SIMILAR PATTERNS OF AMINO ACIDS FOR 3GWX_A_EPAA1_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 19hc | PROTEIN (NINE-HAEMCYTOCHROME C) (Desulfovibriodesulfuricans) |
PF02085(Cytochrom_CIII) | 5 | CYH A 114THR A 118THR A 119ILE A 208HIS A 218 | HEM A 304 ( 1.8A)HEM A 304 (-3.2A)NoneHEM A 304 (-4.1A)HEM A 304 (-3.2A) | 1.19A | 3gwxA-19hcA:undetectable | 3gwxA-19hcA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxt | PROTEIN(STREPTOCOCCALSUPERANTIGEN) (Streptococcuspyogenes) |
PF01123(Stap_Strp_toxin)PF02876(Stap_Strp_tox_C) | 5 | THR A 219THR A 152THR A 114ILE A 144ILE A 128 | None | 1.32A | 3gwxA-1bxtA:0.0 | 3gwxA-1bxtA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cnz | PROTEIN(3-ISOPROPYLMALATEDEHYDROGENASE) (Salmonellaenterica) |
PF00180(Iso_dh) | 5 | THR A 39THR A 40HIS A 42ILE A 71LEU A 24 | None | 1.29A | 3gwxA-1cnzA:undetectable | 3gwxA-1cnzA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dys | ENDOGLUCANASE (Humicolainsolens) |
PF01341(Glyco_hydro_6) | 5 | THR A 196LEU A 259ILE A 213LEU A 187TYR A 246 | None | 1.31A | 3gwxA-1dysA:0.0 | 3gwxA-1dysA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fy1 | HEPARIN-BINDINGPROTEIN (Homo sapiens) |
PF00089(Trypsin) | 5 | THR A 147THR A 161THR A 149ILE A 1LEU A 179 | None | 1.12A | 3gwxA-1fy1A:undetectable | 3gwxA-1fy1A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o12 | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Thermotogamaritima) |
PF01979(Amidohydro_1) | 5 | THR A 81THR A 82THR A 58ILE A 143ILE A 170 | None | 1.19A | 3gwxA-1o12A:undetectable | 3gwxA-1o12A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y1u | SIGNAL TRANSDUCERAND ACTIVATOR OFTRANSCRIPTION 5A (Mus musculus) |
PF00017(SH2)PF01017(STAT_alpha)PF02864(STAT_bind) | 5 | THR A 158LEU A 151ILE A 320ILE A 286LEU A 229 | None | 1.25A | 3gwxA-1y1uA:0.0 | 3gwxA-1y1uA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ye8 | HYPOTHETICAL UPF0334KINASE-LIKE PROTEINAQ_1292 (Aquifexaeolicus) |
PF03266(NTPase_1) | 5 | THR A 52LEU A 24ILE A 3MET A 126LEU A 88 | None | 1.34A | 3gwxA-1ye8A:0.0 | 3gwxA-1ye8A:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c4k | PHOSPHORIBOSYLPYROPHOSPHATESYNTHETASE-ASSOCIATED PROTEIN 1 (Homo sapiens) |
PF13793(Pribosyltran_N)PF14572(Pribosyl_synth) | 5 | THR A 308THR A 325LEU A 22ILE A 66LEU A 289 | None | 1.06A | 3gwxA-2c4kA:0.0 | 3gwxA-2c4kA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c79 | GLYCOSIDE HYDROLASE,FAMILY11:CLOSTRIDIUMCELLULOSOME ENZYME,DOCKERIN TYPEI:POLYSACCHARIDE (Ruminiclostridiumthermocellum) |
PF01522(Polysacc_deac_1) | 5 | THR A 510THR A 659ILE A 525ILE A 526LEU A 502 | None | 1.11A | 3gwxA-2c79A:0.0 | 3gwxA-2c79A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ctz | O-ACETYL-L-HOMOSERINE SULFHYDRYLASE (Thermusthermophilus) |
PF01053(Cys_Met_Meta_PP) | 5 | THR A 103THR A 128ILE A 153ILE A 160LEU A 106 | None | 1.15A | 3gwxA-2ctzA:undetectable | 3gwxA-2ctzA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dch | PUTATIVE HOMINGENDONUCLEASE (Thermoproteus) |
PF14528(LAGLIDADG_3) | 5 | THR X 142LEU X 135ILE X 103ILE X 128LEU X 146 | None | 1.33A | 3gwxA-2dchX:undetectable | 3gwxA-2dchX:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ea9 | HYPOTHETICAL PROTEINYFJZ (Escherichiacoli) |
