SIMILAR PATTERNS OF AMINO ACIDS FOR 3GY3_A_PNTA246_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
None
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.61A 3gy3A-1a0jA:
40.0		 3gy3A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		9 HIS A  57
LEU A  99
GLN A 175
ASP A 189
SER A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
None
None
BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.45A 3gy3A-1a0jA:
40.0		 3gy3A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		7 HIS A  57
ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 0GJ  A 245 (-2.7A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-3.5A)
0GJ  A 245 (-1.4A)
None
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
 0.57A 3gy3A-1a5iA:
11.4		 3gy3A-1a5iA:
37.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1afq BOVINE
GAMMA-CHYMOTRYPSIN

(Bos taurus) 		PF00089
(Trypsin) 		5 SER C 190
SER C 195
TRP C 215
GLY C 216
GLY C 226
 None
0FG  C 301 ( 3.0A)
None
0FG  C 301 (-3.4A)
0FG  C 301 ( 4.4A)
 0.58A 3gy3A-1afqC:
11.2		 3gy3A-1afqC:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ao5 GLANDULAR
KALLIKREIN-13

(Mus musculus) 		PF00089
(Trypsin) 		5 HIS A  57
GLN A 174
ASP A 189
SER A 195
GLY A 216
 None
 0.81A 3gy3A-1ao5A:
13.4		 3gy3A-1ao5A:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 0GJ  A   1 ( 2.7A)
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
 0.48A 3gy3A-1bqyA:
34.1		 3gy3A-1bqyA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bru ELASTASE

(Sus scrofa) 		PF00089
(Trypsin) 		5 HIS P  57
LEU P  99
SER P 190
SER P 195
GLY P 216
 1NB  P   1 (-3.9A)
None
1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
1NB  P   1 ( 4.4A)
 0.74A 3gy3A-1bruP:
16.8		 3gy3A-1bruP:
40.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 GLN A 456
SER A 214
TRP A 119
GLY A 207
GLY A 211
 None
 1.15A 3gy3A-1cleA:
undetectable		 3gy3A-1cleA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLN A 456
SER A 214
TRP A 119
GLY A 207
GLY A 211
 None
 1.11A 3gy3A-1crlA:
undetectable		 3gy3A-1crlA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		6 HIS B  57
SER B 190
SER B 195
TRP B 215
GLY B 216
GLY B 226
 None
 0.67A 3gy3A-1dlkB:
35.8		 3gy3A-1dlkB:
43.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 LEU A 104
GLN A  86
GLY A 102
CYH A   1
GLY A 406
 None
ONL  A 505 (-4.2A)
ONL  A 505 (-3.7A)
ONL  A 505 ( 1.8A)
ONL  A 505 ( 4.2A)
 1.12A 3gy3A-1ecgA:
undetectable		 3gy3A-1ecgA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 LEU A 104
SER A 126
GLY A 102
CYH A   1
GLY A 406
 None
ONL  A 505 (-2.7A)
ONL  A 505 (-3.7A)
ONL  A 505 ( 1.8A)
ONL  A 505 ( 4.2A)
 1.15A 3gy3A-1ecgA:
undetectable		 3gy3A-1ecgA:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		7 HIS B  57
ASP B 189
SER B 190
GLN B 192
SER B 195
GLY B 216
GLY B 226
 None
 0.42A 3gy3A-1ekbB:
36.7		 3gy3A-1ekbB:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		7 HIS A 460
ASP A 611
SER A 612
SER A 617
TRP A 640
GLY A 641
GLY A 648
 SO4  A2001 ( 3.9A)
None
None
SO4  A2001 ( 2.7A)
None
None
None
 0.38A 3gy3A-1elvA:
11.1		 3gy3A-1elvA:
30.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ept PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
PORCINE E-TRYPSIN

(Sus scrofa;
Sus scrofa;
Sus scrofa) 		PF00089
(Trypsin)
PF00089
(Trypsin)
PF00089
(Trypsin) 		9 HIS A  57
LEU B  99
ASP C 189
SER C 190
GLN C 192
SER C 195
TRP C 215
GLY C 216
GLY C 226
 None
 0.41A 3gy3A-1eptA:
4.4		 3gy3A-1eptA:
90.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ept PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
PORCINE E-TRYPSIN

