SIMILAR PATTERNS OF AMINO ACIDS FOR 3GWX_B_EPAB3_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7f PROTEIN (SXL-LETHAL
PROTEIN)


(Drosophila
melanogaster)
PF00076
(RRM_1)
5 LEU A 272
VAL A 257
VAL A 215
LEU A 218
ILE A 222
None
0.88A 3gwxB-1b7fA:
undetectable
3gwxB-1b7fA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4v TNF-RELATED
APOPTOSIS INDUCING
LIGAND


(Homo sapiens)
PF00229
(TNF)
5 PHE B 248
LEU B 167
VAL B 122
ILE B 256
MET B 223
None
1.02A 3gwxB-1d4vB:
undetectable
3gwxB-1d4vB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dg6 APO2L/TNF-RELATED
APOPOTIS INDUCING
LIGAND (TRAIL)


(Homo sapiens)
PF00229
(TNF)
5 PHE A 248
LEU A 167
VAL A 122
ILE A 256
MET A 223
None
0.96A 3gwxB-1dg6A:
undetectable
3gwxB-1dg6A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1


(Homo sapiens)
no annotation 5 GLN B1949
LEU B1872
VAL B1919
VAL B1874
LEU B1892
None
1.05A 3gwxB-1gzhB:
0.0
3gwxB-1gzhB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini)
PF02274
(Amidinotransf)
5 LEU A 156
ILE A 198
LEU A  78
VAL A  79
LEU A  24
None
1.11A 3gwxB-1lxyA:
0.0
3gwxB-1lxyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN


(Gallus gallus)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
5 LEU A 211
ARG B 137
LEU A  95
LEU B 130
ILE C  67
None
1.07A 3gwxB-1m1jA:
undetectable
3gwxB-1m1jA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qas PHOSPHOLIPASE C
DELTA-1


(Rattus
norvegicus)
PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like)
5 GLN A 671
ILE A 675
VAL A 750
VAL A 733
LEU A 735
None
1.09A 3gwxB-1qasA:
0.0
3gwxB-1qasA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)


(Pseudomonas
mevalonii)
PF00368
(HMG-CoA_red)
5 LEU A  26
GLN A  69
VAL A  64
LEU A 345
ILE A 356
None
1.10A 3gwxB-1qaxA:
0.1
3gwxB-1qaxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdn PROTEIN
(N-ETHYLMALEIMIDE
SENSITIVE FUSION
PROTEIN (NSF))


(Cricetulus
griseus)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
5 LEU A  18
PHE A 101
ILE A 196
LEU A 147
ILE A  99
None
1.11A 3gwxB-1qdnA:
undetectable
3gwxB-1qdnA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlc POSTSYNAPTIC DENSITY
PROTEIN 95


(Rattus
norvegicus)
PF00595
(PDZ)
5 ILE A 194
LEU A 241
VAL A 239
LEU A 220
ILE A 189
None
1.07A 3gwxB-1qlcA:
undetectable
3gwxB-1qlcA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT


(Thermotoga
maritima)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
5 LEU A  23
ARG A  85
ILE A 360
VAL A  44
LEU A  94
None
1.05A 3gwxB-1xjeA:
undetectable
3gwxB-1xjeA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE


(Candida
albicans)
PF00026
(Asp)
5 GLN A 168
VAL A 126
VAL A 140
LEU A 144
ILE A 150
None
1.08A 3gwxB-1zapA:
undetectable
3gwxB-1zapA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1


(Homo sapiens)
PF00076
(RRM_1)
PF13893
(RRM_5)
5 LEU A 394
GLN A 352
VAL A 379
VAL A 341
LEU A 344
None
0.88A 3gwxB-2adcA:
undetectable
3gwxB-2adcA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4q RHAMNOLIPIDS
BIOSYNTHESIS
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Pseudomonas
aeruginosa)
PF13561
(adh_short_C2)
5 LEU A 115
PHE A 121
GLN A 125
ILE A 185
LEU A 169
NAP  A1901 (-4.7A)
None
None
None
None
1.12A 3gwxB-2b4qA:
undetectable
3gwxB-2b4qA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens)
PF13088
(BNR_2)
5 ARG A 479
ILE A 449
VAL A 497
VAL A 542
ILE A 332
None
1.03A 3gwxB-2bf6A:
undetectable
3gwxB-2bf6A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpw HYPOTHETICAL PROTEIN
TTHA0179


