SIMILAR PATTERNS OF AMINO ACIDS FOR 3GWX_B_EPAB3_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b7f | PROTEIN (SXL-LETHALPROTEIN) (Drosophilamelanogaster) |
PF00076(RRM_1) | 5 | LEU A 272VAL A 257VAL A 215LEU A 218ILE A 222 | None | 0.88A | 3gwxB-1b7fA:undetectable | 3gwxB-1b7fA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d4v | TNF-RELATEDAPOPTOSIS INDUCINGLIGAND (Homo sapiens) |
PF00229(TNF) | 5 | PHE B 248LEU B 167VAL B 122ILE B 256MET B 223 | None | 1.02A | 3gwxB-1d4vB:undetectable | 3gwxB-1d4vB:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dg6 | APO2L/TNF-RELATEDAPOPOTIS INDUCINGLIGAND (TRAIL) (Homo sapiens) |
PF00229(TNF) | 5 | PHE A 248LEU A 167VAL A 122ILE A 256MET A 223 | None | 0.96A | 3gwxB-1dg6A:undetectable | 3gwxB-1dg6A:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzh | TUMOR SUPPRESSORP53-BINDING PROTEIN1 (Homo sapiens) |
no annotation | 5 | GLN B1949LEU B1872VAL B1919VAL B1874LEU B1892 | None | 1.05A | 3gwxB-1gzhB:0.0 | 3gwxB-1gzhB:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lxy | ARGININE DEIMINASE (Mycoplasmaarginini) |
PF02274(Amidinotransf) | 5 | LEU A 156ILE A 198LEU A 78VAL A 79LEU A 24 | None | 1.11A | 3gwxB-1lxyA:0.0 | 3gwxB-1lxyA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m1j | FIBRINOGEN ALPHASUBUNITFIBRINOGEN BETACHAINFIBRINOGEN GAMMACHAIN (Gallus gallus) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 5 | LEU A 211ARG B 137LEU A 95LEU B 130ILE C 67 | None | 1.07A | 3gwxB-1m1jA:undetectable | 3gwxB-1m1jA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qas | PHOSPHOLIPASE CDELTA-1 (Rattusnorvegicus) |
PF00168(C2)PF00387(PI-PLC-Y)PF00388(PI-PLC-X)PF09279(EF-hand_like) | 5 | GLN A 671ILE A 675VAL A 750VAL A 733LEU A 735 | None | 1.09A | 3gwxB-1qasA:0.0 | 3gwxB-1qasA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qax | PROTEIN(3-HYDROXY-3-METHYLGLUTARYL-COENZYME AREDUCTASE) (Pseudomonasmevalonii) |
PF00368(HMG-CoA_red) | 5 | LEU A 26GLN A 69VAL A 64LEU A 345ILE A 356 | None | 1.10A | 3gwxB-1qaxA:0.1 | 3gwxB-1qaxA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdn | PROTEIN(N-ETHYLMALEIMIDESENSITIVE FUSIONPROTEIN (NSF)) (Cricetulusgriseus) |
PF02359(CDC48_N)PF02933(CDC48_2) | 5 | LEU A 18PHE A 101ILE A 196LEU A 147ILE A 99 | None | 1.11A | 3gwxB-1qdnA:undetectable | 3gwxB-1qdnA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qlc | POSTSYNAPTIC DENSITYPROTEIN 95 (Rattusnorvegicus) |
PF00595(PDZ) | 5 | ILE A 194LEU A 241VAL A 239LEU A 220ILE A 189 | None | 1.07A | 3gwxB-1qlcA:undetectable | 3gwxB-1qlcA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xje | RIBONUCLEOTIDEREDUCTASE,B12-DEPENDENT (Thermotogamaritima) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC) | 5 | LEU A 23ARG A 85ILE A 360VAL A 44LEU A 94 | None | 1.05A | 3gwxB-1xjeA:undetectable | 3gwxB-1xjeA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zap | SECRETED ASPARTICPROTEINASE (Candidaalbicans) |
PF00026(Asp) | 5 | GLN A 168VAL A 126VAL A 140LEU A 144ILE A 150 | None | 1.08A | 3gwxB-1zapA:undetectable | 3gwxB-1zapA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2adc | POLYPYRIMIDINETRACT-BINDINGPROTEIN 1 (Homo sapiens) |
