 None
 0.85A 3h5gA-3lm5A:
undetectable
3h5gC-3lm5A:
undetectable		 3h5gA-3lm5A:
6.12
3h5gC-3lm5A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		4 LEU A 648
GLU A 649
LYS A 743
LEU A 747
 None
 0.93A 3h5gA-3m62A:
undetectable
3h5gC-3m62A:
undetectable		 3h5gA-3m62A:
2.82
3h5gC-3m62A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n29 CARBOXYNORSPERMIDINE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00278
(Orn_DAP_Arg_deC) 		4 LEU A 176
GLU A 177
LYS A 214
LEU A 218
 None
 0.94A 3h5gA-3n29A:
undetectable
3h5gC-3n29A:
undetectable		 3h5gA-3n29A:
8.46
3h5gC-3n29A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7m MALATE DEHYDROGENASE

(Francisella
tularensis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLN A 241
GLU A 244
LYS A  25
LEU A  27
 None
 0.68A 3h5gA-3p7mA:
undetectable
3h5gC-3p7mA:
undetectable		 3h5gA-3p7mA:
7.58
3h5gC-3p7mA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgv HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Klebsiella
pneumoniae) 		PF08282
(Hydrolase_3) 		4 GLN A 162
LEU A 160
GLU A 161
LEU A 182
 None
 0.85A 3h5gA-3pgvA:
undetectable
3h5gC-3pgvA:
undetectable		 3h5gA-3pgvA:
7.81
3h5gC-3pgvA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgv HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Klebsiella
pneumoniae) 		PF08282
(Hydrolase_3) 		4 LYS A 191
LEU A 195
GLU A 196
LEU A 206
 EPE  A 268 (-3.1A)
None
None
None
 0.86A 3h5gA-3pgvA:
undetectable
3h5gC-3pgvA:
undetectable		 3h5gA-3pgvA:
7.81
3h5gC-3pgvA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj4 RENALASE

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 GLN A 183
LEU A 185
GLU A 186
LEU A 167
 None
 0.84A 3h5gA-3qj4A:
undetectable
3h5gC-3qj4A:
undetectable		 3h5gA-3qj4A:
6.14
3h5gC-3qj4A:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcm TATD FAMILY
HYDROLASE

(Pseudomonas
putida) 		PF01026
(TatD_DNase) 		4 GLN A  46
LEU A  48
GLU A  45
LEU A  86
 None
 0.85A 3h5gA-3rcmA:
undetectable
3h5gC-3rcmA:
undetectable		 3h5gA-3rcmA:
7.97
3h5gC-3rcmA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwr DNA REPAIR PROTEIN
XRCC4

(Homo sapiens) 		PF06632
(XRCC4) 		4 LEU A  70
GLU A  69
LYS A  99
LEU A 108
 None
 0.91A 3h5gA-3rwrA:
undetectable
3h5gC-3rwrA:
undetectable		 3h5gA-3rwrA:
12.88
3h5gC-3rwrA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umc HALOACID
DEHALOGENASE

(Pseudomonas
aeruginosa) 		PF13419
(HAD_2) 		4 GLN A  70
LEU A  72
GLU A  73
LEU A  88
 None
 0.81A 3h5gA-3umcA:
undetectable
3h5gC-3umcA:
undetectable		 3h5gA-3umcA:
8.93
3h5gC-3umcA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtf UDP-GLUCOSE
6-DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLN A 302
LEU A 304
GLU A 305
LEU A 311
 None
 0.85A 3h5gA-3vtfA:
undetectable
3h5gC-3vtfA:
undetectable		 3h5gA-3vtfA:
6.27
3h5gC-3vtfA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpj TON_1535

(Thermococcus
onnurineus) 		no annotation 4 LYS A 327
LEU A 323
GLU A 322
LEU A 296
 None
 0.77A 3h5gA-3zpjA:
undetectable
3h5gC-3zpjA:
undetectable		 3h5gA-3zpjA:
7.34
3h5gC-3zpjA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 140
LEU A 142
GLU A 143
LEU A 289
 None
 0.84A 3h5gA-4bc6A:
undetectable
3h5gC-4bc6A:
undetectable		 3h5gA-4bc6A:
8.19
3h5gC-4bc6A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfc 3-DEOXY-D-MANNO-OCTU
LOSONIC-ACID
TRANSFERASE