(Thermus
thermophilus)
PF12804
(NTP_transf_3)
5 LEU A  47
VAL A 105
VAL A 102
LEU A  97
ILE A  94
None
1.09A 3gwxB-2dpwA:
undetectable
3gwxB-2dpwA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785


(Thermus
thermophilus)
PF01139
(RtcB)
5 LEU A 176
ILE A  55
VAL A  92
LEU A 283
ILE A 274
None
1.13A 3gwxB-2epgA:
undetectable
3gwxB-2epgA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f17 THIAMIN
PYROPHOSPHOKINASE 1


(Mus musculus)
PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding)
5 LEU A 105
ILE A 241
LEU A 125
VAL A  22
LEU A  24
None
None
None
None
AMP  A 301 (-3.8A)
1.12A 3gwxB-2f17A:
undetectable
3gwxB-2f17A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE
XP-C REPAIR
COMPLEMENTING
COMPLEX 58 KDA
PROTEIN


(Mus musculus)
PF01841
(Transglut_core)
PF09280
(XPC-binding)
5 LEU B 313
LEU A 438
VAL A 439
LEU B 302
ILE B 292
None
1.11A 3gwxB-2f4oB:
undetectable
3gwxB-2f4oB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN


(Pedobacter
heparinus)
PF07940
(Hepar_II_III)
PF16332
(DUF4962)
5 ILE A 208
MET A 207
VAL A 181
VAL A 177
MET A  41
None
0.94A 3gwxB-2fuqA:
undetectable
3gwxB-2fuqA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis)
PF01264
(Chorismate_synt)
5 LEU A   2
LEU A 375
VAL A  26
VAL A  23
ILE A 382
None
1.12A 3gwxB-2g85A:
undetectable
3gwxB-2g85A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jx2 NEGATIVE ELONGATION
FACTOR E


(Homo sapiens)
PF00076
(RRM_1)
5 LEU A  53
GLN A  88
VAL A  44
LEU A  67
ILE A  64
None
1.12A 3gwxB-2jx2A:
undetectable
3gwxB-2jx2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9k RNA-BINDING PROTEIN
WITH MULTIPLE
SPLICING 2


(Homo sapiens)
PF00076
(RRM_1)
5 LEU A  88
VAL A  73
VAL A  35
LEU A  38
ILE A  42
None
0.78A 3gwxB-2m9kA:
undetectable
3gwxB-2m9kA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqe OMPA DOMAIN PROTEIN
TRANSMEMBRANE
REGION-CONTAINING
PROTEIN


(Escherichia
coli)
PF00691
(OmpA)
5 ILE A 316
LEU A 264
VAL A 236
VAL A 260
LEU A 217
None
0.95A 3gwxB-2mqeA:
undetectable
3gwxB-2mqeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii)
PF01095
(Pectinesterase)
5 GLN A 125
ILE A  61
VAL A 159
LEU A 157
ILE A 129
None
1.14A 3gwxB-2ntbA:
undetectable
3gwxB-2ntbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens)
PF00089
(Trypsin)
PF00092
(VWA)
5 GLN A 716
ILE A 710
LEU A 609
VAL A 593
LEU A 665
None
1.05A 3gwxB-2odpA:
undetectable
3gwxB-2odpA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 247
PHE A 273
GLN A 277
ILE A 317
MET A 320
VAL A 332
LEU A 344
None
735  A 469 (-3.7A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
None
735  A 469 (-3.8A)
735  A 469 ( 4.2A)
0.59A 3gwxB-2p54A:
38.0
3gwxB-2p54A:
70.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens)
PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core)
5 GLN A 270
VAL A 228
VAL A 283
LEU A 261
ILE A 192
None
0.99A 3gwxB-2q3zA:
undetectable
3gwxB-2q3zA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6g PROGESTERONE
5-BETA-REDUCTASE