(Sus scrofa;
Sus scrofa;
Sus scrofa) 		PF00089
(Trypsin)
PF00089
(Trypsin)
PF00089
(Trypsin) 		9 HIS A  57
LEU B  99
GLN C 175
ASP C 189
SER C 190
SER C 195
TRP C 215
GLY C 216
GLY C 226
 None
 0.55A 3gy3A-1eptA:
4.4		 3gy3A-1eptA:
90.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1euf DUODENASE

(Bos taurus) 		PF00089
(Trypsin) 		5 HIS A  57
LEU A  99
SER A 190
SER A 195
GLY A 216
 None
 0.54A 3gy3A-1eufA:
16.7		 3gy3A-1eufA:
38.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		6 ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-3.2A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.81A 3gy3A-1fiwA:
16.4		 3gy3A-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.37A 3gy3A-1fiwA:
16.4		 3gy3A-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		7 HIS A  57
ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.6A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
 0.56A 3gy3A-1fizA:
16.9		 3gy3A-1fizA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA

(Homo sapiens) 		PF00089
(Trypsin) 		8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-3.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.48A 3gy3A-1fxyA:
37.0		 3gy3A-1fxyA:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gvl KALLIKREIN 6

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.57A 3gy3A-1gvlA:
27.6		 3gy3A-1gvlA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLN A 456
SER A 214
TRP A 119
GLY A 207
GLY A 211
 None
 1.17A 3gy3A-1gz7A:
undetectable		 3gy3A-1gz7A:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		9 HIS A  57
LEU A  99
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
None
BEN  A 250 (-2.9A)
BEN  A 250 (-2.9A)
BEN  A 250 (-3.8A)
BEN  A 250 (-3.6A)
None
BEN  A 250 (-3.9A)
BEN  A 250 (-3.3A)
 0.69A 3gy3A-1h4wA:
41.4		 3gy3A-1h4wA:
72.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		10 HIS E  57
LEU E  99
GLN E 175
ASP E 189
SER E 190
GLN E 192
SER E 195
TRP E 215
GLY E 216
GLY E 226
 None
 0.47A 3gy3A-1h9hE:
43.3		 3gy3A-1h9hE:
82.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		6 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 216
GLY H 226
 None
 0.53A 3gy3A-1id5H:
32.7		 3gy3A-1id5H:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		6 LEU H  99
ASP H 189
SER H 195
TRP H 215
GLY H 216
GLY H 226
 None
 0.94A 3gy3A-1id5H:
32.7		 3gy3A-1id5H:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		6 HIS T  57
ASP T 189
SER T 195
TRP T 215
GLY T 216
GLY T 226
 SO4  T 600 (-3.8A)
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
 0.29A 3gy3A-1j17T:
41.7		 3gy3A-1j17T:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		6 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 216
GLY H 226
 None
 0.49A 3gy3A-1kigH:
12.3		 3gy3A-1kigH:
40.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 HIS H  57
GLN H 192
SER H 195
TRP H 215
GLY H 216
 None
 0.90A 3gy3A-1kigH:
12.3		 3gy3A-1kigH:
40.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mbq TRYPSIN