(Acinetobacter
baumannii) 		no annotation 4 GLN A 252
LEU A 254
GLU A 255
LEU A 289
 None
 0.75A 3h5gA-4bfcA:
undetectable
3h5gC-4bfcA:
undetectable		 3h5gA-4bfcA:
7.96
3h5gC-4bfcA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 GLN A 480
LEU A 482
GLU A 479
LEU A 555
 None
 0.80A 3h5gA-4c1oA:
undetectable
3h5gC-4c1oA:
undetectable		 3h5gA-4c1oA:
3.30
3h5gC-4c1oA:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10

(Homo sapiens;
synthetic
construct) 		no annotation
no annotation 		4 GLN A  39
LEU A  41
GLU A  42
LEU B  42
 None
 0.80A 3h5gA-4c7nA:
undetectable
3h5gC-4c7nA:
undetectable		 3h5gA-4c7nA:
26.00
3h5gC-4c7nA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10

(Homo sapiens;
synthetic
construct) 		no annotation
no annotation 		4 GLN B  40
LEU B  42
GLU B  43
LEU A  41
 None
 0.69A 3h5gA-4c7nB:
undetectable
3h5gC-4c7nB:
undetectable		 3h5gA-4c7nB:
22.64
3h5gC-4c7nB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG

(Homo sapiens) 		PF02854
(MIF4G) 		4 GLN B 187
LEU B 185
GLU B 184
LEU B 169
 None
 0.85A 3h5gA-4c9bB:
undetectable
3h5gC-4c9bB:
undetectable		 3h5gA-4c9bB:
9.63
3h5gC-4c9bB:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4r PHOSPHATE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF01515
(PTA_PTB) 		4 LYS A  52
GLN A  54
LEU A  56
LEU A  30
 None
 0.56A 3h5gA-4e4rA:
undetectable
3h5gC-4e4rA:
undetectable		 3h5gA-4e4rA:
8.57
3h5gC-4e4rA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLN A 916
LEU A 918
GLU A 919
LEU A 941
 None
 0.90A 3h5gA-4fysA:
undetectable
3h5gC-4fysA:
undetectable		 3h5gA-4fysA:
2.77
3h5gC-4fysA:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g54 GENERAL SECRETION
PATHWAY PROTEIN

(Vibrio
vulnificus) 		PF01471
(PG_binding_1) 		4 GLN A 499
LEU A 497
GLU A 496
LEU A 488
 None
 0.86A 3h5gA-4g54A:
undetectable
3h5gC-4g54A:
undetectable		 3h5gA-4g54A:
8.13
3h5gC-4g54A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 GLN C 199
LEU C 201
GLU C 202
LEU C 237
 None
 0.84A 3h5gA-4hb4C:
undetectable
3h5gC-4hb4C:
undetectable		 3h5gA-4hb4C:
2.58
3h5gC-4hb4C:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 GLN A  36
LEU A  38
GLU A  37
LEU A   4
 None
 0.93A 3h5gA-4jgiA:
undetectable
3h5gC-4jgiA:
undetectable		 3h5gA-4jgiA:
9.76
3h5gC-4jgiA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxc FEFE-HYDROGENASE
MATURASE

(Thermotoga
maritima) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 LYS A  21
LEU A  20
LYS A 251
LEU A 255
 None
 0.91A 3h5gA-4jxcA:
undetectable
3h5gC-4jxcA:
undetectable		 3h5gA-4jxcA:
6.47
3h5gC-4jxcA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 GLN A 524
LEU A 526
GLU A 523
LEU A 201
 None
 0.91A 3h5gA-4nbqA:
undetectable
3h5gC-4nbqA:
undetectable		 3h5gA-4nbqA:
3.90
3h5gC-4nbqA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkb PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE ZYG-1

(Caenorhabditis
elegans) 		no annotation 4 GLN A 540
LEU A 535
GLU A 539
LEU A 482
 None
 0.89A 3h5gA-4nkbA:
undetectable
3h5gC-4nkbA:
undetectable		 3h5gA-4nkbA:
7.11
3h5gC-4nkbA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 GLN A 592
LEU A 594
GLU A 595
LEU A 537
 None
 0.90A 3h5gA-4nmeA:
undetectable
3h5gC-4nmeA:
undetectable		 3h5gA-4nmeA:
2.76
3h5gC-4nmeA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 LYS A 364
GLN A 366
LEU A 368
LEU A 351
 None
 0.91A 3h5gA-4nrhA:
undetectable
3h5gC-4nrhA:
undetectable		 3h5gA-4nrhA:
13.25
3h5gC-4nrhA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		4 GLN A 201
LEU A 203
GLU A 200
LEU A 224
 None
 0.92A 3h5gA-4q0cA:
undetectable
3h5gC-4q0cA:
undetectable		 3h5gA-4q0cA:
4.30
3h5gC-4q0cA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 GLN A 458
LEU A 460
GLU A 457
LEU A 533
 None
 0.84A 3h5gA-4rhhA:
undetectable
3h5gC-4rhhA:
undetectable		 3h5gA-4rhhA:
3.69
3h5gC-4rhhA:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uht TRANSCRIPTIONAL
REGULATORY PROTEIN
CPXR