PF06154(CbeA_antitoxin) | 5 | CYH A 92THR A 91ILE A 63ILE A 66LEU A 55 | None | 1.17A | 3gwxA-2ea9A:undetectable | 3gwxA-2ea9A:16.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ep7 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Aquifexaeolicus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | CYH A 284LEU A 306ILE A 293ILE A 288LEU A 281 | None | 1.02A | 3gwxA-2ep7A:undetectable | 3gwxA-2ep7A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9i | ACETYL-COENZYME ACARBOXYLASE CARBOXYLTRANSFERASE SUBUNITBETA (Staphylococcusaureus) |
PF01039(Carboxyl_trans) | 5 | THR B 202THR B 205LEU B 161ILE B 70MET B 269 | None | 1.31A | 3gwxA-2f9iB:undetectable | 3gwxA-2f9iB:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hmc | DIHYDRODIPICOLINATESYNTHASE (Agrobacteriumfabrum) |
PF00701(DHDPS) | 5 | THR A 187THR A 180ILE A 5ILE A 75TYR A -3 | None | 1.14A | 3gwxA-2hmcA:undetectable | 3gwxA-2hmcA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j1q | ARGININE KINASE (Trypanosomacruzi) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 5 | CYH A 271THR A 269LEU A 82ILE A 65HIS A 90 | None | 1.16A | 3gwxA-2j1qA:undetectable | 3gwxA-2j1qA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ng1 | SIGNAL SEQUENCERECOGNITION PROTEINFFH (Thermusaquaticus) |
PF00448(SRP54)PF02881(SRP54_N) | 5 | THR A 48LEU A 31ILE A 13ILE A 74LEU A 5 | None | 1.25A | 3gwxA-2ng1A:undetectable | 3gwxA-2ng1A:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nuh | PERIPLASMIC DIVALENTCATION TOLERANCEPROTEIN (Xylellafastidiosa) |
PF03091(CutA1) | 5 | CYH A 33THR A 35LEU A 7ILE A 105ILE A 101 | None | 1.26A | 3gwxA-2nuhA:undetectable | 3gwxA-2nuhA:18.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p54 | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | CYH A 276THR A 279THR A 283HIS A 440LEU A 460TYR A 464 | 735 A 469 (-2.9A)735 A 469 (-3.6A)None735 A 469 (-4.0A)735 A 469 (-4.3A)735 A 469 (-4.6A) | 0.47A | 3gwxA-2p54A:37.9 | 3gwxA-2p54A:70.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p54 | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | CYH A 276THR A 283ILE A 354HIS A 440LEU A 460TYR A 464 | 735 A 469 (-2.9A)None735 A 469 (-3.7A)735 A 469 (-4.0A)735 A 469 (-4.3A)735 A 469 (-4.6A) | 0.77A | 3gwxA-2p54A:37.9 | 3gwxA-2p54A:70.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qik | UPF0131 PROTEIN YKQA (Bacillussubtilis) |
PF06094(GGACT)PF13772(AIG2_2) | 5 | THR A 165THR A 187THR A 186ILE A 252MET A 138 | None | 1.33A | 3gwxA-2qikA:undetectable | 3gwxA-2qikA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vd3 | ATPPHOSPHORIBOSYLTRANSFERASE (Methanothermobacterthermautotrophicus) |
PF01634(HisG)PF08029(HisG_C) | 5 | THR A 157THR A 144ILE A 104ILE A 110LEU A 171 | CL A1293 (-4.0A) CL A1293 ( 3.9A)NoneNoneNone | 1.32A | 3gwxA-2vd3A:undetectable | 3gwxA-2vd3A:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x6k | PHOSPHOTIDYLINOSITOL3 KINASE 59F (Drosophilamelanogaster) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka) | 5 | THR A 798LEU A 729ILE A 788MET A 849LEU A 841 | None | 1.21A | 3gwxA-2x6kA:undetectable | 3gwxA-2x6kA:18.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b0q | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | CYH A 285HIS A 323HIS A 449LEU A 469TYR A 473 | MC5 A 1 (-3.6A)MC5 A 1 (-3.8A)MC5 A 1 (-3.9A)MC5 A 1 (-4.1A)MC5 A 1 (-4.9A) | 0.67A | 3gwxA-3b0qA:36.2 | 3gwxA-3b0qA:61.