(Digitalis
lanata)
PF01370
(Epimerase)
6 LEU A 127
ILE A  75
LEU A  95
VAL A  98
VAL A 130
LEU A  92
None
1.48A 3gwxB-2v6gA:
undetectable
3gwxB-2v6gA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE


(Lactococcus
lactis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ILE A 333
LEU A 279
VAL A 324
VAL A 216
ILE A 236
ILE  A 333 ( 0.6A)
LEU  A 279 ( 0.6A)
VAL  A 324 ( 0.6A)
VAL  A 216 ( 0.6A)
ILE  A 236 ( 0.6A)
1.08A 3gwxB-2vbfA:
undetectable
3gwxB-2vbfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130


(Drosophila
melanogaster)
PF00225
(Kinesin)
5 LEU C 147
GLN C 306
ILE C 284
LEU C 250
VAL C 248
None
1.09A 3gwxB-2wbeC:
undetectable
3gwxB-2wbeC:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)


(Arabidopsis
thaliana)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 ILE A 327
LEU A 476
VAL A 446
VAL A 472
ILE A 312
None
1.05A 3gwxB-2wtbA:
undetectable
3gwxB-2wtbA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy4 SINGLE DOMAIN
HAEMOGLOBIN


(Campylobacter
jejuni)
PF00042
(Globin)
5 GLN A   5
ILE A 126
LEU A  16
LEU A 109
ILE A 105
None
HEM  A 150 ( 4.8A)
None
None
None
1.10A 3gwxB-2wy4A:
undetectable
3gwxB-2wy4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x30 PHOSPHORIBOSYL
ISOMERASE A


(Streptomyces
coelicolor)
PF00977
(His_biosynth)
5 LEU A 181
ILE A 125
VAL A 193
VAL A 185
LEU A 152
None
1.07A 3gwxB-2x30A:
undetectable
3gwxB-2x30A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens)
PF03810
(IBN_N)
PF08389
(Xpo1)
5 PHE B 897
LEU B 870
VAL B 869
LEU B 889
ILE B 930
None
1.06A 3gwxB-2xwuB:
undetectable
3gwxB-2xwuB:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP


(Escherichia
coli)
PF02395
(Peptidase_S6)
5 LEU A 335
GLN A 412
VAL A 373
LEU A 380
ILE A 401
None
1.07A 3gwxB-3ak5A:
undetectable
3gwxB-3ak5A:
14.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 255
PHE A 282
GLN A 286
ILE A 326
MET A 329
LEU A 353
None
MC5  A   1 (-4.4A)
None
MC5  A   1 ( 4.9A)
None
MC5  A   1 (-4.7A)
0.69A 3gwxB-3b0qA:
36.6
3gwxB-3b0qA:
61.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C


(Homo sapiens)
PF00225
(Kinesin)
5 LEU A 146
GLN A 327
ILE A 304
LEU A 247
VAL A 245
None
1.05A 3gwxB-3b6vA:
undetectable
3gwxB-3b6vA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA


(Homo sapiens)
PF00104
(Hormone_recep)
12 LEU A 255
PHE A 282
ARG A 284
GLN A 286
ILE A 326
MET A 329
LEU A 339
VAL A 341
VAL A 348
LEU A 353
ILE A 364
MET A 453
None
L41  A 501 ( 4.9A)
None
None
None
None
L41  A 501 (-4.8A)
L41  A 501 ( 4.4A)
None
None
L41  A 501 ( 4.2A)
L41  A 501 ( 3.7A)
0.71A 3gwxB-3d5fA:
38.2
3gwxB-3d5fA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA


(Homo sapiens)
PF00104
(Hormone_recep)
6 PHE A 360
LEU A 339
VAL A 341
VAL A 348
LEU A 353
ILE A 364
None
L41  A 501 (-4.8A)
L41  A 501 ( 4.4A)
None
None
L41  A 501 ( 4.2A)
1.25A 3gwxB-3d5fA:
38.2
3gwxB-3d5fA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
6 LEU D 255
PHE D 282
GLN D 286
ILE D 326
MET D 329
LEU D 353
None
None
None
PLB  D 701 ( 4.5A)
None
None
0.72A 3gwxB-3dzuD:
34.4
3gwxB-3dzuD:
42.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE


(Lactobacillus
delbrueckii)
PF00155
(Aminotran_1_2)
5 LEU A 341
PHE A 362
VAL A 309
VAL A 385
LEU A 330
None
1.06A 3gwxB-3dzzA:
undetectable
3gwxB-3dzzA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
5 ARG A 127
ILE A 321
LEU A 165
VAL A 159
LEU A 115
None
1.10A 3gwxB-3e7oA:
undetectable
3gwxB-3e7oA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eay SENTRIN-SPECIFIC
PROTEASE 7


(Homo sapiens)
PF02902
(Peptidase_C48)
5 LEU A 701
ILE A 737
LEU A 694
VAL A 713
VAL A 696
None
1.13A 3gwxB-3eayA:
undetectable
3gwxB-3eayA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ein GLUTATHIONE
S-TRANSFERASE 1-1


(Drosophila
melanogaster)
PF00043
(GST_C)
PF02798
(GST_N)
6 ILE A 158
LEU A  27
VAL A  25
VAL A   2
LEU A  56
ILE A  69
None
1.24A 3gwxB-3einA:
undetectable
3gwxB-3einA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1)
no annotation 5 ARG A 743
GLN A 733
LEU A 798
LEU A 707
ILE A 778
None
1.04A 3gwxB-3f95A:
undetectable
3gwxB-3f95A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 LEU A 406
ILE A 485
LEU A 447
ILE A 427
MET A 283
None
1.12A 3gwxB-3i8bA:
undetectable
3gwxB-3i8bA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C)
PF06016
(Reovirus_L2)
5 LEU W 657
VAL W 620
VAL W 655
LEU W 644
ILE W 445
None
1.10A 3gwxB-3iylW:
undetectable
3gwxB-3iylW:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1


(Rattus
norvegicus)
PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec)
5 PHE A 161
GLN A 122
ILE A  14
MET A 224
VAL A 114
None
1.11A 3gwxB-3javA:
undetectable
3gwxB-3javA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt9 APRATAXIN

(Homo sapiens)
PF00498
(FHA)
5 LEU A  19
GLN A  44
VAL A  98
LEU A  81
ILE A  68
None
1.03A 3gwxB-3kt9A:
undetectable
3gwxB-3kt9A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhk PUTATIVE DNA BINDING
PROTEIN MJ0014


(Methanocaldococcus
jannaschii)
PF00239
(Resolvase)
5 ILE A  97
LEU A 117
VAL A 121
LEU A 137
ILE A 131
None
1.11A 3gwxB-3lhkA:
undetectable
3gwxB-3lhkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II


(Streptococcus
suis)
PF00155
(Aminotran_1_2)
5 GLN A 365
ILE A 357
LEU A 347
VAL A 345
LEU A 333
None
1.09A 3gwxB-3op7A:
undetectable
3gwxB-3op7A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow8 WD REPEAT-CONTAINING
PROTEIN 61


(Homo sapiens)
PF00400
(WD40)
5 PHE A   9
GLN A  11
VAL A 277
VAL A 256
ILE A   7
None
1.07A 3gwxB-3ow8A:
undetectable
3gwxB-3ow8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis)
no annotation 5 LEU A 282
ARG A 299
VAL A 246
VAL A 263
LEU A 261
None
1.03A 3gwxB-3p4gA:
undetectable
3gwxB-3p4gA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli)
PF00860
(Xan_ur_permease)
5 LEU A  91
GLN A 327
LEU A  80
VAL A  79
LEU A  83
None
1.14A 3gwxB-3qe7A:
undetectable
3gwxB-3qe7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk FUSION OF UREASE
BETA AND GAMMA
SUBUNITS