PF00076(RRM_1)PF13893(RRM_5) | 5 | LEU A 394GLN A 352VAL A 379VAL A 341LEU A 344 | None | 0.88A | 3gwxB-2adcA:undetectable | 3gwxB-2adcA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4q | RHAMNOLIPIDSBIOSYNTHESIS3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Pseudomonasaeruginosa) |
PF13561(adh_short_C2) | 5 | LEU A 115PHE A 121GLN A 125ILE A 185LEU A 169 | NAP A1901 (-4.7A)NoneNoneNoneNone | 1.12A | 3gwxB-2b4qA:undetectable | 3gwxB-2b4qA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bf6 | EXO-ALPHA-SIALIDASE (Clostridiumperfringens) |
PF13088(BNR_2) | 5 | ARG A 479ILE A 449VAL A 497VAL A 542ILE A 332 | None | 1.03A | 3gwxB-2bf6A:undetectable | 3gwxB-2bf6A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpw | HYPOTHETICAL PROTEINTTHA0179 (Thermusthermophilus) |
PF12804(NTP_transf_3) | 5 | LEU A 47VAL A 105VAL A 102LEU A 97ILE A 94 | None | 1.09A | 3gwxB-2dpwA:undetectable | 3gwxB-2dpwA:26.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2epg | HYPOTHETICAL PROTEINTTHA1785 (Thermusthermophilus) |
PF01139(RtcB) | 5 | LEU A 176ILE A 55VAL A 92LEU A 283ILE A 274 | None | 1.13A | 3gwxB-2epgA:undetectable | 3gwxB-2epgA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f17 | THIAMINPYROPHOSPHOKINASE 1 (Mus musculus) |
PF04263(TPK_catalytic)PF04265(TPK_B1_binding) | 5 | LEU A 105ILE A 241LEU A 125VAL A 22LEU A 24 | NoneNoneNoneNoneAMP A 301 (-3.8A) | 1.12A | 3gwxB-2f17A:undetectable | 3gwxB-2f17A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f4o | PEPTIDE N-GLYCANASEXP-C REPAIRCOMPLEMENTINGCOMPLEX 58 KDAPROTEIN (Mus musculus) |
PF01841(Transglut_core)PF09280(XPC-binding) | 5 | LEU B 313LEU A 438VAL A 439LEU B 302ILE B 292 | None | 1.11A | 3gwxB-2f4oB:undetectable | 3gwxB-2f4oB:13.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fuq | HEPARINASE IIPROTEIN (Pedobacterheparinus) |
PF07940(Hepar_II_III)PF16332(DUF4962) | 5 | ILE A 208MET A 207VAL A 181VAL A 177MET A 41 | None | 0.94A | 3gwxB-2fuqA:undetectable | 3gwxB-2fuqA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g85 | CHORISMATE SYNTHASE (Mycobacteriumtuberculosis) |
PF01264(Chorismate_synt) | 5 | LEU A 2LEU A 375VAL A 26VAL A 23ILE A 382 | None | 1.12A | 3gwxB-2g85A:undetectable | 3gwxB-2g85A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jx2 | NEGATIVE ELONGATIONFACTOR E (Homo sapiens) |
PF00076(RRM_1) | 5 | LEU A 53GLN A 88VAL A 44LEU A 67ILE A 64 | None | 1.12A | 3gwxB-2jx2A:undetectable | 3gwxB-2jx2A:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m9k | RNA-BINDING PROTEINWITH MULTIPLESPLICING 2 (Homo sapiens) |
PF00076(RRM_1) | 5 | LEU A 88VAL A 73VAL A 35LEU A 38ILE A 42 | None | 0.78A | 3gwxB-2m9kA:undetectable | 3gwxB-2m9kA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mqe | OMPA DOMAIN PROTEINTRANSMEMBRANEREGION-CONTAININGPROTEIN (Escherichiacoli) |
PF00691(OmpA) | 5 | ILE A 316LEU A 264VAL A 236VAL A 260LEU A 217 | None | 0.95A | 3gwxB-2mqeA:undetectable | 3gwxB-2mqeA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ntb | PECTINESTERASE A (Dickeyadadantii) |
PF01095(Pectinesterase) | 5 | GLN A 125ILE A 61VAL A 159LEU A 157ILE A 129 | None | 1.14A | 3gwxB-2ntbA:undetectable | 3gwxB-2ntbA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2odp | COMPLEMENT C2 (Homo sapiens) |