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b0q | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | CYH A 285HIS A 323LEU A 330HIS A 449TYR A 473 | MC5 A 1 (-3.6A)MC5 A 1 (-3.8A)MC5 A 1 (-4.4A)MC5 A 1 (-3.9A)MC5 A 1 (-4.9A) | 0.87A | 3gwxA-3b0qA:36.2 | 3gwxA-3b0qA:61.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bex | TYPE IIIPANTOTHENATE KINASE (Thermotogamaritima) |
PF03309(Pan_kinase) | 5 | THR A 130THR A 131ILE A 202ILE A 199TYR A 140 | NonePAU A 248 (-4.5A)NoneNoneNone | 1.29A | 3gwxA-3bexA:undetectable | 3gwxA-3bexA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c4a | PROBABLE TRYPTOPHANHYDROXYLASE VIOD (Chromobacteriumviolaceum) |
no annotation | 5 | THR A 282THR A 283LEU A 58HIS A 53LEU A 363 | FAD A 401 (-3.7A)NoneNoneNoneNone | 1.27A | 3gwxA-3c4aA:undetectable | 3gwxA-3c4aA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9f | 5'-NUCLEOTIDASE (Candidaalbicans) |
PF00149(Metallophos) | 5 | THR A 32THR A 33THR A 35HIS A 217LEU A 110 | NoneNoneNone ZN A 601 (-3.5A)None | 1.22A | 3gwxA-3c9fA:undetectable | 3gwxA-3c9fA:20.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d5f | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR DELTA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | CYH A 285THR A 288LEU A 339ILE A 363ILE A 364 | L41 A 501 (-3.5A)L41 A 501 (-3.0A)L41 A 501 (-4.8A)L41 A 501 ( 4.4A)L41 A 501 ( 4.2A) | 1.20A | 3gwxA-3d5fA:39.9 | 3gwxA-3d5fA:99.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d5f | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR DELTA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | CYH A 285THR A 288THR A 289THR A 292HIS A 323LEU A 330ILE A 363ILE A 364HIS A 449MET A 453LEU A 469TYR A 473 | L41 A 501 (-3.5A)L41 A 501 (-3.0A)L41 A 501 (-3.5A)NoneL41 A 501 (-3.8A)L41 A 501 (-4.9A)L41 A 501 ( 4.4A)L41 A 501 ( 4.2A)L41 A 501 (-3.9A)L41 A 501 ( 3.7A)L41 A 501 (-3.8A)L41 A 501 (-4.8A) | 0.54A | 3gwxA-3d5fA:39.9 | 3gwxA-3d5fA:99.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epm | THIAMINEBIOSYNTHESIS PROTEINTHIC (Caulobactervibrioides) |
PF01964(ThiC_Rad_SAM)PF13667(ThiC-associated) | 5 | THR A 246LEU A 203ILE A 193ILE A 194MET A 411 | None | 1.04A | 3gwxA-3epmA:undetectable | 3gwxA-3epmA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7o | GROUP 3 ALLERGENSMIPP-S YV6023A04 (Sarcoptesscabiei) |
PF00089(Trypsin) | 5 | THR A 15LEU A 194ILE A 226ILE A 222LEU A 100 | None | 1.32A | 3gwxA-3h7oA:undetectable | 3gwxA-3h7oA:24.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibh | SACCHAROMYCESCEREVISIAE GTT2 (Saccharomycescerevisiae) |
PF00043(GST_C)PF13417(GST_N_3) | 5 | HIS A 133LEU A 125ILE A 197ILE A 193LEU A 53 | GSH A 234 (-3.4A)NoneNoneNoneGSH A 234 ( 4.6A) | 1.33A | 3gwxA-3ibhA:undetectable | 3gwxA-3ibhA:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kl2 | PUTATIVEISOCHORISMATASE (Streptomycesavermitilis) |
PF00857(Isochorismatase) | 5 | CYH A 181THR A 185THR A 188ILE A 97LEU A 173 | None | 0.65A | 3gwxA-3kl2A:undetectable | 3gwxA-3kl2A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lhl | PUTATIVE AGMATINASE (Clostridioidesdifficile) |