(Helicobacter
mustelae)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
5 ILE A 224
LEU A 129
VAL A 131
VAL A 184
LEU A 186
None
1.02A 3gwxB-3qgkA:
undetectable
3gwxB-3qgkA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 PHE A 358
ILE A 385
VAL A 344
VAL A 332
ILE A 351
None
1.14A 3gwxB-3qtpA:
undetectable
3gwxB-3qtpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rit DIPEPTIDE EPIMERASE

(Methylococcus
capsulatus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A 210
LEU A 159
VAL A 161
VAL A 187
LEU A 181
None
1.06A 3gwxB-3ritA:
undetectable
3gwxB-3ritA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN


(Thermotoga
maritima)
PF01256
(Carb_kinase)
PF03853
(YjeF_N)
5 LEU A 106
ILE A 152
VAL A 143
VAL A 112
ILE A 116
None
0.91A 3gwxB-3rreA:
undetectable
3gwxB-3rreA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum)
PF00491
(Arginase)
6 LEU A 187
ILE A 310
LEU A 355
VAL A 361
VAL A 405
ILE A 215
None
1.34A 3gwxB-3sl1A:
undetectable
3gwxB-3sl1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1u PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Azotobacter
vinelandii)
PF00160
(Pro_isomerase)
5 GLN A  97
ILE A  68
VAL A  31
LEU A  13
ILE A  83
None
1.14A 3gwxB-3t1uA:
undetectable
3gwxB-3t1uA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE


(Pantoea
ananatis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 305
VAL A  24
VAL A   9
LEU A  60
ILE A  71
None
1.14A 3gwxB-3t6cA:
undetectable
3gwxB-3t6cA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE


(Coxiella
burnetii)
PF01590
(GAF)
5 LEU A   7
ILE A  44
MET A  55
VAL A  27
ILE A 115
None
1.13A 3gwxB-3trcA:
undetectable
3gwxB-3trcA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txv PROBABLE TAGATOSE
6-PHOSPHATE KINASE


(Sinorhizobium
meliloti)
PF08013
(Tagatose_6_P_K)
5 LEU A 300
ILE A  50
LEU A 292
VAL A 415
MET A  66
None
1.03A 3gwxB-3txvA:
undetectable
3gwxB-3txvA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE


(Pyrococcus
horikoshii)
no annotation 5 LEU A 124
LEU A  81
VAL A  96
LEU A 129
ILE A 132
None
1.12A 3gwxB-3u4gA:
undetectable
3gwxB-3u4gA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uan HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
1


(Mus musculus)
PF00685
(Sulfotransfer_1)
6 GLN A  60
ILE A 137
VAL A 219
LEU A  74
ILE A  63
MET A 111
None
1.27A 3gwxB-3uanA:
undetectable
3gwxB-3uanA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyf GSP1P

(Saccharomyces
cerevisiae)
PF00071
(Ras)
5 GLN A 147
ILE A 151
LEU A  17
VAL A  16
ILE A  90
None
1.10A 3gwxB-3wyfA:
undetectable
3gwxB-3wyfA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zto NUCLEOSIDE
DIPHOSPHATE KINASE


(Aquifex
aeolicus)
PF00334
(NDK)
5 ILE A  89
VAL A  10
VAL A  73
LEU A  37
ILE A  34
None
0.96A 3gwxB-3ztoA:
undetectable
3gwxB-3ztoA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cob KYNURENINE
FORMAMIDASE


(Pseudomonas
aeruginosa)
PF04199
(Cyclase)
5 ARG A 138
VAL A 140
VAL A 108
LEU A 110
ILE A 127
None
1.08A 3gwxB-4cobA:
undetectable
3gwxB-4cobA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecd CHORISMATE SYNTHASE

(Bifidobacterium
longum)
PF01264
(Chorismate_synt)
5 GLN A 307
VAL A 225
VAL A 359
LEU A 363
ILE A 160
None
1.08A 3gwxB-4ecdA:
undetectable
3gwxB-4ecdA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flc ADENYLOSUCCINATE
LYASE


(Homo sapiens)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
5 ILE A 351
LEU A 186
VAL A 254
VAL A 189
LEU A 128
None
1.02A 3gwxB-4flcA:
undetectable
3gwxB-4flcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN


(Dyadobacter
fermentans)
PF00501
(AMP-binding)
5 LEU A 152
MET A   1
LEU A  79
VAL A 124
LEU A 147
None
1.12A 3gwxB-4gs5A:
undetectable
3gwxB-4gs5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN


(Synechococcus
elongatus)
PF00502
(Phycobilisome)
5 LEU B  30
ILE A  94
LEU B  19
VAL B   8
LEU A  38
None
1.00A 3gwxB-4h0mB:
undetectable
3gwxB-4h0mB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Dickeya
paradisiaca)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 305
VAL A  24
VAL A   9
LEU A  60
ILE A  71
None
1.14A 3gwxB-4ihcA:
undetectable
3gwxB-4ihcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io6 AVGLUR1 LIGAND
BINDING DOMAIN


(Adineta vaga)
PF00497
(SBP_bac_3)
5 LEU A  60
PHE A  20
ILE A 225
VAL A  58
LEU A  42
None
1.07A 3gwxB-4io6A:
undetectable
3gwxB-4io6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13


(Komagataella
pastoris;
Komagataella
phaffii)
PF00400
(WD40)
5 ARG A2034
ILE A1073
VAL A2057
LEU A2060
ILE A2044
EDO  A2409 ( 4.0A)
None
None
None
None
1.02A 3gwxB-4l9oA:
undetectable
3gwxB-4l9oA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN


(Mus musculus)
PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C)
5 PHE A 469
ILE A 348
LEU A 391
VAL A 398
LEU A 472
None
1.10A 3gwxB-4m4dA:
undetectable
3gwxB-4m4dA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A


(Streptomyces
sviceus)
PF00977
(His_biosynth)
5 LEU A 185
ILE A 129
VAL A 197
VAL A 189
LEU A 156
None
1.13A 3gwxB-4u28A:
undetectable
3gwxB-4u28A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN


(Arabidopsis
thaliana)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 LEU A 108
LEU A 245
VAL A 213
VAL A 243
LEU A 135
None
None
None
FAD  A 601 ( 4.2A)
FAD  A 601 (-4.7A)
0.94A 3gwxB-4ud8A:
undetectable
3gwxB-4ud8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uug AMINE TRANSAMINASE

(Aspergillus
fumigatus)
PF01063
(Aminotran_4)
5 LEU A 203
PHE A 174
GLN A 182
ILE A 117
MET A  85
None
None
None
None
FMT  A 405 (-4.7A)
1.01A 3gwxB-4uugA:
undetectable
3gwxB-4uugA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2


(Homo sapiens)
PF01463
(LRRCT)
PF13855
(LRR_8)
5 LEU A 291
GLN A 304
VAL A 350
VAL A 321
ILE A 328
None
1.13A 3gwxB-4v2dA:
undetectable
3gwxB-4v2dA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE


(Actinomyces
urogenitalis)
PF00977
(His_biosynth)
5 LEU A 179
ILE A 123
VAL A 191
VAL A 183
LEU A 150
None
1.01A 3gwxB-4x2rA:
undetectable
3gwxB-4x2rA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9s PHOSPHORIBOSYL
ISOMERASE A


(Streptomyces
sp. Mg1)
PF00977
(His_biosynth)
5 LEU A 183
ILE A 127
VAL A 195
VAL A 187
LEU A 154
None
1.12A 3gwxB-4x9sA:
undetectable
3gwxB-4x9sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL31
VIRION EGRESS
PROTEIN UL34


(Human
alphaherpesvirus
1)
PF02718
(Herpes_UL31)
PF04541
(Herpes_U34)
5 PHE B 243
ILE A 119
LEU B 116
VAL B  92
ILE B 231
None
None
None
None
NA  B 402 (-3.8A)
1.12A 3gwxB-4zxsB:
undetectable
3gwxB-4zxsB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2