PF00089(Trypsin)PF00092(VWA) | 5 | GLN A 716ILE A 710LEU A 609VAL A 593LEU A 665 | None | 1.05A | 3gwxB-2odpA:undetectable | 3gwxB-2odpA:19.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p54 | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 247PHE A 273GLN A 277ILE A 317MET A 320VAL A 332LEU A 344 | None735 A 469 (-3.7A)735 A 469 (-4.4A)735 A 469 ( 4.8A)None735 A 469 (-3.8A)735 A 469 ( 4.2A) | 0.59A | 3gwxB-2p54A:38.0 | 3gwxB-2p54A:70.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3z | TRANSGLUTAMINASE 2 (Homo sapiens) |
PF00868(Transglut_N)PF00927(Transglut_C)PF01841(Transglut_core) | 5 | GLN A 270VAL A 228VAL A 283LEU A 261ILE A 192 | None | 0.99A | 3gwxB-2q3zA:undetectable | 3gwxB-2q3zA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v6g | PROGESTERONE5-BETA-REDUCTASE (Digitalislanata) |
PF01370(Epimerase) | 6 | LEU A 127ILE A 75LEU A 95VAL A 98VAL A 130LEU A 92 | None | 1.48A | 3gwxB-2v6gA:undetectable | 3gwxB-2v6gA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vbf | BRANCHED-CHAINALPHA-KETOACIDDECARBOXYLASE (Lactococcuslactis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 333LEU A 279VAL A 324VAL A 216ILE A 236 | ILE A 333 ( 0.6A)LEU A 279 ( 0.6A)VAL A 324 ( 0.6A)VAL A 216 ( 0.6A)ILE A 236 ( 0.6A) | 1.08A | 3gwxB-2vbfA:undetectable | 3gwxB-2vbfA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wbe | BIPOLAR KINESINKRP-130 (Drosophilamelanogaster) |
PF00225(Kinesin) | 5 | LEU C 147GLN C 306ILE C 284LEU C 250VAL C 248 | None | 1.09A | 3gwxB-2wbeC:undetectable | 3gwxB-2wbeC:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtb | FATTY ACIDMULTIFUNCTIONALPROTEIN (ATMFP2) (Arabidopsisthaliana) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ILE A 327LEU A 476VAL A 446VAL A 472ILE A 312 | None | 1.05A | 3gwxB-2wtbA:undetectable | 3gwxB-2wtbA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wy4 | SINGLE DOMAINHAEMOGLOBIN (Campylobacterjejuni) |
PF00042(Globin) | 5 | GLN A 5ILE A 126LEU A 16LEU A 109ILE A 105 | NoneHEM A 150 ( 4.8A)NoneNoneNone | 1.10A | 3gwxB-2wy4A:undetectable | 3gwxB-2wy4A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x30 | PHOSPHORIBOSYLISOMERASE A (Streptomycescoelicolor) |
PF00977(His_biosynth) | 5 | LEU A 181ILE A 125VAL A 193VAL A 185LEU A 152 | None | 1.07A | 3gwxB-2x30A:undetectable | 3gwxB-2x30A:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xwu | IMPORTIN13 (Homo sapiens) |
PF03810(IBN_N)PF08389(Xpo1) | 5 | PHE B 897LEU B 870VAL B 869LEU B 889ILE B 930 | None | 1.06A | 3gwxB-2xwuB:undetectable | 3gwxB-2xwuB:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ak5 | HEMOGLOBIN-BINDINGPROTEASE HBP (Escherichiacoli) |
PF02395(Peptidase_S6) | 5 | LEU A 335GLN A 412VAL A 373LEU A 380ILE A 401 | None | 1.07A | 3gwxB-3ak5A:undetectable | 3gwxB-3ak5A:14.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b0q | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 255PHE A 282GLN A 286ILE A 326MET A 329LEU A 353 | NoneMC5 A 1 (-4.4A)NoneMC5 A 1 ( 4.9A)NoneMC5 A 1 (-4.7A) | 0.69A | 3gwxB-3b0qA:36.6 | 3gwxB-3b0qA:61.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b6v | KINESIN-LIKE PROTEINKIF3C (Homo sapiens) |