PF00491(Arginase) | 5 | THR A 229THR A 227HIS A 150ILE A 171TYR A 143 | NoneNonePO4 A 305 ( 4.2A)NonePO4 A 305 ( 4.5A) | 1.34A | 3gwxA-3lhlA:undetectable | 3gwxA-3lhlA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lkb | PROBABLEBRANCHED-CHAIN AMINOACID ABCTRANSPORTER, AMINOACID BINDING PROTEIN (Thermusthermophilus) |
PF13458(Peripla_BP_6) | 5 | THR A 124THR A 253ILE A 296ILE A 343TYR A 27 | None | 1.34A | 3gwxA-3lkbA:undetectable | 3gwxA-3lkbA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nnk | UREIDOGLYCINE-GLYOXYLATEAMINOTRANSFERASE (Klebsiellapneumoniae) |
PF00266(Aminotran_5) | 5 | CYH A 375THR A 378THR A 379ILE A 22LEU A 302 | NoneNoneNoneLLP A 200 ( 4.1A)None | 1.06A | 3gwxA-3nnkA:undetectable | 3gwxA-3nnkA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3olz | GLUTAMATE RECEPTOR,IONOTROPIC KAINATE 3 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 5 | CYH A 202THR A 230THR A 229ILE A 210LEU A 157 | None | 1.13A | 3gwxA-3olzA:undetectable | 3gwxA-3olzA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 324ILE A 387ILE A 389MET A 339LEU A 311 | None | 1.25A | 3gwxA-3oneA:undetectable | 3gwxA-3oneA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5r | TRANSCRIPTIONALREGULATOR TETRFAMILY (Syntrophusaciditrophicus) |
PF00440(TetR_N) | 5 | CYH A 98THR A 100ILE A 72ILE A 94MET A 71 | None | 1.16A | 3gwxA-3s5rA:undetectable | 3gwxA-3s5rA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tej | ENTEROBACTINSYNTHASE COMPONENT F (Escherichiacoli) |
PF00550(PP-binding)PF00975(Thioesterase) | 5 | THR A1166LEU A1135ILE A1286ILE A1283LEU A1262 | None | 1.17A | 3gwxA-3tejA:undetectable | 3gwxA-3tejA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqp | ENOLASE (Coxiellaburnetii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | THR A 350LEU A 338ILE A 362ILE A 363LEU A 322 | None | 1.22A | 3gwxA-3tqpA:undetectable | 3gwxA-3tqpA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txa | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcusagalactiae) |
PF00092(VWA) | 5 | THR A 695THR A 696ILE A 603LEU A 205TYR A 675 | None | 1.23A | 3gwxA-3txaA:undetectable | 3gwxA-3txaA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uwq | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Vibrio cholerae) |
PF00215(OMPdecase) | 5 | LEU A 119ILE A 132ILE A 130HIS A 139LEU A 146 | None | 1.30A | 3gwxA-3uwqA:undetectable | 3gwxA-3uwqA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vue | GRANULE-BOUND STARCHSYNTHASE 1,CHLOROPLASTIC/AMYLOPLASTIC (Oryza sativa) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 5 | HIS A 154ILE A 122ILE A 165MET A 120LEU A 214 | None | 1.20A | 3gwxA-3vueA:undetectable | 3gwxA-3vueA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vwa | CYTOPLASMIC EXPORTPROTEIN 1 (Saccharomycescerevisiae) |
no annotation | 5 | THR A 404THR A 407LEU A 365ILE A 381ILE A 385 | None | 1.21A | 3gwxA-3vwaA:undetectable | 3gwxA-3vwaA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zq4 | RIBONUCLEASE J 1 (Bacillussubtilis) |
PF00753(Lactamase_B)PF07521(RMMBL) | 5 | THR A 531THR A 533LEU A 512ILE A 551ILE A 552 | None | 1.20A | 3gwxA-3zq4A:undetectable | 3gwxA-3zq4A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aur | LEOA (Escherichiacoli) |