(Escherichia
coli) 		PF00486
(Trans_reg_C) 		4 GLN A 183
LEU A 181
GLU A 184
LEU A 167
 None
 0.85A 3h5gA-4uhtA:
undetectable
3h5gC-4uhtA:
undetectable		 3h5gA-4uhtA:
13.83
3h5gC-4uhtA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		4 GLN A 761
LEU A 759
GLU A 758
LEU A 781
 None
 0.80A 3h5gA-4xjxA:
undetectable
3h5gC-4xjxA:
undetectable		 3h5gA-4xjxA:
2.61
3h5gC-4xjxA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0c CLP PROTEASE-RELATED
PROTEIN AT4G12060,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 LYS B 225
LEU B 229
GLU B 230
LEU B 202
 None
 0.77A 3h5gA-4y0cB:
undetectable
3h5gC-4y0cB:
undetectable		 3h5gA-4y0cB:
13.87
3h5gC-4y0cB:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		4 GLN A 194
LEU A 196
GLU A 193
LEU A 225
 None
 0.82A 3h5gA-4yr1A:
undetectable
3h5gC-4yr1A:
undetectable		 3h5gA-4yr1A:
5.91
3h5gC-4yr1A:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		4 GLN A 255
LEU A 257
GLU A 258
LEU A 370
 None
 0.92A 3h5gA-4zk3A:
undetectable
3h5gC-4zk3A:
undetectable		 3h5gA-4zk3A:
6.16
3h5gC-4zk3A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zry KERATIN, TYPE I
CYTOSKELETAL 10
KERATIN, TYPE II
CYTOSKELETAL 1

(Homo sapiens;
Homo sapiens) 		PF00038
(Filament)
PF00038
(Filament)
PF11839
(Alanine_zipper) 		4 GLN A 387
LEU A 389
GLU A 390
LEU B 422
 None
 0.86A 3h5gA-4zryA:
undetectable
3h5gC-4zryA:
undetectable		 3h5gA-4zryA:
16.13
3h5gC-4zryA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		4 GLN A 437
LEU A 435
GLU A 436
LEU A 471
 None
 0.85A 3h5gA-5a2aA:
undetectable
3h5gC-5a2aA:
undetectable		 3h5gA-5a2aA:
5.73
3h5gC-5a2aA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ako TSI2

(Pseudomonas
aeruginosa) 		no annotation 4 GLN A  39
LEU A  37
GLU A  38
LEU A  26
 None
 0.85A 3h5gA-5akoA:
undetectable
3h5gC-5akoA:
undetectable		 3h5gA-5akoA:
18.18
3h5gC-5akoA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 GLN A 408
LEU A 410
GLU A 411
LEU A 435
 None
 0.60A 3h5gA-5ddsA:
undetectable
3h5gC-5ddsA:
undetectable		 3h5gA-5ddsA:
5.02
3h5gC-5ddsA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h69 CHROMOSOME PARTITION
PROTEIN SMC

(Geobacillus
stearothermophilus) 		PF06470
(SMC_hinge) 		4 GLN A 491
LEU A 493
GLU A 494
LEU A 679
 None
 0.75A 3h5gA-5h69A:
undetectable
3h5gC-5h69A:
undetectable		 3h5gA-5h69A:
7.28
3h5gC-5h69A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLN A 262
LEU A 260
GLU A 263
LEU A 121
 None
None
EDO  A 504 (-3.9A)
EDO  A 504 (-4.8A)
 0.94A 3h5gA-5h80A:
undetectable
3h5gC-5h80A:
undetectable		 3h5gA-5h80A:
4.93
3h5gC-5h80A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 GLN A 119
LEU A 121
GLU A 122
LEU A 267
 None
 0.81A 3h5gA-5hu3A:
undetectable
3h5gC-5hu3A:
undetectable		 3h5gA-5hu3A:
8.07
3h5gC-5hu3A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4o SPECTRIN ALPHA
CHAIN, ERYTHROCYTIC
1