PF00225(Kinesin) | 5 | LEU A 146GLN A 327ILE A 304LEU A 247VAL A 245 | None | 1.05A | 3gwxB-3b6vA:undetectable | 3gwxB-3b6vA:21.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d5f | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR DELTA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | LEU A 255PHE A 282ARG A 284GLN A 286ILE A 326MET A 329LEU A 339VAL A 341VAL A 348LEU A 353ILE A 364MET A 453 | NoneL41 A 501 ( 4.9A)NoneNoneNoneNoneL41 A 501 (-4.8A)L41 A 501 ( 4.4A)NoneNoneL41 A 501 ( 4.2A)L41 A 501 ( 3.7A) | 0.71A | 3gwxB-3d5fA:38.2 | 3gwxB-3d5fA:99.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d5f | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR DELTA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | PHE A 360LEU A 339VAL A 341VAL A 348LEU A 353ILE A 364 | NoneL41 A 501 (-4.8A)L41 A 501 ( 4.4A)NoneNoneL41 A 501 ( 4.2A) | 1.25A | 3gwxB-3d5fA:38.2 | 3gwxB-3d5fA:99.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 6 | LEU D 255PHE D 282GLN D 286ILE D 326MET D 329LEU D 353 | NoneNoneNonePLB D 701 ( 4.5A)NoneNone | 0.72A | 3gwxB-3dzuD:34.4 | 3gwxB-3dzuD:42.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzz | PUTATIVE PYRIDOXAL5'-PHOSPHATE-DEPENDENT C-S LYASE (Lactobacillusdelbrueckii) |
PF00155(Aminotran_1_2) | 5 | LEU A 341PHE A 362VAL A 309VAL A 385LEU A 330 | None | 1.06A | 3gwxB-3dzzA:undetectable | 3gwxB-3dzzA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7o | MITOGEN-ACTIVATEDPROTEIN KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 5 | ARG A 127ILE A 321LEU A 165VAL A 159LEU A 115 | None | 1.10A | 3gwxB-3e7oA:undetectable | 3gwxB-3e7oA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eay | SENTRIN-SPECIFICPROTEASE 7 (Homo sapiens) |
PF02902(Peptidase_C48) | 5 | LEU A 701ILE A 737LEU A 694VAL A 713VAL A 696 | None | 1.13A | 3gwxB-3eayA:undetectable | 3gwxB-3eayA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ein | GLUTATHIONES-TRANSFERASE 1-1 (Drosophilamelanogaster) |
PF00043(GST_C)PF02798(GST_N) | 6 | ILE A 158LEU A 27VAL A 25VAL A 2LEU A 56ILE A 69 | None | 1.24A | 3gwxB-3einA:undetectable | 3gwxB-3einA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f95 | BETA-GLUCOSIDASE (Pseudoalteromonassp. BB1) |
no annotation | 5 | ARG A 743GLN A 733LEU A 798LEU A 707ILE A 778 | None | 1.04A | 3gwxB-3f95A:undetectable | 3gwxB-3f95A:24.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8b | XYLULOSE KINASE (Bifidobacteriumadolescentis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | LEU A 406ILE A 485LEU A 447ILE A 427MET A 283 | None | 1.12A | 3gwxB-3i8bA:undetectable | 3gwxB-3i8bA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iyl | VP1 (Aquareovirus C) |
PF06016(Reovirus_L2) | 5 | LEU W 657VAL W 620VAL W 655LEU W 644ILE W 445 | None | 1.10A | 3gwxB-3iylW:undetectable | 3gwxB-3iylW:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jav | INOSITOL1,4,5-TRISPHOSPHATERECEPTOR TYPE 1 (Rattusnorvegicus) |
PF00520(Ion_trans)PF01365(RYDR_ITPR)PF02815(MIR)PF08454(RIH_assoc)PF08709(Ins145_P3_rec) | 5 | PHE A 161GLN A 122ILE A 14MET A 224VAL A 114 | None | 1.11A | 3gwxB-3javA:undetectable | 3gwxB-3javA:7.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kt9 | APRATAXIN (Homo sapiens) |