PF00350(Dynamin_N) | 5 | THR A 435THR A 436ILE A 549ILE A 428LEU A 542 | None | 1.26A | 3gwxA-4aurA:undetectable | 3gwxA-4aurA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1n | CODEHYDROGENASE/ACETYL-COA SYNTHASE,IRON-SULFUR PROTEIN (Carboxydothermushydrogenoformans) |
PF03599(CdhD) | 5 | THR B 233LEU B 238ILE B 224ILE B 223LEU B 34 | None | 1.30A | 3gwxA-4c1nB:undetectable | 3gwxA-4c1nB:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f8c | CYCLE INHIBITINGFACTOR (Yersiniapseudotuberculosis) |
PF16374(CIF) | 5 | THR A 201ILE A 230ILE A 235HIS A 226TYR A 175 | NoneEDO A 302 ( 4.5A)EDO A 302 (-4.6A)EDO A 302 (-3.9A)None | 1.01A | 3gwxA-4f8cA:undetectable | 3gwxA-4f8cA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fm9 | DNA TOPOISOMERASE2-ALPHA (Homo sapiens) |
PF00521(DNA_topoisoIV)PF01751(Toprim)PF16898(TOPRIM_C) | 5 | THR A 460THR A 540LEU A 553ILE A 513ILE A 510 | None | 1.23A | 3gwxA-4fm9A:undetectable | 3gwxA-4fm9A:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jz7 | CARBAMATE KINASE (Giardiaintestinalis) |
PF00696(AA_kinase) | 5 | THR A 286THR A 289ILE A 295ILE A 234LEU A 258 | None | 0.92A | 3gwxA-4jz7A:undetectable | 3gwxA-4jz7A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pfy | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN (Thermotogamaritima) |
PF00496(SBP_bac_5) | 5 | THR A 436ILE A 394ILE A 397LEU A 422TYR A 418 | None | 1.22A | 3gwxA-4pfyA:undetectable | 3gwxA-4pfyA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ptf | DNA POLYMERASEEPSILON CATALYTICSUBUNIT A (Saccharomycescerevisiae) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 5 | CYH A 497THR A 498LEU A 79MET A 420TYR A 485 | None | 1.33A | 3gwxA-4ptfA:undetectable | 3gwxA-4ptfA:11.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qxa | RAS-RELATED PROTEINRAB-9A (Mus musculus) |
PF00071(Ras) | 5 | THR A 126THR A 153THR A 159ILE A 121LEU A 23 | None | 1.02A | 3gwxA-4qxaA:undetectable | 3gwxA-4qxaA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf7 | ARGININE KINASE (Anthopleurajaponica) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 5 | HIS A 216LEU A 160ILE A 235ILE A 234LEU A 185 | None | 1.26A | 3gwxA-4rf7A:undetectable | 3gwxA-4rf7A:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s28 | PHOSPHOMETHYLPYRIMIDINE SYNTHASE,CHLOROPLASTIC (Arabidopsisthaliana) |
PF01964(ThiC_Rad_SAM) | 5 | THR A 255LEU A 212ILE A 202ILE A 203MET A 420 | None | 1.09A | 3gwxA-4s28A:undetectable | 3gwxA-4s28A:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wpz | CYTOCHROME P450 (Streptomycesavermitilis) |
PF00067(p450) | 5 | THR A 288THR A 287THR A 286ILE A 9LEU A 26 | None K A 501 (-3.5A)NoneNoneNone | 1.18A | 3gwxA-4wpzA:undetectable | 3gwxA-4wpzA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y07 | NEDD4-LIKE E3UBIQUITIN-PROTEINLIGASE WWP2 (Homo sapiens) |
PF00632(HECT) | 5 | THR A 799THR A 837ILE A 755ILE A 792LEU A 812 | None | 1.18A | 3gwxA-4y07A:undetectable | 3gwxA-4y07A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yte | H(2)-FORMINGMETHYLENETETRAHYDROMETHANOPTERINDEHYDROGENASE-RELATED PROTEIN MJ0715 (Methanocaldococcusjannaschii) |
no annotation | 5 | THR A 115THR A 89ILE A 111ILE A 84LEU A 123 | None | 1.35A | 3gwxA-4yteA:undetectable | 3gwxA-4yteA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zcf | RESTRICTIONENDONUCLEASEECOP15I,MODIFICATION SUBUNIT (Escherichiacoli) |