(Eremothecium
gossypii)
PF10345
(Cohesin_load)
no annotation
5 LEU A 368
ILE A 277
LEU B  36
VAL A 391
LEU A 324
None
0.95A 3gwxB-5c6gA:
undetectable
3gwxB-5c6gA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii)
PF00118
(Cpn60_TCP1)
5 ARG A 506
GLN A 126
ILE A 446
VAL A 505
VAL A 413
None
0.97A 3gwxB-5cdiA:
undetectable
3gwxB-5cdiA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii)
PF16483
(Glyco_hydro_64)
5 LEU A 407
ILE A 131
LEU A 198
VAL A 235
LEU A 415
None
1.09A 3gwxB-5h9xA:
undetectable
3gwxB-5h9xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnp ABC TRANSPORTER

(Raoultella
ornithinolytica)
PF14524
(Wzt_C)
5 ILE A 380
VAL A 276
LEU A 281
ILE A 304
MET A 416
None
1.14A 3gwxB-5hnpA:
undetectable
3gwxB-5hnpA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2


(Homo sapiens)
PF00300
(His_Phos_1)
PF01591
(6PF2K)
5 LEU A 213
ARG A 137
LEU A  40
VAL A  42
VAL A 151
None
1.10A 3gwxB-5htkA:
undetectable
3gwxB-5htkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 LEU A 530
PHE A 271
GLN A 267
VAL A 182
ILE A 218
None
1.13A 3gwxB-5i2gA:
undetectable
3gwxB-5i2gA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER


(Shigella
flexneri)
PF02395
(Peptidase_S6)
5 LEU A 283
GLN A 360
VAL A 321
LEU A 328
ILE A 349
None
1.07A 3gwxB-5j44A:
undetectable
3gwxB-5j44A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2


(Zaire
ebolavirus)
PF01611
(Filo_glycop)
no annotation
5 LEU A  68
GLN B 551
VAL A  66
LEU A 184
ILE A  38
None
1.09A 3gwxB-5kenA:
undetectable
3gwxB-5kenA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kui CALCIUM UNIPORTER
PROTEIN,
MITOCHONDRIAL


(Homo sapiens)
no annotation 5 GLN A 114
ILE A 122
VAL A  75
VAL A 160
ILE A 127
None
1.05A 3gwxB-5kuiA:
undetectable
3gwxB-5kuiA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liq NICKING ENDONUCLEASE
N.BSPD6I


(Bacillus sp.
(in: Bacteria))
PF09491
(RE_AlwI)
5 ILE A 535
LEU A 545
VAL A 548
LEU A 559
ILE A 564
None
1.00A 3gwxB-5liqA:
undetectable
3gwxB-5liqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN


(Segniliparus
rugosus)
PF00501
(AMP-binding)
PF00550
(PP-binding)
5 LEU A  19
PHE A 294
ILE A 361
LEU A 423
VAL A 401
None
1.14A 3gwxB-5mswA:
undetectable
3gwxB-5mswA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN


(Chaetomium
thermophilum)
PF06427
(UDP-g_GGTase)
6 LEU A 431
GLN A 580
ILE A 511
VAL A 472
VAL A 483
LEU A 533
None
1.29A 3gwxB-5mzoA:
undetectable
3gwxB-5mzoA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger)
no annotation 5 ARG A 545
GLN A 542
VAL A 532
LEU A 298
ILE A 303
None
1.10A 3gwxB-5nitA:
undetectable
3gwxB-5nitA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE


(Meiothermus
ruber)
no annotation 5 LEU A 168
PHE A 120
LEU A 243
VAL A  77
VAL A 239
None
0.90A 3gwxB-5o6kA:
undetectable
3gwxB-5o6kA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tse LPS-ASSEMBLY
LIPOPROTEIN LPTE


(Acinetobacter
baumannii)
no annotation 5 GLN A 153
VAL A 102
VAL A  79
LEU A  77
ILE A 159
None
0.97A 3gwxB-5tseA:
undetectable
3gwxB-5tseA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8


(Homo sapiens)
PF00850
(Hist_deacetyl)
5 ILE A 284
LEU A 248
VAL A 247
VAL A 251
LEU A 173
None
0.91A 3gwxB-5vi6A:
undetectable
3gwxB-5vi6A:
21.72