PF00498(FHA) | 5 | LEU A 19GLN A 44VAL A 98LEU A 81ILE A 68 | None | 1.03A | 3gwxB-3kt9A:undetectable | 3gwxB-3kt9A:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lhk | PUTATIVE DNA BINDINGPROTEIN MJ0014 (Methanocaldococcusjannaschii) |
PF00239(Resolvase) | 5 | ILE A 97LEU A 117VAL A 121LEU A 137ILE A 131 | None | 1.11A | 3gwxB-3lhkA:undetectable | 3gwxB-3lhkA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3op7 | AMINOTRANSFERASECLASS I AND II (Streptococcussuis) |
PF00155(Aminotran_1_2) | 5 | GLN A 365ILE A 357LEU A 347VAL A 345LEU A 333 | None | 1.09A | 3gwxB-3op7A:undetectable | 3gwxB-3op7A:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ow8 | WD REPEAT-CONTAININGPROTEIN 61 (Homo sapiens) |
PF00400(WD40) | 5 | PHE A 9GLN A 11VAL A 277VAL A 256ILE A 7 | None | 1.07A | 3gwxB-3ow8A:undetectable | 3gwxB-3ow8A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p4g | ANTIFREEZE PROTEIN (Marinomonasprimoryensis) |
no annotation | 5 | LEU A 282ARG A 299VAL A 246VAL A 263LEU A 261 | None | 1.03A | 3gwxB-3p4gA:undetectable | 3gwxB-3p4gA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qe7 | URACIL PERMEASE (Escherichiacoli) |
PF00860(Xan_ur_permease) | 5 | LEU A 91GLN A 327LEU A 80VAL A 79LEU A 83 | None | 1.14A | 3gwxB-3qe7A:undetectable | 3gwxB-3qe7A:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgk | FUSION OF UREASEBETA AND GAMMASUBUNITS (Helicobactermustelae) |
PF00547(Urease_gamma)PF00699(Urease_beta) | 5 | ILE A 224LEU A 129VAL A 131VAL A 184LEU A 186 | None | 1.02A | 3gwxB-3qgkA:undetectable | 3gwxB-3qgkA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qtp | ENOLASE 1 (Entamoebahistolytica) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | PHE A 358ILE A 385VAL A 344VAL A 332ILE A 351 | None | 1.14A | 3gwxB-3qtpA:undetectable | 3gwxB-3qtpA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rit | DIPEPTIDE EPIMERASE (Methylococcuscapsulatus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 210LEU A 159VAL A 161VAL A 187LEU A 181 | None | 1.06A | 3gwxB-3ritA:undetectable | 3gwxB-3ritA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rre | PUTATIVEUNCHARACTERIZEDPROTEIN (Thermotogamaritima) |
PF01256(Carb_kinase)PF03853(YjeF_N) | 5 | LEU A 106ILE A 152VAL A 143VAL A 112ILE A 116 | None | 0.91A | 3gwxB-3rreA:undetectable | 3gwxB-3rreA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sl1 | ARGINASE (Plasmodiumfalciparum) |
PF00491(Arginase) | 6 | LEU A 187ILE A 310LEU A 355VAL A 361VAL A 405ILE A 215 | None | 1.34A | 3gwxB-3sl1A:undetectable | 3gwxB-3sl1A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t1u | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Azotobactervinelandii) |
PF00160(Pro_isomerase) | 5 | GLN A 97ILE A 68VAL A 31LEU A 13ILE A 83 | None | 1.14A | 3gwxB-3t1uA:undetectable | 3gwxB-3t1uA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6c | PUTATIVE MAND FAMILYDEHYDRATASE (Pantoeaananatis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 305VAL A 24VAL A 9LEU A 60ILE A 71 | None | 1.14A | 3gwxB-3t6cA:undetectable | 3gwxB-3t6cA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3trc | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Coxiellaburnetii) |