PF01555(N6_N4_Mtase) | 5 | THR A 446THR A 447THR A 450LEU A 422ILE A 197 | None | 0.90A | 3gwxA-4zcfA:undetectable | 3gwxA-4zcfA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zv6 | ALPHAREP-7 (syntheticconstruct) |
PF13646(HEAT_2) | 5 | THR A 250LEU A 224ILE A 237MET A 267TYR A 285 | None | 1.13A | 3gwxA-4zv6A:undetectable | 3gwxA-4zv6A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b7d | LYSR FAMILYTRANSCRIPTIONALREGULATOR (Vibriovulnificus) |
PF03466(LysR_substrate) | 5 | THR A 137THR A 136THR A 135HIS A 210LEU A 153 | None | 0.82A | 3gwxA-5b7dA:undetectable | 3gwxA-5b7dA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d3m | ENERGY-COUPLINGFACTOR TRANSPORTERTRANSMEMBRANEPROTEIN ECFT (Lactobacillusdelbrueckii) |
PF02361(CbiQ) | 5 | THR D 127THR D 129ILE D 32ILE D 119LEU D 25 | None | 1.29A | 3gwxA-5d3mD:undetectable | 3gwxA-5d3mD:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d9a | POLYMERASE ACIDICPROTEIN (Influenza Cvirus) |
PF00603(Flu_PA) | 5 | CYH A 570THR A 573THR A 574THR A 577LEU A 426 | None | 0.98A | 3gwxA-5d9aA:undetectable | 3gwxA-5d9aA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dcq | ARTIFICIAL REPEATPROTEINS (ALPHAREP3) (syntheticconstruct) |
PF03130(HEAT_PBS)PF13646(HEAT_2) | 5 | THR A 125LEU A 99ILE A 112MET A 142TYR A 160 | None | 1.13A | 3gwxA-5dcqA:undetectable | 3gwxA-5dcqA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ec3 | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (Homo sapiens) |
PF00903(Glyoxalase)PF13669(Glyoxalase_4) | 5 | THR A 337HIS A 266LEU A 269HIS A 183LEU A 367 | THR A 337 ( 0.8A)HIS A 266 (-1.0A)LEU A 269 ( 0.6A)HIS A 183 (-1.0A)LEU A 367 ( 0.6A) | 1.29A | 3gwxA-5ec3A:undetectable | 3gwxA-5ec3A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ere | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Desulfohalobiumretbaense) |
PF13458(Peripla_BP_6) | 5 | LEU A 588ILE A 370ILE A 496MET A 374LEU A 454 | None | 1.33A | 3gwxA-5ereA:undetectable | 3gwxA-5ereA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f0k | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 35 (Homo sapiens) |
PF03635(Vps35) | 5 | THR A 375THR A 376LEU A 350ILE A 404LEU A 424 | None | 1.18A | 3gwxA-5f0kA:undetectable | 3gwxA-5f0kA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fn4 | NICASTRIN (Homo sapiens) |
PF05450(Nicastrin) | 5 | THR A 561THR A 564THR A 563ILE A 338LEU A 627 | None | 0.97A | 3gwxA-5fn4A:undetectable | 3gwxA-5fn4A:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h64 | SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08771(FRB_dom)PF11865(DUF3385) | 5 | THR A1977LEU A2005ILE A2151ILE A2150LEU A2236 | None | 1.26A | 3gwxA-5h64A:undetectable | 3gwxA-5h64A:7.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdt | SISTER CHROMATIDCOHESION PROTEINPDS5 HOMOLOG B (Homo sapiens) |
no annotation | 5 | THR A 198LEU A 221ILE A 233ILE A 229LEU A 251 | None | 1.25A | 3gwxA-5hdtA:undetectable | 3gwxA-5hdtA:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hgc | SERPIN (Taeniopygiaguttata) |
PF00079(Serpin) | 5 | THR A 64HIS A 98LEU A 145ILE A 326LEU A 82 | NoneBDG A 505 ( 4.6A)NoneNoneNone | 1.09A | 3gwxA-5hgcA:undetectable | 3gwxA-5hgcA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j44 | SERINE PROTEASE SEPAAUTOTRANSPORTER (Shigellaflexneri) |