(Oncorhynchus
keta) 		PF00089
(Trypsin) 		7 HIS A  57
ASP A 189
SER A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.34A 3gy3A-1mbqA:
39.9		 3gy3A-1mbqA:
65.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		6 HIS K  57
LEU K  99
SER K 195
TRP K 215
GLY K 216
GLY K 226
 None
 1.03A 3gy3A-1mkxK:
8.3		 3gy3A-1mkxK:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.50A 3gy3A-1npmA:
36.8		 3gy3A-1npmA:
45.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS H  57
GLN H 175
ASP H 189
SER H 195
TRP H 215
GLY H 216
GLY H 226
 CR9  H 256 (-3.9A)
None
CR9  H 256 (-2.4A)
CR9  H 256 (-1.5A)
None
CR9  H 256 ( 3.8A)
CR9  H 256 (-3.0A)
 0.63A 3gy3A-1o5fH:
18.6		 3gy3A-1o5fH:
41.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.53A 3gy3A-1op2A:
33.2		 3gy3A-1op2A:
41.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.39A 3gy3A-1orfA:
12.6		 3gy3A-1orfA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		7 HIS C  57
ASP C 189
SER C 190
SER C 195
TRP C 215
GLY C 216
GLY C 226
 0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.51A 3gy3A-1pfxC:
9.9		 3gy3A-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		8 HIS A  56
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 212
GLY A 213
GLY A 223
 ARG  A 703 (-4.3A)
ARG  A 703 (-2.0A)
ARG  A 703 (-2.5A)
ARG  A 703 (-3.1A)
ARG  A 703 (-2.3A)
None
ARG  A 703 ( 3.7A)
ARG  A 703 (-2.6A)
 0.36A 3gy3A-1pq5A:
34.3		 3gy3A-1pq5A:
44.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		7 HIS A 483
ASP A 627
SER A 628
SER A 633
TRP A 655
GLY A 656
GLY A 667
 None
NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.30A 3gy3A-1q3xA:
33.6		 3gy3A-1q3xA:
29.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		6 HIS G  57
ASP G 189
SER G 195
TRP G 215
GLY G 216
GLY G 226
 None
 0.56A 3gy3A-1sgfG:
35.5		 3gy3A-1sgfG:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
 None
 0.60A 3gy3A-1spjA:
37.4		 3gy3A-1spjA:
42.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
GLN A 174
ASP A 189
TRP A 215
GLY A 216
 None
 0.93A 3gy3A-1spjA:
37.4		 3gy3A-1spjA:
42.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		5 GLN A 470
SER A 222
TRP A 127
GLY A 215
GLY A 219
 None
 1.15A 3gy3A-1thgA:
undetectable		 3gy3A-1thgA:
18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		8 HIS A  57
LEU A  99
ASP A 189
SER A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.43A 3gy3A-1ym0A:
36.0		 3gy3A-1ym0A:
39.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 HIS A 483
SER A 633
TRP A 655
GLY A 656
GLY A 667
 None
 0.63A 3gy3A-1zjkA:
28.8		 3gy3A-1zjkA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 368  A 901 (-4.0A)
368  A 901 (-2.8A)
368  A 901 (-1.4A)
None
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.24A 3gy3A-1zlrA:
12.6		 3gy3A-1zlrA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 SO4  A 301 (-3.8A)
None
SO4  A 301 (-2.8A)
None
None
 0.64A 3gy3A-2aipA:
34.7		 3gy3A-2aipA:
39.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-4.1A)
BEN  A 301 (-3.4A)
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.42A 3gy3A-2eekA:
40.6		 3gy3A-2eekA:
62.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
 0.53A 3gy3A-2ei8A:
35.7		 3gy3A-2ei8A:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		9 HIS A  57
LEU A  99
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 227
 None
 0.43A 3gy3A-2f91A:
36.4		 3gy3A-2f91A:
44.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 LEU A 843
ASP A 961
TRP A 842
GLY A 886
GLY A 888
 None
 1.10A 3gy3A-2fgeA:
undetectable		 3gy3A-2fgeA:
12.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00089
(Trypsin)
PF00089
(Trypsin) 		5 HIS B  57
SER C 195
TRP C 215
GLY C 216
GLY C 226
 None
 0.64A 3gy3A-2jetB:
14.4		 3gy3A-2jetB:
38.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 HIS A 314
LEU A  39
GLN A  46
GLY A  62
GLY A  94
 None
 1.20A 3gy3A-2obyA:
undetectable		 3gy3A-2obyA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS A  57
ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
BEN  A 245 (-3.0A)
BEN  A 245 (-4.4A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.40A 3gy3A-2oq5A:
14.2		 3gy3A-2oq5A:
37.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pka KALLIKREIN A
KALLIKREIN A

(Sus scrofa;
Sus scrofa) 		PF00089
(Trypsin)
PF00089
(Trypsin) 		5 HIS A  57
ASP B 189
SER B 195
TRP B 215
GLY B 216
 None
BEN  B   1 (-3.0A)
BEN  B   1 ( 4.0A)
None
BEN  B   1 (-3.5A)
 0.38A 3gy3A-2pkaA:
10.7		 3gy3A-2pkaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pks THROMBIN HEAVY CHAIN
FRAGMENT