PF01590(GAF) | 5 | LEU A 7ILE A 44MET A 55VAL A 27ILE A 115 | None | 1.13A | 3gwxB-3trcA:undetectable | 3gwxB-3trcA:25.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txv | PROBABLE TAGATOSE6-PHOSPHATE KINASE (Sinorhizobiummeliloti) |
PF08013(Tagatose_6_P_K) | 5 | LEU A 300ILE A 50LEU A 292VAL A 415MET A 66 | None | 1.03A | 3gwxB-3txvA:undetectable | 3gwxB-3txvA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4g | NAMN:DMBPHOSPHORIBOSYLTRANSFERASE (Pyrococcushorikoshii) |
no annotation | 5 | LEU A 124LEU A 81VAL A 96LEU A 129ILE A 132 | None | 1.12A | 3gwxB-3u4gA:undetectable | 3gwxB-3u4gA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uan | HEPARAN SULFATEGLUCOSAMINE3-O-SULFOTRANSFERASE1 (Mus musculus) |
PF00685(Sulfotransfer_1) | 6 | GLN A 60ILE A 137VAL A 219LEU A 74ILE A 63MET A 111 | None | 1.27A | 3gwxB-3uanA:undetectable | 3gwxB-3uanA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wyf | GSP1P (Saccharomycescerevisiae) |
PF00071(Ras) | 5 | GLN A 147ILE A 151LEU A 17VAL A 16ILE A 90 | None | 1.10A | 3gwxB-3wyfA:undetectable | 3gwxB-3wyfA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zto | NUCLEOSIDEDIPHOSPHATE KINASE (Aquifexaeolicus) |
PF00334(NDK) | 5 | ILE A 89VAL A 10VAL A 73LEU A 37ILE A 34 | None | 0.96A | 3gwxB-3ztoA:undetectable | 3gwxB-3ztoA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cob | KYNURENINEFORMAMIDASE (Pseudomonasaeruginosa) |
PF04199(Cyclase) | 5 | ARG A 138VAL A 140VAL A 108LEU A 110ILE A 127 | None | 1.08A | 3gwxB-4cobA:undetectable | 3gwxB-4cobA:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecd | CHORISMATE SYNTHASE (Bifidobacteriumlongum) |
PF01264(Chorismate_synt) | 5 | GLN A 307VAL A 225VAL A 359LEU A 363ILE A 160 | None | 1.08A | 3gwxB-4ecdA:undetectable | 3gwxB-4ecdA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4flc | ADENYLOSUCCINATELYASE (Homo sapiens) |
PF00206(Lyase_1)PF10397(ADSL_C) | 5 | ILE A 351LEU A 186VAL A 254VAL A 189LEU A 128 | None | 1.02A | 3gwxB-4flcA:undetectable | 3gwxB-4flcA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gs5 | ACYL-COA SYNTHETASE(AMP-FORMING)/AMP-ACID LIGASE II-LIKEPROTEIN (Dyadobacterfermentans) |
PF00501(AMP-binding) | 5 | LEU A 152MET A 1LEU A 79VAL A 124LEU A 147 | None | 1.12A | 3gwxB-4gs5A:undetectable | 3gwxB-4gs5A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h0m | C-PHYCOCYANIN ALPHACHAINC-PHYCOCYANIN BETACHAIN (Synechococcuselongatus) |
PF00502(Phycobilisome) | 5 | LEU B 30ILE A 94LEU B 19VAL B 8LEU A 38 | None | 1.00A | 3gwxB-4h0mB:undetectable | 3gwxB-4h0mB:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ihc | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Dickeyaparadisiaca) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 305VAL A 24VAL A 9LEU A 60ILE A 71 | None | 1.14A | 3gwxB-4ihcA:undetectable | 3gwxB-4ihcA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4io6 | AVGLUR1 LIGANDBINDING DOMAIN (Adineta vaga) |
PF00497(SBP_bac_3) | 5 | LEU A 60PHE A 20ILE A 225VAL A 58LEU A 42 | None | 1.07A | 3gwxB-4io6A:undetectable | 3gwxB-4io6A:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l9o | SEC16,PROTEINTRANSPORT PROTEINSEC13 (Komagataellapastoris;Komagataellaphaffii) |