PF02395(Peptidase_S6) | 5 | THR A 619THR A 620HIS A 611HIS A 566MET A 564 | None | 1.23A | 3gwxA-5j44A:undetectable | 3gwxA-5j44A:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lkm | DNA REPAIR PROTEINRADA (Streptococcuspneumoniae) |
PF13481(AAA_25)PF13541(ChlI) | 5 | THR A 324THR A 323LEU A 361ILE A 374MET A 335 | None | 1.34A | 3gwxA-5lkmA:undetectable | 3gwxA-5lkmA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lkq | DNA REPAIR PROTEINRADA (Streptococcuspneumoniae) |
PF13541(ChlI) | 5 | THR A 324THR A 323LEU A 361ILE A 374MET A 335 | None | 1.30A | 3gwxA-5lkqA:undetectable | 3gwxA-5lkqA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nd1 | CAPSID PROTEIN (Rosellinianecatrixquadrivirus 1) |
no annotation | 5 | THR A 82THR A 84ILE A 760MET A 810LEU A 777 | None | 1.17A | 3gwxA-5nd1A:undetectable | 3gwxA-5nd1A:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnb | ISATIN HYDROLASE A (Labrenziaaggregata) |
no annotation | 5 | CYH A 108THR A 145THR A 189ILE A 125ILE A 124 | None | 1.35A | 3gwxA-5nnbA:undetectable | 3gwxA-5nnbA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5td3 | CATECHOL1,2-DIOXYGENASE (Burkholderiavietnamiensis) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | THR A 250THR A 115HIS A 235ILE A 147TYR A 175 | NoneNone ZN A 401 (-3.2A)None ZN A 401 (-4.2A) | 1.20A | 3gwxA-5td3A:undetectable | 3gwxA-5td3A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5td3 | CATECHOL1,2-DIOXYGENASE (Burkholderiavietnamiensis) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | THR A 250THR A 115HIS A 235ILE A 295TYR A 175 | NoneNone ZN A 401 (-3.2A)None ZN A 401 (-4.2A) | 1.32A | 3gwxA-5td3A:undetectable | 3gwxA-5td3A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5txr | 5-AMINOLEVULINATESYNTHASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
no annotation | 5 | CYH B 119THR B 463THR B 465ILE B 438LEU B 476 | None | 1.33A | 3gwxA-5txrB:undetectable | 3gwxA-5txrB:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5umh | CATECHOL1,2-DIOXYGENASE (Burkholderiamultivorans) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | THR A 239THR A 104HIS A 224ILE A 136TYR A 164 | NoneNone ZN A 401 ( 3.3A)None ZN A 401 ( 4.2A) | 1.24A | 3gwxA-5umhA:undetectable | 3gwxA-5umhA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5umh | CATECHOL1,2-DIOXYGENASE (Burkholderiamultivorans) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | THR A 239THR A 104HIS A 224ILE A 284TYR A 164 | NoneNone ZN A 401 ( 3.3A)None ZN A 401 ( 4.2A) | 1.28A | 3gwxA-5umhA:undetectable | 3gwxA-5umhA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uuo | GLUTATHIONES-TRANSFERASE-LIKEPROTEIN (Novosphingobiumaromaticivorans) |
no annotation | 5 | THR B 63LEU B 262ILE B 289LEU B 214TYR B 209 | None | 1.33A | 3gwxA-5uuoB:undetectable | 3gwxA-5uuoB:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x2q | TASTE RECEPTOR, TYPE1, MEMBER 2A (Oryzias latipes) |