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP C 229
SER C 235
TRP C 257
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.33A 3gy3A-2pksC:
11.8		 3gy3A-2pksC:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		9 HIS A  57
GLN A 174
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.69A 3gy3A-2psyA:
37.8		 3gy3A-2psyA:
47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS B 485
ASP B 631
SER B 637
TRP B 659
GLY B 660
GLY B 668
 None
 0.45A 3gy3A-2qy0B:
11.7		 3gy3A-2qy0B:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.32A 3gy3A-2r0lA:
17.9		 3gy3A-2r0lA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS U  57
ASP U 189
SER U 190
GLN U 192
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.48A 3gy3A-2r2wU:
14.9		 3gy3A-2r2wU:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS U  57
SER U 190
GLN U 192
SER U 195
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.65A 3gy3A-2r2wU:
14.9		 3gy3A-2r2wU:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		8 HIS S  57
ASP S 189
SER S 190
GLN S 192
SER S 195
TRP S 215
GLY S 216
GLY S 226
 None
 0.71A 3gy3A-2wpmS:
13.4		 3gy3A-2wpmS:
41.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS A  59
ASP A 203
SER A 204
SER A 209
TRP A 229
GLY A 230
GLY A 240
 None
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.33A 3gy3A-2zecA:
12.7		 3gy3A-2zecA:
40.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 LEU A 212
ASP A 236
SER A 174
GLY A 178
GLY A 238
 None
 1.18A 3gy3A-3ab4A:
undetectable		 3gy3A-3ab4A:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.33A 3gy3A-3beuA:
32.2		 3gy3A-3beuA:
36.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 216
GLY H 226
 0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.56A 3gy3A-3f6uH:
33.8		 3gy3A-3f6uH:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS B 490
ASP B 640
SER B 646
TRP B 668
GLY B 669
GLY B 679
 None
 0.48A 3gy3A-3govB:
34.7		 3gy3A-3govB:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gym PROSTASIN

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS A  57
ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.58A 3gy3A-3gymA:
34.5		 3gy3A-3gymA:
40.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		5 LEU A 755
SER A 877
GLN A 860
GLY A 689
GLY A 692
 None
None
None
SO4  A  16 ( 3.9A)
None
 1.20A 3gy3A-3k7dA:
undetectable		 3gy3A-3k7dA:
16.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS B  57
LEU B  99
ASP B 189
SER B 195
TRP B 215
GLY B 216
GLY B 226
 None
 0.48A 3gy3A-3r3gB:
32.8		 3gy3A-3r3gB:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		5 HIS A  56
ASP A 189
SER A 195
GLY A 212
GLY A 223
 None
 0.52A 3gy3A-3s69A:
33.8		 3gy3A-3s69A:
44.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		6 HIS A 836
ASP A 973
SER A 974
SER A 979
GLY A1000
GLY A1010
 None
 0.29A 3gy3A-3w94A:
36.8		 3gy3A-3w94A:
35.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		5 HIS A 268
ASP A 474
SER A 471
GLY A 455
GLY A 475
 FAD  A1493 (-4.0A)
None
FAD  A1493 (-2.7A)
FAD  A1493 (-3.5A)
None
 1.16A 3gy3A-4at0A:
undetectable		 3gy3A-4at0A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		6 HIS A 211
ASP A 356
GLN A 359
SER A 362
GLY A 383
GLY A 393
 0GJ  A1411 (-2.8A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.6A)
0GJ  A1411 (-1.4A)
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.62A 3gy3A-4bxwA:
32.7		 3gy3A-4bxwA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS A  41
ASP A 181
SER A 182
GLN A 184
GLY A 208
GLY A 218
 None
 0.30A 3gy3A-4dgjA:
36.7		 3gy3A-4dgjA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS A  41
ASP A 181
SER A 182
SER A 187
GLY A 208
GLY A 218
 None
 0.63A 3gy3A-4dgjA:
36.7		 3gy3A-4dgjA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius halys) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
 None
 0.61A 3gy3A-4e7nA:
12.8		 3gy3A-4e7nA:
41.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS H 483
ASP H 627
SER H 628
TRP H 655
GLY H 656
GLY H 667
 None
 0.59A 3gy3A-4fxgH:
32.8		 3gy3A-4fxgH:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS E 478
ASP E 639
SER E 645
TRP E 667
GLY E 668
GLY E 680
 None
 0.58A 3gy3A-4iw4E:
32.9		 3gy3A-4iw4E:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k8y KALLIKREIN-4