PF00400(WD40) | 5 | ARG A2034ILE A1073VAL A2057LEU A2060ILE A2044 | EDO A2409 ( 4.0A)NoneNoneNoneNone | 1.02A | 3gwxB-4l9oA:undetectable | 3gwxB-4l9oA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m4d | LIPOPOLYSACCHARIDE-BINDING PROTEIN (Mus musculus) |
PF01273(LBP_BPI_CETP)PF02886(LBP_BPI_CETP_C) | 5 | PHE A 469ILE A 348LEU A 391VAL A 398LEU A 472 | None | 1.10A | 3gwxB-4m4dA:undetectable | 3gwxB-4m4dA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u28 | PHOSPHORIBOSYLISOMERASE A (Streptomycessviceus) |
PF00977(His_biosynth) | 5 | LEU A 185ILE A 129VAL A 197VAL A 189LEU A 156 | None | 1.13A | 3gwxB-4u28A:undetectable | 3gwxB-4u28A:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud8 | FAD-BINDING AND BBEDOMAIN-CONTAININGPROTEIN (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | LEU A 108LEU A 245VAL A 213VAL A 243LEU A 135 | NoneNoneNoneFAD A 601 ( 4.2A)FAD A 601 (-4.7A) | 0.94A | 3gwxB-4ud8A:undetectable | 3gwxB-4ud8A:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uug | AMINE TRANSAMINASE (Aspergillusfumigatus) |
PF01063(Aminotran_4) | 5 | LEU A 203PHE A 174GLN A 182ILE A 117MET A 85 | NoneNoneNoneNoneFMT A 405 (-4.7A) | 1.01A | 3gwxB-4uugA:undetectable | 3gwxB-4uugA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v2d | FIBRONECTIN LEUCINERICH TRANSMEMBRANEPROTEIN 2 (Homo sapiens) |
PF01463(LRRCT)PF13855(LRR_8) | 5 | LEU A 291GLN A 304VAL A 350VAL A 321ILE A 328 | None | 1.13A | 3gwxB-4v2dA:undetectable | 3gwxB-4v2dA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x2r | 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO]IMIDAZOLE-4-CARBOXAMIDE ISOMERASE (Actinomycesurogenitalis) |
PF00977(His_biosynth) | 5 | LEU A 179ILE A 123VAL A 191VAL A 183LEU A 150 | None | 1.01A | 3gwxB-4x2rA:undetectable | 3gwxB-4x2rA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9s | PHOSPHORIBOSYLISOMERASE A (Streptomycessp. Mg1) |
PF00977(His_biosynth) | 5 | LEU A 183ILE A 127VAL A 195VAL A 187LEU A 154 | None | 1.12A | 3gwxB-4x9sA:undetectable | 3gwxB-4x9sA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxs | VIRION EGRESSPROTEIN UL31VIRION EGRESSPROTEIN UL34 (Humanalphaherpesvirus1) |
PF02718(Herpes_UL31)PF04541(Herpes_U34) | 5 | PHE B 243ILE A 119LEU B 116VAL B 92ILE B 231 | NoneNoneNoneNone NA B 402 (-3.8A) | 1.12A | 3gwxB-4zxsB:undetectable | 3gwxB-4zxsB:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6g | AGR133CPSISTER CHROMATIDCOHESION PROTEIN 2 (Eremotheciumgossypii) |
PF10345(Cohesin_load)no annotation | 5 | LEU A 368ILE A 277LEU B 36VAL A 391LEU A 324 | None | 0.95A | 3gwxB-5c6gA:undetectable | 3gwxB-5c6gA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cdi | CHAPERONIN 60B1 (Chlamydomonasreinhardtii) |
PF00118(Cpn60_TCP1) | 5 | ARG A 506GLN A 126ILE A 446VAL A 505VAL A 413 | None | 0.97A | 3gwxB-5cdiA:undetectable | 3gwxB-5cdiA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9x | BETA-1,3-GLUCANASE (Paenibacillusbarengoltzii) |
PF16483(Glyco_hydro_64) | 5 | LEU A 407ILE A 131LEU A 198VAL A 235LEU A 415 | None | 1.09A | 3gwxB-5h9xA:undetectable | 3gwxB-5h9xA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hnp | ABC TRANSPORTER (Raoultellaornithinolytica) |