PF01094(ANF_receptor) | 5 | THR A 141HIS A 100ILE A 42ILE A 64LEU A 39 | GLY A 951 (-4.4A)NoneNoneNoneNone | 1.30A | 3gwxA-5x2qA:undetectable | 3gwxA-5x2qA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xd7 | 3,6-ANHYDRO-ALPHA-L-GALACTONATECYCLOISOMERASE (Vibrio sp. EJY3) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | THR A 38THR A 37ILE A 84MET A 88LEU A 65 | None | 1.15A | 3gwxA-5xd7A:undetectable | 3gwxA-5xd7A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xii | PROLYL-TRNASYNTHETASE (PRORS) (Toxoplasmagondii) |
no annotation | 5 | THR A 593THR A 592LEU A 480ILE A 356ILE A 350 | NoneANP A1001 (-2.7A)NoneNoneNone | 1.22A | 3gwxA-5xiiA:undetectable | 3gwxA-5xiiA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xio | PROLINE-TRNASYNTHETASE CLASS IIAARS (YBAK RNABINDING DOMAIN PLUSTRNA SYNTHETASE) (Cryptosporidiumparvum) |
no annotation | 5 | THR A 369THR A 374HIS A 367ILE A 442ILE A 439 | NoneANP A 803 (-4.3A)NoneNoneNone | 1.30A | 3gwxA-5xioA:undetectable | 3gwxA-5xioA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyn | PLATINUM SENSITIVITYPROTEIN 3 (Saccharomycescerevisiae) |
no annotation | 5 | LEU A 60ILE A 222ILE A 223MET A 216LEU A 138 | None | 1.26A | 3gwxA-5xynA:undetectable | 3gwxA-5xynA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyn | PLATINUM SENSITIVITYPROTEIN 3 (Saccharomycescerevisiae) |
no annotation | 5 | LEU A 60ILE A 222MET A 216LEU A 138TYR A 215 | None | 1.18A | 3gwxA-5xynA:undetectable | 3gwxA-5xynA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y0m | - (-) |
no annotation | 5 | THR A 315LEU A 213ILE A 104ILE A 75LEU A 283 | None | 1.33A | 3gwxA-5y0mA:undetectable | 3gwxA-5y0mA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yz0 | SERINE/THREONINE-PROTEIN KINASE ATR (Homo sapiens) |
no annotation | 5 | THR A2364LEU A2338ILE A2470MET A2543LEU A2349 | None | 1.31A | 3gwxA-5yz0A:undetectable | 3gwxA-5yz0A:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 280ILE A 341ILE A 343MET A 295LEU A 267 | None | 1.31A | 3gwxA-6aphA:undetectable | 3gwxA-6aphA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eks | SIALIDASE (Vibrio cholerae) |
no annotation | 5 | THR A 481THR A 480THR A 479LEU A 447ILE A 422 | None | 1.35A | 3gwxA-6eksA:undetectable | 3gwxA-6eksA:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | PROTEIN CFT1 (Saccharomycescerevisiae) |
no annotation | 5 | THR A 826LEU A1286ILE A 60HIS A1221TYR A 4 | None | 1.32A | 3gwxA-6eojA:undetectable | 3gwxA-6eojA:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eyy | ACRIIA6 (Streptococcusphage 73) |
no annotation | 5 | LEU A 12ILE A 3ILE A 48MET A 1LEU A 69 | None | 1.25A | 3gwxA-6eyyA:undetectable | 3gwxA-6eyyA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ez8 | HUNTINGTIN (Homo sapiens) |
no annotation | 5 | THR A2252LEU A2303HIS A2183LEU A2201TYR A2197 | None | 1.33A | 3gwxA-6ez8A:undetectable | 3gwxA-6ez8A:10.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH DEHYDROGENASE[UBIQUINONE]FLAVOPROTEIN 1,MITOCHONDRIALNADH DEHYDROGENASE[UBIQUINONE]IRON-SULFUR PROTEIN4, MITOCHONDRIAL (Mus musculus) |
no annotation | 5 | CYH F 405THR F 403ILE F 185LEU F 205TYR Q 118 | SF4 F 502 (-2.2A)SF4 F 502 ( 4.0A)SF4 F 502 ( 4.2A)NoneNone | 1.11A | 3gwxA-6g2jF:undetectable | 3gwxA-6g2jF:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN5 (Mus musculus) |
no annotation | 5 | THR L 284THR L 285THR L 288LEU L 310ILE L 395 | None | 1.16A | 3gwxA-6g2jL:undetectable | 3gwxA-6g2jL:14.02 |