(Homo sapiens) 		PF00435
(Spectrin) 		4 LYS A  50
GLN A  52
LEU A  54
GLU A  55
 None
 0.88A 3h5gA-5j4oA:
undetectable
3h5gC-5j4oA:
undetectable		 3h5gA-5j4oA:
9.96
3h5gC-5j4oA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Trichormus
variabilis) 		PF00701
(DHDPS) 		4 GLN A 282
LEU A 284
GLU A 285
LEU A 261
 None
 0.89A 3h5gA-5ktlA:
undetectable
3h5gC-5ktlA:
undetectable		 3h5gA-5ktlA:
5.79
3h5gC-5ktlA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLN A 968
LEU A 966
GLU A 967
LEU A1162
 None
 0.85A 3h5gA-5n0cA:
undetectable
3h5gC-5n0cA:
undetectable		 3h5gA-5n0cA:
2.19
3h5gC-5n0cA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LYS A3225
GLN A3227
LEU A3229
GLU A3230
 None
 0.87A 3h5gA-5nugA:
undetectable
3h5gC-5nugA:
undetectable		 3h5gA-5nugA:
0.60
3h5gC-5nugA:
0.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdy FLAGELLAR M-RING
PROTEIN
FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima;
Thermotoga
maritima) 		no annotation
PF14842
(FliG_N) 		4 GLN B  56
LEU B  58
GLU B  59
LEU A  12
 None
 0.77A 3h5gA-5tdyB:
undetectable
3h5gC-5tdyB:
undetectable		 3h5gA-5tdyB:
19.35
3h5gC-5tdyB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 4 GLN B 236
LEU B 234
GLU B 235
LEU B 270
 None
 0.86A 3h5gA-5txrB:
undetectable
3h5gC-5txrB:
undetectable		 3h5gA-5txrB:
undetectable
3h5gC-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		4 LYS A 406
GLN A 408
LEU A 410
LEU A  12
 None
 0.88A 3h5gA-5u4hA:
undetectable
3h5gC-5u4hA:
undetectable		 3h5gA-5u4hA:
6.05
3h5gC-5u4hA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8w INTEGRATOR COMPLEX
SUBUNIT 9
INTEGRATOR COMPLEX
SUBUNIT 11

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 GLN B 497
LEU B 499
GLU B 496
LEU A 584
 None
 0.82A 3h5gA-5v8wB:
undetectable
3h5gC-5v8wB:
undetectable		 3h5gA-5v8wB:
17.43
3h5gC-5v8wB:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 4 GLN A 786
LEU A 788
GLU A 789
LEU A 933
 None
 0.76A 3h5gA-5vilA:
undetectable
3h5gC-5vilA:
undetectable		 3h5gA-5vilA:
undetectable
3h5gC-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct) 		no annotation 4 GLN A  97
LEU A  95
GLU A  94
LEU A 106
 None
HEM  A 203 ( 4.5A)
None
None
 0.91A 3h5gA-5vjtA:
undetectable
3h5gC-5vjtA:
undetectable		 3h5gA-5vjtA:
undetectable
3h5gC-5vjtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whr INDOLEAMINE
2,3-DIOXYGENASE 1

(Homo sapiens) 		no annotation 4 LYS A  74
GLN A  76
LEU A  78
LEU A  32
 None
 0.64A 3h5gA-5whrA:
undetectable
3h5gC-5whrA:
undetectable		 3h5gA-5whrA:
undetectable
3h5gC-5whrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*

(unidentified) 		no annotation 4 GLN A  84
LEU A  82
LYS A 192
LEU A 190
 None
 0.94A 3h5gA-5wl7A:
undetectable
3h5gC-5wl7A:
undetectable		 3h5gA-5wl7A:
undetectable
3h5gC-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 4 GLN A 304
LEU A 306
GLU A 303
LEU A 341
 None
 0.47A 3h5gA-5xxgA:
undetectable
3h5gC-5xxgA:
undetectable		 3h5gA-5xxgA:
undetectable
3h5gC-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yma PUTATIVE RRNA
PROCESSING PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 GLN A 121
LEU A 123
GLU A 124
LEU A 143
 None
 0.89A 3h5gA-5ymaA:
undetectable
3h5gC-5ymaA:
undetectable		 3h5gA-5ymaA:
undetectable
3h5gC-5ymaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 4 GLN A 268
LEU A 270
GLU A 266
LEU A 248
 None
 0.91A 3h5gA-5yu1A:
undetectable
3h5gC-5yu1A:
undetectable		 3h5gA-5yu1A:
undetectable
3h5gC-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 4 LYS A 408
GLN A 410
LEU A 412
LEU A  12
 None
 0.89A 3h5gA-6cn1A:
undetectable
3h5gC-6cn1A:
undetectable		 3h5gA-6cn1A:
undetectable
3h5gC-6cn1A:
undetectable