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 None
 0.43A 3gy3A-4k8yA:
36.6		 3gy3A-4k8yA:
40.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k8y KALLIKREIN-4

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A  99
ASP A 189
SER A 190
GLY A 216
GLY A 226
 None
 0.76A 3gy3A-4k8yA:
36.6		 3gy3A-4k8yA:
40.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk4 VESB PROTEASE

(Vibrio cholerae) 		PF00089
(Trypsin) 		5 HIS A  78
LEU A 122
TRP A 239
GLY A 240
GLY A 251
 None
 0.54A 3gy3A-4lk4A:
27.1		 3gy3A-4lk4A:
26.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		7 HIS A  42
ASP A 173
GLN A 176
SER A 179
TRP A 195
GLY A 196
GLY A 206
 None
 0.26A 3gy3A-4m7gA:
34.6		 3gy3A-4m7gA:
40.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nff KALLIKREIN-2

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
 0G6  A 301 (-2.7A)
0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
 0.63A 3gy3A-4nffA:
38.5		 3gy3A-4nffA:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		8 HIS A  57
GLN A 175
ASP A 189
SER A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
 3KM  A 900 ( 4.4A)
None
3KM  A 900 (-2.9A)
3KM  A 900 (-2.9A)
3KM  A 900 (-3.6A)
None
3KM  A 900 (-3.4A)
3KM  A 900 (-3.2A)
 0.50A 3gy3A-4r0iA:
37.2		 3gy3A-4r0iA:
40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		9 HIS A  57
LEU A  99
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.59A 3gy3A-4wwyA:
41.2		 3gy3A-4wwyA:
74.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ylq COAGULATION FACTOR
VII

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS H  57
ASP H 189
SER H 190
SER H 195
TRP H 215
GLY H 216
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.40A 3gy3A-4ylqH:
35.2		 3gy3A-4ylqH:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS E  57
ASP E 189
TRP E 215
GLY E 216
GLY E 226
 None
 0.44A 3gy3A-5brrE:
15.4		 3gy3A-5brrE:
37.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		5 HIS A 413
SER A 557
TRP A 577
GLY A 578
GLY A 588
 None
 0.74A 3gy3A-5eodA:
24.8		 3gy3A-5eodA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.42A 3gy3A-5f8zA:
17.2		 3gy3A-5f8zA:
41.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 5 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.56A 3gy3A-5gvtA:
11.9		 3gy3A-5gvtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 1.19A 3gy3A-5gvtA:
11.9		 3gy3A-5gvtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		5 HIS A 562
GLN A 557
ASP A 452
GLY A 403
GLY A 449
 FE  A 702 ( 3.4A)
None
None
None
None
 1.07A 3gy3A-5iheA:
undetectable		 3gy3A-5iheA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens) 		no annotation 7 HIS A  57
GLN A 175
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.62A 3gy3A-5ms3A:
38.3		 3gy3A-5ms3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		6 HIS B  58
LEU B 111
ASP B 214
SER B 220
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 ( 3.8A)
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.38A 3gy3A-5to3B:
16.2		 3gy3A-5to3B:
27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 7 HIS A 475
ASP A 626
SER A 627
SER A 632
TRP A 655
GLY A 656
GLY A 663
 None
 0.52A 3gy3A-5ubmA:
11.7		 3gy3A-5ubmA:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus) 		no annotation 5 HIS A  67
ASP A 200
SER A 206
GLY A 223
GLY A 234
 None
 0.69A 3gy3A-5xrfA:
13.3		 3gy3A-5xrfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zfh KALLIKREIN-7

(Mus musculus) 		no annotation 5 HIS A  57
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.40A 3gy3A-5zfhA:
37.1		 3gy3A-5zfhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 6 HIS B  57
ASP B 189
SER B 195
TRP B 215
GLY B 216
GLY B 226
 SO4  B 304 (-3.8A)
BEN  B 301 (-2.7A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
 0.31A 3gy3A-6b74B:
13.7		 3gy3A-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 5 LEU B  12
GLN B 623
TRP B 353
GLY B 329
GLY B 665
 None
 1.17A 3gy3A-6bywB:
undetectable		 3gy3A-6bywB:
undetectable