PF14524(Wzt_C) | 5 | ILE A 380VAL A 276LEU A 281ILE A 304MET A 416 | None | 1.14A | 3gwxB-5hnpA:undetectable | 3gwxB-5hnpA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5htk | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 2 (Homo sapiens) |
PF00300(His_Phos_1)PF01591(6PF2K) | 5 | LEU A 213ARG A 137LEU A 40VAL A 42VAL A 151 | None | 1.10A | 3gwxB-5htkA:undetectable | 3gwxB-5htkA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2g | DIOL DEHYDRATASE (Roseburiainulinivorans) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | LEU A 530PHE A 271GLN A 267VAL A 182ILE A 218 | None | 1.13A | 3gwxB-5i2gA:undetectable | 3gwxB-5i2gA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j44 | SERINE PROTEASE SEPAAUTOTRANSPORTER (Shigellaflexneri) |
PF02395(Peptidase_S6) | 5 | LEU A 283GLN A 360VAL A 321LEU A 328ILE A 349 | None | 1.07A | 3gwxB-5j44A:undetectable | 3gwxB-5j44A:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ken | EBOLA SURFACEGLYCOPROTEIN, GP1EBOLA SURFACEGLYCOPROTEIN, GP2 (Zaireebolavirus) |
PF01611(Filo_glycop)no annotation | 5 | LEU A 68GLN B 551VAL A 66LEU A 184ILE A 38 | None | 1.09A | 3gwxB-5kenA:undetectable | 3gwxB-5kenA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kui | CALCIUM UNIPORTERPROTEIN,MITOCHONDRIAL (Homo sapiens) |
no annotation | 5 | GLN A 114ILE A 122VAL A 75VAL A 160ILE A 127 | None | 1.05A | 3gwxB-5kuiA:undetectable | 3gwxB-5kuiA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5liq | NICKING ENDONUCLEASEN.BSPD6I (Bacillus sp.(in: Bacteria)) |
PF09491(RE_AlwI) | 5 | ILE A 535LEU A 545VAL A 548LEU A 559ILE A 564 | None | 1.00A | 3gwxB-5liqA:undetectable | 3gwxB-5liqA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msw | THIOESTER REDUCTASEDOMAIN-CONTAININGPROTEIN (Segniliparusrugosus) |
PF00501(AMP-binding)PF00550(PP-binding) | 5 | LEU A 19PHE A 294ILE A 361LEU A 423VAL A 401 | None | 1.14A | 3gwxB-5mswA:undetectable | 3gwxB-5mswA:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mzo | UDP-GLUCOSE-GLYCOPROTEINGLUCOSYLTRANSFERASE-LIKE PROTEIN (Chaetomiumthermophilum) |
PF06427(UDP-g_GGTase) | 6 | LEU A 431GLN A 580ILE A 511VAL A 472VAL A 483LEU A 533 | None | 1.29A | 3gwxB-5mzoA:undetectable | 3gwxB-5mzoA:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nit | GLUCOSE OXIDASE (Aspergillusniger) |
no annotation | 5 | ARG A 545GLN A 542VAL A 532LEU A 298ILE A 303 | None | 1.10A | 3gwxB-5nitA:undetectable | 3gwxB-5nitA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o6k | POLYPHOSPHATE:AMPPHOSPHOTRANSFERASE (Meiothermusruber) |
no annotation | 5 | LEU A 168PHE A 120LEU A 243VAL A 77VAL A 239 | None | 0.90A | 3gwxB-5o6kA:undetectable | 3gwxB-5o6kA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tse | LPS-ASSEMBLYLIPOPROTEIN LPTE (Acinetobacterbaumannii) |
no annotation | 5 | GLN A 153VAL A 102VAL A 79LEU A 77ILE A 159 | None | 0.97A | 3gwxB-5tseA:undetectable | 3gwxB-5tseA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vi6 | HISTONE DEACETYLASE8 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | ILE A 284LEU A 248VAL A 247VAL A 251LEU A 173 | None | 0.91A | 3gwxB-5vi6A:undetectable | 3gwxB-5vi6A:21.72 |